P. Coulombe

P. Coulombe, V. Plourde, P. Huet, 1988, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Influence of the vitamin D hormonal status on the hepatic response to bromobenzene.

P. Coulombe, P. Haddad, M. Gascon-Barré, 1987, The Journal of pharmacology and experimental therapeutics.

Cytoskeleton | Intermediate Filaments

Hani S. Zaher, P. Coulombe, K. Bernot, 2021, Encyclopedia of Biological Chemistry III.

Intermediate filaments as effectors of differentiation.

P. Coulombe, Catherine J. Redmond, 2020, Current opinion in cell biology.

Report of the tenth annual International Pachyonychia Congenita Consortium meeting

E. Sprecher, D. Roop, P. Coulombe, 2013, The Journal of investigative dermatology.

Keratins and protein synthesis: the plot thickens

P. Coulombe, Juliane C. Kellner, 2009, The Journal of cell biology.

JCB: COMMENT

P. Coulombe, Juliane C. Kellner, 2009 .

INTERACTION BETWEEN THE INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR AND PDK 1 AS POTENTIAL THERAPEUTIC TARGET IN NEOPLASTIC CELLS ”

J. Herman, I. Pastan, M. Gottesman, 2007 .

Dose-dependent linkage, assembly inhibition and disassembly of vimentin and cytokeratin 5/14 filaments through plectin's intermediate filament-binding domain.

E. Fuchs, P. Traub, P. Coulombe, 2000, Journal of cell science.

Keratins Are Going Nuclear.

P. Coulombe, Justin T. Jacob, R. Hobbs, 2016, Developmental cell.

Language Rights, Individual and Communal

P. Coulombe, 1993 .

Biphasic mode of epithelial regeneration in murine pulmonary alveoli.

P. Coulombe, P. Filion, M. Côté, 1986, Analytical and quantitative cytology and histology.

A reporter transgene based on a human keratin 6 gene promoter is specifically expressed in the periderm of mouse embryos

P. Coulombe, S. Mazzalupo, 2001, Mechanisms of Development.

The Functional Diversity of Epidermal Keratins Revealed by the Partial Rescue of the Keratin 14 Null Phenotype by Keratin 16

P. Coulombe, R. Paladini, 1999, The Journal of cell biology.

Functional Differences between Keratins of Stratified and Simple Epithelia

E. Fuchs, Qian-chun Yu, P. Coulombe, 1998, The Journal of cell biology.

Pain mechanisms in hereditary palmoplantar keratodermas

M. Caterina, P. Coulombe, M. Polydefkis, 2019, The British journal of dermatology.

Towards a molecular definition of keratinocyte activation after acute injury to stratified epithelia.

P. Coulombe, 1997, Biochemical and biophysical research communications.

Expression of keratin K14 in the epidermis and hair follicle: insights into complex programs of differentiation

E. Fuchs, Raphael Kopan, P. Coulombe, 1989, The Journal of cell biology.

Keratin 17 modulates hair follicle cycling in a TNFα-dependent fashion

X. Tong, P. Coulombe, 2006 .

Oxidative stress management in the hair follicle: Could targeting NRF2 counter age‐related hair disorders and beyond?

R. Paus, A. Dinkova-Kostova, P. Coulombe, 2017, BioEssays : news and reviews in molecular, cellular and developmental biology.

Directed Expression of Keratin 16 to the Progenitor Basal Cells of Transgenic Mouse Skin Delays Skin Maturation

P. Coulombe, R. Paladini, 1998, The Journal of cell biology.

A keratin cytoskeletal protein regulates protein synthesis and epithelial cell growth

P. Coulombe, Seyun Kim, P. Wong, 2006, Nature.

Cytoplasmic intermediate filaments revealed as dynamic and multipurpose scaffolds

P. Coulombe, P. Wong, 2004, Nature Cell Biology.

Emerging role for the cytoskeleton as an organizer and regulator of translation

P. Coulombe, Pierre A. Coulombe, Seyun Kim, 2010, Nature Reviews Molecular Cell Biology.

Structure–function analyses of a keratin heterotypic complex identify specific keratin regions involved in intermediate filament assembly

Min-Sung Kim, Shuang Li, D. Leahy, 2019, bioRxiv.

