S. Muro

发表

Targeting, Endocytosis, and Lysosomal Delivery of Active Enzymes to Model Human Neurons by ICAM-1-Targeted Nanocarriers

J. Hoenicka, Janet Hsu, S. Muro, 2014, Pharmaceutical Research.

Strategies for delivery of therapeutics into the central nervous system for treatment of lysosomal storage disorders

Silvia Muro, S. Muro, 2012, Drug Delivery and Translational Research.

Effect of flow on endothelial endocytosis of nanocarriers targeted to ICAM-1.

Silvia Muro, Vladimir R Muzykantov, V. Muzykantov, 2012, Journal of controlled release : official journal of the Controlled Release Society.

Intracellular Delivery of Active Proteins by Polyphosphazene Polymers

T. Fuerst, S. Muro, Melani A Solomon, 2021, Pharmaceutics.

Lysosomal enzyme replacement therapies: Historical development, clinical outcomes, and future perspectives

S. Muro, Melani A Solomon, Melani A. Solomon, 2017, Advanced drug delivery reviews.

Combination-targeting to multiple endothelial cell adhesion molecules modulates binding, endocytosis, and in vivo biodistribution of drug nanocarriers and their therapeutic cargoes.

Janet Hsu, S. Muro, Z. Tsinas, 2014, Journal of controlled release : official journal of the Controlled Release Society.

How Carrier Size and Valency Modulate Receptor-Mediated Signaling: Understanding the Link between Binding and Endocytosis of ICAM-1-Targeted Carriers.

S. Muro, R. L. Manthe, D. Serrano, 2016, Biomacromolecules.

Flow shear stress differentially regulates endothelial uptake of nanocarriers targeted to distinct epitopes of PECAM-1.

V. Muzykantov, Jingyan Han, D. Eckmann, 2015, Journal of controlled release : official journal of the Controlled Release Society.

Design Parameters Modulating Intracellular Drug Delivery: Anchoring to Specific Cellular Epitopes, Carrier Geometry, and Use of Auxiliary Pharmacological Agents

V. Muzykantov, S. Muro, 2010 .

A novel endocytic pathway induced by clustering endothelial ICAM-1 or PECAM-1

V. Muzykantov, S. Albelda, S. Muro, 2003, Journal of Cell Science.

Slow intracellular trafficking of catalase nanoparticles targeted to ICAM-1 protects endothelial cells from oxidative stress.

V. Muzykantov, S. Muro, Michael Koval, 2003, American journal of physiology. Cell physiology.

Characterization of endothelial internalization and targeting of antibody-enzyme conjugates in cell cultures and in laboratory animals.

V. Muzykantov, S. Muro, J. Murciano, 2004, Methods in molecular biology.

Endothelial endocytic pathways: gates for vascular drug delivery.

V. Muzykantov, S. Muro, Michael Koval, 2004, Current vascular pharmacology.

Endothelial Targeting of High-Affinity Multivalent Polymer Nanocarriers Directed to Intercellular Adhesion Molecule 1

Silvia Muro, V. Muzykantov, S. Muro, 2006, Journal of Pharmacology and Experimental Therapeutics.

Control of intracellular trafficking of ICAM-1-targeted nanocarriers by endothelial Na+/H+ exchanger proteins.

V. Muzykantov, S. Muro, Michael Koval, 2006, American journal of physiology. Lung cellular and molecular physiology.

Differential intra-endothelial delivery of polymer nanocarriers targeted to distinct PECAM-1 epitopes.

V. Muzykantov, S. Albelda, S. Muro, 2008, Journal of controlled release : official journal of the Controlled Release Society.

Delivery of Acid Sphingomyelinase in Normal and Niemann-Pick Disease Mice Using Intercellular Adhesion Molecule-1-Targeted Polymer Nanocarriers

Silvia Muro, Vladimir Muzykantov, Eric Simone, 2008, Journal of Pharmacology and Experimental Therapeutics.

Enhanced endothelial delivery and biochemical effects of α-galactosidase by ICAM-1-targeted nanocarriers for Fabry disease.

Silvia Muro, T. Bhowmick, Janet Hsu, 2011, Journal of controlled release : official journal of the Controlled Release Society.

Optimizing endothelial targeting by modulating the antibody density and particle concentration of anti-ICAM coated carriers.

V. Muzykantov, D. Eckmann, T. Bhowmick, 2011, Journal of controlled release : official journal of the Controlled Release Society.

Enhanced delivery of α-glucosidase for Pompe disease by ICAM-1-targeted nanocarriers: comparative performance of a strategy for three distinct lysosomal storage disorders.

