J. Hanes

发表

Markedly enhanced skeletal muscle transfection achieved by the ultrasound-targeted delivery of non-viral gene nanocarriers with microbubbles.

A. Kim, Caitlin W. Burke, J. S. Suk, 2012, Journal of controlled release : official journal of the Controlled Release Society.

Quantifying the Intracellular Transport of Viral and Nonviral Gene Vectors in Primary Neurons

J. Suh, J. S. Suk, J. Hanes, 2007, Experimental biology and medicine.

Gene delivery to differentiated neurotypic cells with RGD and HIV Tat peptide functionalized polymeric nanoparticles.

J. Suh, J. S. Suk, J. Hanes, 2006, Biomaterials.

Efficient active transport of gene nanocarriers to the cell nucleus

D. Wirtz, J. Suh, J. Hanes, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Real-time quantitation of intracellular polycation/DNA nanocomplex transport: evidence for directed motion

D. Wirtz, J. Suh, J. Hanes, 2002, Proceedings of the Second Joint 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society] [Engineering in Medicine and Biology.

New degradable cationic polyesters for nonviral gene delivery

J. Hanes, Jie Fu, E. Krauland, 2002, Proceedings of the Second Joint 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society] [Engineering in Medicine and Biology.

Optimization of PEI/VEGF DNA polyplexes for potenital delivery from tissue engineering scaffolds

J. Hanes, Y. Har-el, J. H. van Zanten, 2002, Proceedings of the Second Joint 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society] [Engineering in Medicine and Biology.

Common Gene Therapy Viral Vectors Do Not Efficiently Penetrate Sputum from Cystic Fibrosis Patients

J. S. Suk, J. Hanes, S. Lai, 2011, PloS one.

Real-time multiple particle tracking of gene nanocarriers in complex biological environments.

Justin Hanes, Samuel K Lai, J. Hanes, 2008, Methods in molecular biology.

Real-time multiple-particle tracking: applications to drug and gene delivery.

Junghae Suh, Justin Hanes, J. Suh, 2005, Advanced drug delivery reviews.

Privileged delivery of polymer nanoparticles to the perinuclear region of live cells via a non-clathrin, non-degradative pathway.

Justin Hanes, Samuel K Lai, T. Schroer, 2007, Biomaterials.

Real‐time gene delivery vector tracking in the endo‐lysosomal pathway of live cells

Benjamin C. Tang, J. Suh, C. Dempsey, 2012, Microscopy research and technique.

Enhancement of airway gene transfer by DNA nanoparticles using a pH-responsive block copolymer of polyethylene glycol and poly-L-lysine.

A. Kim, J. S. Suk, J. Hanes, 2012, Biomaterials.

Real‐Time Intracellular Transport of Gene Nanocarriers Studied by Multiple Particle Tracking

Denis Wirtz, Junghae Suh, Justin Hanes, 2008, Biotechnology progress.

Barriers to inhaled gene therapy of obstructive lung diseases: A review.

Gregg A. Duncan, J. S. Suk, J. Hanes, 2016, Journal of controlled release : official journal of the Controlled Release Society.

Lung gene therapy with highly compacted DNA nanoparticles that overcome the mucus barrier.

Samuel K. Lai, Michael P. Boyle, Jung Soo Suk, 2014, Journal of controlled release : official journal of the Controlled Release Society.

Nanoparticles reveal that human cervicovaginal mucus is riddled with pores larger than viruses

Samuel K. Lai, Justin Hanes, J. Hanes, 2009, Proceedings of the National Academy of Sciences.

Mucoadhesive Nanoparticles May Disrupt the Protective Human Mucus Barrier by Altering Its Microstructure

Samuel K. Lai, Craig Schneider, Justin Hanes, 2011, PloS one.

A Dense Poly(Ethylene Glycol) Coating Improves Penetration of Large Polymeric Nanoparticles Within Brain Tissue

Elizabeth Nance, Justin Hanes, Qingguo Xu, 2012, Science Translational Medicine.

Mucus Penetrating Nanoparticles: Biophysical Tool and Method of Drug and Gene Delivery

J. S. Suk, J. Hanes, C. Schneider, 2012, Advanced materials.

Nanoparticle diffusion in respiratory mucus from humans without lung disease.

G. Woodworth, J. S. Suk, J. Hanes, 2013, Biomaterials.

Characterization of the intracellular dynamics of a non-degradative pathway accessed by polymer nanoparticles.

J. Hanes, S. Lai, Kaoru Hida, 2008, Journal of controlled release : official journal of the Controlled Release Society.

Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues.

J. Hanes, S. Lai, Ying-Ying Wang, 2009, Advanced drug delivery reviews.

Nano-structured glaucoma drainage implant safely and significantly reduces intraocular pressure in rabbits via post-operative outflow modulation

J. Hanes, L. Ensign, Kunal S Parikh, 2020, Scientific Reports.

Large porous particles for pulmonary drug delivery.

N Lotan, R. Langer, N. Lotan, 1997, Science.

N-acetylcysteine Enhances Cystic Fibrosis Sputum Penetration and Airway Gene Transfer by Highly Compacted DNA Nanoparticles.

Benjamin C. Tang, J. S. Suk, J. Hanes, 2011, Molecular therapy : the journal of the American Society of Gene Therapy.

N-acetylcysteine enhances cystic fibrosis sputum penetration and airway gene transfer by highly compacted DNA nanoparticles.

Benjamin C. Tang, J. S. Suk, J. Hanes, 2011, Molecular therapy : the journal of the American Society of Gene Therapy.

PEGylation as a strategy for improving nanoparticle-based drug and gene delivery.

Laura M Ensign, Jung Soo Suk, Justin Hanes, 2016, Advanced drug delivery reviews.

Paracrine immunotherapy with interleukin-2 and local chemotherapy is synergistic in the treatment of experimental brain tumors.

D. Brat, F. DiMeco, D. Pardoll, 1999, Cancer research.

Nanoparticle diffusion in, and microrheology of, the bovine vitreous ex vivo.

