D. Bloom

发表

Transfection of tyrosine kinase deleted FGF receptor-1 into rat brain substantia nigra reduces the number of tyrosine hydroxylase expressing neurons and decreases concentration levels of striatal dopamine.

Indrajit Roy, Timothy Buckley, E. Stachowiak, 2005, Brain research. Molecular brain research.

Assessment of viral and non-viral gene transfer into adult rat brains using HSV-1, calcium phosphate and PEI-based methods.

E. Stachowiak, M. Stachowiak, I. Roy, 2005, Folia morphologica.

HSV Gene Expression during Latent Infection and Reactivation

D. Bloom, E. Wagner, 2002 .

Herpes Simplex Viruses Whose Replication Can Be Deliberately Controlled as Candidate Vaccines

N. Vilaboa, D. Bloom, R. Voellmy, 2020, Vaccines.

Herpes simplex virus type 1 DNA replication and gene expression during explant-induced reactivation of latently infected murine sensory ganglia

D. Bloom, E. Wagner, J. G. Stevens, 1994, Journal of virology.

A 348-base-pair region in the latency-associated transcript facilitates herpes simplex virus type 1 reactivation

D. Bloom, E. Wagner, J. M. Hill, 1996, Journal of virology.

Lund Human Mesencephalic (LUHMES) Neuronal Cell Line Supports Herpes Simplex Virus 1 Latency In Vitro

D. Bloom, T. Edwards, 2019, Journal of Virology.

Deletion of the CTRL2 Insulator in HSV-1 Results in the Decreased Expression of Genes Involved in Axonal Transport and Attenuates Reactivation In Vivo

D. Bloom, D. Neumann, Pankaj Singh, 2022, Viruses.

Antiviral Activity of 1,4-Disubstituted-1,2,3-Triazoles against HSV-1 in vitro

D. Bloom, P. Abreu, C. Buarque, 2020, Antiviral therapy.

HSV-1-mediated NGF delivery delays nociceptive deficits in a genetic model of diabetic neuropathy

I. Spigelman, N. Maidment, D. Bloom, 2006, Experimental Neurology.

Virtual screening identified compounds that bind to cyclin dependent kinase 2 and prevent herpes simplex virus type 1 replication and reactivation in neurons.

D. Bloom, T. Edwards, P. Abreu, 2019, Antiviral research.

Reliable Detection of Herpes Simplex Virus Sequence Variation by High-Throughput Resequencing

L. McIntyre, A. Morse, D. Bloom, 2017, Viruses.

Signaling Pathway Reporter Screen with SARS-CoV-2 Proteins Identifies nsp5 as a Repressor of p53 Activity

Abhishek Kumar, Abhishek Kumar, D. Bloom, 2022, Viruses.

R430: A potent inhibitor of DNA and RNA viruses

R. Yolken, R. Ptak, A. Chattopadhyay, 2018, Scientific Reports.

A 77 Amino Acid Region in the N-Terminal Half of the HSV-1 E3 Ubiquitin Ligase ICP0 Contributes to Counteracting an Established Type 1 Interferon Response

D. Bloom, Adit Dhummakupt, D. Davido, 2022, Microbiology spectrum.

Replication-Competent Controlled Herpes Simplex Virus

N. Vilaboa, D. Bloom, R. Voellmy, 2015, Journal of Virology.

Immunization by Replication-Competent, Controlled Viral Pathogen – A Novel Approach Worth Exploring for Diseases Refractory to Effective Conventional Vaccination?

N. Vilaboa, D. Bloom, R. Voellmy, 2015 .

The region of the HSV-1 latency-associated transcript required for epinephrine-induced reactivation in the rabbit does not include the 2.0-kb intron.

