G. Lee

发表

Heparan sulfate proteoglycan synthesis in CHO DG44 and HEK293 cells

W. Heo, Sojeong Lee, M. Kim, 2016, Biotechnology and Bioprocess Engineering.

Bcl-2 overexpression in CHO cells improves polyethylenimine-mediated gene transfection

Sojeong Lee, G. Lee, 2013 .

Initial transcriptome and proteome analyses of low culture temperature-induced expression in CHO cells producing erythropoietin.

G. Lee, Young Hwan Kim, J. Baik, 2006, Biotechnology and bioengineering.

Ribosome profiling-guided depletion of an mRNA increases cell growth rate and protein secretion

N. Lewis, M. Andersen, Shangzhong Li, 2017, Scientific Reports.

Improving the secretory capacity of Chinese hamster ovary cells by ectopic expression of effector genes: Lessons learned and future directions.

H. Hansen, G. Lee, H. F. Kildegaard, 2017, Biotechnology advances.

Guidelines for the use and interpretation of assays formonitoring autophagy (3rd edition)

Sangeeta Khare, Xin Qi, Ying Wang, 2016 .

Use of NaCl prevents aggregation of recombinant COMP-angiopoietin-1 in Chinese hamster ovary cells.

Gyun Min Lee, Sung Kwan Yoon, G. Lee, 2009, Journal of biotechnology.

COMP-Ang1: a designed angiopoietin-1 variant with nonleaky angiogenic activity.

Sung Hyun Kim, Chung-Hyun Cho, Gyun Min Lee, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Monitoring of autophagy in Chinese hamster ovary cells using flow cytometry.

G. Lee, Jae Seong Lee, 2012, Methods.

One-step generation of triple knockout CHO cell lines using CRISPR/Cas9 and fluorescent enrichment.

Stefan Kol, Gyun Min Lee, Lasse Ebdrup Pedersen, 2015, Biotechnology journal.

Current state and perspectives on erythropoietin production

G. Lee, T. Ha, Jae Seong Lee, 2012, Applied Microbiology and Biotechnology.

The molecular weight and concentration of dextran sulfate affect cell growth and antibody production in CHO cell cultures

J. Woo, G. Lee, Jin Hyoung Park, 2016 .

Assessment of cell engineering strategies for improved therapeutic protein production in CHO cells

Yeon‐Gu Kim, G. Lee, C. Mohan, 2008, Biotechnology journal.

Flow cytometric analysis of antibody producing cells using double immunofluorescent staining

J. H. Kim, G. Lee, Hee-Gu Lee, 1996 .

Effect of fixation temperature on flow cytometric measurement of intracellular antibody content of hybridomas during batch culture

B. Palsson, G. Lee, A. Chuck, 1993 .

Effect of mitochondrial and ER-targeted Bcl-2 overexpression on apoptosis in recombinant Chinese hamster ovary cells treated with sodium butyrate

Hongweon Lee, Yeon‐Gu Kim, G. Lee, 2012 .

Effect of Bcl-xL overexpression on erythropoietin production in recombinant Chinese hamster ovary cells treated with dimethyl sulfoxide

Hongweon Lee, Yeon‐Gu Kim, G. Lee, 2011 .

Hyperosmotic pressure enhances immunoglobulin transcription rates and secretion rates of KR12H‐2 transfectoma

G. Lee, Moon-Sue Lee, 2000, Biotechnology and bioengineering.

Effects of Cloned Gene Dosage on the Response of Recombinant CHO Cells to Hyperosmotic Pressure in Regard to Cell Growth and Antibody Production

G. Lee, Moon-Sue Lee, J. S. Ryu, 2001, Biotechnology progress.

Effect of inducible co‐overexpression of protein disulfide isomerase and endoplasmic reticulum oxidoreductase on the specific antibody productivity of recombinant Chinese hamster ovary cells

G. Lee, C. Mohan, 2010, Biotechnology and bioengineering.

Effect of glucose feeding on the glycosylation quality of antibody produced by a human cell line, F2N78, in fed-batch culture

G. Lee, J. Seo, B. Min, 2014, Applied Microbiology and Biotechnology.

Proteomic analysis of host cell protein dynamics in the supernatant of Fc‐fusion protein‐producing CHO DG44 and DUKX‐B11 cell lines in batch and fed‐batch cultures

Jong Hwa Jin, G. Lee, H. An, 2017, Biotechnology and bioengineering.

Alleviation of proteolytic degradation of recombinant human bone morphogenetic protein-4 by repeated batch culture of Chinese hamster ovary cells

Ju-woong Jang, G. Lee, C. Kim, 2016 .

Selection strategies for the establishment of recombinant Chinese hamster ovary cell line with dihydrofolate reductase-mediated gene amplification

G. Lee, J. Baik, S. Jun, 2005, Applied Microbiology and Biotechnology.

Glutamine substitution: the role it can play to enhance therapeutic protein production

G. Lee, T. Ha, 2015 .

Controlling medium osmolality improves the expansion of human articular chondrocytes in serum-free media.

B. Min, G. Lee, Kang-Il Kim, 2010, Tissue engineering. Part C, Methods.

Overexpression of PACEsol improves BMP-7 processing in recombinant CHO cells.

Ju-woong Jang, G. Lee, Jae Seong Lee, 2013, Journal of biotechnology.

Enhanced specific antibody productivity of calcium alginate-entrapped hybridoma is cell line-specific

B. Palsson, G. Lee, Sang Jick Kim, 2004, Cytotechnology.

EFFECT OF HYPOOSMOTIC STRESS ON HYBRIDOMA CELL GROWTH AND ANTIBODY PRODUCTION

G. Lee, J. S. Ryu, 1997 .

Influence of hyperosmolar basal media on hybridoma cell growth and antibody production

Gyun Min Lee, G. Lee, J. S. Ryu, 1997 .

Biphasic culture strategy based on hyperosmotic pressure for improved humanized antibody production in Chinese hamster ovary cell culture

G. Lee, Y. H. Sung, Yun Hee Sung, 2002, In Vitro Cellular & Developmental Biology - Animal.

Production of monoclonal antibody using free and immobilized hybridoma cells.

G. Lee, 1990 .

Inhibition of sodium butyrate-induced apoptosis in recombinant Chinese hamster ovary cells by constitutively expressing antisense RNA of caspase-3.

G. Lee, N. Kim, 2002, Biotechnology and bioengineering.

Differential in‐gel electrophoresis (DIGE) analysis of CHO cells under hyperosmotic pressure: Osmoprotective effect of glycine betaine addition

Yeon‐Gu Kim, G. Lee, Jee Yon Kim, 2012, Biotechnology and bioengineering.

