C. Lehr

发表

Transfection system of amino-functionalized calcium phosphate nanoparticles: in vitro efficacy, biodegradability, and immunogenicity study.

Babak Mostaghaci, G. Kickelbick, Julia Susewind, 2015, ACS applied materials & interfaces.

Design of starch-graft-PEI polymers: an effective and biodegradable gene delivery platform.

C. Lehr, B. Loretz, H. Yamada, 2014, Biomacromolecules.

Effect of cationic lipid and matrix lipid composition on solid lipid nanoparticle-mediated gene transfer.

R. Müller, M. Sameti, C. Lehr, 2004, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Cationic solid-lipid nanoparticles can efficiently bind and transfect plasmid DNA.

R. Müller, U. Bakowsky, C. Lehr, 2001, Journal of controlled release : official journal of the Controlled Release Society.

A nonviral DNA delivery system based on surface modified silica-nanoparticles can efficiently transfect cells in vitro.

T. Schiestel, Helmut Schmidt, M. Sameti, 2000, Bioconjugate chemistry.

Silica nanoparticles modified with aminosilanes as carriers for plasmid DNA.

T. Schiestel, Helmut Schmidt, M. Sameti, 2000, International journal of pharmaceutics.

Transfection with different colloidal systems: comparison of solid lipid nanoparticles and liposomes.

R. Müller, M. Sameti, U. Bakowsky, 2004, Journal of controlled release : official journal of the Controlled Release Society.

Design of Polyamine-Grafted Starches for Nucleotide Analogue Delivery: In Vitro Evaluation of the Anticancer Activity.

C. Lehr, B. Loretz, H. Yamada, 2016, Bioconjugate chemistry.

Enhanced uptake and siRNA-mediated knockdown of a biologically relevant gene using cyclodextrin polyrotaxane.

R. Jain, R. Jain, P. Dandekar, 2015, Journal of materials chemistry. B.

Finite dose skin mass balance including the lateral part: comparison between experiment, pharmacokinetic modeling and diffusion models.

G. Wittum, M. Heisig, C. Lehr, 2013, Journal of controlled release : official journal of the Controlled Release Society.

In vitro tools for orally inhaled drug products—state of the art for their application in pharmaceutical research and industry and regulatory challenges

C. Lehr, J. Metz, Marius Hittinger, 2021, In vitro models.

Not ready to use – overcoming pitfalls when dispersing nanoparticles in physiological media

J. Schnekenburger, C. Lehr, W. Wohlleben, 2008 .

Medium throughput breathing human primary cell alveolus-on-chip model

O. Guenat, T. Geiser, M. Frick, 2018, Scientific Reports.

Assessment of mucoadhesion by a resonant mirror biosensor.

C. Lehr, H. H. Sigurdsson, T. Loftsson, 2006, International journal of pharmaceutics.

Diverse Applications of Nanomedicine

T. Park, A. Khademhosseini, M. Prato, 2017, ACS nano.

The Interplay of Lung Surfactant Proteins and Lipids Assimilates the Macrophage Clearance of Nanoparticles

Claus-Michael Lehr, Julian Kirch, Jennifer Herrmann, 2012, PloS one.

Calcium Phosphate System for Gene Delivery: Historical Background and Emerging Opportunities.

Babak Mostaghaci, C. Lehr, B. Loretz, 2016, Current pharmaceutical design.

Cellular and Non-cellular Barriers to Particle Transport Across the Lungs

C. Lehr, Marius Hittinger, N. Schneider-Daum, 2019, Biological Responses to Nanoscale Particles.

Bioadhesive Drug Delivery Systems : Fundamentals, Novel Approaches, and Development

Claus-Michael Lehr, Donald E. Chickering, Edith Mathiowitz, 1999 .

Optical tweezers reveal relationship between microstructure and nanoparticle penetration of pulmonary mucus

Claus-Michael Lehr, Marc Schneider, Julian Kirch, 2012, Proceedings of the National Academy of Sciences.

Overcoming the pulmonary barrier: new insights to improve the efficiency of inhaled therapeutics

C. Lehr, X. Murgia, Cristiane de Souza Carvalho, 2014 .

Carrier interactions with the biological barriers of the lung: advanced in vitro models and challenges for pulmonary drug delivery.

Claus-Michael Lehr, C. Lehr, Cristiane de Souza Carvalho, 2014, Advanced drug delivery reviews.

The cell line NCl-H441 is a useful in vitro model for transport studies of human distal lung epithelial barrier.

Claus-Michael Lehr, Carsten Ehrhardt, C. Ehrhardt, 2014, Molecular pharmaceutics.

Preclinical safety and efficacy models for pulmonary drug delivery of antimicrobials with focus on in vitro models.

Claus-Michael Lehr, Nicole Schneider-Daum, C. Lehr, 2015, Advanced drug delivery reviews.

Proteomic and Lipidomic Analysis of Nanoparticle Corona upon Contact with Lung Surfactant Reveals Differences in Protein, but Not Lipid Composition.

Claus-Michael Lehr, Stefan Tenzer, Alexander Rurainski, 2015, ACS nano.

In vivo genome editing using nuclease-encoding mRNA corrects SP-B deficiency

S. Beer-Hammer, B. Nürnberg, M. Schwab, 2015, Nature Biotechnology.

Autologous Co-culture of Primary Human Alveolar Macrophages and Epithelial Cells for Investigating Aerosol Medicines. Part II: Evaluation of IL-10-loaded Microparticles for the Treatment of Lung Inflammation

C. Lehr, B. Loretz, H. Huwer, 2016, Alternatives to laboratory animals : ATLA.

Scope and relevance of a pulmonary biopharmaceutical classification system AAPS/FDA/USP Workshop March 16-17th, 2015 in Baltimore, MD

Claus-Michael Lehr, William Doub, Per Bäckman, 2016 .

Size-Limited Penetration of Nanoparticles into Porcine Respiratory Mucus after Aerosol Deposition.

N. Willenbacher, C. Lehr, U. Schaefer, 2016, Biomacromolecules.

Modelling the bronchial barrier in pulmonary drug delivery: A human bronchial epithelial cell line supplemented with human tracheal mucus

C. Lehr, B. Loretz, U. Schaefer, 2017, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Tracing molecular and structural changes upon mucolysis with N-acetyl cysteine in human airway mucus.

M. Windbergs, C. Lehr, U. Schaefer, 2017, International journal of pharmaceutics.

The role of mucus on drug transport and its potential to affect therapeutic outcomes☆

C. Lehr, B. Loretz, Marius Hittinger, 2017, Advanced drug delivery reviews.

Basic Mathematics in Skin Absorption

C. Lehr, D. Selzer, U. Schaefer, 2017 .

Kinetics of mRNA delivery and protein translation in dendritic cells using lipid-coated PLGA nanoparticles

Claus-Michael Lehr, Marcus Koch, Brigitta Loretz, 2018, Journal of Nanobiotechnology.

In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers

Claus-Michael Lehr, Hans E. Junginger, Etienne Schacht, 1992 .

A 3D co-culture of three human cell lines to model the inflamed intestinal mucosa for safety testing of nanomaterials

Julia Susewind, C. Lehr, U. Repnik, 2015, Nanotoxicology.

Co-Delivery of mRNA and pDNA Using Thermally Stabilized Coacervate-Based Core-Shell Nanosystems

C. Lehr, B. Loretz, Sangeun Lee, 2021, Pharmaceutics.

Naturally occurring reactive sulfur species, their activity against Caco-2 cells, and possible modes of biochemical action

M. Diederich, C. Lehr, C. Scherer, 2008 .

The bacterial cell envelope as delimiter of anti-infective bioavailability - An in vitro permeation model of the Gram-negative bacterial inner membrane.

M. Windbergs, C. Lehr, V. Rosilio, 2016, Journal of controlled release : official journal of the Controlled Release Society.

Relevance of the colloidal stability of chitosan/PLGA nanoparticles on their cytotoxicity profile.

C. Lehr, Marc Schneider, U. Schaefer, 2009, International journal of pharmaceutics.

Bacteriomimetic invasin-functionalized nanocarriers for intracellular delivery.

C. Lehr, Sarah Gordon, P. Dersch, 2015, Journal of controlled release : official journal of the Controlled Release Society.

Pulmonary drug delivery: from generating aerosols to overcoming biological barriers-therapeutic possibilities and technological challenges.

C. Lehr, C. Ruge, J. Kirch, 2013, The Lancet. Respiratory medicine.

Polyester-idarubicin nanoparticles and a polymer-photosensitizer complex as potential drug formulations for cell-mediated drug delivery.

Qiong Lian, C. Lehr, B. Loretz, 2014, International journal of pharmaceutics.

Nano- and microparticulate drug carriers for targeting of the inflamed intestinal mucosa.

C. Lehr, E. Collnot, H. Ali, 2012, Journal of controlled release : official journal of the Controlled Release Society.

Statistical Comparison of Dissolution Profiles to Predict the Bioequivalence of Extended Release Formulations

T. Lehr, C. Lehr, U. Schaefer, 2014, The AAPS Journal.

Permutation Test (PT) and Tolerated Difference Test (TDT): two new, robust and powerful nonparametric tests for statistical comparison of dissolution profiles.

C. Lehr, U. Schaefer, J. D. Gómez-Mantilla, 2013, International journal of pharmaceutics.

Surfactant-Free Glibenclamide Nanoparticles: Formulation, Characterization and Evaluation of Interactions with Biological Barriers

C. Lehr, B. Loretz, C. Salomon, 2021, Pharmaceutical Research.

Mucus as a barrier to lipophilic drugs.

C. Lehr, H. H. Sigurdsson, J. Kirch, 2013, International journal of pharmaceutics.

Biodegradable nanoparticles for targeted drug delivery in treatment of inflammatory bowel disease.

Y. Kawashima, H. Takeuchi, H. Yamamoto, 2001, The Journal of pharmacology and experimental therapeutics.

Bioadhesion by Means of Specific Binding of Tomato Lectin

Claus-Michael Lehr, Hans E. Junginger, H. Junginger, 1992, Pharmaceutical Research.

Size-Dependent Bioadhesion of Micro- and Nanoparticulate Carriers to the Inflamed Colonic Mucosa

Claus-Michael Lehr, Alf Lamprecht, A. Lamprecht, 2001, Pharmaceutical Research.

Computational modeling of the sugarlectin interaction

O. Kohlbacher, Hans-Peter Lenhof, C. Lehr, 2004 .

Inhalative nanomedicine—Opportunities and challenges

C. Lehr, Marc Schneider, Stephanie Hein, 2009, Inhalation toxicology.

In-silico model of skin penetration based on experimentally determined input parameters. Part II: mathematical modelling of in-vitro diffusion experiments. Identification of critical input parameters.

Gabriel Wittum, Claus-Michael Lehr, Dirk Neumann, 2008, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Optimization of the TRAP assay to evaluate specificity of telomerase inhibitors

U. Klotz, C. Lehr, U. Schaefer, 2005, Laboratory Investigation.

Spatial separation of the processing and MHC class I loading compartments for cross-presentation of the tumor-associated antigen HER2/neu by human dendritic cells

C. Lehr, M. Gottschaldt, J. Czaplewska, 2015, Oncoimmunology.

Characterization of microcapsules by confocal laser scanning microscopy: structure, capsule wall composition and encapsulation rate.

