Gu He

Xiangrong Song, Gu He, Zheng Cai, 2009, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Asymmetric synthesis of tetrahydroisoquinoline-fused spirooxindoles as Ras-GTP inhibitors that inhibit colon adenocarcinoma cell proliferation and invasion.

Gu He, Bo Han, Cheng Peng, 2018, Chemical communications.

Organocatalytic Asymmetric Synthesis of Spiro-oxindole Piperidine Derivatives That Reduce Cancer Cell Proliferation by Inhibiting MDM2-p53 Interaction.

Gu He, Lei Yang, Bo Han, 2017, Organic letters.

Recent development of poly(ethylene glycol)-cholesterol conjugates as drug delivery systems.

Z. Qian, Zhi-Yao He, Xia-Wei Wei, 2014, International journal of pharmaceutics.

Analysis of furo[3,2-c]tetrahydroquinoline and pyrano[3,2-c]tetrahydroquinoline derivatives as antitumor agents and their metabolites by liquid chromatography/electrospray ionization tandem mass spectrometry.

Gu He, Meng Zhou, Hao Luo, 2013, Rapid communications in mass spectrometry : RCM.

Cell and in vivo imaging of fluoride ion with highly selective bioluminescent probes.

Gu He, Minyong Li, Wenxiao Wu, 2015, Analytical chemistry.

Application of organocatalysis in bioorganometallic chemistry: asymmetric synthesis of multifunctionalized spirocyclic pyrazolone–ferrocene hybrids as novel RalA inhibitors

Gu He, Bo Han, Cheng Peng, 2018 .

Development of glycyrrhetinic acid-modified stealth cationic liposomes for gene delivery.

Zhi-Yao He, Gu He, S. Mao, 2010, International journal of pharmaceutics.

Development of PLGA nanoparticles simultaneously loaded with vincristine and verapamil for treatment of hepatocellular carcinoma.

Li Yang, Li Yang, Xiangrong Song, 2010, Journal of pharmaceutical sciences.

Facile Construction of Chloroquine Containing PLGA-Based pDNA Delivery System for Efficient Tumor and Pancreatitis Targeting in Vitro and in Vivo.

Z. Qian, A. Tong, G. Guo, 2015, Molecular pharmaceutics.

Discovery of spirooxindole-derived small-molecule compounds as novel HDAC/MDM2 dual inhibitors and investigation of their anticancer activity

Gu He, Cheng Peng, Xin‐Miao Xie, 2022, Frontiers in Oncology.

Synthesis, Characterization and In Vitro Evaluation of Self-Assembled poly(ethylene glycol)-glycyrrhetinic Acid Conjugates

L. Ouyang, Zhiyao He, Gu He, 2012 .

Receptor-mediated gene delivery by folate-poly(ethylene glycol)-grafted-trimethyl chitosan in vitro

Xiangrong Song, Gu He, Shixiang Hou, 2011, Journal of drug targeting.

Glycyrrhetinic Acid-Poly(ethylene glycol)-glycyrrhetinic Acid Tri-Block Conjugates Based Self-Assembled Micelles for Hepatic Targeted Delivery of Poorly Water Soluble Drug

Xiangrong Song, Gu He, Ting Xu, 2013, TheScientificWorldJournal.

Gastroprotective effects of several H2RAs on ibuprofen-induced gastric ulcer in rats.

Dan Sun, A. Tong, G. Guo, 2016, Life sciences.

Design, synthesis and biological evaluation of enzymatically cleavable NSAIDs prodrugs derived from self-immolative dendritic scaffolds for the treatment of inflammatory diseases.

L. Ouyang, Rui Zhou, Gu He, 2013, Bioorganic & medicinal chemistry.

Development of a novel biocompatible poly(ethylene glycol)-block-poly(γ-cholesterol-L-glutamate) as hydrophobic drug carrier.

Xiangrong Song, Qing-ping Ma, Gu He, 2013, International journal of pharmaceutics.

Development of inclusion complex of brinzolamide with hydroxypropyl-β-cyclodextrin.

Ying Zhang, Xiangrong Song, Zhiyao He, 2013, Carbohydrate polymers.