R. Jarman, D. Bloom, J. Loutsch, 2002, Virology.

Herpes simplex virus genome replication and transcription during induced reactivation in the rabbit eye

D. Bloom, E. Wagner, G. Devi-Rao, 1997, Journal of virology.

Individual and Synergistic Anti-Coronavirus Activities of SOCS1/3 Antagonist and Interferon α1 Peptides

D. Bloom, A. Lewin, C. M. Ahmed, 2022, Frontiers in Immunology.

Deletion of Herpes Simplex Virus 1 MicroRNAs miR-H1 and miR-H6 Impairs Reactivation

D. Bloom, D. Neumann, A. Arvin, 2020, Journal of Virology.

RANAVIRUS INFECTION OF FREE-RANGING AND CAPTIVE BOX TURTLES AND TORTOISES IN THE UNITED STATES

D. Bloom, J. Brooks, E. Jacobson, 2008, Journal of wildlife diseases.

Herpes simplex virus-1 and varicella-zoster virus latency in ganglia

R. Cohrs, D. Gilden, D. Bloom, 2003, Journal of NeuroVirology.

Different tropism of adenoviruses and adeno-associated viruses to corneal cells: implications for corneal gene therapy

W. Hauswirth, A. Ljubimov, D. Bloom, 2008, Molecular vision.

Adeno-associated Virus Vectors Efficiently Transduce Mouse and Rabbit Sensory Neurons Coinfected with Herpes Simplex Virus 1 following Peripheral Inoculation

D. Bloom, M. Ertel, A. Lewin, 2016, Journal of Virology.

Inhibition of H3K27me3-Specific Histone Demethylases JMJD3 and UTX Blocks Reactivation of Herpes Simplex Virus 1 in Trigeminal Ganglion Neurons

D. Bloom, Adit Dhummakupt, Harald Messer, 2014, Journal of Virology.

The TATGARAT Box of the HSV-1 ICP27 Gene is Essential for Immediate Early Expression but not Critical for Efficient Replication in vitro or in vivo

M. Rice, D. Bloom, R. Sandri-Goldin, 2004, Virus Genes.

Immediate-Early Expression of the Herpes Simplex Virus Type 1 ICP27 Transcript Is Not Critical for Efficient Replication In Vitro or In Vivo

P. Ghazal, D. Bloom, R. Sandri-Goldin, 2004, Journal of Virology.

Gene transfer to ovine corneal endothelium

D. Bloom, S. Klebe, D. Coster, 2001, Clinical & experimental ophthalmology.

A cAMP response element within the latency-associated transcript promoter of HSV-1 facilitates induced ocular reactivation in a mouse hyperthermia model.

D. Bloom, H. Thompson, R. Tran, 2001, Virology.

Simultaneous visualization of two Citrus tristeza virus genotypes provides new insights into the structure of multi-component virus populations in a host.

D. Bloom, A. Bak, M. Bergua, 2016, Virology.

Broad-spectrum non-nucleoside inhibitors of human herpesviruses.

R. Yolken, J. Milošević, S Kumar, 2015, Antiviral research.

Virology under the Microscope—a Call for Rational Discourse

Joshua R. Smith, A. Casadevall, M. Vignuzzi, 2023, mSphere.

Virology under the Microscope—a Call for Rational Discourse

Joshua R. Smith, A. Casadevall, M. Vignuzzi, 2023, mBio.

Molecular analysis of herpes simplex virus type 1 during epinephrine-induced reactivation of latently infected rabbits in vivo

D. Bloom, E. Wagner, J. G. Stevens, 1994, Journal of virology.

Herpes Simplex Virus Type-1: Replication, Latency, Reactivation and its Antiviral Targets

D. Bloom, I. C. Paixão, C. P. P. de Mello, 2016, Antiviral therapy.

Patterns of Herpes Simplex Virus 1 Infection in Neural Progenitor Cells

J. Milošević, V. Nimgaonkar, D. Bloom, 2020, Journal of Virology.

Experimental investigation of herpes simplex virus latency

D. Bloom, E. Wagner, Edward K Wagner, 1997, Clinical microbiology reviews.

Long-term expression of a reporter gene from latent herpes simplex virus in the rat hippocampus.

