C. Gertzen

发表

Mutational mapping of the transmembrane binding site of the G-protein coupled receptor TGR5 and binding mode prediction of TGR5 agonists.

H. Gohlke, D. Häussinger, S. Smits, 2015, European journal of medicinal chemistry.

Synthesis of peptoid-based class I selective histone deacetylase inhibitors with chemosensitizing properties.

H. Gohlke, F. Hansen, T. Kurz, 2019, Journal of medicinal chemistry.

Design, synthesis and biological evaluation of β-peptoid-capped HDAC inhibitors with anti-neuroblastoma and anti-glioblastoma activity.

H. Gohlke, F. Hansen, T. Kurz, 2019, MedChemComm.

Alkoxyurea-Based Histone Deacetylase Inhibitors Increase Cisplatin Potency in Chemoresistant Cancer Cell Lines.

H. Gohlke, C. Romier, F. Hansen, 2017, Journal of medicinal chemistry.

Semisynthetic Analogs of the Antibiotic Fidaxomicin—Design, Synthesis, and Biological Evaluation

H. Gohlke, K. Gademann, C. Gertzen, 2020, ACS medicinal chemistry letters.

Design, Multicomponent Synthesis, and Anticancer Activity of a Focused Histone Deacetylase (HDAC) Inhibitor Library with Peptoid-Based Cap Groups.

H. Gohlke, C. Romier, F. Hansen, 2017, Journal of medicinal chemistry.

Structural assemblies of the di- and oligomeric G-protein coupled receptor TGR5 in live cells: an MFIS-FRET and integrative modelling study

H. Gohlke, C. Seidel, D. Häussinger, 2016, Scientific Reports.

Recurrent Germline Variant in RAD21 Predisposes Children to Lymphoblastic Leukemia or Lymphoma

S. Fröhling, R. Jessberger, H. Gohlke, 2022, International journal of molecular sciences.

Single MHC‐I Expression Promotes Virus‐Induced Liver Immunopathology

H. Gohlke, A. Borkhardt, A. Pandyra, 2022, Hepatology communications.

TGR5 (GPBAR1) in the Liver

H. Gohlke, D. Häussinger, V. Keitel, 2020 .

Loop 1 of APOBEC3C regulates its antiviral activity against HIV-1

H. Gohlke, D. Häussinger, Sharmistha Banerjee, 2020, bioRxiv.

Interaction of Ochratoxin A and Its Thermal Degradation Product 2′R-Ochratoxin A with Human Serum Albumin

H. Gohlke, H. Humpf, C. Gertzen, 2018, Toxins.

JAK2 p.G571S in B-cell precursor acute lymphoblastic leukemia: a synergizing germline susceptibility

H. Gohlke, A. Borkhardt, O. Haas, 2019, Leukemia.

Synthesis, Biological Evaluation and Molecular Modeling of Substituted Indeno[1,2-b]indoles as Inhibitors of Human Protein Kinase CK2

H. Gohlke, J. Delcros, C. Gertzen, 2015, Pharmaceuticals.

A new twist in ABC transporter mediated multidrug resistance – Pdr5 is a drug/proton co-transporter

S. Smits, L. Schmitt, C. Gertzen, 2021, bioRxiv.

Semisynthetic Analogs of the Antibiotic Fidaxomicin—Design, Synthesis, and Biological Evaluation

H. Gohlke, K. Gademann, C. Gertzen, 2020, ACS medicinal chemistry letters.

Effects of novel HDAC inhibitors on urothelial carcinoma cells

H. Gohlke, W. Schulz, F. Hansen, 2018, Clinical Epigenetics.

A Novel Polyester Hydrolase From the Marine Bacterium Pseudomonas aestusnigri – Structural and Functional Insights

H. Gohlke, M. Ferrer, S. Smits, 2020, Frontiers in Microbiology.

Rational design and diversity-oriented synthesis of peptoid-based selective HDAC6 inhibitors.

H. Gohlke, F. Hansen, T. Kurz, 2016, Chemical communications.

Relevance of N-terminal residues for amyloid-β binding to platelet integrin αIIbβ3, integrin outside-in signaling and amyloid-β fibril formation.

