N. Ruggli

N. Ruggli, A. Summerfield, L. Hüsser, 2012, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

High IFN-alpha responses associated with depletion of lymphocytes and natural IFN-producing cells during classical swine fever.

K. McCullough, N. Ruggli, A. Summerfield, 2006, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Self-Replicating RNA Vaccine Delivery to Dendritic Cells.

K. McCullough, C. Pichon, T. Démoulins, 2017, Methods in molecular biology.

The specific features of the developing T cell compartment of the neonatal lung are a determinant of respiratory syncytial virus immunopathogenesis

T. Démoulins, N. Ruggli, A. Taddeo, 2020, bioRxiv.

Susceptibility of Well-Diﬀ erentiated Airway Epithelial Cell Cultures from Domestic and Wild Animals to Severe Acute Respiratory Syndrome Coronavirus 2

N. Ruggli, V. Thiel, R. Dijkman, 2022 .

Fibrocytes are potent stimulators of anti‐virus cytotoxic T cells

K. McCullough, N. Ruggli, C. Balmelli, 2005, Journal of leukocyte biology.

Classical Swine Fever Virus Can Remain Virulent after Specific Elimination of the Interferon Regulatory Factor 3-Degrading Function of Npro

J. Tratschin, N. Ruggli, Y. Sakoda, 2008, Journal of Virology.

Classical swine fever virus can remain virulent after specific 1 elimination of the interferon regulatory factor 3 degrading 2 function of N pro . 3 4

J. Tratschin, N. Ruggli, Y. Sakoda, 2008 .

Classical swine fever virus replicon particles lacking the Erns gene: a potential marker vaccine for intradermal application.

J. Tratschin, N. Ruggli, C. Frey, 2006, Veterinary research.

Removal of the Erns RNase Activity and of the 3′ Untranslated Region Polyuridine Insertion in a Low-Virulence Classical Swine Fever Virus Triggers a Cytokine Storm and Lethal Disease

N. Ruggli, M. Gerber, L. Ganges, 2022, Journal of virology.

Abrogation of the RNase activity of Erns in a low virulence classical swine fever virus enhances the humoral immune response and reduces virulence, transmissibility, and persistence in pigs

N. Ruggli, M. Gerber, L. Ganges, 2021, Virulence.

Antiviral activity of K22 against members of the order Nidovirales

Christin Müller, J. Ziebuhr, N. Ruggli, 2018, Virus Research.

Novel poly-uridine insertion in the 3'UTR and E2 amino acid substitutions in a low virulent classical swine fever virus.

N. Ruggli, A. Grundhoff, D. Indenbirken, 2017, Veterinary microbiology.

Npro of classical swine fever virus contributes to pathogenicity in pigs by preventing type I interferon induction at local replication sites

N. Ruggli, Y. Sakoda, H. Kida, 2014, Veterinary Research.

Selection of Classical Swine Fever Virus with Enhanced Pathogenicity Reveals Synergistic Virulence Determinants in E2 and NS4B

N. Ruggli, Y. Sakoda, H. Kida, 2012, Journal of Virology.

Properties of H7N7 influenza A virus strain SC35M lacking interferon antagonist NS1 in mice and chickens.

G. Kochs, N. Ruggli, I. Koerner, 2007, The Journal of general virology.

Classical Swine Fever Virus N pro Interacts with Interferon Regulatory Factor 3 and Induces Its Proteasomal Degradation (cid:1)

J. Tratschin, N. Ruggli, Y. Sakoda, 2007 .

Experimental pigeon paramyxovirus-1 infection in chicken: evaluation of infectivity, clinical and pathological manifestations and diagnostic methods.

N. Ruggli, R. Hoop, S. Albini, 2020, The Journal of general virology.

Highly pathogenic avian influenza virus H5N1 controls type I IFN induction in chicken macrophage HD-11 cells: a polygenic trait that involves NS1 and the polymerase complex

N. Ruggli, Y. Sakoda, A. Summerfield, 2012, Virology Journal.

The developing T-cell compartment of the neonatal lung orchestrates an atypical response to respiratory syncytial virus

T. Démoulins, N. Ruggli, C. Benarafa, 2020 .

A cloned classical swine fever virus derived from the vaccine strain GPE- causes cytopathic effect in CPK-NS cells via type-I interferon-dependent necroptosis.