P. McDonnell, E. Duh, J. S. Suk, 2013, Journal of controlled release : official journal of the Controlled Release Society.

MRI-detectable pH nanosensors incorporated into hydrogels for in vivo sensing of transplanted cell viability

D. Arifin, J. Bulte, P. V. van Zijl, 2012, Nature materials.

Biotargeted nanomedicines for cancer: six tenets before you begin.

Russell J Mumper, Anil K Patri, Michael S. Goldberg, 2013, Nanomedicine.

Leukocyte-inspired biodegradable particles that selectively and avidly adhere to inflamed endothelium in vitro and in vivo

Aliasger K Salem, Justin Hanes, Mohammad F Kiani, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Biodegradable nanoparticles composed entirely of safe materials that rapidly penetrate human mucus.

Justin Hanes, Samuel K Lai, J. Hanes, 2011, Angewandte Chemie.

Impact of Surface Polyethylene Glycol (PEG) Density on Biodegradable Nanoparticle Transport in Mucus ex Vivo and Distribution in Vivo.

Xiaoqun Gong, Justin Hanes, Qingguo Xu, 2015, ACS nano.

Intraperitoneal delivery of paclitaxel by poly(ether-anhydride) microspheres effectively suppresses tumor growth in a murine metastatic ovarian cancer model

Benjamin C. Tang, C. Chuang, T. Wu, 2014, Drug Delivery and Translational Research.

Ensign Against Herpes Simplex Virus Mucus-Penetrating Nanoparticles for Vaginal Drug Delivery Protect

Benjamin C. Tang, J. Hanes, Ying-Ying Wang, 2012 .

Oral drug delivery with polymeric nanoparticles: the gastrointestinal mucus barriers.

Laura M Ensign, Justin Hanes, J. Hanes, 2012, Advanced drug delivery reviews.

Avoiding a Sticky Situation: Bypassing the Mucus Barrier for Improved Local Drug Delivery.

Hannah C. Zierden, J. Hanes, L. Ensign, 2021, Trends in molecular medicine.

Pseudomonas aeruginosa pyocyanin production reduced by quorum‐sensing inhibiting nanocarriers

Gregg A. Duncan, R. Prud’homme, J. S. Suk, 2018, International journal of pharmaceutics.

Mucus‐Penetrating Nanosuspensions for Enhanced Delivery of Poorly Soluble Drugs to Mucosal Surfaces

J. S. Suk, J. Hanes, S. Lai, 2016, Advanced healthcare materials.

Enema ion compositions for enhancing colorectal drug delivery.

C. Hendrix, J. Hanes, R. Cone, 2015, Journal of controlled release : official journal of the Controlled Release Society.

Effect of surface chemistry on nanoparticle interaction with gastrointestinal mucus and distribution in the gastrointestinal tract following oral and rectal administration in the mouse.

J. Hanes, R. Cone, L. Ensign, 2015, Journal of controlled release : official journal of the Controlled Release Society.

Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that "slip" through the human mucus barrier.

Jung Soo Suk, Justin Hanes, Samuel K Lai, 2008, Angewandte Chemie.

Rapid transport of muco-inert nanoparticles in cystic fibrosis sputum treated with N-acetyl cysteine.

J. S. Suk, J. Hanes, S. Lai, 2011, Nanomedicine.

Scalable method to produce biodegradable nanoparticles that rapidly penetrate human mucus.

J. Hanes, Nicholas J. Boylan, Qingguo Xu, 2013, Journal of controlled release : official journal of the Controlled Release Society.

Relating the phagocytosis of microparticles by alveolar macrophages to surface chemistry: the effect of 1,2-dipalmitoylphosphatidylcholine.

R. Langer, J. Hanes, R. Rogers, 1998, Journal of controlled release : official journal of the Controlled Release Society.

Targeted gene transfer to the brain via the delivery of brain-penetrating DNA nanoparticles with focused ultrasound.

J. S. Suk, A. Klibanov, J. Hanes, 2016, Journal of controlled release : official journal of the Controlled Release Society.

PEGylated enhanced cell penetrating peptide nanoparticles for lung gene therapy

Gregg A. Duncan, K. Shakesheff, J. Dixon, 2018, Journal of controlled release : official journal of the Controlled Release Society.

A theory of erosion and macromolecule release from biodegrading microspheres

R. Langer, J. Hanes, R. Batycky, 1997 .

New technology and clinical applications of nanomedicine: Highlights of the second annual meeting of the American Academy of Nanomedicine (Part I)

Shuming Nie, Hidezo Mori, Donald A Tomalia, 2006, Nanomedicine: Nanotechnology, Biology and Medicine.

Development of Absorbable, Antibiotic-Eluting Sutures for Ophthalmic Surgery

P. McDonnell, H. Mao, J. Hanes, 2017, Translational vision science & technology.

Sustained treatment of retinal vascular diseases with self-aggregating sunitinib microparticles

P. Campochiaro, J. Hanes, Jie Fu, 2020, Nature Communications.

Strategy to Enhance Dendritic Cell‐Mediated DNA Vaccination in the Lung

N. West, J. S. Suk, J. Hanes, 2020, Advanced therapeutics.

Non-degradative intracellular trafficking of highly compacted polymeric DNA nanoparticles.

A. Kim, J. S. Suk, J. Hanes, 2012, Journal of controlled release : official journal of the Controlled Release Society.

New polymeric carriers for controlled drug delivery following inhalation or injection.

J. Hanes, Jie Fu, E. Krauland, 2002, Biomaterials.

Upregulation of the Glutaminase II Pathway Contributes to Glutamate Production upon Glutaminase 1 Inhibition in Pancreatic Cancer

Arthur J. L. Cooper, J. Hanes, Jie Fu, 2019, Proteomics.

Controlled release of dexamethasone sodium phosphate with biodegradable nanoparticles for preventing experimental corneal neovascularization.

