A. LeBlanc

发表

Luman contributes to brefeldin A-induced prion protein gene expression by interacting with the ERSE26 element

M. Déry, A. LeBlanc, 2017, Scientific Reports.

Identification of a Novel Endoplasmic Reticulum Stress Response Element Regulated by XBP1*

Derek A. Ruths, M. Déry, A. LeBlanc, 2013, The Journal of Biological Chemistry.

Amyloid β Peptide of Alzheimer’s Disease Downregulates Bcl-2 and Upregulates Bax Expression in Human Neurons

A. LeBlanc, E. Paradis, H. Douillard, 1996, The Journal of Neuroscience.

Selective cytotoxicity of intracellular amyloid β peptide1–42 through p53 and Bax in cultured primary human neurons

A. LeBlanc, C. Goodyer, Yan Zhang, 2002, The Journal of cell biology.

Synthesis and evaluation of novel dipeptidyl benzoyloxymethyl ketones as caspase inhibitors.

A. LeBlanc, H. Nedev, Guy Klaiman, 2005, Biochemical and biophysical research communications.

Fatal familial insomnia and familial Creutzfeldt-Jakob disease: disease phenotype determined by a DNA polymorphism.

P Brown, M. Tabaton, P. Cortelli, 1992, Science.

Monitoring Caspases in Neuronal Cell Death

A. LeBlanc, O. Tounekti, Younes Bounhar, 2002 .

Effect of tumor necrosis factor‐α converting enzyme (TACE) and metalloprotease inhibitor on amyloid precursor protein metabolism in human neurons

A. LeBlanc, M. Blacker, C. Goodyer, 2002, Journal of neurochemistry.

Defective Retrotranslocation Causes Loss of Anti-Bax Function in Human Familial Prion Protein Mutants

A. LeBlanc, J. Jodoin, C. Goodyer, 2007, The Journal of Neuroscience.

The Consortium for the early identification of Alzheimer's disease–Quebec (CIMA-Q)

S. Hébert, Pierre Bellec, S. Duchesne, 2019, Alzheimer's & dementia.

Involvement of Caspases in Proteolytic Cleavage of Alzheimer’s Amyloid-β Precursor Protein and Amyloidogenic Aβ Peptide Formation

David Smith, G. Robertson, Daigen Xu, 1999, Cell.

Therapeutic potential of Nlrp1 inflammasome, Caspase-1, or Caspase-6 against Alzheimer disease cognitive impairment

A. LeBlanc, J. Flores, Anastasia Noël, 2021, Cell Death & Differentiation.

Microinjections to Study the Specific Role of Proapoptotic Proteins in Neurons

A. LeBlanc, Yan Zhang, 2002 .

17-β-Estradiol Induces an Inhibitor of Active Caspases

A. LeBlanc, C. Goodyer, Yan Zhang, 2001, The Journal of Neuroscience.

Amyloid Precursor Protein Metabolism in Primary Cell Cultures of Neurons, Astrocytes, and Microglia

R. Xue, P. Gambetti, A. LeBlanc, 1996, Journal of neurochemistry.

Role of Endoplasmic Reticulum, Endosomal–Lysosomal Compartments, and Microtubules in Amyloid Precursor Protein Metabolism of Human Neurons

A. LeBlanc, C. Goodyer, 1999, Journal of neurochemistry.

Prion Protein Protects Human Neurons against Bax-mediated Apoptosis*

A. LeBlanc, C. Goodyer, Yan Zhang, 2001, The Journal of Biological Chemistry.

Human Prion Protein Gene Mutation at Codon 183 Associated with an Atypical Form of Prion Disease

M. Passos-Bueno, M. Zatz, R. Nitrini, 1998 .

p75 Neurotrophin Receptor Protects Primary Cultures of Human Neurons against Extracellular Amyloid β Peptide Cytotoxicity

X. Roucou, H. Federoff, A. LeBlanc, 2003, The Journal of Neuroscience.

Detection of actin cleavage in Alzheimer's disease.

A. LeBlanc, 1998, The American journal of pathology.

Protein Kinase C Activation Increases Release of Secreted Amyloid Precursor Protein without Decreasing Aβ Production in Human Primary Neuron Cultures.