A. Lamprecht, C. Lehr, U. Schäfer, 2000, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Structural analysis of microparticles by confocal laser scanning microscopy

A. Lamprecht, C. Lehr, U. Schäfer, 2000, AAPS PharmSciTech.

Visualization and quantification of polymer distribution in microcapsules by confocal laser scanning microscopy (CLSM).

A. Lamprecht, C. Lehr, U. Schäfer, 2000, International journal of pharmaceutics.

Systematic Analysis of Composition, Interfacial Performance and Effects of Pulmonary Surfactant Preparations on Cellular Uptake and Cytotoxicity of Aerosolized Nanomaterials

D. Schwudke, C. Feldmann, C. Lehr, 2021, Small Science.

One-Step Synthesis of Nanosized and Stable Amino-Functionalized Calcium Phosphate Particles for DNA Transfection

Babak Mostaghaci, G. Kickelbick, C. Lehr, 2013 .

24 Nano-Particulate Calcium Phosphate as a Gene Delivery System

Babak Mostaghaci, C. Lehr, B. Loretz, 2012 .

Nano-Particulate Calcium Phosphate as a Gene Delivery System

Babak Mostaghaci, C. Lehr, B. Loretz, 2011 .

Calorimetric and spectrophotometric investigation of PLGA nanoparticles and their complex with DNA

C. Lehr, Marc Schneider, U. Schaefer, 2010 .

Preparation and characterization of chitosan and trimethyl-chitosanmodified poly-(ε-caprolactone) nanoparticles as DNA carriers

U. Bakowsky, G. Borchard, C. Lehr, 2005, AAPS PharmSciTech.

Modified silica particles for gene delivery

M. Sameti, C. Lehr, H. Schmidt, 2003 .

Low-temperature micronization of a peptide drug in fluid propellant: Case study cetrorelix

C. Lehr, R. Lizio, M. Damm, 2001, AAPS PharmSciTech.

CHITOSAN AND CHITOSAN DERIVATIVES AS ABSORPTION ENHANCERS FOR PEPTIDE DRUGS ACROSS MUCOSAL EPITHELIA

H. Junginger, C. Lehr, M. Thanou, 1999 .

Laser interference lithography as a new and efficient technique for micropatterning of biopolymer surface.

F. Mücklich, S. Mathur, Hao Shen, 2005, Biomaterials.

Characterization and evaluation of a modified PVPA barrier in comparison to Caco-2 cell monolayers for combined dissolution and permeation testing.

M. Windbergs, C. Lehr, U. Schaefer, 2014, Journal of controlled release : official journal of the Controlled Release Society.

Advancing human in vitro pulmonary disease models in preclinical research: opportunities for lung-on-chips

J. Sznitman, C. Lehr, Arbel Artzy-Schnirman, 2020, Expert opinion on drug delivery.

Inhalable Clarithromycin Microparticles for Treatment of Respiratory Infections

R. Hartmann, C. Lehr, Jörg Haupenthal, 2015, Pharmaceutical Research.

Extracellular vesicles as novel assay tools to study cellular interactions of anti-infective compounds - a perspective.

C. Lehr, R. Richter, 2021, Advanced drug delivery reviews.

PLGA nanocapsules improve the delivery of clarithromycin to kill intracellular Staphylococcus aureus and Mycobacterium abscessus.

P. Couvreur, M. Bischoff, R. Müller, 2019, Nanomedicine : nanotechnology, biology, and medicine.

Visualization studies of the mucoadhesive interface

H. Junginger, J. Bouwstra, J. Onderwater, 1992 .

Towards Standardized Dissolution Techniques for In Vitro Performance Testing of Dry Powder Inhalers

C. Lehr, J. Krämer, M. Klein, 2018 .

Fucosylated lipid nanocarriers loaded with antibiotics efficiently inhibit mycobacterial propagation in human myeloid cells.

R. Tampé, B. Bošnjak, R. Förster, 2021, Journal of controlled release : official journal of the Controlled Release Society.

Models using native tracheobronchial mucus in the context of pulmonary drug delivery research: Composition, structure and barrier properties.

C. Lehr, B. Loretz, Marius Hittinger, 2022, Advanced drug delivery reviews.

Human Skin Permeation Enhancement Using PLGA Nanoparticles Is Mediated by Local pH Changes

C. Lehr, Marc Schneider, U. Schaefer, 2021, Pharmaceutics.

Non-invasive delivery of nanoparticles to hair follicles: a perspective for transcutaneous immunization.

T. Ebensen, K. Schulze, C. Guzmán, 2013, Vaccine.

Intestinal transit of bioadhesive microspheres in an in situ loop in the rat—A comparative study with copolymers and blends based on poly(acrylic acid)

H. Junginger, J. Bouwstra, C. Lehr, 1990 .

A Custom-Made Device for Reproducibly Depositing Pre-metered Doses of Nebulized Drugs on Pulmonary Cells in vitro

C. Lehr, C. de Souza Carvalho-Wodarz, X. Murgia, 2021, Frontiers in Bioengineering and Biotechnology.

Transport of Metal Oxide Nanoparticles Across Calu-3 Cell Monolayers Modelling the Air-Blood Barrier

C. Lehr, U. Schaefer, W. Wohlleben, 2011 .

A new Pharmaceutical Aerosol Deposition Device on Cell Cultures (PADDOCC) to evaluate pulmonary drug absorption for metered dose dry powder formulations.

C. Lehr, U. Schaefer, Stephanie Hein, 2011, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

The Pharmaceutical Aerosol Deposition Device on Cell Cultures (PADDOCC) In Vitro System: Design and Experimental Protocol

C. Lehr, U. Schaefer, Stephanie Hein, 2010, Alternatives to laboratory animals : ATLA.

Differentiation potential of human pancreatic stem cells for epithelial- and endothelial-like cell types.

C. Lehr, N. Daum, K. Meier, 2009, Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft.

Monolayers of porcine alveolar epithelial cells in primary culture as an in vitro model for drug absorption studies.

H. Galla, C. Ehrhardt, C. Lehr, 2007, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Assessment of transport rates of proteins and peptides across primary human alveolar epithelial cell monolayers.

C. Ehrhardt, C. Lehr, H. Huwer, 2006, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Salbutamol is actively absorbed across human bronchial epithelial cell layers.

C. Ehrhardt, U. Bakowsky, C. Lehr, 2005, Pulmonary pharmacology & therapeutics.

16HBE14o- Human Bronchial Epithelial Cell Layers Express P-Glycoprotein, Lung Resistance-Related Protein, and Caveolin-1

C. Ehrhardt, C. Lehr, C. Kneuer, 2003, Pharmaceutical Research.

Automated measurement of permeation and dissolution of propranolol HCl tablets using sequential injection analysis.

P. Solich, C. Lehr, U. Schaefer, 2007, Analytica chimica acta.

Application of Chitosan for Anticancer Biopharmaceutical Delivery

C. Lehr, B. Loretz, U. Schaefer, 2012 .

Influence of vitamin E TPGS poly(ethylene glycol) chain length on apical efflux transporters in Caco-2 cell monolayers.

M. Wempe, C. Lehr, U. Schaefer, 2006, Journal of controlled release : official journal of the Controlled Release Society.

Lectin-Functionalized Liposomes for Pulmonary Drug Delivery: Interaction with Human Alveolar Epithelial Cells

G. Borchard, C. Lehr, U. Schäfer, 2001, Journal of drug targeting.

Anti-infectives in Drug Delivery-Overcoming the Gram-Negative Bacterial Cell Envelope.

C. Lehr, Sarah Gordon, Florian Graef, 2016, Current topics in microbiology and immunology.

Human Native and Reconstructed Skin Preparations for In Vitro Penetration and Permeation Studies

C. Lehr, D. Selzer, U. Schaefer, 2017 .

Influence of Human Skin Specimens Consisting of Different Skin Layers on the Result of in vitro Permeation Experiments

C. Lehr, K. Kostka, D. Neumann, 2008, Skin Pharmacology and Physiology.

TEWL measurements as a routine method for evaluating the integrity of epidermis sheets in static Franz type diffusion cells in vitro. Limitations shown by transport data testing.

C. Lehr, K. Kostka, U. Schaefer, 2006, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Interrelation of permeation and penetration parameters obtained from in vitro experiments with human skin and skin equivalents.

C. Lehr, K. Kostka, U. Schaefer, 2001, Journal of controlled release : official journal of the Controlled Release Society.

Challenges and Strategies in Drug Delivery Systems for Treatment of Pulmonary Infections.

C. Lehr, B. Loretz, X. Murgia, 2019, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Capturing the Onset of Bacterial Pulmonary Infection in Acini‐On‐Chips

J. Sznitman, C. Lehr, Shani Elias-Kirma, 2019, Advanced Biosystems.

Towards an in vitro model of cystic fibrosis small airway epithelium: characterisation of the human bronchial epithelial cell line CFBE41o-

C. Ehrhardt, C. Lehr, M. Laue, 2006, Cell and Tissue Research.

Pulmonary surfactant is indispensable in order to simulate the in vivo situation

W. Kreyling, C. Lehr, C. Schleh, 2013, Particle and Fibre Toxicology.

Stabilisation by freeze-drying of cationically modified silica nanoparticles for gene delivery.

Helmut Schmidt, M. Sameti, U. Bakowsky, 2003, International journal of pharmaceutics.

Antigen delivery via hydrophilic PEG-b-PAGE-b-PLGA nanoparticles boosts vaccination induced T cell immunity.

René Rietscher, Claus-Michael Lehr, Marc Schneider, 2016, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Nanoparticles made of fluorescence-labelled Poly(L-lactide-co-glycolide): preparation, stability, and biocompatibility.

A. Lamprecht, C. Lehr, U. Schaefer, 2006, Journal of nanoscience and nanotechnology.

Drug transport across pulmonary epithelial cell monolayers: effects of particle size, apical liquid volume, and deposition technique.

C. Lehr, H. Huwer, M. Bur, 2010, Journal of aerosol medicine and pulmonary drug delivery.

A novel cell compatible impingement system to study in vitro drug absorption from dry powder aerosol formulations.

B. Rothen‐Rutishauser, C. Lehr, H. Huwer, 2009, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Pulmonary cell culture models to study the safety and efficacy of innovative aerosol medicines

C. Lehr, M. Bur, 2008 .

New Horizons in the Development of Novel Needle-Free Immunization Strategies to Increase Vaccination Efficacy.

T. Ebensen, K. Schulze, C. Guzmán, 2016, Current topics in microbiology and immunology.

Vitamin E TPGS P-glycoprotein inhibition mechanism: influence on conformational flexibility, intracellular ATP levels, and role of time and site of access.

Claus-Michael Lehr, Kevin J Edgar, Eva-Maria Collnot, 2010, Molecular pharmaceutics.

Lectin-functionalized liposomes for pulmonary drug delivery: effect of nebulization on stability and bioadhesion.

