Jian Hui Wu

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Model of Inflammatory Arthritis Inflammation As Demonstrated in a Murine Potent Inhibitor of CCR2-Driven An Engineered GM-CSF-CCL2 Fusokine Is a

N. Heveker, Yamina A Berchiche, J. Galipeau, 2009 .

An Engineered GM-CSF-CCL2 Fusokine Is a Potent Inhibitor of CCR2-Driven Inflammation As Demonstrated in a Murine Model of Inflammatory Arthritis1

N. Heveker, Yamina A Berchiche, J. Galipeau, 2009, The Journal of Immunology.

Structure-Based Identification of Novel Human γ-Glutamylcysteine Synthetase Inhibitors

Gerald Batist, G. Batist, Jian Hui Wu, 2007, Molecular Pharmacology.

Mining Natural Product-Derived Molecules Against Cancer Targets: The Case of the Androgen Receptor in Prostate Cancer

Jian Hui Wu, 2010 .

A GMCSF and IL-15 fusokine leads to paradoxical immunosuppression in vivo via asymmetrical JAK/STAT signaling through the IL-15 receptor complex.

Borhane Annabi, Jacques Galipeau, B. Annabi, 2006, Blood.

Glutathione and glutathione analogues; therapeutic potentials.

G. Batist, Jian Hui Wu, 2013, Biochimica et biophysica acta.

Design and synthesis of androgen receptor antagonists with bulky side chains for overcoming antiandrogen resistance.

Jinming Zhou, Jian Hui Wu, F. Sauriol, 2009, Journal of medicinal chemistry.

Syntheses and potential anti-prostate cancer activities of ionone-based chalcones.

G. Batist, Jinming Zhou, Jian Hui Wu, 2009, Bioorganic & medicinal chemistry letters.

Synthesis and in vitro characterization of ionone-based chalcones as novel antiandrogens effective against multiple clinically relevant androgen receptor mutants

Jinming Zhou, Jian Hui Wu, Guoyan Geng, 2010, Investigational New Drugs.

Impact of EGFR point mutations on the sensitivity to gefitinib: Insights from comparative structural analyses and molecular dynamics simulations

Jian Hui Wu, Bing Liu, Brandon Bernard, 2006, Proteins.

GM-CSF and IL-4 Fusion Cytokine Induces B Cell-Dependent Hematopoietic Regeneration.

Jiusheng Deng, A. Pennati, J. Galipeau, 2017, Molecular therapy : the journal of the American Society of Gene Therapy.

Synthesis and in vitro characterization of ionone-based compounds as dual inhibitors of the androgen receptor and NF-κB

Jinming Zhou, Jian Hui Wu, R. Lin, 2014, Investigational New Drugs.

Triptolide-mediated inhibition of interferon signaling enhances vesicular stomatitis virus-based oncolysis.

J. van Grevenynghe, J. Hiscott, Jian Hui Wu, 2013, Molecular therapy : the journal of the American Society of Gene Therapy.

Identification and Characterization of Novel Nrf2 Inducers Designed to Target the Intervening Region of Keap1

G. Batist, Jian Hui Wu, W. Miao, 2010, Chemical biology & drug design.

Engineered fusokine GIFT4 licenses the ability of B cells to trigger a tumoricidal T-cell response.

Jiusheng Deng, A. Pennati, J. Galipeau, 2014, Cancer research.

Selective Inhibition of CCR2 Expressing Lymphomyeloid Cells in Experimental Autoimmune Encephalomyelitis by a GM-CSF-MCP1 Fusokine1

Philippe M. Campeau, J. Galipeau, M. Rafei, 2009, The Journal of Immunology.

Design and syntheses of putative bioactive taxanes.

G. Batist, Jian Hui Wu, L. Zamir, 2002, Bioorganic & medicinal chemistry.

Sophoraflavenone G Restricts Dengue and Zika Virus Infection via RNA Polymerase Interference

M. Wainberg, Jian Hui Wu, Long Yang, 2017, Viruses.

Tanshinone derivatives: a patent review (January 2006 – September 2012)

Jian Hui Wu, Xiaohong Tian, 2013, Expert opinion on therapeutic patents.

The androgen receptor gene mutations database (ARDB): 2004 update

Jian Hui Wu, B. Gottlieb, M. Trifiro, 2004, Human mutation.

Differential metastasis-associated gene analysis of prostate carcinoma cells derived from primary tumor and spontaneous lymphatic metastasis in nude mice with orthotopic implantation of PC-3M cells.