Silvia Muro, T. Bhowmick, Janet Hsu, 2012, Nanomedicine : nanotechnology, biology, and medicine.

Challenges in design and characterization of ligand-targeted drug delivery systems.

Silvia Muro, S. Muro, 2012, Journal of controlled release : official journal of the Controlled Release Society.

Endothelial targeting of polymeric nanoparticles stably labeled with the PET imaging radioisotope iodine-124.

Silvia Muro, Vladimir R Muzykantov, V. Muzykantov, 2012, Biomaterials.

In vivo performance of polymer nanocarriers dually-targeted to epitopes of the same or different receptors.

S. Muro, E. Schuchman, I. Papademetriou, 2013, Biomaterials.

Co-coating of receptor-targeted drug nanocarriers with anti-phagocytic moieties enhances specific tissue uptake versus non-specific phagocytic clearance.

Janet Hsu, S. Muro, Melani A Solomon, 2017, Biomaterials.

A Comparative Study on the Alterations of Endocytic Pathways in Multiple Lysosomal Storage Disorders.

S. Muro, Melani A Solomon, R. L. Manthe, 2016, Molecular pharmaceutics.

Induced Pluripotent Stem Cells for Disease Modeling and Evaluation of Therapeutics for Niemann-Pick Disease Type A

U. Baxa, Wei Zheng, J. Marugan, 2016, Stem cells translational medicine.

Combining vascular targeting and the local first pass provides 100‐fold higher uptake of ICAM‐1‐targeted vs untargeted nanocarriers in the inflamed brain

C. Villa, V. Muzykantov, C. Greineder, 2019, Journal of controlled release : official journal of the Controlled Release Society.

Open challenges in magnetic drug

I. Weinberg, P. Stepanov, S. Muro, 2014 .

Special Section on Drug Delivery Technologies d -Tocopherol Effect on Endocytosis and Its Combination with Enzyme Replacement Therapy for Lysosomal Disorders: A New Type of Drug Interaction? s

Wei Zheng, J. Marugan, D. Gugutkov, 2019 .

δ-Tocopherol Effect on Endocytosis and Its Combination with Enzyme Replacement Therapy for Lysosomal Disorders: A New Type of Drug Interaction?

Wei Zheng, J. Marugan, D. Gugutkov, 2019, The Journal of Pharmacology and Experimental Therapeutics.

ICAM-1 targeting, intracellular trafficking, and functional activity of polymer nanocarriers coated with a fibrinogen-derived peptide for lysosomal enzyme replacement

S. Muro, C. Garnacho, 2017, Journal of drug targeting.

Altered Clathrin-Independent Endocytosis in Type A Niemann-Pick Disease Cells and Rescue by ICAM-1-Targeted Enzyme Delivery.

S. Muro, R. L. Manthe, C. Garnacho, 2015, Molecular pharmaceutics.

Clathrin-Mediated Endocytosis Is Impaired in Type A–B Niemann–Pick Disease Model Cells and Can Be Restored by ICAM-1-Mediated Enzyme Replacement

S. Muro, C. Garnacho, J. Rappaport, 2014, Molecular pharmaceutics.

Enhancing biodistribution of therapeutic enzymes in vivo by modulating surface coating and concentration of ICAM-1-targeted nanocarriers.

J. Kao, T. Bhowmick, Janet Hsu, 2014, Journal of biomedical nanotechnology.

directed to ICAM-1

V. Muzykantov, S. Muro, T. Dziubla, 2006 .

Endothelial targeting of high-affinity multivalent polymer nanocarriers directed to ICAM-1

V. Muzykantov, S. Muro, J. Leferovich, 2006 .

endothelial luminal surface : Presented in part as posters at the ICAM-directed vascular immunotargeting of antithrombotic agents to the

V. Muzykantov, D. Cines, S. Albelda, 2013 .

endothelial luminal surface ICAM-directed vascular immunotargeting of anti-thrombotic agents to

V. Muzykantov, D. Cines, S. Albelda, 2003 .

Biodegradable "Smart" Polyphosphazenes with Intrinsic Multifunctionality as Intracellular Protein Delivery Vehicles.

T. Fuerst, S. Muro, A. Andrianov, 2017, Biomacromolecules.

Intertwined mechanisms define transport of anti-ICAM nanocarriers across the endothelium and brain delivery of a therapeutic enzyme.

T. Bhowmick, S. Muro, Melani A Solomon, 2020, Journal of controlled release : official journal of the Controlled Release Society.

Effect of thiol pendant conjugates on plasmid DNA binding, release, and stability of polymeric delivery vectors.

