T. Ishii

发表

Optimized rod length of polyplex micelles for maximizing transfection efficiency and their performance in systemic gene therapy against stroma-rich pancreatic tumors.

K. Kataoka, K. Itaka, S. Uchida, 2014, Biomaterials.

Multifunctional polyion complex micelle featuring enhanced stability, targetability, and endosome escapability for systemic siRNA delivery to subcutaneous model of lung cancer

K. Toh, Y. Matsumoto, N. Nishiyama, 2013, Drug Delivery and Translational Research.

Enhanced stability and gene silencing ability of siRNA-loaded polyion complexes formulated from polyaspartamide derivatives with a repetitive array of amino groups in the side chain.

N. Nishiyama, K. Kataoka, K. Itaka, 2012, Biomaterials.

Odd-even effect of repeating aminoethylene units in the side chain of N-substituted polyaspartamides on gene transfection profiles.

Kazunori Kataoka, Nobuhiro Nishiyama, Keiji Itaka, 2011, Journal of the American Chemical Society.

Biodegradable polyamino acid-based polycations as safe and effective gene carrier minimizing cumulative toxicity.

K. Kataoka, K. Itaka, T. Ishii, 2010, Biomaterials.

Charge-conversion ternary polyplex with endosome disruption moiety: a technique for efficient and safe gene delivery.

Kazunori Kataoka, Nobuhiro Nishiyama, Kanjiro Miyata, 2008, Angewandte Chemie.

Dual environment-responsive polyplex carriers for enhanced intracellular delivery of plasmid DNA.

N. Nishiyama, K. Kataoka, K. Miyata, 2012, Biomacromolecules.

Polyplex micelles prepared from ω-cholesteryl PEG-polycation block copolymers for systemic gene delivery.

S. Fukushima, M. Kano, N. Nishiyama, 2011, Biomaterials.

Combination of chondroitin sulfate and polyplex micelles from Poly(ethylene glycol)-poly{N'-[N-(2-aminoethyl)-2-aminoethyl]aspartamide} block copolymer for prolonged in vivo gene transfection with reduced toxicity.

K. Kataoka, K. Itaka, S. Uchida, 2011, Journal of controlled release : official journal of the Controlled Release Society.

Efficient delivery of bioactive antibodies into the cytoplasm of living cells by charge-conversional polyion complex micelles.

N. Nishiyama, K. Kataoka, K. Itaka, 2010, Angewandte Chemie.

Polyion complex stability and gene silencing efficiency with a siRNA-grafted polymer delivery system.

N. Nishiyama, K. Kataoka, Y. Yamasaki, 2010, Biomaterials.

In Vivo Messenger RNA Introduction into the Central Nervous System Using Polyplex Nanomicelle

S. Fukushima, K. Kataoka, K. Itaka, 2013, PloS one.

A protein nanocarrier from charge-conversion polymer in response to endosomal pH.

Kazunori Kataoka, S. Fukushima, K. Kataoka, 2007, Journal of the American Chemical Society.

Glucose transporter 1‐mediated vascular translocation of nanomedicines enhances accumulation and efficacy in solid tumors

H. Saya, O. Nagano, Y. Anraku, 2019, Journal of controlled release : official journal of the Controlled Release Society.

One-Pot Synthesis of pH-Responsive PEGylated Nanogels Containing Gold Nanoparticles by Autoreduction of Chloroaurate Ions within Nanoreactors

Y. Nagasaki, T. Ishii, M. Oishi, 2007 .

cRGD peptide‐installed epirubicin‐loaded polymeric micelles for effective targeted therapy against brain tumors

N. Nishiyama, K. Kataoka, H. Cabral, 2017, Journal of controlled release : official journal of the Controlled Release Society.

Charge-conversional polyionic complex micelles-efficient nanocarriers for protein delivery into cytoplasm.

N. Nishiyama, K. Kataoka, Yan Lee, 2009, Angewandte Chemie.

pDNA/poly(L-lysine) Polyplexes Functionalized with a pH-Sensitive Charge-Conversional Poly(aspartamide) Derivative for Controlled Gene Delivery to Human Umbilical Vein Endothelial Cells.

K. Kataoka, Yan Lee, K. Miyata, 2010, Macromolecular rapid communications.

Smart PEGylated Gold Nanoparticles for the Cytoplasmic Delivery of siRNA to Induce Enhanced Gene Silencing

Yukio Nagasaki, Y. Nagasaki, T. Ishii, 2006 .

