C. Vrettou

发表

Enhanced lung gene expression after aerosol delivery of concentrated pDNA/PEI complexes.

Christina Vrettou, Peter Tennant, Alison Baker, 2008, Molecular therapy : the journal of the American Society of Gene Therapy.

De novo interstitial duplication of the 15q11.2‐q14 PWS/AS region of maternal origin: Clinical description, array CGH analysis, and review of the literature

M. Tzetis, E. Kanavakis, S. Kitsiou-Tzeli, 2010, American journal of medical genetics. Part A.

Prenatal diagnosis of the thalassaemia syndromes by rapid DNA analytical methods.

M. Tzetis, E. Kanavakis, J. Traeger-Synodinos, 1997, Molecular human reproduction.

High throughput analysis of MHC‐I and MHC‐DR diversity of Brazilian cattle populations

C. Vrettou, W. Morrison, Deepali Vasoya, 2021, HLA.

Dramatic elevations of interleukin-6 and acute-phase reactants in athletes participating in the ultradistance foot race spartathlon: severe systemic inflammation and lipid and lipoprotein changes in protracted exercise.

I. Papassotiriou, A. Margeli, G. Chrousos, 2005, The Journal of clinical endocrinology and metabolism.

METHOD Optimising the quality and integrity of RNA samples from bronchial airway tissues

G. Mclachlan, C. Vrettou, D. Collie, 2011 .

Pregnancies following blastocyst stage transfer in PGD cycles at risk for beta-thalassaemic haemoglobinopathies.

M. Tzetis, E. Kanavakis, J. Traeger-Synodinos, 2002, Human reproduction.

Molecular Studies of β-Thalassemia Heterozygotes with Raised Hb F Levels

I. Papassotiriou, E. Kanavakis, J. Traeger-Synodinos, 2000 .

Sensitive Monogenic Noninvasive Prenatal Diagnosis by Targeted Haplotyping

E. de Bruijn, S. Pulit, G. T. te Meerman, 2017, American journal of human genetics.

Rapid Detection of Fetal Mendelian Disorders: Thalassemia and Sickle Cell Syndromes.

E. Kanavakis, J. Traeger-Synodinos, C. Vrettou, 2018, Methods in molecular biology.

Rapid detection of fetal Mendelian disorders: thalassemia and sickle cell syndromes.

E. Kanavakis, J. Traeger-Synodinos, C. Vrettou, 2008, Methods in molecular biology.

Cell-free DNA levels in acute myocardial infarction patients during hospitalization

C. Vrettou, E. Kanavakis, A. Destouni, 2009, Acta cardiologica.

Real‐time PCR for single‐cell genotyping in sickle cell and thalassemia syndromes as a rapid, accurate, reliable, and widely applicable protocol for preimplantation genetic diagnosis

M. Tzetis, E. Kanavakis, J. Traeger-Synodinos, 2004, Human mutation.

Eplerenone in the treatment of central serous chorioretinopathy: a review of the literature

C. Vrettou, I. Chatziralli, P. Theodossiadis, 2018, International Journal of Retina and Vitreous.

Molecular, haematological and clinical studies of the −101 C → T substitution of the β‐globin gene promoter in 25 β‐thalassaemia intermedia patients and 45 heterozygotes

J. Traeger-Synodinos, M. Tzetis, E. Kanavakis, 1999, British journal of haematology.

Screening non-deletion α-thalassaemia mutations in the HBA1 and HBA2 genes by high-resolution melting analysis

T. K. Christopoulos, J. Traeger-Synodinos, E. Kanavakis, 2015, Clinical chemistry and laboratory medicine.

Phenotypic and molecular diversity of haemoglobin H disease: a Greek experience

I. Papassotiriou, E. Kanavakis, J. Traeger-Synodinos, 2000, British journal of haematology.

A widely applicable strategy for single cell genotyping of β‐thalassaemia mutations using DGGE analysis: application to preimplantation genetic diagnosis

M. Tzetis, E. Kanavakis, J. Traeger-Synodinos, 1999, Prenatal diagnosis.

Preimplantation genetic diagnosis in 10 couples at risk for transmitting β‐thalassaemia major: clinical experience including the initiation of six singleton pregnancies

M. Tzetis, E. Kanavakis, J. Traeger-Synodinos, 1999, Prenatal diagnosis.

Single-cell high resolution melting analysis: A novel, generic, pre-implantation genetic diagnosis (PGD) method applied to cystic fibrosis (HRMA CF-PGD).

