J. Mizuguchi

发表

Efficient gene transfer to hepatoblastoma cells through asialoglycoprotein receptor and expression under the control of the cyclin A promoter.

T. Nikaido, Y. Koyanagi, Y. Magami, 2003, Biological & pharmaceutical bulletin.

STAT3 Is Indispensable to IL-27-Mediated Cell Proliferation but Not to IL-27-Induced Th1 Differentiation and Suppression of Proinflammatory Cytokine Production1

K. Takeda, T. Yoshimoto, J. Mizuguchi, 2008, The Journal of Immunology.

Hemextin AB Complex – A Snake Venom Anticoagulant Protein Complex That Inhibits Factor VIIa Activity

R. Kini, J. Mizuguchi, S. Iwanaga, 2006, Pathophysiology of Haemostasis and Thrombosis.

Environment‐induced epigenetic reprogramming in genomic regulatory elements in smoking mothers and their children

Roland Eils, Stefan Wiemann, Matthias Schlesner, 2016, Molecular systems biology.

Ovalbumin-liposome conjugate induces IgG but not IgE antibody production.

J. Mizuguchi, T. Uchida, K. Komuro, 1996, International archives of allergy and immunology.

B cell stimulatory factor 1 (interleukin 4) is a potent costimulant for normal resting T lymphocytes

E. Shevach, T. Mosmann, J. Mizuguchi, 1987, The Journal of experimental medicine.

Differential regulation of T‐cell dependent and T‐cell independent antibody responses through arginine methyltransferase PRMT1 in vivo

H. Kiyonari, K. Sudo, J. Mizuguchi, 2016, FEBS letters.

Arginine methylation regulates antibody responses through modulating cell division and isotype switching in B cells

J. Mizuguchi, K. Hata, Kikumi Hata, 2013, Microbiology and immunology.

Role for Btg1 and Btg2 in growth arrest of WEHI-231 cells through arginine methylation following membrane immunoglobulin engagement.

J. Mizuguchi, K. Hata, Kana Nishijima, 2007, Experimental cell research.

Fibrinogen Binds to Integrin α5β1via the Carboxyl-Terminal RGD Site of the Aα-Chain

J. Mizuguchi, S. Iwanaga, D. Farrell, 2000 .

Fibrinogen binds to integrin alpha(5)beta(1) via the carboxyl-terminal RGD site of the Aalpha-chain.

J. Mizuguchi, S. Iwanaga, D. Farrell, 2000, Journal of Biochemistry (Tokyo).

A double-edged sword in B-cell-targeted therapy for inflammatory diseases

J. Mizuguchi, 2009, Expert review of clinical immunology.

Potent Antitumor Activity of Interleukin-27

Maria Laura Belladonna, Y. Koyanagi, M. L. Belladonna, 2004, Cancer Research.

Interleukin-27: Regulation of Immune Responses and Disease Development by a Pleiotropic Cytokine with Pro- and Anti-inflammatory Properties

T. Yoshimoto, J. Mizuguchi, Izuru Mizoguchi, 2014 .

IL-27 promotes nitric oxide production induced by LPS through STAT1, NF-κB and MAPKs.

T. Yoshimoto, J. Mizuguchi, K. Ogura, 2013, Immunobiology.

IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells: a novel therapeutic way for Th2-mediated allergic inflammation.

K. Nakanishi, T. Yoshimoto, J. Mizuguchi, 2010, The Journal of Immunology.

Interleukin-27 directly induces differentiation in hematopoietic stem cells.

H. Nakauchi, J. Seita, M. Kudo, 2008, Blood.

Th2-Mediated Allergic Inflammation Th2 Cells: A Novel Therapeutic Way for Th2 Cytokines Production from Polarized IL-27 Suppresses Th2 Cell Development and

K. Nakanishi, T. Yoshimoto, J. Mizuguchi, 2007 .

IL-27 Suppresses Th2 Cell Development and Th2 Cytokines Production from Polarized Th2 Cells: A Novel Therapeutic Way for Th2-Mediated Allergic Inflammation1

K. Nakanishi, T. Yoshimoto, J. Mizuguchi, 2007, The Journal of Immunology.

Augmentation of Effector CD8+ T Cell Generation with Enhanced Granzyme B Expression by IL-27 1

T. Yoshimoto, J. Mizuguchi, T. Owaki, 2005, The Journal of Immunology.

Expression by IL-27 Generation with Enhanced Granzyme B T Cell + Augmentation of Effector CD 8

T. Yoshimoto, J. Mizuguchi, T. Owaki, 2005 .

A Critical Role of Fc Receptor-Mediated Antibody-Dependent Phagocytosis in the Host Resistance to Blood-Stage Plasmodium berghei XAT Infection1

Y. Iwakura, H. Nariuchi, T. Yoshimoto, 2001, The Journal of Immunology.

Proinflammatory Cytokine Production Th 1 Differentiation and Suppression of Cell Proliferation but Not to IL-27-Induced STAT 3 Is Indispensable to IL-27-Mediated Mizuguchi and Takayuki Yoshimoto