Impact of polyplex micelles installed with cyclic RGD peptide as ligand on gene delivery to vascular lesions

T. Shimada, K. Kataoka, T. Takato, 2011, Gene Therapy.

Acidic pH-responsive siRNA conjugate for reversible carrier stability and accelerated endosomal escape with reduced IFNα-associated immune response.

N. Nishiyama, K. Kataoka, S. Uchida, 2013, Angewandte Chemie.

Development of Biodegradable Polycation-Based Inhalable Dry Gene Powders by Spray Freeze Drying

K. Kataoka, Yuko Kobayashi, K. Itaka, 2015, Pharmaceutics.

Systemic delivery of messenger RNA for the treatment of pancreatic cancer using polyplex nanomicelles with a cholesterol moiety.

K. Kataoka, K. Itaka, S. Uchida, 2016, Biomaterials.

Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors.

Takahiro Nomoto, K. Toh, Y. Matsumoto, 2014, Biomaterials.

Smart multilayered assembly for biocompatible siRNA delivery featuring dissolvable silica, endosome-disrupting polycation, and detachable PEG.

Y. Anraku, N. Nishiyama, K. Kataoka, 2012, ACS nano.

Gene Transfection toward Spheroid Cells on Micropatterned Culture Plates for Genetically-modified Cell Transplantation.

K. Kataoka, K. Itaka, S. Uchida, 2015, Journal of visualized experiments : JoVE.

Messenger RNA-based therapeutics for the treatment of apoptosis-associated diseases

K. Kataoka, K. Itaka, S. Uchida, 2015, Scientific Reports.

Recombination process of CdS quantum dot covered by novel polymer chains

I. Umezu, Y. Nagasaki, T. Ishii, 2004 .

Polymer–metal complex micelles for the combination of sustained drug releasing and photodynamic therapy

Kang Wang, T. Ishii, W. Jang, 2009 .

Accelerated polymer-polymer click conjugation by freeze-thaw treatment.

N. Nishiyama, K. Kataoka, K. Miyata, 2012, Bioconjugate chemistry.

Intratracheal gene transfer of adrenomedullin using polyplex nanomicelles attenuates monocrotaline-induced pulmonary hypertension in rats.

N. Nishiyama, K. Kataoka, K. Itaka, 2009, Molecular therapy : the journal of the American Society of Gene Therapy.

Polyplex Micelles with Double-Protective Compartments of Hydrophilic Shell and Thermoswitchable Palisade of Poly(oxazoline)-Based Block Copolymers for Promoted Gene Transfection.

K. Kataoka, K. Osada, A. Dirisala, 2016, Biomacromolecules.

Optical properties of CdS nanocrystal covered by polymer chains on the surface

I. Umezu, Y. Nagasaki, T. Ishii, 2003 .

Intracellular Delivery of Charge-Converted Monoclonal Antibodies by Combinatorial Design of Block/Homo Polyion Complex Micelles.

N. Nishiyama, K. Kataoka, H. Cabral, 2016, Biomacromolecules.

Novel molecular recognition via fluorescent resonance energy transfer using a biotin-PEG/polyamine stabilized CdS quantum dot.

K. Kataoka, H. Otsuka, Y. Nagasaki, 2004, Langmuir : the ACS journal of surfaces and colloids.

Polyplex Micelles with Phenylboronate/Gluconamide Cross-Linking in the Core Exerting Promoted Gene Transfection through Spatiotemporal Responsivity to Intracellular pH and ATP Concentration.

K. Kataoka, S. Uchida, H. Cabral, 2017, Journal of the American Chemical Society.

Innentitelbild: A Synthetic Approach Toward a Self‐Regulated Insulin Delivery System (Angew. Chem. 9/2012)

Y. Miyahara, K. Kataoka, T. Ishii, 2012 .

New Synthesis of Heterobifunctional Poly(ethylene glycol) Possessing a Pyridyl Disulfide at One End and a Carboxylic Acid at the Other End

Y. Nagasaki, T. Ishii, Masayoshi Yamada, 2005 .

Phenylboronic acid-installed polymeric micelles for targeting sialylated epitopes in solid tumors.

Y. Miyahara, N. Nishiyama, K. Kataoka, 2013, Journal of the American Chemical Society.

PEGylated Calcium Phosphate Nanocomposites as Smart Environment‐Sensitive Carriers for siRNA Delivery

Yuichi Yamasaki, Kazunori Kataoka, Nobuhiro Nishiyama, 2009 .

Homo-catiomer integration into PEGylated polyplex micelle from block-catiomer for systemic anti-angiogenic gene therapy for fibrotic pancreatic tumors.

