T. Ishida

发表

Complexation of siRNA and pDNA with cationic liposomes: the important aspects in lipoplex preparation.

J. Barichello, T. Ishida, H. Kiwada, 2010, Methods in molecular biology.

Anti-MUC-1 immunoliposomal doxorubicin in the treatment of murine models of metastatic breast cancer.

T. Ishida, E. Moase, W. Qi, 2001, Biochimica et biophysica acta.

Anti-PEG IgM production by siRNA encapsulated in a PEGylated lipid nanocarrier is dependent on the sequence of the siRNA.

T. Ishida, H. Kiwada, T. Tagami, 2011, Journal of controlled release : official journal of the Controlled Release Society.

CpG motifs in pDNA-sequences increase anti-PEG IgM production induced by PEG-coated pDNA-lipoplexes.

N. Yamazaki, T. Ishida, H. Kiwada, 2010, Journal of controlled release : official journal of the Controlled Release Society.

Cell type-specific gene expression, mediated by TFL-3, a cationic liposomal vector, is controlled by a post-transcription process of delivered plasmid DNA.

Xinyu Wang, T. Ishida, H. Kiwada, 2004, International journal of pharmaceutics.

Interactions of liposomes with cells in vitro and in vivo: opsonins and receptors.

H. Harashima, T. Ishida, H. Kiwada, 2001, Current drug metabolism.

Liposome Clearance

H. Harashima, T. Ishida, H. Kiwada, 2002, Bioscience reports.

Use of the Post-Insertion Technique to Insert Peptide Ligands into Pre-Formed Stealth Liposomes with Retention of Binding Activity and Cytotoxicity

R. Gaspar, T. Ishida, T. Allen, 2002, Pharmaceutical Research.

Tumor targeting of doxorubicin by anti-MT1-MMP antibody-modified PEG liposomes.

H. Harashima, H. Akita, H. Hatakeyama, 2007, International journal of pharmaceutics.

Agitation during lipoplex formation improves the gene knockdown effect of siRNA.

N. Oku, T. Asai, J. Barichello, 2011, International journal of pharmaceutics.

Agitation during lipoplex formation harmonizes the interaction of siRNA to cationic liposomes.

L. Soares, J. Barichello, T. Ishida, 2012, International journal of pharmaceutics.

Preparation of an Ultrafine Rebamipide Ophthalmic Suspension with High Transparency.

T. Ishida, Takakuni Matsuda, Shogo Hiraoka, 2017, Biological & pharmaceutical bulletin.

Downregulation of thymidylate synthase by RNAi molecules enhances the antitumor effect of pemetrexed in an orthotopic malignant mesothelioma xenograft mouse model.

M. Fukushima, H. Wada, C. Kato, 2016, International journal of oncology.

Sequential administration with oxaliplatin-containing PEG-coated cationic liposomes promotes a significant delivery of subsequent dose into murine solid tumor.

T. Ishida, H. Kiwada, Kazuya Nakamura, 2010, Journal of controlled release : official journal of the Controlled Release Society.

Characteristics of unique endocytosis induced by weak current for cytoplasmic drug delivery.

N. Yamazaki, K. Kogure, T. Ishida, 2019, International journal of pharmaceutics.

Particle size-dependent triggering of accelerated blood clearance phenomenon.

M. Yokoyama, N. Oku, Hiroyuki Koide, 2008, International journal of pharmaceutics.

Complement activation induced by PEG enhances humoral immune responses against antigens encapsulated in PEG-modified liposomes.

T. Ishida, Taro Shimizu, H. Ando, 2020, Journal of controlled release : official journal of the Controlled Release Society.

Accelerated blood clearance (ABC) phenomenon upon repeated injection of PEGylated liposomes.

T. Ishida, H. Kiwada, 2008, International journal of pharmaceutics.

Unexpected Reactions by In Vivo Applications of PEGylated Liposomes

T. Ishida, H. Kiwada, 2009 .

Development of pH-sensitive liposomes that efficiently retain encapsulated doxorubicin (DXR) in blood.

T. Ishida, H. Kiwada, Y. Okada, 2006, International journal of pharmaceutics.

Effect of cationic liposomes in an in vitro transcription and translation system.

Y. Baba, Y. Shinohara, H. Harashima, 2002, Biological & pharmaceutical bulletin.

Alteration of tumor microenvironment for improved delivery and intratumor distribution of nanocarriers.

T. Ishida, H. Kiwada, 2013, Biological & pharmaceutical bulletin.

Application of polyglycerol coating to plasmid DNA lipoplex for the evasion of the accelerated blood clearance phenomenon in nucleic acid delivery.

T. Ishida, H. Kiwada, Y. Uehara, 2014, Journal of pharmaceutical sciences.

The accelerated blood clearance (ABC) phenomenon: clinical challenge and approaches to manage.

T. Ishida, H. Kiwada, A. S. Abu Lila, 2013, Journal of controlled release : official journal of the Controlled Release Society.

Use of polyglycerol (PG), instead of polyethylene glycol (PEG), prevents induction of the accelerated blood clearance phenomenon against long-circulating liposomes upon repeated administration.

T. Ishida, H. Kiwada, Taro Shimizu, 2013, International journal of pharmaceutics.

Influence of the physicochemical properties of liposomes on the accelerated blood clearance phenomenon in rats.

T. Ishida, H. Kiwada, Xinyu Wang, 2005, Journal of controlled release : official journal of the Controlled Release Society.

Thioredoxin-albumin fusion protein prevents copper enhanced zinc-induced neurotoxicity via its antioxidative activity.

M. Kawahara, T. Ishida, M. Otagiri, 2018, International journal of pharmaceutics.

Design, preparation and directional insertion of peptides into lipid bilayer membrane and their application for the preparation of liposome of which surface could be coated by externally added antibody

T. Matsuo, N. Yamazaki, Y. Shinohara, 2007, 2007 International Symposium on Micro-NanoMechatronics and Human Science.

Mutant coat proteins of Pf3 bacteriophage as models of membrane proteins and their interactions with lipid bilayer membrane

T. Matsuo, N. Yamazaki, Y. Shinohara, 2006, 2006 IEEE International Symposium on MicroNanoMechanical and Human Science.

The contribution of phagocytic activity of liver macrophages to the accelerated blood clearance (ABC) phenomenon of PEGylated liposomes in rats.