K. Takeda, T. Yoshimoto, J. Mizuguchi, 2008 .

The role of costimulatory molecules B7-1 and B7-2 in mice with experimental autoimmune uveoretinitis

J. Mizuguchi, K. Okumura, H. Yagita, 1999, Graefe's Archive for Clinical and Experimental Ophthalmology.

Receptor Cross-Linkage Stimulates B Cell Activation

W. Paul, P. Hornbeck, J. Mizuguchi, 1987 .

Antigen Chemically Coupled to the Surface of Liposomes Are Cross-Presented to CD8+ T Cells and Induce Potent Antitumor Immunity1

Mitsuhiro Nishida, J. Mizuguchi, Yuriko Tanaka, 2006, The Journal of Immunology.

Immunological Control of Chronic Myeloid Leukemia Leading to Treatment-Free

J. Mizuguchi, K. Ohyashiki, J. Ohyashiki, 2014 .

OVA-bound nanoparticles induce OVA-specific IgG1, IgG2a, and IgG2b responses with low IgE synthesis.

J. Mizuguchi, S. Yagyu, Takahiro Seki, 2014, Vaccine.

Sustained upregulation of effector natural killer cells in chronic myeloid leukemia after discontinuation of imatinib

T. Yoshimoto, J. Mizuguchi, K. Inokuchi, 2013, Cancer science.

Avathrin: a novel thrombin inhibitor derived from a multicopy precursor in the salivary glands of the ixodid tick, Amblyomma variegatum

R. Kini, C. Koh, K. Swaminathan, 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Molecular cloning and characterization of the mouse thymocyte protein gene.

T. Yoshimoto, J. Mizuguchi, S. Kamiya, 2002, Gene.

Pivotal Roles of T-Helper 17-Related Cytokines, IL-17, IL-22, and IL-23, in Inflammatory Diseases

T. Yoshimoto, J. Mizuguchi, Y. Kawakami, 2013, Clinical & developmental immunology.

Modulation of mThy28 nuclear protein expression during thymocyte development.

J. Yamada, T. Yoshimoto, J. Mizuguchi, 2003, Tissue & cell.

Turnover of acinar and islet cells in the pancreas of monosodium glutamate-treated obese mice.

Y. Magami, T. Azuma, T. Hattori, 2003, Obesity research.

Enhanced expression of the apoptosis inducing ligand TRAIL in mononuclear cells after myocardial infarction.

J. Mizuguchi, A. Yamashina, H. Nakajima, 2003, Japanese heart journal.

Intraocular cytokine quantification of experimental autoimmune uveoretinitis in rats.

J. Mizuguchi, J. Sakai, A. Okada, 1998, Ocular immunology and inflammation.

Effect of type I interferon on experimental autoimmune uveoretinitis in rats.

J. Mizuguchi, J. Sakai, A. Okada, 1998, Ocular immunology and inflammation.

Antigen receptor‐mediated calcium signals in B cells as revealed by confocal fluorescence microscopy

M. Nakanishi, J. Mizuguchi, H. Yamada, 1991, FEBS letters.

Regulation of B‐Lymphocyte Activation, Proliferation, and Differentiation

W. Paul, P. Hornbeck, C. Snapper, 1987, Annals of the New York Academy of Sciences.

c-Jun-NH2-terminal kinase potentiates apoptotic cell death in response to carboplatin in B lymphoma cells

J. Mizuguchi, E. Takada, Kikumi Hata, 2008, Cancer Chemotherapy and Pharmacology.

Association of B cell antigen receptor with protein tyrosine kinase Lyn.

T. Yamamoto, J. Mizuguchi, T. Kakiuchi, 1991, Science.

Blockade of the OX40 ligand prolongs corneal allograft survival

J. Mizuguchi, K. Okumura, H. Yagita, 2007, European journal of immunology.

B-cell activation stimulated by monoclonal anti-Lyb2.1 antibody is mediated through a receptor distinct from the BSF-1 receptor.

F. Finkelman, J. Mizuguchi, J. Mond, 1987, Cellular immunology.

Interferon-beta-induced activation of c-Jun NH2-terminal kinase mediates apoptosis through up-regulation of CD95 in CH31 B lymphoma cells.

L. Heasley, J. Mizuguchi, M. Moriyama, 2005, Experimental cell research.

Involvement of TRAIL/TRAIL-R interaction in IFN-alpha-induced apoptosis of Daudi B lymphoma cells.

C. Ibukiyama, J. Mizuguchi, A. Yamashina, 2001, Cytokine.

Etoposide-mediated sensitization of squamous cell carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced loss in mitochondrial membrane potential.