Bcl-x(L) overexpression delays the onset of autophagy and apoptosis in hyperosmotic recombinant Chinese hamster ovary cell cultures.

Yeon‐Gu Kim, G. Lee, T. Ha, 2011, Journal of biotechnology.

Differential protein expression in human articular chondrocytes expanded in serum-free media of different medium osmolalities by DIGE.

B. Min, G. Lee, Kang-Il Kim, 2010, Journal of proteome research.

Comprehensive Analysis of Genomic Safe Harbors as Target Sites for Stable Expression of the Heterologous Gene in HEK293 Cells.

S. H. Kim, G. Lee, S. W. Shin, 2020, ACS synthetic biology.

Characterization and expression of proprotein convertases in CHO cells: Efficient proteolytic maturation of human bone morphogenetic protein‐7

Ju-woong Jang, G. Lee, C. Kim, 2015, Biotechnology and bioengineering.

Efficient differentiation of human pluripotent stem cells into mesenchymal stem cells by modulating intracellular signaling pathways in a feeder/serum-free system.

G. Lee, Yong-Mahn Han, Q. Trinh, 2012, Stem cells and development.

Development of a serum-free medium for dihydrofolate reductase-deficient chinese hamster ovary cells (DG44) using a statistical design: Beneficial effect of weaning of cells

Gyun Min Lee, G. Lee, E. J. Kim, 1999, In Vitro Cellular & Developmental Biology - Animal.

Effect of sodium butyrate on the assembly, charge variants, and galactosylation of antibody produced in recombinant Chinese hamster ovary cells

G. Lee, J. K. Hong, Sang Min Lee, 2014, Applied Microbiology and Biotechnology.

Improving recombinant bone morphogenetic protein-4 (BMP-4) production by autoregulatory feedback loop removal using BMP receptor-knockout CHO cell lines.

G. Lee, C. Kim, 2019, Metabolic engineering.

Improving the production of recombinant human bone morphogenetic protein‐4 in Chinese hamster ovary cell cultures by inhibition of undesirable endocytosis

Ju-woong Jang, G. Lee, C. Kim, 2018, Biotechnology and bioengineering.

Expression and purification of recombinant human angiopoietin-2 produced in Chinese hamster ovary cells.

G. Koh, G. Lee, H. Hong, 2005, Protein expression and purification.

Down-regulation of cold-inducible RNA-binding protein does not improve hypothermic growth of Chinese hamster ovary cells producing erythropoietin.

G. Lee, S. Yoon, J. K. Hong, 2007, Metabolic engineering.

Justification of continuous packed-bed reactor for retroviral vector production from amphotropic ΨCRIP murine producer cell

G. Lee, Byung-Gee Kim, Seunghyun Kang, 2000, Cytotechnology.

Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2

H. Augustin, K. Alitalo, N. Ekman, 2005, The Journal of cell biology.

Artificial Transcription Factors Increase Production of Recombinant Antibodies in Chinese Hamster Ovary Cells

W. Seol, G. Lee, Jin-Soo Kim, 2005, Biotechnology Letters.

Novel Glycosylated VEGF Decoy Receptor Fusion Protein, VEGF-Grab, Efficiently Suppresses Tumor Angiogenesis and Progression

S. C. Kim, Ho Min Kim, G. Koh, 2014, Molecular Cancer Therapeutics.

Development of an in vitro screening system for synthetic signal peptide in mammalian cell-based protein production

G. Lee, Yeon-Gu Kim, Jong-Ho Park, 2022, Applied Microbiology and Biotechnology.

Cell Culture conditions determine the enhancement of specific monoclonal antibody productivity of calcium alginate‐entrapped S3H5/γ2bA2 hybridoma cells

B. Palsson, G. Lee, A. Chuck, 1993, Biotechnology and bioengineering.

High Productivity of t-PA in CHO Cells Using Hypoxia Response Element

G. Lee, Hong-Jin Kim, Ik-Hwan Kim, 2006 .

Double Anti-angiogenic and Anti-inflammatory Protein Valpha Targeting VEGF-A and TNF-α in Retinopathy and Psoriasis*

S. C. Kim, G. Koh, G. Lee, 2011, The Journal of Biological Chemistry.

Effect of constitutively active ras overexpression on cell growth in recombinant chinese hamster ovary cells

Hongweon Lee, G. Lee, Eun Gyo Lee, 2011, Biotechnology progress.

Limitations to the comparative proteomic analysis of thrombopoietin producing Chinese hamster ovary cells treated with sodium butyrate.

G. Lee, Young Hwan Kim, J. Baik, 2008, Journal of biotechnology.

Simple and Robust N-Glycan Analysis Based on Improved 2-Aminobenzoic Acid Labeling for Recombinant Therapeutic Glycoproteins.

S. Kim, G. Lee, Young Sam Park, 2018, Journal of pharmaceutical sciences.

Anti-Apoptosis Engineering for Improved Protein Production from CHO Cells.

G. Lee, Eric Baek, S. Noh, 2017, Methods in molecular biology.

Reduction of ammonia and lactate through the coupling of glutamine synthetase selection and downregulation of lactate dehydrogenase-A in CHO cells

G. Lee, Jin Hyoung Park, Jong Won Kim, 2017, Applied Microbiology and Biotechnology.

Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion

Jahir M. Gutierrez, B. Palsson, N. Lewis, 2018, Nature Communications.

Immobilization of Zymomonas mobilis and amyloglucosidase for ethanol production from sago starch

S. Rhee, G. Lee, C. H. Kim, 1988 .

Analysis of Golgi pH in Chinese hamster ovary cells using ratiometric pH‐sensitive fluorescent proteins

W. Heo, Jong Hyun Lee, G. Lee, 2019, Biotechnology and bioengineering.

Comprehensive Physicochemical and Biological Characterization of the Proposed Biosimilar Darbepoetin Alfa, LBDE, and Its Originator Darbepoetin Alfa, NESP®

Mideum Song, G. Lee, Saem Jung, 2018, BioDrugs.

Using Titer and Titer Normalized to Confluence Are Complementary Strategies for Obtaining Chinese Hamster Ovary Cell Lines with High Volumetric Productivity of Etanercept.