Y. Fujimoto, N. Ruggli, Y. Sakoda, 2019, Virus research.

Local Cellular Immune Responses and Pathogenesis of Buruli Ulcer Lesions in the Experimental Mycobacterium Ulcerans Pig Infection Model

N. Ruggli, G. Pluschke, N. Borel, 2016, PLoS neglected tropical diseases.

Classical Swine Fever Virus Can Remain Virulent after Specific Elimination of the Interferon Regulatory Factor 3-Degrading Function of N

J. Tratschin, N. Ruggli, Y. Sakoda, 2008 .

Classical swine fever virus interferes with cellular antiviral defense: evidence for a novel function of N(pro).

J. Tratschin, K. McCullough, M. Schweizer, 2003, Journal of virology.

Immune Responses Against Classical Swine Fever Virus: Between Ignorance and Lunacy

N. Ruggli, A. Summerfield, 2015, Front. Vet. Sci..

N(pro) of classical swine fever virus is an antagonist of double-stranded RNA-mediated apoptosis and IFN-alpha/beta induction.

J. Tratschin, N. Ruggli, B. Bird, 2005, Virology.

Zinc binding in pestivirus N(pro) is required for interferon regulatory factor 3 interaction and degradation.

J. Tratschin, N. Ruggli, Mengyi Ye, 2009, Journal of molecular biology.

Dendritic cells--at the front-line of pathogen attack.

K. McCullough, N. Ruggli, A. Summerfield, 2009, Veterinary immunology and immunopathology.

Mycoplasma contamination and viral immunomodulatory activity: dendritic cells open Pandora's box.

C. P. Carrasco, K. McCullough, N. Ruggli, 2007, Immunology letters.

Seroprevalence of Mycoplasma hyopneumoniae in sows fifteen years after implementation of a control programme for enzootic pneumonia in Switzerland.

K. Stärk, N. Ruggli, G. Overesch, 2022, Veterinary microbiology.

Classical swine fever virus: the past, present and future.

N. Ruggli, Y. Sakoda, H. Crooke, 2020, Virus research.

Development of an ELISA for the quantification of mycolactone, the cytotoxic macrolide toxin of Mycobacterium ulcerans

K. Altmann, N. Ruggli, G. Pluschke, 2020, PLoS neglected tropical diseases.

Genetic determinants of Sindbis virus neuroinvasiveness

C. Rice, J. Dubuisson, S. Lustig, 1997, Journal of virology.

Pulmonary mesenchymal stem cells are engaged in distinct steps of host response to respiratory syncytial virus infection

J. Éléouët, N. Ruggli, R. Schmid, 2021, bioRxiv.

Nucleotide sequence of classical swine fever virus strain Alfort/187 and transcription of infectious RNA from stably cloned full-length cDNA

J. Tratschin, N. Ruggli, M. Hofmann, 1996, Journal of virology.

A Broad RNA Virus Survey Reveals Both miRNA Dependence and Functional Sequestration.

J. Fak, R. Darnell, C. Rice, 2016, Cell host & microbe.

Functional RNA delivery targeted to dendritic cells by synthetic nanoparticles.

Isabelle Bassi, K. McCullough, N. Ruggli, 2012, Therapeutic delivery.

Baculovirus expression and affinity purification of protein E2 of classical swine fever virus strain Alfort/187

J. Tratschin, N. Ruggli, C. Moser, 2005, Virus Genes.

Correction: Efficient Sensing of Infected Cells in Absence of Virus Particles by Plasmacytoid Dendritic Cells Is Blocked by the Viral Ribonuclease Erns

N. Ruggli, R. Suter, M. Gerber, 2013, PLoS pathogens.

The N-terminal domain of Npro of classical swine fever virus determines its stability and regulates type I IFN production.

