D. Snyders

发表

Voltage-sensor conformation shapes the intra-membrane drug binding site that determines gambierol affinity in Kv channels

J. Tytgat, A. Grottesi, I. Kopljar, 2016, Neuropharmacology.

Mutations in the S6 gate isolate a late step in the activation pathway and reduce 4-AP sensitivity in shaker K(v) channel.

A. Labro, D. Snyders, E. Martínez-Morales, 2014, Biophysical journal.

Ibutilide, a methanesulfonanilide antiarrhythmic, is a potent blocker of the rapidly activating delayed rectifier K+ current (IKr) in AT-1 cells. Concentration-, time-, voltage-, and use-dependent effects.

D M Roden, D. Roden, T. Yang, 1995, Circulation.

Rapid inactivation determines the rectification and [K+]o dependence of the rapid component of the delayed rectifier K+ current in cardiac cells.

D M Roden, D. Roden, D. Snyders, 1997, Circulation research.

Hydrophobic Drug/Toxin Binding Sites in Voltage-Dependent K+ and Na+ Channels

A. Labro, D. Snyders, Kenny M. Van Theemsche, 2020, Frontiers in Pharmacology.

Dual Effect of Phosphatidyl (4,5)-Bisphosphate PIP2 on Shaker K+ Channels*

L. Delemotte, G. Loussouarn, A. Labro, 2012, The Journal of Biological Chemistry.

Evidence for multiple open and inactivated states of the hKv1.5 delayed rectifier.

D. Snyders, T. Rich, 1998, Biophysical journal.

Kv2.1 and silent Kv subunits underlie the delayed rectifier K+ current in cultured small mouse DRG neurons.

D. Snyders, A. Raes, E. Bocksteins, 2009, American journal of physiology. Cell physiology.

Mechanism of block of a human cardiac potassium channel by terfenadine racemate and enantiomers

D. Roden, C. Prakash, T. Yang, 1995, British journal of pharmacology.

Pharmacological Profile of the Sodium Current in Human Stem Cell-Derived Cardiomyocytes Compares to Heterologous Nav1.5+β1 Model

I. Kopljar, A. Labro, D. Snyders, 2019, Front. Pharmacol..

Alkanols inhibit voltage-gated K+ channels via a distinct gating modifying mechanism that prevents gate opening

I. Kopljar, A. Labro, D. Snyders, 2015, Scientific Reports.

Relevance of KCNE1, SCN5A and eNOS gene polymorphisms in Tunisian atrial fibrillation patients

A. Labro, D. Snyders, I. Trabelsi, 2018 .

The Subfamily-Specific Interaction between Kv2.1 and Kv6.4 Subunits Is Determined by Interactions between the N- and C-termini

J. Timmermans, D. Snyders, E. Bocksteins, 2014, PloS one.

Inhibition of cardiac potassium currents by the vesnarinone analog OPC-18790: comparison with quinidine and dofetilide.

D. Roden, D. Snyders, T. Yang, 1997, The Journal of pharmacology and experimental therapeutics.

A single hERG mutation underlying a spectrum of acquired and congenital long QT syndrome phenotypes.

A. Paulussen, J. Aerssens, D. Snyders, 2007, Journal of molecular and cellular cardiology.

K+ currents and K+ channel mRNA in cultured atrial cardiac myocytes (AT-1 cells).

D. Roden, D. Snyders, M. Tamkun, 1994, Circulation research.

Quinidine delays IK activation in guinea pig ventricular myocytes.

D. Roden, J. Balser, D. Snyders, 1988, Circulation research.

Gambierol, a toxin produced by the dinoflagellate Gambierdiscus toxicus, is a potent blocker of voltage-gated potassium channels.

J. Tytgat, E. Cuypers, I. Kopljar, 2008, Toxicon : official journal of the International Society on Toxinology.

Electrophysiological and pharmacological correspondence between Kv4.2 current and rat cardiac transient outward current.

