Yusuke Sato

发表

Cellular environment-responsive nanomaterials for use in gene and siRNA delivery: molecular design for biomembrane destabilization and intracellular collapse

H. Harashima, Hiroki Tanaka, Yusuke Sato, 2016, Expert opinion on drug delivery.

Lipid nanoparticles fuse with cell membranes of immune cells at low temperatures leading to the loss of transfection activity.

Takashi Nakamura, H. Harashima, Yusuke Sato, 2020, International journal of pharmaceutics.

Endosomal escape and the knockdown efficiency of liposomal-siRNA by the fusogenic peptide shGALA.

S. Futaki, H. Harashima, Yusuke Sato, 2011, Biomaterials.

The silencing of indoleamine 2,3-dioxygenase 1 (IDO1) in dendritic cells by siRNA-loaded lipid nanoparticles enhances cell-based cancer immunotherapy

Takashi Nakamura, H. Harashima, Yusuke Sato, 2019, Scientific Reports.

In vivo therapeutic potential of Dicer-hunting siRNAs targeting infectious hepatitis C virus.

Y. Hirata, M. Kohara, H. Harashima, 2014, Scientific Reports.

Development of the iLiNP Device: Fine Tuning the Lipid Nanoparticle Size within 10 nm for Drug Delivery

Manabu Tokeshi, Akihiko Ishida, Hideyoshi Harashima, 2018, ACS omega.

Elucidation of the physicochemical properties and potency of siRNA-loaded small-sized lipid nanoparticles for siRNA delivery.

N. Kaji, M. Tokeshi, Y. Baba, 2016, Journal of controlled release : official journal of the Controlled Release Society.

New Design Strategies for Controlling the Rate of Hydrophobic Drug Release from Nanoemulsions in Blood Circulation.

H. Harashima, Saed Abbasi, Yusuke Sato, 2020, Molecular pharmaceutics.

Lung‐Endothelium‐Targeted Nanoparticles Based on a pH‐Sensitive Lipid and the GALA Peptide Enable Robust Gene Silencing and the Regression of Metastatic Lung Cancer

I. Khalil, H. Harashima, Yusuke Sato, 2019, Advanced Functional Materials.

Highly specific delivery of siRNA to hepatocytes circumvents endothelial cell‐mediated lipid nanoparticle‐associated toxicity leading to the safe and efficacious decrease in the hepatitis B virus

M. Kohara, H. Harashima, Yusuke Sato, 2017, Journal of controlled release : official journal of the Controlled Release Society.

The RNA sensor RIG-I dually functions as an innate sensor and direct antiviral factor for hepatitis B virus.

C. Rice, A. Takaoka, M. Kohara, 2015, Immunity.

A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo.

H. Harashima, Yusuke Sato, H. Akita, 2012, Journal of controlled release : official journal of the Controlled Release Society.

Innovative nanotechnologies for enhancing nucleic acids/gene therapy: Controlling intracellular trafficking to targeted biodistribution.

Takashi Nakamura, I. Khalil, H. Harashima, 2019, Biomaterials.

Understanding structure‐activity relationships of pH‐sensitive cationic lipids facilitates the rational identification of promising lipid nanoparticles for delivering siRNAs in vivo

M. Tokeshi, Masatoshi Maeki, H. Harashima, 2019, Journal of controlled release : official journal of the Controlled Release Society.

Hydrophobic scaffolds of pH-sensitive cationic lipids contribute to miscibility with phospholipids and improve the efficiency of delivering short interfering RNA by small-sized lipid nanoparticles.

M. Tokeshi, Masatoshi Maeki, H. Harashima, 2019, Acta biomaterialia.

An apolipoprotein E modified liposomal nanoparticle: ligand dependent efficiency as a siRNA delivery carrier for mouse-derived brain endothelial cells.

H. Harashima, Yusuke Sato, H. Akita, 2014, International journal of pharmaceutics.

Title : A new adjuvant delivery system ' cyclic di-GMP / YSK 05 liposome ' for cancer immunotherapy

Takashi Nakamura, H. Harashima, Yusuke Sato, 2018 .

