J. Liégeois

发表

The sigma agonist 1,3-di-o-tolyl-guanidine directly blocks SK channels in dopaminergic neurons and in cell lines.

J. Scuvée-Moreau, Cédric Lamy, S. Dilly, 2010, European journal of pharmacology.

Deciphering the molecular mechanism of SK2 channel activation by intracellular calcium to develop new therapeutic agents

J. Liégeois, F. Kerff, R. Vitello, 2020, Acta physiologica.

Bis‐(1,2,3,4‐tetrahydroisoquinolinium): A Chiral Scaffold for Developing High‐Affinity Ligands for SK Channels

J. Wouters, S. Dilly, J. Liégeois, 2014, ChemMedChem.

Synthesis and radioligand binding studies of bis-(8-isopropyl-isoquinolinium) derivatives as ligands for apamin-sensitive sites on cloned SK2 and SK3 channels.

S. Dilly, J. Liégeois, V. Seutin, 2011, Bioorganic & medicinal chemistry letters.

Bis-tetrahydroisoquinoline derivatives: structure analysis of the three stereoisomers of 1,1'-(propane-1,3-diyl)-bis-(6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline).

B. Norberg, J. Wouters, J. Liégeois, 2010, European journal of medicinal chemistry.

Cyproterone and a comparison with its acetate ester

J. Wouters, J. Liégeois, J. Ruyck, 2005 .

Enhancing a CH-π Interaction to Increase the Affinity for 5-HT1A Receptors.

J. Scuvée-Moreau, S. Dilly, J. Liégeois, 2014, ACS medicinal chemistry letters.

Synthesis and pharmacology of pyrid-3-ylsulfonylcyanoguanidines as diuretics

P. Tullio, B. Masereel, J. Liégeois, 1995 .

Analogues of torasemide — structure function relationships —experiments in the thick ascending limb of the loop of Henle of rabbit nephron

P. Wangemann, J. Liégeois, R. Greger, 2004, Pflügers Archiv.

Potentiation of the pro-inflammatory effects of bradykinin by inhibition of angiotensin-converting enzyme and aminopeptidase P in rat paws

W. Simmons, J. Liégeois, J. Damas, 1996, Naunyn-Schmiedeberg's Archives of Pharmacology.

The inflammatory reaction induced by formalin in the rat paw

J. Liégeois, J. Damas, 1999, Naunyn-Schmiedeberg's Archives of Pharmacology.

Involvement of 5-hydroxytryptamine and bradykinin in the hyperalgesia induced in rats by collagenase from clostridium histolyticum

J. Liégeois, J. Damas, V. Bourdon, 1997, Naunyn-Schmiedeberg's Archives of Pharmacology.

Oxidation sensitivity may be a useful tool for the detection of the hematotoxic potential of newly developed molecules: application to antipsychotic drugs.

H. Meltzer, J. Liégeois, J. Kauffmann, 1999, Archives of biochemistry and biophysics.

New Alkoxypyridine-sulfonamides: Synthesis, Biological Evaluation, and Physicochemical Properties

G. Dive, J. Liégeois, L. Dupont, 1991 .

Synthesis and biological evaluation of N-methyl-laudanosine iodide analogues as potential SK channel blockers.

J. Scuvée-Moreau, J. Liégeois, V. Seutin, 2005, Bioorganic & medicinal chemistry.

The behavioral effects of acute and chronic JL 13, a putative antipsychotic, in Cebus non-human primates

J. Liégeois, D. Casey, J. Bruhwyler, 2001, Psychopharmacology.

Dopamine D4 selective ligands as potential antipsychotics

J. Liégeois, J. Bruhwyler, 1997 .

Influence of several peptidase inhibitors on the pro-inflammatory effects of substance P, capsaicin and collagenase

W. Simmons, J. Liégeois, J. Damas, 1996, Naunyn-Schmiedeberg's Archives of Pharmacology.

New pyridobenzoxazepine derivatives derived from 5-(4-methylpiperazin-1-yl)-8-chloro-pyrido[2,3-b][1,5]benzoxazepine (JL13): chemical synthesis and pharmacological evaluation.

F. Tarazi, Cédric Lamy, S. Dilly, 2012, Journal of medicinal chemistry.

Effects of JL13, a pyridobenzoxazepine compound, in dopaminergic and glutamatergic models of antipsychotic activity.

J. Liégeois, A. C. Issy, E. D. Del Bel, 2020, Behavioural pharmacology.

Implementation of a design space approach for enantiomeric separations in polar organic solvent chromatography.