J. Traeger-Synodinos, M. Tzetis, S. Kitsiou-Tzeli, 2016, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

Secreted Gaussia luciferase as a sensitive reporter gene for in vivo and ex vivo studies of airway gene transfer.

M. J. Roberts, R. Scheule, Seng H. Cheng, 2011, Biomaterials.

Pre-clinical evaluation of three non-viral gene transfer agents for cystic fibrosis after aerosol delivery to the ovine lung

D. Porteous, D. Shaw, R. Scheule, 2011, Gene Therapy.

Hydrophobic mycobacterial antigens elicit polyfunctional T cells in Mycobacterium bovis immunised cattle

Thomas M. Holder, C. Vrettou, W. Morrison, 2020 .

The triplicated α‐globin gene locus in β‐thalassaemia heterozygotes: clinical, haematological, biosynthetic and molecular studies

J. Traeger-Synodinos, E. Kanavakis, J. Traeger-Synodinos, 1996 .

Genotyping of β-Globin Gene Mutations in Single Lymphocytes: A Preliminary Study for Preimplantation Genetic Diagnosis of Monogenic Disorders

J. Traeger-Synodinos, E. Kanavakis, C. Vrettou, 2012, Hemoglobin.

Pre-implantation HLA matching: The production of a Saviour Child.

J. Traeger-Synodinos, C. Vrettou, Maria Moutafi, 2017, Best practice & research. Clinical obstetrics & gynaecology.

A Generic, Flexible Protocol for Preimplantation Human Leukocyte Antigen Typing Alone or in Combination with a Monogenic Disease, for Rapid Case Work-up and Application

J. Traeger-Synodinos, E. Kanavakis, C. Vrettou, 2014, Hemoglobin.

Immunity, safety and protection of an Adenovirus 5 prime - Modified Vaccinia virus Ankara boost subunit vaccine against Mycobacterium avium subspecies paratuberculosis infection in calves

C. Vrettou, J. McNair, T. Bull, 2014, Veterinary Research.

Nature and consequences of interactions between Salmonella enterica serovar Dublin and host cells in cattle

M. Stevens, C. Vrettou, J. Hopkins, 2019, Veterinary Research.

Rare beta-thalassemia alleles in the Greek and Greek Cypriot populations.

E. Kanavakis, J. Traeger-Synodinos, C. Vrettou, 1998, Hemoglobin.

The safety profile of a cationic lipid-mediated cystic fibrosis gene transfer agent following repeated monthly aerosol administration to sheep.

D. Porteous, D. Shaw, R. Scheule, 2013, Biomaterials.

Erythroid marrow activity and functional anemia in patients with the rare interaction of a single functional a-globin and beta-globin gene.

I. Papassotiriou, E. Kanavakis, J. Traeger-Synodinos, 2001, Haematologica.

Iron Erythroid marrow activity and functional anemia in patients with the rare interaction of a single functional α-globin and β-globin gene

I. Papassotiriou, E. Kanavakis, J. Traeger-Synodinos, 2022 .

Validation of recombinant Sendai virus in a non-natural host model

T. Shu, M. Hasegawa, G. Mclachlan, 2011, Gene Therapy.

Cell-free plasma DNA as a novel marker of aseptic inflammation severity related to exercise overtraining.