C. Lehr, U. Schäfer, R. Abu-Dahab, 2001, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Mucoadhesive polymers in peroral peptide drug delivery. IV. Polycarbophil and chitosan are potent enhancers of peptide transport across intestinal mucosae in vitro

H. Junginger, C. Lehr, A. Boer, 1997 .

A Surface Energy Analysis of Mucoadhesion: Contact Angle Measurements on Polycarbophil and Pig Intestinal Mucosa in Physiologically Relevant Fluids

H. Junginger, J. Bouwstra, H. Boddé, 2004, Pharmaceutical Research.

An Outer Membrane Vesicle‐Based Permeation Assay (OMPA) for Assessing Bacterial Bioavailability

J. Pagés, C. Lehr, M. Koch, 2021, Advanced healthcare materials.

Screening of budesonide nanoformulations for treatment of inflammatory bowel disease in an inflamed 3D cell-culture model.

G. Storm, C. Lehr, T. Lammers, 2012, ALTEX.

Bioinspired Liposomes for Oral Delivery of Colistin to Combat Intracellular Infections by Salmonella enterica

M. Bischoff, C. Lehr, B. Loretz, 2019, Advanced healthcare materials.

Tight junctions form a barrier in porcine hair follicles.

J. Brandner, C. Lehr, M. Laue, 2016, European journal of cell biology.

A dynamic ratio of the α+ and α− isoforms of the tight junction protein ZO‐1 is characteristic of Caco‐2 cells and correlates with their degree of differentiation

C. Lehr, M. Veith, G. Minetti, 2010, Cell biology international.

A strategy for in-silico prediction of skin absorption in man.

C. Lehr, D. Selzer, K. Kostka, 2015, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Expression and Activity of Breast Cancer Resistance Protein (BCRP/ABCG2) in Human Distal Lung Epithelial Cells In Vitro

C. Ehrhardt, C. Lehr, H. Huwer, 2017, Pharmaceutical Research.

Expression of ABC-transporters in human corneal tissue and the transformed cell line, HCE-T.

K. Ruprecht, C. Ehrhardt, C. Lehr, 2007, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.

Infrared Densitometry: A Fast and Non-Destructive Method for Exact Stratum Corneum Depth Calculation for in vitro Tape-Stripping

C. Lehr, T. Hahn, K. Kostka, 2010, Skin Pharmacology and Physiology.

In vitro tools for orally inhaled drug products—state of the art for their application in pharmaceutical research and industry and regulatory challenges

C. Lehr, J. Metz, Marius Hittinger, 2021, In vitro models.

Can lifecycle management safeguard innovation in the pharmaceutical industry?

T. Friedli, C. Lehr, B. Loretz, 2018, Drug discovery today.

Influence of particle size and material properties on mucociliary clearance from the airways.

D. Klee, Xiaoying Wang, Dirk Grafahrend, 2010, Journal of aerosol medicine and pulmonary drug delivery.

In vitro assessment of transferrin-conjugated liposomes as drug delivery systems for inhalation therapy of lung cancer.

C. Ehrhardt, U. Bakowsky, C. Lehr, 2006, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Self-Assembly and Shape Control of Hybrid Nanocarriers Based on Calcium Carbonate and Carbon Nanodots

K. Rezwan, C. Lehr, B. Loretz, 2016 .

Nanomedicines for the treatment of inflammatory bowel diseases

M. Windbergs, C. Lehr, E. Collnot, 2013 .

Spray-dried Pneumococcal Membrane Vesicles are Promising Candidates for Pulmonary Immunization.

V. Presser, C. Lehr, A. Kiemer, 2022, International journal of pharmaceutics.

Murine Alveolar Epithelial Cells and Their Lentivirus-mediated Immortalisation

R. Bals, T. May, D. Wirth, 2018, Alternatives to laboratory animals : ATLA.

Computational modeling of the sugar-lectin interaction.

Claus-Michael Lehr, Hans-Peter Lenhof, Oliver Kohlbacher, 2004, Advanced drug delivery reviews.

Template‐Assisted Polyelectrolyte Encapsulation of Nanoparticles into Dispersible, Hierarchically Nanostructured Microfibers

H. Möhwald, Dayang Wang, C. Lehr, 2011, Advanced materials.

Extracellular vesicles protect glucuronidase model enzymes during freeze-drying

C. Lehr, C. de Rossi, Kathrin Fuhrmann, 2018, Scientific Reports.

Conformational change of membrane proteins leads to shape changes of red blood cells.

I. Bernhardt, U. Bakowsky, C. Lehr, 2007, Bioelectrochemistry.

Preferential uptake of chitosan-coated PLGA nanoparticles by primary human antigen presenting cells.

C. Lehr, B. Loretz, U. Kalinke, 2019, Nanomedicine : nanotechnology, biology, and medicine.

Tobacco Smoke and Inhaled Drugs Alter Expression and Activity of Multidrug Resistance-Associated Protein-1 (MRP1) in Human Distal Lung Epithelial Cells in vitro

C. Ehrhardt, C. Lehr, H. Huwer, 2020, Frontiers in Bioengineering and Biotechnology.

Analyzing the Biological Entity of Nanomaterials: Characterization of Nanomaterial Properties in Biological Matrices

A. Luch, C. Lehr, A. Haase, 2014 .

Advanced in vitro Models of the Intestinal Mucosa for Drug Delivery Studies

Julia Susewind, C. Lehr, E. Collnot, 2014 .

Design of rolipram-loaded nanoparticles: comparison of two preparation methods.

Y. Kawashima, H. Takeuchi, H. Yamamoto, 2001, Journal of controlled release : official journal of the Controlled Release Society.

Uptake of nanoparticles by alveolar macrophages is triggered by surfactant protein A.

C. Casals, C. Lehr, Marc Schneider, 2011, Nanomedicine : nanotechnology, biology, and medicine.

Lectins and glycoconjugates in drug delivery and targeting.

C. Lehr, F. Gabor, 2004, Advanced drug delivery reviews.

Nortriptyline hydrochloride skin absorption: development of a transdermal patch.

C. Lehr, U. Schäfer, A. Melero, 2008, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

A miRNA181a/NFAT5 axis links impaired T cell tolerance induction with autoimmune type 1 diabetes

J. Schug, K. Kaestner, A. Ziegler, 2018, Science Translational Medicine.

Development and characterization of film forming polymeric solutions for skin drug delivery.

C. Lehr, U. Schaefer, P. Franke, 2007, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

OCTN2-Mediated Acetyl-l-Carnitine Transport in Human Pulmonary Epithelial Cells In Vitro

C. Ehrhardt, C. Lehr, H. Huwer, 2019, Pharmaceutics.

In vitro cell response to a polymer surface micropatterned by laser interference lithography.

F. Mücklich, S. Mathur, Hao Shen, 2005, Biomacromolecules.

Aspherical and Spherical InvA497-Functionalized Nanocarriers for Intracellular Delivery of Anti-Infective Agents

R. Hartmann, C. Lehr, Rolf Müller, 2018, Pharmaceutical Research.

Human alveolar epithelial cells expressing tight junctions to model the air-blood barrier.

U. Fischer, E. Meese, T. May, 2016, ALTEX.

Monolayers of Human Alveolar Epithelial Cells in Primary Culture for Pulmonary Absorption and Transport Studies

V. H. Lee, H. Schäfers, C. Lehr, 1999, Pharmaceutical Research.

Large Porous Particle Impingement on Lung Epithelial Cell Monolayers—Toward Improved Particle Characterization in the Lung

C. Ehrhardt, C. Lehr, J. Hanes, 2003, Pharmaceutical Research.

Dimethylaminoethyl methacrylate copolymer-siRNA nanoparticles for silencing a therapeutically relevant gene in macrophages

R. Jain, P. Dandekar, C. Lehr, 2015 .

Targeted delivery of Cyclosporine A by polymeric nanocarriers improves the therapy of inflammatory bowel disease in a relevant mouse model

C. Lehr, M. Recio, R. Giner, 2017, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Budesonide Loaded PLGA Nanoparticles for Targeting the Inflamed Intestinal Mucosa—Pharmaceutical Characterization and Fluorescence Imaging

M. Windbergs, C. Lehr, B. Weigmann, 2015, Pharmaceutical Research.

Budesonide loaded nanoparticles with pH-sensitive coating for improved mucosal targeting in mouse models of inflammatory bowel diseases.

M. Neurath, M. Windbergs, C. Lehr, 2014, Journal of controlled release : official journal of the Controlled Release Society.

P-glycoprotein (MDR1) functional activity in human alveolar epithelial cell monolayers

M. Gumbleton, C. Ehrhardt, C. Lehr, 2007, Cell and Tissue Research.

Spray-dried multidrug particles for pulmonary co-delivery of antibiotics with N-acetylcysteine and curcumin-loaded PLGA-nanoparticles.

C. Lehr, Marc Schneider, C. de Souza Carvalho-Wodarz, 2020, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Ciprofloxacin‐loaded PLGA nanoparticles against cystic fibrosis P. aeruginosa lung infections

C. Lehr, Marc Schneider, N. Schneider-Daum, 2017, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Differential cell reaction upon Toll-like receptor 4 and 9 activation in human alveolar and lung interstitial macrophages

L. Gortner, A. Meyerhans, C. Lehr, 2010, Respiratory research.

PLGA Nanoparticles Stabilized with Cationic Surfactant: Safety Studies and Application in Oral Delivery of Paclitaxel to Treat Chemical-Induced Breast Cancer in Rat

C. Lehr, M. R. Kumar, V. Bhardwaj, 2009, Pharmaceutical Research.

Models of the alveolar epithelium

M. Gumbleton, C. Lehr, S. Fuchs, 2002 .

Safety assessment of excipients (SAFE) for orally inhaled drug products.

C. Lehr, J. Metz, Marius Hittinger, 2020, ALTEX.

Mono- and Cocultures of Bronchial and Alveolar Epithelial Cells Respond Differently to Proinflammatory Stimuli and Their Modulation by Salbutamol and Budesonide.

C. Lehr, H. Huwer, Marius Hittinger, 2015, Molecular pharmaceutics.

Differentiation of human alveolar epithelial cells in primary culture: morphological characterization and synthesis of caveolin-1 and surfactant protein-C

K. Roemer, M. Gumbleton, C. Lehr, 2002, Cell and Tissue Research.

The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB

Gianvito Grasso, M. Deriu, S. Bourdoulous, 2019, Journal of Nanobiotechnology.

Inverse micellar sugar glass (IMSG) nanoparticles for transfollicular vaccination.

T. Ebensen, K. Schulze, C. Guzmán, 2015, Journal of controlled release : official journal of the Controlled Release Society.

Editorial: Innovative In Vitro Models for Pulmonary Physiology and Drug Delivery in Health and Disease

J. Sznitman, C. Lehr, L. Yeo, 2021, Frontiers in Bioengineering and Biotechnology.

Decoding (patho-)physiology of the lung by advanced in vitro models for developing novel anti-infectives therapies.

C. Kloft, C. Lehr, C. Carvalho-Wodarz, 2020, Drug discovery today.

A New Immortalized Human Alveolar Epithelial Cell Model to Study Lung Injury and Toxicity on a Breathing Lung-On-Chip System

O. Guenat, T. May, Arunima Sengupta, 2022, Frontiers in Toxicology.

Chapter 5.1:Nanostructures for Overcoming the Pulmonary Barriers: Physiological Considerations and Mechanistic Issues

C. Lehr, J. Hanes, C. Schneider, 2012 .

Vitamin D Deficiency Does Not Result in a Breach of Host Defense in Murine Models of Pneumonia

R. Bals, C. Herr, C. Beisswenger, 2016, Infection and Immunity.

Tofacitinib Loaded Squalenyl Nanoparticles for Targeted Follicular Delivery in Inflammatory Skin Diseases

T. Vogt, C. Lehr, B. Loretz, 2020, Pharmaceutics.

Pulmonary drug delivery: medicines for inhalation.