T. Ishida, H. Kiwada, Syuntaro Kashima, 2008, Journal of controlled release : official journal of the Controlled Release Society.

Spleen plays an important role in the induction of accelerated blood clearance of PEGylated liposomes.

T. Ishida, H. Kiwada, Xinyu Wang, 2006, Journal of controlled release : official journal of the Controlled Release Society.

The accelerated clearance on repeated injection of pegylated liposomes in rats: laboratory and histopathological study.

T. Ishida, H. Kiwada, M. Ichihara, 2002, Cellular & molecular biology letters.

A Photo-Activatable Peptide Mimicking Functions of Apolipoprotein A-I.

A. Otaka, T. Ishida, Akira Shigenaga, 2019, Biological & pharmaceutical bulletin.

Inducing effect of liposomalization on the transdermal delivery of hydrocortisone: creation of a drug supersaturated state.

T. Ishida, H. Kiwada, H. Handa, 2006, Journal of controlled release : official journal of the Controlled Release Society.

Chemistry, Properties, and in Vitro and in Vivo Applications of 2′‐O‐Methoxyethyl‐4′‐thioRNA, a Novel Hybrid Type of Chemically Modified RNA

N. Minakawa, A. Matsuda, N. Yamazaki, 2014, Chembiochem : a European journal of chemical biology.

Quantitative evaluation of the intratumoral distribution of platinum in oxaliplatin‐treated rectal cancer: In situ visualization of platinum via synchrotron radiation X‐ray fluorescence spectrometry

Masafumi Nakamura, Y. Oda, K. Nitta, 2020, International journal of cancer.

Long-term storage of PEGylated liposomal oxaliplatin with improved stability and long circulation times in vivo.

T. Ishida, Taro Shimizu, Y. Ishima, 2019, International journal of pharmaceutics.

Liposomalization of oxaliplatin exacerbates the non-liposomal formulation-induced decrease of sweet taste sensitivity in rats.

T. Ishida, Taro Shimizu, H. Ando, 2021, Journal of pharmaceutical sciences.

Liposomalization of oxaliplatin induces skin accumulation of it, but negligible skin toxicity

T. Ishida, H. Ando, K. Nagasawa, 2017, Toxicology and applied pharmacology.

Oxaliplatin encapsulated in PEG-coated cationic liposomes induces significant tumor growth suppression via a dual-targeting approach in a murine solid tumor model.

T. Ishida, H. Kiwada, S. Kizuki, 2009, Journal of controlled release : official journal of the Controlled Release Society.

Abrogation of the accelerated blood clearance phenomenon by SOXL regimen: promise for clinical application.

T. Ishida, H. Kiwada, A. S. Abu Lila, 2013, International journal of pharmaceutics.

Combination therapy of metronomic S‐1 dosing with oxaliplatin‐containing polyethylene glycol‐coated liposome improves antitumor activity in a murine colorectal tumor model

T. Ishida, H. Kiwada, Yusuke Doi, 2010, Cancer science.

Co‐administration of liposomal l‐OHP and PEGylated TS shRNA‐lipoplex: A novel approach to enhance anti‐tumor efficacy and reduce the immunogenic response to RNAi molecules

M. Fukushima, H. Wada, T. Ishida, 2017, Journal of controlled release : official journal of the Controlled Release Society.

Improved intratumoral delivery of PEG-coated siRNA-lipoplexes by combination with metronomic S-1 dosing in a murine solid tumor model

M. Matsunaga, T. Ishida, H. Kiwada, 2012, Drug Delivery and Translational Research.

S‐Nitrosated alpha‐1‐acid glycoprotein exhibits antibacterial activity against multidrug‐resistant bacteria strains and synergistically enhances the effect of antibiotics

T. Ishida, M. Otagiri, T. Kuroda, 2019, FASEB bioAdvances.

Improvement of intratumor microdistribution of PEGylated liposome via tumor priming by metronomic S-1 dosing

T. Ishida, Taro Shimizu, A. S. Abu Lila, 2016, International journal of nanomedicine.

Liposome co-incubation with cancer cells secreted exosomes (extracellular vesicles) with different proteins expressions and different uptake pathways

T. Ishida, Taro Shimizu, H. Ando, 2018, Scientific Reports.

Neutralization of Acidic Tumor Microenvironment (TME) with Daily Oral Dosing of Sodium Potassium Citrate (K/Na Citrate) Increases Therapeutic Effect of Anti-cancer Agent in Pancreatic Cancer Xenograft Mice Model.

T. Ishida, H. Ando, K. Eshima, 2021, Biological & pharmaceutical bulletin.

I.p.-injected cationic liposomes are retained and accumulate in peritoneally disseminated tumors

T. Ishida, Taro Shimizu, H. Ando, 2021, Journal of Controlled Release.

Tumor-type-dependent vascular permeability constitutes a potential impediment to the therapeutic efficacy of liposomal oxaliplatin.

T. Ishida, H. Kiwada, A. S. Abu Lila, 2012, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Multiple administration of PEG-coated liposomal oxaliplatin enhances its therapeutic efficacy: a possible mechanism and the potential for clinical application.

T. Ishida, H. Kiwada, Noha Essam Eldin, 2012, International journal of pharmaceutics.

Using Bio-Layer Interferometry to Evaluate Anti-PEG Antibody-Mediated Complement Activation.

T. Ishida, Taro Shimizu, H. Ando, 2022, Biological & pharmaceutical bulletin.

Increased gene expression by cationic liposomes (TFL-3) in lung metastases following intravenous injection.

N. Oku, T. Ishida, H. Kiwada, 2005, Biological & pharmaceutical bulletin.

Lidocaine self-sacrificially improves the skin permeation of the acidic and poorly water-soluble drug etodolac via its transformation into an ionic liquid.