J. Mizuguchi, H. Toyota, M. Itoh, 2003, Oral oncology.

Chemotherapeutic agents sensitize sarcoma cell lines to tumor necrosis factor‐related apoptosis‐inducing ligand‐induced caspase‐8 activation, apoptosis and loss of mitochondrial membrane potential

J. Mizuguchi, Hidekazu Suzuki, A. Imakiire, 2003, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

IgE-specific unresponsiveness in mice induced by ovalbumin coupled with murine red blood cells.

J. Mizuguchi, T. Uchida, S. Naito, 1994, International archives of allergy and immunology.

Thy28 protects against anti-CD3-mediated thymic cell death in vivo

K. Sudo, J. Mizuguchi, T. Kakiuchi, 2014, Apoptosis.

Two types of mu chain complexes are expressed during differentiation from pre‐B to mature B cells.

K. Shigemoto, T. Shirasawa, J. Mizuguchi, 1990, The EMBO journal.

Hemextin AB Complex, a Unique Anticoagulant Protein Complex from Hemachatus haemachatus (African Ringhals Cobra) Venom That Inhibits Clot Initiation and Factor VIIa Activity*

R. Kini, J. Mizuguchi, S. Iwanaga, 2005, Journal of Biological Chemistry.

Bcl-xL confers multi-drug resistance in several squamous cell carcinoma cell lines

J. Mizuguchi, H. Chiba, H. Toyota, 2002 .

Participation of Bcl-2/Bax-α in Glutamate-induced Apoptosis of Human Glioblastoma Cells

T. Nishi, Hiroshi Ito, J. Mizuguchi, 1999, Journal of Neuro-Oncology.

Peptide-mediated suppression of experimental autoimmune uveoretinitis in mice: development of a peptide vaccine.

J. Mizuguchi, M. Takeuchi, T. Kezuka, 1996, International immunology.

ImmunityCells and Induce Potent Antitumor T + Liposomes Are Cross-Presented to CD 8 Antigen Chemically Coupled to the Surface of Mizuguchi

Mitsuhiro Nishida, J. Mizuguchi, Yuriko Tanaka, 2006 .

BcI-xL antisense treatment sensitizes Bcl-xL-overexpressing squamous cell carcinoma cells to carboplatin.

J. Mizuguchi, H. Chiba, M. Itoh, 2002, Oral oncology.

Phosphorylation of ASC acts as a molecular switch controlling the formation of speck-like aggregates and inflammasome activity

V. Tybulewicz, J. Mizuguchi, I. Kawamura, 2013, Nature Immunology.

IL-27 Suppresses CD28-Medicated IL-2 Production through Suppressor of Cytokine Signaling 31

K. Takeda, T. Yoshimoto, J. Mizuguchi, 2006, The Journal of Immunology.

Signaling 3 Production through Suppressor of Cytokine IL-27 Suppresses CD28-Medicated IL-2

K. Takeda, T. Yoshimoto, J. Mizuguchi, 2006 .

Signaling 3 Production through Suppressor of Cytokine IL-27 Suppresses CD 28-Medicated IL-2 Takayuki Yoshimoto

K. Takeda, T. Yoshimoto, J. Mizuguchi, 2006 .

IL-27 suppresses RANKL expression in CD4+ T cells in part through STAT3.

T. Yoshimoto, J. Mizuguchi, S. Kamiya, 2011, Immunology letters.

Positive Modulation of IL-12 Signaling by Sphingosine Kinase 2 Associating with the IL-12 Receptor β1 Cytoplasmic Region 1

Y. Magami, H. Fujiwara, T. Yoshimoto, 2003, The Journal of Immunology.

Anticancer effects of phenoxazine derivatives combined with tumor necrosis factor-related apoptosis-inducing ligand on pancreatic cancer cell lines, KLM-1 and MIA-PaCa-2.

S. Akiyama, K. Shirato, K. Imaizumi, 2006, Oncology reports.

Preparation of a diphtheria toxin-pullulan conjugate that elicits good IgG antibody production with poor IgE synthesis.

J. Mizuguchi, T. Matuhasi, T. Komiya, 1990, Vaccine.

Differential sensitivity to antigenic competition in antigen-specific and -nonspecific antigen presentation by B cells.

H. Nariuchi, J. Mizuguchi, T. Kakiuchi, 1995, Immunobiology.

Induction of acquired factor IX inhibitors in cynomolgus monkey (Macaca fascicularis): a new primate model of hemophilia B.

J. Mizuguchi, Y. Nakatomi, K. Tomokiyo, 2001, Thrombosis research.

Factor XI and Factor IX Deficient Mice

J. Mizuguchi, K. Tomokiyo, 1998 .

Double Targeted Gene Disruption of TFPI and FVII in Mice

J. Mizuguchi, T. Hamamoto, T. Araki, 1999 .

Factor VII Deficient Mice

J. Mizuguchi, K. Tomokiyo, K. Soejima, 1998 .

Plasminogen Deficient Mice

J. Mizuguchi, H. Kaetsu, 1997 .

Regulation of B-lymphocyte activation, proliferation, and immunoglobulin secretion.