A. Tan, N. Maidment, D. Bloom, 1995, Brain research. Molecular brain research.

Ribozyme Gene Therapy of Herpes Simplex Infection in the Cornea

D. Bloom, A. Lewin, G. Schultz, 2006 .

HSV1 latent transcription and non-coding RNA: A critical retrospective

D. Bloom, Enrico R. Barrozo, Dane Phelan, 2017, Journal of Neuroimmunology.

Experimental Transmission of a Herpesvirus in Greek Tortoises (Testudo graeca)

P. Klein, D. Bloom, E. Jacobson, 2004, Veterinary pathology.

A Genomic Approach to Unravel Host-Pathogen Interaction in Chelonians: The Example of Testudinid Herpesvirus 3

D. Bloom, P. Roccabianca, E. Jacobson, 2015, PloS one.

Development of a Ribozyme Gene Therapy Against Herpes Simplex Virus Type I (HSV-1) Infection

D. Bloom, A. Lewin, G. Schultz, 2007 .

Human induced pluripotent stem cells for modeling of herpes simplex virus 1 infections

V. Nimgaonkar, D. Bloom, P. Kinchington, 2021, iPSCs for Studying Infectious Diseases.

HSV-1 LAT Promoter Deletion Viruses Exhibit Strain-Specific and LAT-Dependent Epigenetic Regulation of Latent Viral Genomes in Human Neurons

D. Bloom, T. Edwards, Tristan R. Grams, 2023, Journal of virology.

Herpes Simplex Virus 1 Strains 17syn+ and KOS(M) Differ Greatly in Their Ability To Reactivate from Human Neurons In Vitro

D. Bloom, T. Edwards, Tristan R. Grams, 2020, Journal of Virology.

In Vivo Knockdown of the Herpes Simplex Virus 1 Latency-Associated Transcript Reduces Reactivation from Latency

D. Bloom, A. Lewin, G. Schultz, 2018, Journal of Virology.

Wide Variations in Herpes Simplex Virus Type 1 Inoculum Dose and Latency-Associated Transcript Expression Phenotype Do Not Alter the Establishment of Latency in the Rabbit Eye Model

D. Bloom, J. Loutsch, E. Wagner, 2004, Journal of Virology.

A 437-base-pair deletion at the beginning of the latency-associated transcript promoter significantly reduced adrenergically induced herpes simplex virus type 1 ocular reactivation in latently infected rabbits

D. Bloom, J. Loutsch, H. Thompson, 1997, Journal of virology.

Decreased reporter gene expression during latent infection with HSV LAT promoter constructs.

D. Bloom, T. Margolis, J. G. Stevens, 1993, Virology.

Epigenetic regulation of latent HSV-1 gene expression.

D. Bloom, Dacia L. Kwiatkowski, Nicole V Giordani, 2010, Biochimica et biophysica acta.

Herpes Simplex Virus 1 MicroRNA miR-H8 Is Dispensable for Latency and Reactivation In Vivo

D. Bloom, D. Neumann, Sanae Nakayama, 2020, Journal of Virology.

The Herpes Simplex Viruses

D. Bloom, Adit Dhummakupt, 2016 .

Alphaherpesvirus Latency: A Dynamic State of Transcription and Reactivation.

D. Bloom, 2016, Advances in virus research.

Mutagenesis of a cAMP response element within the latency-associated transcript promoter of HSV-1 reduces adrenergic reactivation.

D. Bloom, R. Tran, J. G. Stevens, 1997, Virology.

During Herpes Simplex Virus Type 1 Infection of Rabbits, the Ability To Express the Latency-Associated Transcript Increases Latent-Phase Transcription of Lytic Genes

D. Bloom, James M. Hill, D. Neumann, 2008, Journal of Virology.

Microarray analysis of host gene expression for comparison between naïve and HSV-1 latent rabbit trigeminal ganglia

M. Popp, D. Bloom, James M. Hill, 2008, Molecular vision.

Overlapping subdeletions within a 348-bp in the 5' exon of the LAT region that facilitates epinephrine-induced reactivation of HSV-1 in the rabbit ocular model do not further define a functional element.

D. Bloom, James M. Hill, A. Mallakin, 2003, Virology.

Molecular Analysis ofHerpesSimplex Virus Type1during Epinephrine-Induced Reactivation ofLatently Infected Rabbits InVivo

D. Bloom, James M. Hill, J. G. Stevens, 1994 .

In vivo gene transfer to the brain cortex using a single injection of HSV-1 vector into the medial septum.

