C. Galés

发表

Functional Selectivity of Natural and Synthetic Prostaglandin EP4 Receptor Ligands

N. Heveker, M. Leduc, M. Bouvier, 2009, Journal of Pharmacology and Experimental Therapeutics.

CODA-RET reveals functional selectivity as a result of GPCR heteromerization

J. Javitch, N. Lambert, R. Kolster, 2011, Nature chemical biology.

Evidence for a Direct Interaction between the Penultimate Aspartic Acid of Cholecystokinin and Histidine 207, Located in the Second Extracellular Loop of the Cholecystokinin B Receptor*

B. Maigret, N. Vaysse, S. Silvente-Poirot, 1999, The Journal of Biological Chemistry.

Dual agonist occupancy of AT1-R-α2C-AR heterodimers results in atypical Gs-PKA signaling.

Céline Galés, Marie-Hélène Seguelas, J. Javitch, 2015, Nature chemical biology.

G protein stoichiometry dictates biased agonism through distinct receptor-G protein partitioning

J. Senard, C. Galés, M. Séguélas, 2017, Scientific Reports.

Analysis of Arrestin Recruitment to Chemokine Receptors by Bioluminescence Resonance Energy Transfer.

N. Heveker, C. Boularan, C. Galés, 2016, Methods in enzymology.

Cardioprotective Angiotensin-(1–7) Peptide Acts as a Natural-Biased Ligand at the Angiotensin II Type 1 Receptor

C. Boularan, A. Pathak, J. Senard, 2016, Hypertension.

Structure of cholecystokinin receptor binding sites and mechanism of activation/inactivation by agonists/antagonists.

B. Maigret, L. Pradayrol, S. Silvente-Poirot, 2002, Pharmacology & toxicology.

Role of the ubiquitin–proteasome system in the regulation of P2Y13 receptor expression: impact on hepatic HDL uptake

L. Martinez, C. Galés, M. Laffargue, 2014, Cellular and Molecular Life Sciences.

Real-time monitoring of receptor and G-protein interactions in living cells

Michel Bouvier, Céline Galés, M. Bouvier, 2005, Nature Methods.

Functional Enhancement of AT1R Potency in the Presence of the TPαR Is Revealed by a Comprehensive 7TM Receptor Co-Expression Screen

D. Weiner, C. Lyngsø, J. L. Hansen, 2013, PloS one.

Functional Selective Oxytocin-derived Agonists Discriminate between Individual G Protein Family Subtypes*

M. Manning, M. Bouvier, C. Galés, 2011, The Journal of Biological Chemistry.

Cardiac Fibroblasts Regulate Sympathetic Nerve Sprouting and Neurocardiac Synapse Stability

A. Pathak, J. Senard, C. Galés, 2013, PloS one.

The Elastin Receptor Complex: An Emerging Therapeutic Target Against Age-Related Vascular Diseases

L. Martiny, L. Duca, H. Sartelet, 2022, Frontiers in Endocrinology.

Specific interactions between Epac1, β-arrestin2 and PDE4D5 regulate β-adrenergic receptor subtype differential effects on cardiac hypertrophic signaling.

G. Baillie, F. Lezoualc’h, C. Galés, 2013, Cellular signalling.

Coexpression of CCR7 and CXCR4 During B Cell Development Controls CXCR4 Responsiveness and Bone Marrow Homing

M. Parmentier, J. Springael, C. Galés, 2019, Frontiers in immunology.

Deciphering biased inverse agonism of cangrelor and ticagrelor at P2Y12 receptor

B. Payrastre, L. Martinez, J. Senard, 2018, Cellular and Molecular Life Sciences.

α2B-Adrenergic receptors activate MAPK and modulate proliferation of primary cultured proximal tubule cells

C. Flordellis, C. Galés, C. Denis, 2002 .

2 B-Adrenergic receptors activate MAPK and modulate proliferation of primary cultured proximal tubule cells

C. Flordellis, C. Galés, C. Denis, 2002 .

Differential β2-adrenergic receptor expression defines the phenotype of non-tumorigenic and malignant human breast cell lines

S. Copsel, A. Bruzzone, C. Davio, 2014, Oncotarget.

Nanoscale structural mapping as a measure of maturation in the murine frontal cortex

J. Senard, C. Galés, D. Arvanitis, 2017, Brain Structure and Function.

Mutation of Asn-391 within the Conserved NPXXY Motif of the Cholecystokinin B Receptor Abolishes Gq Protein Activation without Affecting Its Association with the Receptor*

A. Kowalski-Chauvel, L. Pradayrol, N. Vaysse, 2000, The Journal of Biological Chemistry.

Characterization of humoral immune responses induced by immunization with plasmid DNA expressing HIV-1 Nef accessory protein.