W. Paul, P. Hornbeck, K. Nakanishi, 1986, Cellular immunology.

Cleavage of Bax-α and Bcl-xL during carboplatin-mediated apoptosis in squamous cell carcinoma cell line

J. Mizuguchi, H. Chiba, E. Takada, 2000 .

Induction of apoptosis and/or necrosis following exposure to antitumour agents in a melanoma cell line, probably through modulation of Bcl-2 family proteins

J. Mizuguchi, R. Tsuboi, Y. Kato, 2003, Melanoma research.

Differential responses of p566'n and p53IYn, products of alternatively spliced lyn mRNA, on stimulation of B-cell antigen receptor

J. Mizuguchi, Y. Yamanashi, M. Takeuchi, 2022 .

B lymphocyte activation. The roles of receptor cross-linkage and BSF-1.

W. Paul, P. Hornbeck, J. Mizuguchi, 1987, Advances in experimental medicine and biology.

Regulation of B Lymphocyte Activation: The Roles of Receptor Cross-Linkage and B Cell Stimulatory Factor-1 (BSF-1)

M. Brown, W. Paul, P. Hornbeck, 1986 .

Genomic organization and characterization of the promoter for the E2A gene.

J. Mizuguchi, Kikumi Hata, 2004, Gene.

Stepwise Assembly of Fibrinogen Is Assisted by the Endoplasmic Reticulum Lectin-Chaperone System in HepG2 Cells

I. Wada, J. Mizuguchi, Seisuke Arai, 2013, PloS one.

Factor V Deficient Mice

J. Mizuguchi, S. Iwanaga, T. Hamamoto, 1997 .

Regulatory role of CD4/L3T4 molecules in IL-2 production by affecting intracellular Ca2+ concentration of T cell clone stimulated with soluble anti-CD3.

H. Nariuchi, J. Mizuguchi, T. Tamura, 1990, Journal of immunology.

Efficient neutralization of tetanus toxin in vivo.

J. Mizuguchi, Y. Sato, T. Yoshida, 1982 .

Apoptosis induction preceded by mitochondrial depolarization in multiple myeloma cell line U266 by 2-aminophenoxazine-3-one.

S. Akiyama, K. Shirato, K. Imaizumi, 2008, Biological & pharmaceutical bulletin.

Enforced expression of a truncated form of Bax-alpha (tBax) driven by human telomerase reverse transcriptase (hTERT) promoter sensitizes tumor cells to chemotherapeutic agents or tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).

S. Kyo, S. Kondo, J. Mizuguchi, 2006, Anticancer research.

Antiproliferative Activity of IL-27 on Melanoma

H. Nagai, T. Yoshimoto, J. Mizuguchi, 2008 .

Engagement of membrane immunoglobulin enhances Id3 promoter activity in WEHI-231 B lymphoma cells

Xiao-Jun Li, J. Mizuguchi, Kikumi Hata, 2005, Acta Pharmacologica Sinica.

Synergistic antitumor effect by coexpression of chemokine CCL21/SLC and costimulatory molecule LIGHT

Y. Koyanagi, Y. Magami, K. Tamada, 2004, Cancer Gene Therapy.

Id3-mediated enhancement of cisplatin-induced apoptosis in a sarcoma cell line MG-63.

J. Mizuguchi, T. Koyama, Hidekazu Suzuki, 2004, Anticancer research.

Changes in cell attachment by RSV transformation in rat liver epithelial cells.

J. Mizuguchi, K. Mashima, 1992, Biochemical and biophysical research communications.

Participation of Bax-α in IFN-α-Mediated Apoptosis in Daudi B Lymphoma Cells

J. Mizuguchi, E. Takada, I. Yoshihama, 1998 .

Participation of tyrosine kinase in capping, internalization, and antigen presentation through membrane immunoglobulin in BAL17 B lymphoma cells

J. Mizuguchi, T. Kakiuchi, Y. Gyotoku, 1993, FEBS letters.

Suppressive effects of a novel compound on interphotoreceptor retinoid-binding protein-induced experimental autoimmune uveoretinitis in rats

J. Mizuguchi, Y. Kaneko, T. Kezuka, 1999 .

Targeted Gene Disruption of Fibronectin in Mice

J. Mizuguchi, Y. Nakatomi, M. Hirakami, 1998 .

Increased degradation of protein kinase C without diminution of mRNA level after treatment of WEHI-231 B lymphoma cells with phorbol esters.

K. Suzuki, K. Huang, J. Mizuguchi, 1988, Biochemical and biophysical research communications.

CD27 synergizes with CD40 to induce IgM, IgG, and IgA antibody responses of peripheral blood B cells in the presence of IL-2 and IL-10.

J. Mizuguchi, T. Hirano, I. Yonekubo, 2003, Immunology letters.

Calpain-induced Bax-cleavage product is a more potent inducer of apoptotic cell death than wild-type Bax.

