Y. Higuchi

发表

Immunostimulatory characteristics induced by linear polyethyleneimine-plasmid DNA complexes in cultured macrophages.

S. Kawakami, M. Hashida, F. Yamashita, 2008, Human gene therapy.

Development of lysine-histidine dendron modified chitosan for improving transfection efficiency in HEK293 cells.

S. Kawakami, M. Hashida, F. Yamashita, 2011, Journal of controlled release : official journal of the Controlled Release Society.

Synthesis and Functional Characterization of Novel Sialyl LewisX Mimic-Decorated Liposomes for E-selectin-Mediated Targeting to Inflamed Endothelial Cells.

S. Kawakami, M. Hashida, F. Yamashita, 2017, Molecular pharmaceutics.

NFkappaB decoy delivery using dendritic poly(l-lysine) for treatment of endotoxin-induced hepatitis in mice.

S. Kawakami, M. Hashida, T. Niidome, 2009, Bioorganic & medicinal chemistry.

Intravital imaging of live mice at cellular resolution

M. Hashida, Y. Higuchi, Sota Yamada, 2016 .

Encapsulation of the synthetic retinoids Am80 and LE540 into polymeric micelles and the retinoids' release control.

S. Kawakami, M. Hashida, M. Yokoyama, 2009, Journal of controlled release : official journal of the Controlled Release Society.

Biodistribution characteristics of mannosylated and fucosylated O/W emulsions in mice

S. Kawakami, M. Hashida, F. Yamashita, 2005, Journal of drug targeting.

Title piggyBac transposon-mediated long-term gene expression in mice

S. Kawakami, F. Yamashita, Y. Higuchi, 2019 .

piggyBac Transposon-mediated Long-term Gene Expression in Mice

S. Kawakami, M. Hashida, F. Yamashita, 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

Neutralized Nanoparticle Composed of SS‐Cleavable and pH‐Activated Lipid‐Like Material as a Long‐Lasting and Liver‐Specific Gene Delivery System

S. Konishi, K. Shimizu, M. Hashida, 2014, Advanced healthcare materials.

The potential role of fucosylated cationic liposome/NFkappaB decoy complexes in the treatment of cytokine-related liver disease.

S. Kawakami, M. Hashida, F. Yamashita, 2007, Biomaterials.

Intravenous administration of mannosylated cationic liposome/NFκB decoy complexes effectively prevent LPS‐induced cytokine production in a murine liver failure model

S. Kawakami, M. Hashida, F. Yamashita, 2006, FEBS letters.

Kidney-selective gene transfection using anionic bubble lipopolyplexes with renal ultrasound irradiation in mice.

S. Kawakami, M. Hashida, F. Yamashita, 2014, Nanomedicine : nanotechnology, biology, and medicine.

Development of a suction device for stabilizing in vivo real-time imaging of murine tissues.

S. Konishi, K. Shimizu, M. Hashida, 2011, Journal of bioscience and bioengineering.

Antitumor effect of nuclear factor-κB decoy transfer by mannose-modified bubble lipoplex into macrophages in mouse malignant ascites

S. Kawakami, M. Hashida, F. Yamashita, 2014, Cancer science.

Factors influencing the surface modification of mesenchymal stem cells with fluorescein-pegylated lipids.

S. Kawakami, M. Hashida, F. Yamashita, 2013, Biological & pharmaceutical bulletin.

Development of fluorous lipid-based nanobubbles for efficiently containing perfluoropropane.

S. Kawakami, M. Hashida, F. Yamashita, 2015, International journal of pharmaceutics.

Pharmacokinetics of Nanocarrier-Mediated Drug and Gene Delivery

S. Kawakami, M. Hashida, Y. Higuchi, 2006 .

[Controlling Cell Dynamics by Cell-surface Modification].

Y. Higuchi, Yoshimasa Takafuji, 2021, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Evaluation of inflammatory responses due to small interfering RNA transfer using unmodified- and mannose-modified bubble lipoplexes with ultrasound exposure in primary cultured macrophages

S. Kawakami, M. Hashida, F. Yamashita, 2014, Journal of drug targeting.

Enhanced Anti-Inflammation of Inhaled Dexamethasone Palmitate Using Mannosylated Liposomes in an Endotoxin-Induced Lung Inflammation Model

S. Kawakami, M. Hashida, H. Sasaki, 2008, Molecular Pharmacology.

Microsoft Word-83211850-file00

S. Kawakami, M. Hashida, Mugen Teshima, 2008 .

The development of mechanically formed stable nanobubbles intended for sonoporation-mediated gene transfection

S. Kawakami, M. Hashida, F. Yamashita, 2017, Drug delivery.

Development of mKO2 fusion proteins for real-time imaging and mechanistic investigation of the degradation kinetics of human IκBα in living cells.