P. Hubert, E. Rozet, J. Liégeois, 2013, Journal of pharmaceutical and biomedical analysis.

Minimal effects of JL 13, a pyridobenzoxazepine derivative with an antipsychotic potential, on circulating prolactin levels in male rats

J. Liégeois, J. Legros, J. Bruhwyler, 2002, Neuroscience Letters.

JL 13, a potential successor to clozapine, is less sensitive to oxidative phenomena.

J. Liégeois, J. Kauffmann, A. Mouithys-Mickalad, 1997, Biochemical and biophysical research communications.

JL 13, an atypical antipsychotic: a preclinical review.

B. Ellenbroek, J. Liégeois, 2003, CNS drug reviews.

Pyridobenzoxazepine and pyridobenzothiazepine derivatives as potential central nervous system agents: synthesis and neurochemical study.

J. Liégeois, T. P. Nguyen, J. Bruhwyler, 1994, Journal of medicinal chemistry.

Electrooxidation potential as a tool in the early screening for new safer clozapine-like analogues.

H. Wikström, G. Deby-dupont, J. Liégeois, 2001, Journal of medicinal chemistry.

JL13, a pyridobenzoxazepine compound with potential atypical antipsychotic activity: a review of its behavioural properties.

H. Meltzer, J. Liégeois, J. Bergman, 1997, Pharmacological research.

Diarylazepine Derivatives as Potent Atypical Neuroleptic Drugs: Recent Advances

J. Liégeois, J. Bruhwyler, J. Delarge, 1995, Current Medicinal Chemistry.

Synthesis and radioligand binding studies of C-5- and C-8-substituted 1-(3,4-dimethoxybenzyl)-2,2-dimethyl-1,2,3,4-tetrahydroisoquinoliniums as SK channel blockers related to N-methyl-laudanosine and N-methyl-noscapine.

J. Scuvée-Moreau, J. Liégeois, V. Seutin, 2005, Journal of medicinal chemistry.

A rapid synthesis of thieno[2,3-c]pyridine and 2-substituted thieno[2,3-c]pyridines

J. Liégeois, A. Graulich, 2004 .

(+/-)-2-Benzoyl-8-ethyl-1,2-dihydro-isoquinoline-1-carbonitrile: an original Reissert compound

B. Norberg, J. Wouters, J. Liégeois, 2007 .

Bis-tetrahydroisoquinoline derivatives: AG525E1, a new step in the search for non-quaternary non-peptidic small conductance Ca(2+)-activated K(+) channel blockers.

J. Wouters, P. Chavatte, Cédric Lamy, 2008, Bioorganic & medicinal chemistry letters.

Synthesis and radioligand binding studies of methoxylated 1,2,3,4-tetrahydroisoquinolinium derivatives as ligands of the apamin-sensitive Ca2+-activated K+ channels.

J. Scuvée-Moreau, Cédric Lamy, J. Liégeois, 2006, Journal of medicinal chemistry.

Structural analysis of some bis-(8-isopropyl-isoquinolinium) derivatives reveals a preferential folded conformation leading to a stereoselective attack by sodium borohydride

J. Wouters, P. Hubert, S. Dilly, 2014 .

New pyridobenzodiazepine derivatives as potential antipsychotics: synthesis and neurochemical study.

J. Liégeois, T. P. Nguyen, J. Bruhwyler, 1993, Journal of medicinal chemistry.

Effective resolution of racemic pirlindole at the preparative scale

P. Tullio, P. Hubert, J. Liégeois, 1998 .

Nitric oxide: A new messenger in the brain

J. Liégeois, J. Bruhwyler, E. Chleide, 1993, Neuroscience & Biobehavioral Reviews.

Ligand effects in the hydrogenation of methacycline to doxycycline and epi-doxycycline catalysed by rhodium complexes molecular structure of the key catalyst [closo-3,3-(η2,3-C7H7CH2)-3,1,2-RhC2B9H11]

J. Liégeois, B. Pirotte, V. Bregadze, 1997 .

The inclusion of fluoxetine into γ-cyclodextrin increases its bioavailability: behavioural, electrophysiological and pharmacokinetic studies

J. Scuvée-Moreau, A. Dresse, L. Szente, 2000, Psychopharmacology.

Modulation of small conductance calcium-activated potassium (SK) channels: a new challenge in medicinal chemistry.

J. Scuvée-Moreau, J. Liégeois, V. Seutin, 2003, Current medicinal chemistry.

SK channel blockade promotes burst firing in dorsal raphe serotonergic neurons

Jean-François Liégeois, Vincent Seutin, Laurent Massotte, 2008, The European journal of neuroscience.

Enantiomeric separation of pirlindole by liquid chromatography using different types of chiral stationary phases.

