I. Kopljar

发表

Voltage-sensor conformation shapes the intra-membrane drug binding site that determines gambierol affinity in Kv channels

J. Tytgat, A. Grottesi, I. Kopljar, 2016, Neuropharmacology.

Human-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop

Rebecca A. B. Burton, Matthew J. Daniels, Oliver J. Britton, 2015, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

Chronic drug‐induced effects on contractile motion properties and cardiac biomarkers in human induced pluripotent stem cell‐derived cardiomyocytes

I. Kopljar, A. de Bondt, Hua-rong Lu, 2017, British journal of pharmacology.

Pharmacological Profile of the Sodium Current in Human Stem Cell-Derived Cardiomyocytes Compares to Heterologous Nav1.5+β1 Model

I. Kopljar, A. Labro, D. Snyders, 2019, Front. Pharmacol..

Application of optical action potentials in human induced pluripotent stem cells-derived cardiomyocytes to predict drug-induced cardiac arrhythmias.

Godfrey L. Smith, H. R. Lu, I. Kopljar, 2017, Journal of pharmacological and toxicological methods.

Alkanols inhibit voltage-gated K+ channels via a distinct gating modifying mechanism that prevents gate opening

I. Kopljar, A. Labro, D. Snyders, 2015, Scientific Reports.

Gambierol, a toxin produced by the dinoflagellate Gambierdiscus toxicus, is a potent blocker of voltage-gated potassium channels.

J. Tytgat, E. Cuypers, I. Kopljar, 2008, Toxicon : official journal of the International Society on Toxinology.

Gambierol and n-alkanols inhibit Shaker Kv channel via distinct binding sites outside the K(+) pore.

J. Tytgat, I. Kopljar, J. Rainier, 2016, Toxicon : official journal of the International Society on Toxinology.

Gambierol and n-alkanols inhibit Shaker Kv channel via distinct binding sites outside the pore Reference:

J. Tytgat, I. Kopljar, J. Rainier, 2016 .

The ladder-shaped polyether toxin gambierol anchors the gating machinery of Kv3.1 channels in the resting state

J. Tytgat, I. Kopljar, J. Rainier, 2013, The Journal of general physiology.

The mechanism of action of microalgal toxins interacting with NaV and KV channels

J. Tytgat, I. Kopljar, D. Snyders, 2014 .

Functional and Transcriptional Characterization of Histone Deacetylase Inhibitor‐Mediated Cardiac Adverse Effects in Human Induced Pluripotent Stem Cell‐Derived Cardiomyocytes

Laure Cougnaud, An De Bondt, I. Kopljar, 2016, Stem cells translational medicine.

Purification, molecular cloning and functional characterization of HelaTx1 (Heterometrus laoticus): the first member of a new κ-KTX subfamily.

D. P. Jenkins, J. Tytgat, H. Wulff, 2012, Biochemical pharmacology.

Development of a Human iPSC Cardiomyocyte-Based Scoring System for Cardiac Hazard Identification in Early Drug Safety De-risking

I. Kopljar, Hua-rong Lu, D. Gallacher, 2018, Stem cell reports.

A polyether biotoxin binding site on the lipid-exposed face of the pore domain of Kv channels revealed by the marine toxin gambierol

J. Tytgat, E. Cuypers, I. Kopljar, 2009, Proceedings of the National Academy of Sciences.

P21-26 Anaphylactoid-resembling reactions in beagle dogs following oral (by gavage) administration of polyvinylpyrrolidone-co vinyl acetate (Kollidon® VA 64)

I. Kopljar, B. Feyen, M. Du Jardin, 2022, Toxicology Letters.

Impact of calcium-sensitive dyes on the beating properties and pharmacological responses of human iPS-derived cardiomyocytes using the calcium transient assay.

I. Kopljar, Hua-rong Lu, A. Hermans, 2018, Journal of pharmacological and toxicological methods.

The resting membrane potential of hSC-CM in a syncytium is more hyperpolarised than that of isolated cells

I. Kopljar, A. Labro, D. Snyders, 2021, Channels.

Use of the Actiwatch-Mini® in dog safety studies as an early indicator for drug-induced behavioural changes.

F. Cools, I. Kopljar, H. Borghys, 2020, Journal of pharmacological and toxicological methods.

Assessing drug-induced long QT and proarrhythmic risk using human stem cell-derived cardiomyocytes in a Ca2+ imaging assay: Evaluation of 28 CiPA compounds at three test sites.

Jennifer B Pierson, I. Kopljar, R. Kettenhofen, 2019, Toxicological sciences : an official journal of the Society of Toxicology.