H. Arima

K. Motoyama, F. Hirayama, K. Uekama, 2009, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Lowering effect of dimethyl-α-cyclodextrin on GM1-ganglioside accumulation in GM1-gangliosidosis model cells and in brain of β-galactosidase-knockout mice

T. Era, T. Higashi, K. Motoyama, 2018, Journal of Inclusion Phenomena and Macrocyclic Chemistry.

Dual targeting system by supramolecular complex of folate-conjugated methyl-β-cyclodextrin with adamantane-grafted hyaluronic acid for the treatment of colorectal cancer.

T. Higashi, K. Motoyama, H. Arima, 2018, International journal of biological macromolecules.

Influence of Npc1 genotype on the toxicity of hydroxypropyl-β-cyclodextrin, a potentially therapeutic agent, in Niemann–Pick Type C disease models☆

K. Higaki, T. Higashi, K. Motoyama, 2014, Molecular genetics and metabolism reports.

Enhancement of curcumin wound healing ability by complexation with 2-hydroxypropyl-γ-cyclodextrin in sacran hydrogel film.

T. Higashi, K. Motoyama, H. Arima, 2017, International journal of biological macromolecules.

DAMP-Inducing Adjuvant and PAMP Adjuvants Parallelly Enhance Protective Type-2 and Type-1 Immune Responses to Influenza Split Vaccination

C. Coban, K. Ishii, T. Higashi, 2018, Front. Immunol..

Erratum: "Contribution of P-glycoprotein to the enhancing effects of dimethyl-β-cyclodextrin on oral bioavailability of tacrolimus" (The Journal of Pharmacology and Experimental Therapeutics (2001) 297 (547-555))

F. Hirayama, K. Uekama, H. Arima, 2001 .

In Vitro and In Vivo Tumor-Targeting siRNA Delivery Using Folate-PEG-appended Dendrimer (G4)/α-Cyclodextrin Conjugates.

T. Higashi, K. Motoyama, H. Arima, 2016, Bioconjugate chemistry.

Potential use of the complex of doxorubicin with folate-conjugated methyl-β-cyclodextrin for tumor-selective cancer chemotherapy

R. Kariya, S. Okada, T. Higashi, 2014, Journal of drug targeting.

Potential use of folate-appended methyl-^|^beta;-cyclodextrin as a novel antitumor agent

T. Higashi, K. Motoyama, H. Arima, 2013 .

Design and evaluation of folate-appended α-, β-, and γ-cyclodextrins having a caproic acid as a tumor selective antitumor drug carrier in vitro and in vivo.

T. Higashi, K. Motoyama, H. Arima, 2013, Biomacromolecules.

Design and evaluation of folate-appended methyl-β-cyclodextrin as a new antitumor agent

K. Motoyama, H. Arima, R. Onodera, 2011 .

Dendrimers as DNA carriers

H. Arima, 2005 .

Potential Use of Dendrimer/α-Cyclodextrin Conjugate as a Novel Carrier for Small Interfering RNA (siRNA)

F. Hirayama, K. Uekama, H. Arima, 2006 .

Scavenger receptors may regulate nitric oxide production from macrophages stimulated by LPS.

H. Arima, Y. Aramaki, S. Tsuchiya, 1997, Biochemical and biophysical research communications.

Evaluation of photodynamic activity of C60/2-hydroxypropyl-β-cyclodextrin nanoparticles.

K. Motoyama, F. Hirayama, K. Uekama, 2012, Journal of pharmaceutical sciences.

In vivo Efficacy and Safety Evaluation of Lactosyl-β-cyclodextrin as a Therapeutic Agent for Hepatomegaly in Niemann-Pick Type C Disease

T. Era, T. Higashi, K. Motoyama, 2019, Nanomaterials.

Inhibitory Effects of Novel Hydrophilic Cyclodextrin Derivatives on Nitric Oxide Production in Macrophages Stimulated with Lipopolysaccharide

K. Motoyama, F. Hirayama, K. Uekama, 2001, Pharmaceutical Research.

Enhanced secretion of hydrophobic peptide fused lysozyme by the introduction of N‐glycosylation signal and the disruption of calnexin gene in Saccharomyces cerevisiae

A. Kato, H. Arima, H. Azakami, 1998, FEBS letters.

Some pharmaceutical and inclusion properties of 2-hydroxybutyl-β-cyclodextrin derivative.

K. Motoyama, F. Hirayama, K. Uekama, 2011, International journal of pharmaceutics.

Involvement of lipid rafts of rabbit red blood cells in morphological changes induced by methylated beta-cyclodextrins.

K. Motoyama, F. Hirayama, K. Uekama, 2009, Biological & pharmaceutical bulletin.

Effect of 2,6-di-O-methyl-alpha-cyclodextrin on hemolysis and morphological change in rabbit's red blood cells.

K. Motoyama, F. Hirayama, K. Uekama, 2006, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Protective effect of sulfobutyl ether beta-cyclodextrin on DY-9760e-induced hemolysis in vitro.

S. Tajiri, F. Hirayama, K. Uekama, 2002, Journal of pharmaceutical sciences.

In vitro and in vivo gene transfer by an optimized alpha-cyclodextrin conjugate with polyamidoamine dendrimer.

F. Hirayama, K. Uekama, H. Arima, 2003, Bioconjugate chemistry.

Identification of candidate molecular targets of the novel antineoplastic antimitotic NP-10

M. Fujita, H. Kosako, T. Higashi, 2019, Scientific Reports.

In vitro gene delivery mediated by lactosylated dendrimer (generation 3, G3)/α-cyclodextrin conjugates into hepatocytes

H. Jono, K. Motoyama, F. Hirayama, 2011 .

Preparation and evaluation of polyamidoamine dendrimer (G2)/branched-β-cyclodextrin conjugate as a novel gene transfer carrier

T. Anno, T. Higashi, K. Motoyama, 2011 .

Serum-resistant Gene Transfer Activity of Mannosylated Dendrimer/α-Cyclodextrin Conjugate (G3)

F. Hirayama, K. Uekama, H. Arima, 2006 .

Enhancement of gene transfer activity mediated by mannosylated dendrimer/alpha-cyclodextrin conjugate (generation 3, G3).

F. Hirayama, K. Uekama, H. Arima, 2006, Journal of controlled release : official journal of the Controlled Release Society.

Evaluation of polyamidoamine dendrimer/alpha-cyclodextrin conjugate (generation 3, G3) as a novel carrier for small interfering RNA (siRNA).

Hidetoshi Arima, F. Hirayama, K. Uekama, 2007, Journal of controlled release : official journal of the Controlled Release Society.

Potential use of fucose-appended dendrimer/α-cyclodextrin conjugates as NF-κB decoy carriers for the treatment of lipopolysaccharide-induced fulminant hepatitis in mice.