C. Lehr, Marc Schneider, Stephanie Hein, 2010, Handbook of experimental pharmacology.

Porcine Alveolar Epithelial Cells in Primary Culture: Morphological, Bioelectrical and Immunocytochemical Characterization

H. Galla, C. Lehr, M. Laue, 2006, Pharmaceutical Research.

Biopharmaceutical in vitro characterization of CPZEN-45, a drug candidate for inhalation therapy of tuberculosis.

C. Ehrhardt, C. Lehr, A. Hickey, 2013, Therapeutic delivery.

Isolation and culture of human alveolar epithelial cells.

C. Ehrhardt, C. Lehr, Kwang-Jin Kim, 2005, Methods in Molecular Medicine.

Combining MucilAir™ and Vitrocell® Powder Chamber for the In Vitro Evaluation of Nasal Ointments in the Context of Aerosolized Pollen

C. Lehr, Marius Hittinger, U. Bock, 2018, Pharmaceutics.

Tissue slice model of human lung cancer to investigate telomerase inhibition by nanoparticle delivery of antisense 2'-O-methyl-RNA.

U. Klotz, C. Lehr, B. Loretz, 2011, International journal of pharmaceutics.

Cellular responses after exposure of lung cell cultures to secondary organic aerosol particles.

T. Geiser, U. Baltensperger, M. Kalberer, 2010, Environmental science & technology.

Modeling the Effect of Hydrophobicity on the Passive Permeation of Solutes across a Bacterial Model Membrane

R. Hartmann, O. Kalinina, C. Lehr, 2022, J. Chem. Inf. Model..

Quantification of nanoparticle uptake into hair follicles in pig ear and human forearm.

J. Reichrath, T. Vogt, J. Schäfer, 2014, Journal of controlled release : official journal of the Controlled Release Society.

Erratum to: Scope and relevance of a pulmonary biopharmaceutical classification system AAPS/FDA/USP Workshop March 16-17th, 2015 in Baltimore, MD

W. Doub, M. Sakagami, C. Lehr, 2016 .

Depletion of alveolar macrophages by clodronate-liposomes aggravates ischemia-reperfusion injury of the lung.

H. Schäfers, H. Wada, M. Menger, 2005, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

IL-17A-mediated expression of epithelial IL-17C promotes inflammation during acute Pseudomonas aeruginosa pneumonia

R. Bals, F. Seiler, C. Herr, 2016, Pneumologie.

Expression and function of the epithelial sodium channel δ-subunit in human respiratory epithelial cells in vitro

B. Harvey, C. Ehrhardt, C. Lehr, 2015, Pflügers Archiv - European Journal of Physiology.

Lectin-mediated Drug Delivery: Discrimination Between Cytoadhesion and Cytoinvasion and Evidence for Lysosomal Accumulation of Wheat Germ Agglutinin in the Caco-2 Model

M. Wirth, C. Lehr, C. Kneuer, 2002, Journal of drug targeting.

Tobramycin Liquid Crystal Nanoparticles Eradicate Cystic Fibrosis-Related Pseudomonas aeruginosa Biofilms.

C. Prestidge, C. Lehr, C. Carvalho-Wodarz, 2021, Small.

A hydrogel-based in vitro assay for the fast prediction of antibiotic accumulation in Gram-negative bacteria

R. Hartmann, M. Vielhaber, O. Kalinina, 2020, Materials today. Bio.

Fate of insulin during transit across rat alveolar epithelial cell monolayers

V. H. Lee, C. Lehr, H. Yamahara, 1994 .

Bronchial epithelial cell cultures

H. Junginger, C. Ehrhardt, G. Borchard, 2002 .

Calcifediol‐loaded liposomes for local treatment of pulmonary bacterial infections

R. Bals, C. Herr, C. Lehr, 2017, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Niosomes for oral delivery of peptide drugs

H. Junginger, J. Bouwstra, C. Lehr, 1992 .

In vitro and in vivo performance of biocompatible negatively-charged salbutamol-loaded nanoparticles.

Xiaoying Wang, T. Kissel, C. Lehr, 2010, Journal of controlled release : official journal of the Controlled Release Society.

Nanoencapsulation in Lipid-Core Nanocapsules Controls Mometasone Furoate Skin Permeability Rate and Its Penetration to the Deeper Skin Layers

C. Lehr, U. Schaefer, A. Melero, 2014, Skin Pharmacology and Physiology.

BACTERIAL INVASION FACTORS AND LECTINS AS SECOND-GENERATION BIOADHESIVES

D. Jahn, C. Lehr, E. Haltner, 1999 .

Simulated tempering-enhanced umbrella sampling improves convergence of free energy calculations of drug membrane permeation

J. Hub, C. Lehr, C. F. Sousa, 2022, bioRxiv.

Starch-Chitosan Polyplexes: A Versatile Carrier System for Anti-Infectives and Gene Delivery

C. Lehr, B. Loretz, J. Herrmann, 2018, Polymers.

Squalenoylation of Chitosan: A Platform for Drug Delivery?

P. Couvreur, C. Lehr, B. Loretz, 2015, Biomacromolecules.

Micro-rheological properties of lung homogenates correlate with infection severity in a mouse model of Pseudomonas aeruginosa lung infection

R. Hartmann, R. Bals, C. Herr, 2020, Scientific Reports.

Invasin-functionalized liposome nanocarriers improve the intracellular delivery of anti-infective drugs

C. Lehr, Sarah Gordon, P. Dersch, 2016 .

Macrophage uptake of cylindrical microparticles investigated with correlative microscopy.

C. Lehr, Marc Schneider, Marius Hittinger, 2015, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Macrophage uptake of cylindrical micropar cles inves gated with correla ve microscopy

C. Lehr, N. Schneider-Daum, Schneider, 2015 .

Coupling quaternary ammonium surfactants to the surface of liposomes improves both antibacterial efficacy and host cell biocompatibility.

F. Nicotra, F. Re, C. Lehr, 2020, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Transport of Proteolytic Enzymes Across Caco-2 Cell Monolayers

R. Fuchs, G. Borchard, C. Lehr, 1998, Pharmaceutical Research.

Coupling of biotin-(poly(ethylene glycol))amine to poly(D,L-lactide-co-glycolide) nanoparticles for versatile surface modification.

C. Lehr, Marc Schneider, D. Neumann, 2007, Bioconjugate chemistry.

Crystal suspensions of poorly soluble peptides for intra-articular application: a novel approach for biorelevant assessment of their in vitro release.

M. Windbergs, C. Lehr, M. Harms, 2014, International journal of pharmaceutics.

pH-Dependent morphology and optical properties of lysine-derived molecular biodynamers

C. Lehr, B. Loretz, M. Koch, 2020 .

Nanoencapsulation of a glucocorticoid improves barrier function and anti‐inflammatory effect on monolayers of pulmonary epithelial cell lines

C. Lehr, S. Guterres, A. Pohlmann, 2017, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Improving the oral delivery of benznidazole nanoparticles by optimizing the formulation parameters through a design of experiment and optimization strategy.

C. Lehr, B. Loretz, H. Goicoechea, 2022, Colloids and surfaces. B, Biointerfaces.

Impact of PEG and PEG-b-PAGE modified PLGA on nanoparticle formation, protein loading and release.

Tobias C. Majdanski, U. Schubert, C. Lehr, 2016, International journal of pharmaceutics.

Development of artemether-loaded nanostructured lipid carrier (NLC) formulation for topical application.

M. Windbergs, C. Lehr, P. Nnamani, 2014, International journal of pharmaceutics.

Proteoid biodynamers for safe mRNA transfection via pH-responsive nanorods enabling endosomal escape.

C. Lehr, B. Loretz, M. Koch, 2022, Journal of controlled release : official journal of the Controlled Release Society.

Human airway mucus alters susceptibility of Pseudomonas aeruginosa biofilms to tobramycin, but not colistin

S. Häussler, C. Lehr, S. Wronski, 2018, The Journal of antimicrobial chemotherapy.

The molecular basis of bioadhesion

C. Lehr, 1998 .

Exploring the permeation of fluoroquinolone metalloantibiotics across outer membrane porins by combining molecular dynamics simulations and a porin-mimetic in vitro model.

João T. S. Coimbra, P. Fernandes, M. Ramos, 2021, Biochimica et biophysica acta. Biomembranes.

Towards the sustainable discovery and development of new antibiotics

H. Petković, I. Gilbert, M. Lindvall, 2021, Nature Reviews Chemistry.

A hydrophobic starch polymer for nanoparticle-mediated delivery of docetaxel.

R. Jain, P. Dandekar, C. Lehr, 2012, Macromolecular bioscience.

Tissue distribution of moxaverine-hydrochloride in the rabbit eye and plasma.

V. H. Lee, C. Ehrhardt, C. Lehr, 2005, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.

Mastering the Gram-Negative Bacterial Barrier - Chemical Approaches to Increase Bacterial Bioavailability of Antibiotics.

C. Lehr, A. Hirsch, R. Richter, 2021, Advanced drug delivery reviews.

Lectin-sugar interaction. Calculated versus experimental binding energies.

O. Kohlbacher, Hans-Peter Lenhof, C. Lehr, 2002, European journal of biochemistry.

Calculated versus experimental binding energies

O. Kohlbacher, Hans-Peter Lenhof, C. Lehr, 2002 .

Lectin-mediated drug delivery: the second generation of bioadhesives.

C. Lehr, Claus-Michael Lehr, 2000, Journal of controlled release : official journal of the Controlled Release Society.

Nanoparticles--an efficient carrier for drug delivery into the hair follicles.

Claus-Michael Lehr, Heike Richter, Ulrike Blume-Peytavi, 2007, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Soluplus® as an effective absorption enhancer of poorly soluble drugs in vitro and in vivo.

Claus-Michael Lehr, Eva-Maria Collnot, Dejan Djuric, 2012, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Influences of process parameters on preparation of microparticle used as a carrier system for omega - 3 unsaturated fatty acid ethyl esters used in supplementary nutrition.

A. Lamprecht, C. Lehr, U. Schäfer, 2001, Journal of microencapsulation.

Formulation and evaluation of transdermal nanogel for delivery of artemether

C. Lehr, A. Attama, K. Ofokansi, 2021, Drug Delivery and Translational Research.

A Design of Experiment Study of Nanoprecipitation and Nano Spray Drying as Processes to Prepare PLGA Nano- and Microparticles with Defined Sizes and Size Distributions

Claus-Michael Lehr, Eva-Maria Collnot, Steffi Hansen, 2015, Pharmaceutical Research.

Drug delivery for fighting infectious diseases: a global perspective

Y. Oh, C. Lehr, B. Loretz, 2021, Drug Delivery and Translational Research.

Sustained-release liquisolid compact tablets containing artemether–lumefantrine as alternate-day regimen for malaria treatment to improve patient compliance

M. Windbergs, C. Lehr, A. Attama, 2016, International journal of nanomedicine.

In-silico model of skin penetration based on experimentally determined input parameters. Part I: experimental determination of partition and diffusion coefficients.

