H. Kamiya

发表

Visualization of intracellular trafficking of exogenous DNA delivered by cationic liposomes.

H. Harashima, H. Kamiya, Y. Fujimura, 2002, Biochemical and biophysical research communications.

Cell cycle dependent transcription, a determinant factor of heterogeneity in cationic lipid‐mediated transgene expression

Hideyoshi Harashima, Hiroyuki Kamiya, Hidetaka Akita, 2007, The journal of gene medicine.

Pharmacokinetic and pharmacodynamic considerations in gene therapy.

Hideyoshi Harashima, Hiroyuki Kamiya, Hidetaka Akita, 2003, Drug discovery today.

No enhancement of nuclear entry by direct conjugation of a nuclear localization signal peptide to linearized DNA.

N. Minakawa, A. Matsuda, H. Harashima, 2003, Bioconjugate chemistry.

Synthesis of a Phosphoramidite Coupling Unit of the Pyrimidine (6−4) Pyrimidone Photoproduct and Its Incorporation into Oligodeoxynucleotides

E. Ohtsuka, S. Iwai, H. Kamiya, 1996 .

Methylglyoxal, an endogenous aldehyde, crosslinks DNA polymerase and the substrate DNA.

H. Kamiya, N. Murata‐Kamiya, 2001, Nucleic acids research.

Induction of transition and transversion mutations during random mutagenesis PCR by the addition of 2-hydroxy-dATP.

H. Harashima, H. Kamiya, Mana Ito, 2004, Biological & pharmaceutical bulletin.

Induction of various mutations during PCRs with manganese and 8-hydroxy-dGTP.

H. Harashima, H. Kamiya, Mana Ito, 2007, Biological & pharmaceutical bulletin.

Kinetic analysis of protein production after DNA transfection.

H. Harashima, Yuma Yamada, H. Kamiya, 2005, International journal of pharmaceutics.

Suppression of mutagenesis by 8-hydroxy-2'-deoxyguanosine 5'-triphosphate (7,8-dihydro-8-oxo-2'-deoxyguanosine 5'-triphosphate) by human MTH1, MTH2, and NUDT5.

H. Harashima, H. Kamiya, M. Hori, 2010, Free radical biology & medicine.

PK-PD modeling of 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine and the enhanced antitumor effect of its phospholipid derivatives in long-circulating liposomes.

S. Shuto, A. Matsuda, H. Harashima, 2009, International journal of pharmaceutics.

Transcription of 4'-thioDNA templates to natural RNA in vitro and in mammalian cells.

N. Minakawa, A. Matsuda, H. Kamiya, 2015, Chemical communications.

High-throughput analysis of DNA repair in microplates towards identification of inhibitors

H. Kamiya, 2020, Genes and Environment.

Mutations induced by 2-hydroxyadenine on a shuttle vector during leading and lagging strand syntheses in mammalian cells.

H. Kamiya, H. Kasai, 1997, Biochemistry.

Human MTH3 (NUDT18) Protein Hydrolyzes Oxidized Forms of Guanosine and Deoxyguanosine Diphosphates

Y. Yamagata, M. Sekiguchi, H. Kamiya, 2012, The Journal of Biological Chemistry.

Synthesis and Thermodynamic Stabilities of Damaged DNA Involving 8-Hydroxyguanine (7,8-Dihydro-8-Oxoguanine) in a ras-Gene Fragments

E. Ohtsuka, H. Kamiya, H. Inoue, 1994 .

8-Hydroxydeoxyguanosine, a DNA Adduct Formed by Oxygen Radicals: Its Implications on the Mutagenic and Carcinogenic Action of Oxygen Radical-Forming Agents

M. Chung, E. Ohtsuka, H. Kamiya, 1991 .

Effects of carriers on transgene expression from plasmids containing a DNA sequence with high histone affinity.

H. Harashima, H. Kamiya, T. Ohyama, 2009, International journal of pharmaceutics.

Increased SFHR gene correction efficiency with sense single‐stranded DNA

Hideyoshi Harashima, Hiroyuki Kamiya, Hiroyuki Tsuchiya, 2005, The journal of gene medicine.

Effects of target sequence and sense versus anti-sense strands on gene correction with single-stranded DNA fragments.

Y. Nakatsu, T. Tsuzuki, H. Harashima, 2008, Journal of biochemistry.

Effects of 8-hydroxy-GTP and 2-hydroxy-ATP on in vitro transcription.