T. Higashi, K. Motoyama, H. Arima, 2014, Journal of controlled release : official journal of the Controlled Release Society.

Design and evaluation of polyamidoamine dendrimer conjugate with PEG, α-cyclodextrin and lactose as a novel hepatocyte-selective gene carrier in vitro and in vivo

H. Jono, T. Higashi, K. Motoyama, 2013, Journal of drug targeting.

Involvement of CD14 in the inhibitory effects of dimethyl‐α‐cyclodextrin on lipopolysaccharide signaling in macrophages

K. Miyake, K. Motoyama, F. Hirayama, 2005, FEBS letters.

Recent Aspect of Cyclodextrin-Based Drug Delivery System

F. Hirayama, K. Uekama, H. Arima, 2006 .

Differential Effects of 2-Hydroxypropyl-Cyclodextrins on Lipid Accumulation in Npc1-Null Cells

K. Higaki, T. Higashi, K. Motoyama, 2020, International journal of molecular sciences.

In vitro evaluation of 2-hydroxyalkylated β-cyclodextrins as potential therapeutic agents for Niemann-Pick Type C disease.

K. Higaki, T. Higashi, K. Motoyama, 2016, Molecular genetics and metabolism.

Effects of cyclodextrins on GM1‐gangliosides in fibroblasts from GM1‐gangliosidosis patients

T. Era, T. Higashi, K. Motoyama, 2015, The Journal of pharmacy and pharmacology.

Differential mode of cholesterol inclusion with 2‐hydroxypropyl‐cyclodextrins increases safety margin in treatment of Niemann‐Pick disease type C

F. Hirata, T. Kikuchi, K. Higaki, 2021, British journal of pharmacology.

Effects of oligodeoxynucleotides on the physicochemical characteristics and cellular uptake of liposomes.

H. Arima, Y. Aramaki, S. Tsuchiya, 1997, Journal of pharmaceutical sciences.

Potential use of glucuronylglucosyl-β-cyclodextrin/dendrimer conjugate (G2) as a DNA carrier in vitro and in vivo

T. Anno, T. Higashi, K. Motoyama, 2012, Journal of drug targeting.

Efficient Anticancer Drug Delivery for Pancreatic Cancer Treatment Utilizing Supramolecular Polyethylene-Glycosylated Bromelain.

T. Higashi, K. Motoyama, H. Arima, 2020, ACS applied bio materials.

Potential use of folate-polyethylene glycol (PEG)-appended dendrimer (G3) conjugate with α-cyclodextrin as DNA carriers to tumor cells

T. Higashi, K. Motoyama, F. Hirayama, 2012, Cancer Gene Therapy.

Effects of structure of polyamidoamine dendrimer on gene transfer efficiency of the dendrimer conjugate with alpha-cyclodextrin.

F. Hirayama, K. Uekama, H. Arima, 2002, Bioconjugate chemistry.

Multifunctional Therapeutic Cyclodextrin-Appended Dendrimer Complex for Treatment of Systemic and Localized Amyloidosis.

H. Jono, M. Mizuguchi, T. Higashi, 2022, ACS applied materials & interfaces.

Improvement of dermatitis by iontophoretically delivered antisense oligonucleotides for interleukin-10 in NC/Nga mice

H. Arima, Y. Aramaki, T. Sakamoto, 2004, Gene Therapy.

Systemic delivery of transthyretin siRNA mediated by lactosylated dendrimer/α-cyclodextrin conjugates into hepatocyte for familial amyloidotic polyneuropathy therapy

H. Jono, T. Higashi, K. Motoyama, 2012, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.

Anti-allergic effects of novel sulfated polysaccharide sacran on mouse model of 2,4-Dinitro-1-fluorobenzene-induced atopic dermatitis.

T. Higashi, K. Motoyama, H. Arima, 2018, International journal of biological macromolecules.

Involvement of lipid rafts in macrophage apoptosis induced by cationic liposomes.

Y. Negishi, H. Arima, Y. Aramaki, 2011, Archives of biochemistry and biophysics.

The antitumor effects of methyl-β-cyclodextrin against primary effusion lymphoma via the depletion of cholesterol from lipid rafts.

R. Kariya, S. Okada, K. Motoyama, 2014, Biochemical and biophysical research communications.

Methyl-Beta-Cyclodextrin Improves Fertilizing Ability of C57BL/6 Mouse Sperm after Freezing and Thawing by Facilitating Cholesterol Efflux from the Cells1

K. Yamamura, H. Arima, T. Irie, 2008, Biology of reproduction.

freezing and thawing by facilitating cholesterol efflux from the cells 1

K. Yamamura, H. Arima, T. Irie, 2007 .

Intradermal delivery of antisense oligonucleotides by the pulse depolarization iontophoretic system.

H. Arima, Y. Aramaki, T. Sakamoto, 2003, Biological & pharmaceutical bulletin.

Fine-tuned cholesterol solubilizer, mono-6-O-α-D-maltosyl-γ-cyclodextrin, ameliorates experimental Niemann-Pick disease type C without hearing loss.

K. Higaki, T. Higashi, K. Motoyama, 2022, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Release characteristics of a short-chain fatty acid, n-butyric acid, from its beta-cyclodextrin ester conjugate in rat biological media.

F. Hirayama, K. Uekama, H. Arima, 2000, Journal of pharmaceutical sciences.

Inhibitory Effects of 2,6-Di-O-methyl-3-O-acetyl-β-cyclodextrins with Various Degrees of Substitution of Acetyl Group on Macrophage Activation and Endotoxin Shock Induced by Lipopolysaccharide

K. Motoyama, F. Hirayama, K. Uekama, 2006 .

Enhancement of transdermal protein delivery by photothermal effect of gold nanorods coated on polysaccharide‐based hydrogel

T. Niidome, T. Higashi, K. Motoyama, 2017, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Comparison of ovalbumin and ovalbumin epitope peptide for transdermal delivery and vaccination mediated by the photothermal effect of gold nanorods

T. Niidome, T. Higashi, K. Motoyama, 2017, Journal of biomaterials science. Polymer edition.

Cyclodextrin-based sustained and controllable release system of insulin utilizing the combination system of self-assembly PEGylation and polypseudorotaxane formation.

T. Higashi, K. Motoyama, H. Arima, 2017, Carbohydrate polymers.

Peak-less hypoglycemic effect of insulin glargine by complexation with maltosyl-β-cyclodextrin.

T. Anno, T. Higashi, K. Motoyama, 2012, International journal of pharmaceutics.

Determination of stability constant of beta-cyclodextrin complexes using the membrane permeation technique and the permeation behavior of drug-competing agent-beta-cyclodextrin ternary systems.