Gabriel Wittum, Claus-Michael Lehr, Dirk Neumann, 2008, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Reconstructed Human Epidermis for Skin Absorption Testing: Results of the German Prevalidation Study

Claus-Michael Lehr, Elisabeth Schmidt, Horst Spielmann, 2006, Alternatives to laboratory animals : ATLA.

In vitro skin absorption of butyl methoxydibenzoylmethane determined in human epidermis and in a reconstituted human epidermis model

C. Lehr, M. Liebsch, H. Kandárová, 2006 .

Finite dose skin penetration: a comparison of concentration-depth profiles from experiment and simulation

Gabriel Wittum, Arne Naegel, Claus-Michael Lehr, 2011, Comput. Vis. Sci..

Second-generation lung-on-a-chip with an array of stretchable alveoli made with a biological membrane

O. Guenat, T. Geiser, C. Lehr, 2021, Communications biology.

Advanced in vitro lung-on-chip platforms for inhalation assays: From prospect to pipeline.

Josué Sznitman, Arbel Artzy-Schnirman, Nina Hobi, 2019, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Drug Distribution in Human Skin Using Two Different In Vitro Test Systems: Comparison with In Vivo Data

Claus-Michael Lehr, C. Lehr, K. Kostka, 2000, Pharmaceutical Research.

Human skin and skin equivalents to study dermal penetration and permeation

N. Zghoul, C. Lehr, U. Schäfer, 2002 .

Human skin penetration of flufenamic acid: in vivo/in vitro correlation (deeper skin layers) for skin samples from the same subject.

Claus-Michael Lehr, Ulrich F Schaefer, C. Lehr, 2002, The Journal of investigative dermatology.

MUCOADHESIVE POLYMERS IN PERORAL PEPTIDE DRUG DELIVERY. I. INFLUENCE OF MUCOADHESIVE EXCIPIENTS ON THE PROTEOLYTIC ACTIVITY OF INTESTINAL ENZYMES

H. Junginger, C. Lehr, A. Boer, 1996 .

The human epidermis models EpiSkin, SkinEthic and EpiDerm: an evaluation of morphology and their suitability for testing phototoxicity, irritancy, corrosivity, and substance transport.

P. Wertz, C. Lehr, U. Schaefer, 2005, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology.

Sangeeta Khare, Carsten Kneuer, Uwe Marx, 2015, ALTEX.

Antibiotic-free nanotherapeutics: ultra-small, mucus-penetrating solid lipid nanoparticles enhance the pulmonary delivery and anti-virulence efficacy of novel quorum sensing inhibitors.

R. Hartmann, C. Lehr, Marc Schneider, 2014, Journal of controlled release : official journal of the Controlled Release Society.

Improved input parameters for diffusion models of skin absorption.

Claus-Michael Lehr, Steffi Hansen, Ulrich F Schaefer, 2013, Advanced drug delivery reviews.

Bioadhesive polymers for the peroral delivery of peptide drugs

Claus-Michael Lehr, Hans E. Junginger, H. L. Lueßen, 1994 .

pH profiles in human skin: influence of two in vitro test systems for drug delivery testing.

Ulrich F Schaefer, C. Lehr, K. Kostka, 2003, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Delivery of ethinylestradiol from film forming polymeric solutions across human epidermis in vitro and in vivo in pigs.

C. Lehr, U. Schaefer, P. Franke, 2007, Journal of controlled release : official journal of the Controlled Release Society.

In vitro models for evaluating safety and efficacy of novel technologies for skin drug delivery.

M. Windbergs, C. Lehr, Viktoria Planz, 2016, Journal of controlled release : official journal of the Controlled Release Society.

A surface energy analysis of mucoadhesion II. Prediction of mucoadhesive performance by spreading coefficients

H. Junginger, J. Bouwstra, H. Boddé, 1993 .

The Use of Reconstructed Human Epidermis for Skin Absorption Testing: Results of the Validation Study

Claus-Michael Lehr, Elisabeth Schmidt, Horst Spielmann, 2008, Alternatives to laboratory animals : ATLA.

Comparison of bovine udder skin with human and porcine skin in percutaneous permeation experiments.

C. Lehr, M. Kietzmann, J. Stahl, 2006, Alternatives to laboratory animals : ATLA.

A Comparative Evaluation of Corneal Epithelial Cell Cultures for Assessing Ocular Permeability

C. Ehrhardt, C. Lehr, Marc Schneider, 2008, Alternatives to laboratory animals : ATLA.

Co-culture of human alveolar epithelial (hAELVi) and macrophage (THP-1) cell lines.

Claus-Michael Lehr, Nicole Schneider-Daum, Brigitta Loretz, 2018, ALTEX.

Nanoparticle-Based Mucosal Vaccines Targeting Tumor-Associated Antigens to Human Dendritic Cells.

C. Lehr, M. Gottschaldt, J. Czaplewska, 2016, Journal of biomedical nanotechnology.

Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and an Alkylquinolone Quorum Sensing Inhibitor Enable the Eradication of P. aeruginosa Biofilm Infections

R. Hartmann, P. Couvreur, R. Müller, 2020, Angewandte Chemie.

Ex Vivo Permeation of Cystine across Bovine Corneas - A Step towards the Development of an Antioxidant Eye Drop for Cataract Prevention

C. Lehr, I. Rupenthal, U. Schaefer, 2012 .

Not just for tumor targeting: unmet medical needs and opportunities for nanomedicine.

R. Zentel, C. Lehr, E. Lepeltier, 2015, Nanomedicine.

Preparation and characterization of cationic PLGA nanospheres as DNA carriers.

U. Bakowsky, C. Lehr, C M Lehr, 2004, Biomaterials.

Self-Assembly of β-Lactoglobulin and Acacia Gum in Aqueous Solvent: Structure and Phase-Ordering Kinetics

C. Sánchez, C. Lehr, J. Hardy, 2002 .

Non-invasive determination of cellular oxygen consumption as novel cytotoxicity assay for nanomaterials

Michael Veith, Claus-Michael Lehr, C. Lehr, 2014, Nanotoxicology.

Models for Skin Absorption and Skin Toxicity Testing

Claus-Michael Lehr, Marc Schneider, Steffi Hansen, 2008 .

Wet chemical modification of PTFE implant surfaces with a specific cell adhesion molecule

H. Schäfers, D. Jahn, U. Bakowsky, 2002 .

Lectin-mediated drug targeting: history and applications.

C. Lehr, J. Woodley, C. Bies, 2004, Advanced drug delivery reviews.

A three-dimensional coculture of enterocytes, monocytes and dendritic cells to model inflamed intestinal mucosa in vitro.

C. Lehr, F. Leonard, E. Collnot, 2010, Molecular pharmaceutics.

Hyaluronic acid-modified DOTAP/DOPE liposomes for the targeted delivery of anti-telomerase siRNA to CD44-expressing lung cancer cells.

Claus-Michael Lehr, Elias Fattal, Silvia Arpicco, 2009, Oligonucleotides.

Influence of Nanoencapsulation on Human Skin Transport of Flufenamic Acid

F. Stracke, C. Lehr, K. Kostka, 2006, Skin Pharmacology and Physiology.

Multiphoton microscopy for the investigation of dermal penetration of nanoparticle-borne drugs.

Karsten König, Claus-Michael Lehr, Marc Schneider, 2006, The Journal of investigative dermatology.

Selective follicular targeting by modification of the particle sizes.

J. Lademann, W. Sterry, C. Lehr, 2011, Journal of controlled release : official journal of the Controlled Release Society.

A Monoclonal Human Alveolar Epithelial Cell Line (“Arlo”) with Pronounced Barrier Function for Studying Drug Permeability and Viral Infections

J. Walter, J. Cinatl, G. Gasparoni, 2023, Advanced science.

Influences of process parameters on nanoparticle preparation performed by a double emulsion pressure homogenization technique.

A. Lamprecht, C. Lehr, P. Maincent, 2000, International journal of pharmaceutics.

Biodegradable monodispersed nanoparticles prepared by pressure homogenization-emulsification.

A. Lamprecht, C. Lehr, P. Maincent, 1999, International journal of pharmaceutics.

The potential of mucoadhesive polymers in enhancing intestinal peptide drug absorption. III: Effects of chitosan-glutamate and carbomer on epithelial tight junctions in vitro

Gerrit Borchard, Hans E. Junginger, H. Junginger, 1996 .

PerfuPul—A Versatile Perfusable Platform to Assess Permeability and Barrier Function of Air Exposed Pulmonary Epithelia

J. Sznitman, C. Lehr, N. Schneider-Daum, 2021, Frontiers in Bioengineering and Biotechnology.

Medium throughput breathing human primary cell alveolus-on-chip model

O. Guenat, T. Geiser, M. Frick, 2018, Scientific Reports.

Cell and tissue-based in vitro models for improving the development of oral inhalation drug products.

Claus-Michael Lehr, Nicole Schneider-Daum, C. Lehr, 2017, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Autologous Co-culture of Primary Human Alveolar Macrophages and Epithelial Cells for Investigating Aerosol Medicines. Part I: Model Characterisation

C. Lehr, H. Huwer, R. Scherließ, 2016, Alternatives to laboratory animals : ATLA.

Confocal and two-photon fluorescence microscopy

A. Lamprecht, C. Lehr, 2002 .

Charge-dependent interaction of self-emulsifying oil formulations with Caco-2 cells monolayers: binding, effects on barrier function and cytotoxicity.

C. Lehr, S. Benita, E. Haltner, 2000, International journal of pharmaceutics.

Efficient telomerase inhibition in human non-small cell lung cancer cells by liposomal delivery of 2'-O-methyl-RNA.

U. Klotz, C. Lehr, U. Schaefer, 2009, Journal of pharmaceutical sciences.

Semi-Automated Nanoprecipitation-System—An Option for Operator Independent, Scalable and Size Adjustable Nanoparticle Synthesis

René Rietscher, Carolin Thum, Claus-Michael Lehr, 2014, Pharmaceutical Research.

Effects of the Mucoadhesive Polymer Polycarbophil on the Intestinal Absorption of a Peptide Drug in the Rat

H. Junginger, J. Bouwstra, C. Lehr, 1992, The Journal of pharmacy and pharmacology.

Dissolution Techniques for In Vitro Testing of Dry Powders for Inhalation

C. Lehr, Marc Schneider, M. Wolkenhauer, 2012, Pharmaceutical Research.

A Model for the Transient Subdiffusive Behavior of Particles in Mucus.

Claus-Michael Lehr, Christian Wagner, Ulrich F Schaefer, 2017, Biophysical journal.

An estimate of turnover time of intestinal mucus gel layer in the rat in situ loop

Claus-Michael Lehr, Hans E. Junginger, Josef J. Tukker, 1991 .

Drug delivery to the inflamed intestinal mucosa- targeting technologies and human cell culture models for better therapies of IBD.

A. Lamprecht, C. Lehr, B. Loretz, 2021, Advanced drug delivery reviews.

Microbiota and cancer: In vitro and in vivo models to evaluate nanomedicines.