T. Ishida, Y. Miwa, H. Hamamoto, 2016, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Hepatic Tumor Metastases Cause Enhanced PEGylated Liposome Uptake by Kupffer Cells.

T. Ishida, Taro Shimizu, H. Ando, 2016, Biological & pharmaceutical bulletin.

Subvisible particles derived by dropping stress enhance anti-PEG antibody production and clearance of PEGylated proteins in mice.

Y. Tsutsumi, Yuka Fukuda, T. Ishida, 2022, Journal of pharmaceutical sciences.

Systemically Administered RNAi Molecule Sensitizes Malignant Pleural Mesotheliomal Cells to Pemetrexed Therapy.

M. Fukushima, H. Wada, T. Ishida, 2016, Molecular pharmaceutics.

Advanced therapeutic approach for the treatment of malignant pleural mesothelioma via the intrapleural administration of liposomal pemetrexed.

C. Kato, K. Kawazoe, T. Ishida, 2015, Journal of controlled release : official journal of the Controlled Release Society.

Pegfilgrastim (PEG-G-CSF) induces anti-PEG IgM in a dose dependent manner and causes the accelerated blood clearance (ABC) phenomenon upon repeated administration in mice.

T. Ishida, Taro Shimizu, H. Ando, 2020, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Lysophosphatidic acid in medicinal herbs enhances prostaglandin E2 and protects against indomethacin-induced gastric cell damage in vivo and in vitro.

Shiro Watanabe, K. Kogure, T. Ishida, 2018, Prostaglandins & other lipid mediators.

Anti-PEG IgM production and accelerated blood clearance phenomenon after the administration of PEGylated exosomes in mice.

T. Ishida, Taro Shimizu, H. Ando, 2021, Journal of controlled release : official journal of the Controlled Release Society.

Doxorubicin Expands in Vivo Secretion of Circulating Exosome in Mice.

T. Ishida, Taro Shimizu, H. Ando, 2018, Biological & pharmaceutical bulletin.

Immunoliposomal drug-delivery system targeting lectin-like oxidized low-density lipoprotein receptor-1 for carotid plaque lesions in rats.

T. Tominaga, M. Fujimura, T. Ishida, 2011, Journal of neurosurgery.

The complement system enhances the clearance of phosphatidylserine (PS)-liposomes in rat and guinea pig.

H. Harashima, T. Ishida, H. Kiwada, 2001, International journal of pharmaceutics.

Anti-PEG IgM and complement system are required for the association of second doses of PEGylated liposomes with splenic marginal zone B cells.

T. Ishida, H. Kiwada, Taro Shimizu, 2015, Immunobiology.

Development of a Nanocarrier-Based Splenic B Cell-Targeting System for Loading Antigens in Vitro.

T. Ishida, Taro Shimizu, H. Ando, 2022, Biological & pharmaceutical bulletin.

The Therapeutic Effect of Human Serum Albumin Dimer-Doxorubicin Complex against Human Pancreatic Tumors

T. Ishida, Taro Shimizu, H. Ando, 2021, Pharmaceutics.

A Novel Platform for Cancer Vaccines: Antigen-Selective Delivery to Splenic Marginal Zone B Cells via Repeated Injections of PEGylated Liposomes

G. Storm, T. Ishida, Taro Shimizu, 2018, The Journal of Immunology.

Utilization of click chemistry to study the effect of poly(ethylene)glycol molecular weight on the self-assembly of PEGylated gambogic acid nanoparticles for the treatment of rheumatoid arthritis.

T. Ishida, Shyh-Dar Li, H. Ando, 2020, Biomaterials science.

Blood retention and antigenicity of polycarboxybetaine-modified liposomes.

A. Kishimura, Takeshi Mori, Y. Katayama, 2020, International journal of pharmaceutics.

The Co-Delivery of Oxaliplatin Abrogates the Immunogenic Response to PEGylated siRNA-Lipoplex

T. Ishida, H. Kiwada, Naoto Moriyoshi, 2013, Pharmaceutical Research.

Intratumoral Visualization of Oxaliplatin within a Liposomal Formulation Using X-ray Fluorescence Spectrometry.

N. Yagi, Y. Terada, T. Ishida, 2018, Molecular pharmaceutics.

Albumin domain mutants with enhanced Aβ binding capacity identified by phage display analysis for application in various peripheral Aβ elimination approaches of Alzheimer's disease treatment

H. Morioka, T. Ishida, M. Otagiri, 2019, IUBMB life.

Ex-vivo/in-vitro anti-polyethylene glycol (PEG) immunoglobulin M production from murine splenic B cells stimulated by PEGylated liposome.

T. Ishida, H. Kiwada, Taro Shimizu, 2013, Biological & pharmaceutical bulletin.

Anti-PEG IgM production via a PEGylated nano-carrier system for nucleic acid delivery.

T. Ishida, H. Kiwada, Naoto Moriyoshi, 2013, Methods in molecular biology.

CORRELATIONS BETWEEN THE RATE OF INTRACELLULAR RELEASE OF ENDOCYTOSED LIPOSOMAL DOXORUBICIN AND CYTOTOXICITY AS DETERMINED BY A NEW ASSAY

T. Ishida, T. Allen, M. Kirchmeier, 2001, Journal of liposome research.

Lymphoid follicle antigen (Ag) delivery and enhanced rodent humoral immune responses mediated by Ag-containing PEGylated liposomes.

T. Ishida, Taro Shimizu, H. Ando, 2021, Vaccine.

Activation of TLR9 by incorporated pDNA within PEG-coated lipoplex enhances anti-PEG IgM production

T. Ishida, H. Kiwada, Y. Uehara, 2014, Gene Therapy.

Incorporating Gangliosides into PEGylated Cationic Liposomes that Complexed DNA Attenuates Anti-PEG Antibody Production but Not Anti-DNA Antibody Production in Mice.

T. Ishida, Taro Shimizu, H. Ando, 2021, Molecular pharmaceutics.

A Novel Strategy to Increase the Yield of Exosomes (Extracellular Vesicles) for an Expansion of Basic Research.