M. Kano, K. Kataoka, K. Itaka, 2012, Biomaterials.

Enhanced endosomal escape of siRNA-incorporating hybrid nanoparticles from calcium phosphate and PEG-block charge-conversional polymer for efficient gene knockdown with negligible cytotoxicity.

N. Nishiyama, K. Kataoka, Yan Lee, 2011, Biomaterials.

Preparation of functionally Pegylated gold nanoparticles with narrow distribution through autoreduction of auric cation by alpha-biotinyl-PEG-block-[poly(2- (N,N-dimethylamino)ethyl methacrylate)].

Kazunori Kataoka, Yukio Nagasaki, Hidenori Otsuka, 2004, Langmuir : the ACS journal of surfaces and colloids.

Selective intracellular delivery of proteasome inhibitors through pH-sensitive polymeric micelles directed to efficient antitumor therapy.

K. Toh, N. Nishiyama, K. Kataoka, 2014, Journal of controlled release : official journal of the Controlled Release Society.

Modulated protonation of side chain aminoethylene repeats in N-substituted polyaspartamides promotes mRNA transfection.

Takahiro Nomoto, N. Nishiyama, K. Kataoka, 2014, Journal of the American Chemical Society.

Effective transgene expression without toxicity by intraperitoneal administration of PEG-detachable polyplex micelles in mice with peritoneal dissemination.

N. Nishiyama, K. Kataoka, K. Itaka, 2012, Journal of controlled release : official journal of the Controlled Release Society.

Enhanced Intracellular Delivery of siRNA by Controlling ATP-Responsivity of Phenylboronic Acid-Functionalized Polyion Complex Micelles.

Y. Miyahara, K. Kataoka, K. Miyata, 2018, Macromolecular bioscience.

Muscle-targeted hydrodynamic gene introduction of insulin-like growth factor-1 using polyplex nanomicelle to treat peripheral nerve injury.

K. Kataoka, K. Itaka, S. Uchida, 2014, Journal of controlled release : official journal of the Controlled Release Society.

A phenylboronate-functionalized polyion complex micelle for ATP-triggered release of siRNA.

Akira Matsumoto, Yuji Miyahara, Kazunori Kataoka, 2012, Angewandte Chemie.

Synthetic Polyamines to Regulate mRNA Translation through the Preservative Binding of Eukaryotic Initiation Factor 4E to the Cap Structure.

N. Nishiyama, K. Kataoka, K. Itaka, 2016, Journal of the American Chemical Society.

The initiatives for regulatory science researches of nanomedicines

Yasuhiro Matsumura, Kazunori Kataoka, Harashima Hideyoshi, 2014 .

Copolymers including L-histidine and hydrophobic moiety for preparation of nonbiofouling surface.

M. Casolaro, Yoshihiro Ito, T. Ishii, 2007, Biomacromolecules.

A synthetic approach toward a self-regulated insulin delivery system.

Akira Matsumoto, Yuji Miyahara, Kazunori Kataoka, 2012, Angewandte Chemie.

An injectable spheroid system with genetic modification for cell transplantation therapy.

Yu Matsumoto, Satoshi Uchida, Kazunori Kataoka, 2014, Biomaterials.

Gene Transfer Using Micellar Nanovectors Inhibits Choroidal Neovascularization In Vivo

N. Nishiyama, K. Kataoka, M. Oba, 2011, PloS one.

PEGylated polyplex with optimized PEG shielding enhances gene introduction in lungs by minimizing inflammatory responses.

K. Kataoka, K. Itaka, S. Uchida, 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

PEG-detachable polyplex micelles based on disulfide-linked block catiomers as bioresponsive nonviral gene vectors.

Yuichi Yamasaki, Kazunori Kataoka, Nobuhiro Nishiyama, 2008, Journal of the American Chemical Society.

Multifunctional polyion complex micelle featuring enhanced stability, targetability, and endosome escapability for systemic siRNA delivery to subcutaneous model of lung cancer

K. Toh, Y. Matsumoto, N. Nishiyama, 2014, Drug Delivery and Translational Research.

Multilayered polyion complexes with dissolvable silica layer covered by controlling densities of cRGD-conjugated PEG chains for cancer-targeted siRNA delivery

N. Nishiyama, K. Kataoka, K. Miyata, 2017, Journal of biomaterials science. Polymer edition.

Enhanced target recognition of nanoparticles by cocktail PEGylation with chains of varying lengths.

Y. Anraku, K. Kataoka, K. Miyata, 2016, Chemical communications.

Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain

Y. Anraku, K. Toh, Y. Matsumoto, 2017, Nature Communications.