C. Eberhart, J. Hanes, B. Wang, 2019, Nanomedicine : nanotechnology, biology, and medicine.

Effects of enzymatic degradation on dynamic mechanical properties of the vitreous and intravitreal nanoparticle mobility

J. Hanes, Qingguo Xu, I. Rupenthal, 2018, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Controlled Local Delivery of Interleukin-2 by Biodegradable Polymers Protects Animals from Experimental Brain Tumors and Liver Tumors

M. Choti, D. Brat, F. DiMeco, 2001, Pharmaceutical Research.

MR image‐guided delivery of cisplatin‐loaded brain‐penetrating nanoparticles to invasive glioma with focused ultrasound

J. S. Suk, J. Hanes, R. Price, 2017, Journal of controlled release : official journal of the Controlled Release Society.

Hyaluronan in cervical epithelia protects against infection-mediated preterm birth.

J. Lydon, J. Hanes, L. Ensign, 2014, The Journal of clinical investigation.

Therapeutic effects of adipose-tissue-derived mesenchymal stromal cells and their extracellular vesicles in experimental silicosis

M. Paulaitis, J. S. Suk, J. Hanes, 2018, Respiratory Research.

Excess mucus viscosity and airway dehydration impact COPD airway clearance

G. Tearney, S. Birket, S. Rowe, 2019, European Respiratory Journal.

Inhaled gene therapy of preclinical muco-obstructive lung diseases by nanoparticles capable of breaching the airway mucus barrier

S. Birket, S. Rowe, J. S. Suk, 2021, Thorax.

A glycopolymer improves vascoelasticity and mucociliary transport of abnormal cystic fibrosis mucus.

K. Chu, G. Tearney, H. Leung, 2019, JCI insight.

Hypoxia-tropic Protein Nanocages for Modulation of Tumor- and Chemotherapy-Associated Hypoxia.

Seung Woo Chung, P. M. Hwang, J. Zhuang, 2018, ACS nano.

Sustained delivery of a HIF-1 antagonist for ocular neovascularization.

P. Campochiaro, G. Semenza, S. Connelly, 2013, Journal of controlled release : official journal of the Controlled Release Society.

Development of delivery methods for carbohydrate-based drugs: controlled release of biologically-active short chain fatty acid-hexosamine analogs

Benjamin C. Tang, M. A. Meledeo, Mark B. Jones, 2010, Glycoconjugate Journal.

Intracranial Paracrine Interleukin-2 Therapy Stimulates Prolonged Antitumor Immunity That Extends Outside the Central Nervous System

D. Brat, E. Jaffee, D. Pardoll, 2000, Journal of immunotherapy.

Drug carrier nanoparticles that penetrate human chronic rhinosinusitis mucus.

O. Mert, J. S. Suk, J. Hanes, 2011, Biomaterials.

Cellular uptake and intracellular transport of viral and non-viral gene vectors in differentiated neurons affected in Parkinson's Disease

J. Suh, J. S. Suk, J. Hanes, 2004 .

Characterization of an adapted murine model of intrauterine inflammation-induced preterm birth.

Hannah C. Zierden, J. Hanes, L. Ensign, 2019, The American journal of pathology.

Development of a mucoinert progesterone nanosuspension for safer and more effective prevention of preterm birth

J. Segars, Hannah C. Zierden, J. Hanes, 2019, Journal of controlled release : official journal of the Controlled Release Society.

Large Porous Particle Impingement on Lung Epithelial Cell Monolayers—Toward Improved Particle Characterization in the Lung

C. Ehrhardt, C. Lehr, J. Hanes, 2003, Pharmaceutical Research.

Drug absorption by the respiratory mucosa: cell culture models and particulate drug carriers.

C. Ehrhardt, J. Hanes, U. Schaefer, 2002, Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.

Corrigendum to “Real-time multiple-particle tracking: Applications to drug and gene delivery” [Advanced Drug Delivery Reviews 57(2005)63–78]

J. Suh, J. Hanes, Michelle R. Dawson, 2005 .

Scleral permeability varies by mouse strain and is decreased by chronic experimental glaucoma.

A. Kim, H. Quigley, E. Oglesby, 2014, Investigative ophthalmology & visual science.

Polymer microspheres for vaccine delivery.

R. Langer, J. Hanes, M. Chiba, 1995, Pharmaceutical biotechnology.

Development of rectal enema as microbicide (DREAM): Preclinical progressive selection of a tenofovir prodrug enema

E. Fuchs, C. Hendrix, M. Marzinke, 2019, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Chapter 5.1:Nanostructures for Overcoming the Pulmonary Barriers: Physiological Considerations and Mechanistic Issues

C. Lehr, J. Hanes, C. Schneider, 2012 .

Immunomodulation-accelerated neuronal regeneration following selective rod photoreceptor cell ablation in the zebrafish retina

Hongkai Ji, J. Hanes, Qingguo Xu, 2017, Proceedings of the National Academy of Sciences.

Preclinical Evaluation of Intravesical Cisplatin Nanoparticles for Non–Muscle-Invasive Bladder Cancer

A. Baras, D. McConkey, M. Kates, 2017, Clinical Cancer Research.

Brain Tumors Chemotherapy Is Synergistic in the Treatment of Experimental Paracrine Immunotherapy with Interleukin-2 and Local Updated

D. Brat, F. DiMeco, D. Pardoll, 2000 .

Corticosteroid-loaded biodegradable nanoparticles for prevention of corneal allograft rejection in rats.

Li Tang, D. Emmert, C. Eberhart, 2015, Journal of controlled release : official journal of the Controlled Release Society.

Human Immunodeﬁciency Virus Type 1 Is Trapped by Acidic but Not by Neutralized Human Cervicovaginal Mucus (cid:1) †

T. Hope, J. Hanes, S. Lai, 2009 .

DNA nanoparticle-mediated thymulin gene therapy prevents airway remodeling in experimental allergic asthma.

J. S. Suk, J. Hanes, Nicholas J. Boylan, 2014, Journal of controlled release : official journal of the Controlled Release Society.

