H. Kiwada

发表

Complexation of siRNA and pDNA with cationic liposomes: the important aspects in lipoplex preparation.

J. Barichello, T. Ishida, H. Kiwada, 2010, Methods in molecular biology.

An assessment of relative transcriptional availability from nonviral vectors.

Yasuo Shinohara, Hideyoshi Harashima, C Anthony Hunt, 2004, International journal of pharmaceutics.

Intracellular control of gene trafficking using liposomes as drug carriers.

Y. Shinohara, H. Harashima, H. Kiwada, 2001, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Anti-PEG IgM production by siRNA encapsulated in a PEGylated lipid nanocarrier is dependent on the sequence of the siRNA.

T. Ishida, H. Kiwada, T. Tagami, 2011, Journal of controlled release : official journal of the Controlled Release Society.

CpG motifs in pDNA-sequences increase anti-PEG IgM production induced by PEG-coated pDNA-lipoplexes.

N. Yamazaki, T. Ishida, H. Kiwada, 2010, Journal of controlled release : official journal of the Controlled Release Society.

Cell type-specific gene expression, mediated by TFL-3, a cationic liposomal vector, is controlled by a post-transcription process of delivered plasmid DNA.

Xinyu Wang, T. Ishida, H. Kiwada, 2004, International journal of pharmaceutics.

Lipoplex size determines lipofection efficiency with or without serum

Y. Shinohara, H. Harashima, H. Kiwada, 2003, Molecular membrane biology.

Cationic liposome-mediated gene delivery: biophysical study and mechanism of internalization.

Y. Baba, Y. Shinohara, H. Harashima, 2003, Archives of biochemistry and biophysics.

Intracellular regulation of macromolecules using pH-sensitive liposomes and nuclear localization signal: qualitative and quantitative evaluation of intracellular trafficking.

H Harashima, S. Futaki, H. Harashima, 1998, Biochemical and biophysical research communications.

Interactions of liposomes with cells in vitro and in vivo: opsonins and receptors.

H. Harashima, T. Ishida, H. Kiwada, 2001, Current drug metabolism.

Liposome Clearance

H. Harashima, T. Ishida, H. Kiwada, 2002, Bioscience reports.

Quantitative studies on the nuclear transport of plasmid DNA and gene expression employing nonviral vectors.

Y. Shinohara, H. Harashima, H. Kiwada, 2001, Advanced drug delivery reviews.

Tumor targeting of doxorubicin by anti-MT1-MMP antibody-modified PEG liposomes.

H. Harashima, H. Akita, H. Hatakeyama, 2007, International journal of pharmaceutics.

Development of a pharmacokinetic/pharmacodynamic (PK/PD)-simulation system for doxorubicin in long circulating liposomes in mice using peritoneal P388.

H. Harashima, H. Kiwada, M. Tsuchihashi, 1999, Journal of controlled release : official journal of the Controlled Release Society.

Optimization of antitumor effect of liposomally encapsulated doxorubicin based on simulations by pharmacokinetic/pharmacodynamic modeling.

H. Harashima, H. Kiwada, M. Tsuchihashi, 1999, Journal of controlled release : official journal of the Controlled Release Society.

Agitation during lipoplex formation improves the gene knockdown effect of siRNA.

N. Oku, T. Asai, J. Barichello, 2011, International journal of pharmaceutics.

Agitation during lipoplex formation harmonizes the interaction of siRNA to cationic liposomes.

L. Soares, J. Barichello, T. Ishida, 2012, International journal of pharmaceutics.

Sequential administration with oxaliplatin-containing PEG-coated cationic liposomes promotes a significant delivery of subsequent dose into murine solid tumor.

T. Ishida, H. Kiwada, Kazuya Nakamura, 2010, Journal of controlled release : official journal of the Controlled Release Society.

Particle size-dependent triggering of accelerated blood clearance phenomenon.

M. Yokoyama, N. Oku, Hiroyuki Koide, 2008, International journal of pharmaceutics.

Contribution of complement system on destabilization of liposomes composed of hydrogenated egg phosphatidylcholine in rat fresh plasma.

K. Funato, H. Kiwada, R. Yoda, 1992, Biochimica et biophysica acta.

Accelerated blood clearance (ABC) phenomenon upon repeated injection of PEGylated liposomes.

T. Ishida, H. Kiwada, 2008, International journal of pharmaceutics.

Unexpected Reactions by In Vivo Applications of PEGylated Liposomes

T. Ishida, H. Kiwada, 2009 .

Complement dependent and independent liposome uptake by peritoneal macrophages: cholesterol content dependency.

H. Harashima, H. Kiwada, T. M. Huong, 1998, Biological & pharmaceutical bulletin.

Development of pH-sensitive liposomes that efficiently retain encapsulated doxorubicin (DXR) in blood.