M. Hashida, F. Yamashita, Y. Higuchi, 2019, Biochimica et biophysica acta. Molecular cell research.

Evaluation of long-term gene expression in mouse liver using PhiC31 integrase and hydrodynamic injection.

S. Kawakami, M. Hashida, F. Yamashita, 2012, Biological & pharmaceutical bulletin.

[Development of cell-selective targeting systems of NFkappaB decoy for inflammation therapy].

S. Kawakami, M. Hashida, Y. Higuchi, 2008, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Suppressive effects of sugar-modified cationic liposome/NF-kappaB decoy complexes on adenovirus vector-induced innate immune responses.

S. Kawakami, M. Hashida, H. Mizuguchi, 2009, Journal of controlled release : official journal of the Controlled Release Society.

Intracellular distribution of NFκB decoy and its inhibitory effect on TNFα production by LPS stimulated RAW 264.7 cells

S. Kawakami, M. Hashida, F. Yamashita, 2005 .

Intratracheally instilled mannosylated cationic liposome/NFκB decoy complexes for effective prevention of LPS-induced lung inflammation.

S. Kawakami, M. Hashida, F. Yamashita, 2011, Journal of controlled release : official journal of the Controlled Release Society.

Tumour-associated macrophages targeted transfection with NF-κB decoy/mannose-modified bubble lipoplexes inhibits tumour growth in tumour-bearing mice

S. Kawakami, M. Hashida, F. Yamashita, 2014, Journal of drug targeting.

Uptake characteristics of mannosylated and fucosylated bovine serum albumin in primary cultured rat sinusoidal endothelial cells and Kupffer cells.

S. Kawakami, M. Hashida, F. Yamashita, 2004, International journal of pharmaceutics.

Disposition of E-selectin-targeting liposomes in tumor spheroids with a perfusable vascular network.

F. Yamashita, Y. Higuchi, R. Yokokawa, 2022, Drug metabolism and pharmacokinetics.

Bovine serum albumin as a lyoprotectant for preparation of DNA dry powder formulations using the spray-freeze drying method.

S. Kawakami, M. Hashida, F. Yamashita, 2012, Biological & pharmaceutical bulletin.

The involvement of NK cell activation following intranasal administration of CpG DNA lipoplex in the prevention of pulmonary metastasis and peritoneal dissemination in mice

S. Kawakami, M. Hashida, F. Yamashita, 2011, Clinical & Experimental Metastasis.

Evaluation of Osteoclastogenesis via NFκB Decoy/mannosylated Cationic Liposome-Mediated Inhibition of Pro-inflammatory Cytokine Production from Primary Cultured Macrophages

S. Kawakami, M. Hashida, F. Yamashita, 2011, Pharmaceutical Research.

A SIMPLE PDMS-BASED SUCTION DEVICE FOR STABILIZING IN VIVO REAL-TIME FLUORESCENCE IMAGING OF TRANSPLANTED CELLS IN LIVE ANIMALS

S. Konishi, K. Shimizu, M. Hashida, 2011 .

Oligonuleotide delivery with dendritic poly(L-lysine) for treatments of the liver disorders

S. Kawakami, M. Hashida, T. Niidome, 2009 .

In vitro evaluation of inhibitory effect of nuclear factor-kappaB activity by small interfering RNA on pro-tumor characteristics of M2-like macrophages.

S. Kawakami, M. Hashida, F. Yamashita, 2014, Biological & pharmaceutical bulletin.

Enhanced gene transfection in macrophages by histidine-conjugated mannosylated cationic liposomes.

S. Kawakami, M. Hashida, Hidefumi Mukai, 2009, Biological & pharmaceutical bulletin.

Efficient gene transfection by histidine-modified chitosan through enhancement of endosomal escape.

S. Kawakami, M. Hashida, F. Yamashita, 2010, Bioconjugate chemistry.

Application of perfluoropolyether elastomers in microfluidic drug metabolism assays.