C. Passirani, C. Lehr, B. Loretz, 2020, Advanced drug delivery reviews.

Cell culture models of the respiratory tract relevant to pulmonary drug delivery.

C. Lehr, E. Haltner, A Steimer, 2005, Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.

Extracellular vesicles as antigen carriers for novel vaccination avenues.

C. Lehr, G. Fuhrmann, Mina Mehanny, 2021, Advanced drug delivery reviews.

Nanoparticles for transcutaneous vaccination

C. Lehr, S. Hansen, 2012, Microbial biotechnology.

The Role of Corneocytes in Skin Transport Revised—A Combined Computational and Experimental Approach

Gabriel Wittum, Claus-Michael Lehr, Dirk Neumann, 2009, Pharmaceutical Research.

Bioadhesion technologies for the delivery of peptide and protein drugs to the gastrointestinal tract.

C. Lehr, C M Lehr, Claus-Michael Lehr, 1994, Critical reviews in therapeutic drug carrier systems.

In vitro toxicological screening of nanoparticles on primary human endothelial cells and the role of flow in modulating cell response

C. Domenici, A. Ahluwalia, N. Ucciferri, 2014, Nanotoxicology.

Mechanism of inhibition of P-glycoprotein mediated efflux by vitamin E TPGS: influence on ATPase activity and membrane fluidity.

R. Kappl, M. Wempe, C. Lehr, 2007, Molecular pharmaceutics.

Chemical crosslinking of urokinase to pulmonary surfactant protein B for targeting alveolar fibrin

C. Ruppert, W. Seeger, A. Günther, 2003, Thrombosis and Haemostasis.

Developments in the area of bioadhesive drug delivery systems

Claus-Michael Lehr, C. Lehr, Jochen Haas, 2002, Expert opinion on biological therapy.

Biodegradable starch derivatives with tunable charge density—synthesis, characterization, and transfection efficiency

C. Lehr, B. Loretz, C. Thiele, 2017, Drug Delivery and Translational Research.

Nanocarriers for optimizing the balance between interfollicular permeation and follicular uptake of topically applied clobetasol to minimize adverse effects.

T. Vogt, C. Lehr, D. Selzer, 2016, Journal of controlled release : official journal of the Controlled Release Society.

Simultaneous In Vivo Visualization and Localization of Solid Oral Dosage Forms in the Rat Gastrointestinal Tract by Magnetic Resonance Imaging (MRI)

C. Lehr, J. Rosenberg, J. Seega, 1997, Pharmaceutical Research.

Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration.

H. M. Nielsen, K. Braeckmans, M. Ogris, 2019, Journal of controlled release : official journal of the Controlled Release Society.

Nano- and microscaled particles for drug targeting to inflamed intestinal mucosa: a first in vivo study in human patients.

J. Schulzke, C. Lehr, A. Stallmach, 2013, Journal of controlled release : official journal of the Controlled Release Society.

Mucoadhesive Polymers in Peroral Peptide Drug Delivery. II. Carbomer and Polycarbophil Are Potent Inhibitors of the Intestinal Proteolytic Enzyme Trypsin

Gerrit Borchard, Hans E. Junginger, H. Junginger, 1995, Pharmaceutical Research.

Chemical coupling of a monoclonal antisurfactant protein-B antibody to human urokinase for targeting surfactant-incorporating alveolar fibrin.

C. Ruppert, W. Seeger, A. Günther, 2002, Bioconjugate chemistry.

PEG-functionalized microparticles selectively target inflamed mucosa in inflammatory bowel disease.

Claus-Michael Lehr, Christian Lautenschläger, Andreas Stallmach, 2013, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Nanoparticle mediated delivery of 2'-O-methyl-RNA leads to efficient telomerase inhibition and telomere shortening in human lung cancer cells.

U. Klotz, C. Lehr, U. Schaefer, 2010, Lung cancer.

miRNA92a targets KLF2 and the phosphatase PTEN signaling to promote human T follicular helper precursors in T1D islet autoimmunity

A. Ziegler, A. Waisman, M. Pfaffl, 2016, Proceedings of the National Academy of Sciences.

Chitosan-coated PLGA nanoparticles for DNA/RNA delivery: effect of the formulation parameters on complexation and transfection of antisense oligonucleotides.

Claus-Michael Lehr, Marc Schneider, Ulrich F Schaefer, 2007, Nanomedicine : nanotechnology, biology, and medicine.

Determination of the rheological properties of Matrigel for optimum seeding conditions in microfluidic cell cultures

E. L. Moreno, S. Hachi, C. Lehr, 2018, AIP Advances.

Study of β-lactoglobulin/acacia gum complex coacervation by diffusing-wave spectroscopy and confocal scanning laser microscopy

C. Kruif, C. Sánchez, A. Lamprecht, 2001 .

Interaction of metal oxide nanoparticles with lung surfactant protein A.

Claus-Michael Lehr, Wendel Wohlleben, Christine Schulze, 2011, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Binding, uptake, and transport of hypericin by Caco-2 cell monolayers.

C. Lehr, U. Schaefer, W. Schneider, 1997, Journal of pharmaceutical sciences.

Effect of PEGylation on the stability of liposomes during nebulisation and in lung surfactant.

W. Seeger, T. Gessler, T. Kissel, 2006, Journal of nanoscience and nanotechnology.

Transferring Microclusters of P. aeruginosa Biofilms to the Air-Liquid Interface of Bronchial Epithelial Cells for Repeated Deposition of Aerosolized Tobramycin.

C. Lehr, D. Krug, C. de Souza Carvalho-Wodarz, 2021, ACS infectious diseases.

Electrospinning as a novel fabrication technique for drug delivery and tissue engineering

M. Windbergs, C. Lehr, U. Kazmaier, 2017 .

Lectins and bacterial invasion factors for controlling endo- and transcytosis of bioadhesive drug carrier systems☆

C. Lehr, E. Haltner, J. Easson, 1997 .

Organic cation transporter function in different in vitro models of human lung epithelium.

C. Ehrhardt, C. Lehr, H. Huwer, 2015, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Chemically modified hCFTR mRNAs recuperate lung function in a mouse model of cystic fibrosis

N. Pedemonte, C. Seitz, R. Handgretinger, 2018, Scientific Reports.

Lessons Learned from Pharmaceutical Nanomaterials

C. Lehr, B. Loretz, Emad Malaeksefat, 2014 .

Organic Cation Transport in Rabbit Alveolar Epithelial Cell Monolayers

V. H. Lee, Jie Shen, F. Yamashita, 1999, Pharmaceutical Research.

A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms

R. Hartmann, R. Bals, W. Blankenfeldt, 2021, Advanced science.

BIOADHESIVE DRUG DELIVERY SYSTEMS FOR ORAL APPLICATION

C. Lehr, 1992 .

Macro- and microrheological properties of mucus surrogates in comparison to native intestinal and pulmonary mucus.

C. Lehr, B. Loretz, C. Wagner, 2019, Biomacromolecules.

Towards More Predictive, Physiological and Animal-free In Vitro Models: Advances in Cell and Tissue Culture 2020 Conference Proceedings

E. Budyn, Z. Ali, J. Connelly, 2021, Alternatives to laboratory animals : ATLA.

Nanoparticle Targeting to Scalp Hair Follicles - New Perspectives for a Topical Therapy of Alopecia Areata.

T. Vogt, C. Lehr, B. Loretz, 2019, The Journal of investigative dermatology.

Penetration of topically applied nanocarriers into the hair follicles of dog and rat dorsal skin and porcine ear skin.

A. Gruber, M. Darvin, C. Lehr, 2016, Veterinary dermatology.

Focused Ultrasound as a Scalable and Contact-Free Method to Manufacture Protein-Loaded PLGA Nanoparticles

C. Lehr, Marc Schneider, S. Schiller, 2015, Pharmaceutical Research.

Efficient nanoparticle-mediated needle-free transcutaneous vaccination via hair follicles requires adjuvantation.

T. Ebensen, K. Schulze, C. Guzmán, 2015, Nanomedicine : nanotechnology, biology, and medicine.

Transfollicular delivery takes root: the future for vaccine design?

C. Lehr, S. Hansen, 2014, Expert review of vaccines.

Particle based vaccine formulations for transcutaneous immunization

C. Lehr, A. Mittal, S. Hansen, 2013, Human vaccines & immunotherapeutics.

Design and in vitro characterization of multistage silicon-PLGA budesonide particles for inflammatory bowel disease.

M. Ferrari, B. Godin, S. Srinivasan, 2020, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Biodegradable microparticles as a two-drug controlled release formulation: a potential treatment of inflammatory bowel disease.

A. Lamprecht, C. Lehr, U. Schäfer, 2000, Journal of controlled release : official journal of the Controlled Release Society.

Embryonic Chicken Trachea as a New In Vitro Model for the Investigation of Mucociliary Particle Clearance in the Airways

C. Lehr, Marc Schneider, P. Gehr, 2008, AAPS PharmSciTech.

P-glycoprotein interactions of novel psychoactive substances - stimulation of ATP consumption and transport across Caco-2 monolayers.

M. Meyer, C. Lehr, B. Loretz, 2015, Biochemical pharmacology.

Preparation, characterisation and in vitro antibacterial property of ciprofloxacin-loaded nanostructured lipid carrier for treatment of Bacillus subtilis infection

M. Windbergs, C. Lehr, A. Attama, 2019, Journal of microencapsulation.

Testing of aerosolized ciprofloxacin nanocarriers on cystic fibrosis airway cells infected with P. aeruginosa biofilms

C. Lehr, Marc Schneider, C. de Souza Carvalho-Wodarz, 2021, Drug delivery and translational research.

In Vitro Model of the Gram-Negative Bacterial Cell Envelope for Investigation of Anti-Infective Permeation Kinetics.

R. Hartmann, F. Beckmann, C. Lehr, 2018, ACS infectious diseases.

Intracellular Dynamics of Extracellular Vesicles by Segmented Trajectory Analysis

C. Lehr, B. Loretz, E. Vuorimaa-Laukkanen, 2022, Analytical chemistry.

Farnesylated Glycol Chitosan as a Platform for Drug Delivery: Synthesis, Characterization, and Investigation of Mucus-Particle Interactions.

C. Lehr, B. Loretz, F. Lautenschläger, 2018, Biomacromolecules.

From the Structure of the Skin Barrier and Dermal Formulations to in vitro Transport Models for Skin Absorption: Skin Research in the Netherlands and in Germany

M. Windbergs, J. Bouwstra, C. Lehr, 2013, Skin Pharmacology and Physiology.

A foam model highlights the differences of the macro- and microrheology of respiratory horse mucus.

A. Gross, C. Lehr, Marc Schneider, 2017, Journal of the mechanical behavior of biomedical materials.

Influence of the application area on finite dose permeation in relation to drug type applied

Dirk Neumann, Dominik Selzer, Tsambika Hahn, 2012, Experimental dermatology.

Permeability of the reconstructed human epidermis model Episkin in comparison to various human skin preparations.