A. Jamurtas, I. Papassotiriou, I. Fatouros, 2006, Clinical chemistry.

Synthetically engineered IgG1 antibody Fc fragments presenting influenza A virus receptor sialic acid inhibit viral haemagglutination activity, but enhance virus replication in cultured A549 cells

C. Vrettou, R. Pleass, P. Blundell, 2022, bioRxiv.

Novel and Known Microsatellite Markers Within the β-Globin Cluster to Support Robust Preimplantation Genetic Diagnosis of β-Thalassemia and Sickle Cell Syndromes

E. Kanavakis, J. Traeger-Synodinos, C. Vrettou, 2011, Hemoglobin.

Optimizing aerosol gene delivery and expression in the ovine lung.

D. Porteous, R. Scheule, Seng H. Cheng, 2007, Molecular therapy : the journal of the American Society of Gene Therapy.

Time of sampling is crucial for measurement of cell-free plasma DNA following acute aseptic inflammation induced by exercise.

A. Jamurtas, I. Papassotiriou, I. Fatouros, 2010, Clinical biochemistry.

Prenatal and preimplantation diagnosis of hemoglobinopathies

J. Traeger-Synodinos, C. Vrettou, G. Kakourou, 2018, International journal of laboratory hematology.

Milroy's primary congenital lymphedema in a male infant and review of the literature.

S. Kitsiou-Tzeli, P. Makrythanasis, C. Vrettou, 2010, In vivo.

Hemoglobinopathies and preimplantation diagnostics

J. Traeger-Synodinos, C. Vrettou, G. Kakourou, 2022, International journal of laboratory hematology.

Retrospective application of transposon-directed insertion-site sequencing to investigate niche-specific virulence of Salmonella Typhimurium in cattle

N. Thomson, R. Chaudhuri, M. Stevens, 2019, BMC Genomics.

Hydrophobic Mycobacterial Antigens Elicit Polyfunctional T Cells in Mycobacterium bovis Immunized Cattle: Association With Protection Against Challenge?

Thomas M. Holder, C. Vrettou, W. Morrison, 2020, Frontiers in immunology.

Conception and pregnancy outcome in a patient with 11-bp deletion of the steroidogenic acute regulatory protein gene.

C. Vrettou, A. Sertedaki, C. Dacou-voutetakis, 2009, Fertility and sterility.

PGD for X-linked and gender-dependent disorders using a robust, flexible single-tube PCR protocol.

E. Kanavakis, J. Traeger-Synodinos, C. Vrettou, 2009, Reproductive biomedicine online.

Blastocyst biopsy versus cleavage stage biopsy and blastocyst transfer for preimplantation genetic diagnosis of beta-thalassaemia: a pilot study.

A. Trounson, J. Traeger-Synodinos, E. Kanavakis, 2007, Human reproduction.

Birth of a healthy infant following trophectoderm biopsy from blastocysts for PGD of β-thalassaemia major: Case report

A. Trounson, E. Kanavakis, J. Traeger-Synodinos, 2005 .

Mutation screening in the Greek population and evaluation of NLGN3 and NLGN4X genes causal factors for autism

E. Kanavakis, C. Vrettou, C. Sofocleous, 2013, Psychiatric genetics.

Rapid screening of multiple beta-globin gene mutations by real-time PCR on the LightCycler: application to carrier screening and prenatal diagnosis of thalassemia syndromes.

Christina Vrettou, Joanne Traeger-Synodinos, M. Tzetis, 2003, Clinical chemistry.

Molecular studies of beta-thalassemia heterozygotes with raised Hb F levels.

I. Papassotiriou, E. Kanavakis, J. Traeger-Synodinos, 2000, Hemoglobin.

An alpha-thalassemic hemoglobinopathy: homozygosity for the HB Agrinio alpha 2-globin chain variant.

