D. Spengler

T. Goldmann, D. Schwudke, A. Schromm, 2022, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Validation of a predictive model for identifying an increased risk for recurrence in adolescents and young adults with a first provoked thromboembolism

R. Junker, D. Spengler, M. Stoll, 2022, Blood Cells, Molecules, and Diseases.

Induction of the PAC1-R (PACAP-type I receptor) gene by p53 and Zac.

E. Ciani, L. Journot, D. Spengler, 1999, Brain research. Molecular brain research.

Zac1 Regulates Cell Cycle Arrest in Neuronal Progenitors via Tcf4

D. Spengler, A. Hoffmann, G. Daniel, 2014, Molecular and Cellular Biology.

Differential regulation and function of 5'-untranslated GR-exon 1 transcripts.

I. Adcock, D. Spengler, O. Almeida, 2011, Molecular endocrinology.

An Unsettled Promise: The Newborn Piglet Model of Neonatal Acute Respiratory Distress Syndrome (NARDS). Physiologic Data and Systematic Review

D. Spengler, M. Krause, Nele Rintz, 2019, Front. Physiol..

Glucocorticoid repression of 3',5'-cyclic-adenosine monophosphate-dependent human corticotropin-releasing-hormone gene promoter activity in a transfected mouse anterior pituitary cell line.

F. Holsboer, D. Spengler, L. P. Van, 1990, Endocrinology.

The PACAP receptor: generation by alternative splicing of functional diversity among G protein-coupled receptors in nerve cells.

J. Bockaert, L. Journot, D. Spengler, 1994, Seminars in cell biology.

Dynamic DNA methylation programs persistent adverse effects of early-life stress

F. Holsboer, C. Wotjak, Yonghe Wu, 2009, Nature Neuroscience.

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain

D. Spengler, O. Almeida, Marc Bettscheider, 2012, Journal of visualized experiments : JoVE.

Diabetes insipidus and, partially, low anxiety‐related behaviour are linked to a SNP‐associated vasopressin deficit in LAB mice

F. Holsboer, W. Jacob, E. Frank, 2007, The European journal of neuroscience.

Differential signal transduction by six splice variants of the pituitary adenylate cyclase-activating peptide (PACAP) receptor.

F. Holsboer, J. Bockaert, P. Seeburg, 1995, Biochemical Society transactions.

Regulation of apoptosis and cell cycle arrest by Zac 1 , a novel zinc finger protein expressed in the pituitary gland and the brain regulate progression of the cell cycle by sequential form -

J. Bockaert, L. Journot, D. Spengler, 2013 .

Genetic Variation in the Epigenetic Machinery and Mental Health

D. Spengler, C. Murgatroyd, 2012, Current Psychiatry Reports.

Molecular epigenetic switches in neurodevelopment in health and disease

D. Spengler, A. Hoffmann, Christoph A. Zimmermann, 2015, Front. Behav. Neurosci..

Genes learn from stress: How infantile trauma programs us for depression

Yonghe Wu, D. Spengler, C. Murgatroyd, 2010, Epigenetics.

Epigenomics of Major Depressive Disorders and Schizophrenia: Early Life Decides

D. Spengler, A. Hoffmann, M. Ziller, 2017, International journal of molecular sciences.

Differences in Histone Modifications Between Individuals

E. Binder, D. Spengler, A. Hoffmann, 2015 .

Neurocutaneous Melanosis: A Fatal Disease in Early Childhood

A. Hauschild, E. Livingstone, D. Spengler, 2009 .

Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain

J. Bockaert, L. Journot, D. Spengler, 1997, The EMBO journal.

Early-life stress reduces DNA methylation of the Pomc gene in male mice.

Yonghe Wu, D. Spengler, O. Almeida, 2014, Endocrinology.

The Mitochondrion as Potential Interface in Early-Life Stress Brain Programming

D. Spengler, A. Hoffmann, 2018, Front. Behav. Neurosci..

Tracing Early Neurodevelopment in Schizophrenia with Induced Pluripotent Stem Cells

D. Spengler, A. Hoffmann, M. Ziller, 2018, Cells.

Single-Cell Transcriptomics Supports a Role of CHD8 in Autism

D. Spengler, A. Hoffmann, 2021, International journal of molecular sciences.

Chromatin Remodeler CHD8 in Autism and Brain Development

D. Spengler, A. Hoffmann, 2021, Journal of clinical medicine.

Epigenetics and Neuroendocrinology

E. Binder, D. Spengler, 2016, Epigenetics and Human Health.

Site‐specific and endothelial‐mediated dysfunction of the alveolar‐capillary barrier in response to lipopolysaccharides

A. Tholey, S. Fuchs, D. Spengler, 2017, Journal of cellular and molecular medicine.

Focus on Causality in ESC/iPSC-Based Modeling of Psychiatric Disorders

D. Spengler, A. Hoffmann, M. Ziller, 2020, Cells.

DNA memories of early social life

D. Spengler, A. Hoffmann, 2014, Neuroscience.

The lasting legacy of social stress on the epigenome of the hypothalamic-pituitary-adrenal axis.

