C. Le May

发表

Involvement of ZIP/p62 in the regulation of PPARalpha transcriptional activity by p38-MAPK.

M. Caüzac, J. Girard, Claire Diradourian, 2008, Biochimica et biophysica acta.

The Tryptophan/Kynurenine Pathway: A Novel Cross-Talk between Nutritional Obesity, Bariatric Surgery and Taste of Fat

J. Pais de Barros, S. Ledoux, P. Besnard, 2021, Nutrients.

PCSK9 Dominant Negative Mutant Results in Increased LDL Catabolic Rate and Familial Hypobetalipoproteinemia

M. Krempf, R. Guérois, C. Langhi, 2009, Arteriosclerosis, thrombosis, and vascular biology.

Activation of the farnesoid X receptor represses PCSK9 expression in human hepatocytes

M. Krempf, C. Langhi, B. Staels, 2008, FEBS letters.

The Sodium–Glucose Cotransporter 2 Inhibitor Dapagliflozin Prevents Cardiomyopathy in a Diabetic Lipodystrophic Mouse Model

F. Charpentier, X. Prieur, B. Staels, 2017, Diabetes.

Reduced hepatic fatty acid oxidation in fasting PPARα null mice is due to impaired mitochondrial hydroxymethylglutaryl‐CoA synthase gene expression

T. Pineau, J. Girard, C. Le May, 2000, FEBS letters.

VLDL (Very-Low-Density Lipoprotein)-Apo E (Apolipoprotein E) May Influence Lp(a) (Lipoprotein [a]) Synthesis or Assembly

M. Krempf, S. Hadjadj, L. Flet, 2020, Arteriosclerosis, thrombosis, and vascular biology.

Orosensory Perception of Fat/Sweet Stimuli and Appetite-Regulating Peptides before and after Sleeve Gastrectomy or Gastric Bypass in Adult Women with Obesity

M. Coupaye, S. Ledoux, P. Besnard, 2021, Nutrients.

Effects of proprotein convertase subtilisin kexin type 9 modulation in human pancreatic beta cells function.

F. Pattou, V. Gmyr, C. Le May, 2021, Atherosclerosis.

Circulating PCSK9 levels are not associated with the conversion to type 2 diabetes.

I. Benseñor, P. Lotufo, R. Santos, 2019, Atherosclerosis.

Nutritional biomarkers and heart failure requiring hospitalization in patients with type 2 diabetes: the SURDIAGENE cohort

V. Rigalleau, S. Hadjadj, S. Ragot, 2022, Cardiovascular Diabetology.

Plasma PCSK9 concentrations during the course of nondiabetic chronic kidney disease: Relationship with glomerular filtration rate and lipid metabolism.

C. Le May, J. Cristol, B. Cariou, 2017, Journal of clinical lipidology.

Control of gene expression by fatty acids.

J. Girard, C. Le May, J. Pégorier, 2004, The Journal of nutrition.

Plasma apolipoprotein concentrations and incident diabetes in subjects with prediabetes

S. Hadjadj, C. Le May, B. Cariou, 2022, Cardiovascular Diabetology.

PAX4 gene variations predispose to ketosis-prone diabetes.

S. Leal, M. Molokhia, M. German, 2004, Human molecular genetics.

PCSK9 regulates the NODAL signaling pathway and cellular proliferation in hiPSCs

A. Prat, X. Prieur, C. Le May, 2021, Stem cell reports.

Seipin deficiency alters brown adipose tissue thermogenesis and insulin sensitivity in a non-cell autonomous mode

X. Prieur, C. Pecqueur, C. Le May, 2016, Scientific Reports.

Effect of Parathyroidectomy on Metabolic Homeostasis in Primary Hyperparathyroidism

C. Le May, B. Cariou, M. Croyal, 2022, Journal of clinical medicine.

Role of PCSK9 beyond liver involvement

C. Le May, B. Cariou, K. Si-Tayeb, 2015, Current opinion in lipidology.

Association between plasma PCSK9 and gamma-glutamyl transferase levels in diabetic patients.

M. Krempf, C. Langhi, C. Le May, 2010, Atherosclerosis.

Circulating Rather Than Intestinal PCSK9 (Proprotein Convertase Subtilisin Kexin Type 9) Regulates Postprandial Lipemia in Mice

A. Prat, N. Seidah, X. Prieur, 2020, Arteriosclerosis, thrombosis, and vascular biology.

Dual Mechanisms for the Fibrate-mediated Repression of Proprotein Convertase Subtilisin/Kexin Type 9*

M. Krempf, C. Langhi, P. Nguyen, 2008, Journal of Biological Chemistry.

Urine-sample-derived human induced pluripotent stem cells as a model to study PCSK9-mediated autosomal dominant hypercholesterolemia

C. Le May, K. Zibara, B. Cariou, 2014, Disease Models & Mechanisms.

PCSK9-deficiency does not alter blood pressure and sodium balance in mouse models of hypertension.