H. Harashima, H. Kamiya, A. Suzuki, 2007, Free radical biology & medicine.

Transient Expression of Drosophila melanogaster Deoxynucleoside Kinase Gene Enhances Cytotoxicity of Nucleoside Analogs

A. Matsuda, H. Ochiai, H. Harashima, 2006, Nucleosides, nucleotides & nucleic acids.

Suppression of Short Tract Gene Conversion in Episomal DNA by p53 Reduction

H. Harashima, H. Kamiya, Tetsuya Suzuki, 2014 .

Transformation of NIH3T3 Cells with Synthetic c‐Ha‐ras Genes

E. Ohtsuka, H. Kamiya, S. Nishimura, 1989, Japanese journal of cancer research : Gann.

An oxidized nucleotide affects DNA replication through activation of protein kinases in Xenopus egg lysates.

H. Kamiya, Motoshi Suzuki, S. Izuta, 2002, Nucleic acids research.

Calpain 10 as a predictive gene for type 2 diabetes: evidence from a novel screening system using white blood cells of Otsuka Long-Evans Tokushima Fatty (OLETF) rats.

H. Harashima, H. Kamiya, Yuichiro Sato, 2003, Biological & pharmaceutical bulletin.

Correction of monomeric enhanced green fluorescent protein (mEGFP) gene by short 5'-tailed duplexes.

H. Kawai, H. Kamiya, Ryotaro Kamitsubo, 2022, Journal of bioscience and bioengineering.

8-Hydroxyguanine, a DNA adduct formed by oxygen radicals: its implication on oxygen radical-involved mutagenesis/carcinogenesis.

M. Chung, E. Ohtsuka, H. Kamiya, 1991, The Journal of toxicological sciences.

Unexpectedly Weak Impacts of Decreased p53 and Retinoblastoma Protein Levels on Mutagenesis by 8-Oxo-7,8-dihydroguanine (8-Hydroxyguanine)

H. Harashima, H. Kamiya, Tetsuya Suzuki, 2011 .

Conventional plasmid DNAs with a CpG‐containing backbone achieve durable transgene expression in mouse liver

H. Kamiya, Tetsuya Suzuki, Yusuke Wakao, 2019, The journal of gene medicine.

NUDT5 hydrolyzes oxidized deoxyribonucleoside diphosphates with broad substrate specificity.

Y. Yamagata, M. Sekiguchi, H. Harashima, 2009, DNA repair.

Incorporation of 8-hydroxyguanosine (8-oxo-7,8-dihydroguanosine) 5'-triphosphate by bacterial and human RNA polymerases

H. Handa, Y. Yamaguchi, H. Harashima, 2018 .

Correlation between the Phosphohydrolase Activity of the Escherichia coli Orf135 (NudG) Protein and Mutation Suppression

H. Harashima, H. Kamiya, E. Iida, 2007 .

Recognition of nucleotide analogs containing the 7,8-dihydro-8-oxo structure by the human MTH1 protein.

N. Minakawa, A. Matsuda, S. Pochet, 2006, Journal of biochemistry.

Induction of Substitution and Deletion Mutations by 2-Hydroxyadenine during Replication in a HeLa Extract

H. Harashima, H. Kamiya, H. Kasai, 2006 .

Probing the substrate recognition mechanism of the human MTH1 protein by nucleotide analogs.

S. Pochet, L. Dugué, Y. Nakabeppu, 2004, Journal of molecular biology.

Mutagenic effects of 2-hydroxy-dATP on replication in a HeLa extract: induction of substitution and deletion mutations.

H. Harashima, H. Kamiya, Kazuya Satou, 2003, Nucleic acids research.

Hydrolysis of oxidized nucleotides by the Escherichia coli Orf135 protein.

H. Harashima, H. Kamiya, N. Murata‐Kamiya, 2001, Biochemical and biophysical research communications.

Comparison of Oxidation Products from DNA Components by γ-Irradiation and Fenton-Type Reactions

H. Kamiya, N. Murata‐Kamiya, H. Kasai, 1997 .

Comparison of Incorporation and Extension of Nucleotides in vitro opposite 8‐Hydroxyguanine (7,8‐Dihydro‐8‐oxoguanine) in Hot Spots of the c‐Ha‐ras Gene

M. Fujimuro, F. Hanaoka, E. Ohtsuka, 1995, Japanese journal of cancer research : Gann.

c-Ha-ras down regulates the alpha-fetoprotein gene but not the albumin gene in human hepatoma cells

E. Ohtsuka, H. Nakabayashi, H. Kamiya, 1990, Molecular and cellular biology.

8-Hydroxyguanine (7,8-dihydro-8-oxoguanine) in hot spots of the c-Ha-ras gene: effects of sequence contexts on mutation spectra.

E. Ohtsuka, H. Kamiya, N. Murata‐Kamiya, 1995, Carcinogenesis.

A Simple, General Method for Detecting Retroviral RNAs Expressed in Cells

Takuma Sasaki, H. Kamiya, Y. Hirose, 1990, Japanese journal of cancer research : Gann.