T. Ishida, H. Kiwada, Y. Okada, 2006, International journal of pharmaceutics.

Effect of cationic liposomes in an in vitro transcription and translation system.

Y. Baba, Y. Shinohara, H. Harashima, 2002, Biological & pharmaceutical bulletin.

Alteration of tumor microenvironment for improved delivery and intratumor distribution of nanocarriers.

T. Ishida, H. Kiwada, 2013, Biological & pharmaceutical bulletin.

Application of polyglycerol coating to plasmid DNA lipoplex for the evasion of the accelerated blood clearance phenomenon in nucleic acid delivery.

T. Ishida, H. Kiwada, Y. Uehara, 2014, Journal of pharmaceutical sciences.

The accelerated blood clearance (ABC) phenomenon: clinical challenge and approaches to manage.

T. Ishida, H. Kiwada, A. S. Abu Lila, 2013, Journal of controlled release : official journal of the Controlled Release Society.

Use of polyglycerol (PG), instead of polyethylene glycol (PEG), prevents induction of the accelerated blood clearance phenomenon against long-circulating liposomes upon repeated administration.

T. Ishida, H. Kiwada, Taro Shimizu, 2013, International journal of pharmaceutics.

Influence of the physicochemical properties of liposomes on the accelerated blood clearance phenomenon in rats.

T. Ishida, H. Kiwada, Xinyu Wang, 2005, Journal of controlled release : official journal of the Controlled Release Society.

Design, preparation and directional insertion of peptides into lipid bilayer membrane and their application for the preparation of liposome of which surface could be coated by externally added antibody

T. Matsuo, N. Yamazaki, Y. Shinohara, 2007, 2007 International Symposium on Micro-NanoMechatronics and Human Science.

Mutant coat proteins of Pf3 bacteriophage as models of membrane proteins and their interactions with lipid bilayer membrane

T. Matsuo, N. Yamazaki, Y. Shinohara, 2006, 2006 IEEE International Symposium on MicroNanoMechanical and Human Science.

Plasma Factor Triggering Alternative Complement Pathway Activation by Liposomes

K. Funato, H. Kiwada, C. Yamashita, 2004, Pharmaceutical Research.

Comparative analysis of in vitro and in vivo pharmacokinetic parameters related to individual variability of GTS-21 in canine.

H. Kiwada, M. Hayashi, Y. Kawaguchi, 2002, Drug metabolism and pharmacokinetics.

First-pass of GTS-21 on canine gut wall and liver determined by portal-systemic concentration difference.

H. Kiwada, H. Manabe, M. Komuro, 2001, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Feasibility of magnetic liposomes as a targeting device for drugs.

S. Yamada, H. Kiwada, Y. Kato, 1986, Chemical & pharmaceutical bulletin.

The contribution of phagocytic activity of liver macrophages to the accelerated blood clearance (ABC) phenomenon of PEGylated liposomes in rats.

T. Ishida, H. Kiwada, Syuntaro Kashima, 2008, Journal of controlled release : official journal of the Controlled Release Society.

Spleen plays an important role in the induction of accelerated blood clearance of PEGylated liposomes.

T. Ishida, H. Kiwada, Xinyu Wang, 2006, Journal of controlled release : official journal of the Controlled Release Society.

The accelerated clearance on repeated injection of pegylated liposomes in rats: laboratory and histopathological study.

T. Ishida, H. Kiwada, M. Ichihara, 2002, Cellular & molecular biology letters.

Inducing effect of liposomalization on the transdermal delivery of hydrocortisone: creation of a drug supersaturated state.

T. Ishida, H. Kiwada, H. Handa, 2006, Journal of controlled release : official journal of the Controlled Release Society.

Oxaliplatin encapsulated in PEG-coated cationic liposomes induces significant tumor growth suppression via a dual-targeting approach in a murine solid tumor model.

T. Ishida, H. Kiwada, S. Kizuki, 2009, Journal of controlled release : official journal of the Controlled Release Society.

Abrogation of the accelerated blood clearance phenomenon by SOXL regimen: promise for clinical application.

T. Ishida, H. Kiwada, A. S. Abu Lila, 2013, International journal of pharmaceutics.

Combination therapy of metronomic S‐1 dosing with oxaliplatin‐containing polyethylene glycol‐coated liposome improves antitumor activity in a murine colorectal tumor model

T. Ishida, H. Kiwada, Yusuke Doi, 2010, Cancer science.

Improved intratumoral delivery of PEG-coated siRNA-lipoplexes by combination with metronomic S-1 dosing in a murine solid tumor model

M. Matsunaga, T. Ishida, H. Kiwada, 2012, Drug Delivery and Translational Research.

Tumor-type-dependent vascular permeability constitutes a potential impediment to the therapeutic efficacy of liposomal oxaliplatin.