Controlled release of corticosteroid with biodegradable nanoparticles for treating experimental autoimmune uveitis

E. Duh, C. Eberhart, J. Hanes, 2019, Journal of controlled release : official journal of the Controlled Release Society.

Sunitinib malate-loaded biodegradable microspheres for the prevention of corneal neovascularization in rats.

D. Emmert, C. Eberhart, J. Hanes, 2020, Journal of controlled release : official journal of the Controlled Release Society.

Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that "slip" through the human mucus barrier.

J. S. Suk, J. Hanes, S. Lai, 2008, Angewandte Chemie.

5th International Symposium on Focused Ultrasound

Matthew E. Downs, Gregory T. Clement, Chang Kyu Park, 2016, Journal of Therapeutic Ultrasound.

Novel Focused Ultrasound Gene Therapy Approach Noninvasively Restores Dopaminergic Neuron Function in a Rat Parkinson's Disease Model.

J. Hirsh, G. Miller, J. Mandell, 2017, Nano letters.

Sustained Dorzolamide Release Prevents Axonal and Retinal Ganglion Cell Loss in a Rat Model of IOP–Glaucoma

H. Quigley, E. Oglesby, M. Pease, 2017, Translational vision science & technology.

An Adeno-Associated Viral Vector Capable of Penetrating the Mucus Barrier to Inhaled Gene Therapy

Gregg A. Duncan, N. West, S. Birket, 2018, Molecular therapy. Methods & clinical development.

Biodegradable mucus-penetrating nanoparticles composed of diblock copolymers of polyethylene glycol and poly(lactic-co-glycolic acid)

O. Mert, J. Hanes, S. Lai, 2012, Drug Delivery and Translational Research.

Systematic assessment of microneedle injection into the mouse cornea

A. Jun, I. Bhutto, J. Hanes, 2012, European Journal of Medical Research.

Directed evolution for drug and nucleic acid delivery.

Marc Ostermeier, Justin Hanes, M. Ostermeier, 2007, Advanced drug delivery reviews.

Large-scale phenotypic drug screen identifies neuroprotectants in zebrafish and mouse models of retinitis pigmentosa

Jun O. Liu, D. Zack, Hongkai Ji, 2020, bioRxiv.

Cellular trafficking and anticancer activity of Garcinia mangostana extract-encapsulated polymeric nanoparticles

A. Kim, Porntip Pan-in, S. Wanichwecharungruang, 2014, International journal of nanomedicine.

The penetration of fresh undiluted sputum expectorated by cystic fibrosis patients by non-adhesive polymer nanoparticles.

Michael P Boyle, Laura M Ensign, Jung Soo Suk, 2009, Biomaterials.

Micro- and macrorheology of mucus.

Denis Wirtz, Justin Hanes, Samuel K Lai, 2009, Advanced Drug Delivery Reviews.

Gene Delivery to the Lung

J. Suh, J. Hanes, Y. Har-el, 2003 .

Nanoparticles for oral delivery: Design, evaluation and state-of-the-art.

Laura M Ensign, Justin Hanes, J. Hanes, 2016, Journal of controlled release : official journal of the Controlled Release Society.

Nanofiber-coated, tacrolimus-eluting sutures inhibit post-operative neointimal hyperplasia in rats.

N. Hibino, J. Hanes, L. Ensign, 2022, Journal of controlled release : official journal of the Controlled Release Society.

Gelling hypotonic polymer solution for extended topical drug delivery to the eye

P. Campochiaro, D. Zack, P. McDonnell, 2020, Nature Biomedical Engineering.

Subconjunctival Delivery of Dorzolamide-Loaded Poly(ether-anhydride) Microparticles Produces Sustained Lowering of Intraocular Pressure in Rabbits.

H. Quigley, J. Hanes, Jie Fu, 2016, Molecular pharmaceutics.

Ultra‐thin, high strength, antibiotic‐eluting sutures for prevention of ophthalmic infection

P. McDonnell, J. Hanes, L. Ensign, 2020, Bioengineering & translational medicine.

An ion‐paired moxifloxacin nanosuspension eye drop provides improved prevention and treatment of ocular infection

P. McDonnell, J. Hanes, L. Ensign, 2021, Bioengineering & translational medicine.

Validation of hyaluronic acid-agar-based hydrogels as vitreous humor mimetics for in vitro drug and particle migration evaluations.

Sachin S Thakur, J. Hanes, I. Rupenthal, 2020, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Nanofiber‐based glaucoma drainage implant improves surgical outcomes by modulating fibroblast behavior

Seung Woo Chung, J. Hanes, L. Ensign, 2023, Bioengineering & translational medicine.

Vaginal Delivery of Paclitaxel via Nanoparticles with Non‐Mucoadhesive Surfaces Suppresses Cervical Tumor Growth

Benjamin C. Tang, Chien-Fu Hung, Michael T McMahon, 2014, Advanced healthcare materials.

Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus

Justin Hanes, Samuel K Lai, J. Hanes, 2007, Proceedings of the National Academy of Sciences.

Nanoparticles that do not adhere to mucus provide uniform and long-lasting drug delivery to airways following inhalation

Benjamin C. Tang, J. S. Suk, J. Hanes, 2017, Science Advances.

Paracrine delivery of IL-12 against intracranial 9L gliosarcoma in rats.

D. Brat, M. Colombo, F. DiMeco, 2000, Journal of neurosurgery.

Hydroxyl PAMAM dendrimer-based gene vectors for transgene delivery to human retinal pigment epithelial cells.

R. Kannan, J. Hanes, E. Song, 2015, Nanoscale.

Altering Mucus Rheology to “Solidify” Human Mucus at the Nanoscale

Samuel K. Lai, Denis Wirtz, Justin Hanes, 2009, PloS one.

Protein nanocages that penetrate airway mucus and tumor tissue

Gregg A. Duncan, J. Zhuang, Xiaoyuan Chen, 2017, Proceedings of the National Academy of Sciences.