M. Stachowiak, T. Corso, D. Bloom, 2005, Folia morphologica.

The Herpes Simplex Virus Type 1 Latency-Associated Transcript (LAT) Enhancer/rcr Is Hyperacetylated during Latency Independently of LAT Transcription

D. Bloom, A. Amelio, Nicole J. Kubat, 2004, Journal of Virology.

Gene transfer into the central nervous system using herpes simplex virus-1 vectors.

E. Stachowiak, M. Stachowiak, G. Torres, 2000, Folia morphologica.

Long-term promoter activity during herpes simplex virus latency

D. Bloom, L. Feldman, J. Lokensgard, 1994, Journal of virology.

Role of Polycomb Proteins in Regulating HSV-1 Latency

D. Bloom, Adit Dhummakupt, Zachary L. Watson, 2013, Viruses.

HSV LAT AND NEURONAL SURVIVAL

D. Bloom, 2004, International reviews of immunology.

A novel approach for addressing diseases not yielding to effective vaccination? Immunization by replication-competent controlled virus

N. Vilaboa, D. Bloom, R. Voellmy, 2015, Expert review of vaccines.

Generation and use of recombinant reporter viruses for study of herpes simplex virus infections in vivo.

R. Jarman, D. Bloom, 1998, Methods.

An Intertypic Herpes Simplex Virus Helicase-Primase Complex Associated with a Defect in Neurovirulence Has Reduced Primase Activity

M. Challberg, D. Bloom, I. Barrera, 1998, Journal of Virology.

Commentary on, “Generation of Three-dimensional Human Neuronal Cultures: Application to Modeling CNS Viral Infections”

G. Apodaca, C. Chu, Nicholas M. Radio, 2018, Stem Cell Research & Therapy.

Generation of three-dimensional human neuronal cultures: application to modeling CNS viral infections

R. Yolken, C. Chu, Nicholas M. Radio, 2018, Stem Cell Research & Therapy.

Comparison of three cell-based drug screening platforms for HSV-1 infection.

R. Yolken, M. Schurdak, P. Piazza, 2017, Antiviral research.

Perillyl Alcohol and Perillic Acid Exert Efficient Action upon HSV-1 Maturation and Release of Infective Virus

D. Bloom, T. Quirico-Santos, Izabel Christina Nunes de Palmer Paixão, 2019, Antiviral therapy.

Mutational Inactivation of Herpes Simplex Virus 1 MicroRNAs Identifies Viral mRNA Targets and Reveals Phenotypic Effects in Culture

B. Cullen, O. Flores, D. Bloom, 2013, Journal of Virology.

Leveraging biological replicates to improve analysis in ChIP-seq experiments

Lauren M McIntyre, David Bloom, Justin Fear, 2014, Computational and structural biotechnology journal.

Specific Histone Tail Modification and Not DNA Methylation Is a Determinant of Herpes Simplex Virus Type 1 Latent Gene Expression

D. Bloom, R. Tran, Nicole J. Kubat, 2004, Journal of Virology.

Modeling Herpes Simplex Virus 1 Infections in Human Central Nervous System Neuronal Cells Using Two- and Three-Dimensional Cultures Derived from Induced Pluripotent Stem Cells

Simon C Watkins, L. Viggiano, M. Ikonomovic, 2019, Journal of Virology.

Truncated ring-A amaryllidaceae alkaloid modulates the host cell integrated stress response, exhibiting antiviral activity to HSV-1 and SARSCoV-2

J. Milošević, V. Nimgaonkar, D. Bloom, 2023, Scientific Reports.

Reduction in Severity of a Herpes Simplex Virus Type 1 Murine Infection by Treatment with a Ribozyme Targeting the UL20 Gene RNA

Jia Liu, D. Bloom, A. Lewin, 2008, Journal of Virology.

Recruitment to the cytoplasm of a cellular lamin-like protein from the nucleus during a poxvirus infection.

D. Morrison, R. Moyer, D. Bloom, 1989, Virology.

Fundamentals of Cancer Cell Biology and Molecular Targeting

V. Golubovskaya, W. Cance, S. Hochwald, 2008 .

Genome-Wide Surveillance of Genital Herpes Simplex Virus Type 1 From Multiple Anatomic Sites Over Time

Moriah L. Szpara, Daniel W. Renner, D. Bloom, 2018, The Journal of infectious diseases.