D. Snyders, S. Yeola, Dirk J. Snyders, 1997, Cardiovascular research.

HERG mutation predicts short QT based on channel kinetics but causes long QT by heterotetrameric trafficking deficiency.

H. Smeets, A. Wilde, A. Paulussen, 2005, Cardiovascular research.

Gambierol and n-alkanols inhibit Shaker Kv channel via distinct binding sites outside the K(+) pore.

J. Tytgat, I. Kopljar, J. Rainier, 2016, Toxicon : official journal of the International Society on Toxinology.

The ladder-shaped polyether toxin gambierol anchors the gating machinery of Kv3.1 channels in the resting state

J. Tytgat, I. Kopljar, J. Rainier, 2013, The Journal of general physiology.

Stereoselective block of a human cardiac potassium channel (Kv1.5) by bupivacaine enantiomers.

J. Tamargo, D. Snyders, M. Tamkun, 1995, Biophysical journal.

Distinct domains of the voltage-gated K+ channel Kv beta 1.3 beta-subunit affect voltage-dependent gating.

V. Uebele, D. Snyders, M. Tamkun, 1998, The American journal of physiology.

The nonconducting W434F mutant adopts upon membrane depolarization an inactivated-like state that differs from wild-type Shaker-IR potassium channels

A. Labro, D. Snyders, E. Martínez-Morales, 2022, Science advances.

Functional effects of a KCNQ1 mutation associated with the long QT syndrome.

D. Snyders, A. Raes, I. Boulet, 2006, Cardiovascular research.

The S4-S5 Linker of KCNQ1 Channels Forms a Structural Scaffold with the S6 Segment Controlling Gate Closure*

G. Loussouarn, A. Labro, D. Snyders, 2010, The Journal of Biological Chemistry.

Differential expression of Isk mRNAs in mouse tissue during development and pregnancy.

D. Snyders, M. Tamkun, A. Felipe, 1994, The American journal of physiology.

Molecular analysis of a binding site for quinidine in a human cardiac delayed rectifier K+ channel. Role of S6 in antiarrhythmic drug binding.

V. Uebele, D. Snyders, M. Tamkun, 1996, Circulation research.

Effects of a quaternary bupivacaine derivative on delayed rectifier K+ currents

J. Tamargo, D. Snyders, M. Tamkun, 2000, British journal of pharmacology.

Benzocaine enhances and inhibits the K+ current through a human cardiac cloned channel (Kv1.5).

J. Tamargo, D. Snyders, R. Caballero, 1999, Cardiovascular research.

Targeted deletion of the Kv6.4 subunit causes male sterility due to disturbed spermiogenesis.

J. Timmermans, D. Snyders, I. Pintelon, 2017, Reproduction, fertility, and development.

Block of human cardiac Kv1.5 channels by loratadine: voltage-, time- and use-dependent block at concentrations above therapeutic levels.

J. Tamargo, D. Snyders, E. Delpón, 1997, Cardiovascular research.

The anticonvulsant retigabine suppresses neuronal KV2-mediated currents

D. Snyders, N. Schmitt, E. Bocksteins, 2016, Scientific Reports.

Offsetting Voltage-Dependent Kv1.5 Channel Opening Through Charged Residue Substitutions on Top of the First Transmembrane Segment

A. Labro, D. Snyders, E. Martínez-Morales, 2022, Bioelectricity.

Effects of quinidine on the sodium current of guinea pig ventricular myocytes. Evidence for a drug-associated rested state with altered kinetics.

D. Snyders, L. Hondeghem, 1990, Circulation research.

Temperature and Voltage Dependence of Sodium Channel Blocking and Unblocking by O-Demethyl Encainide in Isolated Guinea Pig Myocytes

D. Snyders, P. Bennett, L. Hondeghem, 1989, Journal of cardiovascular pharmacology.

Functional antagonism of alpha-subunits of Kv channel in developing brain ventricular system

D. Snyders, I. Kondrychyn, E. Bocksteins, 2016 .

A rapidly activating and slowly inactivating potassium channel cloned from human heart. Functional analysis after stable mammalian cell culture expression

D. Snyders, M. Tamkun, P. Bennett, 1993, The Journal of general physiology.

Influence of cloned voltage-gated K+ channel expression on alanine transport, Rb+ uptake, and cell volume.