Structural basis for heteromeric assembly and perinuclear organization of keratin filaments

Min-Sung Kim, D. Leahy, P. Coulombe, 2012, Nature Structural &Molecular Biology.

Elucidating the early stages of keratin filament assembly

E. Fuchs, P. Coulombe, 1990, The Journal of cell biology.

New consensus nomenclature for mammalian keratins

E. Birgitte Lane, Mathew W. Wright, E. Lane, 2006, The Journal of cell biology.

Type I Keratin 17 Protein Is Phosphorylated on Serine 44 by p90 Ribosomal Protein S6 Kinase 1 (RSK1) in a Growth- and Stress-dependent Fashion*

J. V. Van Eyk, L. A. Kane, P. Coulombe, 2011, The Journal of Biological Chemistry.

Doctorate Program in Molecular Oncology and Endocrinology

J. Herman, I. Pastan, M. Gottesman, 2006 .

Onset of Keratin 17 Expression Coincides with the Definition of Major Epithelial Lineages during Skin Development

K. McGowan, P. Coulombe, 1998, The Journal of cell biology.

Intermediate filament scaffolds fulfill mechanical, organizational, and signaling functions in the cytoplasm.

P. Coulombe, Seyun Kim, Seyun Kim, 2007, Genes & development.

Regulation of C-X-C chemokine gene expression by keratin 17 and hnRNP K in skin tumor keratinocytes

Erika Ilagan, M. Wills-Karp, P. Coulombe, 2015, The Journal of cell biology.

Periderm prevents pathological epithelial adhesions during embryogenesis.

R. Salonen, N. Hanley, M. Dixon, 2014, The Journal of clinical investigation.

Interaction between the keratin cytoskeleton and eEF1Bγ affects protein synthesis in epithelial cells

P. Coulombe, Seyun Kim, Seyun Kim, 2007, Nature Structural &Molecular Biology.

Do the ends justify the mean? Proline mutations at the ends of the keratin coiled-coil rod segment are more disruptive than internal mutations

A. Letai, E. Fuchs, P. Coulombe, 1992, The Journal of cell biology.

Contribution of olfactory neural stem cells to tissue maintenance and regeneration

R. Reed, P. Coulombe, C. T. Leung, 2007, Nature Neuroscience.

Type II epithelial keratin 6hf (K6hf) is expressed in the companion layer, matrix, and medulla in anagen-stage hair follicles.

J. Schweizer, P. Coulombe, L. Langbein, 2003, The Journal of investigative dermatology.

Overexpressed Transient Receptor Potential Vanilloid 3 Ion Channels in Skin Keratinocytes Modulate Pain Sensitivity via Prostaglandin E2

M. Caterina, Hyosang Lee, H. Bradshaw, 2008, The Journal of Neuroscience.

Keratin function in skin epithelia: a broadening palette with surprising shades.

P. Coulombe, L. Gu, 2007, Current opinion in cell biology.

Networking galore: intermediate filaments and cell migration.

P. Coulombe, B. Chung, Jeremy D. Rotty, 2013, Current opinion in cell biology.

Stressing the role of O-GlcNAc: linking cell survival to keratin modification

G. Hart, P. Coulombe, Jeremy D. Rotty, 2010, Nature Cell Biology.

Loss of Keratin 17 induces tissue-specific cytokine polarization and cellular differentiation in HPV16-driven cervical tumorigenesis in vivo