I. Papassotiriou, E. Kanavakis, J. Traeger-Synodinos, 1998, Hemoglobin.

Interaction of an α+-Thalassemia Deletion with Either a Highly Unstable α-Globin Variant (α2, Codon 59, GGC→GAC) or a Nondeletional α-Thalassemia Mutation (AATAA→AATAAG): Comparison of Phenotypes Illustrating “Dominant” α-Thalassemia

I. Papassotiriou, J. Traeger-Synodinos, E. Kanavakis, 1999 .

A Rare 33 bp In‐Frame Deletion (α63–74 or α64–74 or α65–75) in the α1‐Globin Gene Causing α+‐Thalassemia: A Second Observation

I. Papassotiriou, E. Kanavakis, J. Traeger-Synodinos, 2004 .

Hb SITIA [β128(H6)Ala→Val]: AN UNSTABLE VARIANT WITH A SUBSTITUTION IN THE α1β1 INTERFACE

I. Papassotiriou, E. Kanavakis, M. Marden, 2001 .

Distinct Phenotypic Expression Associated with a New Hyperunstable Alpha Globin Variant (Hb Heraklion, α1cd37(C2)Pro>0): Comparison to Other α-Thalassemic Hemoglobinopathies

I. Papassotiriou, E. Kanavakis, J. Traeger-Synodinos, 2000 .

Noninvasive prenatal diagnosis of β‐thalassaemia using individual fetal erythroblasts isolated from maternal blood after enrichment

R. Burgemeister, J. Traeger-Synodinos, E. Kanavakis, 2007 .

Prenatal, noninvasive and preimplantation genetic diagnosis of inherited disorders: hemoglobinopathies

E. Kanavakis, J. Traeger-Synodinos, C. Vrettou, 2011, Expert review of molecular diagnostics.

A new gene associated with a beta-thalassemia phenotype: the observation of variants in SUPT5H.

F. Baas, C. Ruivenkamp, J. Traeger-Synodinos, 2020, Blood.

Microsatellite Markers Within the α-Globin Gene Cluster for Robust Preimplantation Genetic Diagnosis of Severe α-Thalassemia Syndromes in Mediterranean Populations

J. Traeger-Synodinos, E. Kanavakis, C. Vrettou, 2012, Hemoglobin.

Identification and Phenotype of MAIT Cells in Cattle and Their Response to Bacterial Infections

P. Klenerman, S. Jayaraman, D. Fairlie, 2020, bioRxiv.

Interaction of an alpha(+)-thalassemia deletion with either a highly unstable alpha-globin variant (alpha2, codon 59, GGC-->GAC) or a nondeletional alpha-thalassemia mutation (AATAAA-->AATAAG): comparison of phenotypes illustrating "dominant" alpha-thalassemia.

I. Papassotiriou, J. Traeger-Synodinos, E. Kanavakis, 1999, Hemoglobin.

Complex preimplantation genetic diagnosis for beta-thalassaemia, sideroblastic anaemia, and human leukocyte antigen (HLA)-typing

E. Kanavakis, J. Traeger-Synodinos, C. Vrettou, 2016, Systems biology in reproductive medicine.

The triplicated alpha-globin gene locus in beta-thalassaemia heterozygotes: clinical, haematological, biosynthetic and molecular studies.

E. Kanavakis, J. Traeger-Synodinos, C. Vrettou, 1996, British journal of haematology.

Immunopeptidomic Analysis of BoLA-I and BoLA-DR Presented Peptides from Theileria parva Infected Cells

M. Nielsen, S. Buus, C. Vrettou, 2022, Vaccines.

Identification and annotation of bovine granzyme genes reveals a novel granzyme encoded within the trypsin-like locus

Jie Yang, C. Vrettou, W. Morrison, 2018, Immunogenetics.

Nevoid basal carcinoma syndrome (Gorlin syndrome) and pronounced androgenic alopecia in a woman with a novel mutation p.Leu1159fsx32 in the PTCH gene

S. Kitsiou‐Tzeli, E. Kanavakis, C. Vrettou, 2011, The Journal of dermatology.

Development of a novel microarray methodology for the study of SNPs in the promoter region of the TNF-alpha gene: their association with obstructive pulmonary disease in Greek patients.

C. Roussos, M. Tzetis, E. Kanavakis, 2007, Clinical biochemistry.

An evaluation of PGD in clinical genetic services through 3 years application for prevention of beta-thalassaemia major and sickle cell thalassaemia.