Personalized viral genomic investigation of herpes simplex virus 1 perinatal viremic transmission with dual fatality

Moriah L. Szpara, Daniel W. Renner, B. Ford, 2019, Cold Spring Harbor molecular case studies.

Regulated protein expression for in vivo gene therapy for neurological disorders: Progress, strategies, and issues

R. Mandel, D. Bloom, F. Manfredsson, 2012, Neurobiology of Disease.

The Polycomb Group Protein Bmi1 Binds to the Herpes Simplex Virus 1 Latent Genome and Maintains Repressive Histone Marks during Latency

D. Bloom, H. Thompson, Dacia L. Kwiatkowski, 2009, Journal of Virology.

Tissue-Specific Splicing of the Herpes Simplex Virus Type 1 Latency-Associated Transcript (LAT) Intron in LAT Transgenic Mice

D. Bloom, G. Rall, R. Tran, 2006, Journal of Virology.

Mice Transcript ( LAT ) Intron in LAT Transgenic Simplex Virus Type 1 Latency-Associated Tissue-Specific Splicing of the Herpes

D. Bloom, G. Rall, R. Tran, 2006 .

The Impaired Neurodevelopment of Human Neural Rosettes in HSV-1-Infected Early Brain Organoids

Simon C Watkins, V. Nimgaonkar, D. Bloom, 2022, Cells.

Novel nuclear signaling pathway mediates activation of fibroblast growth factor-2 gene by type 1 and type 2 angiotensin II receptors.

P. Maher, E. Stachowiak, M. Stachowiak, 2001, Molecular biology of the cell.

Azadirachta indica A. Juss bark extract and its Nimbin isomers restrict β-coronaviral infection and replication

D. Pal, R. Cohrs, R. Mahalingam, 2022, Virology.

A Chromatin Insulator-Like Element in the Herpes Simplex Virus Type 1 Latency-Associated Transcript Region Binds CCCTC-Binding Factor and Displays Enhancer-Blocking and Silencing Activities

D. Bloom, A. Amelio, Peterjon K. McAnany, 2006, Journal of Virology.

Treatment of infection and inflammation associated with COVID-19, multi-drug resistant pneumonia and fungal sinusitis by nebulizing a nanosilver solution

W. Hickerson, D. Bloom, T. Edwards, 2023, Nanomedicine: Nanotechnology, Biology and Medicine.

Respiratory function following bilateral mid-cervical contusion injury in the adult rat

P. Reier, D. Fuller, D. Bloom, 2012, Experimental Neurology.

Modeling Aβ42 Accumulation in Response to Herpes Simplex Virus 1 Infection: Two Dimensional or Three Dimensional?

M. Ikonomovic, V. Nimgaonkar, D. Bloom, 2020, Journal of Virology.

Modeling HSV-1 infections in human CNS neuronal cells using two-dimensional and three- dimensional cultures derived from induced pluripotent stem cells

L. Viggiano, M. Ikonomovic, V. Nimgaonkar, 2019 .

The ATM and Rad3-Related (ATR) Protein Kinase Pathway Is Activated by Herpes Simplex Virus 1 and Required for Efficient Viral Replication

D. Bloom, T. Edwards, C. Fisher, 2017, Journal of Virology.

Altering the Expression Kinetics of VP5 Results in Altered Virulence and Pathogenesis of Herpes Simplex Virus Type 1 in Mice

D. Bloom, R. Tran, E. Wagner, 2002, Journal of Virology.

Expression of the lacZ Reporter Gene in the Rat Basal Forebrain, Hippocampus, and Nigrostriatal Pathway Using a Nonreplicating Herpes Simplex Vector

A. Tan, N. Maidment, D. Bloom, 1996, Experimental Neurology.

Development of Recombinant HSV-Based Vaccine Vectors.

N. Vilaboa, D. Bloom, R. Voellmy, 2017, Methods in molecular biology.

Depletion of the Insulator Protein CTCF Results in Herpes Simplex Virus 1 Reactivation In Vivo

D. Bloom, Shannan D Washington, D. Neumann, 2018, Journal of Virology.

Immunization by Replication-Competent Controlled Herpesvirus Vectors

D. Bloom, R. Voellmy, R. Tran, 2018, Journal of Virology.

Reactivation of Latent Epstein-Barr Virus: A Comparison after Exposure to Gamma, Proton, Carbon, and Iron Radiation

D. Pierson, A. Feiveson, I. Plante, 2018, International journal of molecular sciences.

LAT expression during an acute HSV infection in the mouse.