In vivo mutagenicities of damaged nucleotides produced by nitric oxide and ionizing radiation.

H. Harashima, H. Kamiya, M. Hori, 2005, Biological & pharmaceutical bulletin.

8-Hydroxyadenine (7,8-dihydro-8-oxoadenine) induces misincorporation in in vitro DNA synthesis and mutations in NIH 3T3 cells.

F. Hanaoka, H. Kamiya, C. Masutani, 1995, Nucleic acids research.

Reduced plasma glucose by asparagine synthetase knockdown in the mouse liver.

N. Kaji, Y. Baba, H. Harashima, 2013, Biological & pharmaceutical bulletin.

Development of a versatile high-throughput mutagenesis assay with multiplexed short read NGS using DNA-barcoded supF shuttle vector library amplified in non-SOS E. coli

H. Kawai, H. Kamiya, Shogo Masuda, 2022, bioRxiv.

Nucleotide excision repair proteins may be involved in the fixation of glyoxal-induced mutagenesis in Escherichia coli.

H. Kamiya, N. Murata‐Kamiya, H. Kasai, 1998, Biochemical and biophysical research communications.

Size and topology of exogenous DNA as determinant factors of transgene transcription in mammalian cells

H. Harashima, H. Kamiya, J. Yamazaki, 2002, Gene Therapy.

Cytokine induction by a bacterial DNA-specific modified base.

T. Matsuda, H. Harashima, H. Kamiya, 2005, Biochemical and biophysical research communications.

Durable Transgene Expression Driven by CpG-Free and -Containing Promoters in Plasmid DNA with CpG-Free Backbone.

H. Kamiya, Tetsuya Suzuki, Takuya Goda, 2018, Biological & pharmaceutical bulletin.

Nucleotide Incorporation Opposite Degenerate Bases by Taq DNA Polymerase

E. Ohtsuka, H. Kamiya, N. Murata‐Kamiya, 1994 .

Mutation induced by deoxyxanthosine in codon 12 of a synthetic c-Ha-ras gene.

E. Ohtsuka, H. Kamiya, H. Inoue, 1992, Nucleosides & nucleotides.

Leading versus lagging strand mutagenesis induced by 7,8-dihydro-8-oxo-2'-deoxyguanosine in Escherichia coli.

J. Wagner, R. Fuchs, H. Kamiya, 1997, Journal of molecular biology.

Biased distribution of action-at-a-distance mutations by 8-oxo-7,8-dihydroguanine.

Y. Komatsu, H. Kamiya, Tetsuya Suzuki, 2022, Mutation research.

Development of a versatile high-throughput mutagenesis assay with multiplexed short-read NGS using DNA-barcoded supF shuttle vector library amplified in E. coli

H. Kawai, H. Kamiya, Shogo Masuda, 2022, bioRxiv.

An abasic site analogue activates a c-Ha-ras gene by a point mutation at modified and adjacent positions.

Y. Komatsu, F. Hanaoka, E. Ohtsuka, 1992, Nucleic acids research.

Tyrosyl-DNA phosphodiesterases are involved in mutagenic events at a ribonucleotide embedded into DNA in human cells

K. Sugasawa, M. Honma, H. Kamiya, 2020, PloS one.

Crystallization and preliminary X-ray analysis of human MTH1 complexed with two oxidized nucleotides, 8-oxo-dGMP and 2-oxo-dATP.

M. Shirakawa, Teruya Nakamura, Y. Yamagata, 2006, Acta crystallographica. Section F, Structural biology and crystallization communications.

CREB-binding protein transcription activation domain for enhanced transgene expression by a positive feedback system.

Genki N. Kanda, H. Ochiai, H. Harashima, 2012, Journal of biotechnology.

Effects of sequence contexts on misincorporation of nucleotides opposite 2‐hydroxyadenine

H. Kamiya, H. Kasai, 1996, FEBS letters.

Effects of endogenous proteins and microRNA target sequence in a positive feedback system.

Genki N. Kanda, H. Harashima, H. Kamiya, 2012, Biological & pharmaceutical bulletin.

triphosphate ) by human MTH 1 , MTH 2 , and NUDT 5

H. Harashima, H. Kamiya, M. Hori, 2017 .

Easily-controllable, helper phage-free single-stranded phagemid production system

H. Kamiya, Tetsuya Suzuki, 2022, Genes and Environment.

New indicator Escherichia coli strain for rapid and accurate detection of supF mutations

H. Kamiya, Tetsuya Suzuki, R. Fukushima, 2020, Genes and environment : the official journal of the Japanese Environmental Mutagen Society.