T. Ishida, H. Kiwada, A. S. Abu Lila, 2012, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Multiple administration of PEG-coated liposomal oxaliplatin enhances its therapeutic efficacy: a possible mechanism and the potential for clinical application.

T. Ishida, H. Kiwada, Noha Essam Eldin, 2012, International journal of pharmaceutics.

Kinetic modelling of liposome degradation in peritoneal macrophages

H. Harashima, H. Kiwada, N. Hirai, 1995, Biopharmaceutics & drug disposition.

Increased gene expression by cationic liposomes (TFL-3) in lung metastases following intravenous injection.

N. Oku, T. Ishida, H. Kiwada, 2005, Biological & pharmaceutical bulletin.

Habitat differentiation between sei (Balaenoptera borealis) and Bryde's whales (B. brydei) in the western North Pacific

S. Saitoh, H. Murase, H. Kiwada, 2013 .

Liposomal targeting and drug delivery: kinetic consideration

H. Harashima, H. Kiwada, 1996 .

Effect of serum on dose- and temperature-dependent hepatic uptake of multilamellar vesicles (MLV).

H. Kiwada, M. Hayashi, S. Awazu, 1989, Journal of pharmacobio-dynamics.

The study on the biological fate of paraben at the dose of practical usage in rat. II. The pharmacokinetic study on the blood concentration after the administration of ethyl paraben or p-hydroxybenzoic acid.

H. Kiwada, S. Awazu, M. Hanano, 1980, Journal of pharmacobio-dynamics.

THE STUDY ON THE BIOLOGICAL FATE OF PARABEN AT THE DOSE OF PRACTICAL USAGE IN RAT. I. THE METABOLISM AND EXCRETION OF ETHYL p-HYDROXYBENZOATE (ETHYLPARABEN) AND p-HYDROXYBENZOIC ACID

H. Kiwada, S. Awazu, M. Hanano, 1979 .

Enhanced Hepatic Uptake of Liposomes Through Complement Activation Depending on the Size of Liposomes

Hideyoshi Harashima, K. Funato, H. Harashima, 1994, Pharmaceutical Research.

Species Difference in the Disposition of Liposomes Among Mice, Rats, and Rabbits: Allometric Relationship and Species Dependent Hepatic Uptake Mechanism

H. Harashima, H. Kiwada, S. Kojima, 1996, Pharmaceutical Research.

In vivo evaluation of the effect of the size and opsonization on the hepatic extraction of liposomes in rats: An application of Oldendorf method

H. Harashima, H. Kiwada, Y. Ohnishi, 1992, Biopharmaceutics & drug disposition.

Distinction Between the Depletion of Opsonins and the Saturation of Uptake in the Dose-Dependent Hepatic Uptake of Liposomes

H. Harashima, H. Kiwada, K. Sakata, 1993, Pharmaceutical Research.

The complement- but not mannose receptor-mediated phagocytosis is involved in the hepatic uptake of cetylmannoside-modified liposomes in situ.

K. Funato, H. Harashima, H. Kiwada, 1994, Journal of drug targeting.

Repopulation of murine Kupffer cells after intravenous administration of liposome-encapsulated dichloromethylene diphosphonate.

H. Kiwada, M. Arakawa, H. Umezu, 1996, American Journal of Pathology.

Application of synthetic alkyl glycoside vesicles as drug carriers. I. Preparation and physical properties.

S. Yamada, H. Kiwada, Y. Kato, 1985, Chemical & pharmaceutical bulletin.

Immunoliposomal drug-delivery system targeting lectin-like oxidized low-density lipoprotein receptor-1 for carotid plaque lesions in rats.

T. Tominaga, M. Fujimura, T. Ishida, 2011, Journal of neurosurgery.

The complement system enhances the clearance of phosphatidylserine (PS)-liposomes in rat and guinea pig.

H. Harashima, T. Ishida, H. Kiwada, 2001, International journal of pharmaceutics.

Anti-PEG IgM and complement system are required for the association of second doses of PEGylated liposomes with splenic marginal zone B cells.

T. Ishida, H. Kiwada, Taro Shimizu, 2015, Immunobiology.

Correlations between in Vivo and in Vitro Dissolution Rates of (α-Bromoisovaleryl) urea Polymorphs

H. Kiwada, H. Kojima, Y. Kato, 1984 .

The Co-Delivery of Oxaliplatin Abrogates the Immunogenic Response to PEGylated siRNA-Lipoplex

T. Ishida, H. Kiwada, Naoto Moriyoshi, 2013, Pharmaceutical Research.

Effects of the size and fluidity of liposomes on their accumulation in tumors: A presumption of their interaction with tumors

H. Harashima, H. Kiwada, K. Uchiyama, 1995 .

Ex-vivo/in-vitro anti-polyethylene glycol (PEG) immunoglobulin M production from murine splenic B cells stimulated by PEGylated liposome.