A. LeBlanc, M. Koutroumanis, C. Goodyer, 1998, The Journal of Neuroscience.

Regulation of apolipoprotein E gene expression after injury of the rat sciatic nerve

A. LeBlanc, J. Poduslo, 1990, Journal of neuroscience research.

Cellular prion protein neuroprotective function: implications in prion diseases

X. Roucou, A. LeBlanc, 2004, Journal of Molecular Medicine.

Neuroprotective functions of prion protein

X. Roucou, A. LeBlanc, Malcolm J Gains, 2004, Journal of neuroscience research.

Hereditary Inclusion Body Myopathy-Linked p97/VCP Mutations in the NH2 Domain and the D1 Ring Modulate p97/VCP ATPase Activity and D2 Ring Conformation

M. Latterich, S. Michnick, I. Rouiller, 2009, Molecular and Cellular Biology.

Prion disease resembling frontotemporal dementia and parkinsonism linked to chromosome 17.

M. Passos-Bueno, M. Zatz, R. Nitrini, 2001, Arquivos de neuro-psiquiatria.

In vitro translation of mRNA from the developing sciatic nerve.

A. LeBlanc, C. Mezei, 1985, Brain research.

Processing of Amyloid Precursor Protein in Human Primary Neuron and Astrocyte Cultures

A. LeBlanc, C. Goodyer, C. Bélair, 1997, Journal of neurochemistry.

Caspase-1 inhibition improves cognition without significantly altering amyloid and inflammation in aged Alzheimer disease mice

A. LeBlanc, J. Flores, Marie-Lyne Fillion, 2022, Cell Death & Disease.

Mammalian and avian PO protein of the peripheral nervous system myelin are different.

A. LeBlanc, C. Mezei, 1987, Comparative biochemistry and physiology. B, Comparative biochemistry.

Regulation of 2',3'-cyclic nucleotide phosphodiesterase gene expression in experimental peripheral neuropathies.

A. LeBlanc, J. Poduslo, J. Pringle, 1992, Brain research. Molecular brain research.

Stem Cell-Derived Neurons as Cellular Models of Sporadic Alzheimer's Disease.

S. Hébert, S. Duchesne, S. Belleville, 2019, Journal of Alzheimer's disease : JAD.

A role for extracellular matrix degradation and matrix metalloproteinases in senile dementia?

A. LeBlanc, A. Bignami, G. Perides, 1994, Acta Neuropathologica.

Prion protein protects against ethanol-induced Bax-mediated cell death in vivo

K. Roth, A. LeBlanc, Malcolm J Gains, 2006, Neuroreport.

Fatal familial insomnia

E. Sforza, P. Cortelli, M. Contin, 1992, Neurology.

Molecular p 75 Neurotrophin Receptor Protects Primary Cultures of Human Neurons against Extracellular Amyloid Peptide Cytotoxicity

X. Roucou, H. Federoff, A. LeBlanc, 2003 .

Proteasomal degradation of caspase‐6 in 17β‐estradiol‐treated neurons

A. LeBlanc, C. Goodyer, Yan Zhang, 2004, Journal of neurochemistry.

AMYLOID PROTEIN PRECURSOR (APP) EXPRESSION AND METABOLISM IN HUMAN NERVOUS SYSTEM PRIMARY CULTURES FROM NORMAL AND ALZHEIMER DISEASE (AD) INDIVIDUALS

R. Xue, P. Gambetti, A. LeBlanc, 1993 .

The apolipoprotein A-I gene is actively expressed in the rapidly myelinating avian peripheral nerve

A. LeBlanc, D. Spencer, D. Williams, 1989, The Journal of cell biology.

Familial prion protein mutants inhibit Hrd1-mediated retrotranslocation of misfolded proteins by depleting misfolded protein sensor BiP.

M. Déry, A. LeBlanc, S. L. Peters, 2016, Human molecular genetics.

Cytosolic prion protein is the predominant anti-Bax prion protein form: exclusion of transmembrane and secreted prion protein forms in the anti-Bax function.

A. LeBlanc, J. Jodoin, C. Goodyer, 2008, Biochimica et biophysica acta.

Increased Caspase-6 activity in the human anterior olfactory nuclei of the olfactory bulb is associated with cognitive impairment

D. Bennett, S. Albrecht, A. LeBlanc, 2016, Acta Neuropathologica Communications.

Familial amyloid precursor protein mutants cause caspase-6-dependent but amyloid β-peptide-independent neuronal degeneration in primary human neuron cultures.