J. Tratschin, N. Ruggli, Y. Sakoda, 2015, The Journal of general virology.

Sensing of Porcine Reproductive and Respiratory Syndrome Virus-Infected Macrophages by Plasmacytoid Dendritic Cells

K. McCullough, N. Ruggli, A. Summerfield, 2016, Front. Microbiol..

Nonstructural proteins NS2-3 and NS4A of classical swine fever virus: essential features for infectious particle formation.

J. Tratschin, N. Ruggli, M. Hofmann, 2007, Virology.

Self-Amplifying Replicon RNA Vaccine Delivery to Dendritic Cells by Synthetic Nanoparticles

K. McCullough, Pavlos C. Englezou, N. Ruggli, 2014, Vaccines.

TNF-Mediated Inhibition of Classical Swine Fever Virus Replication Is IRF1-, NF-κB- and JAK/STAT Signaling-Dependent

N. Ruggli, M. Gerber, O. García-Nicolás, 2021, Viruses.

Classical Swine Fever Virus Interferes with Cellular Antiviral Defense: Evidence for a Novel Function of Npro

J. Tratschin, K. McCullough, M. Schweizer, 2003, Journal of Virology.

Experimental Infection of the Pig with Mycobacterium ulcerans: A Novel Model for Studying the Pathogenesis of Buruli Ulcer Disease

N. Ruggli, G. Zimmer, G. Pluschke, 2014, PLoS neglected tropical diseases.

Susceptibility of well-differentiated airway epithelial cell cultures from domestic and wildlife animals to SARS-CoV-2

N. Ruggli, V. Thiel, V. von Messling, 2020, bioRxiv.

Susceptibility of well-differentiated airway epithelial cell

N. Ruggli, V. Thiel, R. Dijkman, 2020 .

Pestivirus Npro Directly Interacts with Interferon Regulatory Factor 3 Monomer and Dimer

N. Ruggli, K. Choi, Keerthi Gottipati, 2016, Journal of Virology.

The Structure of Classical Swine Fever Virus Npro: A Novel Cysteine Autoprotease and Zinc-Binding Protein Involved in Subversion of Type I Interferon Induction

H. Bellamy, M. Benning, J. Tratschin, 2013, PLoS pathogens.

Identification of the role of RIG-I, MDA-5 and TLR3 in sensing RNA viruses in porcine epithelial cells using lentivirus-driven RNA interference.

N. Ruggli, A. Summerfield, M. Alves, 2011, Virus research.

Sequencing approach to analyze the role of quasispecies for classical swine fever.

Martin Beer, Armin Töpfer, Niko Beerenwinkel, 2013, Virology.

A poly-uridine insertion in the 3 ’-untranslated region of classical swine fever 1 virus activates immunity and reduces viral virulence in piglets 2

S. López-Soria, N. Ruggli, M. Gerber, 2019 .

Heterogeneous antigenic properties of the porcine reproductive and respiratory syndrome virus nucleocapsid

N. Ruggli, M. Hofmann, A. Summerfield, 2016, Veterinary Research.

Virus replicon particle vaccines expressing nucleoprotein of influenza A virus mediate enhanced inflammatory responses in pigs

N. Ruggli, G. Zimmer, A. Summerfield, 2017, Scientific Reports.

Reduced Virus Load in Lungs of Pigs Challenged with Porcine Reproductive and Respiratory Syndrome Virus after Vaccination with Virus Replicon Particles Encoding Conserved PRRSV Cytotoxic T-Cell Epitopes

L. Larsen, N. Ruggli, A. Summerfield, 2021, Vaccines.

Proteome-wide screening of the European porcine reproductive and respiratory syndrome virus reveals a broad range of T cell antigen reactivity.