T. Ishida, H. Kiwada, Taro Shimizu, 2013, Biological & pharmaceutical bulletin.

Anti-PEG IgM production via a PEGylated nano-carrier system for nucleic acid delivery.

T. Ishida, H. Kiwada, Naoto Moriyoshi, 2013, Methods in molecular biology.

Activation of TLR9 by incorporated pDNA within PEG-coated lipoplex enhances anti-PEG IgM production

T. Ishida, H. Kiwada, Y. Uehara, 2014, Gene Therapy.

The Dissolution Properties and Physico-chemical Properties of Polymorphic Forms of (α-Bromoisovaleryl) urea

H. Kiwada, H. Kojima, Y. Kato, 1982 .

Kinetic modelling of liposome degradation in serum: Effect of size and concentration of liposomes in vitro

H. Harashima, H. Kiwada, Y. Ochi, 1994, Biopharmaceutics & drug disposition.

Kinetic modeling of liposome degradation in blood circulation

H. Harashima, H. Kiwada, Y. Kume, 1993, Biopharmaceutics & drug disposition.

Evasion of the accelerated blood clearance phenomenon by coating of nanoparticles with various hydrophilic polymers.

T. Ishida, H. Kiwada, T. Maeda, 2010, Biomacromolecules.

Lactoferrin inhibits platelet production from human megakaryocytes in vitro.

T. Ishida, H. Kiwada, T. Taki, 2008, Biological & pharmaceutical bulletin.

Safe and efficient drug delivery system with liposomes for intrathecal application of an antivasospastic drug, fasudil.

T. Ishida, H. Kiwada, Y. Takanashi, 2006, Biological & pharmaceutical bulletin.

Kinetic analysis of tissue distribution of doxorubicin incorporated in liposomes in rats (II)

H. Harashima, H. Kiwada, H. Kikuchi, 1992, Biopharmaceutics & drug disposition.

Effects of benidipine hydrochloride (Coniel®), a new calcium antagonist, on the cardiac output, regional blood flow and vascular resistance in conscious, spontaneously hypertensive rats

H. Harashima, H. Kiwada, S. Kobayashi, 1994, Biopharmaceutics & drug disposition.

Mechanism of initial distribution of blood-borne colon carcinoma cells in the liver.

Y. Sugiyama, T. Irimura, H. Harashima, 1998, Journal of hepatology.

Is control of distribution of liposomes between tumors and bone marrow possible?

Y. Kawai, H. Kiwada, K. Uchiyama, 1996, Biochimica et biophysica acta.

Effect of cetylmannoside modification on the alternative complement pathway activation by liposomes in rat serum.

H. Kiwada, H. Matsuo, C. Yamashita, 1995, Biological & pharmaceutical bulletin.

Effect of Co-administration of Tacrolimus on the Pharmacokinetics of Multiple Subcutaneous Administered Interferon-Alpha in Rats

M. Odomi, T. Ishida, H. Kiwada, 2009, Pharmaceutical Research.

Accelerated blood clearance of PEGylated liposomes containing doxorubicin upon repeated administration to dogs.

T. Ishida, H. Kiwada, H. Kikuchi, 2012, International journal of pharmaceutics.

Kinetic study on the optimization of tumor delivery of antitumor agents by liposomes: Simulation study based on the physiological modeling.

H. Harashima, H. Kiwada, S. Iida, 1997 .

Effect of vesicle size on in vivo release of daunorubicin from hydrogenated egg phosphatidylcholine-based liposomes into blood circulation.

H. Kiwada, T. Shimooka, A. Nagayasu, 1995, Biological & pharmaceutical bulletin.

Size dependent liposome degradation in blood: in vivo/in vitro correlation by kinetic modeling.

H. Harashima, H. Kiwada, T. Hiraiwa, 1995, Journal of drug targeting.

Effects of fluidity and vesicle size on antitumor activity and myelosuppressive activity of liposomes loaded with daunorubicin.

H. Kiwada, Y. Takeichi, T. Shimooka, 1994, Biological & pharmaceutical bulletin.

pH-sensitive liposomes in nuclear targeting of macromolecules.

S. Futaki, H. Harashima, H. Kiwada, 2003, Methods in enzymology.

Effects of dose and vesicle size on the pharmacokinetics of liposomes.

H. Kiwada, Y. Kato, Y. Sato, 1986, Chemical & pharmaceutical bulletin.

[Accelerated blood clearance (ABC) phenomenon induced by administration of PEGylated liposome].