T. Yoshimoto, J. Mizuguchi, M. Moriyama, 2003, Cancer letters.

IL-27 suppresses CD28-mediated [correction of medicated] IL-2 production through suppressor of cytokine signaling 3.

K. Takeda, T. Yoshimoto, J. Mizuguchi, 2006, Journal of Immunology.

The 99 and 170 Loop-modified Factor VIIa Mutants Show Enhanced Catalytic Activity without Tissue Factor*

J. Mizuguchi, S. Iwanaga, K. Tomokiyo, 2002, The Journal of Biological Chemistry.

Large-scale preparation of human thrombin: polyethylene glycol potentiates the factor Xa-mediated activation of prothrombin.

J. Mizuguchi, Y. Ogata, T. Hamamoto, 1998, Thrombosis research.

Molecular Evolution of Blood Clotting Factors with Special Reference to Fibrinogen and von Willebrand Factor

J. Mizuguchi, S. Iwanaga, S. Gokudan, 2008 .

Type I interferons as immunoregulatory molecules; implications for therapy in experimental autoimmune uveoretinitis.

J. Mizuguchi, M. Takeuchi, M. Usui, 2002, Archivum immunologiae et therapiae experimentalis.

Antiproliferative Activity of IL-27 on Melanoma1

H. Nagai, T. Yoshimoto, J. Mizuguchi, 2008, The Journal of Immunology.

Cytochrome c Release, Mitochondrial Membrane Depolarization, Caspase-3 Activation, and Bax-α Cleavage During IFN-α-Induced Apoptosis in Daudi B Lymphoma Cells

J. Mizuguchi, N. Yanase, H. Ikegami, 2000 .

Prevention of Anti-IgM-Induced Apoptosis Accompanying G1 Arrest in B Lymphoma Cells Overexpressing Dominant-Negative Mutant Form of c-Jun N-Terminal Kinase 11

J. Mizuguchi, E. Takada, J. Suzuki, 2001, The Journal of Immunology.

Prevention of Anti-IgM-Induced Apoptosis Accompanying G 1 Arrest in B Lymphoma Cells Overexpressing Dominant-Negative Mutant Form of c-Jun

J. Mizuguchi, E. Takada, H. Toyota, 2001 .

Tyrosine protein kinase is involved in anti-IgM-mediated signaling in BAL17 B lymphoma cells.

T. Yamamoto, Y. Uehara, H. Nariuchi, 1992, Journal of immunology.

T‐Cell Unresponsiveness in vivo and in vitro: Fine Specificity of Induction and Molecular Characterization of the Unresponsive State

R. Schwartz, J. Mizuguchi, H. Quill, 1987, Immunological reviews.

TGF-beta is necessary for induction of IL-23R and Th17 differentiation by IL-6 and IL-23.

K. Takeda, T. Yoshimoto, J. Mizuguchi, 2009, Biochemical and biophysical research communications.

Failure of signaling through a chimeric class I-immunoglobulin molecule expressed on the surface of transfected B lymphoma cells and cells of transgenic mice.

W. Paul, D. Margulies, J. Mizuguchi, 1992, Cellular immunology.

Targeted Gene Deletions of Plasminogen/Plasmin System in Mice

J. Mizuguchi, H. Kaetsu, 1998 .

IL-27 Enhances the Expression of TRAIL and TLR3 in Human Melanomas and Inhibits Their Tumor Growth in Cooperation with a TLR3 Agonist Poly(I:C) Partly in a TRAIL-Dependent Manner

H. Nagai, T. Yoshimoto, J. Mizuguchi, 2013, PloS one.

A characteristic property of vitamin K-dependent plasma protein Z.

S. Kawabata, J. Mizuguchi, S. Iwanaga, 1988, Journal of biochemistry.

Protein Z Deficient Mice and Protein Z-dependent Protease Inhibitor

J. Mizuguchi, T. Hamamoto, J. Shimoda, 2000 .

Phorbol myristate acetate inhibits increases in membrane fluidity induced by anti-IgM in B cells.

M. Nakanishi, J. Mizuguchi, Y. Arata, 1988, Journal of immunology.

Membrane IgM, IgD, and IgG act as signal transmission molecules in a series of B lymphomas.

S. Morrison, W. Paul, J. Mizuguchi, 1986, Journal of immunology.

Phorbol myristate acetate inhibits anti-IgM-mediated signaling in resting B cells.

J. H. Li, W. Paul, J. Mizuguchi, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Requirement for JNK-dependent upregulation of BimL in anti-IgM-induced apoptosis in murine B lymphoma cell lines WEHI-231 and CH31.