M. Han, P. Coulombe, R. Hobbs, 2016, Oncogene.

HNRNPK is retained in the cytoplasm by Keratin 19 to stabilize target mRNAs

M. Hafner, Xiantao Wang, D. Anastasakis, 2022, bioRxiv.

Tissues & Organs | Keratins and the Skin

P. Coulombe, K. Bernot, J. Schaffer, 2021, Encyclopedia of Biological Chemistry III.

Pathophysiology of pachyonychia congenita‐associated palmoplantar keratoderma: new insights into skin epithelial homeostasis and avenues for treatment

P. Coulombe, A. Zieman, Pierre A. Coulombe, 2019, The British journal of dermatology.

The Molecular Revolution in Cutaneous Biology: Keratin Genes and their Associated Disease: Diversity, Opportunities, and Challenges.

P. Coulombe, 2017, The Journal of investigative dermatology.

Keratins and the Skin

P. Coulombe, K. Bernot, Chang-Hun Lee, 2013 .

Identification of Novel Interaction between Annexin A2 and Keratin 17

J. V. Van Eyk, P. Coulombe, B. Chung, 2012, The Journal of Biological Chemistry.

Vibrissa hair bulge houses two populations of skin epithelial stem cells distinct by their keratin profile

X. Tong, J. Fradette, D. Larouche, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Defining the properties of the nonhelical tail domain in type II keratin 5: insight from a bullous disease-causing mutation.

P. Coulombe, L. Gu, 2005, Molecular biology of the cell.

Overcoming Functional Redundancy To Elicit Pachyonychia Congenita-Like Nail Lesions in Transgenic Mice

P. Coulombe, P. Wong, R. Domergue, 2005, Molecular and Cellular Biology.

Great promises yet to be fulfilled: defining keratin intermediate filament function in vivo.

X. Tong, P. Coulombe, S. Mazzalupo, 2004, European journal of cell biology.

Skin: an ideal model system to study keratin genes and proteins.

P. Coulombe, K. Bernot, P. Wong, 2004, Methods in cell biology.

Keratin 16 expression defines a subset of epithelial cells during skin morphogenesis and the hair cycle.

K. McGowan, P. Coulombe, K. Bernot, 2002, The Journal of investigative dermatology.

Using transgenic models to study the pathogenesis of keratin-based inherited skin diseases.

P. Coulombe, Y. Miyachi, K. Takahashi, 1999, Journal of dermatological science.

The Type I Keratin 19 Possesses Distinct and Context-dependent Assembly Properties*

J. Fradette, L. Germain, P. Coulombe, 1998, The Journal of Biological Chemistry.

Defining a Region of the Human Keratin 6a Gene That Confers Inducible Expression in Stratified Epithelia of Transgenic Mice*

P. Coulombe, Kenzo Takahashi, 1997, The Journal of Biological Chemistry.

Cloning and Characterization of Multiple Human Genes and cDNAs Encoding Highly Related Type II Keratin 6 Isoforms (*)

P. Coulombe, Kenzo Takahashi, R. Paladini, 1995, The Journal of Biological Chemistry.

Pairwise assembly determines the intrinsic potential for self-organization and mechanical properties of keratin filaments.

Denis Wirtz, D. Wirtz, P. Coulombe, 2002, Molecular Biology of the Cell.

Keratin Filament Suspensions Show Unique Micromechanical Properties*

D. Wirtz, P. Coulombe, Jingyuan Xu, 1999, The Journal of Biological Chemistry.

A small surface hydrophobic stripe in the coiled-coil domain of type I keratins mediates tetramer stability

P. Coulombe, K. Bernot, Chang-Hun Lee, 2005, The Journal of cell biology.

Keratin 6 regulates collective keratinocyte migration by altering cell–cell and cell–matrix adhesion

C. Parent, P. Coulombe, Hans B. Liu, 2018, The Journal of cell biology.

Wound Epithelialization: Accelerationg the Pace of Discovery

P. Coulombe, Pierre A. Coulombe, 2003 .

Wound epithelialization: accelerating the pace of discovery.