T. Ishida, H. Kiwada, 2008, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Co-administration of tacrolimus suppresses pharmacokinetic modulation of multiple subcutaneously administered human interferon-alpha in Beagle dogs.

M. Odomi, T. Ishida, H. Kiwada, 2010, Drug metabolism and pharmacokinetics.

Kinetic analysis of AUC-dependent saturable clearance of liposomes: Mathematical description of AUC dependency

H. Harashima, H. Kiwada, Y. Kume, 1993, Journal of Pharmacokinetics and Biopharmaceutics.

Effect of transferrin receptor-targeted liposomal doxorubicin in P-glycoprotein-mediated drug resistant tumor cells.

Hideyoshi Harashima, H. Harashima, T. Ishida, 2007, International journal of pharmaceutics.

Anti-PEG IgM Is a Major Contributor to the Accelerated Blood Clearance of Polyethylene Glycol-Conjugated Protein.

T. Ishida, H. Kiwada, Taro Shimizu, 2015, Molecular pharmaceutics.

PEGylated liposomes elicit an anti-PEG IgM response in a T cell-independent manner.

Taro Shimizu, Xinyu Wang, T. Ishida, 2007, Journal of controlled release : official journal of the Controlled Release Society.

Combined effect of liposomalization and addition of glycerol on the transdermal delivery of isosorbide 5-nitrate in rat skin.

T. Ishida, H. Kiwada, H. Handa, 2008, International journal of pharmaceutics.

Anti-angiogenic therapy via cationic liposome-mediated systemic siRNA delivery.

M. Matsunaga, T. Ishida, H. Kiwada, 2012, International journal of pharmaceutics.

Argonaute2 is a potential target for siRNA-based cancer therapy for HT1080 human fibrosarcoma

N. Yamazaki, N. Oku, T. Asai, 2011, Drug Delivery and Translational Research.

Global Gene Expression Profiling in Cultured Cells Is Strongly Influenced by Treatment with siRNA–Cationic Liposome Complexes

T. Ishida, H. Kiwada, T. Tagami, 2008, Pharmaceutical Research.

Disappearance of the angiogenic potential of endothelial cells caused by Argonaute2 knockdown.

Tomohiro Asai, Naoto Oku, J. Yokota, 2008, Biochemical and biophysical research communications.

Anti-PEG IgM elicited by injection of liposomes is involved in the enhanced blood clearance of a subsequent dose of PEGylated liposomes.

T. Ishida, H. Kiwada, Xinyu Wang, 2007, Journal of controlled release : official journal of the Controlled Release Society.

A double-modulation strategy in cancer treatment with a chemotherapeutic agent and siRNA.

M. Matsunaga, T. Ishida, H. Kiwada, 2011, Molecular therapy : the journal of the American Society of Gene Therapy.

The gene-silencing effect of siRNA in cationic lipoplexes is enhanced by incorporating pDNA in the complex.

T. Ishida, H. Kiwada, H. Kikuchi, 2007, International journal of pharmaceutics.

Pharmacokinetic analysis of the cardioprotective effect of 3-(2,2, 2-trimethylhydrazinium) propionate in mice: inhibition of carnitine transport in kidney.

Y. Sugiyama, H. Harashima, H. Kiwada, 1999, The Journal of pharmacology and experimental therapeutics.

Prey preferences of common minke (Balaenoptera acutorostrata), Bryde’s (B. edeni) and sei (B. borealis) whales in offshore component of JARPNII from 2002 to 2007

H. Okamura, T. Tamura, H. Murase, 2016 .

Habitat and prey selection of common minke, sei, and Bryde’s whales in mesoscale during summer in the subarctic and transition regions of the western North Pacific

T. Tamura, H. Kiwada, M. Okazaki, 2012, Fisheries Science.

Gene expression analysis during platelet-like particle production in phorbol myristate acetate-treated MEG-01 cells.

T. Ono, Takuma Kawakami, T. Ishida, 2009, Biological & pharmaceutical bulletin.

Accelerated clearance of a second injection of PEGylated liposomes in mice.

T. Ishida, H. Kiwada, Tatsuhiro Ishida, 2003, International journal of pharmaceutics.

Accelerated clearance of PEGylated liposomes in rats after repeated injections.

T. Ishida, H. Kiwada, Tatsuhiro Ishida, 2003, Journal of controlled release : official journal of the Controlled Release Society.

Synthesis and evaluation of a prototypal artificial red cell.

C. Hunt, H. Kiwada, R. Burnette, 1985, Science.

Influence of dose and animal species on accelerated blood clearance of PEGylated liposomal doxorubicin.

T. Ishida, H. Kiwada, H. Kikuchi, 2014, International journal of pharmaceutics.

Selective delivery of oxaliplatin to tumor tissue by nanocarrier system enhances overall therapeutic efficacy of the encapsulated oxaliplatin.