Formation of a mutagen, glyoxal, from DNA treated with oxygen free radicals.

H. Kamiya, N. Murata‐Kamiya, H. Kasai, 1995, Carcinogenesis.

Methylglyoxal induces G:C to C:G and G:C to T:A transversions in the supF gene on a shuttle vector plasmid replicated in mammalian cells.

H. Kamiya, N. Murata‐Kamiya, H. Kasai, 2000, Mutation research.

Induction of T --> G and T --> A transversions by 5-formyluracil in mammalian cells.

A. Matsuda, H. Kamiya, N. Murata‐Kamiya, 2002, Mutation research.

Misincorporation of dAMP opposite 2-hydroxyadenine, an oxidative form of adenine.

A. Matsukage, H. Kamiya, T. Ohgi, 1995, Nucleic acids research.

Formation of 5-formyl-2'-deoxycytidine from 5-methyl-2'-deoxycytidine in duplex DNA by Fenton-type reactions and gamma-irradiation.

A. Matsuda, H. Kamiya, N. Murata‐Kamiya, 1999, Nucleic acids research.

Mitochondrial drug delivery and mitochondrial disease therapy--an approach to liposome-based delivery targeted to mitochondria.

Yuma Yamada, Hideyoshi Harashima, Hiroyuki Kamiya, 2007, Mitochondrion.

New NTP analogs: the synthesis of 4′-thioUTP and 4′-thioCTP and their utility for SELEX

Y. Komatsu, N. Minakawa, A. Matsuda, 2005, Nucleic acids research.

Intracellular trafficking and transgene expression of viral and non-viral gene vectors.

H. Harashima, H. Kamiya, H. Tsuchiya, 2001, Advanced drug delivery reviews.

In vivo selection of active deoxyribonucleoside kinase by a mutagenic nucleoside analog.

H. Harashima, H. Kamiya, K. Nishi, 2016, Journal of biotechnology.

Nucleosides and nucleotides. Part 226: alternate-strand triple-helix formation by 3'-3'-linked oligodeoxynucleotides composed of asymmetrical sequences.

A. Matsuda, H. Kamiya, S. Hoshika, 2004, Bioorganic & medicinal chemistry letters.

Ribozymes designed to inhibit transformation of NIH3T3 cells by the activated c-Ha-ras gene.

E. Ohtsuka, H. Kamiya, M. Koizumi, 1992, Gene.

In vitro replication study of modified bases in ras sequences.

M. Fujimuro, A. Matsukage, H. Kamiya, 1992, Chemical & pharmaceutical bulletin.

The mutations induced by oxidatively damaged nucleotides, 5-formyl-dUTP and 5-hydroxy-dCTP,in Escherichia coli.

H. Kamiya, H. Kasai, K. Fujikawa, 1998, Nucleic acids research.

Mutation‐spectrum of a true abasic site in codon 12 of a c‐Ha‐ras gene in mammalian cells

E. Ohtsuka, H. Kamiya, Masayuki Suzuki, 1993, FEBS letters.

c-Ha-ras containing 8-hydroxyguanine at codon 12 induces point mutations at the modified and adjacent positions.

E. Ohtsuka, H. Kamiya, S. Nishimura, 1992, Cancer research.

Involvement of Y-Family DNA Polymerases in Mutagenesis Caused by Oxidized Nucleotides in Escherichia coli

M. Yamada, T. Nunoshiba, H. Harashima, 2006, Journal of bacteriology.

Formation of 2-Hydroxydeoxyadenosine Triphosphate, an Oxidatively Damaged Nucleotide, and Its Incorporation by DNA Polymerases

H. Kamiya, H. Kasai, 1995, The Journal of Biological Chemistry.

Thermodynamic stability of base pairs between 2-hydroxyadenine and incoming nucleotides as a determinant of nucleotide incorporation specificity during replication.

N. Sugimoto, J. Kawakami, H. Kamiya, 2001, Nucleic acids research.

Mutagenic potentials of damaged nucleic acids produced by reactive oxygen/nitrogen species: approaches using synthetic oligonucleotides and nucleotides: survey and summary.

H. Kamiya, 2003, Nucleic acids research.

Induction of mutation of a synthetic c-Ha-ras gene containing hypoxanthine.

E. Ohtsuka, H. Kamiya, S. Nishimura, 1992, Cancer research.

Mutagenicity of oxidized DNA precursors in living cells: Roles of nucleotide pool sanitization and DNA repair enzymes, and translesion synthesis DNA polymerases.

Hiroyuki Kamiya, H. Kamiya, 2010, Mutation research.