A new adjuvant delivery system 'cyclic di-GMP/YSK05 liposome' for cancer immunotherapy.

Takashi Nakamura, H. Harashima, Yusuke Sato, 2014, Journal of controlled release : official journal of the Controlled Release Society.

BPB Reports

H. Harashima, Yusuke Sato, N. Maishi, 2019 .

Size-Dependency of the Surface Ligand Density of Liposomes Prepared by Post-insertion.

H. Harashima, Yusuke Sato, M. Hyodo, 2017, Biological & pharmaceutical bulletin.

Advances in microfluidics for lipid nanoparticles and extracellular vesicles and applications in drug delivery systems☆

M. Tokeshi, Masatoshi Maeki, H. Harashima, 2018, Advanced drug delivery reviews.

Extrahepatic targeting of lipid nanoparticles in vivo with intracellular targeting for future nanomedicines.

Takashi Nakamura, H. Harashima, Yusuke Sato, 2022, Advanced drug delivery reviews.

PEGylation of the GALA Peptide Enhances the Lung-Targeting Activity of Nanocarriers That Contain Encapsulated siRNA.

H. Harashima, Yusuke Sato, K. Kusumoto, 2017, Journal of pharmaceutical sciences.

Liver-Specific Silencing of Lipin1 Reduces Fat Mass as Well as Hepatic Triglyceride Biosynthesis in Mice.

H. Harashima, Yusuke Sato, K. Kajimoto, 2016, Biological & pharmaceutical bulletin.

The hydrophobic tail of a pH-sensitive cationic lipid influences siRNA transfection activity and toxicity in human NK cell lines.

Takashi Nakamura, H. Harashima, Yusuke Sato, 2021, International journal of pharmaceutics.

The Use of a Microfluidic Device to Encapsulate a Poorly Water-Soluble Drug CoQ10 in Lipid Nanoparticles and an Attempt to Regulate Intracellular Trafficking to Reach Mitochondria.

M. Tokeshi, Masatoshi Maeki, H. Harashima, 2019, Journal of pharmaceutical sciences.

mRNA-Loaded Lipid Nanoparticles Targeting Dendritic Cells for Cancer Immunotherapy

H. Harashima, Yusuke Sato, Kosuke Sasaki, 2022, Pharmaceutics.

Novel pH-sensitive multifunctional envelope-type nanodevice for siRNA-based treatments for chronic HBV infection.

K. Chayama, Y. Hirata, M. Kohara, 2016, Journal of hepatology.

Preparation of envelope-type lipid nanoparticles containing gold nanorods for photothermal cancer therapy.

H. Harashima, Hiroki Tanaka, Yusuke Sato, 2017, Colloids and surfaces. B, Biointerfaces.

A Neutral Envelope‐Type Nanoparticle Containing pH‐Responsive and SS‐Cleavable Lipid‐Like Material as a Carrier for Plasmid DNA

H. Harashima, Hiroki Tanaka, Yusuke Sato, 2013, Advanced healthcare materials.

STING agonist loaded lipid nanoparticles overcome anti-PD-1 resistance in melanoma lung metastasis via NK cell activation

Takashi Nakamura, H. Harashima, Yusuke Sato, 2021, Journal for ImmunoTherapy of Cancer.

Innovative cancer nanomedicine based on immunology, gene editing, intracellular trafficking control.

Takashi Nakamura, H. Harashima, Yusuke Sato, 2022, Journal of controlled release : official journal of the Controlled Release Society.

Manipulating the function of tumor-associated macrophages by siRNA-loaded lipid nanoparticles for cancer immunotherapy.

H. Harashima, Yusuke Sato, Yuichi Suzuki, 2020, Journal of controlled release : official journal of the Controlled Release Society.

On the size-regulation of RNA-loaded lipid nanoparticles synthesized by microfluidic device.

M. Tokeshi, Masatoshi Maeki, H. Harashima, 2022, Journal of controlled release : official journal of the Controlled Release Society.

Mitochondrial Delivery of Doxorubicin Using MITO-Porter Kills Drug-Resistant Renal Cancer Cells via Mitochondrial Toxicity.