T. Ishida, H. Kiwada, A. Lila, 2014, Biological & pharmaceutical bulletin.

Oxaliplatin targeting to angiogenic vessels by PEGylated cationic liposomes suppresses the angiogenesis in a dorsal air sac mouse model.

T. Ishida, H. Kiwada, Yusuke Doi, 2009, Journal of controlled release : official journal of the Controlled Release Society.

Recent advances in tumor vasculature targeting using liposomal drug delivery systems

T. Ishida, H. Kiwada, A. S. Abu Lila, 2009, Expert opinion on drug delivery.

Suppression of immune response by antigen-modified liposomes encapsulating model agents: a novel strategy for the treatment of allergy.

N. Oku, T. Asai, T. Ishida, 2013, Journal of controlled release : official journal of the Controlled Release Society.

In vitro efficacy of a sterically stabilized immunoliposomes targeted to membrane type 1 matrix metalloproteinase (MT1-MMP).

Hideo Kobayashi, Takanori Aoki, Hiroshi Kikuchi, 2007, Biological & pharmaceutical bulletin.

Sequential treatment of oxaliplatin-containing PEGylated liposome together with S-1 improves intratumor distribution of subsequent doses of oxaliplatin-containing PEGylated liposome.

T. Ishida, H. Kiwada, A. S. Abu Lila, 2014, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Synergistic antitumor activity of metronomic dosing of cyclophosphamide in combination with doxorubicin-containing PEGylated liposomes in a murine solid tumor model.

T. Ishida, H. Kiwada, Emi Shiraga, 2009, Journal of controlled release : official journal of the Controlled Release Society.

Targeting Anticancer Drugs to Tumor Vasculature Using Cationic Liposomes

T. Ishida, H. Kiwada, A. S. Abu Lila, 2010, Pharmaceutical Research.

Quantitative Analysis of Correlation Between Number of Nuclear Plasmids and Gene Expression Activity After Transfection with Cationic Liposomes

Yasuo Shinohara, Hiroshi Kikuchi, Hideyoshi Harashima, 2002, Pharmaceutical Research.

HEPC-based liposomes trigger cytokine release from peripheral blood cells: effects of liposomal size, dose and lipid composition.

M. Muraguchi, T. Ishida, H. Kiwada, 2002, International journal of pharmaceutics.

The study on the biological fate of paraben at the dose of practical usage in rat. III. The effects of salicylic acid on the fate of ethyl paraben.

H. Kiwada, S. Awazu, M. Hanano, 1981, Journal of pharmacobio-dynamics.

Stimulatory effect of polyethylene glycol (PEG) on gene expression in mouse liver following hydrodynamics‐based transfection

T. Ishida, H. Kiwada, Wenhao Li, 2006, The journal of gene medicine.

Potential Value of Cetylmannoside‐modified Liposomes as Carriers of Macrophage Activators to Human Blood Monocytes

S. Sone, H. Kiwada, T. Ogura, 1991, Japanese journal of cancer research : Gann.

A metronomic schedule of cyclophosphamide combined with PEGylated liposomal doxorubicin has a highly antitumor effect in an experimental pulmonary metastatic mouse model.

T. Ishida, H. Kiwada, J. M. Barichello, 2008, International journal of pharmaceutics.

Complex formation with plasmid DNA increases the cytotoxicity of cationic liposomes.

T. Ishida, H. Kiwada, J. M. Barichello, 2007, Biological & pharmaceutical bulletin.

Encapsulation of an antivasospastic drug, fasudil, into liposomes, and in vitro stability of the fasudil-loaded liposomes.

T. Ishida, H. Kiwada, I. Yamamoto, 2002, International journal of pharmaceutics.

Efficient gene expression in megakaryocytic cell line using nucleofection.

T. Ishida, H. Kiwada, T. Taki, 2007, International journal of pharmaceutics.

Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes.

T. Ishida, H. Kiwada, Xinyu Wang, 2006, Journal of controlled release : official journal of the Controlled Release Society.

[Effects of ascorbic acid on the free radical formations of isoniazid and its metabolites].

H. Kiwada, K. Tsuchiya, T. Goromaru, 1991, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Accelerated blood clearance of PEGylated liposomes upon repeated injections: effect of doxorubicin-encapsulation and high-dose first injection.

T. Ishida, H. Kiwada, Tatsuhiro Ishida, 2006, Journal of controlled release : official journal of the Controlled Release Society.

Relationship between the concentration of anti-polyethylene glycol (PEG) immunoglobulin M (IgM) and the intensity of the accelerated blood clearance (ABC) phenomenon against PEGylated liposomes in mice.

