J. Hughes

发表

Polymeric nanoparticles containing conjugated phospholipase A2 for nonviral gene delivery.

H. Le, Gururaj A. Rao, A. Hirko, 2010, Molecular pharmaceutics.

Evaluation of the transfection property of a peptide ligand for the fibroblast growth factor receptor as part of PEGylated polyethylenimine polyplex

Gururaj A. Rao, J. Hughes, R. Tsai, 2008 .

Rationally Designed Synthetic Vectors for Gene Delivery

Gururaj A. Rao, J. Hughes, Preeti Yadava, 2007 .

Polyethylenimine-mediated NGF gene delivery protects transected septal cholinergic neurons

M. King, E. Meyer, J. Hughes, 2004, Brain Research.

Adenovirus-Facilitated Nuclear Translocation of Adeno-Associated Virus Type 2

N. Muzyczka, P. Hearing, J. Hughes, 2002, Journal of Virology.

Evaluation of Adjuvants that Enhance the Effectiveness of Antisense Oligodeoxynucleotides

R. L. Juliano, J. Hughes, R. Juliano, 1996, Pharmaceutical Research.

Biodegradable pH-sensitive surfactants (BPS) in liposome-mediated nucleic acid cellular uptake and distribution.

J. Hughes, E. Liang, M. Rosenblatt, 2000, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Adeno-associated virus mediated gene transfer into primary rat brain neuronal and glial cultures: enhancement with the pH-sensitive surfactant dodecyl 2-(1′-imidazolyl) propionate

M. King, Samuel Wang, E. Meyer, 2000, Neurochemistry International.

Cationic Liposomes Containing Disulfide Bonds in Delivery of Plasmid DNA

Weiqi Wang, J. Hughes, F. Tang, 1999 .

Pre-exposure of cells to cationic lipids enhances transgene delivery and expression in a tissue culture cell line.

J. Simpkins, E. Meyer, J. Hughes, 1999, Journal of drug targeting.

Synthesis of a single-tailed cationic lipid and investigation of its transfection.

J. Hughes, F. Tang, 1999, Journal of controlled release : official journal of the Controlled Release Society.

Nuclear localization signal peptides enhance cationic liposome-mediated gene therapy.

J. Hughes, A. Aronsohn, A I Aronsohn, 1998, Journal of drug targeting.

Recombinant adeno-associated virus serotype 2 effectively transduces primary rat brain astrocytes and microglia.

M. King, C. Sumners, E. Meyer, 2004, Brain research. Brain research protocols.

In vitro transport and delivery of antisense oligonucleotides.

J. Hughes, R. Juliano, H. Yoo, 2000, Methods in enzymology.

In vitro cytotoxic activity of cationic paclitaxel nanoparticles on MDR-3T3 cells

J. Hughes, S. Sullivan, Guo-qin Niu, 2010, Journal of drug targeting.

Lipid membrane permeability of 2'-modified derivatives of phosphorothioate oligonucleotides.

P. D. Cook, J. Hughes, R. Juliano, 1994, Journal of pharmaceutical sciences.

Liposome Fluidity Alters Interactions Between the Ganglioside GM1 and Cholera Toxin B Subunit

J. Hughes, Preeti Yadava, Carlos Castro, 2008 .

In Vivo Anti-Tumor Effect of Expressing p14ARF-TAT Using a FGF2-Targeted Cationic Lipid Vector

W. Driessen, J. Hughes, S. Sullivan, 2011, Pharmaceutical Research.

Antimicrobial activities of human beta-defensins against Bacillus species.

J. Hughes, Preeti Yadava, Chun Zhang, 2006, International journal of antimicrobial agents.

M. King, E. Meyer, J. Hughes, 2006, Experimental Neurology.

Nucleic Acid Cellular Delivery

J. Hughes, Preeti Yadava, Wu Xiao, 2004 .

Effect of Lyophilization and Freeze-thawing on the Stability of siRNA-liposome Complexes

J. Hughes, Preeti Yadava, M. Gibbs, 2008, AAPS PharmSciTech.

The Effect of Lyophilization on Plasmid DNA Activity

J. Hughes, S. Poxon, Scott W. Poxon, 2000, Pharmaceutical development and technology.

Dendrimer Delivery of Oligonucleotides

J. Hughes, E. Liang, S. Poxon, 1996 .

AAV2/5-mediated NGF gene delivery protects septal cholinergic neurons following axotomy

M. King, E. Meyer, J. Hughes, 2005, Brain Research.

Sulfhydryl Based Cationic Surfactants and the Impact of Polyanions on Disulfide Bond Formation: Implications for Gene Transfer Vectors

J. Hughes, Preeti Yadava, Anupama Khanna, 2004, Journal of drug targeting.

3β [N-(N′, N′-Dimethylaminoethane)-Carbamoyl] Cholesterol (DC-Chol)-Mediated Gene Delivery to Primary Rat Neurons: Characterization and Mechanism

J. Hughes, P. Ajmani, 1999, Neurochemical Research.

Characterization of a pH-sensitive surfactant, dodecyl-2-(1'-imidazolyl) propionate (DIP), and preliminary studies in liposome mediated gene transfer.