L. Montagnier, C. Galés, E. Bahraoui, 1998, Vaccine.

Glycosylation-Dependent IFN-γR Partitioning in Lipid and Actin Nanodomains Is Critical for JAK Activation

J. Casanova, N. Bertaux, D. Marguet, 2016, Cell.

Atomic force and electron microscopic-based study of sarcolemmal surface of living cardiomyocytes unveils unexpected mitochondrial shift in heart failure.

L. Chopinet, D. Alsteens, B. Payre, 2014, Journal of molecular and cellular cardiology.

Inverse agonist efficacy of selatogrel blunts constitutive P2Y12 receptor signaling by inducing the inactive receptor conformation.

C. Galés, A. Mac Sweeney, M. Riederer, 2022, Biochemical pharmacology.

Coexpression of CCR7 and CXCR4 During B Cell Development Controls CXCR4 Responsiveness and Bone Marrow Homing

M. Parmentier, J. Springael, C. Galés, 2019, bioRxiv.

Biased Signaling at Chemokine Receptors*

M. Parmentier, J. Springael, C. Galés, 2015, The Journal of Biological Chemistry.

Agonism, Antagonism, and Inverse Agonism Bias at the Ghrelin Receptor Signaling*

Jean Martinez, J. Fehrentz, S. Denoyelle, 2015, The Journal of Biological Chemistry.

Homologous regulation of the α2C‐adrenoceptor subtype in human hepatocarcinoma, HepG2

C. Galés, S. Schaak, C. Cayla, 1999, British journal of pharmacology.

High tumorigenic potential of a constitutively active mutant of the cholecystokinin 2 receptor

L. Pradayrol, L. Buscail, M. Poirot, 2003, Oncogene.

Increased Capillary Permeability in Heart Induces Diastolic Dysfunction Independently of Inflammation, Fibrosis, or Cardiomyocyte Dysfunction

T. Couffinhal, C. Duplàa, M. Renault, 2022, Arteriosclerosis, thrombosis, and vascular biology.

Ephrin-B1 regulates the adult diastolic function through a late postnatal maturation of cardiomyocyte surface crests

T. Couffinhal, T. Sulpice, J. Senard, 2023, eLife.

The experimental power of FR900359 to study Gq-regulated biological processes

H. Dohlman, C. Müller, M. Hesse, 2015, Nature Communications.

Signaling Properties of Chemerin Receptors CMKLR1, GPR1 and CCRL2

M. Parmentier, J. Springael, C. Galés, 2016, PloS one.

Glycoprotein hormone receptors: link between receptor homodimerization and negative cooperativity

S. Swillens, S. Costagliola, M. Bouvier, 2005, The EMBO journal.

GHSR-D2R heteromerization modulates dopamine signaling through an effect on G protein conformation

H. Hamm, G. Ferry, J. Boutin, 2018, Proceedings of the National Academy of Sciences.

Molecular organization and dynamics of the melatonin MT1 receptor/RGS20/Gi protein complex reveal asymmetry of receptor dimers for RGS and Gi coupling

F. Zamponi, P. Delagrange, R. Jockers, 2010, The EMBO journal.

Dosage‐dependent regulation of cell proliferation and adhesion through dual β2‐adrenergic receptor/cAMP signals

A. Bruzzone, J. Senard, C. Galés, 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Conformational Rearrangements and Signaling Cascades Involved in Ligand-Biased Mitogen-Activated Protein Kinase Signaling through the β1-Adrenergic Receptor

M. Bouvier, C. Galés, K. Ogawa, 2008, Molecular Pharmacology.

Cholesterol-dependent separation of the beta2-adrenergic receptor from its partners determines signaling efficacy: insight into nanoscale organization of signal transduction.