PREPARATION OF 8-HYDROXY-DGTP AND 2-HYDROXY-DATP BY A PHOSPHATE TRANSFER REACTION BY NUCLEOSIDE-DIPHOSPHATE KINASE

H. Kamiya, H. Kasai, 1999 .

Pharmacokinetic modeling of species-dependent enhanced bioavailability of trifluorothymidine by thymidine phosphorylase inhibitor.

H. Harashima, H. Kamiya, S. Nagayama, 2004, Drug metabolism and pharmacokinetics.

Transferrin-modified liposomes equipped with a pH-sensitive fusogenic peptide: an artificial viral-like delivery system.

Kazuo Maruyama, Shiroh Futaki, Hideyoshi Harashima, 2004, Biochemistry.

Mutations induced by 8-hydroxyguanine (8-oxo-7,8-dihydroguanine), a representative oxidized base, in mammalian cells

H. Kamiya, Tetsuya Suzuki, 2016, Genes and Environment.

DNA Polymerase λ Promotes Mutagenesis Induced by 8-Oxo-7, 8-dihydroguanine(8-hydroxyguanine)Paired with Adenine

H. Kamiya, M. Kurokawa, 2013 .

Roles of specialized DNA polymerases in mutagenesis by 8-hydroxyguanine in human cells.

H. Harashima, H. Kamiya, Tetsuya Suzuki, 2010, Mutation research.

Mutagenicities of 8-hydroxyguanine and 2-hydroxyadenine produced by reactive oxygen species.

H. Kamiya, 2004, Biological & pharmaceutical bulletin.

Cytotoxic effect of Drosophila deoxynucleoside kinase gene on replicating plasmid in HeLa cells.

H. Harashima, H. Kamiya, Mana Ito, 2010, Biological & pharmaceutical bulletin.

Suppression of spontaneous and hydrogen peroxide‐induced mutations by a MutT‐type nucleotide pool sanitization enzyme, the Escherichia coli Orf135 protein

Yoshihiro Yamamoto, H. Harashima, H. Kamiya, 2003, Genes to cells : devoted to molecular & cellular mechanisms.

Induction of Chromosomal Gene Mutations in Escherichia coli by Direct Incorporation of Oxidatively Damaged Nucleotides

K. Yasumoto, H. Kamiya, N. Murata‐Kamiya, 1998, The Journal of Biological Chemistry.

Mitochondrial delivery of mastoparan with transferrin liposomes equipped with a pH-sensitive fusogenic peptide for selective cancer therapy.

Yasuo Shinohara, Yuma Yamada, Shiroh Futaki, 2005, International journal of pharmaceutics.

Insights into substrate recognition by the Escherichia coli Orf135 protein through its solution structure.

C. Kojima, H. Kamiya, N. Murata‐Kamiya, 2012, Biochemical and biophysical research communications.

Mutagenicity of secondary oxidation products of 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate (8-hydroxy-2'- deoxyguanosine 5'-triphosphate).

N. Minakawa, A. Matsuda, H. Harashima, 2011, Mutation research.

Effects of base excision repair proteins on mutagenesis by 8-oxo-7,8-dihydroguanine (8-hydroxyguanine) paired with cytosine and adenine.

H. Harashima, H. Kamiya, Tetsuya Suzuki, 2010, DNA repair.

Involvement of specialized DNA polymerases in mutagenesis by 8-hydroxy-dGTP in human cells.

H. Harashima, H. Kamiya, H. Kasai, 2009, DNA repair.

Specificity of mutations induced by incorporation of oxidized dNTPs into DNA by human DNA polymerase eta.

M. Yamada, F. Hanaoka, H. Harashima, 2008, DNA repair.

Base excision repair enzyme endonuclease III suppresses mutagenesis caused by 8-hydroxy-dGTP.

H. Harashima, H. Kamiya, Tetsuya Suzuki, 2008, DNA repair.

UvrA and UvrB enhance mutations induced by oxidized deoxyribonucleotides.

S. Kuramitsu, T. Nunoshiba, H. Harashima, 2007, DNA repair.

Mutations Induced by Oxidized DNA Precursors and Their Prevention by Nucleotide Pool Sanitization Enzymes

H. Kamiya, 2007 .

Mutagenic effects of 8-hydroxy-dGTP in live mammalian cells.

H. Harashima, H. Kamiya, H. Kasai, 2007, Free radical biology & medicine.

Effects of overexpression and antisense RNA expression of Orf17, a MutT-type enzyme.

O. Inanami, M. Kuwabara, T. Asanuma, 2006, Biological & pharmaceutical bulletin.

Structure of Human MTH1, a Nudix Family Hydrolase That Selectively Degrades Oxidized Purine Nucleoside Triphosphates*

M. Shirakawa, Y. Yamagata, M. Furuichi, 2004, Journal of Biological Chemistry.

Erroneous incorporation of oxidized DNA precursors by Y‐family DNA polymerases

F. Hanaoka, Y. Kanke, H. Harashima, 2003, EMBO reports.

Arg660Ser mutation in Thermus aquaticus DNA polymerase I suppresses T-->C transitions: implication of wobble base pair formation at the nucleotide incorporation step.