J. Mizuguchi, E. Takada, Kikumi Hata, 2006, Experimental cell research.

CD40 Ligand Rescues Inhibitor of Differentiation 3-Mediated G1 Arrest Induced by Anti-IgM in WEHI-231 B Lymphoma Cells1

T. Yoshimoto, J. Mizuguchi, Kikumi Hata, 2004, The Journal of Immunology.

Lymphoma Cells Induced by Anti-IgM in WEHI-231 B Arrest 1 Differentiation 3-Mediated G CD 40 Ligand Rescues Inhibitor of Kikumi Hata

T. Yoshimoto, J. Mizuguchi, Kikumi Hata, 2004 .

PKC-δ mediates interferon-α-induced apoptosis through c-Jun NH2-terminal kinase activation

J. Mizuguchi, N. Yanase, A. Hoshika, 2012, BMC Cell Biology.

Immunosurveillance markers may predict patients who can discontinue imatinib therapy without relapse

T. Yoshimoto, J. Mizuguchi, T. Tauchi, 2014, Oncoimmunology.

Interferon-α induces transient upregulation of c-FLIP through NF-κB activation

J. Mizuguchi, N. Yanase, A. Hoshika, 2008 .

Interferon-alpha induces transient upregulation of c-FLIP through NF-kappaB activation.

J. Mizuguchi, N. Yanase, A. Hoshika, 2008, Experimental cell research.

Thy28 partially prevents apoptosis induction following engagement of membrane immunoglobulin in WEHI-231 B lymphoma cells

J. Mizuguchi, H. Toyota, H. Asakura, 2011, Cellular & Molecular Biology Letters.

Apoptosis signal-regulating kinase (ASK)-1 mediates apoptosis through activation of JNK1 following engagement of membrane immunoglobulin.

H. Ichijo, J. Mizuguchi, E. Takada, 2009, Experimental cell research.

Apoptosis induced by chemotherapeutic agents involves c‐Jun N‐terminal kinase activation in sarcoma cell lines

T. Mikami, J. Mizuguchi, A. Imakiire, 2006, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Requirement of c-Jun NH2-terminal kinase activation in interferon-alpha-induced apoptosis through upregulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in Daudi B lymphoma cells.

B. Evers, J. Mizuguchi, N. Yanase, 2005, Experimental cell research.

Interferon-β-induced activation of c-Jun NH2-terminal kinase mediates apoptosis through up-regulation of CD95 in CH31 B lymphoma cells

L. Heasley, J. Mizuguchi, M. Moriyama, 2005 .

Requirement for JNK1 in OVA-induced Airway Hyperresponsiveness in vivo

K. Sudo, J. Mizuguchi, E. Takada, 2015 .

Enhanced T cell-independent antibody responses in c-Jun N-terminal kinase 2 (JNK2)-deficient B cells following stimulation with CpG-1826 and anti-IgM.

K. Sudo, J. Mizuguchi, E. Takada, 2010, Immunology letters.

Requirement of c-Jun N terminal kinase and P38 mitogen-activated protein kinase for anti-IgM-induced reduction in mitochondrial membrane potential in CH31 B lymphoma cells.

J. Mizuguchi, E. Takada, H. Toyota, 2002, Immunology letters.

Regulation of the development of acute hepatitis by IL‐23 through IL‐22 and IL‐17 production

Y. Iwakura, M. Kuroda, T. Yoshimoto, 2011, European journal of immunology.

IL-27 Induces Th1 Differentiation via p38 MAPK/T-bet- and Intercellular Adhesion Molecule-1/LFA-1/ERK1/2-Dependent Pathways1

T. Yoshimoto, J. Mizuguchi, T. Owaki, 2006, The Journal of Immunology.

Pathways Molecule-1 / LFA-1 / ERK 1 / 2-Dependent MAPK / T-bet-and Intercellular Adhesion IL-27 Induces Th 1 Differentiation via p 38

T. Yoshimoto, J. Mizuguchi, T. Owaki, 2006 .

Regulation of Antitumor Immune Responses by the IL-12 Family Cytokines, IL-12, IL-23, and IL-27

T. Yoshimoto, J. Mizuguchi, N. Morishima, 2010, Clinical & developmental immunology.

A Pivotal Role for Interleukin-27 in CD8+ T Cell Functions and Generation of Cytotoxic T Lymphocytes

T. Yoshimoto, J. Mizuguchi, N. Morishima, 2010, Journal of biomedicine & biotechnology.

Interleukins and cancer immunotherapy.

T. Yoshimoto, J. Mizuguchi, N. Morishima, 2009, Immunotherapy.

Kinetics of intraocular cytokines in the suppression of experimental autoimmune uveoretinitis by type I IFN.

J. Mizuguchi, J. Sakai, A. Okada, 1998, International immunology.

Mitochondrial depolarization and apoptosis associated with sustained activation of c-jun-N-terminal kinasein the human multiple myeloma cell line U266 induced by 2-aminophenoxazine-3-one.