D. Snyders, M. Tamkun, A. Felipe, 1993, The American journal of physiology.

Cloning and expression of human cardiac K^{+} channels

D. Snyders, M. Tamkun, P. Bennett, 1994 .

Functional expression of an inactivating potassium channel (Kv4.3) in a mammalian cell line.

J. Tamargo, J. Eck, D. Snyders, 1999, Cardiovascular research.

Constitutive, Basal, and β-Alanine-Mediated Activation of the Human Mas-Related G Protein-Coupled Receptor D Induces Release of the Inflammatory Cytokine IL-6 and Is Dependent on NF-κB Signaling.

R. Arora, J. Timmermans, A. Labro, 2021, International journal of molecular sciences.

Effects of Ropivacaine on a Potassium Channel (hKv1.5) Cloned from Human Ventricle

J. Tamargo, D. Snyders, E. Delpón, 1997, Anesthesiology.

Stereoselective block of cardiac sodium channels by bupivacaine in guinea pig ventricular myocytes.

J. Tamargo, D. Snyders, P. Bennett, 1995, Circulation.

Obligatory heterotetramerization of three previously uncharacterized Kv channel α-subunits identified in the human genome

D. Snyders, A. Raes, D. van Hoorick, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Quantitative single-cell ion-channel gene expression profiling through an improved qRT-PCR technique combined with whole cell patch clamp

E. De Schutter, E. Schutter, A. Labro, 2012, Journal of Neuroscience Methods.

A Novel Mutation (T65P) in the PAS Domain of the Human Potassium Channel HERG Results in the Long QT Syndrome by Trafficking Deficiency*

A. Paulussen, J. Aerssens, G. Matthijs, 2002, The Journal of Biological Chemistry.

Structure and function of cardiac potassium channels.

D. Snyders, D J Snyders, Dirk J. Snyders, 1999, Cardiovascular research.

Functional antagonism of voltage-gated K+ channel α-subunits in the developing brain ventricular system

V. Korzh, D. Snyders, I. Kondrychyn, 2016, Development.

The mechanism of action of microalgal toxins interacting with NaV and KV channels

J. Tytgat, I. Kopljar, D. Snyders, 2014 .

Molecular determinants of stereoselective bupivacaine block of hKv1.5 channels.

J. Tamargo, D. Snyders, M. Tamkun, 1997, Circulation research.

The contribution of genes involved in potassium‐recycling in the inner ear to noise‐induced hearing loss

M. Bondeson, E. Fransen, D. Snyders, 2006, Human mutation.

Optical Mapping in hiPSC-CM and Zebrafish to Resolve Cardiac Arrhythmias

B. Loeys, D. Snyders, M. Alaerts, 2020 .

Clinical and functional characterisation of a recurrent KCNQ1 variant in the Belgian population

B. Loeys, A. Labro, D. Snyders, 2023, Orphanet Journal of Rare Diseases.

High affinity open channel block by dofetilide of HERG expressed in a human cell line.

D. Snyders, D J Snyders, A Chaudhary, 1996, Molecular pharmacology.

Improved selection of zebrafish CRISPR editing by early next-generation sequencing based genotyping

B. Loeys, D. Snyders, M. Alaerts, 2023, Scientific Reports.

Purification, molecular cloning and functional characterization of HelaTx1 (Heterometrus laoticus): the first member of a new κ-KTX subfamily.

D. P. Jenkins, J. Tytgat, H. Wulff, 2012, Biochemical pharmacology.

K' Channel by Protein Kinase C

K. Murray, D. Snyders, M. Tamkun, 2005 .

Modulation of an inactivating human cardiac K+ channel by protein kinase C.