M. Andersen, N. Borth, H. Hansen, 2018, Biotechnology journal.

Versatile microscale screening platform for improving recombinant protein productivity in Chinese hamster ovary cells

M. Andersen, Johan Rockberg, Magnus Lundqvist, 2015, Scientific Reports.

Characterization of Humanized Antibody produced by Apoptosis-Resistant CHO Cells under Sodium Butyrate-Induced Condition

G. Lee, Jung Hoe Kim, Sung Hyun Kim, 2000 .

Effect of Akt overexpression on programmed cell death in antibody-producing Chinese hamster ovary cells.

G. Lee, S. Hwang, 2009, Journal of biotechnology.

Hyperosmotic stress induces autophagy and apoptosis in recombinant Chinese hamster ovary cell culture.

G. Lee, Y. Han, Jee Yon Kim, 2010, Biotechnology and bioengineering.

Angiopoietin-2 Exocytosis Is Stimulated by Sphingosine-1-Phosphate in Human Blood and Lymphatic Endothelial Cells

S. K. Park, G. Lee, Cholsoon Jang, 2009, Arteriosclerosis, thrombosis, and vascular biology.

Effect of anchorage dependency on growth rate and monoclonal antibody production of hybridoma cells

B. Palsson, G. Lee, T. Huard, 1988, Biotechnology Letters.

A proteomic approach for identifying cellular proteins interacting with erythropoietin in recombinant Chinese hamster ovary cells

G. Lee, Young Hwan Kim, J. Baik, 2009, Biotechnology progress.

Chemical inhibition of autophagy: Examining its potential to increase the specific productivity of recombinant CHO cell lines

M. Kim, G. Lee, Jae Seong Lee, 2016, Biotechnology and bioengineering.

Effect of sodium butyrate on autophagy and apoptosis in Chinese hamster ovary cells

G. Lee, Jae Seong Lee, 2012, Biotechnology progress.

A Chinese hamster transcription start site atlas that enables targeted editing of CHO cells

C. Glass, Isaac Shamie, N. Lewis, 2020, bioRxiv.

Functional expression of human pyruvate carboxylase for reduced lactic acid formation of Chinese hamster ovary cells (DG44)

G. Lee, Sung Hyun Kim, 2007, Applied Microbiology and Biotechnology.

Influence of culture passages on growth kinetics and adenovirus vector production for gene therapy in monolayer and suspension cultures of HEK 293 cells

G. Lee, E. Jo, Sung Hyun Kim, 2004, Applied Microbiology and Biotechnology.

Amplification of EBNA-1 through a single-plasmid vector-based gene amplification system in HEK293 cells as an efficient transient gene expression system

Eunju Lee, Joo-Hyoung Lee, Sun‐Hye Park, 2020, Applied Microbiology and Biotechnology.

Effect of lithium chloride on the production and sialylation of Fc-fusion protein in Chinese hamster ovary cell culture

G. Lee, T. Ha, Yeon-Gu Kim, 2014, Applied Microbiology and Biotechnology.

Comprehensive characterization of dihydrofolate reductase‐mediated gene amplification for the establishment of recombinant human embryonic kidney 293 cells producing monoclonal antibodies

G. Lee, Sang Yoon Lee, M. Baek, 2020, Biotechnology journal.

Glyco-engineered CHO cell lines producing alpha-1-antitrypsin and C1 esterase inhibitor with fully humanized N-glycosylation profiles.

M. Andersen, Johnny Arnsdorf, B. Voldborg, 2019, Metabolic engineering.

Untangling the mechanism of 3‐methyladenine in enhancing the specific productivity: Transcriptome analysis of recombinant Chinese hamster ovary cells treated with 3‐methyladenine

G. Lee, Jae Seong Lee, Eric Baek, 2018, Biotechnology and bioengineering.

Effect of XIAP overexpression on sodium butyrate-induced apoptosis in recombinant Chinese hamster ovary cells producing erythropoietin.

G. Lee, Jee Yon Kim, Yeon-Gu Kim, 2009, Journal of biotechnology.

A role of GADD153 in ER stress-induced apoptosis in recombinant Chinese hamster ovary cells

G. Lee, C. Mohan, M. Sathyamurthy, 2012, Biotechnology and Bioprocess Engineering.

Baicalein Reduces Oxidative Stress in CHO Cell Cultures and Improves Recombinant Antibody Productivity.

G. Lee, S. Kol, T. Ha, 2018, Biotechnology journal.

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

Mark R. Marten, Erinna F. Lee, Dana L. Miller, 2021, Autophagy.

Long-Term and Sustained COMP-Ang1 Induces Long-Lasting Vascular Enlargement and Enhanced Blood Flow

D. McDonald, N. Mochizuki, B. Jeon, 2005, Circulation research.

Double-antiangiogenic protein DAAP targeting vascular endothelial growth factor A and angiopoietins attenuates collagen-induced arthritis

K. Jang, G. Koh, G. Lee, 2013, Arthritis Research & Therapy.

Effect of culture pH on recombinant antibody production by a new human cell line, F2N78, grown in suspension at 33.0 °C and 37.0 °C

G. Lee, J. Seo, Y. Kim, 2013, Applied Microbiology and Biotechnology.

Combinatorial engineering of ldh-a and bcl-2 for reducing lactate production and improving cell growth in dihydrofolate reductase-deficient Chinese hamster ovary cells

G. Lee, Min Kyoung Jeon, D. Yu, 2011, Applied Microbiology and Biotechnology.

Awakening dormant glycosyltransferases in CHO cells with CRISPRa

Isaac Shamie, N. Lewis, Shangzhong Li, 2020, Biotechnology and bioengineering.

Selective endocytosis of recombinant human BMPs through cell surface heparan sulfate proteoglycans in CHO cells: BMP-2 and BMP-7

Ju-woong Jang, M. Kim, G. Lee, 2021, Scientific Reports.

Co-amplification of EBNA-1 and PyLT through dhfr-mediated gene amplification for improving foreign protein production in transient gene expression in CHO cells

Sun-Hong Kim, Joo-Hyoung Lee, Sun‐Hye Park, 2018, Applied Microbiology and Biotechnology.

Accelerated homology-directed targeted integration of transgenes in Chinese hamster ovary cells via CRISPR/Cas9 and fluorescent enrichment.

G. Lee, L. Pedersen, H. F. Kildegaard, 2016, Biotechnology and bioengineering.

Purification of TNFR-Fc produced in recombinant CHO cells: Characterization of product-related impurities

G. Lee, K. Min, 2015 .

Effect of sodium butyrate on the production, heterogeneity and biological activity of human thrombopoietin by recombinant Chinese hamster ovary cells.