F. Hirayama, K. Uekama, H. Arima, 1999, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Involvement of mitophagy-mediated cell death in colon cancer cells by folate-appended methyl-β-cyclodextrin

T. Higashi, K. Motoyama, H. Arima, 2017, Journal of Inclusion Phenomena and Macrocyclic Chemistry.

Involvement of cholesterol depletion from lipid rafts in apoptosis induced by methyl-β-cyclodextrin.

R. Kariya, S. Okada, T. Higashi, 2013, International journal of pharmaceutics.

Inhibitory effects of dimethylacetyl-beta-cyclodextrin on lipopolysaccharide-induced macrophage activation and endotoxin shock in mice.

A. Matsukawa, K. Motoyama, F. Hirayama, 2005, Biochemical pharmacology.

A moderate interaction of maltosyl-alpha-cyclodextrin with Caco-2 cells in comparison with the parent cyclodextrin.

F. Hirayama, K. Uekama, H. Arima, 2001, Biological & pharmaceutical bulletin.

Improvement of gene delivery mediated by mannosylated dendrimer/alpha-cyclodextrin conjugates.

F. Hirayama, K. Uekama, H. Arima, 2005, Journal of controlled release : official journal of the Controlled Release Society.

Hepatocyte-Targeted Delivery of siRNA Polyplex with PEG-Modified Lactosylated Dendrimer/Cyclodextrin Conjugates for Transthyretin-Related Amyloidosis Therapy.

H. Jono, T. Higashi, K. Motoyama, 2019, Biological & pharmaceutical bulletin.

Potential use of a megamolecular polysaccharide sacran as a hydrogel-based sustained release system.

T. Higashi, K. Motoyama, H. Arima, 2014, Chemical & pharmaceutical bulletin.

Intracerebroventricular Treatment with 2-Hydroxypropyl-β-Cyclodextrin Decreased Cerebellar and Hepatic Glycoprotein Nonmetastatic Melanoma Protein B (GPNMB) Expression in Niemann–Pick Disease Type C Model Mice

K. Higaki, T. Higashi, K. Motoyama, 2021, International journal of molecular sciences.

Prolonged Retention of Doxorubicin in Tumor Cells by Encapsulation of γ-Cyclodextrin Complex in Pegylated Liposomes

F. Hirayama, K. Uekama, H. Arima, 2006 .

Enhancement of antitumor effect of doxorubicin by its complexation with γ-cyclodextrin in pegylated liposomes

F. Hirayama, K. Uekama, H. Arima, 2006, Journal of drug targeting.

Negatively charged liposomes inhibit tyrosine phosphorylation of 41-kDa protein in murine macrophages stimulated with LPS.

H. Arima, Y. Aramaki, S. Tsuchiya, 1997, Biochemical and biophysical research communications.

Liposomal Induction of a Heat-stable Macrophage Priming Factor to Induce Nitric Oxide in Response to LPS

H. Arima, Y. Aramaki, S. Tsuchiya, 1996, Pharmaceutical Research.

Isolation of Antimicrobial Compounds from Guava (Psidium guajava L.) and their Structural Elucidation

H. Arima, G. Danno, 2002, Bioscience, biotechnology, and biochemistry.

FRET‐Based In‐Cell Detection of Highly Selective Supramolecular Complexes of meso‐Tetraarylporphyrin with Peptide/BODIPY‐Modified Per‐O‐Methyl‐β‐Cyclodextrins

H. Arima, H. Kitagishi, G. Gouhier, 2021, Chembiochem : a European journal of chemical biology.

Improvement of some physicochemical properties of arundic acid, (R)-(-)-2-propyloctanonic acid, by complexation with hydrophilic cyclodextrins.

K. Motoyama, F. Hirayama, K. Uekama, 2011, International journal of pharmaceutics.

Cholesterol-Lowering Effect of Octaarginine-Appended β-Cyclodextrin in Npc1-Trap-CHO Cells.

S. Futaki, T. Era, Yoshimasa Kawaguchi, 2016, Biological & pharmaceutical bulletin.

Preparation and pharmaceutical evaluation of liposomes entrapping salicylic acid/gamma-cyclodextrin conjugate.

F. Hirayama, K. Uekama, H. Arima, 2006, Chemical & pharmaceutical bulletin.

Crystal structure of heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin complexes with m-iodophenol and 4-biphenylacetic acid. Guest-induced conformational change of a pyranose ring

K. Harata, F. Hirayama, K. Uekama, 1992 .

Role of 6-O-α-maltosyl-β-cyclodextrin in lysosomal cholesterol deprivation in Npc1-deficient Chinese hamster ovary cells.

K. Higaki, T. Higashi, K. Motoyama, 2018, Carbohydrate research.

Sacran: Novel Sulfated Polysaccharide as Anti-Allergic Skincare Biomaterial for Atopic Dermatitis

N. R. Ngatu, T. Higashi, K. Motoyama, 2018 .

Anti-inflammatory Effects of Novel Polysaccharide Sacran Extracted from Cyanobacterium Aphanothece sacrum in Various Inflammatory Animal Models.

T. Higashi, K. Motoyama, H. Arima, 2016, Biological & pharmaceutical bulletin.

Clinical Evaluation of Novel Natural Polysaccharides Sacran as a Skincare Material for Atopic Dermatitis Patients

S. Fukushima, H. Ihn, T. Higashi, 2016 .

Colon-specific delivery of prednisolone-appended alpha-cyclodextrin conjugate: alleviation of systemic side effect after oral administration.

F. Hirayama, K. Uekama, H. Arima, 2002, Journal of controlled release : official journal of the Controlled Release Society.

Preparation of prednisolone‐appended α‐, β‐ and γ‐cyclodextrins: Substitution at secondary hydroxyl groups and in vitro hydrolysis behavior

F. Hirayama, K. Uekama, H. Arima, 2001 .

Design and Evaluation of the Highly Concentrated Human IgG Formulation Using Cyclodextrin Polypseudorotaxane Hydrogels

T. Higashi, K. Motoyama, H. Arima, 2015, AAPS PharmSciTech.

Rutin-enhanced Antibacterial Activities of BaeiUus cereus and SalmoneUa enteritidisFlavonoids against JSmu

H. Ashida, H. Arima, 2018 .

Rutin-enhanced Antibacterial Activities of Flavonoids against Bacillus cereus and Salmonella enteritidis

H. Ashida, H. Arima, G. Danno, 2002, Bioscience, biotechnology, and biochemistry.

A clue to unprecedented strategy to HIV eradication: “Lock-in and apoptosis”

T. Higashi, K. Motoyama, H. Arima, 2017, Scientific Reports.

One-pot synthesis of cyclodextrin-based radial poly[n]catenanes

Jun Li, N. Yui, Xia Song, 2019, Communications Chemistry.