P. Hubert, J. Liégeois, A. Ceccato, 1998, Journal of pharmaceutical and biomedical analysis.

An unconventional conductance is required for pacemaking of nigral dopamine neurons

J. Roeper, D. Engel, J. Liégeois, 2020, bioRxiv.

Novel inhibitors of the sodium-calcium exchanger: benzene ring analogues of N-guanidino substituted amiloride derivatives.

B. Masereel, J. Liégeois, A. Herchuelz, 2001, European journal of medicinal chemistry.

Development and validation of a high-performance liquid chromatographic method for the determination of cyproterone acetate in human skin.

Philippe Hubert, Patrice Chiap, Jacques Crommen, 2004, Journal of pharmaceutical and biomedical analysis.

Modulation of the clozapine structure increases its selectivity for the dopamine D4 receptor.

B. Masereel, J. Liégeois, B Masereel, 1995, European journal of pharmacology.

Long-term Effects of JL 13, a Potential Atypical Antipsychotic, on Ionotropic Glutamate Receptors

F. Tarazi, Cédric Lamy, J. Liégeois, 2007, Journal of Molecular Neuroscience.

Effects of JL13, a pyridobenzoxazepine with potential atypical antipsychotic activity, in animal models for schizophrenia.

A. Cools, B. Ellenbroek, J. Liégeois, 2001, The Journal of pharmacology and experimental therapeutics.

Antipsychotics and neuropeptides: The atypical profile of CI-943 and its relationship to neurotensin

P. Bonaventure, J. Liégeois, J. Damas, 1995, Neuroscience & Biobehavioral Reviews.

Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part I: Influence of the substitution on the basic nitrogen and the position of the amide on the affinity for D2L, D4.2, and 5-HT2A receptors.

B. Roth, Niels H. Jensen, J. Liégeois, 2007, Bioorganic & medicinal chemistry letters.

Metaplastic effect of apamin on LTP and paired-pulse facilitation.

E. Godaux, Coralie Sclavons, J. Liégeois, 2007, Learning & memory.

M-type channels selectively control bursting in rat dopaminergic neurons

Maxime Bonjean, Rodolphe Sepulchre, Jean-François Liégeois, 2010, The European journal of neuroscience.

SK channels control the firing pattern of midbrain dopaminergic neurons in vivo

Jean-François Liégeois, Vincent Seutin, Laurent Massotte, 2005, The European journal of neuroscience.

Allosteric Block of KCa2 Channels by Apamin*

D. Jane, N. Marrion, Cédric Lamy, 2010, The Journal of Biological Chemistry.

Facilitatory effects of chronically administered citicoline on learning and memory processes in the dog

J. Liégeois, J. Bruhwyler, J. Géczy, 1998, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Crucial role of a shared extracellular loop in apamin sensitivity and maintenance of pore shape of small-conductance calcium-activated potassium (SK) channels

N. Marrion, J. Liégeois, V. Seutin, 2011, Proceedings of the National Academy of Sciences.

Molecular modeling study of 4-phenylpiperazine and 4-phenyl-1,2,3,6-tetrahydropyridine derivatives: a new step towards the design of high-affinity 5-HT1A ligands.

S. Dilly, J. Liégeois, A. Graulich, 2010, Bioorganic & medicinal chemistry letters.

The 5-HT1A Agonism Potential of Substituted Piperazine-Ethyl-Amide Derivatives Is Conserved in the Hexyl Homologues: Molecular Modeling and Pharmacological Evaluation

Sébastien Dilly, Jean-François Liégeois, Jacqueline Scuvée-Moreau, 2011, J. Chem. Inf. Model..

Interaction of clozapine and its nitrenium ion with rat D2 dopamine receptors: in vitro binding and computational study

Sébastien Dilly, Jean-François Liégeois, S. Dilly, 2011, J. Comput. Aided Mol. Des..

Simultaneous determination of pirlindole enantiomers and dehydropirlindole by chiral liquid chromatography.

P. Hubert, J. Liégeois, A. Ceccato, 1998, Journal of pharmaceutical and biomedical analysis.

First preparative enantiomer resolution of pirlindole, a potent antidepressant drug

P. Tullio, P. Hubert, J. Liégeois, 1998 .

Anxiolytic potential of sulpiride, clozapine and derivatives in the open-field test

J. Liégeois, J. Bruhwyler, E. Chleide, 1990, Pharmacology Biochemistry and Behavior.

Long‐term effects of JL 13, a potential atypical antipsychotic, on rat dopamine and serotonin receptor subtypes

F. Tarazi, J. Liégeois, A. Graulich, 2006, Journal of neuroscience research.

Structural Insights into 5-HT1A/D4 Selectivity of WAY-100635 Analogues: Molecular Modeling, Synthesis, and in Vitro Binding

Sébastien Dilly, Jean-François Liégeois, S. Dilly, 2016, J. Chem. Inf. Model..