G. Lee, Y. H. Sung, Y. Song, 2004, Journal of biotechnology.

Gadd45-induced cell cycle G2/M arrest for improved transient gene expression in Chinese hamster ovary cells

G. Lee, Y. Kim, Won Hee Kim, 2014, Biotechnology and Bioprocess Engineering.

Anti‐cell death engineering of CHO cells: Co‐overexpression of Bcl‐2 for apoptosis inhibition, Beclin‐1 for autophagy induction

G. Lee, T. Ha, Jae Seong Lee, 2013, Biotechnology and bioengineering.

A simple analysis system for the estimation of recombination efficiency using fluorescence-activated cell sorting.

G. Lee, Min Soo Kim, Won Hee Kim, 2007, Journal of biotechnology.

Differential induction of autophagy in caspase-3/7 down-regulating and Bcl-2 overexpressing recombinant CHO cells subjected to sodium butyrate treatment.

G. Lee, Jae Seong Lee, C. Kim, 2012, Journal of biotechnology.

Limitations to the Development of Humanized Antibody Producing Chinese Hamster Ovary Cells Using Glutamine Synthetase‐Mediated Gene Amplification

G. Lee, H. Hong, S. Jun, 2006, Biotechnology progress.

Characterization of site-specific recombination mediated by Cre recombinase during the development of erythropoietin producing CHO cell lines

G. Lee, Min Soo Kim, Won Hee Kim, 2008 .

Flow Cytometric Application of Helper Adenovirus (HAd) Containing GFP Gene Flanked by Two Parallel loxP Sites to Evaluation of 293 Cre‐Complementing Cell Line and Monitoring of HAd in Gutless Ad Production

G. Lee, Su-Jeong Hwang, M. T. Park, 2004, Biotechnology progress.

Improving bone morphogenetic protein (BMP) production in CHO cells through understanding of BMP synthesis, signaling and endocytosis.

G. Lee, Kyungsoo Kim, Mi Gyeom Kim, 2022, Biotechnology advances.

Blockage of undesirable endocytosis of recombinant human growth/differentiation factor‐5 in Chinese hamster ovary cell cultures requires heparin analogs with specific chain lengths

G. Lee, Mi Gyeom Kim, 2021, Biotechnology journal.

Effect of Ca2+ and Mg2+ concentration in culture medium on the activation of recombinant factor IX produced in Chinese hamster ovary cells.

G. Lee, Yeup Yoon, Jung-Seob Kim, 2009, Journal of biotechnology.

Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2

H. Augustin, K. Alitalo, N. Ekman, 2005, The Journal of cell biology.

Continuous ethanol production from sago starch using immobilized amyloglucosidase and Zymomonas mobilis

G. Lee, S. Rhee, C. Kim, 1987 .

Effect of low culture temperature on specific productivity, transcription level, and heterogeneity of erythropoietin in Chinese hamster ovary cells.

Gyun Min Lee, Sung Kwan Yoon, G. Lee, 2003, Biotechnology and bioengineering.

Enhanced Human Thrombopoietin Production by Sodium Butyrate Addition to Serum‐Free Suspension Culture of Bcl‐2‐Overexpressing CHO Cells

G. Lee, Y. H. Sung, Yun Hee Sung, 2008, Biotechnology progress.

Nutrient deprivation induces autophagy as well as apoptosis in Chinese hamster ovary cell culture

G. Lee, S. Hwang, 2008, Biotechnology and bioengineering.

Biphasic culture strategy for enhancing volumetric erythropoietin productivity of Chinese hamster ovary cells

G. Lee, S. Yoon, Sung Hyun Kim, 2006 .

Electrospun chitosan/poly(vinyl alcohol) reinforced with CaCO3 nanoparticles with enhanced mechanical properties and biocompatibility for cartilage tissue engineering

Seung-Bin Park, G. Lee, N. S. Sambudi, 2015 .

Osmolarity Effects, Chinese Hamster Ovary Cell Culture

G. Lee, J. Koo, 2010 .

Proteome Analysis of Antibody‐Expressing CHO Cells in Response to Hyperosmotic Pressure

Young Hwan Kim, Gyun Min Lee, G. Lee, 2003, Biotechnology progress.

Response of recombinant Chinese hamster ovary cells to hyperosmotic pressure: effect of Bcl-2 overexpression.

Gyun Min Lee, G. Lee, No Soo Kim, 2002, Journal of biotechnology.

Osmoprotective Effect of Glycine Betaine on Thrombopoietin Production in Hyperosmotic Chinese Hamster Ovary Cell Culture: Clonal Variations

G. Lee, J. S. Ryu, J Y Chung, 2000, Biotechnology progress.

Effect of lithium chloride on the production and sialylation of Fc-fusion protein in Chinese hamster ovary cell culture

G. Lee, T. Ha, Yeon-Gu Kim, 2014, Applied Microbiology and Biotechnology.

The enhancement of recombinant protein production by polymer nanospheres in cell suspension culture.

J. Ryu, G. Lee, Byung‐Soo Kim, 2005, Biomaterials.

Autophagy and its implication in Chinese hamster ovary cell culture

G. Lee, Jae Seong Lee, Eric Baek, 2013, Biotechnology Letters.

Cell Line Development for Therapeutic Protein Production

G. Lee, Seunghyeon Shin, S. Noh, 2019, Cell Culture Engineering.

Effect of culture pH on erythropoietin production by Chinese hamster ovary cells grown in suspension at 32.5 and 37.0 degrees C.

Gyun Min Lee, Sung Kwan Yoon, G. Lee, 2005, Biotechnology and bioengineering.

Autophagy and apoptosis of recombinant Chinese hamster ovary cells during fed‐batch culture: Effect of nutrient supplementation

G. Lee, T. Ha, Jae Seong Lee, 2011, Biotechnology and bioengineering.

Forskolin Increases cAMP Levels and Enhances Recombinant Antibody Production in CHO Cell Cultures

G. Lee, C. Yoon, Dongil Kim, 2020 .

Effect of doxycycline‐regulated protein disulfide isomerase expression on the specific productivity of recombinant CHO cells: Thrombopoietin and antibody

G. Lee, Soon-Hye Park, C. Mohan, 2007, Biotechnology and bioengineering.

Comparison of cell disruption methods for determining β-galactosidase activity expressed in animal cells

G. Lee, Jung Hoe Kim, J. Shin, 1994 .

Double antiangiogenic protein, DAAP, targeting VEGF-A and angiopoietins in tumor angiogenesis, metastasis, and vascular leakage.