T. Ishida, Taro Shimizu, H. Ando, 2018, Biological & pharmaceutical bulletin.

Polyethylene glycol (PEG): The nature, immunogenicity, and role in the hypersensitivity of PEGylated products.

T. Ishida, Taro Shimizu, H. Ando, 2022, Journal of controlled release : official journal of the Controlled Release Society.

Neuroprotection by intrathecal application of liposome-entrapped fasudil in a rat model of ischemia.

T. Ishida, T. Allen, A. Shuaib, 2001, Neurologia medico-chirurgica.

Quantitative determination of polysulfide in albumins, plasma proteins and biological fluid samples using a novel combined assays approach.

M. Xian, T. Akaike, T. Ishida, 2017, Analytica chimica acta.

Human serum albumin hydropersulfide is a potent reactive oxygen species scavenger in oxidative stress conditions such as chronic kidney disease.

T. Abe, T. Ishida, M. Otagiri, 2016, Biochemical and biophysical research communications.

Wnt2b and Wnt5a expression in tumor and stromal cells in M2 and M1 TAMs and Ki‐67 proliferation index in 160 consecutive patients with resected non‐small cell lung cancer

H. Date, T. Ishida, H. Ando, 2022 .

Cell-penetrating mechanism of intracellular targeting albumin: Contribution of macropinocytosis induction and endosomal escape.

S. Futaki, T. Ishida, Taro Shimizu, 2019, Journal of controlled release : official journal of the Controlled Release Society.

Establishment of an X-ray Irradiation-Induced Glossitis Model in Rats: Biphasic Elevation of Proinflammatory Cytokines and Chemokines

M. Shibamori, T. Ishida, Takako Nakashima, 2013, The Journal of Pharmacology and Experimental Therapeutics.

Distribution of Polysulfide in Human Biological Fluids and Their Association with Amylase and Sperm Activities

T. Akaike, T. Ishida, Taro Shimizu, 2019, Molecules.

Immunological responses to PEGylated proteins

T. Ishida, A. S. Abu Lila, Nehal E. Elsadek, 2020 .

PEG shedding-rate-dependent blood clearance of PEGylated lipid nanoparticles in mice: faster PEG shedding attenuates anti-PEG IgM production.

T. Ishida, K. Yamazaki, Yuta Suzuki, 2020, International journal of pharmaceutics.

Gene Silencing Using 4′-thioDNA as an Artificial Template to Synthesize Short Hairpin RNA Without Inducing a Detectable Innate Immune Response

N. Minakawa, T. Ishida, H. Ando, 2016, Molecular therapy. Nucleic acids.

Evasion of the accelerated blood clearance phenomenon by coating of nanoparticles with various hydrophilic polymers.

T. Ishida, H. Kiwada, T. Maeda, 2010, Biomacromolecules.

Lactoferrin inhibits platelet production from human megakaryocytes in vitro.

T. Ishida, H. Kiwada, T. Taki, 2008, Biological & pharmaceutical bulletin.

Novel submicronized rebamipide liquid with moderate viscosity: significant effects on oral mucositis in animal models.

T. Ishida, Takako Nakashima, Naoya Uematsu, 2014, Biological & pharmaceutical bulletin.

Oral administration of sodium bicarbonate can enhance the therapeutic outcome of Doxil® via neutralizing the acidic tumor microenvironment.

T. Ishida, Taro Shimizu, H. Ando, 2022, Journal of controlled release : official journal of the Controlled Release Society.

Safe and efficient drug delivery system with liposomes for intrathecal application of an antivasospastic drug, fasudil.

T. Ishida, H. Kiwada, Y. Takanashi, 2006, Biological & pharmaceutical bulletin.

A simplified method for manufacturing RNAi therapeutics for local administration.

M. Fukushima, H. Wada, T. Ishida, 2019, International journal of pharmaceutics.

Intrathecal application with liposome-entrapped Fasudil for cerebral vasospasm followingsubarachnoid hemorrhage in rats

John H. Zhang, T. Ishida, T. Allen, 2001, Journal of Clinical Neuroscience.

A mouse model for studying the effect of blood anti-PEG IgMs levels on the in vivo fate of PEGylated liposomes.

T. Ishida, Taro Shimizu, H. Ando, 2022, International journal of pharmaceutics.

Modulation of antitumor immunity contributes to the enhanced therapeutic efficacy of liposomal oxaliplatin in mouse model

T. Ishida, Taro Shimizu, H. Ando, 2017, Cancer science.

A novel S-sulfhydrated human serum albumin preparation suppresses melanin synthesis

T. Ishida, Taro Shimizu, M. Otagiri, 2017, Redox biology.

Metronomic S-1 dosing and thymidylate synthase silencing have synergistic antitumor efficacy in a colorectal cancer xenograft model.

M. Fukushima, H. Wada, T. Ishida, 2017, Cancer letters.

Effect of Co-administration of Tacrolimus on the Pharmacokinetics of Multiple Subcutaneous Administered Interferon-Alpha in Rats

M. Odomi, T. Ishida, H. Kiwada, 2009, Pharmaceutical Research.

Accelerated blood clearance of PEGylated liposomes containing doxorubicin upon repeated administration to dogs.

T. Ishida, H. Kiwada, H. Kikuchi, 2012, International journal of pharmaceutics.

Pegfilgrastim (PEG-G-CSF) Induces Anti-polyethylene Glycol (PEG) IgM via a T Cell-Dependent Mechanism.

T. Ishida, Taro Shimizu, A. S. Abu Lila, 2020, Biological & pharmaceutical bulletin.

Importance of Process Parameters Influencing the Mean Diameters of siRNA-Containing Lipid Nanoparticles (LNPs) on the in Vitro Activity of Prepared LNPs.

T. Ishida, Kazuya Nakamura, Keisuke Aihara, 2022, Biological & pharmaceutical bulletin.

[Accelerated blood clearance (ABC) phenomenon induced by administration of PEGylated liposome].