Michael S. Kang, P. Kofinas, S. Muro, 2012, Biomacromolecules.

Tuning Design Parameters of ICAM-1-Targeted 3DNA Nanocarriers to Optimize Pulmonary Targeting Depending on Drug Type

Jessica Bowers, R. Getts, S. Muro, 2022, Pharmaceutics.

Enhanced Delivery and Effects of Acid Sphingomyelinase by ICAM-1-Targeted Nanocarriers in Type B Niemann-Pick Disease Mice.

S. Muro, Melani A Solomon, E. Schuchman, 2017, Molecular therapy : the journal of the American Society of Gene Therapy.

ICAM‐1‐targeted nanocarriers attenuate endothelial release of soluble ICAM‐1, an inflammatory regulator

S. Muro, R. L. Manthe, 2017, Bioengineering & translational medicine.

Intra- and trans-cellular delivery of enzymes by direct conjugation with non-multivalent anti-ICAM molecules.

Abraham H. Abouzeid, S. Muro, W. Vreeland, 2016, Journal of controlled release : official journal of the Controlled Release Society.

A DNA Device that Mediates Selective Endosomal Escape and Intracellular Delivery of Drugs and Biologicals

S. Muro, 2014, Advanced functional materials.

Distinct Subcellular Trafficking Resulting from Monomeric vs Multimeric Targeting to Endothelial ICAM-1: Implications for Drug Delivery

S. Muro, Rasa Ghaffarian, 2014, Molecular pharmaceutics.

Intercellular Adhesion Molecule 1 Engagement Modulates Sphingomyelinase and Ceramide, Supporting Uptake of Drug Carriers by the Vascular Endothelium

T. Bhowmick, S. Muro, D. Serrano, 2012, Arteriosclerosis, thrombosis, and vascular biology.

Targeting delivery of drugs in the vascular system.

V. Muzykantov, S. Muro, 2011, International journal of transport phenomena.

Effect of Glycocalyx on Drug Delivery Carriers Targeted to Endothelial Cells.

V. Muzykantov, D. Eckmann, S. Muro, 2011, International journal of transport phenomena.

Size and targeting to PECAM vs ICAM control endothelial delivery, internalization and protective effect of multimolecular SOD conjugates.

V. Muzykantov, S. Muro, M. Khoshnejad, 2016, Journal of controlled release : official journal of the Controlled Release Society.

Oxygen microscopy by two-photon-excited phosphorescence.

Feng Gao, Silvia Muro, Sergei A Vinogradov, 2008, Chemphyschem : a European journal of chemical physics and physical chemistry.

Investigating polymer thiolation in gene delivery

W. Bentley, P. Kofinas, S. Muro, 2013, Journal of Biomaterials Science. Polymer Edition.

Efficient and Safe Intra-cellular Transport of Targeted Nanomedicines: are we there Yet?

S. Muro, 2011 .

Endothelial Biomedicine: Intercellular Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1

S. Muro, 2007 .

Nanoscale Antioxidant Therapeutics

V. Muzykantov, S. Muro, T. Dziubla, 2006 .

Targeting superoxide dismutase to endothelial caveolae profoundly alleviates inflammation caused by endotoxin

C. Villa, V. Muzykantov, R. Stan, 2018, Journal of controlled release : official journal of the Controlled Release Society.

Altered blood-brain barrier transport of nanotherapeutics in lysosomal storage diseases.

S. Muro, Melani A Solomon, Maximilian Loeck, 2022, Journal of controlled release : official journal of the Controlled Release Society.

Polymer-Based Drug Delivery Systems Under Investigation For Enzyme Replacement And Other Therapies Of Lysosomal Storage Disorders.

S. Muro, M. Giannotti, Marina Placci, 2023, Advanced drug delivery reviews.

Open challenges in magnetic drug targeting.

Benjamin Shapiro, Sandip Kulkarni, Aleksander Nacev, 2015, Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology.

Drug Delivery Across Physiological Barriers

S. Muro, 2016 .

Chitosan–Alginate Microcapsules Provide Gastric Protection and Intestinal Release of ICAM‐1‐Targeting Nanocarriers, Enabling GI Targeting In Vivo

S. Raghavan, S. Muro, Edgar Pérez-Herrero, 2016, Advanced functional materials.

Endocytosis and the Endolysosomal Route in Drug Delivery

S. Muro, I. Papademetriou, J. Rappaport, 2016 .

Targeting of antioxidant and anti-thrombotic drugs to endothelial cell adhesion molecules.