D. Nam, A. Nagy, B. Jeon, 2010, Cancer cell.

Biological characterization of angiopoietin‐3 and angiopoietin‐4

Ju-Hyun Kim, G. Koh, G. Lee, 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Multi-copy targeted integration for accelerated development of high-producing CHO cells.

L. Nielsen, G. Lee, L. M. Grav, 2020, ACS synthetic biology.

An optimized genome-wide, virus-free CRISPR screen for mammalian cells

N. Lewis, Shangzhong Li, Hooman Hefzi, 2021, Cell reports methods.

Using targeted genome integration for virus-free genome-wide mammalian CRISPR screen

N. Lewis, Shangzhong Li, Hooman Hefzi, 2020, bioRxiv.

Temperature significantly affects retroviral vector production and deactivation rates, and thereby determines retroviral titers

B. Palsson, G. Lee, S. Jun, 1998 .

Effect of serum concentration on retroviral vector production from the amphotropic ψCRIP murine producer cells

Jong Hyun Choi, G. Lee, S. Jun, 1997 .

Influence of down-regulation of caspase-3 by siRNAs on sodium-butyrate-induced apoptotic cell death of Chinese hamster ovary cells producing thrombopoietin.

G. Lee, Su-Jeong Hwang, Y. H. Sung, 2005, Metabolic engineering.

Rapid titer assay of adenovirus containing green fluorescent protein gene using flow cytometric analysis

G. Lee, Min Tae Park, 2000 .

Recombinase-mediated cassette exchange-based screening of a CRISPR/Cas9 library for enhanced recombinant protein production in human embryonic kidney cells: Improving resistance to hyperosmotic stress.

G. Lee, Jae Seong Lee, Seunghyeon Shin, 2022, Metabolic engineering.

Improving the secretory capacity of CHO producer cells: The effect of controlled Blimp1 expression, a master transcription factor for plasma cells.

S. H. Kim, G. Lee, Jae Seong Lee, 2021, Metabolic engineering.

A DIGE approach for the assessment of differential expression of the CHO proteome under sodium butyrate addition: Effect of Bcl‐xL overexpression

G. Lee, J. Baik, 2010, Biotechnology and bioengineering.

Down-regulation of lactate dehydrogenase-A by siRNAs for reduced lactic acid formation of Chinese hamster ovary cells producing thrombopoietin

Sung Hyun Kim, Gyun Min Lee, G. Lee, 2007, Applied Microbiology and Biotechnology.

CHO cells in biotechnology for production of recombinant proteins: current state and further potential

Gyun Min Lee, G. Lee, Yeon-Gu Kim, 2012, Applied Microbiology and Biotechnology.

Effects of culture temperature and pH on flag-tagged COMP angiopoietin-1 (FCA1) production from recombinant CHO cells: FCA1 aggregation

Gyun Min Lee, Sung Kwan Yoon, Gou Young Koh, 2011, Applied Microbiology and Biotechnology.

Designed angiopoietin-1 variant, COMP-Ang1, protects against radiation-induced endothelial cell apoptosis.

R. Kammerer, G. Koh, S. K. Park, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Cell Engineering for Therapeutic Protein Production

G. Lee, Jin Hyoung Park, Eric Baek, 2015 .

Expansion of Human Bone Marrow Progenitor Cells in a High Cell Density Continuous Perfusion System

Bernhard O. Palsson, Se-Hwan Paek, B. Palsson, 1993, Bio/Technology.

Key Determinants in the Occurrence of Clonal Variation in Humanized Antibody Expression of CHO Cells during Dihydrofolate Reductase Mediated Gene Amplification

G. Lee, G. M. Lee, N. Kim, 2001, Biotechnology progress.

Development of a serum-free medium for in vitro expansion of human cytotoxic T lymphocytes using a statistical design

Gyun Min Lee, G. Lee, Jong-Baeck Lim, 2010, BMC biotechnology.

Glutamine synthetase gene knockout-human embryonic kidney 293E cells for stable production of monoclonal antibodies.

G. Lee, Sang Yoon Lee, D. Yu, 2018, Biotechnology and bioengineering.

Investigation of relationship between EBNA-1 expression level and specific foreign protein productivity in transient gene expression of HEK293 cells

Joo-Hyoung Lee, Sun‐Hye Park, G. Lee, 2017 .

Differential expression of microRNAs in recombinant Chinese hamster ovary cells treated with sodium butyrate using digital RNA counting.

Joo-Hyoung Lee, Sun‐Hye Park, G. Lee, 2018, Journal of biotechnology.

Limitations to the development of recombinant human embryonic kidney 293E cells using glutamine synthetase-mediated gene amplification: Methionine sulfoximine resistance.

G. Lee, S. Noh, D. Yu, 2016, Journal of biotechnology.

Development of apoptosis-resistant CHO cell line expressing PyLT for the enhancement of transient antibody production

G. Lee, Min Soo Kim, Yeon-Gu Kim, 2012 .

Bcl‐xL overexpression does not enhance specific erythropoietin productivity of recombinant CHO cells grown at 33°C and 37°C

G. Lee, Yeon-Gu Kim, 2009, Biotechnology progress.

Enhanced interferon‐β production by CHO cells through elevated osmolality and reduced culture temperature

G. Lee, Tai Young Koo, Y. Han, 2009, Biotechnology progress.

Mitigating Clonal Variation in Recombinant Mammalian Cell Lines.

N. Lewis, G. Lee, H. F. Kildegaard, 2019, Trends in biotechnology.

Factors affecting the quality of therapeutic proteins in recombinant Chinese hamster ovary cell culture.

G. Lee, T. Ha, L. M. Grav, 2021, Biotechnology advances.

Effect of Simultaneous Application of Stressful Culture Conditions on Specific Productivity and Heterogeneity of Erythropoietin in Chinese Hamster Ovary Cells

G. Lee, S. Yoon, J. K. Hong, 2004, Biotechnology progress.

Valeric acid induces cell cycle arrest at G1 phase in CHO cell cultures and improves recombinant antibody productivity.

Gyun Min Lee, J. Woo, G. Lee, 2016, Biotechnology journal.

Platform Technology for Therapeutic Protein Production

G. Lee, T. Ha, Jae Seong Lee, 2019, Cell Culture Engineering.

Rapid selection of single cells with high antibody production rates by microwell array.

Hak-Sung Kim, G. Lee, Wanjung Kim, 2011, Journal of biotechnology.

Effect of Low Culture Temperature on Specific Productivity and Transcription Level of Anti‐4–1BB Antibody in Recombinant Chinese Hamster Ovary Cells

Sung Hyun Kim, Gyun Min Lee, Sung Kwan Yoon, 2008, Biotechnology progress.