A. LeBlanc, C. Goodyer, S. Sivananthan, 2010, Cell Death and Disease.

The role of apoptotic pathways in Alzheimer's disease neurodegeneration and cell death.

A. LeBlanc, Andrea C LeBlanc, 2005, Current Alzheimer research.

Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model

C. Lecrux, A. LeBlanc, B. Foveau, 2018, Nature Communications.

Lithocholic bile acid selectively kills neuroblastoma cells, while sparing normal neuronal cells

V. Titorenko, A. LeBlanc, A. Beach, 2011, Oncotarget.

Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation

B. Hyman, B. Ghetti, B. Koller, 2015, Cell Death and Differentiation.

Cellular prion protein inhibits proapoptotic Bax conformational change in human neurons and in breast carcinoma MCF-7 cells

X. Roucou, Yan Zhang, A. LeBlanc, 2005, Cell Death and Differentiation.

MicroRNA profiling reveals new aspects of HIV neurodegeneration: caspase‐6 regulates astrocyte survival

M. Hollenberg, C. Power, A. LeBlanc, 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Loss of Anti-Bax Function in Gerstmann-Sträussler-Scheinker Syndrome-Associated Prion Protein Mutants

A. LeBlanc, J. Jodoin, C. Goodyer, 2009, PloS one.

Apoptosis and Alzheimer’s Disease

A. LeBlanc, 1997 .

Natural cellular inhibitors of caspases

A. LeBlanc, 2003, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self‐activation

W. Mi, Lan-fen Li, X. Su, 2010, EMBO reports.

Caspase-6 Activation in Familial Alzheimer Disease Brains Carrying Amyloid Precursor Protein or Presenilin I or Presenilin II Mutations

B. Winblad, B. Ghetti, N. Bogdanovic, 2009, Journal of neuropathology and experimental neurology.

Testosterone‐mediated neuroprotection through the androgen receptor in human primary neurons

A. LeBlanc, C. Goodyer, M. Trifiro, 2001, Journal of neurochemistry.

Increased production of 4 kDa amyloid beta peptide in serum deprived human primary neuron cultures: possible involvement of apoptosis

A. LeBlanc, A. C. LeBlanc, 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Caspase-6 Role in Apoptosis of Human Neurons, Amyloidogenesis, and Alzheimer’s Disease*

C. Bergeron, A. LeBlanc, C. Goodyer, 1999, The Journal of Biological Chemistry.

Selective and Protracted Apoptosis in Human Primary Neurons Microinjected with Active Caspase-3, -6, -7, and -8

Yan Zhang, A. LeBlanc, C. Goodyer, 2000, The Journal of Neuroscience.

Identification of Caspase-6-Mediated Processing of the Valosin Containing Protein (p97) in Alzheimer's Disease: A Novel Link to Dysfunction in Ubiquitin Proteasome System-Mediated Protein Degradation

D. Bennett, M. Latterich, A. LeBlanc, 2010, The Journal of Neuroscience.

Fatal familial insomnia, a prion disease with a mutation at codon 178 of the prion protein gene.

H. Y. Chen, J. Ott, P. Cortelli, 1992, The New England journal of medicine.

Telomerase and neuronal marker status of differentiated NT2 and SK‐N‐SH human neuronal cells and primary human neurons

M. Cerone, A. LeBlanc, C. Autexier, 2007, Journal of neuroscience research.

Identification of Allosteric Inhibitors against Active Caspase-6

G. Lukács, B. Nagar, A. LeBlanc, 2019, Scientific Reports.

Rare human Caspase-6-R65W and Caspase-6-G66R variants identify a novel regulatory region of Caspase-6 activity

J. Hardy, S. Savinov, A. LeBlanc, 2018, Scientific Reports.

Inflammation-Induced Tumorigenesis in Mouse Colon Is Caspase-6 Independent

N. Beauchemin, S. Albrecht, A. LeBlanc, 2014, PloS one.

Expression and Activation of Caspase-6 in Human Fetal and Adult Tissues

S. Albrecht, A. LeBlanc, B. Foveau, 2013, PloS one.

Caspase‐6 as a novel early target in the treatment of Alzheimer's disease

A. LeBlanc, 2013, The European journal of neuroscience.

Alternatively Spliced Caspase-6B Isoform Inhibits the Activation of Caspase-6A*

X. Su, A. LeBlanc, Xiaojun Wang, 2010, The Journal of Biological Chemistry.

Therapeutic potential of Nlrp1 inflammasome, Caspase-1, or Caspase-6 against Alzheimer disease cognitive impairment