Michel Bouvier, Céline Galés, Yann Percherancier, 2008, The Journal of biological chemistry.

G protein stoichiometry dictates biased agonism through distinct receptor-G protein partitioning

J. Senard, C. Galés, S. Pontier, 2017, Scientific Reports.

Tetrafluorinated versus hydrogenated azobenzene polymers in water: access to visible-light stimulus at the expense of responsiveness

J. Putaux, E. Nicol, C. Galés, 2023, Journal of Photochemistry and Photobiology A: Chemistry.

Structural evidence for a new elaborate 3D-organization of the cardiomyocyte lateral membrane in adult mammalian cardiac tissues

B. Payre, A. Pathak, J. Senard, 2018, Cardiovascular research.

Cardiac cAMP: production, hydrolysis, modulation and detection

C. Boularan, C. Galés, 2015, Front. Pharmacol..

Specific roles of Gi protein family members revealed by dissecting SST5 coupling in human pituitary cells

P. Beck‐Peccoz, C. Galés, B. Chini, 2013, Journal of Cell Science.

Exercise training-induced modification in autonomic nervous system: An update for cardiac patients.

T. Guiraud, M. Labrunée, A. Pathak, 2017, Annals of physical and rehabilitation medicine.

Short-term effects of a 3-week interval training program on heart rate variability in chronic heart failure. A randomised controlled trial.

T. Guiraud, M. Labrunée, A. Pathak, 2019, Annals of physical and rehabilitation medicine.

Identification of a novel snake peptide toxin displaying high affinity and antagonist behaviour for the α2‐adrenoceptors

E. De Pauw, G. Mourier, D. Servent, 2010, British journal of pharmacology.

High-intensity interval exercise improves vagal tone and decreases arrhythmias in chronic heart failure.

L. Bosquet, T. Guiraud, M. Labrunée, 2013, Medicine and science in sports and exercise.

G protein-coupled receptors, an unexploited animal toxin targets: Exploration of green mamba venom for novel drug candidates active against adrenoceptors.

G. Mourier, D. Servent, J. Senard, 2012, Toxicon : official journal of the International Society on Toxinology.

Deciphering biased inverse agonism of cangrelor and ticagrelor at P2Y12 receptor

B. Payrastre, L. Martinez, J. Senard, 2018, Cellular and Molecular Life Sciences.

Atomic Force Microscopy: an innovative technology to explore cardiomyocyte cell surface in cardiac physio/pathophysiology

Céline Guilbeau-Frugier, Véronique Lachaize, Cécile Formosa-Dague, 2015 .

Crest maturation at the cardiomyocyte surface contributes to a new late postnatal development stage that controls the diastolic function of the adult heart

T. Couffinhal, T. Sulpice, J. Senard, 2022, bioRxiv.

Evaluation of upconverting nanoparticles towards heart theranostics

C. Roux, J. Senard, C. Galés, 2019, bioRxiv.

An Essential Role for RGS Protein/Gαi2 Interactions in B Lymphocyte–Directed Cell Migration and Trafficking

C. Boularan, C. Galés, J. Kehrl, 2015, The Journal of Immunology.

Ephrin-B1 blocks adult cardiomyocyte proliferation and heart regeneration

A. Prats, B. Ducommun, A. Pathak, 2019, bioRxiv.

Partial Agonist and Biased Signaling Properties of the Synthetic Enantiomers J113863/UCB35625 at Chemokine Receptors CCR2 and CCR5*

M. Parmentier, J. Springael, C. Galés, 2016, The Journal of Biological Chemistry.

Probing heterotrimeric G protein activation: applications to biased ligands.

J. Senard, C. Galés, C. Denis, 2012, Current pharmaceutical design.

Role of the ubiquitin–proteasome system in the regulation of P2Y13 receptor expression: impact on hepatic HDL uptake

L. Martinez, C. Galés, M. Laffargue, 2014, Cellular and Molecular Life Sciences.

Autonomic Nervous System Adaptation and Circadian Rhythm Disturbances of the Cardiovascular System in a Ground-Based Murine Model of Spaceflight

S. Déjean, C. Galés, D. Arvanitis, 2023, Life.

Bioluminescence Resonance Energy Transfer Assays Reveal Ligand-specific Conformational Changes within Preformed Signaling Complexes Containing δ-Opioid Receptors and Heterotrimeric G Proteins*

M. Bouvier, G. Piñeyro, N. Audet, 2008, Journal of Biological Chemistry.

Deciphering biased-agonism complexity reveals a new active AT1 receptor entity.