Reduced apoptosis in Chinese hamster ovary cells via optimized CRISPR interference.

N. C. Yeo, N. Lewis, Shangzhong Li, 2019, Biotechnology and bioengineering.

Small molecule epigenetic modulators for enhancing recombinant antibody production in CHO cell cultures

G. Lee, C. Yoon, Dongil Kim, 2021, Biotechnology and bioengineering.

Effect of calcium chloride treatment on hybridoma cell viability and growth

B. Palsson, G. Lee, Jung Hoe Kim, 1992, Biotechnology Letters.

Current state and perspectives on erythropoietin production

G. Lee, T. Ha, Jae Seong Lee, 2012, Applied Microbiology and Biotechnology.

Effect of pyridine on the fatty acid composition of Pimelobacter sp.

S. Rhee, G. Lee, sung-taik lee, 1996 .

Stability of transfectomas producing chimeric antibody against the pre‐S2 surface antigen of hepatitis B virus during a long‐term culture

G. Lee, H. Hong, S. Bae, 1995, Biotechnology and bioengineering.

Effect of sodium butyrate on the assembly, charge variants, and galactosylation of antibody produced in recombinant Chinese hamster ovary cells

G. Lee, J. K. Hong, Sang Min Lee, 2014, Applied Microbiology and Biotechnology.

Effect of glucose feeding on the glycosylation quality of antibody produced by a human cell line, F2N78, in fed-batch culture

G. Lee, J. Seo, B. Min, 2014, Applied Microbiology and Biotechnology.

Effect of hypoosmotic pressure on cell growth and antibody production in recombinant Chinese hamster ovary cell culture

G. Lee, Moon-Sue Lee, 2001, Cytotechnology.

Rapamycin treatment inhibits CHO cell death in a serum‐free suspension culture by autophagy induction

G. Lee, Jae Seong Lee, 2012, Biotechnology and bioengineering.

Enhancing CHO cell productivity through a dual selection system using Aspg and Gs in glutamine free medium

L. Nielsen, N. Lewis, Hooman Hefzi, 2022, Biotechnology and bioengineering.

Comprehensive characterization of glutamine synthetase-mediated selection for the establishment of recombinant CHO cells producing monoclonal antibodies

G. Lee, Seunghyeon Shin, S. Noh, 2018, Scientific Reports.

Growth factor withdrawal in combination with sodium butyrate addition extends culture longevity and enhances antibody production in CHO cells.

G. Lee, S. Yoon, J. K. Hong, 2011, Journal of biotechnology.

Enhancing Effect of Low Culture Temperature on Specific Antibody Productivity of Recombinant Chinese Hamster Ovary Cells: Clonal Variation

Gyun Min Lee, Sung Kwan Yoon, G. Lee, 2004, Biotechnology progress.

Effect of doxycycline‐regulated calnexin and calreticulin expression on specific thrombopoietin productivity of recombinant chinese hamster ovary cells

G. Lee, S. Hwang, S. Lim, 2004, Biotechnology and bioengineering.

Effect of Doxycycline‐Regulated ERp57 Expression on Specific Thrombopoietin Productivity of Recombinant CHO Cells

G. Lee, S. Hwang, J. Chung, 2003, Biotechnology progress.

Oligomerization and Multimerization Are Critical for Angiopoietin-1 to Bind and Phosphorylate Tie2*

M. Steinmetz, R. Kammerer, B. Maco, 2005, Journal of Biological Chemistry.

CRISPR/Cas9-Multiplexed Editing of Chinese Hamster Ovary B4Gal-T1, 2, 3, and 4 Tailors N-Glycan Profiles of Therapeutics and Secreted Host Cell Proteins.

M. Andersen, G. Lee, S. Kol, 2018, Biotechnology journal.

Targeted Gene Deletion Using DNA-Free RNA-Guided Cas9 Nuclease Accelerates Adaptation of CHO Cells to Suspension Culture.

Byung-Kwan Cho, Namil Lee, Gyun Min Lee, 2016, ACS synthetic biology.

Calnexin overexpression sensitizes recombinant CHO cells to apoptosis induced by sodium butyrate treatment

G. Lee, C. Mohan, 2008, Cell Stress and Chaperones.

Streamlined Human Cell-Based Recombinase-Mediated Cassette Exchange Platform Enables Multigene Expression for the Production of Therapeutic Proteins.

S. H. Kim, G. Lee, Jae Seong Lee, 2021, ACS synthetic biology.

Systematic Evaluation of Site-Specific Recombinant Gene Expression for Programmable Mammalian Cell Engineering.

N. Lewis, M. Andersen, Hooman Hefzi, 2019, ACS synthetic biology.

Minimizing Clonal Variation during Mammalian Cell Line Engineering for Improved Systems Biology Data Generation.

Nathan E Lewis, Gyun Min Lee, Lars Keld Nielsen, 2018, ACS Synthetic Biology.

Use of Flp-mediated cassette exchange in the development of a CHO cell line stably producing erythropoietin.

G. Lee, Min Soo Kim, 2008, Journal of microbiology and biotechnology.

Bip inducer X: an ER stress inhibitor for enhancing recombinant antibody production in CHO cell culture.

G. Lee, T. Ha, H. F. Kildegaard, 2019, Biotechnology journal.

Combinatorial treatment with lithium chloride enhances recombinant antibody production in transiently transfected CHO and HEK293E cells

G. Lee, T. Ha, C. Kim, 2016, Biotechnology and Bioprocess Engineering.

Effect of culture pH on recombinant antibody production by a new human cell line, F2N78, grown in suspension at 33.0 °C and 37.0 °C

G. Lee, J. Seo, Jong-Moon Cho, 2013, Applied Microbiology and Biotechnology.

Enhanced cell growth, production, and mAb quality produced in Chinese hamster ovary-K1 cells by supplementing polyamine in the media

W. You, G. Lee, J. Baik, 2023, Applied Microbiology and Biotechnology.

A metabolic CRISPR-Cas9 screen in Chinese hamster ovary cells identifies glutamine-sensitive genes

David E. Ruckerbauer, N. Lewis, N. Borth, 2020, bioRxiv.