Emerging Insights into Barriers to Effective Brain Tumor Therapeutics

G. Dunn, G. Woodworth, H. Brem, 2014, Front. Oncol..

Microstructural alterations of sputum in cystic fibrosis lung disease.

Gregg A. Duncan, N. West, J. S. Suk, 2016, JCI insight.

Non-adhesive and highly stable biodegradable nanoparticles that provide widespread and safe transgene expression in orthotopic brain tumors

C. Eberhart, Shunyu Chen, J. S. Suk, 2020, Drug Delivery and Translational Research.

Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death

D. Zack, W. Hauswirth, S. Boye, 2013, Proceedings of the National Academy of Sciences.

Functional genomic screening identifies dual leucine zipper- bearing kinase as a therapeutic target in glaucoma

D. Zack, W. Hauswirth, S. Boye, 2013 .

The Mucus Barrier to Inhaled Gene Therapy.

Gregg A. Duncan, J. S. Suk, J. Hanes, 2016, Molecular therapy : the journal of the American Society of Gene Therapy.

Transport of metal oxide nanoparticles and single-walled carbon nanotubes in human mucus

S. Biswal, J. S. Suk, J. Hanes, 2012, Nanotoxicology.

Non-invasive delivery of stealth, brain-penetrating nanoparticles across the blood-brain barrier using MRI-guided focused ultrasound.

Elizabeth Nance, Ji Song, Justin Hanes, 2014, Journal of controlled release : official journal of the Controlled Release Society.

Enhanced efficacy of local etoposide delivery by poly(ether-anhydride) particles against small cell lung cancer in vivo.

Benjamin C. Tang, Justin Hanes, D Neil Watkins, 2010, Biomaterials.

Nance Polymeric Nanoparticles Within Brain Tissue A Dense Poly ( Ethylene Glycol ) Coating Improves Penetration of Large

Ting-Yu Shih, C. Eberhart, G. Woodworth, 2012 .

Fate of PEGylated antibody fragments following delivery to the lungs: Influence of delivery site, PEG size and lung inflammation

Gregg A. Duncan, J. S. Suk, J. Hanes, 2018, Journal of controlled release : official journal of the Controlled Release Society.

Biodegradable brain-penetrating DNA nanocomplexes and their use to treat malignant brain tumors.

J. S. Suk, J. Hanes, E. Song, 2017, Journal of controlled release : official journal of the Controlled Release Society.

Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer

Takashi Tsukamoto, Thomas Hartung, Justin Hanes, 2016, Proceedings of the National Academy of Sciences.

Enhancing Intracranial Delivery of Clinically Relevant Non-viral Gene Vectors.

J. S. Suk, J. Hanes, E. Song, 2016, RSC advances.

Nanoparticle-based drug delivery to the vagina: a review.

Laura M Ensign, Justin Hanes, J. Hanes, 2014, Journal of controlled release : official journal of the Controlled Release Society.

Minimizing the non-specific binding of nanoparticles to the brain enables active targeting of Fn14-positive glioblastoma cells.

A. Kim, J. Winkles, G. Woodworth, 2015, Biomaterials.

Mucus-Penetrating Nanoparticles for Vaginal Drug Delivery Protect Against Herpes Simplex Virus

Benjamin C. Tang, Laura M Ensign, Justin Hanes, 2012, Science Translational Medicine.

Degradation of porous poly(anhydride-co-imide) microspheres and implications for controlled macromolecule delivery.

R. Langer, J. Hanes, M Chiba, 1998, Biomaterials.

Particle-Tracking Microrheology Using Micro-Optical Coherence Tomography.

K. Chu, G. Tearney, S. Birket, 2016, Biophysical journal.

A functional anatomic defect of the cystic fibrosis airway.

Linbo Liu, William E Grizzle, Guillermo J Tearney, 2014, American journal of respiratory and critical care medicine.

Nanoparticle penetration of human cervicovaginal mucus: the effect of polyvinyl alcohol.

Justin Hanes, Samuel K Lai, J. Hanes, 2014, Journal of controlled release : official journal of the Controlled Release Society.

A poly(ethylene glycol)-based surfactant for formulation of drug-loaded mucus penetrating particles.

Justin Hanes, Samuel K Lai, O. Mert, 2012, Journal of controlled release : official journal of the Controlled Release Society.

Novel approaches to vaginal delivery and safety of microbicides: biopharmaceuticals, nanoparticles, and vaccines.

Robin Shattock, Justin Hanes, K. Whaley, 2010, Antiviral research.

Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier

Benjamin C. Tang, Michael P Boyle, Jung Soo Suk, 2009, Proceedings of the National Academy of Sciences.

Convection enhanced delivery of cisplatin‐loaded brain penetrating nanoparticles cures malignant glioma in rats

C. Eberhart, H. Brem, B. Tyler, 2017, Journal of controlled release : official journal of the Controlled Release Society.

Enhanced drug delivery to the reproductive tract using nanomedicine reveals therapeutic options for prevention of preterm birth

Günter P. Wagner, Hannah C. Zierden, J. Hanes, 2021, Science Translational Medicine.

Mucus-penetrating budesonide nanosuspension enema for local treatment of inflammatory bowel disease.

Xinglu Huang, Laura M Ensign, Justin Hanes, 2018, Biomaterials.

Targeting of dermal myofibroblasts through death receptor 5 arrests fibrosis in mouse models of scleroderma

Ami A. Shah, M. Horton, M. Pomper, 2019, Nature Communications.

Ion-Complex Microcrystal Formulation Provides Sustained Delivery of a Multimodal Kinase Inhibitor from the Subconjunctival Space for Protection of Retinal Ganglion Cells

D. Zack, H. Quigley, C. Eberhart, 2021, Pharmaceutics.

Single particle tracking reveals spatial and dynamic organization of the E. coli biofilm matrix.