Folate-linked lipoplexes for short hairpin RNA targeting claudin-3 delivery in ovarian cancer xenografts.

X. Liang, Xia Zhao, Zhi-Yao He, 2013, Journal of controlled release : official journal of the Controlled Release Society.

Design, synthesis and biological evaluation of 4-aniline-thieno[2,3-d]pyrimidine derivatives as MNK1 inhibitors against renal cell carcinoma and nasopharyngeal carcinoma.

Gu He, Qinglin Jiang, Ming-li He, 2019, Bioorganic & medicinal chemistry.

Amine-catalyzed and functional group-controlled chemo- and regioselective synthesis of multi-functionalized CF3-benzene via a metal-free process

Gu He, Bo Han, Wei Huang, 2019, Green Chemistry.

Asymmetric Synthesis of Cyclohexane-Fused Drug-Like Spirocyclic Scaffolds Containing Six Contiguous Stereogenic Centers via Organocatalytic Cascade Reactions

Gu He, Jin-hui Wang, Bo Han, 2015 .

Asymmetric synthesis of a structurally and stereochemically complex spirooxindole pyran scaffold through an organocatalytic multicomponent cascade reaction.

Gu He, Bo Han, Cheng Peng, 2012, Chemical communications.

Design and synthesis of novel spirooxindole–indenoquinoxaline derivatives as novel tryptophanyl-tRNA synthetase inhibitors

Gu He, Youfu Luo, Wei Huang, 2019, Molecular Diversity.

Discovery of spirooxindole–ferrocene hybrids as novel MDM2 inhibitors

Gu He, Wei Huang, Xin‐Miao Xie, 2021 .

Rational drug design, synthesis, and biological evaluation of novel chiral tetrahydronaphthalene-fused spirooxindole as MDM2-CDK4 dual inhibitor against glioblastoma

N. Zhang, Gu He, Jin Zhou, 2019, Acta pharmaceutica Sinica. B.

Control of Activation Mode To Achieve Diastereodivergence in Asymmetric Syntheses of Chiral Spiropiperidinone Derivatives.

Gu He, Bo Han, Cheng Peng, 2017, The Journal of organic chemistry.

Organocatalytic cascade reaction for the asymmetric synthesis of novel chroman-fused spirooxindoles that potently inhibit cancer cell proliferation.

Qinjie Wu, Rui Zhou, Gu He, 2015, Chemical communications.

Asymmetric Synthesis of Cyclohexane‐Fused Drug‐Like Spirocyclic Scaffolds Containing Six Contiguous Stereogenic Centers via Organocatalytic Cascade Reactions.

Gu He, Jin-hui Wang, Bo Han, 2015 .

Organocatalytic tandem Morita-Baylis-Hillman-Michael reaction for asymmetric synthesis of a drug-like oxa-spirocyclic indanone scaffold.

L. Ouyang, Gu He, Lei Yang, 2013, Chemical communications.

Synthesis of novel spirooxindolo-pyrrolidines, pyrrolizidines, and pyrrolothiazoles via a regioselective three-component [3+2] cycloaddition and their preliminary antimicrobial evaluation

L. Ouyang, Shi Zeng, Gu He, 2013, Molecular Diversity.

Unconventional [2 + 3] Cyclization Involving [1,4]-Sulfonyl Transfer to Construct Polysubstituted Fluorazones as Inhibitors of Indoleamine 2,3-Dioxygenase 1.

Nan Zhang, Gu He, Bo Han, 2020, Organic letters.

Asymmetric organocatalysis: an enabling technology for medicinal chemistry.

Gu He, Bo Han, Cheng Peng, 2021, Chemical Society reviews.

Synthesis of novel spirooxindolo-pyrrolidines, pyrrolizidines, and pyrrolothiazoles via a regioselective three-component [3+2] cycloaddition and their preliminary antimicrobial evaluation

L. Ouyang, Shi Zeng, Gu He, 2013, Molecular Diversity.

Stereoselective Synthesis of Hydropyrano[3,2‐b]indoles via Organocatalytic Asymmetric Inverse‐Electron‐Demand Oxa‐Diels–Alder Reaction

Gu He, Bo Han, Cheng Peng, 2016 .