T. Ishida, H. Kiwada, 2008, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

An immediate hypersensitivity reaction induced by PEGylated recombinant factor VIII

T. Ishida, Taro Shimizu, A. Morimoto, 2020, Haemophilia : the official journal of the World Federation of Hemophilia.

Efficient construction of the hexacyclic ring core of palau'amine: the pKa concept for proceeding with unfavorable equilibrium reactions

T. Ishida, K. Namba, Sherif E. Emam, 2021, Chemical science.

Co-administration of tacrolimus suppresses pharmacokinetic modulation of multiple subcutaneously administered human interferon-alpha in Beagle dogs.

M. Odomi, T. Ishida, H. Kiwada, 2010, Drug metabolism and pharmacokinetics.

Liposomal Delivery Systems: Design Optimization and Current Applications.

T. Ishida, A. S. Abu Lila, 2017, Biological & pharmaceutical bulletin.

First-in-human phase 1 trial of hemoglobin vesicles as artificial red blood cells developed for use as a transfusion alternative

H. Azuma, T. Ishida, Taro Shimizu, 2022, Blood Advances.

Effect of transferrin receptor-targeted liposomal doxorubicin in P-glycoprotein-mediated drug resistant tumor cells.

Hideyoshi Harashima, H. Harashima, T. Ishida, 2007, International journal of pharmaceutics.

PEGylated liposomes: immunological responses

J. Szebeni, T. Ishida, Taro Shimizu, 2019, Science and technology of advanced materials.

Anti-PEG antibodies: Properties, formation and role in adverse immune reactions to PEGylated nano-biopharmaceuticals.

J. Szebeni, T. Ishida, Taro Shimizu, 2020, Advanced drug delivery reviews.

Impact of pre-existing or induced anti-PEG IgM on the pharmacokinetics of peginterferon alfa-2a (Pegasys®) in mice.

T. Ishida, Taro Shimizu, A. S. Abu Lila, 2020, Molecular pharmaceutics.

Anti-PEG IgM Is a Major Contributor to the Accelerated Blood Clearance of Polyethylene Glycol-Conjugated Protein.

T. Ishida, H. Kiwada, Taro Shimizu, 2015, Molecular pharmaceutics.

PEGylated liposomes elicit an anti-PEG IgM response in a T cell-independent manner.

Taro Shimizu, Xinyu Wang, T. Ishida, 2007, Journal of controlled release : official journal of the Controlled Release Society.

Combined effect of liposomalization and addition of glycerol on the transdermal delivery of isosorbide 5-nitrate in rat skin.

T. Ishida, H. Kiwada, H. Handa, 2008, International journal of pharmaceutics.

An RNAi therapeutic, DFP-10825, for intraperitoneal and intrapleural malignant cancers.

T. Ishida, Hidenori Ando, 2020, Advanced drug delivery reviews.

Anti-angiogenic therapy via cationic liposome-mediated systemic siRNA delivery.

M. Matsunaga, T. Ishida, H. Kiwada, 2012, International journal of pharmaceutics.

Argonaute2 is a potential target for siRNA-based cancer therapy for HT1080 human fibrosarcoma

N. Yamazaki, N. Oku, T. Asai, 2011, Drug Delivery and Translational Research.

Global Gene Expression Profiling in Cultured Cells Is Strongly Influenced by Treatment with siRNA–Cationic Liposome Complexes

T. Ishida, H. Kiwada, T. Tagami, 2008, Pharmaceutical Research.

Disappearance of the angiogenic potential of endothelial cells caused by Argonaute2 knockdown.

Tomohiro Asai, Naoto Oku, J. Yokota, 2008, Biochemical and biophysical research communications.

Anti-PEG IgM elicited by injection of liposomes is involved in the enhanced blood clearance of a subsequent dose of PEGylated liposomes.

T. Ishida, H. Kiwada, Xinyu Wang, 2007, Journal of controlled release : official journal of the Controlled Release Society.

A double-modulation strategy in cancer treatment with a chemotherapeutic agent and siRNA.

M. Matsunaga, T. Ishida, H. Kiwada, 2011, Molecular therapy : the journal of the American Society of Gene Therapy.

The gene-silencing effect of siRNA in cationic lipoplexes is enhanced by incorporating pDNA in the complex.

T. Ishida, H. Kiwada, H. Kikuchi, 2007, International journal of pharmaceutics.

Improved anticancer effects of albumin-bound paclitaxel nanoparticle via augmentation of EPR effect and albumin-protein interactions using S-nitrosated human serum albumin dimer.

H. Maeda, T. Ishida, Taro Shimizu, 2017, Biomaterials.

Pharmaceutics of Nanoparticles

T. Ishida, Taro Shimizu, Masami Ukawa, 2016 .

Metronomic chemotherapy and nanocarrier platforms.

T. Ishida, A. S. Abu Lila, 2017, Cancer letters.

Gene expression analysis during platelet-like particle production in phorbol myristate acetate-treated MEG-01 cells.

T. Ono, Takuma Kawakami, T. Ishida, 2009, Biological & pharmaceutical bulletin.

Accelerated clearance of a second injection of PEGylated liposomes in mice.

T. Ishida, H. Kiwada, Tatsuhiro Ishida, 2003, International journal of pharmaceutics.

Accelerated clearance of PEGylated liposomes in rats after repeated injections.

T. Ishida, H. Kiwada, Tatsuhiro Ishida, 2003, Journal of controlled release : official journal of the Controlled Release Society.

Aseptic meningitis after vaccination of the BNT162b2 mRNA COVID-19 vaccine

T. Ishida, Taro Shimizu, K. Suzuki-Inoue, 2021, Neurological Sciences.

Influence of dose and animal species on accelerated blood clearance of PEGylated liposomal doxorubicin.

T. Ishida, H. Kiwada, H. Kikuchi, 2014, International journal of pharmaceutics.

Selective delivery of oxaliplatin to tumor tissue by nanocarrier system enhances overall therapeutic efficacy of the encapsulated oxaliplatin.

T. Ishida, H. Kiwada, A. Lila, 2014, Biological & pharmaceutical bulletin.

Oxaliplatin targeting to angiogenic vessels by PEGylated cationic liposomes suppresses the angiogenesis in a dorsal air sac mouse model.