V. Muzykantov, S. Muro, 2005, Current pharmaceutical design.

Comparison between Nanoparticle Encapsulation and Surface Loading for Lysosomal Enzyme Replacement Therapy

S. Muro, Melani A Solomon, Eameema Muntimadugu, 2022, International journal of molecular sciences.

Specific Binding, Uptake, and Transport of ICAM-1-Targeted Nanocarriers Across Endothelial and Subendothelial Cell Components of the Blood–Brain Barrier

Silvia Muro, Janet Hsu, S. Muro, 2014, Pharmaceutical Research.

New biotechnological and nanomedicine strategies for treatment of lysosomal storage disorders.

S. Muro, 2010, Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology.

Engineering subtilisin proteases that specifically degrade active RAS

Eun Jung Choi, David J Weber, Yanan He, 2021, Communications Biology.

Engineering subtilisin proteases that specifically degrade active RAS

Eun Jung Choi, David J Weber, Yanan He, 2021, Communications biology.

Engineering protein-specific proteases: targeting active RAS

Eun Jung Choi, David J Weber, Yanan He, 2020, bioRxiv.

Nanomedicine and Drug Delivery Strategies for Treatment of Genetic Diseases

Silvia Muro, Janet Hsu, Janet Hsu, 2011 .

ICAM-1 recycling in endothelial cells: a novel pathway for sustained intracellular delivery and prolonged effects of drugs.

V. Muzykantov, S. Muro, Michael Koval, 2005, Blood.

Alterations in Cellular Processes Involving Vesicular Trafficking and Implications in Drug Delivery

S. Muro, 2018, Biomimetics.

Models and methods to evaluate transport of drug delivery systems across cellular barriers.

S. Muro, Rasa Ghaffarian, 2013, Journal of visualized experiments : JoVE.

Lysosomes and Nanotherapeutics: Diseases, Treatments, and Side Effects

S. Muro, R. L. Manthe, 2014 .

Control of endothelial targeting and intracellular delivery of therapeutic enzymes by modulating the size and shape of ICAM-1-targeted carriers.

Samir Mitragotri, Silvia Muro, Vladimir R Muzykantov, 2008, Molecular therapy : the journal of the American Society of Gene Therapy.

Flow dynamics, binding and detachment of spherical carriers targeted to ICAM-1 on endothelial cells.

Silvia Muro, Vladimir Muzykantov, V. Muzykantov, 2009, Biorheology.

Biological functionalization of drug delivery carriers to bypass size restrictions of receptor-mediated endocytosis independently from receptor targeting.

T. Bhowmick, S. Muro, I. Papademetriou, 2013, ACS nano.

Comparative binding, endocytosis, and biodistribution of antibodies and antibody-coated carriers for targeted delivery of lysosomal enzymes to ICAM-1 versus transferrin receptor

T. Bhowmick, S. Muro, E. Schuchman, 2013, Journal of Inherited Metabolic Disease.

Lysosomal enzyme delivery by ICAM-1-targeted nanocarriers bypassing glycosylation- and clathrin-dependent endocytosis.

V. Muzykantov, S. Muro, E. Schuchman, 2006, Molecular therapy : the journal of the American Society of Gene Therapy.

ICAM-directed vascular immunotargeting of antithrombotic agents to the endothelial luminal surface.

V. Muzykantov, D. Cines, S. Albelda, 2003, Blood.

Biodistribution and endocytosis of ICAM-1-targeting antibodies versus nanocarriers in the gastrointestinal tract in mice

S. Muro, V. Mane, 2012, International journal of nanomedicine.

Transport of nanocarriers across gastrointestinal epithelial cells by a new transcellular route induced by targeting ICAM-1.

T. Bhowmick, S. Muro, Rasa Ghaffarian, 2012, Journal of controlled release : official journal of the Controlled Release Society.

Advanced drug delivery systems that target the vascular endothelium.

Silvia Muro, Vladimir R Muzykantov, V. Muzykantov, 2006, Molecular interventions.

intracellular delivery and prolonged effects of drugs ICAM-1 recycling in endothelial cells: a novel pathway for sustained

V. Muzykantov, S. Muro, Michael Koval, 2013 .

A Fibrinogen-Derived Peptide Provides Intercellular Adhesion Molecule-1-Specific Targeting and Intraendothelial Transport of Polymer Nanocarriers in Human Cell Cultures and Mice

S. Muro, D. Serrano, C. Garnacho, 2012, Journal of Pharmacology and Experimental Therapeutics.

Immunotargeting of catalase to the pulmonary endothelium alleviates oxidative stress and reduces acute lung transplantation injury

D. Buerk, G. Patterson, V. Muzykantov, 2003, Nature Biotechnology.

Acute and chronic shear stress differently regulate endothelial internalization of nanocarriers targeted to platelet-endothelial cell adhesion molecule-1.