H. Harashima, Yusuke Sato, Yuma Yamada, 2017, Journal of pharmaceutical sciences.

The use of design of experiments with multiple responses to determine optimal formulations for in vivo hepatic mRNA delivery.

M. Tokeshi, Masatoshi Maeki, H. Harashima, 2020, Journal of controlled release : official journal of the Controlled Release Society.

Neutralization of negative charges of siRNA results in improved safety and efficient gene silencing activity of lipid nanoparticles loaded with high levels of siRNA

H. Harashima, Yusuke Sato, H. Matsui, 2018, Journal of controlled release : official journal of the Controlled Release Society.

Lipid nanoparticles loaded with ribonucleoprotein-oligonucleotide complexes synthesized using a microfluidic device exhibit robust genome editing and hepatitis B virus inhibition.

M. Tokeshi, Masatoshi Maeki, M. Kohara, 2020, Journal of controlled release : official journal of the Controlled Release Society.

Retrograde Axonal Transport of Liposomes from Peripheral Tissue to Spinal Cord and DRGs by Optimized Phospholipid and CTB Modification

N. Iwasaki, Takashi Nakamura, H. Harashima, 2022, International journal of molecular sciences.

The effect of size and charge of lipid nanoparticles prepared by microfluidic mixing on their lymph node transitivity and distribution.

M. Tokeshi, Masatoshi Maeki, Takashi Nakamura, 2020, Molecular pharmaceutics.

A study of the endocytosis mechanism and transendothelial activity of lung-targeted GALA-modified liposomes.

I. Khalil, H. Harashima, Yusuke Sato, 2019, Journal of controlled release : official journal of the Controlled Release Society.

Non-Viral Gene Therapy in Trabecular Meshwork Cells to Prevent Fibrosis in Minimally Invasive Glaucoma Surgery

C. Yu-Wai-Man, C. Sheridan, H. Harashima, 2022, Pharmaceutics.

Branching Ionizable Lipids Can Enhance the Stability, Fusogenicity, and Functional Delivery of mRNA

H. Harashima, Yusuke Sato, A. Okazaki, 2022, Small Science.

Synergism between a cell penetrating peptide and a pH‐sensitive cationic lipid in efficient gene delivery based on double‐coated nanoparticles

I. Khalil, H. Harashima, Yusuke Sato, 2018, Journal of controlled release : official journal of the Controlled Release Society.

Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanoma.

Takashi Nakamura, H. Harashima, Yusuke Sato, 2015, Journal of controlled release : official journal of the Controlled Release Society.

The systemic administration of an anti-miRNA oligonucleotide encapsulated pH-sensitive liposome results in reduced level of hepatic microRNA-122 in mice.

N. Minakawa, A. Matsuda, H. Harashima, 2014, Journal of controlled release : official journal of the Controlled Release Society.

The nanomedicine rush: New strategies for unmet medical needs based on innovative nano DDS.

Takashi Nakamura, H. Harashima, Yusuke Sato, 2020, Journal of controlled release : official journal of the Controlled Release Society.

Combined nano cancer immunotherapy based on immune status in a tumor microenvironment.

Takashi Nakamura, H. Harashima, Yusuke Sato, 2022, Journal of controlled release : official journal of the Controlled Release Society.

Inhibitory Effect of a Human MicroRNA, miR-6133-5p, on the Fibrotic Activity of Hepatic Stellate Cells in Culture

K. Matsuura, Susumu Hamada-Tsutsumi, Yasuhito Tanaka, 2020, International journal of molecular sciences.

Innovative Technologies in Nanomedicines: From Passive Targeting to Active Targeting/From Controlled Pharmacokinetics to Controlled Intracellular Pharmacokinetics.

Takashi Nakamura, H. Harashima, Yusuke Sato, 2017, Macromolecular bioscience.

Development of a multifunctional envelope-type nano device and its application to nanomedicine.

Takashi Nakamura, H. Harashima, Yusuke Sato, 2016, Journal of controlled release : official journal of the Controlled Release Society.

A lipid nanoparticle for the efficient delivery of siRNA to dendritic cells.