Jian Hui Wu, X-L Meng, Xiu-rong Jiang, 2006, Cancer letters.

Hyperoside alleviates toxicity of β-amyloid via endoplasmic reticulum-mitochondrial calcium signal transduction cascade in APP/PS1 double transgenic Alzheimer's disease mice

Xi Chen, Jian Hui Wu, V. Wong, 2023, Redox biology.

Bridging structural biology and genetics by computational methods: An investigation into how the R774C mutation in the AR gene can result in complete androgen insensitivity syndrome

E. Purisima, G. Batist, T. Sulea, 2003, Human mutation.

Periostin, a Member of a Novel Family of Vitamin K-dependent Proteins, Is Expressed by Mesenchymal Stromal Cells*

M. Blostein, D. Coutu, J. Galipeau, 2008, Journal of Biological Chemistry.

Cyclophosphamides as hypoxia-activated diffusible cytotoxins: A theoretical study

Jian Hui Wu, Christopher A. Reynolds, C. Reynolds, 2000, J. Comput. Aided Mol. Des..

Resistance to Cancer Treatment: The Role of Somatic Genetic Events and the Challenges for Targeted Therapies

W. Miller, G. Batist, M. Basik, 2011, Front. Pharmacol..

A novel missense mutation in the gamma-glutamylcysteine synthetase catalytic subunit gene causes both decreased enzymatic activity and glutathione production.

G. Batist, Jian Hui Wu, M. Alaoui-Jamali, 2003, Blood.

Binding-Site Match Maker (BSMM): A Computational Method for the Design of Multi-Target Ligands

Jian Hui Wu, Jinming Zhou, Jinming Zhou, 2020, Molecules.

Effect of Mono-2-ethyhexyl Phthalate on DNA Methylation in Human Prostate Cancer LNCaP Cells.

Yan Zhao, Jian Hui Wu, Jiao Chen, 2017, Biomedical and environmental sciences : BES.

GIFT4 fusokine converts leukemic B cells into immune helper cells

C. Flowers, Jiusheng Deng, A. Pennati, 2016, Journal of Translational Medicine.

A GMCSF and IL7 fusion cytokine leads to functional thymic-dependent T-cell regeneration in age-associated immune deficiency

J. Galipeau, Jian Hui Wu, G. Tharp, 2015, Clinical & translational immunology.

B. Annabi, L. Lejeune, J. Galipeau, 2006 .

Solute polarization and the design of cobalt complexes as redox-active therapeutic agents

C. Reynolds, P. Winn, Jian Hui Wu, 1999 .

Antiandrogenic, maspin induction, and antiprostate cancer activities of tanshinone IIA and its novel derivatives with modification in ring A.

Jinming Zhou, Jian Hui Wu, F. Sauriol, 2012, Journal of medicinal chemistry.

Learning From Estrogen Receptor Antagonism: Structure‐Based Identification of Novel Antiandrogens Effective Against Multiple Clinically Relevant Androgen Receptor Mutants

Jian Hui Wu, R. Lin, Guoyan Geng, 2012, Chemical biology & drug design.

An examination of how different mutations at arginine 855 of the androgen receptor result in different androgen insensitivity phenotypes.

G. Batist, Jian Hui Wu, B. Gottlieb, 2004, Molecular endocrinology.

The use of androgen receptor amino/carboxyl-terminal interaction assays to investigate androgen receptor gene mutations in subjects with varying degrees of androgen insensitivity.

Jian Hui Wu, L. Pinsky, B. Gottlieb, 2003, The Journal of clinical endocrinology and metabolism.

Study of the impact of the T877A mutation on ligand‐induced helix‐12 positioning of the androgen receptor resulted in design and synthesis of novel antiandrogens

Jinming Zhou, Jian Hui Wu, Guoyan Geng, 2010, Proteins.

Granulocyte-Macrophage Colony-Stimulating Factor and Interleukin-2 Fusion cDNA for Cancer Gene Immunotherapy

J. Galipeau, Jian Hui Wu, J. Stagg, 2004, Cancer Research.

Discovery of a Small-Molecule Inhibitor Targeting the Androgen Receptor N-Terminal Domain for Castration-Resistant Prostate Cancer.

Jun Luo, Jian Hui Wu, R. Lin, 2023, Molecular cancer therapeutics.

Structure-based identification of novel human gamma-glutamylcysteine synthetase inhibitors.

G. Batist, Jian Hui Wu, D. Hamilton, 2007, Molecular Pharmacology.