S. Yoshida, M. Ogawa, H. Kamiya, 2001, Nucleic acids research.

Human MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATP.

H. Kamiya, H. Kasai, H. Yakushiji, 2001, Nucleic acids research.

2-hydroxyadenine in DNA is a very poor substrate of the Escherichia coli MutY protein.

H. Kamiya, H. Kasai, 2000, Journal of radiation research.

The Oxidized Forms of dATP Are Substrates for the Human MutT Homologue, the hMTH1 Protein*

Y. Nakabeppu, H. Kamiya, H. Kasai, 1999, The Journal of Biological Chemistry.

Mutational specificity of glyoxal, a product of DNA oxidation, in the lacI gene of wild-type Escherichia coli W3110.

H. Kamiya, N. Murata‐Kamiya, H. Kasai, 1997, Mutation research.

Substitution and deletion mutations induced by 2-hydroxyadenine in Escherichia coli: effects of sequence contexts in leading and lagging strands.

H. Kamiya, H. Kasai, 1997, Nucleic acids research.

MITO-Porter: A liposome-based carrier system for delivery of macromolecules into mitochondria via membrane fusion.

Takenori Yamamoto, Y. Shinohara, K. Kogure, 2008, Biochimica et biophysica acta.

RNA interference induced by siRNAs modified with 4′‐thioribonucleosides in cultured mammalian cells

Hideyoshi Harashima, Shuichi Hoshika, Hiroyuki Kamiya, 2005, FEBS letters.

Diverse substrate recognition and hydrolysis mechanisms of human NUDT5

Teruya Nakamura, Y. Yamagata, M. Sekiguchi, 2011, Nucleic acids research.

Characterization of a Nudix hydrolase from Deinococcus radiodurans with a marked specificity for (deoxy)ribonucleoside 5'-diphosphates

A. McLennan, H. Harashima, David I. Fisher, 2004, BMC Biochemistry.

Transforming Activity of a Synthetic c‐Ha‐ras Gene Containing O6‐Methylguanine in Codon 12

E. Ohtsuka, H. Kamiya, S. Nishimura, 1991, Japanese journal of cancer research : Gann.

Gene correction by 5'-tailed duplexes with short editor oligodeoxyribonucleotides.

H. Kawai, H. Kamiya, Ryotaro Kamitsubo, 2021, Journal of bioscience and bioengineering.

Large deletions and untargeted substitutions induced by abasic site analog on leading versus lagging strand templates in human cells.

Y. Komatsu, H. Kamiya, Tetsuya Suzuki, 2019, Mutagenesis.

Analysis of large deletion mutations induced by abasic site analog in human cells

Y. Komatsu, H. Kamiya, Tetsuya Suzuki, 2018, Genes and Environment.

Induction of action-at-a-distance mutagenesis by 8-oxo-7,8-dihydroguanine in DNA pol λ-knockdown cells

H. Kamiya, I. Matsuoka, Miwako Kobayashi, 2015, Genes and Environment.

Mutagenic bypass of 8-oxo-7,8-dihydroguanine (8-hydroxyguanine) by DNA polymerase κ in human cells.

H. Kamiya, M. Kurokawa, 2012, Chemical Research in Toxicology.

Mutations induced by 8-oxo-7,8-dihydroguanine in WRN- and DNA polymerase &lgr;-double knockdown cells

H. Kamiya, I. Matsuoka, Tetsuya Suzuki, 2018, Mutagenesis.

Neighboring base damage induced by permanganate oxidation of 8-oxoguanine in DNA.

E. Ohtsuka, H. Kamiya, H. Inoue, 1998, Nucleic acids research.

Paradoxical role of the major DNA repair protein, OGG1, in action-at-a-distance mutation induction by 8-oxo-7,8-dihydroguanine.

H. Kamiya, Tetsuya Suzuki, Y. Zaima, 2022, DNA repair.

Action-at-a-distance mutations at 5'-GpA-3' sites induced by oxidized guanine in WRN-knockdown cells.

H. Kamiya, H. Masuda, Tetsuya Suzuki, 2021, Mutagenesis.

Efficient and erroneous incorporation of oxidized DNA precursors by human DNA polymerase eta.

Yan Xu, H. Sugiyama, F. Hanaoka, 2007, Biochemistry.

Mutagenesis induced by oxidized DNA precursors: roles of Y family DNA polymerases in Escherichia coli.