Supramolecular Pharmaceutical Sciences: A Novel Concept Combining Pharmaceutical Sciences and Supramolecular Chemistry with a Focus on Cyclodextrin-Based Supermolecules.

T. Higashi, K. Motoyama, H. Arima, 2018, Chemical & pharmaceutical bulletin.

Pharmaceutical evaluation of hydroxyalkyl ethers of β-cyclodextrins

K. Uekama, H. Arima, J. Pitha, 1988 .

Cyclodextrin-Induced Change in Crystal Habit of Acetylsalicylic Acid in Aqueous Solution

K. Motoyama, F. Hirayama, K. Uekama, 2012 .

Twenty Years of Research on Cyclodextrin Conjugates with PAMAM Dendrimers

H. Arima, 2021, Pharmaceutics.

In Vitro and In Vivo Co-delivery of siRNA and Doxorubicin by Folate-PEG-Appended Dendrimer/Glucuronylglucosyl-β-Cyclodextrin Conjugate

T. Higashi, K. Motoyama, H. Arima, 2019, The AAPS Journal.

Recent advances in cyclodextrin delivery techniques

T. Higashi, K. Motoyama, H. Arima, 2015, Expert opinion on drug delivery.

Preparation and evaluation of cyclodextrin polypseudorotaxane with PEGylated liposome as a sustained release drug carrier

T. Higashi, K. Motoyama, H. Arima, 2014, Beilstein journal of organic chemistry.

Antigen stabilizing hydrogels based on cyclodextrins and polyethylene glycol act as type-2 adjuvants with suppressed local irritation.

T. Higashi, K. Motoyama, H. Arima, 2022, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

5-Fluorouracil acetic acid/beta-cyclodextrin conjugates: drug release behavior in enzymatic and rat cecal media.

K. Motoyama, F. Hirayama, K. Uekama, 2010, International journal of pharmaceutics.

Cyclodextrin conjugate-based controlled release system: repeated- and prolonged-releases of ketoprofen after oral administration in rats.

F. Hirayama, K. Uekama, H. Arima, 2002, Journal of controlled release : official journal of the Controlled Release Society.

Model Analysis for Oral Absorption of a Drug/Cyclodextrin Complex Involving Competitive Inclusion Complexes

F. Hirayama, K. Uekama, H. Arima, 2002 .

Recent Findings on Safety Profiles of Cyclodextrins, Cyclodextrin Conjugates, and Polypseudorotaxanes

K. Motoyama, H. Arima, T. Irie, 2011 .

Inclusion Complexation of a Seleno-Organic Antioxidant, Ebselen, with Cyclodextrins in Aqueous Solution

Sunyong Kim, F. Hirayama, K. Uekama, 2002 .

Predicting the Binding Mode of 2-Hydroxypropyl-β-cyclodextrin to Cholesterol by Means of the MD Simulation and the 3D-RISM-KH Theory.

F. Hirata, T. Kikuchi, H. Arima, 2018, The journal of physical chemistry. B.

Selective Crystallization of the Metastable Form IV Polymorph of Tolbutamide in the Presence of 2,6-Di-O-methyl-β-cyclodextrin in Aqueous Solution

W. Saenger, Y. Yamaguchi, F. Hirayama, 2006 .

Sustained release of buserelin acetate, a luteinizing hormone‐releasing hormone agonist, from an injectable oily preparation utilizing ethylated β‐cyclodextrin

K. Uekama, H. Arima, T. Irie, 1989, The Journal of pharmacy and pharmacology.

Enhancement of the Antiinflammatory Effect of Ethyl 4-Biphenylyl Acetate in Ointment by β-Cyclodextrin Derivatives: Increased Absorption and Localized Activation of the Prodrug in Rats

K. Uekama, H. Arima, J. Pitha, 1990, Pharmaceutical Research.

Improvement of Solubility and Oral Bioavailability of Rutin by Complexation with 2-Hydroxypropyl-β-cyclodextrin

F. Hirayama, K. Uekama, H. Arima, 2000, Pharmaceutical development and technology.

Enhancing effect of hydroxypropyl-beta-cyclodextrin on cutaneous penetration and activation of ethyl 4-biphenylyl acetate in hairless mouse skin.

F. Hirayama, K. Uekama, H. Arima, 1998, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Effect of 2-Hydroxypropyl-Cyclodextrins on Percutaneous Absorption of p-Hydroxybenzoic Acid

K. Uekama, H. Arima, H. Matsuda, 1996 .

Improved Drug Delivery Through the Skin by Hydrophilic β-Cyclodextrins

Hidetoshi Arima, K. Uekama, H. Arima, 1990 .

Differences in the enhancing effects of water soluble β-cyclodextrins on the release of ethyl 4-biphenylyl acetate, an anti-inflammatory agent from an oleaginous suppository base

K. Uekama, H. Arima, T. Irie, 1989 .

Design and evaluation of polypseudorotaxanes of pegylated insulin with cyclodextrins as sustained release system.

T. Higashi, F. Hirayama, K. Uekama, 2008, Biomaterials.

Stabilizing and Solubilizing Effects of Sulfobutyl Ether β-Cyclodextrin on Prostaglandin E1 Analogue

M. Sudoh, F. Hirayama, K. Uekama, 2001, Pharmaceutical Research.

NMR spectroscopic characterization of metoprolol/cyclodextrin complexes in aqueous solution: cavity size dependency.

F. Hirayama, K. Uekama, H. Arima, 2004, Journal of pharmaceutical sciences.

Crystallization and polymorphic transitions of chlorpropamide in aqueous 2-hydroxybutyl-beta-cyclodextrin solution.

F. Hirayama, K. Uekama, H. Arima, 2010, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Preparation of amorphous indomethacin from aqueous 2,6-di-O-methyl-beta-cyclodextrin solution.

F. Hirayama, K. Uekama, H. Arima, 2008, International journal of pharmaceutics.

Heptakis(2,6-di-O-methyl-3-O-acetyl)-beta-cyclodextrin: A water-soluble cyclodextrin derivative with low hemolytic activity.

F. Hirayama, K. Uekama, H. Arima, 1999, Journal of pharmaceutical sciences.

Thermoresponsive Formation of Dimethyl Cyclodextrin Polypseudorotaxanes and Subsequent One-Pot Synthesis of Polyrotaxanes

Jun Li, Xia Song, Jingling Zhu, 2016 .

Enhanced bioavailability of a new thiazolidine derivative FPFS-410, an antidiabetic and lipid-lowering drug, after oral administration of its hydroxypropyl-beta-cyclodextrin complex to bile duct-cannulated rats.