K. Murray, D. Snyders, M. Tamkun, 1994, Circulation research.

A K+ Channel Splice Variant Common in Human Heart Lacks a C-terminal Domain Required for Expression of Rapidly Activating Delayed Rectifier Current*

D. Roden, D. Snyders, S. Kupershmidt, 1998, The Journal of Biological Chemistry.

Distinct domains of the voltage-gated K+ channel Kvβ1.3 β-subunit affect voltage-dependent gating.

V. Uebele, D. Snyders, M. Tamkun, 1998, American journal of physiology. Cell physiology.

Voltage-gated delayed rectifier Kv1-subunits may serve as distinctive markers for enteroglial cells with different phenotypes in the murine ileum

D. Adriaensen, J. Timmermans, D. Snyders, 2009, Neuroscience Letters.

Independent movement of the voltage sensors in KV2.1/KV6.4 heterotetramers

D. Snyders, M. Holmgren, E. Bocksteins, 2017, Scientific Reports.

Class III antiarrhythmic agents have a lot of potential but a long way to go. Reduced effectiveness and dangers of reverse use dependence.

D. Snyders, L. Hondeghem, 1990, Circulation.

Effects of 4-aminopyridine on inward rectifying and pacemaker currents of cardiac purkinje fibres

D. Snyders, P. Bogaert, 1982, Pflügers Archiv.

Brief Communication Quinidine Delays I K Activation in Guinea Pig Ventricular Myocytes

D. Roden, J. Balser, D. Snyders, 2005 .

Morpho-functional comparison of differentiation protocols to create iPSC-derived cardiomyocytes

H. Heidbuchel, W. D. De Vos, E. Fransen, 2022, Biology open.

Kv3 channels contribute to the delayed rectifier current in small cultured mouse dorsal root ganglion neurons.

D. Snyders, E. Bocksteins, G. Van de Vijver, 2012, American journal of physiology. Cell physiology.

Domain analysis of Kv6.3, an electrically silent channel

J. Timmermans, D. Snyders, A. Raes, 2005, The Journal of physiology.

Kv3.1 uses a timely resurgent K+ current to secure action potential repolarization

F. Bezanilla, M. Priest, A. Labro, 2015, Nature Communications.

Molecular mechanism for depolarization-induced modulation of Kv channel closure

F. Bezanilla, A. Labro, D. Snyders, 2012, The Journal of general physiology.

Functional interactions between residues in the S1, S4, and S5 domains of Kv2.1

J. Timmermans, A. Labro, D. Snyders, 2011, European Biophysics Journal.

A polyether biotoxin binding site on the lipid-exposed face of the pore domain of Kv channels revealed by the marine toxin gambierol

J. Tytgat, E. Cuypers, I. Kopljar, 2009, Proceedings of the National Academy of Sciences.

Coupling of Voltage Sensing to Channel Opening Reflects Intrasubunit Interactions in Kv Channels

A. Labro, D. Snyders, A. Raes, 2005, The Journal of general physiology.

Gating of Shaker-type Channels Requires the Flexibility of S6 Caused by Prolines*

A. Labro, D. Snyders, A. Raes, 2003, Journal of Biological Chemistry.

The Electrically Silent Kv6.4 Subunit Confers Hyperpolarized Gating Charge Movement in Kv2.1/Kv6.4 Heterotetrameric Channels

D. Mohapatra, A. Labro, D. Snyders, 2012, PloS one.

Functional Differences in Kv1.5 Currents Expressed in Mammalian Cell Lines Are Due to the Presence of Endogenous Kvβ2.1 Subunits (*)

V. Uebele, D. Snyders, M. Tamkun, 1996, The Journal of Biological Chemistry.

Heteromultimeric assembly of human potassium channels. Molecular basis of a transient outward current?