P. Doyle, N. Billings, Alona Birjiniuk, 2014, New journal of physics.

Hypo-osmolar Formulation of Tenofovir (TFV) Enema Promotes Uptake and Metabolism of TFV in Tissues, Leading to Prevention of SHIV/SIV Infection

E. Fuchs, C. Hendrix, M. Marzinke, 2017, Antimicrobial Agents and Chemotherapy.

The cervicovaginal mucus barrier to HIV-1 is diminished in bacterial vaginosis

D. Kwon, Hannah C. Zierden, J. Hanes, 2020, PLoS pathogens.

A diaCEST MRI approach for monitoring liposomal accumulation in tumors.

K. Kinzler, B. Vogelstein, J. Bulte, 2014, Journal of controlled release : official journal of the Controlled Release Society.

Preclinical evaluation of a hypotonic docetaxel nanosuspension formulation for intravesical treatment of non-muscle-invasive bladder cancer

A. Baras, M. Rudek, M. Kates, 2020, Drug Delivery and Translational Research.

Focused Ultrasound Preconditioning for Augmented Nanoparticle Penetration and Efficacy in the Central Nervous System.

Colleen T. Curley, G. Miller, J. Mandell, 2019, Small.

Single particle tracking reveals spatial and dynamic organization of the Escherichia coli biofilm matrix

Elizabeth Nance, Patrick S Doyle, Justin Hanes, 2014 .

Molecularly defined cortical astroglia subpopulation modulates neurons via secretion of Norrin

Sean J. Miller, Raju Tomer, Malika S. Datta, 2019, Nature Neuroscience.

Local Immunotherapy with Interleukin-2 Delivered from Biodegradable Polymer Microspheres Combined with Interstitial Chemotherapy: A Novel Treatment for Experimental Malignant Glioma

A. Olivi, F. DiMeco, L. Rhines, 2003, Neurosurgery.

Controlled protein delivery from biodegradable tyrosine-containing poly(anhydride-co-imide) microspheres.

R. Langer, R. Langer, J. Hanes, 1997, Biomaterials.

Highly compacted pH-responsive DNA nanoparticles mediate transgene silencing in experimental glioma.

A. Kim, G. Woodworth, J. S. Suk, 2014, Journal of materials chemistry. B.

Brain-Penetrating Nanoparticles Improve Paclitaxel Efficacy in Malignant Glioma Following Local Administration

Ting-Yu Shih, J. Hanes, E. Nance, 2014, ACS nano.

Enhanced vaginal drug delivery through the use of hypotonic formulations that induce fluid uptake.

Laura M Ensign, J. Hanes, R. Cone, 2013, Biomaterials.

Human Immunodeficiency Virus Type 1 Is Trapped by Acidic but Not by Neutralized Human Cervicovaginal Mucus

T. Hope, J. Hanes, S. Lai, 2009, Journal of Virology.

Ion Channels and Transporters in Lung Function and Disease Combination therapy with cystic fibrosis transmembrane conductance regulator modulators augment the airway functional microanatomy

Linbo Liu, William E Grizzle, Guillermo J Tearney, 2016 .

Hypo-osmolar rectal douche tenofovir formulation prevents simian/human immunodeficiency virus acquisition in macaques

E. Fuchs, C. Hendrix, M. Marzinke, 2022, JCI insight.

Modulating Vibrio cholerae quorum-sensing-controlled communication using autoinducer-loaded nanoparticles.

B. Bassler, R. Prud’homme, J. Hanes, 2015, Nano letters.

Ex vivo characterization of particle transport in mucus secretions coating freshly excised mucosal tissues.

Laura M Ensign, Justin Hanes, Marc D. Porosoff, 2013, Molecular pharmaceutics.

Nanoparticle diffusion in spontaneously expectorated sputum as a biophysical tool to probe disease severity in COPD

V. Kim, N. Hansel, K. Carson, 2019, European Respiratory Journal.

The microstructure and bulk rheology of human cervicovaginal mucus are remarkably resistant to changes in pH.

J. Hanes, S. Lai, Ying-Ying Wang, 2013, Biomacromolecules.

Transport of Polymeric Nanoparticle Gene Carriers in Gastric Mucus

D. Wirtz, J. Hanes, E. Krauland, 2004, Biotechnology progress.

Enhanced Viscoelasticity of Human Cystic Fibrotic Sputum Correlates with Increasing Microheterogeneity in Particle Transport*

D. Wirtz, J. Hanes, Michelle R. Dawson, 2003, Journal of Biological Chemistry.

A hypotonic gel-forming eye drop provides enhanced intraocular delivery of a kinase inhibitor with melanin-binding properties for sustained protection of retinal ganglion cells

D. Zack, C. Eberhart, C. Berlinicke, 2021, Drug Delivery and Translational Research.

Uniform brain tumor distribution and tumor associated macrophage targeting of systemically administered dendrimers.

A. Olivi, Jinyuan Zhou, R. Kannan, 2015, Biomaterials.

Sustained delivery of acriflavine from the suprachoroidal space provides long term suppression of choroidal neovascularization.

P. Campochiaro, J. Hanes, Jie Fu, 2020, Biomaterials.

Cervicovaginal mucus barrier properties during pregnancy are impacted by the vaginal microbiome

Hannah C. Zierden, J. Hanes, S. Lai, 2023, Frontiers in Cellular and Infection Microbiology.

Particle tracking in drug and gene delivery research: State-of-the-art applications and methods.

Benjamin S Schuster, Laura M Ensign, Daniel B Allan, 2015, Advanced drug delivery reviews.

Overcoming the cystic fibrosis sputum barrier to leading adeno-associated virus gene therapy vectors.

A. Kim, N. Muzyczka, W. Guggino, 2014, Molecular therapy : the journal of the American Society of Gene Therapy.

Hyaluronic acid-conjugated lipoplexes for targeted delivery of siRNA in a murine metastatic lung cancer model.

S. Arpicco, J. S. Suk, J. Hanes, 2016, International journal of pharmaceutics.

Strategies to enhance the distribution of nanotherapeutics in the brain

C. Eberhart, J. S. Suk, J. Hanes, 2017, Journal of controlled release : official journal of the Controlled Release Society.