F. Hirayama, K. Uekama, H. Arima, 2006, Journal of pharmaceutical sciences.

Release control of fragrances by complexation with β-cyclodextrin and its derivatives

F. Hirayama, K. Uekama, H. Arima, 2018, Journal of Inclusion Phenomena and Macrocyclic Chemistry.

Characterization of itraconazole/2-hydroxypropyl-beta-cyclodextrin inclusion complex in aqueous propylene glycol solution.

F. Hirayama, K. Uekama, H. Arima, 1999, International journal of pharmaceutics.

Involvement of PI3K-Akt-Bad pathway in apoptosis induced by 2,6-di-O-methyl-beta-cyclodextrin, not 2,6-di-O-methyl-alpha-cyclodextrin, through cholesterol depletion from lipid rafts on plasma membranes in cells.

K. Motoyama, F. Hirayama, K. Uekama, 2009, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Slow-release system of pegylated lysozyme utilizing formation of polypseudorotaxanes with cyclodextrins.

T. Higashi, F. Hirayama, K. Uekama, 2009, International journal of pharmaceutics.

Polypseudorotaxane formation of randomly-pegylated insulin with cyclodextrins: slow release and resistance to enzymatic degradation.

T. Higashi, K. Motoyama, F. Hirayama, 2009, Chemical & pharmaceutical bulletin.

[Supramolecular Pharmaceutical Sciences: A Novel Concept for Future Pharmaceutical Sciences].

T. Higashi, K. Motoyama, H. Arima, 2019, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Targeted siRNA delivery to tumor cells by folate-PEG-appended dendrimer/glucuronylglucosyl-β-cyclodextrin conjugate

T. Higashi, K. Motoyama, H. Arima, 2018, Journal of Inclusion Phenomena and Macrocyclic Chemistry.

Preparation and evaluation of polyamidoamine dendrimer conjugate with glucuronylglucosyl-β-cyclodextrin (G3) as a novel carrier for siRNA

T. Higashi, K. Motoyama, H. Arima, 2014, Journal of drug targeting.

Potential use of glucuronylglucosyl-β-cyclodextrin/dendrimer conjugate (G2) as a siRNA carrier for the treatment of familial amyloidotic polyneuropathy

H. Jono, T. Anno, T. Higashi, 2014, Journal of drug targeting.

Self-Assembly PEGylation Retaining Activity (SPRA) Technology via a Host-Guest Interaction Surpassing Conventional PEGylation Methods of Proteins.

T. Higashi, K. Motoyama, H. Arima, 2017, Molecular pharmaceutics.

Improvement of some pharmaceutical properties of DY-9760e by sulfobutyl ether beta-cyclodextrin.

F. Hirayama, K. Uekama, H. Arima, 2001, International journal of pharmaceutics.

Stabilizing Effects for Antibody Formulations and Safety Profiles of Cyclodextrin Polypseudorotaxane Hydrogels.

T. Higashi, K. Motoyama, H. Arima, 2017, Journal of pharmaceutical sciences.

Cyclodextrin/poly(ethylene glycol) polypseudorotaxane hydrogels as a promising sustained-release system for lysozyme.

T. Higashi, K. Motoyama, H. Arima, 2012, Journal of pharmaceutical sciences.

Potential use of gamma-cyclodextrin polypseudorotaxane hydrogels as an injectable sustained release system for insulin.

Keiichi Motoyama, Hidetoshi Arima, Taishi Higashi, 2010, International journal of pharmaceutics.

Improvement of pharmaceutical properties of insulin through conjugation with glucuronylglucosyl-β-cyclodextrin

T. Higashi, K. Motoyama, F. Hirayama, 2014, Journal of Inclusion Phenomena and Macrocyclic Chemistry.

Prednisolone‐appended α‐cyclodextrin: Alleviation of systemic adverse effect of prednisolone after intracolonic administration in 2,4,6‐trinitrobenzenesulfonic acid‐induced colitis rats

F. Hirayama, K. Uekama, H. Arima, 2001 .

Preparation of prednisolone-appended alpha-, beta- and gamma-cyclodextrins: substitution at secondary hydroxyl groups and in vitro hydrolysis behavior.

F. Hirayama, K. Uekama, H. Arima, 2001, Journal of pharmaceutical sciences.

Controlled release of a water-soluble drug, captopril, by a combination of hydrophilic and hydrophobic cyclodextrin derivatives.

F. Hirayama, K. Uekama, H. Arima, 2000, Journal of controlled release : official journal of the Controlled Release Society.

Analysis of the phase solubility diagram of a phenacetin/competitor/beta-cyclodextrin ternary system, involving competitive inclusion complexation.

F. Hirayama, K. Uekama, H. Arima, 2001, Chemical & pharmaceutical bulletin.

Solid-State 13C Nuclear Magnetic Resonance Spectroscopic Study on Amorphous Solid Complexes of Tolbutamide with 2-Hydroxypropyl-α-and -β-Cyclodextrins

Hidetoshi Arima, F. Hirayama, K. Uekama, 1999, Pharmaceutical Research.

Effects of Hydrophilic Cyclodextrins on Aggregation of Recombinant Human Growth Hormone

S. Tajiri, F. Hirayama, K. Uekama, 2004, Pharmaceutical Research.

Polypseudorotaxanes of pegylated α-cyclodextrin/polyamidoamine dendrimer conjugate with cyclodextrins as a sustained release system for DNA.

T. Higashi, K. Motoyama, H. Arima, 2012, Bioorganic & medicinal chemistry.

6-O-α-(4-O-α-D-glucuronyl)-D-glucosyl-β-cyclodextrin: solubilizing ability and some cellular effects

F. Hirayama, K. Uekama, H. Arima, 2002 .

Improved stability of Opalmon tablets under humid conditions IV: effect of polysaccharides and disintegrants on the stability and dissolution property of Opalmon tablets.

F. Hirayama, K. Uekama, H. Arima, 2008, Chemical & pharmaceutical bulletin.

Contribution of Cholesterol and Phospholipids to Inhibitory Effect of Dimethyl-β-Cyclodextrin on Efflux Function of P-Glycoprotein and Multidrug Resistance-Associated Protein 2 in Vinblastine-Resistant Caco-2 Cell Monolayers

Hidetoshi Arima, F. Hirayama, K. Uekama, 2004, Pharmaceutical Research.

Potential Use of 2-Hydroxypropyl-β-cyclodextrin for Preparation of Orally Disintegrating Tablets Containing dl -α-Tocopheryl Acetate, an Oily Drug

K. Motoyama, F. Hirayama, K. Uekama, 2009 .

Potential use of 2-hydroxypropyl-beta-cyclodextrin for preparation of orally disintegrating tablets containing dl-alpha-tocopheryl acetate, an oily drug.