J. Hughes, E. Liang, 1998, Biochimica et biophysica acta.

Genetically engineered vaccines.

J. Hughes, G. Brazeau, 1995, American pharmacy.

Expression of the cloned coliphage T3 S-adenosylmethionine hydrolase gene inhibits DNA methylation and polyamine biosynthesis in Escherichia coli

J. Hughes, L. R. Brown, A. J. Ferro, 1987, Journal of bacteriology.

Uptake and efflux of intact antisense phosphorothioate deoxyoligonucleotide directed against angiotensin receptors in bovine adrenal cells

J. Hughes, M. Phillips, Bing Li, 1997, Neurochemistry International.

Cationic lipid vectors for plasmid DNA delivery.

A. Hirko, J. Hughes, F. Tang, 2003, Current medicinal chemistry.

Introduction of a disulfide bond into a cationic lipid enhances transgene expression of plasmid DNA.

J. Hughes, F. Tang, 1998, Biochemical and biophysical research communications.

Preparation of [11C]formaldehyde using a hollow fiber membrane bioreactor.

J. Hughes, M. Jay, 1995, Nuclear medicine and biology.

Activity of alkaline phosphatase bound to polysulfone membranes

D. Bhattacharyya, J. Hughes, M. Jay, 1991 .

In Situ Gel Formulations for Gene Delivery: Release and Myotoxicity Studies

J. Hughes, G. Brazeau, F. Ismail, 2000, Pharmaceutical development and technology.

Influence of base composition on membrane binding and cellular uptake of 10-mer phosphorothioate oligonucleotides in Chinese hamster ovary (CHRC5) cells.

J. Hughes, R. Juliano, A. Avrutskaya, 1994, Antisense research and development.

In Vitro Myotoxicity of Selected Cationic Macromolecules Used in Non-Viral Gene Delivery

J. Hughes, G. Brazeau, S. Attia, 1998, Pharmaceutical Research.

A Novel Piggyback Strategy for mRNA Delivery Exploiting Adenovirus Entry Biology

D. Curiel, L. Aulisa, Ernst Wagner, 2022, Viruses.

Transgene Delivery with a Cationic Lipid in the Presence of Amyloid β (βAP) Peptide

M. King, E. Meyer, J. Hughes, 2001, Neurochemical Research.

Multiple calcium channels and kinases mediate α7 nicotinic receptor neuroprotection in PC12 cells

R. Papke, E. Meyer, J. Hughes, 2005, Journal of neurochemistry.

Preparation of [11C]‐thymidine and [11C]‐2′‐arabino‐2′‐fluoro‐β‐5‐methyl‐uridine (FMAU) using a hollow fiber membrane bioreactor system

J. Hughes, N. Hartman, M. Jay, 1995 .

In vivo hydrolysis of S-adenosylmethionine induces the met regulon of Escherichia coli.

J. Hughes, Bernadette L LaMonte, 2006, Microbiology.

A Novel Method for Polymer Coating of Plasmid DNA: Initial Investigations into the Use of Pulse Laser Deposition and Gene Delivery

J. Hughes, G. Hochhaus, J. Talton, 2004, Journal of drug targeting.

Kinetic modeling of plasmid DNA degradation in rat plasma

B. Houk, J. Hughes, G. Hochhaus, 1999, AAPS PharmSci.

Pharmacokinetics of Plasmid DNA in the Rat

B. Houk, J. Hughes, G. Hochhaus, 2004, Pharmaceutical Research.

Radiolabeling of Methylphosphonate and Phosphorothioate Oligonucleotides and Evaluation of Their Transport in Everted Rat Jejunum Sacs

K. Brouwer, E. Wickstrom, J. Hughes, 1995, Pharmaceutical Research.

Infection of the macrophage cell line NR8383 with Mycobacterium tuberculosis (H37Ra) leads to an increase in oligodeoxynucleotide accumulation.

J. Hughes, M. Rosenblatt, J. Burns, 2000, Antisense & nucleic acid drug development.

RELATIONSHIP BETWEEN PLASMID DNA TOPOLOGICAL FORMS AND IN VITRO TRANSFECTION

J. Hughes, Pattravadee Chancham, 2001, Journal of liposome research.

Use of disulfide cationic lipids in plasmid DNA delivery.