Hideyoshi Harashima, Hiroto Hatakeyama, Takashi Nakamura, 2016, Journal of controlled release : official journal of the Controlled Release Society.

The systemic administration of an anti-miRNA oligonucleotide encapsulated pH-sensitive liposome results in reduced level of hepatic microRNA-122 in mice.

N. Minakawa, A. Matsuda, H. Harashima, 2014, Journal of controlled release : official journal of the Controlled Release Society.

Development of Lipid Nanoparticles for the Delivery of Macromolecules Based on the Molecular Design of pH-Sensitive Cationic Lipids.

Yusuke Sato, 2021, Chemical & pharmaceutical bulletin.

In vitro optimization of 2′-OMe-4′-thioribonucleoside–modified anti-microRNA oligonucleotides and its targeting delivery to mouse liver using a liposomal nanoparticle

N. Minakawa, A. Matsuda, H. Harashima, 2013, Nucleic acids research.

Mitochondrial delivery of an anticancer drug via systemic administration using a mitochondrial delivery system that inhibits the growth of drug-resistant cancer engrafted on mice.

H. Harashima, Yusuke Sato, Yuma Yamada, 2020, Journal of pharmaceutical sciences.

Gene silencing via RNAi and siRNA quantification in tumor tissue using MEND, a liposomal siRNA delivery system.

H. Harashima, Yusuke Sato, H. Akita, 2013, Molecular therapy : the journal of the American Society of Gene Therapy.

Multifunctional enveloped nanodevices (MENDs).

Takashi Nakamura, H. Harashima, Yusuke Sato, 2014, Advances in genetics.

Anti-tumor effect via passive anti-angiogenesis of PEGylated liposomes encapsulating doxorubicin in drug resistant tumors.

G. Kibria, H. Harashima, Yusuke Sato, 2016, International journal of pharmaceutics.

Understanding the formation mechanism of lipid nanoparticles in microfluidic devices with chaotic micromixers

Noritada Kaji, Manabu Tokeshi, Yoshinobu Baba, 2017, PloS one.

Lipid nanoparticle-based ribonucleoprotein delivery for in vivo genome editing.

H. Harashima, Yusuke Sato, Haruno Onuma, 2023, Journal of controlled release : official journal of the Controlled Release Society.

Interferon signaling suppresses the unfolded protein response and induces cell death in hepatocytes accumulating hepatitis B surface antigen

Hiroyasu Ito, T. Ishikawa, Yasuhito Tanaka, 2020, bioRxiv.

Size-dependent specific targeting and efficient gene silencing in peritoneal macrophages using a pH-sensitive cationic liposomal siRNA carrier.

H. Harashima, Yusuke Sato, H. Akita, 2015, International journal of pharmaceutics.

Instructions for use Title Hepatic Monoacylglycerol O-acyltransferase 1 as a PromisingTherapeutic Target for Steatosis , Obesity , and Type 2 Diabetes

N. Kaji, Y. Baba, H. Harashima, 2017 .

Hepatic Monoacylglycerol O-acyltransferase 1 as a Promising Therapeutic Target for Steatosis, Obesity, and Type 2 Diabetes

N. Kaji, Y. Baba, H. Harashima, 2014, Molecular therapy. Nucleic acids.

Mass production system for RNA-loaded lipid nanoparticles using piling up microfluidic devices

M. Tokeshi, Masatoshi Maeki, A. Ishida, 2023, Applied Materials Today.

Three-dimensional, symmetrically assembled microfluidic device for lipid nanoparticle production

M. Tokeshi, Masatoshi Maeki, A. Ishida, 2021, RSC advances.

Different kinetics for the hepatic uptake of lipid nanoparticles between the apolipoprotein E/low density lipoprotein receptor and the N-acetyl-d-galactosamine/asialoglycoprotein receptor pathway.

H. Harashima, Yusuke Sato, Kazuki Hashiba, 2020, Journal of controlled release : official journal of the Controlled Release Society.

Molecular Tuning of a Vitamin E-Scaffold pH-Sensitive and Reductive Cleavable Lipid-like Material for Accelerated in Vivo Hepatic siRNA Delivery.