X. Prieur, C. Le May, J. Hadchouel, 2014, Atherosclerosis.

Transintestinal Cholesterol Excretion Is an Active Metabolic Process Modulated by PCSK9 and Statin Involving ABCB1

B. Pillot, X. Prieur, C. Le May, 2013, Arteriosclerosis, thrombosis, and vascular biology.

Glycaemic control influences the relationship between plasma PCSK9 and LDL cholesterol in type 1 diabetes

S. Hadjadj, B. Vergès, P. Saulnier, 2017, Diabetes, obesity & metabolism.

PCSK9 is not secreted from mature differentiated intestinal cells

A. Prat, N. Seidah, X. Prieur, 2021, Journal of lipid research.

Proprotein Convertase Subtilisin Kexin Type 9 Null Mice Are Protected From Postprandial Triglyceridemia

M. Krempf, C. Langhi, A. Jarry, 2009, Arteriosclerosis, thrombosis, and vascular biology.

Letter from Le May and Cariou regarding article, "Proprotein convertase subtilisin kexin type 9 promotes intestinal overproduction of triglyceride-rich apolipoprotein B lipoproteins through both low-density lipoprotein receptor-dependent and -independent mechanisms".

C. Le May, B. Cariou, 2015, Circulation.

Circulating PCSK9 levels are not associated with the severity of hepatic steatosis and NASH in a high-risk population.

L. V. Van Gaal, B. Vergès, B. Staels, 2018, Atherosclerosis.

Importance of Extranuclear Estrogen Receptor-α and Membrane G Protein–Coupled Estrogen Receptor in Pancreatic Islet Survival

K. Korach, D. Clegg, Suhuan Liu, 2009, Diabetes.

Generation of a GPR146 knockout human induced pluripotent stem cell line (ITXi001-A-1).

C. Le May, B. Cariou, A. Caillaud, 2022, Stem cell research.

Preserved adrenal function in fully PCSK9-deficient subject.

C. Le May, I. Benoit, B. Cariou, 2014, International journal of cardiology.

One-year metreleptin therapy decreases PCSK9 serum levels in diabetic patients with monogenic lipodystrophy syndromes.

C. Vigouroux, X. Prieur, J. Gautier, 2017, Diabetes & Metabolism.

Routine use of statins and increased COVID-19 related mortality in inpatients with type 2 diabetes: Results from the CORONADO study

S. Hadjadj, P. Gourdy, P. Moulin, 2020, Diabetes & Metabolism.

PCSK9 deficiency results in a specific shedding of excess LDLR in female mice only: Role of hepatic cholesterol.

A. Prat, M. Koschinsky, A. Chamberland, 2022, Biochimica et biophysica acta. Molecular and cell biology of lipids.

Extranuclear estrogen receptor-α stimulates NeuroD1 binding to the insulin promoter and favors insulin synthesis

B. Katzenellenbogen, J. Katzenellenbogen, K. Korach, 2010, Proceedings of the National Academy of Sciences.

Identification of a Gain-of-Function LIPC Variant as a Novel Cause of Familial Combined Hypocholesterolemia

Enriqueta Clemente García, J. Pais de Barros, L. Duvillard, 2022, Circulation.

The Role of Estrogens in Pancreatic Islet Physiopathology.

Suhuan Liu, C. Le May, Jun Ho Kim, 2017, Advances in experimental medicine and biology.

Bile acids associate with glucose metabolism, but do not predict conversion from impaired fasting glucose to diabetes.

S. Hadjadj, B. Staels, A. Descat, 2019, Metabolism: clinical and experimental.

Sleeve Gastrectomy Alters Intestinal Permeability in Diet-Induced Obese Mice

J. Pais de Barros, M. Neunlist, C. Le May, 2017, Obesity Surgery.

In vivo evidence for transintestinal cholesterol efflux in patients with complete common bile duct obstruction.

M. Krempf, X. Prieur, L. Flet, 2019, Journal of clinical lipidology.

Regulation of liver carnitine palmitoyltransferase I gene expression by hormones and fatty acids.

G. Asins, J. Girard, C. Le May, 2001, Biochemical Society transactions.

FACS-assisted CRISPR-Cas9 genome editing of human induced pluripotent stem cells

J. Barc, C. Le May, B. Cariou, 2022, STAR protocols.

The complex ABCG5/ABCG8 Regulates Vitamin D Absorption Rate and Contributes to its Efflux from the Intestine.