K. Motoyama, F. Hirayama, K. Uekama, 2009, Chemical & pharmaceutical bulletin.

Inclusion Complex Formation of Captopril with α‐ and β‐Cyclodextrins in Aqueous Solution: NMR Spectroscopic and Molecular Dynamic Studies

F. Hirayama, K. Uekama, H. Arima, 2002 .

Potential Use of Cyclodextrins as Drug Carriers and Active Pharmaceutical Ingredients.

Keiichi Motoyama, Hidetoshi Arima, Taishi Higashi, 2017, Chemical & pharmaceutical bulletin.

Improvement of the bitter taste of drugs by complexation with cyclodextrins: applications, evaluations and mechanisms.

T. Higashi, K. Motoyama, H. Arima, 2012, Therapeutic delivery.

Involvement of cholesterol in the inhibitory effect of dimethyl‐β‐cyclodextrin on P‐glycoprotein and MRP2 function in Caco‐2 cells

Hidetoshi Arima, F. Hirayama, K. Uekama, 2003, FEBS letters.

Comparative studies of the enhancing effects of cyclodextrins on the solubility and oral bioavailability of tacrolimus in rats.

F. Hirayama, K. Uekama, H. Arima, 2001, Journal of pharmaceutical sciences.

Cyclodextrin, a novel therapeutic tool for suppressing amyloidogenic transthyretin misfolding in transthyretin-related amyloidosis.

H. Jono, M. Mizuguchi, T. Anno, 2011, The Biochemical journal.

Potential use of niosomal hydrogel as an ocular delivery system for atenolol.

H. Arima, I. I. Abu Hashim, A. H. Abd-Elgawad, 2014, Biological & pharmaceutical bulletin.

A comprehensive understanding of lowly-hydrolyzed polyvinyl alcohol-based ternary solid dispersions with the use of a combined mixture-process design

T. Higashi, K. Motoyama, H. Arima, 2019, Drug development and industrial pharmacy.

2-Hydroxypropyl-β-Cyclodextrin Acts as a Novel Anticancer Agent

S. Kimura, Y. Tabe, T. Higashi, 2015, PloS one.

Contribution of P-glycoprotein to the enhancing effects of dimethyl-beta-cyclodextrin on oral bioavailability of tacrolimus.

F. Hirayama, K. Uekama, H. Arima, 2001, The Journal of pharmacology and experimental therapeutics.

The Use of Megamolecular Polysaccharide Sacran in Food and Biomedical Applications

H. Arima, I. Joni, A. F. Mohammed, 2021, Molecules.

Folate-appended cyclodextrin improves the intratumoral accumulation of existing boron compounds.

H. Ishikawa, H. Sakurai, Y. Matsumoto, 2020, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

Sugar-appended polyamidoamine dendrimer conjugates with cyclodextrins as cell-specific non-viral vectors.

Keiichi Motoyama, Hidetoshi Arima, Taishi Higashi, 2013, Advanced drug delivery reviews.

Efficacy of 2-Hydroxypropyl-β-cyclodextrin in Niemann-Pick Disease Type C Model Mice and Its Pharmacokinetic Analysis in a Patient with the Disease.

K. Higaki, T. Higashi, K. Motoyama, 2015, Biological & pharmaceutical bulletin.

Reduction of bitterness of antihistaminic drugs by complexation with β-cyclodextrins.

Keiichi Motoyama, Hidetoshi Arima, Satoshi Tsuruta, 2011, Journal of pharmaceutical sciences.

Design and Evaluation of Thioalkylated Mannose-Modified Dendrimer (G3)/α-Cyclodextrin Conjugates as Antigen-Presenting Cell-Selective siRNA Carriers

T. Higashi, K. Motoyama, H. Arima, 2014, The AAPS Journal.

Enhanced absorption of cyclosporin A by complexation with dimethyl-beta-cyclodextrin in bile duct-cannulated and -noncannulated rats.

F. Hirayama, K. Uekama, H. Arima, 1999, Biological & pharmaceutical bulletin.

A Mannosylated, PEGylated Albumin as a Drug Delivery System for the Treatment of Cancer Stroma Cells

Teruya Nakamura, H. Arima, M. Otagiri, 2021, Advanced Functional Materials.

Induction of mitophagy-mediated antitumor activity with folate-appended methyl-β-cyclodextrin

T. Higashi, K. Motoyama, H. Arima, 2017, International journal of nanomedicine.

Theoretical and practical evaluation of lowly hydrolyzed polyvinyl alcohol as a potential carrier for hot‐melt extrusion

T. Higashi, K. Motoyama, H. Arima, 2019, International journal of pharmaceutics.

Improvement of dissolution properties of a new Helicobacter pylori eradicating agent (TG44) by inclusion complexation with beta-cyclodextrin.

F. Hirayama, K. Uekama, H. Arima, 2007, Chemical & pharmaceutical bulletin.

A clue to unprecedented strategy to HIV eradication: “Lock-in and apoptosis”

T. Higashi, K. Motoyama, H. Arima, 2017, Scientific Reports.

Identification of molecular‐interaction sites between lowly hydrolyzed polyvinyl alcohols and indomethacin by NMR spectroscopy

T. Higashi, K. Motoyama, H. Arima, 2018, International journal of pharmaceutics.

Effects of dendrimer/cyclodextrin conjugates as gene transfer carriers on nitric oxide production from macrophages

T. Higashi, K. Motoyama, H. Arima, 2016, The Journal of pharmacy and pharmacology.

WITHDRAWN: Supplemental therapy of tumor suppressor microRNA using folate-PEG-appended dendrimer (G4) conjugate with α-cyclodextrin

T. Higashi, K. Motoyama, H. Arima, 2015 .

Folate-PEG-appended dendrimer conjugate with α-cyclodextrin as a novel cancer cell-selective siRNA delivery carrier.

T. Niidome, Y. Katayama, A. Tsuchiya, 2012, Molecular pharmaceutics.

Physically crosslinked-sacran hydrogel films for wound dressing application.

T. Higashi, K. Motoyama, H. Arima, 2016, International journal of biological macromolecules.

Effect of sulfobutyl ether-β-cyclodextrin on bioavailability of insulin glargine and blood glucose level after subcutaneous injection to rats.

T. Anno, K. Motoyama, F. Hirayama, 2011, International journal of pharmaceutics.

Sacran, a sulfated polysaccharide, suppresses the absorption of lipids and modulates the intestinal flora in non-alcoholic steatohepatitis model rats.

K. Azuma, T. Higashi, K. Motoyama, 2021, Life sciences.

In vitro and in vivo gene delivery mediated by Lactosylated dendrimer/alpha-cyclodextrin conjugates (G2) into hepatocytes.