D. Spengler, A. Hoffmann, 2012, Epigenomics.

Role of Mecp2 in Experience-Dependent Epigenetic Programming

D. Spengler, A. Hoffmann, Christoph A. Zimmermann, 2015, Genes.

Epigenetic Risk Factors in PTSD and Depression

D. Spengler, F. Raabe, 2013, Front. Psychiatry.

Progress in iPSC-Based Modeling of Psychiatric Disorders

D. Spengler, A. Hoffmann, M. Ziller, 2019, International journal of molecular sciences.

A Hypomorphic Vasopressin Allele Prevents Anxiety-Related Behavior

Nicolas Singewald, Florian Holsboer, Benno Pütz, 2009, PloS one.

Loss of expression of the candidate tumor suppressor gene ZAC in breast cancer cell lines and primary tumors

J. Bockaert, C. Theillet, A. Mazumdar, 1999, Oncogene.

hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer.

F. Apiou, J. Bockaert, E. Ciani, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Driver or Passenger: Epigenomes in Alzheimer’s Disease

D. Spengler, A. Hoffmann, M. Ziller, 2017 .

Epigenetics of Early Child Development

D. Spengler, C. Murgatroyd, 2011, Front. Psychiatry.

Roles of imprinted genes in neural stem cells.

D. Spengler, A. Hoffmann, G. Daniel, 2014, Epigenomics.

Switch-Like Roles for Polycomb Proteins from Neurodevelopment to Neurodegeneration

D. Spengler, A. Hoffmann, M. Ziller, 2017 .

Methylation at the CpG island shore region upregulates Nr3c1 promoter activity after early-life stress

F. Holsboer, N. Sousa, D. Spengler, 2015, Epigenetics.

Untitled

F. Holsboer, D. Spengler, O. Almeida, 2015 .

Multitasking C2H2 Zinc Fingers Link Zac DNA Binding to Coordinated Regulation of p300-Histone Acetyltransferase Activity

T. Barz, D. Spengler, A. Hoffmann, 2006, Molecular and Cellular Biology.

Beta(2)-adrenergic receptors potentiate glucocorticoid receptor transactivation via G protein beta gamma-subunits and the phosphoinositide 3-kinase pathway.

F. Holsboer, D. Spengler, P. Schmidt, 2001, Molecular endocrinology.

The role of corticotropin-releasing hormone in the pathogenesis of Cushing's disease, anorexia nervosa, alcoholism, affective disorders and dementia.

I. Heuser, F. Holsboer, D. Spengler, 1992, Progress in brain research.

The future is now: early life events preset adult behaviour

D. Spengler, A. Patchev, N. Sousa, 2014, Acta physiologica.

Alternative Splicing in the N-terminal Extracellular Domain of the Pituitary Adenylate Cyclase-activating Polypeptide (PACAP) Receptor Modulates Receptor Selectivity and Relative Potencies of PACAP-27 and PACAP-38 in Phospholipase C Activation*

J. Bockaert, L. Journot, P. Brabet, 1996, The Journal of Biological Chemistry.

A novel tetracycline-dependent expression vector with low basal expression and potent regulatory properties in various mammalian cell lines.

L. Journot, D. Spengler, A. Hoffmann, 1997, Nucleic acids research.

β2-adrenergic receptors potentiate glucocorticoid receptor transactivation via G protein βγ-subunits and the phosphoinositide 3-kinase pathway.

F. Holsboer, D. Spengler, P. Schmidt, 2001 .

b 2-Adrenergic Receptors Potentiate Glucocorticoid Receptor Transactivation via G Protein bg-Subunits and the Phosphoinositide 3-Kinase Pathway

F. Holsboer, D. Spengler, P. Schmidt, 2001 .

Transactivation and synergistic properties of the mineralocorticoid receptor: relationship to the glucocorticoid receptor.

F. Holsboer, R. Evans, R. Rupprecht, 1993, Molecular endocrinology.

Role of ZAC1 in transient neonatal diabetes mellitus and glucose metabolism.

D. Spengler, A. Hoffmann, 2015, World journal of biological chemistry.

Imprinted Zac1 in neural stem cells.

D. Spengler, A. Hoffmann, G. Daniel, 2015, World journal of stem cells.

Sex differences in brain epigenetics.

D. Spengler, C. Murgatroyd, Marc Bettscheider, 2010, Epigenomics.

Novel therapeutic roles for surfactant-inositols and -phosphatidylglycerols in a neonatal piglet ARDS model: a translational study.