Claus-Michael Lehr, Ulrich F Schaefer, C. Lehr, 2007, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Streptococcal Extracellular Membrane Vesicles Are Rapidly Internalized by Immune Cells and Alter Their Cytokine Release

M. Koch, C. Lehr, G. Fuhrmann, 2020, Frontiers in Immunology.

Lipid–Polymer Hybrid Nanoparticles for mRNA Delivery to Dendritic Cells: Impact of Lipid Composition on Performance in Different Media

K. Schulze, C. Guzmán, C. Lehr, 2022, Pharmaceutics.

Wistar rat skin as surrogate for human skin in nortriptyline hydrochloride patch studies.

C. Lehr, U. Schäfer, A. Melero, 2010, International journal of pharmaceutics.

The effect of polymer size and charge of molecules on permeation through synovial membrane and accumulation in hyaline articular cartilage.

M. Windbergs, C. Lehr, S. Wöll, 2016, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Instrumented In Vitro Approaches to Assess Epithelial Permeability of Drugs from Pharmaceutical Formulations

C. Lehr, U. Schaefer, M. Bur, 2008 .

Spray-dried lactose-leucine microparticles for pulmonary delivery of antimycobacterial nanopharmaceuticals

C. Feldmann, C. Lehr, B. Loretz, 2021, Drug delivery and translational research.

Charge Modification of Pharmaceutical Nanocarriers: Biological Implications

C. Lehr, Marc Schneider, N. Nafee, 2008 .

Estimation of paracellular conductance of primary rat alveolar epithelial cell monolayers.

C. Ehrhardt, C. Lehr, B. Willis, 2005, Journal of applied physiology.

Triple co-culture of human alveolar epithelium, endothelium and macrophages for studying the interaction of nanocarriers with the air-blood barrier.

Claus-Michael Lehr, Bruno Sarmento, B. Sarmento, 2019, Acta biomaterialia.

P. aeruginosa Infected 3D Co-Culture of Bronchial Epithelial Cells and Macrophages at Air-Liquid Interface for Preclinical Evaluation of Anti-Infectives.

R. Bals, C. Beisswenger, T. Ebensen, 2020, Journal of visualized experiments : JoVE.

Cell culture models of biological barriers : in vitro test systems for drug absorption and delivery

Claus-Michael Lehr, C. Lehr, 2002 .

Influence of apical fluid volume on the development of functional intercellular junctions in the human epithelial cell line 16HBE14o–: implications for the use of this cell line as an in vitro model for bronchial drug absorption studies

Carsten Kneuer, Claus-Michael Lehr, Kwang-Jin Kim, 2002, Cell and Tissue Research.

An in vitro triple cell co-culture model with primary cells mimicking the human alveolar epithelial barrier.

Claus-Michael Lehr, Peter Gehr, B. Rothen‐Rutishauser, 2011, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Second-generation lung-on-a-chip array with a stretchable biological membrane

O. Guenat, T. Geiser, C. Lehr, 2019, bioRxiv.

Vibrational spectroscopic imaging and live cell video microscopy for studying differentiation of primary human alveolar epithelial cells

M. Windbergs, L. Gentile, T. Huser, 2019, Journal of biophotonics.

Isolation, cultivation, and application of human alveolar epithelial cells.

C. Lehr, H. Huwer, U. Schaefer, 2012, Methods in molecular biology.

Carrier systems for the treatment of inflammatory bowel disease

Y. Kawashima, A. Lamprecht, C. Lehr, 2002 .

Novel luminescence assay offers new possibilities for the risk assessment of silica nanoparticles

C. Lehr, N. Daum, H. Ohrem, 2008 .

Improved photostability and reduced skin permeation of tretinoin: development of a semisolid nanomedicine.

C. Lehr, K. Kostka, U. Schaefer, 2011, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Itaconic Acid Increases the Efficacy of Tobramycin against Pseudomonas aeruginosa Biofilms

C. Lehr, B. Loretz, X. Murgia, 2020, Pharmaceutics.

Online monitoring of transepithelial electrical resistance (TEER) in an apparatus for combined dissolution and permeation testing.

C. Lehr, U. Schaefer, S. Balbach, 2010, International journal of pharmaceutics.

In Situ Drug Release Monitoring with a Fiber-Optic System: Overcoming Matrix Interferences Using Derivative Spectrophotometry

C. Lehr, J. Krämer, A. Guillot, 2013 .

Cover Picture: Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and an Alkylquinolone Quorum Sensing Inhibitor Enable the Eradication of P. aeruginosa Biofilm Infections (Angew. Chem. Int. Ed. 26/2020)

R. Hartmann, P. Couvreur, R. Müller, 2020 .

Characterization and evaluation of β-glucan formulations as injectable implants for protein and peptide delivery

C. Lehr, I. Rupenthal, C. Bunt, 2012, Drug development and industrial pharmacy.

Synthesis and Biopharmaceutical Characterization of Amphiphilic Squalenyl Derivative Based Versatile Drug Delivery Platform

P. Couvreur, C. Lehr, B. Loretz, 2020, Frontiers in Chemistry.

Mucoadhesive properties of the mussel adhesive protein

C. Lehr, J. Schnurrer, 1996 .

FORCE MICROSCOPY OF CELLS TO MEASURE BIOADHESION

A. Plückthun, U. Hartmann, R. Ros, 1999 .

Atomic force microscopy and analytical ultracentrifugation for probing nanomaterial protein interactions.

Claus-Michael Lehr, Wendel Wohlleben, Christine Schulze, 2012, ACS nano.

Disease Models: Lung Models for Testing Drugs Against Inflammation and Infection.

C. Lehr, C. de Souza Carvalho-Wodarz, Patrick Carius, 2020, Handbook of experimental pharmacology.

Reoxygenation results in cell death of human alveolar epithelial cells.

H. Schäfers, M. Menger, C. Lehr, 2004, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Cationic silica nanoparticles as gene carriers: synthesis, characterization and transfection efficiency in vitro and in vivo.

R. Lockey, M. Sameti, U. Bakowsky, 2004, Journal of nanoscience and nanotechnology.

Dual flow bioreactor with ultrathin microporous TEER sensing membrane for evaluation of nanoparticle toxicity

Claus-Michael Lehr, Arti Ahluwalia, Tommaso Sbrana, 2016 .

Permeability assessment for solid oral drug formulations based on Caco-2 monolayer in combination with a flow through dissolution cell.

Claus-Michael Lehr, Thomas Eichinger, Ulrich F Schaefer, 2007, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Polysaccharide Submicrocarrier for Improved Pulmonary Delivery of Poorly Soluble Anti-infective Ciprofloxacin: Preparation, Characterization, and Influence of Size on Cellular Uptake.

C. Lehr, B. Loretz, C. de Souza Carvalho-Wodarz, 2018, Molecular pharmaceutics.

Nanoparticle geometry and surface orientation influence mode of cellular uptake.

A. Jones, H. Ghandehari, C. Lehr, 2013, ACS nano.

Laser ablation patterning by interference induces directional cell growth

U. Bakowsky, U. Bakowsky, C. Lehr, 2003, IEEE Transactions on NanoBioscience.

Cationic poly(lactide-co-glycolide) nanoparticles as efficient in vivo gene transfection agents.

U. Bakowsky, C. Lehr, S. Mohapatra, 2004, Journal of nanoscience and nanotechnology.

Propidium iodide labeling of nanoparticles as a novel tool for the quantification of cellular binding and uptake.

C. Lehr, M. Veith, N. Daum, 2011, Nanomedicine : nanotechnology, biology, and medicine.

Systemic Delivery of Cetrorelix to Rats by a New Aerosol Delivery System

G. Borchard, C. Lehr, R. Lizio, 2001, Pharmaceutical Research.

Multiphoton microscopy for the investigation of trans-cutaneous drug delivery

Karsten König, Frank Stracke, Marc Schneider, 2007, European Conference on Biomedical Optics.

Multilayer coating of gold nanoparticles with drug-polymer coadsorbates.

R. Hartmann, C. Lehr, Marc Schneider, 2010, Langmuir : the ACS journal of surfaces and colloids.

Yields and Immunomodulatory Effects of Pneumococcal Membrane Vesicles Differ with the Bacterial Growth Phase

D. Becher, C. Lehr, M. Koch, 2021, Advanced healthcare materials.

3D bioprinting of E. coli MG1655 biofilms on human lung epithelial cells for building complex in vitro infection models

C. Lehr, B. Loretz, D. Krug, 2023, Biofabrication.

Influence of agglomeration and specific lung lining lipid/protein interaction on short-term inhalation toxicity

Claus-Michael Lehr, Andreas Luch, Sarah Mues, 2016, Nanotoxicology.

Assessing transferrin modification of liposomes by atomic force microscopy and transmission electron microscopy.

C. Ehrhardt, U. Bakowsky, C. Lehr, 2005, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Pulmonary surfactant is indispensable in order to simulate the in vivo situation

W. Kreyling, C. Lehr, C. Schleh, 2013, Particle and Fibre Toxicology.

Safety of Nanomaterials along Their Lifecycle : Release, Exposure, and Human Hazards

Claus-Michael Lehr, Thomas A. J. Kuhlbusch, Wendel Wohlleben, 2014 .

From sticky stuff to sweet receptors — achievements, limits and novel approaches to bioadhesion

C. M. Lehr, C. Lehr, Claus-Michael Lehr, 1996, European Journal of Drug Metabolism and Pharmacokinetics.

Improved Oral Peptide Delivery by Means of Mucoadhesion

H. Junginger, J. Bouwstra, C. Lehr, 1990 .

Different macro- and micro-rheological properties of native porcine respiratory and intestinal mucus.

C. Lehr, Harish Bokkasam, U. Schaefer, 2016, International journal of pharmaceutics.

Erratum to: Scope and relevance of a pulmonary biopharmaceutical classification system AAPS/FDA/USP Workshop March 16-17th, 2015 in Baltimore, MD

W. Doub, M. Sakagami, C. Lehr, 2016 .

The buccal mucosa as a route for TiO2 nanoparticle uptake

A. Zimmer, G. Leitinger, C. Lehr, 2015, Nanotoxicology.

Dissolution Testing of Powders for Inhalation: Influence of Particle Deposition and Modeling of Dissolution Profiles

C. Lehr, Marc Schneider, M. Wolkenhauer, 2014, Pharmaceutical Research.

In Vitro–In Vivo Correlation: Shades on Some Non-Conventional Dosage Forms

C. Lehr, J. Krämer, Abdulwahab Barakat, 2015 .

Oral bioavailability of proteolytic enzymes

C. Lehr, P. Streichhan, C. Kolac, 1996 .

Modulating the Barrier Function of Human Alveolar Epithelial (hAELVi) Cell Monolayers as a Model of Inflammation

C. Lehr, N. Schneider-Daum, G. Croston, 2020, Alternatives to laboratory animals : ATLA.

Cell-Derived Vesicles for Antibiotic Delivery-Understanding the Challenges of a Biogenic Carrier System.

C. Lehr, B. Loretz, M. Koch, 2023, Small.

Leaky gut model of the human intestinal mucosa for testing siRNA-based nanomedicine targeting JAK1

X. Gidrol, D. Jary, C. Lehr, 2022, Journal of Controlled Release.

Development of A Flexible Cell Targeting System Based on Silica Nanoparticles

T. Schiestel, M. Sameti, G. Borchard, 1998 .

Absorption enhancement by lectin-mediated endo- and transcytosis.