M. Yamada, H. Harashima, H. Kamiya, 2005, Chemical research in toxicology.

Increased A:T-->C:G mutations in the mutT strain upon 8-hydroxy-dGTP treatment: direct evidence for MutT involvement in the prevention of mutations by oxidized dGTP.

H. Harashima, H. Kamiya, Chieko Ishiguro, 2004, Journal of biochemistry.

Increased A:T to C:G mutations in the mutT strain upon 8-hydroxy-dGTP treatment: Direct evidence for MutT in the prevention of mutations by oxidized dGTP

H. Harashima, H. Kamiya, Chieko Ishiguro, 2004 .

Glyoxal, a major product of DNA oxidation, induces mutations at G:C sites on a shuttle vector plasmid replicated in mammalian cells.

H. Kamiya, N. Murata‐Kamiya, H. Kasai, 1997, Nucleic acids research.

Transient activation of transgene expression by hydrodynamics-based injection may cause rapid decrease in plasmid DNA expression

M. Fujimuro, H. Yokosawa, H. Ochiai, 2007, Gene Therapy.

Intranuclear disposition of exogenous DNA in vivo: Silencing, methylation and fragmentation

Hiroshi Ochiai, Hideyoshi Harashima, Hiroyuki Kamiya, 2006, FEBS letters.

The (6-4) photoproduct of thymine-thymine induces targeted substitution mutations in mammalian cells.

S. Iwai, H. Kamiya, H. Kasai, 1998, Nucleic acids research.

Design of RNA enzymes distinguishing a single base mutation in RNA.

E. Ohtsuka, S. Iwai, H. Kamiya, 1989, Nucleic acids research.

DNA microarray analysis of whole blood cells and insulin-sensitive tissues reveals the usefulness of blood RNA profiling as a source of markers for predicting type 2 diabetes.

N. Kaji, Y. Baba, H. Harashima, 2010, Biological & pharmaceutical bulletin.

2-Hydroxy-dATP is incorporated opposite G by Escherichia coli DNA polymerase III resulting in high mutagenicity.

H. Kamiya, H. Kasai, 2000, Nucleic acids research.

Enhanced transgene expression by plasmid-specific recruitment of histone acetyltransferase.

H. Harashima, H. Kamiya, Tetsuya Suzuki, 2017, Journal of bioscience and bioengineering.

2-Hydroxyadenine, a mutagenic form of oxidative DNA damage, is not repaired by a glycosylase type mechanism in rat organs.

H. Itoh, T. Hirano, H. Kamiya, 1998, Mutation research.

2-Hydroxy-2'-deoxyadenosine 5'-triphosphate enhances A.T --> C.G mutations caused by 8-hydroxy-2'-deoxyguanosine 5'-triphosphate by suppressing its degradation upon replication in a HeLa extract.

F. Hanaoka, H. Harashima, H. Kamiya, 2007, Biochemistry.

Instructions for use Title Effects of insulator cHS 4 on transgene expression from plasmid DNA in a positive feedback system

H. Ochiai, H. Harashima, H. Kamiya, 2018 .

Effects of insulator cHS4 on transgene expression from plasmid DNA in a positive feedback system.

H. Ochiai, H. Harashima, H. Kamiya, 2011, Journal of bioscience and bioengineering.

Action-at-a-distance mutagenesis induced by oxidized guanine in Werner syndrome protein-reduced human cells.

H. Harashima, H. Kamiya, I. Matsuoka, 2015, Chemical Research in Toxicology.

Targeted sequence alteration of a chromosomal locus in mouse liver.

J. Piao, Y. Nakatsu, T. Tsuzuki, 2010, International journal of pharmaceutics.

Improved gene correction efficiency with a tailed duplex DNA fragment.

Y. Nakatsu, T. Tsuzuki, H. Harashima, 2008, Biochemistry.

Single-stranded DNA versus tailed duplex in sequence conversion of lacZα DNA

H. Kawai, H. Kamiya, Tetsuya Suzuki, 2020, Nucleosides, nucleotides & nucleic acids.

Effects of mismatches distant from the target position on gene correction with a 5'-tailed duplex.

Y. Nakatsu, T. Tsuzuki, H. Kamiya, 2018, Journal of bioscience and bioengineering.

Comparison of DNA fragments as donor DNAs upon sequence conversion of cleaved target DNA

Y. Komatsu, H. Kamiya, Tetsuya Suzuki, 2017, Nucleosides, nucleotides & nucleic acids.

Cleavage of Target DNA Promotes Sequence Conversion with a Tailed Duplex.