T. Ishida, H. Kiwada, Taro Shimizu, 2015, Biological & pharmaceutical bulletin.

Accelerated blood clearance of PEGylated liposomes following preceding liposome injection: effects of lipid dose and PEG surface-density and chain length of the first-dose liposomes.

Xin Yu Wang, T. Ishida, H. Kiwada, 2005, Journal of controlled release : official journal of the Controlled Release Society.

Optimized PEGylated adenovirus vector reduces the anti-vector humoral immune response against adenovirus and induces a therapeutic effect against metastatic lung cancer.

Y. Yoshioka, S. Nakagawa, H. Mizuguchi, 2010, Biological & pharmaceutical bulletin.

Intravenous administration of polyethylene glycol-coated (PEGylated) proteins and PEGylated adenovirus elicits an anti-PEG immunoglobulin M response.

Y. Yoshioka, S. Nakagawa, T. Ishida, 2012, Biological & pharmaceutical bulletin.

Anti-polyethyleneglycol antibody response to PEGylated substances.

T. Ishida, H. Kiwada, 2013, Biological & pharmaceutical bulletin.

Prey selection of common minke (Balaenoptera acutorostrata) and Bryde's (Balaenoptera edeni) whales in the western North Pacific in 2000 and 2001

Hiroshi Okamura, Tsutomu Tamura, Hiroto Murase, 2007 .

Decrease in stomach contents in the Antarctic minke whale (Balaenoptera bonaerensis) in the Southern Ocean

L. Walløe, H. Kiwada, T. Kitakado, 2014, Polar Biology.

Isotopic fractionation of aminopyrine from its deuterated analogues and application for evaluation of hepatic function by capillary gas chromatography

H. Kiwada, T. Goromaru, H. Maeda, 1993 .

Anti-PEG IgM Response against PEGylated Liposomes in Mice and Rats

T. Ishida, H. Kiwada, Y. Uehara, 2010, Pharmaceutics.

T cell-independent B cell response is responsible for ABC phenomenon induced by repeated injection of PEGylated liposomes.

H. Tsukada, N. Oku, Hiroyuki Koide, 2010, International journal of pharmaceutics.

Non‐Michaelis–Menten Type Hepatic Uptake of Liposomes in the Rat

H. Harashima, H. Kiwada, Yoshihiro Kume, 1992, The Journal of pharmacy and pharmacology.

Enhancing effect of cholesterol on the elimination of liposomes from circulation is mediated by complement activation

K. Funato, T. Ishida, H. Kiwada, 1997 .

Saturable, Non‐Michaelis‐Menten Uptake of Liposomes by the Reticuloendothelial System

H. Harashima, H. Kiwada, F. Maeda, 1991, The Journal of pharmacy and pharmacology.

A new numerical calculation method for deconvolution in linear compartment analysis of pharmacokinetics.

H. Kiwada, M. Hayashi, S. Awazu, 1977, Chemical & pharmaceutical bulletin.

Accelerated Blood Clearance Phenomenon Upon Repeated Injection of PEG-modified PLA-nanoparticles

Tohru Mizushima, Masami Otsuka, Chisa Kobayashi, 2009, Pharmaceutical Research.

Effect of cholesterol content in activation of the classical versus the alternative pathway of rat complement system induced by hydrogenated egg phosphatidylcholine-based liposomes.

H. Harashima, T. Ishida, H. Kiwada, 2001, International journal of pharmaceutics.

Biodistribution of liposomes and C3 fragments associated with liposomes: evaluation of their relationship.

H. Harashima, T. Ishida, H. Kiwada, 2000, International journal of pharmaceutics.

B cell-intrinsic toll-like receptor 7 is responsible for the enhanced anti-PEG IgM production following injection of siRNA-containing PEGylated lipoplex in mice.

T. Ishida, H. Kiwada, Taro Shimizu, 2014, Journal of controlled release : official journal of the Controlled Release Society.

A novel plasma factor initiating complement activation on cetylmannoside-modified liposomes in human plasma

K. Funato, T. Ishida, H. Kiwada, 1998 .

Electrophoretic behavior of plasmid DNA in the presence of various intercalating dyes.

N. Kaji, M. Tokeshi, Y. Baba, 2006, Journal of chromatography. A.

Transport of PEGylated liposomes from the splenic marginal zone to the follicle in the induction phase of the accelerated blood clearance phenomenon.

T. Ishida, H. Kiwada, Taro Shimizu, 2013, Immunobiology.

Effect of the physicochemical properties of initially injected liposomes on the clearance of subsequently injected PEGylated liposomes in mice.

T. Ishida, H. Kiwada, Y. Sadzuka, 2004, Journal of controlled release : official journal of the Controlled Release Society.

Possible source of the antarctic bottom water in the Prydz Bay Region

K. Hanawa, T. Suga, H. Kiwada, 2006 .

Studies on the uptake mechanism of liposomes by perfused rat liver. II. An indispensable factor for liver uptake in serum.