Discovery of hybrids of indolin-2-one and nitroimidazole as potent inhibitors against drug-resistant bacteria

Gu He, Yang Yang, Yuanzheng Zhou, 2018, The Journal of Antibiotics.

SYNTHESIS OF CIS OR TRANS 4-HETEROAROMATIC SUBSTITUTED FURANO AND PYRANO[3,2-c]TETRAHYDROQUINOLINES BY ONE-POT IMINO DIELS-ALDER REACTIONS

L. Ouyang, Xiangrong Song, Rui Zhou, 2013 .

Synthesis and theoretical study of first generation CCK-functional dendrimers

Gu He, Li Guo, 2007 .

Diastereoselective Three-Component Reactions of Chiral Nickel(II) Glycinate for Convenient Synthesis of Novel α-Amino-β-Substituted-γ,γ-Disubstituted Butyric Acids

L. Ouyang, Rui Zhou, Gu He, 2014, Molecules.

Preparation, antibacterial evaluation and preliminary structure-activity relationship (SAR) study of benzothiazol- and benzoxazol-2-amine derivatives.

Yuquan Wei, L. Ouyang, Gu He, 2012, Bioorganic & medicinal chemistry letters.

Indole Alkaloids from Chaetomium globosum.

Guo-lin Zhang, Gu He, Huan-Huan Bai, 2015, Journal of natural products.

Discovery of (Z)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione, a readily available and orally active glitazone for the treatment of concanavalin A-induced acute liver injury of BALB/c mice.

Yuquan Wei, Sheng-yong Yang, Gu He, 2010, Journal of medicinal chemistry.

Selective bone targeting 5-fluorouracil prodrugs: synthesis and preliminary biological evaluation.

L. Ouyang, B. Jiang, Zhengjun Chen, 2011, Bioorganic & medicinal chemistry.

Comparative study of (Asp)7-CHOL-modified liposome prepared using pre-insertion and post-insertion methods for bone targeting in vivo

A. Tong, G. Guo, Xiangrong Song, 2017, Journal of drug targeting.

LHD-Modified Mechanism-Based Liposome Coencapsulation of Mitoxantrone and Prednisolone Using Novel Lipid Bilayer Fusion for Tissue-Specific Colocalization and Synergistic Antitumor Effects.

C. Gong, A. Tong, G. Guo, 2016, ACS applied materials & interfaces.

Discovery of thieno[2,3-d]pyrimidine based hydroxamic acid derivatives as bromodomain-containing protein 4/histone deacetylases dual inhibitors induce autophagic cell death in colorectal carcinoma cells.

Xiang Li, N. Zhang, Gu He, 2020, Journal of medicinal chemistry.

Aconitine induces cardiomyocyte damage by mitigating BNIP3‐dependent mitophagy and the TNFα‐NLRP3 signalling axis

N. Zhang, Gu He, Bo Han, 2019, Cell proliferation.

Discovery of Novel Focal Adhesion Kinase Inhibitors Using a Hybrid Protocol of Virtual Screening Approach Based on Multicomplex-Based Pharmacophore and Molecular Docking

Cheng Peng, Ting Xu, Liang Ouyang, 2012, International journal of molecular sciences.

Enhanced antitumor activity and mechanism of biodegradable polymeric micelles-encapsulated chetomin in both transgenic zebrafish and mouse models.

Ling Li, Qinjie Wu, Yuquan Wei, 2014, Nanoscale.

Micelles based on methoxy poly(ethylene glycol)-cholesterol conjugate for controlled and targeted drug delivery of a poorly water soluble drug.

Xiangrong Song, Qing-ping Ma, Zhiyao He, 2012, Journal of biomedical nanotechnology.

Antitumor effects of MsurvivinT34A–CaPi complex-embedded PLGA nanoparticles in combination with Doxil in mice

Jie Tang, G. Guo, Xiangrong Song, 2014, Journal of Nanoparticle Research.

Synthesis, Characterization, and Evaluation of a Novel Amphiphilic Polymer RGD-PEG-Chol for Target Drug Delivery System

Shi Zeng, Gu He, Cheng Peng, 2014, TheScientificWorldJournal.