R. Jarman, D. Bloom, E. Wagner, 1999, Virology.

Neuron-specific restriction of a herpes simplex virus recombinant maps to the UL5 gene

D. Bloom, J. G. Stevens, 1994, Journal of virology.

The CCCTC Binding Factor, CTRL2, Modulates Heterochromatin Deposition and the Establishment of Herpes Simplex Virus 1 Latency In Vivo

S. Frietze, D. Bloom, T. Edwards, 2019, Journal of Virology.

LAT Region Factors Mediating Differential Neuronal Tropism of HSV-1 and HSV-2 Do Not Act in Trans

J. Cohen, D. Bloom, T. Margolis, 2012, PLoS ONE.

Peripheral AAV Injection for Retrograde Transduction of Dorsal Root and Trigeminal Ganglia.

D. Bloom, D. Neumann, Zachary L. Watson, 2019, Methods in molecular biology.

Identification and characterization of two nonessential regions of the rabbitpox virus genome involved in virulence

K. Edwards, R. Moyer, D. Bloom, 1991, Journal of virology.

Cervical prephrenic interneurons in the normal and lesioned spinal cord of the adult rat

P. Reier, D. Fuller, A. Jones, 2008, The Journal of comparative neurology.

In Vivo Changes in the Patterns of Chromatin Structure Associated with the Latent Herpes Simplex Virus Type 1 Genome in Mouse Trigeminal Ganglia Can Be Detected at Early Times after Butyrate Treatment

D. Bloom, D. Neumann, P. Bhattacharjee, 2007, Journal of Virology.

Deacetylation of the Herpes Simplex Virus Type 1 Latency-Associated Transcript (LAT) Enhancer and a Decrease in LAT Abundance Precede an Increase in ICP0 Transcriptional Permissiveness at Early Times Postexplant

D. Bloom, A. Amelio, Nicole J. Kubat, 2006, Journal of Virology.

Transneuronal tracing to map connectivity in injured and transplanted spinal networks

D. Hoh, D. Bloom, E. Engel, 2022, Experimental Neurology.

A limited innate immune response is induced by a replication-defective herpes simplex virus vector following delivery to the murine central nervous system

H. Baker, Cecilia M. Lopez, D. Bloom, 2009, Journal of NeuroVirology.

Variations in Aspects of Neural Precursor Cell Neurogenesis in a Human Model of HSV-1 Infection

P. Piazza, V. Nimgaonkar, D. Bloom, 2022, Organogenesis.

Modeling Aβ42 Accumulation in Response to Herpes Simplex Virus 1 Infection: 2D or 3D?

M. Ikonomovic, V. Nimgaonkar, D. Bloom, 2020 .

Assessment of recovery in the hemiparkinson rat: Drug-induced rotation is inadequate

J. Moffett, E. Stachowiak, M. Stachowiak, 2005, Physiology & Behavior.

A revised HindIII map and sequence analysis of a large 'left-hand' non-essential region of the rabbit poxvirus genome.

R. Moyer, D. Bloom, D. Smith, 1993, Virus research.

FRAGILE X MENTAL RETARDATION PROTEIN REPLACEMENT RESTORES HIPPOCAMPAL SYNAPTIC FUNCTION IN A MOUSE MODEL OF FRAGILE X SYNDROME

T. Foster, D. Bloom, Z. Zeier, 2009, Gene Therapy.

Long-term expression of genes in vivo using non-replicating HSV vectors.

N. Maidment, D. Bloom, J. G. Stevens, 1994, Gene therapy.

Respiratory function following bilateral mid-cervical contusion injury in the adult rat

P. Reier, D. Fuller, D. Bloom, 2012, Experimental Neurology.

Generation of three-dimensional human neuronal cultures: application to modeling CNS viral infections

R. Yolken, C. Chu, Nicholas M. Radio, 2018, Stem Cell Research & Therapy.