C. Defoort, C. Le May, Marielle Margier, 2021, Molecular nutrition & food research.

P-glycoprotein (ABCB1) is involved in vitamin K efflux.

C. Le May, Marielle Margier, E. Reboul, 2020, Food chemistry.

Plasma cholesterol is excreted in the feces of patients with complete common bile duct obstruction : In vivo evidence for TICE pathway in humans.

M. Krempf, X. Prieur, L. Flet, 2017, Atherosclerosis.

Circulating PCSK9 levels in acute coronary syndrome: Results from the PC-SCA-9 prospective study.

V. Probst, V. Letocart, C. Le May, 2017, Diabetes & metabolism.

Unexpected metabolic disorders induced by endocrine disruptors in Xenopus tropicalis provide new lead for understanding amphibian decline

S. Reynaud, C. Le May, A. Bulteau, 2018, Proceedings of the National Academy of Sciences.

E2F1 inhibits circulating cholesterol clearance by regulating Pcsk9 expression in the liver.

L. Fajas, Pierre-Damien Denechaud, C. Le May, 2017, JCI insight.

A high-throughput mass spectrometry-based assay for large-scale profiling of circulating human apolipoproteins[S]

M. Krempf, S. Hadjadj, C. Le May, 2020, Journal of Lipid Research.

Fatty acids induce L-CPT I gene expression through a PPARalpha-independent mechanism in rat hepatoma cells.

M. Caüzac, J. Girard, Claire Diradourian, 2005, The Journal of nutrition.

Estrogen receptor activation reduces lipid synthesis in pancreatic islets and prevents β cell failure in rodent models of type 2 diabetes.

M. Prentki, K. Korach, Suhuan Liu, 2011, The Journal of clinical investigation.

Retrograde cholesterol transport in the human Caco-2/TC7 cell line: a model to study trans-intestinal cholesterol excretion in atherogenic and diabetic dyslipidemia

B. Staels, M. Schonewille, C. Le May, 2017, Acta Diabetologica.

Estrogens protect pancreatic beta-cells from apoptosis and prevent insulin-deficient diabetes mellitus in mice.

K. Korach, M. Tsai, E. Simpson, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Plasma PCSK9 concentrations during an oral fat load and after short term high-fat, high-fat high-protein and high-fructose diets

R. Kreis, C. Boesch, M. Krempf, 2013, Nutrition & Metabolism.

Seipin localizes at endoplasmic-reticulum-mitochondria contact sites to control mitochondrial calcium import and metabolism in adipocytes.

E. Ikonen, C. Vigouroux, I. Belevich, 2022, Cell reports.

Clinical aspects of PCSK9.

C. Le May, B. Cariou, Bertrand Cariou, 2011, Atherosclerosis.

PCSK9 is expressed in pancreatic delta-cells and does not alter insulin secretion.

Michel Krempf, M. Krempf, F. Pattou, 2009, Biochemical and biophysical research communications.

PCSK9 Concentrations in Cerebrospinal Fluid Are Not Specifically Increased in Alzheimer's Disease.

P. Derkinderen, C. Le May, B. Cariou, 2018, Journal of Alzheimer's disease : JAD.

Genetic Inhibition of PCSK9 and Liver Function.

C. Le May, B. Cariou, S. Smati, 2020, JAMA cardiology.

[Trans-intestinal cholesterol excretion (TICE): a new route for cholesterol excretion].

C. Le May, B. Cariou, C. Blanchard, 2014, Medecine sciences : M/S.

LDL lowering effect of PCSK9 inhibition is reduced in women

C. Le May, B. Cariou, R. Capoulade, 2023, European heart journal. Cardiovascular pharmacotherapy.

Transintestinal cholesterol excretion in health and disease

C. Le May, B. Cariou, D. Garçon, 2022, Current Atherosclerosis Reports.

Taste-Driven Responsiveness to Fat and Sweet Stimuli in Mouse Models of Bariatric Surgery

S. Ledoux, P. Besnard, C. Le May, 2022, Biomedicines.

PPARγ Modulates Long Chain Fatty Acid Processing in the Intestinal Epithelium

W. Wahli, M. Orešič, C. Le May, 2017, International journal of molecular sciences.

FGF21 Improves the Adipocyte Dysfunction Related to Seipin Deficiency

R. Gimeno, X. Prieur, C. Le May, 2016, Diabetes.

Corrigendum: PCSK9 is not secreted from mature differentiated intestinal cells.

A. Prat, X. Prieur, C. Le May, 2022, Journal of lipid research.