H. Hanyu, T. Iwamoto, K. Shirato, 2009, Molecular medicine reports.

Tumor necrosis factor-related apoptosis-inducing ligand induces apoptotic cell death through c-Jun NH 2-terminal kinase activation in squamous cell carcinoma cells

J. Mizuguchi, E. Takada, H. Toyota, 2022 .

An Indispensable Role for STAT1 in IL-27-Induced T-bet Expression but Not Proliferation of Naive CD4+ T Cells1

T. Yoshimoto, J. Mizuguchi, T. Owaki, 2004, The Journal of Immunology.

A Role for IL-27 in Early Regulation of Th1 Differentiation1

T. Yoshimoto, J. Mizuguchi, T. Owaki, 2005, The Journal of Immunology.

Induction of IgG2a Class Switching in B Cells by IL-271

Y. Iwakura, T. Yoshimoto, J. Mizuguchi, 2004, The Journal of Immunology.

Antiangiogenic and Antitumor Activities of IL-271

M. Kudo, Y. Iwakura, A. Luster, 2006, The Journal of Immunology.

IL-27 Antiangiogenic and Antitumor Activities of Mizuguchi and Takayuki Yoshimoto Iwakura

M. Kudo, Y. Iwakura, A. Luster, 2006 .

Proliferation of Naive CD 4 IL-27-Induced T-bet Expression but Not An Indispensable Role for STAT 1 in

T. Yoshimoto, J. Mizuguchi, T. Owaki, 2004 .

Differentiation A Role for IL-27 in Early Regulation of Th 1 Mizuguchi and Takayuki Yoshimoto

T. Yoshimoto, J. Mizuguchi, T. Owaki, 2022 .

Promotion of Expansion and Differentiation of Hematopoietic Stem Cells by Interleukin-27 into Myeloid Progenitors to Control Infection in Emergency Myelopoiesis

S. Nakae, Tetsuya Matsumoto, T. Yoshimoto, 2016, PLoS pathogens.

Anti-IgM-induced down-regulation of nuclear Thy28 protein expression in Ramos B lymphoma cells

T. Yoshimoto, J. Mizuguchi, E. Takada, 2003, Apoptosis.

Molecular events in the induction of a nonresponsive state in interleukin 2-producing helper T-lymphocyte clones.

R. Schwartz, D. Pardoll, M. Jenkins, 1987, Proceedings of the National Academy of Sciences of the United States of America.

A selective signaling defect in helper T cells induced by antigen-presenting cells from mice with murine acquired immunodeficiency syndrome.

Y. Asano, H. Morse, M. Nakanishi, 1990, Journal of immunology.

c‐Jun NH2‐terminal kinase (JNK)‐dependent nuclear translocation of apoptosis‐inducing factor (AIF) following engagement of membrane immunoglobulin on WEHI‐231 B lymphoma cells

J. Mizuguchi, E. Takada, Kikumi Hata, 2008, Journal of cellular biochemistry.

INVOLVEMENT OF TRAIL/TRAIL-R INTERACTION IN IFN-α-INDUCED APOPTOSIS OF DAUDI B LYMPHOMA CELLS

C. Ibukiyama, J. Mizuguchi, A. Yamashina, 2001 .

Epigenetic reprogramming in regulatory elements

R. Eils, S. Wiemann, C. Plass, 2017 .

Crystal Structure of Thrombin in Complex with S-Variegin: Insights of a Novel Mechanism of Inhibition and Design of Tunable Thrombin Inhibitors

R. Kini, C. Koh, K. Swaminathan, 2011, PloS one.

BSF-1 action on resting B cells does not require elevation of inositol phospholipid metabolism or increased [Ca2+]i.

W. Paul, J. Mizuguchi, M. Beaven, 1986, Journal of immunology.

Cerivastatin-induced apoptosis of human aortic smooth muscle cells through partial inhibition of basal activation of extracellular signal-regulated kinases.

J. Mizuguchi, A. Yamashina, H. Nakajima, 2004, Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology.

Vaccination with OVA-bound nanoparticles encapsulating IL-7 inhibits the growth of OVA-expressing E.G7 tumor cells in vivo.

T. Yoshimoto, J. Mizuguchi, N. Yanase, 2015, Oncology reports.

Crystal Structures of Soluble Tissue Factor and Factor VIIa-Tissue Factor Complex

J. Mizuguchi, S. Iwanaga, K. Soejima, 1999 .

Immunopotentiative effect of polysaccharide from kefir grain, KGF-C, administered orally in mice.

J. Mizuguchi, K. Aibara, T. Matuhasi, 1986, Immunopharmacology.

Different effect of LPS-induced macrophage factor on antibody responses to TI-1 and TI-2 antigens.

H. Nariuchi, J. Mizuguchi, T. Kakiuchi, 1982, Immunology.

Establishment of T-cell hybridoma constitutively producing macrophage-dependent T-cell replacing factor.

H. Nariuchi, J. Mizuguchi, T. Kakiuchi, 1986, Cellular immunology.

Thy28 protects against anti-CD3-mediated thymic cell death in vivo

K. Sudo, J. Mizuguchi, T. Kakiuchi, 2015, Apoptosis.

Interferon-alpha-induced apoptosis via tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-dependent and -independent manner.