S. Roberds, D. Snyders, M. Tamkun, 1993, Circulation research.

A Kv channel with an altered activation gate sequence displays both "fast" and "slow" activation kinetics.

M. Sansom, A. Grottesi, A. Labro, 2008, American journal of physiology. Cell physiology.

Effects of antiarrhythmic drugs on cloned cardiac voltage-gated potassium channels expressed in Xenopus oocytes

G. Breithardt, W. Haverkamp, L. Eckardt, 2000, Naunyn-Schmiedeberg's Archives of Pharmacology.

The rate-dependent biophysical properties of the LQT1 H258R mutant are counteracted by a dominant negative effect on channel trafficking.

J. Timmermans, A. Labro, D. Snyders, 2010, Journal of molecular and cellular cardiology.

Molecular Biology of the Voltage‐Gated Potassium Channels of the Cardiovascular System

S. Roberds, D. Snyders, M. Tamkun, 1993, Journal of cardiovascular electrophysiology.

KCNQ1 Channels Voltage Dependence through a Voltage-dependent Binding of the S4-S5 Linker to the Pore Domain*

D. Escande, F. Charpentier, G. Loussouarn, 2010, The Journal of Biological Chemistry.

Modulation of HERG gating by a charge cluster in the N-terminal proximal domain.

A. Labro, D. Snyders, A. Raes, 2006, Biophysical journal.

Drug Block of I Kr : Model Systems and Relevance to Human Arrhythmias

D. Roden, T. Yang, D. Snyders, 2001, Journal of cardiovascular pharmacology.

Immunostaining of Voltage-Gated Ion Channels in Cell Lines and Neurons – Key Concepts and Potential Pitfalls

D. Mohapatra, D. Snyders, A. Shepherd, 2012 .

1 Immunostaining of Voltage-Gated Ion Channels in Cell Lines and Neurons – Key Concepts and Potential Pitfalls

D. Mohapatra, D. Snyders, A. Shepherd, 2017 .

Kv Channel Gating Requires a Compatible S4-S5 Linker and Bottom Part of S6, Constrained by Non-interacting Residues

M. Sansom, A. Grottesi, A. Labro, 2008, The Journal of general physiology.

Determinants of antiarrhythmic drug action. Electrostatic and hydrophobic components of block of the human cardiac hKv1.5 channel.

D. Snyders, S. Yeola, Dirk J. Snyders, 1995, Circulation research.

Electrically silent Kv subunits: their molecular and functional characteristics.

D. Snyders, E. Bocksteins, 2012, Physiology.

Kv3.3b expression defines the shape of the complex spike in the Purkinje cell

E. Schutter, D. Snyders, K. Veys, 2013, Front. Cell. Neurosci..

Class III antiarrhythmic effects of zatebradine. Time-, state-, use-, and voltage-dependent block of hKv1.5 channels.

J. Tamargo, D. Snyders, E. Delpón, 1996, Circulation.

Determining the correct stoichiometry of Kv2.1/Kv6.4 heterotetramers, functional in multiple stoichiometrical configurations

A. Labro, D. Snyders, R. Blunck, 2020, Proceedings of the National Academy of Sciences.

The interactions of apamin and tetraethylammonium are differentially affected by single mutations in the pore mouth of small conductance calcium-activated potassium (SK) channels.

D. Snyders, Cédric Lamy, S. Dilly, 2013, Biochemical pharmacology.

Transient Outward Current?