H. Harashima, Yusuke Sato, H. Akita, 2015, ACS biomaterials science & engineering.

Instructions for use Title Application of apolipoprotein E-modified liposomal nanoparticles as a carrier for delivering DNA and nucleic acid in the brain

H. Harashima, Yusuke Sato, H. Akita, 2017 .

Development of a Microfluidic-Based Post-Treatment Process for Size-Controlled Lipid Nanoparticles and Application to siRNA Delivery.

M. Tokeshi, Masatoshi Maeki, A. Ishida, 2020, ACS applied materials & interfaces.

Evolution of drug delivery system from viewpoint of controlled intracellular trafficking and selective tissue targeting toward future nanomedicine

Takashi Nakamura, H. Harashima, Yusuke Sato, 2020, Journal of Controlled Release.

Maximizing the Oral Bioavailability of Poorly Water-Soluble Drugs Using Novel Oil-Like Materials in Lipid-Based Formulations.

M. Kataoka, S. Yamashita, H. Harashima, 2021, Molecular pharmaceutics.

Delivering mRNA to a human NK cell line, NK-92 cells, by lipid nanoparticles.

Takashi Nakamura, H. Harashima, Yusuke Sato, 2023, International journal of pharmaceutics.

Interval- and cycle-dependent combined effect of STING agonist loaded lipid nanoparticles and a PD-1 antibody.

Takashi Nakamura, H. Harashima, Yusuke Sato, 2022, International journal of pharmaceutics.

A strategy for synthesis of lipid nanoparticles using microfluidic devices with a mixer structure

N. Kaji, M. Tokeshi, Y. Baba, 2015 .

Topology of Surface Ligands on Liposomes: Characterization Based on the Terms, Incorporation Ratio, Surface Anchor Density, and Reaction Yield.

H. Harashima, Yusuke Sato, M. Hyodo, 2016, Biological & pharmaceutical bulletin.

Mixing lipids to manipulate the ionization status of lipid nanoparticles for specific tissue targeting

H. Harashima, Yusuke Sato, Nour Shobaki, 2018, International journal of nanomedicine.

Small-sized, stable lipid nanoparticle for the efficient delivery of siRNA to human immune cell lines

Takashi Nakamura, H. Harashima, Yusuke Sato, 2016, Scientific Reports.

Recent advances in the targeting of systemically administered non-viral gene delivery systems

I. Khalil, H. Harashima, Yusuke Sato, 2019, Expert opinion on drug delivery.

Novel PEGylated Lipid Nanoparticles Have a High Encapsulation Efficiency and Effectively Deliver MRTF-B siRNA in Conjunctival Fibroblasts

C. Yu-Wai-Man, H. Harashima, Yusuke Sato, 2021, Pharmaceutics.

Multifunctional envelope-type nano device for controlled intracellular trafficking and selective targeting in vivo.

Takashi Nakamura, H. Harashima, Yusuke Sato, 2014, Journal of controlled release : official journal of the Controlled Release Society.

Self-homing nanocarriers for mRNA delivery to the activated hepatic stellate cells in liver fibrosis.

H. Harashima, Yusuke Sato, M. Younis, 2022, Journal of controlled release : official journal of the Controlled Release Society.

Engineered ε-decalactone lipomers bypass the liver to selectively in vivo deliver mRNA to the lungs without targeting ligands.

T. Satoh, H. Harashima, Yusuke Sato, 2021, Materials horizons.

Relationship Between the Physicochemical Properties of Lipid Nanoparticles and the Quality of siRNA Delivery to Liver Cells.

H. Harashima, Yusuke Sato, H. Hatakeyama, 2016, Molecular therapy : the journal of the American Society of Gene Therapy.

RNAi-mediated gene knockdown and anti-angiogenic therapy of RCCs using a cyclic RGD-modified liposomal-siRNA system.

H. Harashima, Yusuke Sato, H. Akita, 2014, Journal of controlled release : official journal of the Controlled Release Society.

Reducing the Cytotoxicity of Lipid Nanoparticles Associated with a Fusogenic Cationic Lipid in a Natural Killer Cell Line by Introducing a Polycation-Based siRNA Core.