T. Ishida, H. Kiwada, Yusuke Doi, 2009, Journal of controlled release : official journal of the Controlled Release Society.

Recent advances in tumor vasculature targeting using liposomal drug delivery systems

T. Ishida, H. Kiwada, A. S. Abu Lila, 2009, Expert opinion on drug delivery.

Adjuvant Antitumor Immunity Contributes to the Overall Antitumor Effect of Pegylated Liposomal Doxorubicin (Doxil®) in C26 Tumor-Bearing Immunocompetent Mice

T. Ishida, Taro Shimizu, Y. Ishima, 2020, Pharmaceutics.

Suppression of immune response by antigen-modified liposomes encapsulating model agents: a novel strategy for the treatment of allergy.

N. Oku, T. Asai, T. Ishida, 2013, Journal of controlled release : official journal of the Controlled Release Society.

Indocyanine green‐labeled dasatinib as a new fluorescent probe for molecular imaging of gastrointestinal stromal tumors

T. Takayama, T. Ishida, K. Okamoto, 2020, Journal of gastroenterology and hepatology.

In vitro efficacy of a sterically stabilized immunoliposomes targeted to membrane type 1 matrix metalloproteinase (MT1-MMP).

Hideo Kobayashi, Takanori Aoki, Hiroshi Kikuchi, 2007, Biological & pharmaceutical bulletin.

The New Delivery Strategy of Albumin Carrier Utilizing the Interaction with Albumin Receptors.

T. Ishida, M. Otagiri, T. Maruyama, 2022, Chemical & pharmaceutical bulletin.

Reactivity of IgM antibodies elicited by PEGylated liposomes or PEGylated lipoplexes against auto and foreign antigens

T. Ishida, Taro Shimizu, A. S. Abu Lila, 2018, Journal of controlled release : official journal of the Controlled Release Society.

A combinatorial approach to producing sterically stabilized (Stealth) immunoliposomal drugs

T. Ishida, T. Allen, Debbie L Iden, 1999, FEBS letters.

Sequential treatment of oxaliplatin-containing PEGylated liposome together with S-1 improves intratumor distribution of subsequent doses of oxaliplatin-containing PEGylated liposome.

T. Ishida, H. Kiwada, A. S. Abu Lila, 2014, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Synergistic antitumor activity of metronomic dosing of cyclophosphamide in combination with doxorubicin-containing PEGylated liposomes in a murine solid tumor model.

T. Ishida, H. Kiwada, Emi Shiraga, 2009, Journal of controlled release : official journal of the Controlled Release Society.

Targeted delivery and triggered release of liposomal doxorubicin enhances cytotoxicity against human B lymphoma cells.

T. Ishida, E. Moase, T. Allen, 2001, Biochimica et biophysica acta.

Increasing Tumor Extracellular pH by an Oral Alkalinizing Agent Improves Antitumor Responses of Anti-PD-1 Antibody: Implication of Relationships between Serum Bicarbonate Concentrations, Urinary pH, and Therapeutic Outcomes.

T. Ishida, Taro Shimizu, K. Eshima, 2021, Biological & pharmaceutical bulletin.

Targeting Anticancer Drugs to Tumor Vasculature Using Cationic Liposomes

T. Ishida, H. Kiwada, A. S. Abu Lila, 2010, Pharmaceutical Research.

HEPC-based liposomes trigger cytokine release from peripheral blood cells: effects of liposomal size, dose and lipid composition.

M. Muraguchi, T. Ishida, H. Kiwada, 2002, International journal of pharmaceutics.

Stimulatory effect of polyethylene glycol (PEG) on gene expression in mouse liver following hydrodynamics‐based transfection

T. Ishida, H. Kiwada, Wenhao Li, 2006, The journal of gene medicine.

FTY720 Reduces Lipid Accumulation by Upregulating ABCA1 through Liver X Receptor and Sphingosine Kinase 2 Signaling in Macrophages

T. Ishida, Taro Shimizu, Y. Ishima, 2022, International journal of molecular sciences.

A metronomic schedule of cyclophosphamide combined with PEGylated liposomal doxorubicin has a highly antitumor effect in an experimental pulmonary metastatic mouse model.

T. Ishida, H. Kiwada, J. M. Barichello, 2008, International journal of pharmaceutics.

Involvement of complement activation in the pulmonary vasoactivity of polystyrene nanoparticles in pigs: unique surface properties underlying alternative pathway activation and instant opsonization

T. Mészáros, Y. Barenholz, J. Szebeni, 2018, International journal of nanomedicine.

Immune Response to PEGylated Nanomedicines: Impact of IgM Response

T. Ishida, A. Lila, 2018 .

Complex formation with plasmid DNA increases the cytotoxicity of cationic liposomes.

T. Ishida, H. Kiwada, J. M. Barichello, 2007, Biological & pharmaceutical bulletin.

Wnt2b and Wnt5a expression is highly associated with M2 TAMs in non-small cell lung cancer

H. Date, T. Ishida, Ryota Sumitomo, 2022, Oncology reports.

Encapsulation of an antivasospastic drug, fasudil, into liposomes, and in vitro stability of the fasudil-loaded liposomes.

T. Ishida, H. Kiwada, I. Yamamoto, 2002, International journal of pharmaceutics.

Efficient gene expression in megakaryocytic cell line using nucleofection.

T. Ishida, H. Kiwada, T. Taki, 2007, International journal of pharmaceutics.

Liposome co-incubation with cancer cells secreted exosomes (extracellular vesicles) with different proteins expressions and different uptake pathways

T. Ishida, Taro Shimizu, M. Mahdy, 2018, Scientific Reports.

Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes.

T. Ishida, H. Kiwada, Xinyu Wang, 2006, Journal of controlled release : official journal of the Controlled Release Society.

Accelerated blood clearance of PEGylated liposomes upon repeated injections: effect of doxorubicin-encapsulation and high-dose first injection.

T. Ishida, H. Kiwada, Tatsuhiro Ishida, 2006, Journal of controlled release : official journal of the Controlled Release Society.