S. Roberds, D. Snyders, M. Tamkun, 2005 .

Role of the S6 C‐terminus in KCNQ1 channel gating

A. Labro, D. Snyders, A. Raes, 2007, The Journal of physiology.

Modulation of Closed−State Inactivation in Kv2.1/Kv6.4 Heterotetramers as Mechanism for 4−AP Induced Potentiation

A. Labro, D. Snyders, E. Bocksteins, 2015, PloS one.

Functional Characteristics Electrically Silent Kv Subunits : Their Molecular and

D. Snyders, E. Bocksteins, 2012 .

The aromatic cluster in KCHIP1b affects Kv4 inactivation gating

D. Snyders, A. Raes, D. van Hoorick, 2007, The Journal of physiology.

The resting membrane potential of hSC-CM in a syncytium is more hyperpolarised than that of isolated cells

I. Kopljar, A. Labro, D. Snyders, 2021, Channels.

Compound Heterozygous SCN5A Mutations in Severe Sodium Channelopathy With Brugada Syndrome: A Case Report

J. Tytgat, B. Loeys, A. Labro, 2020, Frontiers in Cardiovascular Medicine.

Dromedary immune response and specific Kv2.1 antibody generation using a specific immunization approach.

S. Muyldermans, A. Labro, D. Snyders, 2016, International journal of biological macromolecules.

Being Flexible: The Voltage-Controllable Activation Gate of Kv Channels

A. Labro, D. Snyders, 2012, Front. Pharmacol..

Kv3 channels contribute to the delayed rectifier current in small cultured mouse dorsal root ganglion neurons.

D. Snyders, E. Bocksteins, G. Van de Vijver, 2012, American journal of physiology. Cell physiology.

Mutations throughout the S6 region of the hKv1.5 channel alter the stability of the activation gate.

D. Snyders, M. Tamkun, T. Rich, 2002, American journal of physiology. Cell physiology.

Alinidine modifies the pacemaker current in sheep Purkinje fibers

D. Snyders, P. Bogaert, 1987, Pflügers Archiv.

The Selectivity Filter Is Involved in the U-Type Inactivation Process of Kv2.1 and Kv3.1 Channels

Nicolas De Neuter, A. Labro, D. Snyders, 2020, Biophysical journal.

Targeted deletion of the Kv6.4 subunit causes male sterility due to disturbed spermiogenesis.

J. Timmermans, D. Snyders, I. Pintelon, 2017, Reproduction, fertility, and development.

The contribution of Kv2.2‐mediated currents decreases during the postnatal development of mouse dorsal root ganglion neurons

D. Snyders, E. Bocksteins, G. Van de Vijver, 2016, Physiological reports.

Electrically silent Kv subunits: their molecular and functional characteristics.

D. Snyders, E. Bocksteins, Elke Bocksteins, 2012, Physiology.

Functional expression of an inactivating potassium channel cloned from human heart.

D. Snyders, M. Tamkun, P. Bennett, 1992, Circulation research.

in small cultured mouse dorsal root ganglion neurons 3 channels contribute to the delayed rectifier current

D. Snyders, E. Bocksteins, G. Vijver, 2016 .

Differential modulation of Kv4 kinetics by KCHIP1 splice variants

D. Snyders, A. Raes, E. Mayeur, 2003, Molecular and Cellular Neuroscience.

Functional and pharmacological diversity of mammalian potassium channels: a molecular approach

D. Snyders, 1995 .

Intracellular pH transients induced by chloride substitution in cardiac Purkyne fibres [proceedings].

D. Snyders, P. van Bogaert, 1979, Archives internationales de physiologie et de biochimie.

Molecular and functional diversity of cloned cardiac potassium channels

D. Snyders, M. Tamkun, P. Bennett, 1993, Cardiovascular Drugs and Therapy.

Kv2.1 and silent Kv subunits underlie the delayed rectifier K+ current in cultured small mouse DRG neurons.

D. Snyders, A. Raes, G. Van de Vijver, 2009, American journal of physiology. Cell physiology.

Coupling of Voltage Sensing to Channel Opening Reflects Intrasubunit Interactions in Kv Channels

A. Labro, D. Snyders, A. Raes, 2005, The Journal of general physiology.

Mechanisms of block of a human cloned potassium channel by the enantiomers of a new bradycardic agent: S‐16257‐2 and S‐16260‐2

J. Tamargo, D. Snyders, E. Delpón, 1996, British journal of pharmacology.