H. Gohlke, L. Donner, M. Elvers, 2018, Cellular signalling.

Identification of a conserved interface of HIV-1 and FIV Vifs with Cullin 5

H. Gohlke, D. Häussinger, C. Gertzen, 2017 .

The many facets of bile acids in the physiology and pathophysiology of the human liver

H. Gohlke, D. Häussinger, E. Mayatepek, 2021, Biological chemistry.

Biosensor-based growth-coupling and spatial separation as an evolution strategy to improve small molecule production of Corynebacterium glutamicum.

S. Noack, C. Gätgens, Julia Frunzke, 2021, Metabolic engineering.

A promiscuous ancestral enzyme´s structure unveils protein variable regions of the highly diverse metallo-β-lactamase family

H. Gohlke, H. Huber, S. Smits, 2021, Communications biology.

Phosphorylated tyrosine 93 of hepatitis C virus nonstructural protein 5A is essential for interaction with host c-Src and efficient viral replication

H. Gohlke, S. Stindt, J. Bode, 2019, The Journal of Biological Chemistry.

Development of a Biosensor Platform for Phenolic Compounds Using a Transition Ligand Strategy.

H. Gohlke, C. Gertzen, Jan Marienhagen, 2021, ACS synthetic biology.

Dimerization energetics of the G‐protein coupled bile acid receptor TGR5 from all‐atom simulations

Holger Gohlke, Lucas Wäschenbach, Christoph G W Gertzen, 2019, J. Comput. Chem..

Bile Acids and TGR5 (Gpbar1) Signaling

H. Gohlke, D. Häussinger, V. Keitel, 2020 .

Structure and Function of Redox-Sensitive Superfolder Green Fluorescent Protein Variant

H. Gohlke, K. Fritz-Wolf, S. Rahlfs, 2022, Antioxidants & redox signaling.

Time-resolved structural analysis of an RNA-cleaving DNA catalyst

G. Steger, H. Gohlke, D. Riesner, 2021, Nature.

A Membrane-proximal, C-terminal α-Helix Is Required for Plasma Membrane Localization and Function of the G Protein-coupled Receptor (GPCR) TGR5*

H. Gohlke, D. Häussinger, V. Keitel, 2013, The Journal of Biological Chemistry.

A Plurizyme with Transaminase and Hydrolase Activity Catalyzes Cascade Reactions

V. Guallar, M. Ferrer, F. Plou, 2022, Angewandte Chemie.

Time-resolved structural analysis of an RNA-cleaving DNA catalyst

G. Steger, H. Gohlke, D. Riesner, 2021, Nature.

The architecture of the 10‐23 DNAzyme and its implications for DNA‐mediated catalysis

H. Gohlke, C. Gertzen, M. Etzkorn, 2022, The FEBS journal.

Fluorescent analogs of peptoid-based HDAC inhibitors: Synthesis, biological activity and cellular uptake kinetics.

H. Gohlke, R. Nowotny, F. Hansen, 2019, Bioorganic & medicinal chemistry.

Rational design and diversity-oriented synthesis of peptoid-based selective HDAC 6 inhibitors †

H. Gohlke, F. Hansen, T. Kurz, 2016 .

Regulation of STING activity in DNA sensing by ISG15 modification.

B. Görg, C. Gertzen, N. V. Fuchs, 2023, Cell reports.

A Membrane-proximal, C-terminal α-Helix Is Required for Plasma Membrane Localization and Function of the G Protein-coupled Receptor (GPCR) TGR5*

H. Gohlke, D. Häussinger, V. Keitel, 2013, The Journal of Biological Chemistry.

Mutational mapping of the transmembrane binding site of the G-protein coupled receptor TGR5 and binding mode prediction of TGR5 agonists.

H. Gohlke, D. Häussinger, S. Smits, 2015, European journal of medicinal chemistry.

The ISG15-Protease USP18 Is a Pleiotropic Enhancer of HIV-1 Replication

C. Gertzen, Edmund Osei Kuffour, Jesko Kaiser, 2024, Viruses.