P. Coulombe, Pierre A Coulombe, 2003, The Journal of investigative dermatology.

An ex vivo assay to assess the potential of skin keratinocytes for wound epithelialization.

P. Coulombe, M. Wawersik, S. Mazzalupo, 2002, The Journal of investigative dermatology.

The co-repressor hairless has a role in epithelial cell differentiation in the skin

G. Beaudoin, P. Coulombe, C. Thompson, 2004, Development.

A wound-induced keratin inhibits Src activity during keratinocyte migration and tissue repair

P. Coulombe, Jeremy D. Rotty, Jeremy D Rotty, 2012, The Journal of cell biology.

Keratin intracellular concentration revisited: Implications for keratin function in surface epithelia

J. Margolick, P. Coulombe, Xia Feng, 2012, The Journal of investigative dermatology.

A 'hot-spot' mutation alters the mechanical properties of keratin filament networks

D. Wirtz, P. Coulombe, S. Yamada, 2001, Nature Cell Biology.

Citizenship and Official Bilingualism in Canada

P. Coulombe, 2000 .

Endocannabinoids as emerging suppressors of angiogenesis and breast tumor growth and metastatic spreading ”

J. Herman, I. Pastan, M. Gottesman, 2008 .

Self-organization of keratin intermediate filaments into cross-linked networks

P. Coulombe, Chang-Hun Lee, 2009, The Journal of cell biology.

Intermediate filament proteins and their associated diseases.

M. Omary, W. McLean, P. Coulombe, 2004, The New England journal of medicine.

Inhibiting EGFR Signaling Holds Promise for Treating Palmoplantar Keratodermas.

P. Coulombe, A. Orosco, 2023, The Journal of investigative dermatology.

Acute sensitivity of BHT-induced alveolar toxicity to a diquat challenge in murine lungs.

P. Coulombe, M. Côté, G. Lassonde, 1987, Experimental and molecular pathology.

Skin Keratins.

P. Coulombe, Fengrong Wang, A. Zieman, 2016, Methods in enzymology.

Altered keratinocyte differentiation is an early driver of keratin mutation-based palmoplantar keratoderma.

P. Coulombe, Jingqun Ma, Brian G. Poll, 2019, Human molecular genetics.

Complementary Roles of Specific Cysteines in Keratin 14 toward the Assembly, Organization, and Dynamics of Intermediate Filaments in Skin Keratinocytes*

P. Coulombe, Xia Feng, 2015, The Journal of Biological Chemistry.

The roles of K5 and K14 head, tail, and R/K L L E G E domains in keratin filament assembly in vitro

E. Fuchs, P. Coulombe, A. K. Wilson, 1992, The Journal of cell biology.

Epidermolysis bullosa simplex: a paradigm for disorders of tissue fragility.

E. Fuchs, P. Coulombe, M. Kerns, 2009, The Journal of clinical investigation.

Increased levels of keratin 16 alter epithelialization potential of mouse skin keratinocytes in vivo and ex vivo.

P. Coulombe, M. Wawersik, S. Mazzalupo, 2001, Molecular biology of the cell.

Estimation of collagen content of liver specimens. Variation among animals and among hepatic lobes in cirrhotic rats.

P. Coulombe, V. Plourde, P. Huet, 1989, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Gefitinib and Radiotherapy in patients with locally advanced inoperable squamous cell carcinoma of the head and neck ”

J. Herman, I. Pastan, M. Gottesman, 2008 .

Multinational Democracies: Federalist language policies: the cases of Canada and Spain

P. Coulombe, 2001 .

Deletions in epidermal keratins leading to alterations in filament organization in vivo and in intermediate filament assembly in vitro

E. Fuchs, P. Coulombe, K. Albers, 1990, The Journal of cell biology.

A transgenic mouse model with an inducible skin blistering disease phenotype.