H. Kamiya, I. Matsuoka, Tetsuya Suzuki, 2016, Biological & pharmaceutical bulletin.

Insertion and Deletion Mismatches Distant from the Target Position Improve Gene Correction with a Tailed Duplex

Y. Nakatsu, T. Tsuzuki, H. Harashima, 2016, Nucleosides, nucleotides & nucleic acids.

Correction of frameshift mutations with tailed duplex DNAs.

H. Harashima, H. Kamiya, H. Tsuchiya, 2011, Biological & pharmaceutical bulletin.

Cyclobutane thymine dimers in a ras proto-oncogene hot spot activate the gene by point mutation.

F. Hanaoka, A. Matsukage, E. Ohtsuka, 1993, Nucleic acids research.

Enhanced transgene expression from chromatinized plasmid DNA in mouse liver.

H. Harashima, H. Kamiya, I. Matsuoka, 2013, International journal of pharmaceutics.

Transgene expression efficiency from plasmid DNA delivered as a complex with histone H3.

H. Harashima, Yuma Yamada, H. Kamiya, 2010, International journal of pharmaceutics.

Mechanism of improved gene transfer by the N-terminal stearylation of octaarginine: enhanced cellular association by hydrophobic core formation

H Harashima, S. Futaki, H. Harashima, 2004, Gene Therapy.

Development of oligonucleotide lateral-flow immunoassay for multi-parameter detection.

H. Kamiya, H Kamiya, Y Oku, 2001, Journal of immunological methods.

Genome wide expression analysis of white blood cells and liver of pre-diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats using a cDNA microarray.

N. Kaji, Y. Baba, Y. Shinohara, 2006, Biological & pharmaceutical bulletin.

DNA microarray analysis of type 2 diabetes-related genes co-regulated between white blood cells and livers of diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats.

N. Kaji, Y. Baba, H. Harashima, 2007, Biological & pharmaceutical bulletin.

Dual hydrolysis of diphosphate and triphosphate derivatives of oxidized deoxyadenosine by Orf17 (NtpA), a MutT-type enzyme.

H. Harashima, H. Kamiya, H. Kasai, 2005, DNA repair.

Troglitazone suppresses cell growth of KU812 cells independently of PPARgamma.

Y. Tokumitsu, H. Harashima, H. Kamiya, 2002, European journal of pharmacology.

The location of the left-handedly curved DNA sequence affects exogenous DNA expression in vivo.

Hideyoshi Harashima, Hiroyuki Kamiya, H. Harashima, 2007, Archives of biochemistry and biophysics.

Size and topology of exogenous DNA as determinant factors of transgene transcription in mammalian cells

H. Harashima, H. Kamiya, J. Yamazaki, 2006, Gene Therapy.

Induction of action-at-a-distance mutagenesis by 8-oxo-7,8-dihydroguanine in DNA pol λ-knockdown cells

H. Kamiya, I. Matsuoka, Miwako Kobayashi, 2015, Genes and Environment.

Important amino acids in the phosphohydrolase module of Escherichia coli Orf135.

H. Harashima, H. Kamiya, E. Iida, 2004, Biochemical and biophysical research communications.

Two DNA polymerases of Escherichia coli display distinct misinsertion specificities for 2-hydroxy-dATP during DNA synthesis.

H. Maki, H. Kamiya, H. Kasai, 2000, Biochemistry.

Positive feedback system provides efficient and persistent transgene expression.

H. Ochiai, H. Harashima, H. Kamiya, 2010, Molecular pharmaceutics.

Analysis of large deletion mutations induced by abasic site analog in human cells

Y. Komatsu, H. Kamiya, Tetsuya Suzuki, 2018, Genes and Environment.

Amino acid residues involved in substrate recognition of the Escherichia coli Orf135 protein.

C. Kojima, H. Harashima, H. Kamiya, 2005, Biochemistry.

1H, 13C and 15N NMR assignments of the Escherichia coli Orf135 protein

C. Kojima, H. Harashima, H. Kamiya, 2012, Biomolecular NMR assignments.

Mutagenicity of 5-formylcytosine, an oxidation product of 5-methylcytosine, in DNA in mammalian cells.

A. Matsuda, H. Harashima, H. Kamiya, 2002, Journal of biochemistry.

High-throughput analysis of DNA repair in microplates towards identification of inhibitors

H. Kamiya, 2020, Genes and Environment.

Factors affecting SFHR gene correction efficiency with single-stranded DNA fragment.

Hideyoshi Harashima, Hiroyuki Kamiya, Hiroyuki Tsuchiya, 2005, Biochemical and biophysical research communications.

Correction of frameshift mutations with single-stranded and double-stranded DNA fragments prepared from phagemid/plasmid DNAs.

Hideyoshi Harashima, Hiroyuki Kamiya, Hiroyuki Tsuchiya, 2005, Biological & pharmaceutical bulletin.