Diastereoselective Three-Component Reactions of Chiral Nickel(II) Glycinate for Convenient Synthesis of Novel alpha-Amino-beta-Substituted-gamma,gamma-Disubstituted Butyric Acids

L. Ouyang, Rui Zhou, Gu He, 2014 .

Discovery and in Vivo Evaluation of Novel RGD-Modified Lipid-Polymer Hybrid Nanoparticles for Targeted Drug Delivery

L. Ouyang, Gu He, Dayong Lin, 2014, International journal of molecular sciences.

Combined structure-based pharmacophore, virtual screening, and 3D-QSAR studies of structural diverse dehydrosqualene synthase inhibitors

Gu He, Mingli Xiang, Tao Yang, 2013, Medicinal Chemistry Research.

A novel truncated basic fibroblast growth factor fragment-conjugated poly (ethylene glycol)-cholesterol amphiphilic polymeric drug delivery system for targeting to the FGFR-overexpressing tumor cells.

Yuquan Wei, Xia Li, Li Yang, 2011, International journal of pharmaceutics.

Gene delivery with active targeting to ovarian cancer cells mediated by folate receptor alpha.

Zhiyao He, Gu He, J. He, 2013, Journal of biomedical nanotechnology.

Combined Structure-Based Pharmacophore and 3D-QSAR Studies on Phenylalanine Series Compounds as TPH1 Inhibitors

Wei Huang, Liang Ouyang, Gu He, 2012, International journal of molecular sciences.

Discovery of a self-assembling and self-adjuvant lipopeptide as a saccharide-free peptide vaccine targeting EGFRvIII positive cutaneous melanoma.

C. Gong, Gu He, Li Yang, 2018, Biomaterials science.

Improving the pharmacokinetics and tissue distribution of pyrinezolid by self-assembled polymeric micelles.

Lan Mei, G. Guo, Xiaoling Li, 2017, Colloids and surfaces. B, Biointerfaces.

Design and organocatalytic synthesis of spirooxindole–cyclopentene–isoxazole hybrids as novel MDM2–p53 inhibitors

Gu He, Bo Han, Cheng Peng, 2021 .

Organo/Silver Dual Catalytic (3 + 2)/Conia-Ene Type Cyclization: Asymmetric Synthesis of Indane-Fused Spirocyclopenteneoxindoles.

Gu He, Bo Han, Cheng Peng, 2022, Organic Letters.

Organocatalytic asymmetric synthesis of multifunctionalized α-carboline-spirooxindole hybrids that suppressed proliferation in colorectal cancer cells

Gu He, Bo Han, Cheng Peng, 2022, Organic Chemistry Frontiers.

Silver/chiral pyrrolidinopyridine relay catalytic cycloisomerization/(2 + 3) cycloadditions of enynamides to asymmetrically synthesize bispirocyclopentenes as PDE1B inhibitors

Y. Li, Gu He, Bo Han, 2023, Communications chemistry.

Design, Synthesis, and Biological Evaluation of Pyrano[2,3-c]-pyrazole–Based RalA Inhibitors Against Hepatocellular Carcinoma

Gu He, Qinglin Jiang, Cheng Peng, 2021, Frontiers in Chemistry.

Combining structure-based pharmacophore modeling, virtual screening, and in silico ADMET analysis to discover novel tetrahydro-quinoline based pyruvate kinase isozyme M2 activators with antitumor activity

Wei Huang, Cheng Peng, Liang Ouyang, 2014, Drug design, development and therapy.

Small-molecule dual inhibitors targeting heat shock protein 90 for cancer targeted therapy.

L. Foster, Gu He, Bo Han, 2023, Bioorganic chemistry.

Organocatalytic cascade reaction for the asymmetric synthesis of novel chroman-fused spirooxindoles that potently inhibit cancer cell proliferation.

Qinjie Wu, Rui Zhou, Gu He, 2015, Chemical communications.

Synthesis and characterization of a novel methoxy poly(ethylene glycol)-Tat peptide-chitosan copolymers

Qing-ping Ma, Shi Zeng, Gu He, 2013, Colloid and Polymer Science.

Gu He, Meng Zhou, Hao Luo, 2013, Rapid communications in mass spectrometry : RCM.