J. Mizuguchi, N. Yanase, Y. Kanetaka, 2007, Oncology reports.

IFN-α Sensitizes Daudi B Lymphoma Cells to Anti-IgMInduced Loss of Mitochondrial Membrane Potential Through Activation of c-Jun NH2-Terminal Kinase

J. Mizuguchi, N. Yanase, A. Hoshika, 2006 .

Requirement of Apoptosis-Inducing Kinase 1 for the Induction of Bronchial Asthma following Stimulation with Ovalbumin

S. Nakae, H. Ichijo, K. Sudo, 2013, International Archives of Allergy and Immunology.

Combined stimulation with interferon α and retinoic acid synergistically inhibits proliferation of the glioblastoma cell line GB12

T. Nishi, Hiroshi Ito, J. Mizuguchi, 2002, Neurological research.

Ovalbumin coupled either with murine red blood cells or liposome induces IgG but not IgE antibody production.

J. Mizuguchi, M. Taneichi, T. Uchida, 1998, Developments in biological standardization.

Requirement of at least two distinct monoclonal antibodies for efficient neutralization of tetanus toxin in vivo

J. Mizuguchi, Y. Sato, T. Yoshida, 1982, Naturwissenschaften.

von Willebrand Factor Deficient Mice

J. Mizuguchi, K. Tomokiyo, H. Yano, 1999 .

PKC-δ mediates interferon-α-induced apoptosis through c-Jun NH2-terminal kinase activation

J. Mizuguchi, N. Yanase, A. Hoshika, 2012, BMC Cell Biology.

Cytochrome c release, mitochondrial membrane depolarization, caspase-3 activation, and Bax-alpha cleavage during IFN-alpha-induced apoptosis in Daudi B lymphoma cells.

J. Mizuguchi, N. Yanase, H. Ikegami, 2000, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Participation of Bax-alpha in IFN-alpha-mediated apoptosis in Daudi B lymphoma cells.

J. Mizuguchi, E. Takada, I. Yoshihama, 1998, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Thy28 partially prevents apoptosis induction following engagement of membrane immunoglobulin in WEHI-231 B lymphoma cells

J. Mizuguchi, H. Toyota, H. Asakura, 2011, Cellular & Molecular Biology Letters.

Protein C Deficient Mice

J. Mizuguchi, T. Hamamoto, Katsuro Shimose, 1999 .

Comparison of the calcium requirement for the induction and maintenance of B cell class II molecule expression and for B cell proliferation stimulated by mitogens and purified growth factors.

F. Finkelman, J. Mizuguchi, J. Ohara, 1987, Journal of immunology.

Induction of differential T-cell epitope by plain- and liposome-coupled antigen.

Mitsuhiro Nishida, J. Mizuguchi, Yuriko Tanaka, 2006, Bioconjugate chemistry.

Targeted Inactivation of the Mouse α2-Macroglobulin Gene

J. Mizuguchi, T. Nakagaki, K. Kamimura, 1998 .

Retrovirus-mediated transduction of TRAIL and chemotherapeutic agents co-operatively induce apoptotic cell death in both sarcoma and myeloma cells.

T. Yoshimoto, J. Mizuguchi, T. Koyama, 2003, Anticancer research.

Regulation of inflammatory immune responses leading to the development of bone destructive autoimmune disease rheumatoid arthritis by IL-27

T. Yoshimoto, J. Mizuguchi, S. Shahrara, 2012, Arthritis Research & Therapy.

Molecular analysis of the dissociation between IL-2 production and proliferation in a response of a T cell clone to the antigen presented by B cells.

H. Nariuchi, J. Mizuguchi, T. Kakiuchi, 1988, Journal of immunology.

Title Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity

Tybulewicz, J. Mizuguchi, I. Kawamura, 2016 .

Thrombospondins Deficient Mice

J. Mizuguchi, H. Kaetsu, K. Kamimura, 1999 .

Phosphorylation of ASC acts as a molecular switch controlling the formation of speck-like aggregates and inflammasome activity

V. Tybulewicz, J. Mizuguchi, I. Kawamura, 2013, Nature Immunology.

Phosphorylation of ASC acts as a molecular switch controlling the formation of speck-like aggregates and inflammasome activity

V. Tybulewicz, J. Mizuguchi, I. Kawamura, 2016 .

Oral administration of interferon-β suppresses experimental autoimmune uveoretinitis

J. Mizuguchi, J. Sakai, A. Okada, 2002, Graefe's Archive for Clinical and Experimental Ophthalmology.

A double-edged sword in B-cell-targeted therapy for inflammatory diseases

J. Mizuguchi, 2009, Expert review of clinical immunology.

Differential responses of p56lyn and p53lyn, products of alternatively spliced lyn mRNA, on stimulation of B-cell antigen receptor.

J. Mizuguchi, Y. Yamanashi, M. Takeuchi, 1991, Cell Regulation.