P. Coulombe, K. Takahashi, Pierre A. Coulombe, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Transgenic mice expressing a mutant keratin 10 gene reveal the likely genetic basis for epidermolytic hyperkeratosis.

E. Fuchs, P. Coulombe, E Fuchs, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Docetaxel in adjuvant therapy of breast cancer : results of the TAXIT 216 multicenter phase III trial ”

J. Herman, I. Pastan, M. Gottesman, 2008 .

Mathematical modeling of the impact of actin and keratin filaments on keratinocyte cell spreading.

Jin Seob Kim, J. S. Kim, P. Coulombe, 2012, Biophysical journal.

The nonhelical tail domain of keratin 14 promotes filament bundling and enhances the mechanical properties of keratin intermediate filaments in vitro

D. Wirtz, P. Coulombe, S. Yamada, 2001, The Journal of cell biology.

Keratin intermediate filament proteins – novel regulators of inflammation and immunity in skin

P. Coulombe, J. Lessard, R. Hobbs, 2012, Journal of Cell Science.

Type I keratin 16 forms relatively unstable tetrameric assembly subunits with various type II keratin partners: biochemical basis and functional implications.

P. Coulombe, M. Wawersik, R. Paladini, 1998, The Biological bulletin.

Capturing intermediate filament networks

P. Coulombe, 2022, eLife.

Keratin 17 regulates nuclear morphology and chromatin organization

R. Nair, P. Coulombe, M. Matunis, 2020, Journal of Cell Science.

Keratin 17 regulates nuclear morphology and chromatin organization

R. Nair, P. Coulombe, M. Matunis, 2020, Journal of Cell Science.

Language Rights in French Canada

P. Coulombe, 1995 .

Detection of ginkgolide A in Ginkgo biloba cell cultures

D. Carrier, P. Coulombe, R. Neufeld, 1991, Plant Cell Reports.

Sexual Dimorphism in Response to an NRF2 Inducer in a Model for Pachyonychia Congenita.

P. Coulombe, M. Kerns, R. Lu, 2017, Journal of Investigative Dermatology.

Forced expression of keratin 16 alters the adhesion, differentiation, and migration of mouse skin keratinocytes.

P. Coulombe, M. Wawersik, 2000, Molecular biology of the cell.

Randomized, split‐body, single‐blinded clinical trial of topical broccoli sprout extract: Assessing the feasibility of its use in keratin‐based disorders

P. Coulombe, J. Fahey, S. Sung, 2017, Journal of the American Academy of Dermatology.

Epidermolysis bullosa simplex: a paradigm for disorders of tissue fragility.

E. Fuchs, P. Coulombe, M. Kerns, 2009, The Journal of clinical investigation.

Preview. SKPing a hurdle: Sox2 and adult dermal stem cells.

P. Coulombe, Juliane C. Kellner, 2009, Cell stem cell.

Skin Keratins.

P. Coulombe, Fengrong Wang, A. Zieman, 2016, Methods in enzymology.

Heterogeneous distribution of phospholipids in membranes along the secretory pathway in pancreatic B‐cells

P. Coulombe, M. Bendayan, 1989, Biology of the cell.

Intermediate filament cytoskeleton

M. Omary, P. Coulombe, 2004 .

Altered keratinocyte differentiation is an early driver of keratin mutation-based palmoplantar keratoderma.

P. Coulombe, Jingqun Ma, Brian G. Poll, 2019, Human molecular genetics.

Sam68 is required for the growth and survival of nonmelanoma skin cancer

P. Coulombe, Kai Fu, F. Wan, 2019, Cancer medicine.

Loss of keratin 6 (K6) proteins reveals a function for intermediate filaments during wound repair

P. Coulombe, P. Wong, 2003, The Journal of cell biology.

Keratin 19 binds and regulates cytoplasmic HNRNPK mRNA targets in triple-negative breast cancer

Xiantao Wang, D. Anastasakis, P. Coulombe, 2023, BMC Molecular and Cell Biology.