Keiichi Motoyama, Yukio Ando, Hidetoshi Arima, 2010, Journal of controlled release : official journal of the Controlled Release Society.

Therapeutic Potential of Polyamidoamine Dendrimer for Amyloidogenic Transthyretin Amyloidosis.

H. Jono, M. Mizuguchi, T. Anno, 2019, ACS chemical neuroscience.

Effects of intracerebroventricular administration of 2-hydroxypropyl-β-cyclodextrin in a patient with Niemann–Pick Type C disease

H. Arima, T. Irie, M. Matsuo, 2014, Molecular genetics and metabolism reports.

Specific inhibition of nitric oxide production in macrophages by phosphorothioate antisense oligonucleotides.

H. Arima, Y. Aramaki, T. Sakamoto, 1997, Journal of pharmaceutical sciences.

Enhancing effect of γ-cyclodextrin on wound dressing properties of sacran hydrogel film.

T. Higashi, K. Motoyama, H. Arima, 2017, International journal of biological macromolecules.

Efficient gene transfer to EGF receptor overexpressing cancer cells by means of EGF-labeled cationic liposomes.

H. Arima, Y. Aramaki, S. Tsuchiya, 1996, Biochemical and biophysical research communications.

Synthesis of multi-lactose-appended β-cyclodextrin and its cholesterol-lowering effects in Niemann–Pick type C disease-like HepG2 cells

T. Era, T. Higashi, K. Motoyama, 2017, Beilstein journal of organic chemistry.

Cholesterol lowering effects of mono-lactose-appended β-cyclodextrin in Niemann–Pick type C disease-like HepG2 cells

T. Era, T. Higashi, K. Motoyama, 2015, Beilstein journal of organic chemistry.

Effects of cyclodextrins on chemically and thermally induced unfolding and aggregation of lysozyme and basic fibroblast growth factor.

F. Hirayama, K. Uekama, H. Arima, 2006, Journal of pharmaceutical sciences.

Lactose-appended β-cyclodextrin as an effective nanocarrier for brain delivery.

Teruya Nakamura, T. Higashi, K. Motoyama, 2020, Journal of controlled release : official journal of the Controlled Release Society.

Potential Use of Thioalkylated Mannose-Modified Dendrimer (G3)/α-Cyclodextrin Conjugate as an NF-κB siRNA Carrier for the Treatment of Fulminant Hepatitis.

T. Higashi, K. Motoyama, H. Arima, 2015, Molecular pharmaceutics.

Specific inhibition of interleukin-10 production in murine macrophage-like cells by phosphorothioate antisense oligonucleotides.

H. Arima, Y. Aramaki, T. Sakamoto, 1998, Antisense & nucleic acid drug development.

Potential Use of Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for siRNA

T. Higashi, K. Motoyama, H. Arima, 2011, Pharmaceuticals.

Promising Use of Cyclodextrin-Based Non-Viral Vectors for Gene and Oligonucleotide Drugs

T. Higashi, K. Motoyama, H. Arima, 2018 .

Anti-allergic and Profilaggrin (ProFLG)-mRNA expression modulatory effects of sacran.

N. R. Ngatu, T. Higashi, K. Motoyama, 2017, International journal of biological macromolecules.

Preparation and evaluation of freeze dried surface-deacetylated chitin nanofiber/sacran pellets for use as an extended-release excipient.

K. Azuma, S. Ifuku, F. Hirayama, 2019, International journal of biological macromolecules.

Sacran, a High-molecular Weight Polysaccharide Inhibits Renal Injury and Oxidative Stress in Chronic Renal Failure Model Rats

T. Higashi, K. Motoyama, F. Hirayama, 2018, Journal of Nutritional Biology.

Inhibition of insulin amyloid fibril formation by cyclodextrins

H. Jono, H. Arima, Y. Ando, 2015, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.

Design of Potent Phosphorothioate Antisense Oligonucleotides Directed to Human Interleukin 10 Gene Product and Their Evaluation of Antisense Activity in U937 Cells

H. Arima, Y. Aramaki, T. Sakamoto, 1999, Pharmaceutical Research.

Improvement of Subcutaneous Bioavailability of Insulin by Sulphobutyl Ether β‐Cyclodextrin in Rats

S. Tajiri, F. Hirayama, K. Uekama, 2000, The Journal of pharmacy and pharmacology.

Effects of Selected Anionic β-Cyclodextrins on Persistence of Blood Glucose Lowering by Insulin Glargine after Subcutaneous Injection to Rats

T. Anno, T. Higashi, K. Motoyama, 2011, Journal of drug delivery.

Development of an apolipoprotein E mimetic peptide–lipid conjugate for efficient brain delivery of liposomes

Hidefumi Mukai, S. Fumoto, H. Arima, 2023, Drug delivery.

Recent Findings Concerning PAMAM Dendrimer Conjugates with Cyclodextrins as Carriers of DNA and RNA

Keiichi Motoyama, Hidetoshi Arima, K. Motoyama, 2009, Sensors.

Separation and Crystallization of Oleaginous Constituents in Cosmetics : Sweating and Blooming

H. Arima, M. Yamaguchi, H. Matsuda, 2001 .

Effects of aging on crystallization, dissolution and absorption characteristics of amorphous tolbutamide-2-hydroxypropyl-beta-cyclodextrin complex.

F. Hirayama, K. Uekama, H. Arima, 2000, Chemical & pharmaceutical bulletin.

Supramolecular Complex of Methyl-β-cyclodextrin with Adamantane-Grafted Hyaluronic Acid as a Novel Antitumor Agent.

T. Higashi, K. Motoyama, H. Arima, 2018, Chemical & pharmaceutical bulletin.

A plasma protein indistinguishable from ribosomal protein S19: conversion to a monocyte chemotactic factor by a factor XIIIa-catalyzed reaction on activated platelet membrane phosphatidylserine in association with blood coagulation.

H. Nishiura, Tetsurou Yamamoto, H. Arima, 2010, The American journal of pathology.

Effect of 2-Hydroxypropyl-β-cyclodextrin on Release Rate of Metoprolol from Ternary Metoprolol/2-hydroxypropyl-β-cyclodextrin/Ethylcellulose Tablets

F. Hirayama, K. Uekama, H. Arima, 2002 .

Potential use of polyamidoamine dendrimer/alpha-cyclodextrin conjugate (generation 3, G3) as a novel carrier for short hairpin RNA-expressing plasmid DNA.

F. Hirayama, K. Uekama, H. Arima, 2008, Journal of pharmaceutical sciences.

Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for DNA, shRNA and siRNA

T. Higashi, K. Motoyama, H. Arima, 2012, Pharmaceutics.

Improvement of gene delivery mediated by mannosylated dendrimer/α-cyclodextrin conjugates

Hidetoshi Arima, F. Hirayama, K. Uekama, 2005 .