F. Yamashita, Y. Torisawa, Kazuo Takayama, 2022, International journal of pharmaceutics.

Comparison of piggyBac transposition efficiency between linear and circular donor vectors in mammalian cells.

S. Kawakami, M. Hashida, F. Yamashita, 2011, Journal of Biotechnology.

Effect of the particle size of galactosylated lipoplex on hepatocyte-selective gene transfection after intraportal administration.

S. Kawakami, M. Hashida, F. Yamashita, 2006, Biological & pharmaceutical bulletin.

Cellular Calcium Oscillations in Droplets with Different Chemical Concentrations Supplied by Droplet-Array Sandwiching Technology

S. Konishi, Y. Higuchi, Asuka Tamayori, 2022, Sensors and Actuators B: Chemical.

Sialyl LewisX mimic-decorated liposomes for anti-angiogenic everolimus delivery to E-selectin expressing endothelial cells

M. Hashida, F. Yamashita, Y. Higuchi, 2019, RSC advances.

Development of cancer immune therapy by cell targeted nucleic acid delivery

S. Kawakami, M. Hashida, Y. Hattori, 2008 .

Anti-inflammatory Effect of Self-assembling Glycol-Split Glycosaminoglycan-Stearylamine Conjugates in Lipopolysaccharide-Stimulated Macrophages.

M. Hashida, F. Yamashita, Y. Higuchi, 2017, Biological & pharmaceutical bulletin.

A model-based comparative meta-analysis of the efficacy of dolutegravir-based and efavirenz-based regimens in HIV-infected patients.

F. Yamashita, Y. Higuchi, M. Tsuda, 2019, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.

Use of Membrane Potential to Achieve Transmembrane Modification with an Artificial Receptor.

H. Ohshima, M. Hashida, A. Kishimura, 2017, Bioconjugate chemistry.

The involvement of NK cell activation following intranasal administration of CpG DNA lipoplex in the prevention of pulmonary metastasis and peritoneal dissemination in mice

S. Kawakami, M. Hashida, F. Yamashita, 2011, Clinical & Experimental Metastasis.

Effect of cationic charge on receptor-mediated transfection using mannosylated cationic liposome/plasmid DNA complexes following the intravenous administration in mice.

S. Kawakami, M. Hashida, F. Yamashita, 2004, Die Pharmazie.

PD-L1/L2 protein levels rapidly increase on monocytes via trogocytosis from tumor cells in classical Hodgkin lymphoma

K. Katagiri, K. Okuyama, T. Kitamura, 2020, Leukemia.

Strategies for In Vivo Delivery of siRNAs

S. Kawakami, M. Hashida, Y. Higuchi, 2010, BioDrugs.

Luminescent proteins for high-speed single-cell and whole-body imaging

Takeharu Nagai, Mitsuru Hashida, Tomoki Matsuda, 2012, Nature Communications.

Involvement of serum mannan binding proteins and mannose receptors in uptake of mannosylated liposomes by macrophages.

S. Kawakami, M. Hashida, F. Yamashita, 2001, Biochimica et biophysica acta.

Polyamidoamine dendrimer-conjugated quantum dots for efficient labeling of primary cultured mesenchymal stem cells.

S. Kawakami, M. Hashida, F. Yamashita, 2011, Biomaterials.

Novel histidine-conjugated galactosylated cationic liposomes for efficient hepatocyte-selective gene transfer in human hepatoma HepG2 cells.

S. Kawakami, M. Hashida, F. Yamashita, 2007, Journal of controlled release : official journal of the Controlled Release Society.

Self-assemble gene delivery system for molecular targeting using nucleic acid aptamer.

S. Kawakami, M. Hashida, H. Sasaki, 2012, Gene.

Enhancement of the anti-tumor effect of DNA vaccination using an ultrasound-responsive mannose-modified gene carrier in combination with doxorubicin-encapsulated PEGylated liposomes.

S. Kawakami, M. Hashida, F. Yamashita, 2014, International journal of pharmaceutics.

Enhanced growth inhibition of metastatic lung tumors by intravenous injection of ATRA-cationic liposome/IL-12 pDNA complexes in mice

S. Kawakami, M. Hashida, F. Yamashita, 2010, Cancer Gene Therapy.

Systemic Targeting of Lymph Node Metastasis through the Blood Vascular System by Using Size-Controlled Nanocarriers.