C. Vock, A. Schromm, S. Fuchs, 2018, American journal of physiology. Lung cellular and molecular physiology.

iPSC-based modeling in psychiatric disorders

D. Spengler, A. Hoffmann, M. Ziller, 2022, Novel Concepts in iPSC Disease Modeling.

From the Psychiatrist’s Couch to Induced Pluripotent Stem Cells: Bipolar Disease in a Dish

D. Spengler, A. Hoffmann, M. Ziller, 2018, International journal of molecular sciences.

Polycomb Binding Precedes Early-Life Stress Responsive DNA Methylation at the Avp Enhancer

D. Spengler, C. Murgatroyd, 2014, PloS one.

Simultaneous DNA and RNA isolation from brain punches for epigenetics

D. Spengler, C. Murgatroyd, Marc Bettscheider, 2011, BMC Research Notes.

Environmental factors and epigenetics of neuropsychiatric disorders

D. Spengler, A. Hoffmann, 2017 .

Zac1 Regulates Astroglial Differentiation of Neural Stem Cells Through Socs3

D. Spengler, A. Hoffmann, G. Daniel, 2013, Stem cells.

Transient Neonatal Diabetes Mellitus Gene Zac1 Impairs Insulin Secretion in Mice through Rasgrf1

D. Spengler, A. Hoffmann, 2012, Molecular and Cellular Biology.

ZAC1 target genes and pituitary tumorigenesis

G. Stalla, M. Theodoropoulou, D. Spengler, 2010, Molecular and Cellular Endocrinology.

A New Coactivator Function for Zac1's C2H2 Zinc Finger DNA-Binding Domain in Selectively Controlling PCAF Activity

D. Spengler, A. Hoffmann, 2008, Molecular and Cellular Biology.

Alternative splicing of the imprinted candidate tumor suppressor gene ZAC regulates its antiproliferative and DNA binding activities

J. Bockaert, A. Mazumdar, L. Journot, 2001, Oncogene.

The expression of the antiproliferative gene ZAC is lost or highly reduced in nonfunctioning pituitary adenomas.

T. Arzberger, W. Saeger, M. Losa, 2000, Cancer research.

How infantile trauma programs us for depression

Yonghe Wu, D. Spengler, C. Murgatroyd, 2010 .

In vivo ChIP for the analysis of microdissected tissue samples.

D. Spengler, C. Murgatroyd, A. Hoffmann, 2012, Methods in molecular biology.

Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands.

F. Holsboer, B. van Steensel, R. Rupprecht, 1993, European journal of pharmacology.

Evidence from increased anticipation of predictive saccades for a dysfunction of fronto-striatal circuits in obsessive–compulsive disorder

W. Heide, R. Lencer, P. Trillenberg, 2006, Psychiatry Research.

An adverse early life environment can enhance stress resilience in adulthood

E. Binder, D. Spengler, J. Arloth, 2017, Psychoneuroendocrinology.

Histone tales: echoes from the past, prospects for the future

D. Spengler, C. Murgatroyd, 2010, Genome Biology.

The Janus face of DNA methylation in aging

Yonghe Wu, D. Spengler, Yvonne Bockmühl, 2010, Aging.

Functional properties of deoxycorticosterone and spironolactone: molecular characterization and effects on sleep-endocrine activity.

A. Steiger, F. Holsboer, J. Guldner, 1993, Journal of psychiatric research.

Impaired Repression at a Vasopressin Promoter Polymorphism Underlies Overexpression of Vasopressin in a Rat Model of Trait Anxiety

F. Holsboer, E. Frank, D. Spengler, 2004, The Journal of Neuroscience.

Supine vs. Prone Position With Turn of the Head Does Not Affect Cerebral Perfusion and Oxygenation in Stable Preterm Infants ≤32 Weeks Gestational Age

D. Spengler, M. Krause, Elisa Loewe, 2018, Front. Physiol..

Epigenetic programming of the HPA axis: Early life decides

D. Spengler, C. Murgatroyd, 2011, Stress.

Induction of Type I PACAP Receptor Expression by the New Zinc Finger Protein Zac1 and p53

E. Ciani, L. Journot, P. Brabet, 1998, Annals of the New York Academy of Sciences.

Inhibition of Zac1, a new gene differentially expressed in the anterior pituitary, increases cell proliferation.

T. Arzberger, U. Pagotto, E. Ciani, 1999, Endocrinology.

A New Coactivator Function for Zac1's C2H2 Zinc Finger DNA-Binding Domain in Selectively Controlling PCAF Activity

D. Spengler, A. Hoffmann, 2008, Molecular and Cellular Biology.

Isolation of high-quality DNA for genotyping from feces of rodents.

D. Spengler, D. Bilko, C. Murgatroyd, 2006, Analytical biochemistry.

Transient Neonatal Diabetes Mellitus Gene Zac1 Impairs Insulin Secretion in Mice through Rasgrf1

D. Spengler, A. Hoffmann, 2012, Molecular and Cellular Biology.

Epigenetics and Human Health

E. Binder, D. Spengler, 2016 .