Liposome-based mucus-penetrating particles (MPP) for mucosal theranostics: demonstration of diamagnetic chemical exchange saturation transfer (diaCEST) magnetic resonance imaging (MRI).

M. McMahon, Kannie W. Y. Chan, J. Hanes, 2015, Nanomedicine : nanotechnology, biology, and medicine.

Widespread gene transfer to malignant gliomas with In vitro-to-In vivo correlation.

H. Mao, J. S. Suk, J. Hanes, 2019, Journal of controlled release : official journal of the Controlled Release Society.

Influence of apical fluid volume on the development of functional intercellular junctions in the human epithelial cell line 16HBE14o–: implications for the use of this cell line as an in vitro model for bronchial drug absorption studies

Carsten Kneuer, Claus-Michael Lehr, Kwang-Jin Kim, 2002, Cell and Tissue Research.

NanoDDS 2016: The 14th International Nanomedicine and Drug Delivery Symposium.

H. Cui, J. Hanes, 2017, Journal of controlled release : official journal of the Controlled Release Society.

Disulfide disruption reverses mucus dysfunction in allergic airway disease

Gregg A. Duncan, W. Janssen, D. Thornton, 2021, Nature Communications.

Disulfide disruption reverses mucus dysfunction in allergic airway disease

Gregg A. Duncan, W. Janssen, D. Thornton, 2019, bioRxiv.

Poly(ether-anhydride) dry powder aerosols for sustained drug delivery in the lungs.

J. Hanes, Jie Fu, J. Fiegel, 2004, Journal of controlled release : official journal of the Controlled Release Society.

Biodegradable DNA Nanoparticles that Provide Widespread Gene Delivery in the Brain.

J. S. Suk, J. Hanes, E. Song, 2016, Small.

Highly compacted biodegradable DNA nanoparticles capable of overcoming the mucus barrier for inhaled lung gene therapy

J. S. Suk, J. Hanes, M. Boyle, 2015, Proceedings of the National Academy of Sciences.

Machine learning-driven multifunctional peptide engineering for sustained ocular drug delivery

M. P. Cummings, J. Hanes, L. Ensign, 2023, Nature communications.

Enhanced adhesion of ligand‐conjugated biodegradable particles to colitic venules

J. Hanes, Jie Fu, D. J. Goetz, 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Polymeric particles conjugated with a ligand to VCAM‐1 exhibit selective, avid, and focal adhesion to sites of atherosclerosis

J. Hanes, Jie Fu, D. J. Goetz, 2008, Biotechnology and bioengineering.

Augmentation of brain tumor interstitial flow via focused ultrasound promotes brain-penetrating nanoparticle dispersion and transfection

Colleen T. Curley, G. Miller, J. Munson, 2020, Science Advances.

Molecularly defined cortical astroglia subpopulation modulates neurons via secretion of Norrin

Sean J. Miller, Raju Tomer, Malika S. Datta, 2019, Nature Neuroscience.

Nanoparticle-based thymulin gene therapy therapeutically reverses key pathology of experimental allergic asthma

J. S. Suk, J. Hanes, Namho Kim, 2020, Science Advances.

Nanoparticles coated with high molecular weight PEG penetrate mucus and provide uniform vaginal and colorectal distribution in vivo.

Laura M Ensign, Justin Hanes, Qingguo Xu, 2016, Nanomedicine.

PEGylation of nanoparticles improves their cytoplasmic transport

Benjamin C. Tang, Junghae Suh, Jung Soo Suk, 2007, International journal of nanomedicine.

Sustained treatment of retinal vascular diseases with self-aggregating sunitinib microparticles

P. Campochiaro, J. Hanes, Jie Fu, 2020, Nature Communications.

A theoretical model of erosion and macromolecular drug release from biodegrading microspheres.

R. Langer, J. Hanes, J Hanes, 1997, Journal of pharmaceutical sciences.

Systemic PEGylated TRAIL treatment ameliorates liver cirrhosis in rats by eliminating activated hepatic stellate cells

M. Pomper, Kwangmeyung Kim, Y. Byun, 2016, Hepatology.

Pretreatment of Human Cervicovaginal Mucus with Pluronic F127 Enhances Nanoparticle Penetration without Compromising Mucus Barrier Properties to Herpes Simplex Virus

Samuel K. Lai, Justin Hanes, O. Mert, 2014, Biomacromolecules.

A Highly Translatable Dual-arm Local Delivery Strategy To Achieve Widespread Therapeutic Coverage in Healthy and Tumor-bearing Brain Tissues.

B. Tyler, J. S. Suk, J. Hanes, 2023, Small.

Highly PEGylated DNA Nanoparticles Provide Uniform and Widespread Gene Transfer in the Brain

C. Eberhart, G. Woodworth, J. S. Suk, 2015, Advanced healthcare materials.

Use of single-site-functionalized PEG dendrons to prepare gene vectors that penetrate human mucus barriers.

Wojciech G. Lesniak, A. Kim, R. Kannan, 2013, Angewandte Chemie.

Highly compacted DNA nanoparticles with low MW PEG coatings: in vitro, ex vivo and in vivo evaluation.

J. S. Suk, J. Hanes, M. Cooper, 2012, Journal of controlled release : official journal of the Controlled Release Society.

Six-month effective treatment of corneal graft rejection

M. Rudek, J. Hanes, Qingguo Xu, 2023, Science advances.

Photoactivatable fluorescent probes reveal heterogeneous nanoparticle permeation through biological gels at multiple scales

J. Hanes, Benjamin S. Schuster, R. L. Leheny, 2017, Journal of controlled release : official journal of the Controlled Release Society.

Drug Delivery Research for the Future: Expanding the Nano Horizons and Beyond.

Samir Mitragotri, Ick Chan Kwon, Kinam Park, 2017, Journal of controlled release : official journal of the Controlled Release Society.

Non-covalent photo-patterning of gelatin matrices using caged collagen mimetic peptides.

Seungju M. Yu, Boi Hoa San, J. Hanes, 2015, Macromolecular bioscience.