Potential use of Folate-appended Methyl-β-Cyclodextrin as an Anticancer Agent

T. Higashi, K. Motoyama, H. Arima, 2013, Scientific Reports.

Epidermal growth factor in sacran hydrogel film accelerates fibroblast migration

H. Arima, A. N. Hasanah, T. Rusdiana, 2020, Journal of advanced pharmaceutical technology & research.

Design and Evaluation of the Highly Concentrated Human IgG Formulation Using Cyclodextrin Polypseudorotaxane Hydrogels

T. Higashi, K. Motoyama, H. Arima, 2015, AAPS PharmSciTech.

Possible enhancing mechanism of the cutaneous permeation of 4-biphenylylacetic acid by beta-cyclodextrin derivatives in hydrophilic ointment.

F. Hirayama, K. Uekama, H. Arima, 1996, Chemical & pharmaceutical bulletin.

Improvement of physicochemical stability of highly-concentrated antibodies using cyclodextrin polypseudorotaxane hydrogels

T. Higashi, K. Motoyama, H. Arima, 2016 .

Sustained Release System of siRNA Complex with Polyethyleneglycol-Appended -Cyclodextrin/Dendrimer Conjugate from Cyclodextrin Polypseudorotaxanes

Hayashida, K. Motoyama, H. Arima, 2017 .

Nanoparticles of folic acid‐methyl‐β‐cyclodextrin (FA‐MβCD)/adamantane‐albumin exhibit enhanced antitumor activity compared with FA‐MβCD alone

N. Kishimoto, T. Higashi, K. Motoyama, 2022, FEBS open bio.

Insulin receptor activation through its accumulation in lipid rafts by mild electrical stress

M. Suico, T. Shuto, Tomoaki Koga, 2013, Journal of cellular physiology.

[Anti-inflammatory Effect of Sacran on Atopic Dermatitis].

S. Fukushima, H. Ihn, T. Higashi, 2018, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Some Pharmaceutical Properties of a New Branched Cyclodextrin, 6-O-α-(4-O- α-D-Glucuronyl)-D-glucosylβ-cyclodextrin

F. Hirayama, K. Uekama, H. Arima, 2002 .

Design and Evaluation of Thioalkylated Mannose-Modified Dendrimer (G3)/α-Cyclodextrin Conjugates as Antigen-Presenting Cell-Selective siRNA Carriers

T. Higashi, K. Motoyama, H. Arima, 2014, The AAPS Journal.

In vitro and in vivo siRNA delivery to hepatocyte utilizing ternary complexation of lactosylated dendrimer/cyclodextrin conjugates, siRNA and low-molecular-weight sacran.

H. Jono, T. Higashi, K. Motoyama, 2018, International journal of biological macromolecules.

Ternary complexes of folate-PEG-appended dendrimer (G4)/α-cyclodextrin conjugate, siRNA and low-molecular-weight polysaccharide sacran as a novel tumor-selective siRNA delivery system.

T. Higashi, K. Motoyama, H. Arima, 2017, International journal of biological macromolecules.

Potential use of lactosylated dendrimer (G3)/α-cyclodextrin conjugates as hepatocyte-specific siRNA carriers for the treatment of familial amyloidotic polyneuropathy.

H. Jono, T. Higashi, K. Motoyama, 2012, Molecular pharmaceutics.

Inhibitory effect of siRNA complexes with polyamidoamine dendrimer/α-cyclodextrin conjugate (generation 3, G3) on endogenous gene expression.

T. Higashi, K. Motoyama, F. Hirayama, 2011, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Polypseudorotaxanes of pegylated insulin with cyclodextrins: application to sustained release system.

T. Higashi, F. Hirayama, K. Uekama, 2007, Bioorganic & medicinal chemistry letters.

WITHDRAWN: Tumor-targeting siRNA delivery utilizing of folate-PEG appended dendrimer (G4) conjugate with α-cyclodextrin

T. Higashi, K. Motoyama, H. Arima, 2015 .

Different solubilizing ability of cyclodextrin derivatives for cholesterol in Niemann–Pick disease type C treatment

K. Higaki, T. Higashi, K. Motoyama, 2023, Clinical and translational medicine.

Reply: lung toxicity of hydroxyl-β-cyclodextrin infusion.

H. Arima, T. Irie, M. Matsuo, 2013, Molecular genetics and metabolism.

Potential Use of Thioalkylated Mannose-Modified Dendrimer (G3)/α-Cyclodextrin Conjugate as an NF-κB siRNA Carrier for the Treatment of Fulminant Hepatitis.

T. Higashi, K. Motoyama, H. Arima, 2015, Molecular pharmaceutics.

Feasibility Study of Dendrimer-Based TTR-CRISPR pDNA Polyplex for Ocular Amyloidosis in Vitro.

H. Jono, T. Higashi, K. Motoyama, 2022, Biological & pharmaceutical bulletin.

Insulin receptor activation through its accumulation in lipid rafts by mild electrical stress

M. Suico, T. Shuto, Tomoaki Koga, 2013, Journal of cellular physiology.

Potential Use of Folate-polyethylene glycol (PEG)-Appended Dendrimer (G3) Conjugate with alpha-Cyclodextrin as DNA Carriers to Tumor Cells

T. Higashi, K. Motoyama, F. Hirayama, 2011, Nature Precedings.

Involvement of Autophagy in Antitumor Activity of Folate-appended Methyl-β-cyclodextrin

R. Kariya, S. Okada, T. Higashi, 2014, Scientific Reports.

K. Motoyama, F. Hirayama, K. Uekama, 2009, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

The Effects of Sacran, a Sulfated Polysaccharide, on Gut Microbiota Using Chronic Kidney Disease Model Rats.

Panayiotis D. Megaloikonomos, K. Azuma, T. Higashi, 2022, Biological & pharmaceutical bulletin.

[Potential Use of Sacran for Dermal and Oral Preparations].

T. Higashi, K. Motoyama, H. Arima, 2019, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Anti-allergic effects of novel sulfated polysaccharide sacran on mouse model of 2,4-Dinitro-1-fluorobenzene-induced atopic dermatitis.

T. Higashi, K. Motoyama, H. Arima, 2018, International journal of biological macromolecules.

Physically crosslinked-sacran hydrogel films for wound dressing application.

T. Higashi, K. Motoyama, H. Arima, 2016, International journal of biological macromolecules.

X-ray crystallographic characterization of nilvadipine monohydrate and its phase transition behavior.

F. Hirayama, K. Uekama, H. Arima, 2000, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.