G. Borchard, C. Lehr, E. Haltner, 1998, Methods in Molecular Medicine.

Semi-Automated Nanoprecipitation-System—An Option for Operator Independent, Scalable and Size Adjustable Nanoparticle Synthesis

C. Lehr, Marc Schneider, R. Rietscher, 2015, Pharmaceutical Research.

Towards a Continuous Manufacturing Process of Protein-Loaded Polymeric Nanoparticle Powders

C. Lehr, Marc Schneider, S. Schiller, 2020, AAPS PharmSciTech.

In vitro systems for studying epithelial transport of macromolecules.

C. Lehr, N. Daum, M. Bur, 2009, Methods in molecular biology.

Nanoscale Drugs: A Key to Revolutionary Progress in Pharmacy and Healthcare

C. Alexiou, C. Lehr, S. Raesch, 2016 .

Modeling the human skin barrier--towards a better understanding of dermal absorption.

Claus-Michael Lehr, Steffi Hansen, Ulrich F Schaefer, 2013, Advanced drug delivery reviews.

A Design of Experiment Study of Nanoprecipitation and Nano Spray Drying as Processes to Prepare PLGA Nano- and Microparticles with Defined Sizes and Size Distributions

F. D. Crecy, C. Lehr, S. Hansen, 2015, Pharmaceutical Research.

The Physicochemical Parameters of Marker Compounds and Vehicles for Use in In Vitro Percutaneous Absorption Studies

C. Lehr, C. Müller-Goymann, U. Schäfer, 2008, Alternatives to laboratory animals : ATLA.

Statistical Comparison of Dissolution Profiles to Predict the Bioequivalence of Extended Release Formulations

T. Lehr, C. Lehr, U. Schaefer, 2014, The AAPS Journal.

Nanomedicine for Drug Delivery across Epithelial Barriers: Intestines, Skin and Lungs

C. Lehr, 2010 .

Measuring Skin Absorption In Vitro

C. Lehr, T. Hahn, U. Schaefer, 2010 .

Towards nanotechnology regulation — Publish the unpublishable

Claus-Michael Lehr, Albert Duschl, Steve Hankin, 2011 .

Reconstructed skin equivalents for assessing percutaneous drug absorption from pharmaceutical formulations.

N. Zghoul, C. Lehr, U. Schaefer, 2001, ALTEX.

Mucociliary clearance of micro- and nanoparticles is independent of size, shape and charge--an ex vivo and in silico approach.

S. Mitragotri, Nishit Doshi, C. Lehr, 2012, Journal of controlled release : official journal of the Controlled Release Society.

Inhalable Clarithromycin Microparticles for Treatment of Respiratory Infections

R. Hartmann, C. Lehr, Jörg Haupenthal, 2015, Pharmaceutical Research.

A pulmonary mucus surrogate for investigating antibiotic permeation and activity against Pseudomonas aeruginosa biofilms.

C. Lehr, B. Loretz, C. de Souza Carvalho-Wodarz, 2021, The Journal of antimicrobial chemotherapy.

Computational fluid dynamics of nanoparticle disposition in the airways: mucus interactions and mucociliary clearance

Claus-Michael Lehr, Marco Günther, Marc Schneider, 2011, Comput. Vis. Sci..

Studying cellular binding and uptake of bioadhesive lectins

M. Wirth, C. Lehr, C. Kneuer, 2002 .

Functional Materials to Overcome Bacterial Barriers and Models to Advance Their Development

C. Lehr, B. Loretz, Glorjen Mulla, 2023, Advanced Functional Materials.

Solid Phase Extraction as an Innovative Separation Method for Measuring Free and Entrapped Drug in Lipid Nanoparticles

C. Lehr, A. Guillot, F. Navarro, 2015, Pharmaceutical Research.

Disrupting Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Latent Replication with a Small Molecule Inhibitor.

C. Lehr, B. Loretz, A. Hirsch, 2023, Journal of medicinal chemistry.

Nanoparticles made from novel starch derivatives for transdermal drug delivery.

M. J. Santander-Ortega, C. Lehr, B. Loretz, 2010, Journal of controlled release : official journal of the Controlled Release Society.

Development and evaluation of a quality control system based on transdermal electrical resistance for skin barrier function in vitro

C. Lehr, H. Smola, U. Bock, 2021, Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging.

Chemically modified hCFTR mRNAs recuperate lung function in a mouse model of cystic fibrosis

N. Pedemonte, C. Seitz, R. Handgretinger, 2018, Scientific Reports.

Budesonide Loaded PLGA Nanoparticles for Targeting the Inflamed Intestinal Mucosa—Pharmaceutical Characterization and Fluorescence Imaging

M. Windbergs, C. Lehr, B. Weigmann, 2016, Pharmaceutical Research.

The influence of physicochemical parameters on the efficacy of non-viral DNA transfection complexes: a comparative study.

C. Ehrhardt, V. Oberle, D. Hoekstra, 2006, Journal of Nanoscience and Nanotechnology.

Formulation of benznidazole-lipid nanocapsules: Drug release, permeability, biocompatibility, and stability studies.

C. Lehr, B. Loretz, G. Bastiat, 2023, International journal of pharmaceutics.

Crossing biological barriers for advanced drug delivery.

M. Windbergs, C. Lehr, B. Loretz, 2013, European journal of pharmaceutics and biopharmaceutics.

Role of Surfactant Proteins in the interaction of nanoparticles with the air-blood-barrier

C. Casals, C. Lehr, Marc Schneider, 2011 .

Study of beta-lactoglobulin/acacia gum complex coacervation by diffusing-wave spectroscopy and confocal scanning laser microscopy.

C. Sánchez, A. Lamprecht, C. Lehr, 2001, Colloids and Surfaces B: Biointerfaces.

Biopharmaceutical Characterization of the Telomerase Inhibitor BRACO19

U. Klotz, J. Mueller, C. Lehr, 2006, Pharmaceutical Research.

In vivo genome editing using nuclease-encoding mRNA corrects SP-B deficiency

S. Beer-Hammer, B. Nürnberg, M. Schwab, 2015, Nature Biotechnology.

Chemical-Modified mRNA Therapy for Cystic Fibrosis by Targeting Lung Cells

H. Wendel, A. K. M. Ashiqul Haque, Brian Weidensee, 2019, COPD: Journal of Chronic Obstructive Pulmonary Disease.

Overview of Inhaled Nanopharmaceuticals.

C. Lehr, B. Loretz, X. Murgia, 2023, Journal of aerosol medicine and pulmonary drug delivery.

Modified hCFTR mRNA restores normal lung function in a mouse model of cystic fibrosis

N. Pedemonte, C. Seitz, R. Handgretinger, 2017, bioRxiv.

in pulmonary

C. Lehr, B. Loretz, U. Schaefer, 2021 .

Nano- and microscaled particles for drug targeting to inflamed intestinal mucosa: a first in vivo study in human patients.

J. Schulzke, C. Lehr, A. Stallmach, 2013, Journal of controlled release : official journal of the Controlled Release Society.

The influence of chitosan content in cationic chitosan/PLGA nanoparticles on the delivery efficiency of antisense 2'-O-methyl-RNA directed against telomerase in lung cancer cells.

U. Klotz, C. Lehr, H. Huwer, 2009, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Decomposition of the telomere-targeting agent BRACO19 in physiological media results in products with decreased inhibitory potential.

U. Klotz, C. Lehr, U. Schaefer, 2008, International journal of pharmaceutics.

Human vascular endothelial cells in primary cell culture for the evaluation of nanoparticle bioadhesion.

Claus-Michael Lehr, Dirk Neumann, Alf Lamprecht, 2006, Journal of nanoscience and nanotechnology.

Mono- and Cocultures of Bronchial and Alveolar Epithelial Cells Respond Differently to Proinflammatory Stimuli and Their Modulation by Salbutamol and Budesonide.

C. Lehr, H. Huwer, P. Young, 2015, Molecular pharmaceutics.

Transfection system of amino-functionalized calcium phosphate nanoparticles: in vitro efficacy, biodegradability, and immunogenicity study.

Babak Mostaghaci, G. Kickelbick, Julia Susewind, 2015, ACS applied materials & interfaces.

Preparation of Co-Amorphous Levofloxacin Systems for Pulmonary Application

C. Lehr, H. Grohganz, Aljoscha Gabelmann, 2023, Pharmaceutics.

Adhesion Molecule‐Modified Cardiovascular Prostheses: Characterization of Cellular Adhesion in a Cell Culture Model and by Cellular Force Spectroscopy

D. Jahn, C. Ehrhardt, D. Hoekstra, 2006 .

Development of a fluorescence-based assay for screening of modulators of human organic anion transporter 1B3 (OATP1B3).

O. Kohlbacher, Hans-Peter Lenhof, C. Lehr, 2006, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Simulated Tempering-Enhanced Umbrella Sampling Improves Convergence of Free Energy Calculations of Drug Membrane Permeation.

J. Hub, C. Lehr, Robert A. Becker, 2023, Journal of chemical theory and computation.

Dissolution Testing of Powders for Inhalation: Influence of Particle Deposition and Modeling of Dissolution Profiles

Claus-Michael Lehr, Marc Schneider, C. Lehr, 2014, Pharmaceutical Research.

Inhibitors of the Elastase LasB for the Treatment of Pseudomonas aeruginosa Lung Infections

C. Beisswenger, C. Lehr, B. Loretz, 2023, ACS central science.

Optical tweezers reveal relationship between microstructure and nanoparticle penetration of pulmonary mucus

C. Lehr, Marc Schneider, U. Schaefer, 2012, Proceedings of the National Academy of Sciences.

Uptake of nanoparticles by alveolar macrophages is triggered by surfactant protein A.

C. Casals, C. Lehr, Marc Schneider, 2011, Nanomedicine : nanotechnology, biology, and medicine.

Different macro- and micro-rheological properties of native porcine respiratory and intestinal mucus.

C. Lehr, Harish Bokkasam, U. Schaefer, 2016, International journal of pharmaceutics.

Correction: The Interplay of Lung Surfactant Proteins and Lipids Assimilates the Macrophage Clearance of Nanoparticles

C. Casals, C. Lehr, J. Pérez-Gil, 2012, PLoS ONE.

Plant genetic factors for iron homeostasis affect iron bioavailability in Caco-2 cells

P. Bauer, C. Lehr, U. Schaefer, 2010 .

Enhanced cellular delivery of idarubicin by surface modification of propyl starch nanoparticles employing pteroic acid conjugated polyvinyl alcohol.

R. Jain, P. Dandekar, C. Lehr, 2011, International journal of pharmaceutics.

Multistage Vector for Controlled Oral Delivery of Anti-Inflammatory Drug in Inflammatory Bowel Disease Treatment

B. Godin, C. Lehr, F. Leonard, 2013 .

Cell culture models and nanobiotechnology--contemporary topics in advanced drug delivery research.

C. Lehr, 2005, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

pH-Responsive Dynaplexes as Potent Apoptosis Inductors by Intracellular Delivery of Survivin siRNA.

C. Lehr, B. Loretz, Sangeun Lee, 2023, Biomacromolecules.

Improved ocular penetration of gentamicin by mucoadhesive polymer polycarbophil in the pigmented rabbit.

V. H. Lee, C. Lehr, C. Lehr, 1994, Investigative ophthalmology & visual science.