Relationship between the concentration of anti-polyethylene glycol (PEG) immunoglobulin M (IgM) and the intensity of the accelerated blood clearance (ABC) phenomenon against PEGylated liposomes in mice.

T. Ishida, H. Kiwada, Taro Shimizu, 2015, Biological & pharmaceutical bulletin.

Accelerated blood clearance of PEGylated liposomes following preceding liposome injection: effects of lipid dose and PEG surface-density and chain length of the first-dose liposomes.

Xin Yu Wang, T. Ishida, H. Kiwada, 2005, Journal of controlled release : official journal of the Controlled Release Society.

Nitrite is an alternative source of NO in vivo.

Michiyo Shikishima, M. Yoshizumi, T. Tamaki, 2005, American journal of physiology. Heart and circulatory physiology.

Encapsulation in a rapid-release liposomal formulation enhances the anti-tumor efficacy of pemetrexed in a murine solid mesothelioma-xenograft model.

K. Kawazoe, T. Ishida, Noha Essam Eldin, 2016, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Investigation of anti-PEG antibody response to PEG-containing cosmetic products in mice.

T. Ishida, Taro Shimizu, A. Hussein, 2023, Journal of controlled release : official journal of the Controlled Release Society.

Evidence for Delivery of Abraxane via a Denatured-Albumin Transport System.

T. Ishida, Taro Shimizu, V. Chuang, 2021, ACS applied materials & interfaces.

A Maleimide-Terminally Modified PEGylated Liposome Induced the Accelerated Blood Clearance Independent of the Production of Anti-PEG IgM Antibodies.

T. Ishida, Taro Shimizu, V. Chuang, 2022, Biological & pharmaceutical bulletin.

Reduction-Responsive and Multidrug Deliverable Albumin Nanoparticles: An Antitumor Drug to Abraxane against Human Pancreatic Tumor-Bearing Mice

T. Ishida, Taro Shimizu, M. Otagiri, 2021 .

Optimized PEGylated adenovirus vector reduces the anti-vector humoral immune response against adenovirus and induces a therapeutic effect against metastatic lung cancer.

Y. Yoshioka, S. Nakagawa, H. Mizuguchi, 2010, Biological & pharmaceutical bulletin.

Intravenous administration of polyethylene glycol-coated (PEGylated) proteins and PEGylated adenovirus elicits an anti-PEG immunoglobulin M response.

Y. Yoshioka, S. Nakagawa, T. Ishida, 2012, Biological & pharmaceutical bulletin.

[Development of drug delivery system for intrathecal administration and its therapeutic effect on cerebral vasospasm and ischemia].

T. Ishida, 2004, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Doxorubicin Embedded into Nanofibrillated Bacterial Cellulose (NFBC) Produces a Promising Therapeutic Outcome for Peritoneally Metastatic Gastric Cancer in Mice Models via Intraperitoneal Direct Injection

K. Tajima, T. Ishida, Taro Shimizu, 2021, Nanomaterials.

Therapeutic efficacy of a paclitaxel-loaded nanofibrillated bacterial cellulose (PTX/NFBC) formulation in a peritoneally disseminated gastric cancer xenograft model.

K. Tajima, T. Ishida, Taro Shimizu, 2021, International journal of biological macromolecules.

Ganglioside inserted into PEGylated liposome attenuates anti‐PEG immunity

T. Ishida, Taro Shimizu, A. S. Abu Lila, 2017, Journal of controlled release : official journal of the Controlled Release Society.

Anti-polyethyleneglycol antibody response to PEGylated substances.

T. Ishida, H. Kiwada, 2013, Biological & pharmaceutical bulletin.

Merit and demerit of complement activation by nanoparticles

T. Ishida, Taro Shimizu, Y. Ishima, 2017 .

Hydrodynamic Tail Vein Injection as a Simple Tool for Yielding Extended Transgene Expression in Solid Tumors.

T. Ishida, Taro Shimizu, Masami Ukawa, 2016, Biological & pharmaceutical bulletin.

A hydroxyl PEG version of PEGylated liposomes and its impact on anti‐PEG IgM induction and on the accelerated clearance of PEGylated liposomes

T. Ishida, Taro Shimizu, A. S. Abu Lila, 2018, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Anti-PEG IgM Response against PEGylated Liposomes in Mice and Rats

T. Ishida, H. Kiwada, Y. Uehara, 2010, Pharmaceutics.

T cell-independent B cell response is responsible for ABC phenomenon induced by repeated injection of PEGylated liposomes.

H. Tsukada, N. Oku, Hiroyuki Koide, 2010, International journal of pharmaceutics.

Efficacy of Intrathecal Liposomal Fasudil for Experimental Cerebral Vasospasm after Subarachnoid Hemorrhage

John H. Zhang, T. Ishida, I. Yamamoto, 2001, Neurosurgery.

Enhancing effect of cholesterol on the elimination of liposomes from circulation is mediated by complement activation

K. Funato, T. Ishida, H. Kiwada, 1997 .

Accelerated Blood Clearance Phenomenon Upon Repeated Injection of PEG-modified PLA-nanoparticles

Tohru Mizushima, Masami Otsuka, Chisa Kobayashi, 2009, Pharmaceutical Research.

Effect of cholesterol content in activation of the classical versus the alternative pathway of rat complement system induced by hydrogenated egg phosphatidylcholine-based liposomes.

H. Harashima, T. Ishida, H. Kiwada, 2001, International journal of pharmaceutics.

Biodistribution of liposomes and C3 fragments associated with liposomes: evaluation of their relationship.

H. Harashima, T. Ishida, H. Kiwada, 2000, International journal of pharmaceutics.

Nucleic acids delivered by PEGylated cationic liposomes in systemic lupus erythematosus-prone mice: a possible exacerbation of lupus nephritis in the presence of pre-existing anti-nucleic acid antibodies.

T. Ishida, Taro Shimizu, Nehal E. Elsadek, 2021, International journal of pharmaceutics.

B cell-intrinsic toll-like receptor 7 is responsible for the enhanced anti-PEG IgM production following injection of siRNA-containing PEGylated lipoplex in mice.