The emergence of multiple particle tracking in intracellular trafficking of nanomedicines

A. Kim, J. Hanes, 2012, Biophysical Reviews.

Development of nintedanib nanosuspension for inhaled treatment of experimental silicosis

J. S. Suk, J. Hanes, M. Morales, 2022, Bioengineering & translational medicine.

From bench to bedside: successful translational nanomedicine: highlights of the Third Annual Meeting of the American Academy of Nanomedicine.

Raj Bawa, Nanhai Liu, Chiming Wei, 2007, Nanomedicine : nanotechnology, biology, and medicine.

Particulate matter in cigarette smoke increases ciliary axoneme beating through mechanical stimulation.

Diane S. Allen-Gipson, J. Hanes, E. Nance, 2012, Journal of aerosol medicine and pulmonary drug delivery.

Synthesis and Characterization of Degradable Anhydride-co-imide Terpolymers Containing Trimellitylimido-l-tyrosine: Novel Polymers for Drug Delivery

R. Langer, J. Hanes, M. Chiba, 1996 .

Parkinson's disease gene therapy: Will focused ultrasound and nanovectors be the next frontier?

J. Kordower, J. S. Suk, J. Hanes, 2019, Movement disorders : official journal of the Movement Disorder Society.

Self-assembling paclitaxel-mediated stimulation of tumor-associated macrophages for postoperative treatment of glioblastoma

Y. Guan, Rami W. Chakroun, Feihu Wang, 2023, Proceedings of the National Academy of Sciences of the United States of America.

Constitutive model development and micro-structural topology optimisation for Nafion hydrogel membranes with ionic clustering

H. P. Lee, Hua Li, Q. X. Wang, 2003, Journal of biomaterials science. Polymer edition.

A glycopolymer improves vascoelasticity and mucociliary transport of abnormal cystic fibrosis mucus.

Gareth W. Hughes, K. Chu, G. Tearney, 2019, JCI insight.

Barriers to inhaled gene therapy of obstructive lung diseases: A review.

Gregg A. Duncan, J. S. Suk, J. Hanes, 2016, Journal of controlled release : official journal of the Controlled Release Society.

Impact of Surface Polyethylene Glycol (PEG) Density on Biodegradable Nanoparticle Transport in Mucus ex Vivo and Distribution in Vivo.

E. Freire, A. Schön, J. Hanes, 2015, ACS nano.

Microstructural alterations of sputum in cystic fibrosis lung disease.

Gregg A. Duncan, N. West, J. S. Suk, 2016, JCI insight.

Systemic PEGylated TRAIL treatment ameliorates liver cirrhosis in rats by eliminating activated hepatic stellate cells

M. Pomper, Kwangmeyung Kim, Y. Byun, 2016, Hepatology.

Subconjunctival Delivery of Dorzolamide-Loaded Poly(ether-anhydride) Microparticles Produces Sustained Lowering of Intraocular Pressure in Rabbits.

H. Quigley, J. Hanes, Jie Fu, 2016, Molecular pharmaceutics.

Human Immunodeficiency Virus Type 1 Is Trapped by Acidic but Not by Neutralized Human Cervicovaginal Mucus

T. Hope, J. Hanes, S. Lai, 2009, Journal of Virology.

Model development and numerical simulation of electric-stimulus-responsive hydrogels subject to an externally applied electric field.

Jun Chen, H. P. Lee, Justin Hanes, 2004, Biosensors & bioelectronics.

Biodegradable mucus-penetrating nanoparticles composed of diblock copolymers of polyethylene glycol and poly(lactic-co-glycolic acid)

Samuel K. Lai, Craig Schneider, Justin Hanes, 2011, Drug Delivery and Translational Research.

Oral drug delivery with polymeric nanoparticles: the gastrointestinal mucus barriers.

J. Hanes, R. Cone, L. Ensign, 2012, Advanced drug delivery reviews.

Nanoparticles reveal that human cervicovaginal mucus is riddled with pores larger than viruses

J. Hanes, S. Lai, Kaoru Hida, 2009, Proceedings of the National Academy of Sciences.

Mucus-penetrating budesonide nanosuspension enema for local treatment of inflammatory bowel disease.

Hannah C. Zierden, Xinglu Huang, J. Hanes, 2018, Biomaterials.

PEGylation of nanoparticles improves their cytoplasmic transport

Benjamin C. Tang, J. Suh, J. S. Suk, 2007, International journal of nanomedicine.

Biodegradable brain-penetrating DNA nanocomplexes and their use to treat malignant brain tumors.

J. S. Suk, J. Hanes, E. Song, 2017, Journal of controlled release : official journal of the Controlled Release Society.

Wetting of a particle in a thin film.

J. Hanes, K. Stebe, J. Fiegel, 2005, Journal of colloid and interface science.

Bioreducible Gene Delivery Platform that Promotes Intracellular Payload Release and Widespread Brain Dispersion.

C. Eberhart, J. S. Suk, J. Hanes, 2023, ACS biomaterials science & engineering.

Highly PEGylated DNA Nanoparticles Provide Uniform and Widespread Gene Transfer in the Brain

C. Eberhart, G. Woodworth, J. S. Suk, 2015, Advanced healthcare materials.

Supramolecular Filament Hydrogel as a Universal Immunomodulator Carrier for Immunotherapy Combinations.

Caleb F. Anderson, Feihu Wang, H. Cui, 2023, ACS nano.

Synthesis and characterization of PEG-based ether-anhydride terpolymers: Novel polymers for controlled drug delivery

J. Hanes, Jie Fu, J. Fiegel, 2004 .

Sites in the AAV5 capsid tolerant to deletions and tandem duplications.

J. Chiorini, M. Ostermeier, J. Hanes, 2010, Archives of biochemistry and biophysics.

Engineered peptide-drug conjugate provides sustained protection of retinal ganglion cells with topical administration in rats.

J. Hanes, L. Ensign, Nicole M. Anders, 2023, Journal of controlled release : official journal of the Controlled Release Society.