J. L. Hansen, A. Pathak, J. Senard, 2012, Nature chemical biology.

A cell-permeable inhibitor to trap Gαq proteins in the empty pocket conformation.

U. Holzgrabe, B. Fleischmann, M. Gütschow, 2014, Chemistry & biology.

proliferation of primary cultured proximal tubule cells -Adrenergic receptors activate MAPK and modulate

C. Flordellis, C. Galés, C. Denis, 2016 .

Ephrin-B1 Is a Novel Specific Component of the Lateral Membrane of the Cardiomyocyte and Is Essential for the Stability of Cardiac Tissue Architecture Cohesion

F. Despas, B. Payre, A. Pathak, 2012, Circulation research.

Detecting and imaging protein-protein interactions during G protein-mediated signal transduction in vivo and In situ by using fluorescence-based techniques

T. Hébert, C. Galés, R. V. Rebois, 2006, Cell Biochemistry and Biophysics.

Delineating biased ligand efficacy at 7TM receptors from an experimental perspective.

J. Senard, C. Galés, Ségolène Galandrin, 2016, The international journal of biochemistry & cell biology.

Biophysical properties of cardiomyocyte surface explored by multiparametric AFM.

J. Senard, C. Galés, C. Guilbeau-Frugier, 2017, Journal of structural biology.

Ghrelin receptor conformational dynamics regulate the transition from a preassembled to an active receptor:Gq complex

D. Pérahia, E. Trinquet, B. Mouillac, 2015, Proceedings of the National Academy of Sciences.

Probing the activation-promoted structural rearrangements in preassembled receptor–G protein complexes

Michel Bouvier, Céline Galés, Yann Percherancier, 2006, Nature Structural &Molecular Biology.

Full and Partial Agonists of Thromboxane Prostanoid Receptor Unveil Fine Tuning of Receptor Superactive Conformation and G Protein Activation

C. Galés, B. Chini, M. Busnelli, 2013, PloS one.

Heterotrimeric G proteins form stable complexes with adenylyl cyclase and Kir3.1 channels in living cells

M. Robitaille, M. Bouvier, T. Hébert, 2006, Journal of Cell Science.

Immunohistologic Features of Cerebral Venous Thrombosis Due to Vaccine-Induced Immune Thrombotic Thrombocytopenia

J. Albucher, J. Olivot, F. Roux, 2023, Neurology: Neuroimmunology & Neuroinflammation.

Platelet P2Y1 receptor exhibits constitutive G protein signaling and β-arrestin 2 recruitment

E. Kostenis, B. Payrastre, L. Martinez, 2023, BMC Biology.

Atomic force microscopy-single-molecule force spectroscopy unveils GPCR cell surface architecture

J. Azaïs, J. Senard, C. Galés, 2022, Communications Biology.

Atomic force microscopy-single-molecule force spectroscopy unveils GPCR cell surface architecture

J. Azaïs, J. Senard, C. Galés, 2022, Communications Biology.

Mapping HA‐tagged protein at the surface of living cells by atomic force microscopy

M. Rols, C. Galés, E. Dague, 2015, Journal of molecular recognition : JMR.

Mutation of Asn-391 within the conserved NPXXY motif of the cholecystokinin B receptor abolishes Gq protein activation without affecting its association with the receptor.

A. Kowalski-Chauvel, L. Pradayrol, N. Vaysse, 2000, The Journal of biological chemistry.

Poster session 2

Hugo A. Katus, V. V. Miroshnikova, Paolo Dario, 2004, EP Europace.

Cerebrovascular and cardiovascular autonomic regulation in sickle cell patients with white matter lesions

F. Bonneville, J. Senard, C. Galés, 2023, medRxiv.

Cholesterol-dependent Separation of the β2-Adrenergic Receptor from Its Partners Determines Signaling Efficacy

Y. Percherancier, M. Bouvier, C. Galés, 2008, Journal of Biological Chemistry.