A. LeBlanc, J. Flores, Anastasia Noël, 2021, Cell Death & Differentiation.

Rare CASP6N73T variant associated with hippocampal volume exhibits decreased proteolytic activity, synaptic transmission defect, and neurodegeneration

A. Saykin, K. Nho, A. LeBlanc, 2021, Scientific Reports.

Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice

E. Hamel, C. Lecrux, A. LeBlanc, 2017, Molecular Neurodegeneration.

Caspase-mediated cleavage of actin and tubulin is a common feature and sensitive marker of axonal degeneration in neural development and injury

C. Deppmann, J. Mandell, A. LeBlanc, 2014, Acta neuropathologica communications.

Caspase-6 activity in the CA1 region of the hippocampus induces age-dependent memory impairment

E. Hamel, D. Bennett, A. LeBlanc, 2014, Cell Death and Differentiation.

Caspase-6 activity predicts lower episodic memory ability in aged individuals

D. Bennett, S. Albrecht, A. LeBlanc, 2013, Neurobiology of Aging.

Self-activation of Caspase-6 in vitro and in vivo: Caspase-6 activation does not induce cell death in HEK293T cells.

A. LeBlanc, Guy Klaiman, N. Champagne, 2009, Biochimica et biophysica acta.

Targets of Caspase-6 Activity in Human Neurons and Alzheimer Disease*S

A. LeBlanc, Guy Klaiman, Jennifer Hammond, 2008, Molecular & Cellular Proteomics.

Activation of caspase-6 in aging and mild cognitive impairment.

D. Bennett, E. Mufson, S. Albrecht, 2007, The American journal of pathology.

Active caspase-6 and caspase-6-cleaved tau in neuropil threads, neuritic plaques, and neurofibrillary tangles of Alzheimer's disease.

S. Albrecht, C. Bergeron, A. LeBlanc, 2004, The American journal of pathology.

Caspase-1 activation of caspase-6 in human apoptotic neurons

H. Guo, C. Bergeron, Yan Zhang, 2006, Cell Death and Differentiation.

Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging

O. Beauchet, A. LeBlanc, B. Foveau, 2020, Nature Communications.

Methylene blue inhibits Caspase-6 activity, and reverses Caspase-6-induced cognitive impairment and neuroinflammation in aged mice

P. J. Sjöström, O. Beauchet, A. LeBlanc, 2019, Acta Neuropathologica Communications.

Differential susceptibility of striatal, hippocampal and cortical neurons to Caspase-6

P. J. Sjöström, A. LeBlanc, B. Foveau, 2017, Alzheimer's & Dementia.

Cell-specific regulation of TRBP1 promoter by NF-Y transcription factor in lymphocytes and astrocytes.

J. Hiscott, A. Gatignol, A. LeBlanc, 2006, Journal of molecular biology.

Methylene Blue Inhibits Caspases by Oxidation of the Catalytic Cysteine

A. LeBlanc, B. Foveau, V. Kaushal, 2015, Scientific Reports.

Caspase-6-cleaved Tau fails to induce Tau hyperphosphorylation and aggregation, neurodegeneration, glial inflammation, and cognitive deficits

A. LeBlanc, B. Foveau, Anastasia Noël, 2021, Cell Death & Disease.

The role of β-amyloid peptide in alzheimer's disease

A. LeBlanc, 1994, Metabolic Brain Disease.

Differential APP gene expression in rat cerebral cortex, meninges, and primary astroglial, microglial and neuronal cultures

H. Y. Chen, L. Autilio‐Gambetti, P. Gambetti, 1991, FEBS letters.

Role of amyloid precursor protein (APP): Study with antisense transfection of human neuroblastoma cells

H. Y. Chen, D. Kovacs, M. Tykocinski, 1992, Journal of neuroscience research.

Proteomic identification of synaptic caspase substrates

J. Mandell, A. LeBlanc, James W Mandell, 2018, Synapse.

Regulated by XBP 1 Reticulum Stress Response Element Identification of a Novel Endoplasmic Gene Regulation

Derek A. Ruths, M. Déry, A. LeBlanc, 2013 .