T. Ishida, H. Kiwada, Taro Shimizu, 2014, Journal of controlled release : official journal of the Controlled Release Society.

A novel plasma factor initiating complement activation on cetylmannoside-modified liposomes in human plasma

K. Funato, T. Ishida, H. Kiwada, 1998 .

Liposomal pemetrexed: formulation, characterization and in vitro cytotoxicity studies for effective management of malignant pleural mesothelioma.

T. Ishida, Hanan M Elnahas, M. Mahdy, 2015, Biological & pharmaceutical bulletin.

Electrophoretic behavior of plasmid DNA in the presence of various intercalating dyes.

N. Kaji, M. Tokeshi, Y. Baba, 2006, Journal of chromatography. A.

Hepatosplenic phagocytic cells indirectly contribute to anti-PEG IgM production in the accelerated blood clearance (ABC) phenomenon against PEGylated liposomes: Appearance of an unexplained mechanism in the ABC phenomenon.

T. Ishida, Taro Shimizu, H. Sarhan, 2020, Journal of controlled release : official journal of the Controlled Release Society.

Transport of PEGylated liposomes from the splenic marginal zone to the follicle in the induction phase of the accelerated blood clearance phenomenon.

T. Ishida, H. Kiwada, Taro Shimizu, 2013, Immunobiology.

Effect of the physicochemical properties of initially injected liposomes on the clearance of subsequently injected PEGylated liposomes in mice.

T. Ishida, H. Kiwada, Y. Sadzuka, 2004, Journal of controlled release : official journal of the Controlled Release Society.

PEGylation and anti-PEG antibodies

T. Ishida, Taro Shimizu, A. Lila, 2018 .

Retracted: Effectiveness of cationic liposome‐mediated local delivery of myostatin‐targeting small interfering RNA in vivo

E. Tanaka, T. Ishida, S. Noji, 2014, Development, growth & differentiation.

A novel polyethylene glycol (PEG)‐drug conjugate of Venetoclax, a Bcl‐2 inhibitor, for treatment of acute myeloid leukemia (AML)

T. Ishida, K. Eshima, Yuta Murakami, 2021, Cancer reports.

A Unique Gene-Silencing Approach, Using an Intelligent RNA Expression Device (iRed), Results in Minimal Immune Stimulation When Given by Local Intrapleural Injection in Malignant Pleural Mesothelioma

N. Minakawa, T. Ishida, Taro Shimizu, 2020, Molecules.

Ionic Liquid-Based Transcutaneous Peptide Antitumor Vaccine: Therapeutic Effect in a Mouse Tumor Model

T. Ishida, Taro Shimizu, T. Nakae, 2023, The AAPS Journal.

Species difference in correlation between in vivo/in vitro liposome-complement interactions.

H. Harashima, T. Ishida, H. Kiwada, 2001, Biological & pharmaceutical bulletin.

Characterization of bovine serum factor triggering the lysis of liposomes via complement activation.

T. Ishida, H. Kiwada, S. Liu, 1998, Biological & pharmaceutical bulletin.

A polyethylene glycol-conjugate of deoxycytidine analog, DFP-14927, produces potential antitumor effects on pancreatic tumor-xenograft murine models via inducing G2/M arrest.

T. Ishida, K. Eshima, Hidenori Ando, 2023, European journal of pharmacology.

A Cell Assay for Detecting Anti-PEG Immune Response against PEG-Modified Therapeutics

T. Ishida, Taro Shimizu, A. S. Abu Lila, 2018, Pharmaceutical Research.

Generation, characterization and in vivo biological activity of two distinct monoclonal anti-PEG IgMs.

T. Ishida, H. Kiwada, Taro Shimizu, 2014, Toxicology and applied pharmacology.

Clinical Impact of Antipolyethylene Glycol (PEG) Antibody in Hematological Patients Administered PEGylated‐Granulocyte Colony‐Stimulating Factor

Naoto Okada, T. Ishida, M. Abe, 2023, Clinical pharmacology in drug development.

A novel intraperitoneal therapy for gastric cancer with DFP‐10825, a unique RNAi therapeutic targeting thymidylate synthase, in a peritoneally disseminated xenograft model

M. Fukushima, H. Wada, T. Ishida, 2019, Cancer medicine.

Anti-PEG IgM production induced by PEGylated liposomes as a function of administration route.

T. Ishida, Taro Shimizu, Nehal E. Elsadek, 2023, Journal of controlled release : official journal of the Controlled Release Society.

Apoptosis induction of poly-S-nitrosated human serum albumin in resistant solid tumor under hypoxia can be restored by phosphodiesterase 5 inhibition.

T. Ishida, M. Otagiri, T. Ikeda, 2017, Nitric oxide : biology and chemistry.

Synergistic Effect Between Size and Cholesterol Content in the Enhanced Hepatic Uptake Clearance of Liposomes Through Complement Activation in Rats

H. Harashima, T. Ishida, H. Kiwada, 1996, Pharmaceutical Research.

Development of Kupffer cell targeting type-I interferon for the treatment of hepatitis via inducing anti-inflammatory and immunomodulatory actions

Tomoaki Koga, T. Ishida, M. Otagiri, 2018, Drug delivery.

Effect of siRNA in PEG-coated siRNA-lipoplex on anti-PEG IgM production.

T. Ishida, H. Kiwada, T. Tagami, 2009, Journal of controlled release : official journal of the Controlled Release Society.

Development of an Antigen Delivery System for a B Cell-Targeted Vaccine as an Alternative to Dendritic Cell-Targeted Vaccines.

T. Ishida, Taro Shimizu, Yoshino Kawaguchi, 2022, Chemical & pharmaceutical bulletin.

Anti-PEG Immunity Against PEGylated Therapeutics

T. Ishida, A. Lila, 2019, Immune Aspects of Biopharmaceuticals and Nanomedicines.

Comprehensive analysis of PEGylated liposome‐associated proteins relating to the accelerated blood clearance phenomenon by combination with shotgun analysis and conventional methods

T. Ishida, H. Kiwada, Taro Shimizu, 2015, Biotechnology and applied biochemistry.