Takashi Nakamura, H. Harashima, Yusuke Sato, 2018, Molecular pharmaceutics.

pH-labile PEGylation of siRNA-loaded lipid nanoparticle improves active targeting and gene silencing activity in hepatocytes.

H. Harashima, Yusuke Sato, Kazuki Hashiba, 2017, Journal of controlled release : official journal of the Controlled Release Society.

Organic-Inorganic Hybrid Nanoparticles for Tracking the Same Cells Seamlessly at the Cellular, Tissue, and Whole Body Levels.

Koichiro Hayashi, W. Sakamoto, T. Yogo, 2017, ACS biomaterials science & engineering.

A new adjuvant delivery system

Takashi Nakamura, H. Harashima, Yusuke Sato, 2023 .

The RNA sensor RIG-I dually functions as an innate sensor and direct antiviral factor for hepatitis B virus.

C. Rice, A. Takaoka, M. Kohara, 2015, Immunity.

Cellular environment-responsive nanomaterials for use in gene and siRNA delivery: molecular design for biomembrane destabilization and intracellular collapse

H. Harashima, Hiroki Tanaka, Yusuke Sato, 2016, Expert opinion on drug delivery.

Elucidation of the physicochemical properties and potency of siRNA-loaded small-sized lipid nanoparticles for siRNA delivery.

N. Kaji, M. Tokeshi, Y. Baba, 2016, Journal of controlled release : official journal of the Controlled Release Society.

Reprogramming activated hepatic stellate cells by siRNA-loaded nanocarriers reverses liver fibrosis in mice.

H. Harashima, Yusuke Sato, M. Younis, 2023, Journal of controlled release : official journal of the Controlled Release Society.

Understanding the formation mechanism of lipid nanoparticles in microfluidic devices with chaotic micromixers

N. Kaji, M. Tokeshi, Y. Baba, 2017, PloS one.

Development of Polymer-Lipid Hybrid Nanoparticles for Large-Sized Plasmid DNA Transfection.

Masatoshi Maeki, Yusuke Sato, Y. Fujioka, 2023, ACS applied materials & interfaces.

Mixing lipids to manipulate the ionization status of lipid nanoparticles for specific tissue targeting

H. Harashima, Yusuke Sato, Nour Shobaki, 2018, International journal of nanomedicine.

Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanoma.

Takashi Nakamura, H. Harashima, Yusuke Sato, 2015, Journal of controlled release : official journal of the Controlled Release Society.

Harnessing Topology and Stereochemistry of Glycidylamine‐Derived Lipid Nanoparticles for in Vivo mRNA Delivery to Immune Cells in Spleen and Their Application for Cancer Vaccination

T. Satoh, Takashi Nakamura, H. Harashima, 2023, Advanced Functional Materials.

Application of apolipoprotein E-modified liposomal nanoparticles as a carrier for delivering DNA and nucleic acid in the brain

Yusuke Sato, H. Akita, H. Hatakeyama, 2014, International journal of nanomedicine.

A Multifunctional Envelope-Type Nano Device Containing a pH-Sensitive Cationic Lipid for Efficient Delivery of Short Interfering RNA to Hepatocytes In Vivo.

M. Kohara, H. Harashima, Yusuke Sato, 2016, Methods in molecular biology.

The impact of, and expectations for, lipid nanoparticle technology: From cellular targeting to organelle targeting.

Takashi Nakamura, Yusuke Sato, Hideyoshi Harashima, 2024, Journal of controlled release : official journal of the Controlled Release Society.

Vaccination with a combination of STING agonist-loaded lipid nanoparticles and CpG-ODNs protects against lung metastasis via the induction of CD11bhighCD27low memory-like NK cells

Takashi Nakamura, Yusuke Sato, Hideyoshi Harashima, 2024, Experimental hematology & oncology.

Impact of Lipid Tail Length on the Organ Selectivity of mRNA-Lipid Nanoparticles

Yusuke Sato, Kazuki Hashiba, Masamitsu Taguchi, 2024, Nano letters.