Biotransformation of rifamycin B to rifamycin S using immobilised whole cells of Humicola spp. in a fluidised bed reactor

C. Choi, G. Lee, M. Han, 1985 .

Effect of chemical chaperone addition on production and aggregation of recombinant flag‐tagged COMP‐angiopoietin 1 in chinese hamster ovary cells

G. Lee, S. Yoon, Su-Jeong Hwang, 2011, Biotechnology progress.

Amplification of EBNA-1 through a single-plasmid vector-based gene amplification system in HEK293 cells as an efficient transient gene expression system

G. Lee, Seunghyeon Shin, Yeon-Gu Kim, 2020, Applied Microbiology and Biotechnology.

Development of recombinant Chinese hamster ovary cell lines for therapeutic protein production

Gyun Min Lee, G. Lee, Soo Min Noh, 2013 .

Expression and purification of recombinant human Angiopoietin-1 produced in Chinese hamster ovary cells

G. Koh, G. Lee, Hak-Zoo Kim, 2007, In Vitro Cellular & Developmental Biology - Animal.

Multiplex secretome engineering enhances recombinant protein production and purity

Nathan E. Lewis, Stefan Kol, Jahir M. Gutierrez, 2019, bioRxiv.

Autophagy and apoptosis in Chinese hamster ovary cell culture

G. Lee, S. Hwang, 2008, Autophagy.

A metabolic CRISPR-Cas9 screen in Chinese hamster ovary cells identifies glutamine-sensitive genes.

David E. Ruckerbauer, N. Lewis, N. Borth, 2021, Metabolic engineering.

Comprehensive characterization of glutamine synthetase-mediated selection for the establishment of recombinant CHO cells producing monoclonal antibodies

G. Lee, Seunghyeon Shin, S. Noh, 2018, Scientific Reports.

Understanding of altered N‐glycosylation‐related gene expression in recombinant Chinese hamster ovary cells subjected to elevated ammonium concentration by digital mRNA counting

G. Lee, T. Ha, Yeon-Gu Kim, 2015, Biotechnology and bioengineering.

Effect of glutamine substitution by TCA cycle intermediates on the production and sialylation of Fc-fusion protein in Chinese hamster ovary cell culture.

G. Lee, T. Ha, 2014, Journal of biotechnology.

Microencapsulated human bone marrow cultures: A potential culture system for the clonal outgrowth of hematopoietic progenitor cells

B. Palsson, G. Lee, S. Paek, 1994, Biotechnology and bioengineering.

Estimation of autophagy pathway genes for autophagy induction: Overexpression of Atg9A does not induce autophagy in recombinant Chinese hamster ovary cells

G. Lee, Jae Seong Lee, 2012 .

Proteomic Analysis of Host Cell Protein Dynamics in the Culture Supernatants of Antibody-Producing CHO Cells

Gyun Min Lee, Jong Hwa Jin, Hyun Joo An, 2017, Scientific Reports.

High-level Expression and Purification of a Designed Angiopoietin-1 Chimeric Protein, COMP-Ang1, Produced in Chinese Hamster Ovary Cells

M. Steinmetz, G. Koh, G. Lee, 2008, The protein journal.

Case study on human α1‐antitrypsin: Recombinant protein titers obtained by commercial ELISA kits are inaccurate

H. Hansen, G. Lee, S. Kol, 2016, Biotechnology journal.

Characterization and efficacy of PKH26 as a probe to study the replication history of the human hematopoietic KG1a progenitor cell line

B. Palsson, K. Francis, S. Fong, 2002, In Vitro Cellular & Developmental Biology - Animal.

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

Sara W. Bird, Erinna F. Lee, Michael D. Kim, 2016 .

Knockout of sialidase and pro-apoptotic genes in Chinese hamster ovary cells enables the production of recombinant human erythropoietin in fed-batch cultures.

G. Lee, T. Ha, H. F. Kildegaard, 2019, Metabolic engineering.

Identification of novel miRNA targets in CHO cell lines and characterization of their impact on protein N-glycosylation

M. Andersen, N. Borth, G. Lee, 2022 .

Effect of Bcl‐xL overexpression on apoptosis and autophagy in recombinant Chinese hamster ovary cells under nutrient‐deprived condition

G. Lee, Jee Yon Kim, C. Mohan, 2009, Biotechnology and bioengineering.

Development of apoptosis-resistant dihydrofolate reductase-deficient Chinese hamster ovary cell line.

G. Lee, S. Lee, 2003, Biotechnology and Bioengineering.

Apoptosis and Autophagy Cell Engineering

G. Lee, C. Mohan, Yeon-Gu Kim, 2009 .

Development of serum-free medium supplemented with hydrolysates for the production of therapeutic antibodies in CHO cell cultures using design of experiments

Sung Hyun Kim, Gyun Min Lee, G. Lee, 2009, Applied Microbiology and Biotechnology.

Development of a serum-free medium for the production of humanized antibody from chinese hamster ovary cells using a statistical design

Gyun Min Lee, G. Lee, E. J. Kim, 1998, In Vitro Cellular & Developmental Biology - Animal.

Effect of BCL-2 overexpression on HEK293 EBNA cells in transient gene expression system

G. Lee, So Jeong Lee, 2008 .

Overexpression of Bcl-2 Inhibits the Apoptosis in rCHO Cells induced by Sodium Butyrate Treatment, Resulting in Enhanced Humanized Antibody Production

Nury Kim, G. Lee, 2000 .

Immobilization can improve the stability of hybridoma antibody productivity in serum‐free media

B. Palsson, G. Lee, G. M. Lee, 1990, Biotechnology and bioengineering.

Production of monoclonal antibody using free‐suspended and immobilized hybridoma cells: Effect of serum

Amit Varma, B. Palsson, A. Varma, 1991, Biotechnology and bioengineering.

Endoplasmic reticulum-directed recombinant mRNA displays subcellular localization equal to endogenous mRNA during transient expression in CHO cells.

G. Lee, S. Kol, Helene Faustrup Kildegaard, 2016, Biotechnology journal.

Effect of serum type and concentration on the expression ofβ-galactosidase in recombinant vaccinia virus infected HeLa S3 cells

G. Lee, Jung Hoe Kim, S. Jun, 2004, Cytotechnology.

In situ labeling of adherent cells with PKH26

B. Palsson, K. Francis, D. Oh, 2000, In Vitro Cellular & Developmental Biology - Animal.

Adaptation of Chinese hamster ovary cells to low culture temperature: cell growth and recombinant protein production.

G. Lee, S. Yoon, H. Park, 2006, Journal of biotechnology.

Streamlined in vitro screening system of synthetic signal peptides in Chinese hamster ovary cells for therapeutic protein production.