Endoplasmic reticulum stress induces PRNP prion protein gene expression in breast cancer

J. Ursini-Siegel, M. Basik, M. Déry, 2013, Breast Cancer Research.

Canadian Association of Neurosciences Review: Prion Protein and Prion Diseases: The Good and the Bad

A. LeBlanc, Malcolm J Gains, 2007, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

Unraveling the Controversy of Human Prion Protein Diseases

A. LeBlanc, 1998 .

Familial spongiform encephalopathy associated with a novel prion protein gene mutation

M. Passos-Bueno, M. Zatz, R. Nitrini, 1997, Annals of neurology.

Diffusion-weighted MRI in two cases of familial Creutzfeldt–Jakob disease

R. Nitrini, A. LeBlanc, S. Marie, 2001, Journal of the Neurological Sciences.

Cytosolic Prion Protein Is Not Toxic and Protects against Bax-mediated Cell Death in Human Primary Neurons*

X. Roucou, A. LeBlanc, C. Goodyer, 2003, Journal of Biological Chemistry.

Estrogen and Androgen Protection of Human Neurons against Intracellular Amyloid β1-42 Toxicity through Heat Shock Protein 70

A. LeBlanc, C. Goodyer, Yan Zhang, 2004, The Journal of Neuroscience.

Introspective analysis of amyloid as the cause of Alzheimer’s disease: alternative model proposed

A. LeBlanc, 2008 .

Cerebrospinal fluid tau cleaved by caspase-6 reflects brain levels and cognition in aging and Alzheimer disease.

D. Bennett, S. Albrecht, A. LeBlanc, 2013, Journal of neuropathology and experimental neurology.

Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation.

G. Robertson, M. Rigby, R. Zamboni, 1999, Cell.

Prion protein prevents Bax-mediated cell death in the absence of other Bcl-2 family members in Saccharomyces cerevisiae.

X. Roucou, A. LeBlanc, K. Mann, 2006, FEMS yeast research.

Gene expression in the presence or absence of myelin assembly.

A. LeBlanc, J. Poduslo, C. Mezei, 1987, Brain research.

Endoplasmic reticulum stress induces PRNP prion protein gene expression in breast cancer

J. Ursini-Siegel, M. Basik, M. Déry, 2013, Breast Cancer Research.

Differential susceptibility of striatal, hippocampal and cortical neurons to Caspase-6

P. J. Sjöström, A. LeBlanc, B. Foveau, 2018, Cell Death & Differentiation.

Helix 3 is necessary and sufficient for prion protein’s anti‐Bax function

A. LeBlanc, J. Jodoin, Stéphanie Laroche-Pierre, 2009, Journal of neurochemistry.

Phosphorylation of Prion Protein at Serine 43 Induces Prion Protein Conformational Change

Stephanie A Booth, S. Booth, Catherine Robertson, 2009, The Journal of Neuroscience.

Publisher Correction: Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging

O. Beauchet, A. LeBlanc, B. Foveau, 2021, Nature Communications.

Increased Caspase-6 activity in the human anterior olfactory nuclei of the olfactory bulb is associated with cognitive impairment

D. Bennett, S. Albrecht, A. LeBlanc, 2016, Acta neuropathologica communications.

P0 gene expression in Schwann cells is modulated by an increase of cAMP which is dependent on the presence of axons.

A. Windebank, A. LeBlanc, J. Poduslo, 1992, Brain research. Molecular brain research.

Cyclin-dependent Kinase 5 Phosphorylation of Familial Prion Protein Mutants Exacerbates Conversion into Amyloid Structure*

A. LeBlanc, R. Rouget, Gyanesh Sharma, 2015, The Journal of Biological Chemistry.

Axonal modulation of myelin gene expression in the peripheral nerve

A. LeBlanc, J. Poduslo, 1990, Journal of neuroscience research.

A 42 K protein of chick sciatic nerve is immunologically related to PO protein of peripheral nerve myelin

A. LeBlanc, C. Mezei, D. Nunn, 1987, Neurochemical Research.

Increased blood manganese in cirrhotic patients: Relationship to pallidal magnetic resonance signal hyperintensity and neurological symptoms

R. Butterworth, L. Spahr, A. LeBlanc, 1996, Hepatology.

Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model

C. Lecrux, A. LeBlanc, B. Foveau, 2018, Nature Communications.

Apoptosis techniques and protocols

A. LeBlanc, 2002 .

Caspases, amyloid metabolism and Alzheimer's disease

C. Bergeron, A. LeBlanc, Yan Zhang, 2000, Neurobiology of Aging.