Moderate chemical modifications of WAY-100635 improve the selectivity for 5-HT1A versus D4 receptors.

V. Setola, B. Roth, J. Scuvée-Moreau, 2012, Bioorganic & medicinal chemistry letters.

The interactions of apamin and tetraethylammonium are differentially affected by single mutations in the pore mouth of small conductance calcium-activated potassium (SK) channels.

D. Snyders, Cédric Lamy, S. Dilly, 2013, Biochemical pharmacology.

Ion‐Channel Modulators: More Diversity Than Previously Thought

N. Marrion, Cédric Lamy, S. Dilly, 2011, Chembiochem : a European journal of chemical biology.

5-HT2A receptor antagonism potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and inhibits that in the nucleus accumbens in a dose-dependent manner

H. Meltzer, J. Liégeois, J. Ichikawa, 2002, Brain Research.

Synthesis and in vitro binding studies of piperazine-alkyl-naphthamides: impact of homology and sulphonamide/carboxamide bioisosteric replacement on the affinity for 5-HT1A, alpha2A, D4.2, D3 and D2L receptors.

Jean-François Liégeois, J. Liégeois, Mélissa Résimont, 2010, Bioorganic & medicinal chemistry letters.

Methyl-laudanosine: a new pharmacological tool to investigate the function of small-conductance Ca(2+)-activated K(+) channels.

J. Scuvée-Moreau, J. Liégeois, V. Seutin, 2002, The Journal of pharmacology and experimental therapeutics.

Crystal structure of bis(8-chloro-5-(4-methylpiperazinium-1-yl)pyrido- [2,3-b][1,5]benzoxazepine) fumarate - fumaric acid solvate (1:1), (C17H18ClN4O)2(C4H2O4) · C4H4O4

J. Liégeois, L. Dupont, 2004 .

Crystal structure of bis(8-chloro-5-(4-methylpiperazinium-1-yl)pyrido- [2,3-b][1,5]benzoxazepine) fumarate – fumaric acid solvate (1:1), (C17H18ClN4O)2(C4H2O4) · C4H4O4

J. Liégeois, L. Dupont, 2004 .

Hypochlorous Acid, a Major Oxidant Produced by Activated Neutrophils, Has Low Effect on Two Pyridobenzazepine Derivatives, JL 3 and JL 13

J. Liégeois, J. Uetrecht, N. Zahid, 2000, Archiv der Pharmazie.

New dibenzazepine derivatives with disinhibitory and/or antidepressant potential: neurochemical and behavioural study in the open‐field and forced swimming tests

J. Liégeois, J. Bruhwyler, J. Géczy, 1995, Behavioural pharmacology.

Comparative study of typical neuroleptics, clozapine and newly synthesized clozapine‐analogues: correlations between neurochemistry and behaviour

J. Liégeois, J. Bruhwyler, M. Mercier, 1992, Behavioural pharmacology.

Electrophysiological characterization of the SK channel blockers methyl‐laudanosine and methyl‐noscapine in cell lines and rat brain slices

J. Scuvée-Moreau, M. Stocker, J. Liégeois, 2004, British journal of pharmacology.

Effects of specific dopaminergic agonists and antagonists in the open-field test

J. Liégeois, J. Bruhwyler, E. Chleide, 1991, Pharmacology Biochemistry and Behavior.

Pirlindole: a selective reversible inhibitor of monoamine oxidase A. A review of its preclinical properties.

J. Liégeois, J. Bruhwyler, J. Géczy, 1997, Pharmacological research.

Identification of a pharmacophore of SKCa channel blockers

P. Chavatte, A. Farce, S. Dilly, 2005, Journal of enzyme inhibition and medicinal chemistry.

SK channels are on the move

J. Liégeois, V. Seutin, 2007, British journal of pharmacology.

Le controle du reseau vasculaire cutane

N. Garbacki, J. Liégeois, J. Juchmes, 2001 .

[Control of cutaneous blood vessels].

N. Garbacki, J. Liégeois, J. Juchmes, 2001, Revue medicale de Liege.

The gating pore blocker 1-(2,4-xylyl)guanidinium selectively inhibits pacemaking of midbrain dopaminergic neurons

J. Roeper, D. Engel, J. Liégeois, 2021, Neuropharmacology.

Chemical modifications of the N-methyl-laudanosine scaffold point to new directions for SK channels exploration.

J. Wouters, S. Dilly, J. Liégeois, 2014, Bioorganic & medicinal chemistry letters.

5-HT(2A) receptor antagonism potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and inhibits that in the nucleus accumbens in a dose-dependent manner.

H. Meltzer, J. Liégeois, J. Ichikawa, 2002, Brain Research.