G. Lee, Soomin Park, Yeon-Gu Kim, 2023, Journal of biotechnology.

Identification of hyperosmotic stress-responsive genes in Chinese hamster ovary cells via genome-wide virus-free CRISPR/Cas9 screening

N. Lewis, Hooman Hefzi, G. Lee, 2022, bioRxiv.

Characterization of chimeric antibody producing CHO cells in the course of dihydrofolate reductase-mediated gene amplification and their stability in the absence of selective pressure.

C. Ryu, G. Lee, Sang Jick Kim, 1998, Biotechnology and bioengineering.

Revealing Key Determinants of Clonal Variation in Transgene Expression in Recombinant CHO Cells Using Targeted Genome Editing.

B. Palsson, N. Lewis, M. Samoudi, 2018, ACS synthetic biology.

Characterization of the KG1a cell line for use in a cell migration based screening assay

B. Palsson, K. Francis, G. Lee, 2002 .

Enhancement of monoclonal antibody production by immobilized hybridoma cell culture with hyperosmolar medium

G. Lee, G. M. Lee, S. Y. Park, 1995, Biotechnology and bioengineering.

Influence of co-down-regulation of caspase-3 and caspase-7 by siRNAs on sodium butyrate-induced apoptotic cell death of Chinese hamster ovary cells producing thrombopoietin.

G. Lee, Soon-Hye Park, Jae Seong Lee, 2007, Metabolic Engineering.

Protein reference mapping of dihydrofolate reductase‐deficient CHO DG44 cell lines using 2‐dimensional electrophoresis

G. Lee, Young Hwan Kim, Jae Seong Lee, 2010, Proteomics.

Relationship between cell size and specific thrombopoietin productivity in chinese hamster ovary cells during dihydrofolate reductase-mediated gene amplification

G. Lee, Y. H. Sung, J. Chung, 2001 .

Effect of Bcl‐xL overexpression on lactate metabolism in chinese hamster ovary cells producing antibody

G. Lee, T. Ha, Min Kyoung Jeon, 2013, Biotechnology progress.

Differences in optimal pH and temperature for cell growth and antibody production between two Chinese hamster ovary clones derived from the same parental clone.

Gyun Min Lee, G. Lee, Hyun Sung Kim, 2007, Journal of microbiology and biotechnology.

Application of Population Balance Model to the Loss of Hybridoma Antibody Productivity

B O Palsson, B. Palsson, A. Varma, 1991, Biotechnology progress.

Intracellular responses of antibody-producing H69K-NGD transfectoma subjected to hyperosmotic pressure

G. Lee, S. Bae, 2005 .

Stability of Chimeric Antibody Producing Transfectomas during a Long-Term Culture

G. Lee, H. Hong, S. Bae, 1995 .

Editorial Board: Biotechnology Journal 8/2023

Nathan D. Price, J. Keasling, T. Park, 2023, Biotechnology Journal.

Accelerated homology-directed targeted integration of transgenes in Chinese hamster ovary cells via CRISPR/Cas9 and fluorescent enrichment.

G. Lee, L. Pedersen, H. F. Kildegaard, 2016, Biotechnology and bioengineering.

Guidelines for the use and interpretation of assays for monitoring autophagy

Robert Clarke, Hong Jiang, Hiroyuki Ishida, 2012 .

Autophagy and its implication in Chinese hamster ovary cell culture

G. Lee, Jae Seong Lee, Eric Baek, 2013, Biotechnology Letters.

Oligomerization and Multimerization Are Critical for Angiopoietin-1 to Bind and Phosphorylate Tie2*

M. Steinmetz, R. Kammerer, B. Maco, 2005, Journal of Biological Chemistry.

Angiopoietin-2 Exocytosis Is Stimulated by Sphingosine-1-Phosphate in Human Blood and Lymphatic Endothelial Cells

S. K. Park, G. Lee, Cholsoon Jang, 2009, Arteriosclerosis, thrombosis, and vascular biology.

CHO cells in biotechnology for production of recombinant proteins: current state and further potential

G. Lee, Jee Yon Kim, Yeon-Gu Kim, 2011, Applied Microbiology and Biotechnology.

Efficient CRISPR/Cas9-mediated multiplex genome editing in CHO cells via high-level sgRNA-Cas9 complex

Byung-Kwan Cho, Yoseb Song, Jongoh Shin, 2015, Biotechnology and Bioprocess Engineering.

Effect of trisodium citrate treatment on hybridoma cell viability

B. Palsson, G. Lee, J. Gray, 1991 .

Effect of constitutively active ras overexpression on cell growth in recombinant chinese hamster ovary cells

Hongweon Lee, G. Lee, Eun Gyo Lee, 2011, Biotechnology progress (Print).

Development of a serum-free medium for the production of erythropoietin by suspension culture of recombinant Chinese hamster ovary cells using a statistical design.

Y. Ahn, G. Lee, S. Yoon, 1999, Journal of biotechnology.

Novel Glycosylated VEGF Decoy Receptor Fusion Protein, VEGF-Grab, Efficiently Suppresses Tumor Angiogenesis and Progression

S. C. Kim, Ho Min Kim, G. Koh, 2014, Molecular Cancer Therapeutics.

Untangling the mechanism of 3‐methyladenine in enhancing the specific productivity: Transcriptome analysis of recombinant Chinese hamster ovary cells treated with 3‐methyladenine

G. Lee, Jae Seong Lee, Eric Baek, 2018, Biotechnology and bioengineering.

CRISPR/Cas9-Multiplexed Editing of Chinese Hamster Ovary B4Gal-T1, 2, 3, and 4 Tailors N-Glycan Profiles of Therapeutics and Secreted Host Cell Proteins.

M. Andersen, G. Lee, S. Kol, 2018, Biotechnology journal.

Understanding of decreased sialylation of Fc‐fusion protein in hyperosmotic recombinant Chinese hamster ovary cell culture: N‐glycosylation gene expression and N‐linked glycan antennary profile

Jong Hyun Lee, G. Lee, Yeon-Gu Kim, 2017, Biotechnology and bioengineering.

Feasibility study on the use of hyperosmolar medium for improved antibody production of hybridoma cells in a long-term, repeated-fed batch culture

Gyun Min Lee, Sung Young Park, S. Park, 1995 .

Enhanced specific antibody productivity of hybridomas resulting from hyperosmotic stress is cell line-specific

Gyun Min Lee, Sung Young Park, S. Park, 1995, Biotechnology Letters.

Using Titer and Titer Normalized to Confluence Are Complementary Strategies for Obtaining Chinese Hamster Ovary Cell Lines with High Volumetric Productivity of Etanercept.

M. Andersen, N. Borth, H. Hansen, 2018, Biotechnology journal.