N. Ruggli, S. Graham, J. Frossard, 2014, Vaccine.

Double‐stranded secondary structures on mRNA induce type I interferon (IFN α/β) production and maturation of mRNA‐transfected monocyte‐derived dendritic cells

K. McCullough, N. Ruggli, M. Ceppi, 2005, The journal of gene medicine.

Virus replicon particles expressing porcine reproductive and respiratory syndrome virus proteins elicit immune priming but do not confer protection from viremia in pigs

K. McCullough, N. Ruggli, G. Zimmer, 2016, Veterinary Research.

Self-replicating Replicon-RNA Delivery to Dendritic Cells by Chitosan-nanoparticles for Translation In Vitro and In Vivo

Isabelle Bassi, K. McCullough, Pavlos C. Englezou, 2014, Molecular therapy. Nucleic acids.

Detection of antibodies against classical swine fever virus in swine sera by indirect ELISA using recombinant envelope glycoprotein E2.

J. Tratschin, N. Ruggli, C. Moser, 1996, Veterinary microbiology.

Oronasal vaccination with classical swine fever virus (CSFV) replicon particles with either partial or complete deletion of the E2 gene induces partial protection against lethal challenge with highly virulent CSFV.

J. Tratschin, N. Ruggli, M. Hofmann, 2005, Vaccine.

Identification of classical swine fever virus protein E2 as a target for cytotoxic T cells by using mRNA-transfected antigen-presenting cells.

J. Tratschin, K. McCullough, N. Ruggli, 2005, The Journal of general virology.

Approaches to define the viral genetic basis of classical swine fever virus virulence.

S. Blome, N. Ruggli, Immanuel Leifer, 2013, Virology.

Clustering of classical swine fever virus isolates by codon pair bias

M. Beer, S. Blome, N. Ruggli, 2011, BMC Research Notes.

Functional cDNA clones of the Flaviviridae: strategies and applications.

C. Rice, N. Ruggli, 1999, Advances in virus research.

In-yeast reconstruction of the African swine fever virus genome isolated from clinical samples

N. Ruggli, H. Akarsu, J. Jores, 2021, STAR protocols.

Self-Amplifying Replicon RNA Delivery to Dendritic Cells by Cationic Lipids

K. McCullough, O. Zelphati, T. Ebensen, 2018, Molecular therapy. Nucleic acids.

Coatsome-replicon vehicles: Self-replicating RNA vaccines against infectious diseases.

K. McCullough, T. Ebensen, K. Schulze, 2023, Nanomedicine : nanotechnology, biology, and medicine.

Susceptibility of Well-Differentiated Airway Epithelial Cell Cultures from Domestic and Wild Animals to Severe Acute Respiratory Syndrome Coronavirus 2

N. Ruggli, V. Thiel, V. von Messling, 2021, Emerging infectious diseases.

Chicken Cells Sense Influenza A Virus Infection through MDA5 and CARDIF Signaling Involving LGP2

K. McCullough, N. Ruggli, G. Zimmer, 2011, Journal of Virology.

Intracellular membrane association of the N-terminal domain of classical swine fever virus NS4B determines viral genome replication and virulence.

N. Ruggli, Y. Sakoda, H. Kida, 2015, The Journal of general virology.

Sequencing approach to analyze the role of quasispecies for classical swine fever.

N. Beerenwinkel, M. Beer, S. Blome, 2013, Virology.

Reverse Genetic Assessment of the Roles Played by the Spike Protein and ORF3 in Porcine Epidemic Diarrhea Virus Pathogenicity

N. Ruggli, Jenna N. Kelly, N. Ebert, 2023, Journal of virology.

Evaluation of a novel intramuscular prime/intranasal boost vaccination strategy against influenza in the pig model

N. Ruggli, O. García-Nicolás, Robin Avanthay, 2024, PLoS pathogens.

Intramuscular prime/intranasal boost vaccination to induce sterilizing immunity against influenza A virus infection

N. Ruggli, O. García-Nicolás, Robin Avanthay, 2024, bioRxiv.

Fitness adaptations of Japanese encephalitis virus in pigs following vector-free serial passaging

N. Ruggli, O. García-Nicolás, Artur Summerfield, 2024, bioRxiv.

Functional surface expression of immunoglobulin cleavage systems in a candidate Mycoplasma vaccine chassis

N. Ruggli, H. Akarsu, Fabien Labroussaa, 2024, Communications biology.