J. Hughes, F. Tang, 2001, Methods in molecular medicine.

Enhanced transgene expression in rat brain cell cultures with a disulfide-containing cationic lipid

C. Sumners, E. Meyer, J. Hughes, 1999, Neuroscience Letters.

Liposomal siRNA delivery.

J. Hughes, Preeti Yadava, Ryan Mesaros, 2010, Methods in molecular biology.

Evaluation of two cationic delivery systems for siRNA.

J. Hughes, D. Roura, Preeti Yadava, 2007, Oligonucleotides.

Evaluation of the transfection property of a peptide ligand for the fibroblast growth factor receptor as part of PEGylated polyethylenimine polyplex.

Gururaj A. Rao, J. Hughes, R. Tsai, 2008, Journal of drug targeting.

Preparation and characterization of doxorubicin liposomes.

J. Hughes, Guo-qin Niu, B. Cogburn, 2010, Methods in molecular biology.

Long-term neuronal effects and disposition of ectopic preproNGF gene transfer into the rat septum.

W. Millard, M. King, E. Meyer, 2003, Human gene therapy.

DQAsomes: A Novel Potential Drug and Gene Delivery System Made from Dequalinium™

V. Weissig, J. Hughes, G. Erdos, 1998, Pharmaceutical Research.

Plasmid Delivery in the Rat Brain

E. Meyer, A. Hirko, J. Hughes, 2002, Bioscience reports.

Surface properties, more than size, limiting convective distribution of virus-sized particles and viruses in the central nervous system.

E. Oldfield, J. Hughes, Jeongwu Lee, 2005, Journal of neurosurgery.

Use of dithiodiglycolic acid as a tether for cationic lipids decreases the cytotoxicity and increases transgene expression of plasmid DNA in vitro.

J. Hughes, F. Tang, 1999, Bioconjugate chemistry.

Analysis of Host Cells Associated with the Spv-Mediated Increased Intracellular Growth Rate of Salmonella typhimurium in Mice

J. Hughes, H. Matsui, P. Gulig, 1998, Infection and Immunity.

Acetylated low-density lipoprotein-encapsulated cholesteryl 1,3-diiopanoate glyceryl ether for the detection of atherosclerosis in rabbits.

J. Hughes, T. Scott, Liping Feng, 2003, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Membrane Fusion and Rupture in Liposomes: Effect of Biodegradable pH-Sensitive Surfactants

J. Hughes, E. Liang, 1998, The Journal of Membrane Biology.

Alpha 1-antitrypsin therapy mitigated ischemic stroke damage in rats.

M. King, M. Grant, A. Hirko, 2014, Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.

The role of LPCAT in regulating cellular inflammatory responses to toll-like receptor ligands

J. Hughes, 2014 .

Insulin-Like Growth Factor Binding Protein-3 Mediates Vascular Repair by Enhancing Nitric Oxide Generation

M. Boulton, T. Lyons, S. Li Calzi, 2009, Circulation research.

Foam fractionation as a method to separate endotoxin from recombinant biotechnology products.

J. Hughes, S. Poxon, 1999, PDA journal of pharmaceutical science and technology.

Membrane fluidity effects of estratrienes

J. Simpkins, L. Prokai, J. Hughes, 2001, Brain Research Bulletin.

Antimicrobial activities of human β-defensins against Bacillus species

J. Hughes, Preeti Yadava, Chun Zhang, 2006 .

The protective effects of plasma gelsolin on stroke outcome in rats

M. King, M. Grant, H. Le, 2011, Experimental & Translational Stroke Medicine.

Interaction of oligodeoxynucleotides with mycobacteria: implications for new therapeutic strategies.

J. Hughes, M. Rosenblatt, S. Attia, 1998, Antisense & nucleic acid drug development.

Dose and Promoter Effects of Adeno-Associated Viral Vector for Green Fluorescent Protein Expression in the Rat Brain

M. King, Samuel Wang, E. Meyer, 2002, Experimental Neurology.

Transgene delivery with a cationic lipid in the presence of amyloid beta (betaAP) peptide.

M. King, E. Meyer, J. Hughes, 2001, Neurochemical research.

Characterization of endotoxin and cationic liposome interaction.

J. Hughes, S. Poxon, 1999, Pharmaceutical development and technology.

A gene delivery approach for antimicrobials: Expression of defensins

J. Hughes, Preeti Yadava, Chun Zhang, 2006, Journal of drug targeting.

Nucleic acid-matrix attachment recognition regions--as facilitators in plasmid transfer.

J. Hughes, P. Chancham, I. Mcdoom, 2003, Journal of drug targeting.