V. Muzykantov, Jingyan Han, P. Davies, 2012, ACS nano.

Endothelial targeting of antibody-decorated polymeric filomicelles.

Silvia Muro, Dennis E Discher, Eric Simone, 2011, ACS nano.

RhoA activation and actin reorganization involved in endothelial CAM-mediated endocytosis of anti-PECAM carriers: critical role for tyrosine 686 in the cytoplasmic tail of PECAM-1.

V. Muzykantov, S. Albelda, S. Muro, 2008, Blood.

The Development of Enzyme Replacement Therapy for Lysosomal Diseases: Gaucher Disease and Beyond

S. Muro, E. Schuchman, 2006 .

In Vivo Imaging of 64Cu-Labeled Polymer Nanoparticles Targeted to the Lung Endothelium

Silvia Muro, Michael J Welch, Raffaella Rossin, 2007, Journal of Nuclear Medicine.

Specific Binding, Uptake, and Transport of ICAM-1-Targeted Nanocarriers Across Endothelial and Subendothelial Cell Components of the Blood–Brain Barrier

Janet Hsu, S. Muro, J. Rappaport, 2014, Pharmaceutical Research.

Unprecedently high targeting specificity toward lung ICAM-1 using 3DNA nanocarriers.

Jessica Bowers, R. Getts, S. Muro, 2019, Journal of controlled release : official journal of the Controlled Release Society.

Targeted nanocarriers coopting pulmonary leukocytes for drug delivery to the injured brain

D. Weissman, S. Kasner, C. Villa, 2022, bioRxiv.

A method to improve quantitative radiotracing‐based analysis of the in vivo biodistribution of drug carriers

Jessica Bowers, R. Getts, S. Muro, 2020, Bioengineering & translational medicine.

Targeting, Endocytosis, and Lysosomal Delivery of Active Enzymes to Model Human Neurons by ICAM-1-Targeted Nanocarriers

J. Hoenicka, Janet Hsu, S. Muro, 2015, Pharmaceutical Research.

Effect of acid sphingomyelinase deficiency in type A Niemann-Pick disease on the transport of therapeutic nanocarriers across the blood–brain barrier

S. Muro, Maximilian Loeck, Marina Placci, 2023, Drug Delivery and Translational Research.

Strategies for delivery of therapeutics into the central nervous system for treatment of lysosomal storage disorders

S. Muro, 2012, Drug Delivery and Translational Research.

Targeted Nanocarriers Co-Opting Pulmonary Intravascular Leukocytes for Drug Delivery to the Injured Brain.

D. Weissman, S. Kasner, C. Villa, 2023, ACS nano.

Endothelial Biomedicine: Intercellular Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1

S. Muro, 2007 .

Role of the Lactide:Glycolide Ratio in PLGA Nanoparticle Stability and Release under Lysosomal Conditions for Enzyme Replacement Therapy of Lysosomal Storage Disorders

P. Pfeifer, S. Muro, Eameema Muntimadugu, 2023, Journal of functional biomaterials.

Open challenges in magnetic drug targeting.

B. Shapiro, I. Weinberg, P. Stepanov, 2015, Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology.

Co-coating of receptor-targeted drug nanocarriers with anti-phagocytic moieties enhances specific tissue uptake versus non-specific phagocytic clearance.

Janet Hsu, S. Muro, Edgar Pérez-Herrero, 2017, Biomaterials.

Biodegradable “Scaffold” Polyphosphazenes for Non-Covalent PEGylation of Proteins

T. Fuerst, S. Muro, A. Andrianov, 2018 .

Nanomedicine and Drug Delivery Strategies for Treatment of Genetic Diseases

Janet Hsu, S. Muro, 2011 .

Biological functionalization of drug delivery carriers to bypass size restrictions of receptor-mediated endocytosis independently from receptor targeting.

T. Bhowmick, S. Muro, I. Papademetriou, 2013, ACS Nano.

In vivo performance of polymer nanocarriers dually-targeted to epitopes of the same or different receptors.

S. Muro, E. Schuchman, I. Papademetriou, 2013, Biomaterials.

Endothelial targeting of antibody-decorated polymeric filomicelles.

D. Discher, V. Muzykantov, S. Muro, 2011, ACS nano.

Enhanced delivery of α-glucosidase for Pompe disease by ICAM-1-targeted nanocarriers: comparative performance of a strategy for three distinct lysosomal storage disorders.

T. Bhowmick, Janet Hsu, S. Muro, 2012, Nanomedicine : nanotechnology, biology, and medicine.