M. Tzetis, E. Kanavakis, J. Traeger-Synodinos, 2003, Molecular human reproduction.

A multiplex PCR for non-invasive fetal RHD genotyping using cell-free fetal DNA.

G. Tsangaris, E. Kanavakis, C. Vrettou, 2011, In vivo.

An Update on Non-invasive Approaches for Genetic Testing of the Preimplantation Embryo

J. Traeger-Synodinos, C. Vrettou, G. Kakourou, 2022, Current genomics.

Early non-invasive detection of fetal Y chromosome sequences in maternal plasma using multiplex PCR.

E. Kanavakis, C. Vrettou, A. Antsaklis, 2012, European journal of obstetrics, gynecology, and reproductive biology.

The interaction of α° thalassaemia with Hb Icaria: three unusual cases of haemoglobinopathy H

E. Kanavakis, J. Traeger-Synodinos, C. Vrettou, 1996 .

Birth of a healthy infant following trophectoderm biopsy from blastocysts for PGD of beta-thalassaemia major.

A. Trounson, E. Kanavakis, J. Traeger-Synodinos, 2005, Human Reproduction.

High throughput analysis of MHC class I and class II diversity of Zambian indigenous cattle populations

M. Watson, G. Mainda, C. Vrettou, 2023, HLA.

Heterozygosity of the Complex Corfu δ0β+ Thalassemic Allele (HBD Deletion and HBB:c.92+5G>A) Revisited

J. Traeger-Synodinos, C. Vrettou, C. Sofocleous, 2022, Biology.

Adult‐onset beta‐thalassaemia intermedia caused by a 5‐Mb somatic clonal segmental deletion in haemopoietic stem cells involving the β‐globin locus

C. Ruivenkamp, E. Kanavakis, J. Traeger-Synodinos, 2019, British journal of haematology.

Contributing to the on-going debate around the clinical application of preimplantation embryo selection based on polygenic risk scores (PGT-P).

J. Traeger-Synodinos, P. Makrythanasis, C. Vrettou, 2023, European journal of human genetics : EJHG.

Multiplex sequence variation detection throughout the CFTR gene appropriate for preimplantation genetic diagnosis in populations with heterogeneity of cystic fibrosis mutations.

M. Tzetis, E. Kanavakis, J. Traeger-Synodinos, 2002, Molecular human reproduction.

PGD for glycogen storage disease type IV: Birth of healthy twins following successful clinical application of a mutation‐specific protocol

E. Kanavakis, J. Traeger-Synodinos, C. Vrettou, 2010, Prenatal diagnosis.

Identification and Phenotype of MAIT Cells in Cattle and Their Response to Bacterial Infections

P. Klenerman, S. Jayaraman, D. Fairlie, 2021, Frontiers in Immunology.

The interaction of alpha zero thalassaemia with Hb Icaria: three unusual cases of haemoglobinopathy H.

E. Kanavakis, J. Traeger-Synodinos, C. Vrettou, 1996, British Journal of Haematology.

The safety profile of a cationic lipid-mediated cystic fibrosis gene transfer agent following repeated monthly aerosol administration to sheep.

R. Scheule, J. Davies, S. Hyde, 2013, Biomaterials.

Retrospective application of transposon-directed insertion-site sequencing to investigate niche-specific virulence of Salmonella Typhimurium in cattle

N. Thomson, R. Chaudhuri, M. Stevens, 2019, BMC Genomics.

Impact of α-Globin Gene Expression and α-Globin Modifiers on the Phenotype of β-Thalassemia and Other Hemoglobinopathies: Implications for Patient Management

A. Finotti, C. Vrettou, C. Sofocleous, 2024, International journal of molecular sciences.

Hb Souli, a 6 bp In-Frame Deletion on the HBA2 Gene (HBA2: c.[41-46delCCTGGG]) Leads to α-Thalassemia Intermedia, When in Trans to a Single α-Globin Gene Deletion

I. Papassotiriou, J. Traeger-Synodinos, E. Kanavakis, 2015, Hemoglobin.