S. Konishi, Takahiro Nomoto, K. Toh, 2015, ACS nano.

Injectable prevascularized mature adipose tissues (iPAT) to achieve long-term survival in soft tissues regeneration

M. Matsusaki, Y. Sowa, Y. Higuchi, 2020, bioRxiv.

Prediction of HIV drug resistance based on the 3D protein structure: Proposal of molecular field mapping

F. Yamashita, Y. Higuchi, Ryosaku Ota, 2021, PloS one.

Mannosylated semiconductor quantum dots for the labeling of macrophages.

S. Kawakami, M. Hashida, Y. Higuchi, 2008, Journal of controlled release : official journal of the Controlled Release Society.

Nonviral approaches for targeted delivery of plasmid DNA and oligonucleotide.

S. Kawakami, M. Hashida, Y. Higuchi, 2008, Journal of pharmaceutical sciences.

Enhanced in vivo antitumor efficacy of fenretinide encapsulated in polymeric micelles.

S. Kawakami, M. Hashida, F. Yamashita, 2009, International journal of pharmaceutics.

Incorporation of all‐trans retinoic acid into lipoplexes inhibits nuclear factor κB activation mediated liver injury induced by lipoplexes in mice

S. Kawakami, M. Hashida, Y. Higuchi, 2008, The journal of gene medicine.

Interaction with Blood Components Plays a Crucial Role in Asialoglycoprotein Receptor-Mediated in Vivo Gene Transfer by Galactosylated Lipoplex

S. Kawakami, M. Hashida, F. Yamashita, 2005, Journal of Pharmacology and Experimental Therapeutics.

Photothermic regulation of gene expression triggered by laser-induced carbon nanohorns

M. Hashida, F. Yamashita, M. Yudasaka, 2012, Proceedings of the National Academy of Sciences.

Development of anionic bubble lipopolyplexes for efficient and safe gene transfection with ultrasound exposure in mice.

S. Kawakami, M. Hashida, F. Yamashita, 2014, Journal of controlled release : official journal of the Controlled Release Society.

Development of optical imaging to visualize dynamics of cells in vivo

Y. Higuchi, 2013 .

[Development of fluorescent labeling methods for stem cells].

Y. Higuchi, 2012, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Efficient suppression of murine intracellular adhesion molecule‐1 using ultrasound‐responsive and mannose‐modified lipoplexes inhibits acute hepatic inflammation

S. Kawakami, M. Hashida, F. Yamashita, 2012, Hepatology.

Involvement of activated transcriptional process in efficient gene transfection using unmodified and mannose-modified bubble lipoplexes with ultrasound exposure.

S. Kawakami, M. Hashida, F. Yamashita, 2011, Journal of controlled release : official journal of the Controlled Release Society.

Gamma-polyglutamic acid-coated vectors for effective and safe gene therapy.

S. Kawakami, M. Hashida, T. Hamamoto, 2010, Journal of controlled release : official journal of the Controlled Release Society.

[Development and therapeutic application of transposon-based vectors].

S. Kawakami, M. Hashida, F. Yamashita, 2009, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Targeted gene integration using the combination of a sequence-specific DNA-binding protein and phiC31 integrase.

M. Hashida, F. Yamashita, Y. Higuchi, 2014, Journal of biotechnology.

An Evolutionary Search Algorithm for Covariate Models in Population Pharmacokinetic Analysis.

Fumiyoshi Yamashita, Mitsuru Hashida, Masahiro Tsuda, 2017, Journal of pharmaceutical sciences.

Journal of Controlled Release Original Article Γ-polyglutamic Acid-coated Vectors for Effective and Safe Gene Therapy

T. Hamamoto, Hiroo Nakagawa, Yukinobu Kodama, 2017 .

Programmed immobilization of living cells using independent click pairs.

Y. Higuchi, Chengyuan Zhu, Hiroyasu Takemoto, 2024, Biochemical and biophysical research communications.

Intestinal Permeability of Drugs in Caco-2 Cells Cultured in Microfluidic Devices.

F. Yamashita, Y. Torisawa, Y. Higuchi, 2022, Biological & pharmaceutical bulletin.

Evaluation of Osteoclastogenesis via NFκB Decoy/mannosylated Cationic Liposome-Mediated Inhibition of Pro-inflammatory Cytokine Production from Primary Cultured Macrophages

S. Kawakami, M. Hashida, F. Yamashita, 2011, Pharmaceutical Research.