H. Kiwada, Y. Kato, T. Miyajima, 1987, Chemical and pharmaceutical bulletin.

Species difference in correlation between in vivo/in vitro liposome-complement interactions.

H. Harashima, T. Ishida, H. Kiwada, 2001, Biological & pharmaceutical bulletin.

Studies on the Mechanism of Uptake of Liposomes Using An Isolated Perfused Liver System

H. Harashima, H. Kiwada, 1996 .

Characterization of bovine serum factor triggering the lysis of liposomes via complement activation.

T. Ishida, H. Kiwada, S. Liu, 1998, Biological & pharmaceutical bulletin.

Generation, characterization and in vivo biological activity of two distinct monoclonal anti-PEG IgMs.

T. Ishida, H. Kiwada, Taro Shimizu, 2014, Toxicology and applied pharmacology.

Tissue distribution and pharmacokinetic evaluation of the targeting efficiency of synthetic alkyl glycoside vesicles.

H. Kiwada, Y. Kato, H. Niimura, 1985, Chemical & pharmaceutical bulletin.

Synergistic Effect Between Size and Cholesterol Content in the Enhanced Hepatic Uptake Clearance of Liposomes Through Complement Activation in Rats

H. Harashima, T. Ishida, H. Kiwada, 1996, Pharmaceutical Research.

In vivo studies on the role of complement in the clearance of liposomes in rats and guinea pigs.

H. Harashima, H. Kiwada, T. M. Huong, 1999, Biological & pharmaceutical bulletin.

Effect of siRNA in PEG-coated siRNA-lipoplex on anti-PEG IgM production.

T. Ishida, H. Kiwada, T. Tagami, 2009, Journal of controlled release : official journal of the Controlled Release Society.

Solubilization by Triton X-100 makes possible complete recovery of lipids from liposomes in enzymatic assay.

H. Kiwada, T. Shimooka, A. Nagayasu, 1994, Biochimica et biophysica acta.

Results of oceanographic analyses conducted under JARPA and possible evidence of environmental changes

K. Hanawa, T. Suga, H. Kiwada, 2006 .

Comprehensive analysis of PEGylated liposome‐associated proteins relating to the accelerated blood clearance phenomenon by combination with shotgun analysis and conventional methods

T. Ishida, H. Kiwada, Taro Shimizu, 2015, Biotechnology and applied biochemistry.

The Co-Delivery of Oxaliplatin Abrogates the Immunogenic Response to PEGylated siRNA-Lipoplex

T. Ishida, H. Kiwada, Naoto Moriyoshi, 2013, Pharmaceutical Research.

Improved intratumoral delivery of PEG-coated siRNA-lipoplexes by combination with metronomic S-1 dosing in a murine solid tumor model

M. Matsunaga, T. Ishida, H. Kiwada, 2012, Drug Delivery and Translational Research.

The size of liposomes: a factor which affects their targeting efficiency to tumors and therapeutic activity of liposomal antitumor drugs.

Uchiyama, H. Kiwada, Kiwada, 1999, Advanced drug delivery reviews.

Identification of proteins mediating clearance of liposomes using a liver perfusion system.

H. Harashima, H. Kiwada, H. Matsuo, 1998, Advanced drug delivery reviews.

Combination therapy with metronomic S-1 dosing and oxaliplatin-containing PEG-coated cationic liposomes in a murine colorectal tumor model: synergy or antagonism?

T. Ishida, H. Kiwada, A. S. Abu Lila, 2012, International journal of pharmaceutics.

Oxaliplatin targeting to angiogenic vessels by PEGylated cationic liposomes suppresses the angiogenesis in a dorsal air sac mouse model.

T. Ishida, H. Kiwada, Yusuke Doi, 2009, Journal of controlled release : official journal of the Controlled Release Society.

Pharmacokinetic/pharmacodynamic modeling of antitumor agents encapsulated into liposomes.

H. Harashima, H. Kiwada, M. Tsuchihashi, 1999, Advanced drug delivery reviews.

Intra-tumor distribution of PEGylated liposome upon repeated injection: No possession by prior dose.

T. Ishida, H. Kiwada, A. S. Abu Lila, 2015, Journal of controlled release : official journal of the Controlled Release Society.

Combination therapy of metronomic S‐1 dosing with oxaliplatin‐containing polyethylene glycol‐coated liposome improves antitumor activity in a murine colorectal tumor model

T. Ishida, H. Kiwada, Yusuke Doi, 2010, Cancer science.

Evasion of the accelerated blood clearance phenomenon by coating of nanoparticles with various hydrophilic polymers.

T. Ishida, H. Kiwada, T. Mizushima, 2010, Biomacromolecules.