G. Jayandharan

发表

Intracellular Trafficking of AAV5 Vectors.

Balaji Balakrishnan, G. Jayandharan, 2016, Human gene therapy methods.

Optimized adeno-associated virus (AAV)-protein phosphatase-5 helper viruses for efficient liver transduction by single-stranded AAV vectors: therapeutic expression of factor IX at reduced vector doses.

B. Sack, G. Jayandharan, L. Zhong, 2010, Human gene therapy.

Hemophilia: Genetics, Diagnosis and Treatment

G. Jayandharan, A. Srivastava, A. Srivastava, 2011 .

Bioengineering of AAV2 capsid at specific serine, threonine, or lysine residues improves its transduction efficiency in vitro and in vivo.

N. Srinivasan, G. Sudha, R. Gadkari, 2013, Human gene therapy methods.

High-efficiency transduction of human monocyte-derived dendritic cells by capsid-modified recombinant AAV2 vectors.

L. Govindasamy, M. Agbandje-McKenna, S. Zolotukhin, 2012, Vaccine.

Genetics of haemostasis

D. Perry, G. Jayandharan, E. Tuddenham, 2012, Haemophilia : the official journal of the World Federation of Hemophilia.

Basic biology of adeno-associated virus (AAV) vectors used in gene therapy.

Balaji Balakrishnan, G. Jayandharan, 2014, Current gene therapy.

Activation of the NF-κB pathway by adeno-associated virus (AAV) vectors and its implications in immune response and gene therapy

G. Jayandharan, R. Herzog, A. Srivastava, 2011, Proceedings of the National Academy of Sciences.

Developing immunologically inert adeno-associated virus (AAV) vectors for gene therapy: possibilities and limitations.

G. Jayandharan, Sangeetha Hareendran, Ruchita Selot, 2014, Current pharmaceutical biotechnology.

Molecular screening of the neutrophil elastase gene in congenital neutropenia.

M. Chandy, G. Jayandharan, M. Thomas, 2006, Indian pediatrics.

Diffuse Large B Cell Lymphoma in Wiskott-Aldrich Syndrome: A Case Report and Review of Literature

B. George, G. Jayandharan, S. David, 2014, Indian Journal of Hematology and Blood Transfusion.

Rational Engineering and Preclinical Evaluation of Neddylation and SUMOylation Site Modified Adeno-Associated Virus Vectors in Murine Models of Hemophilia B and Leber Congenital Amaurosis

G. Jayandharan, Shubham Maurya, B. Mary, 2019, Human gene therapy.

The phenotypic heterogeneity of severe hemophilia.

A. Srivastava, G. Jayandharan, A. Srivastava, 2008, Seminars in thrombosis and hemostasis.

Nuclear factor (NF)‐κB and its associated pathways are major molecular regulators of blood‐induced joint damage in a murine model of hemophilia

D. Sen, G. Jayandharan, A. Srivastava, 2013, Journal of thrombosis and haemostasis : JTH.

Molecular Engineering of Adeno-Associated Virus Capsid Improves Its Therapeutic Gene Transfer in Murine Models of Hemophilia and Retinal Degeneration

M. Kumar, G. Jayandharan, Vikas Kumar, 2019, Molecular pharmaceutics.

Synergistic inhibition of PARP‐1 and NF‐κB signaling downregulates immune response against recombinant AAV2 vectors during hepatic gene therapy

G. Jayandharan, Sangeetha Hareendran, B. Ramakrishna, 2016, European journal of immunology.

Targeted delivery of AAV‐transduced mesenchymal stromal cells to hepatic tissue for ex vivo gene therapy

G. Jayandharan, N. Gabriel, Rekha Samuel, 2017, Journal of tissue engineering and regenerative medicine.

Molecular basis of quantitative fibrinogen disorders in 27 patients from India

B. George, A. Viswabandya, M. Chandy, 2013, Haemophilia : the official journal of the World Federation of Hemophilia.

Molecular basis of Bernard–Soulier syndrome in 27 patients from India

B. George, A. Viswabandya, M. Chandy, 2011, Journal of thrombosis and haemostasis : JTH.

Quality issues in laboratory haemostasis

G. Lippi, G. Jayandharan, A. Srivastava, 2010, Haemophilia : the official journal of the World Federation of Hemophilia.

Calpeptin Increases the Activity of Upstream Stimulatory Factor and Induces High Level Globin Gene Expression in Erythroid Cells*

Arun Srivastava, G. Jayandharan, L. Zhong, 2009, The Journal of Biological Chemistry.

Development of Novel Recombinant AAV Vectors and Strategies for the Potential Gene Therapy of Hemophilia.

S. Zolotukhin, G. Jayandharan, L. Zhong, 2012, Journal of genetic syndromes & gene therapy.

A simple method to increase the transduction efficiency of single-stranded adeno-associated virus vectors in vitro and in vivo.

B. Byrne, G. Jayandharan, Baozheng Li, 2011, Human gene therapy.

Optimizing the transduction efficiency of capsid-modified AAV6 serotype vectors in primary human hematopoietic stem cells in vitro and in a xenograft mouse model in vivo.

Liujiang Song, G. Jayandharan, L. Zhong, 2013, Cytotherapy.

Optimizing the transduction efficiency of human hematopoietic stem cells using capsid-modified AAV6 vectors in vitro and in a xenograft mouse model in vivo

Arun Srivastava, Liujiang Song, G. Jayandharan, 2013 .

Role of Molecular Genetics in Hemophilia: From Diagnosis to Therapy

Arun Srivastava, G. Jayandharan, A. Srivastava, 2012, Seminars in Thrombosis & Hemostasis.

Activation of the Cellular Unfolded Protein Response by Recombinant Adeno-Associated Virus Vectors

D. Sen, Balaji Balakrishnan, G. Jayandharan, 2013, PloS one.

Post‐translational modifications in capsid proteins of recombinant adeno‐associated virus (AAV) 1‐rh10 serotypes

G. Jayandharan, Vikas Kumar, Shubham Maurya, 2019, The FEBS journal.

Molecular basis of Wiskott–Aldrich syndrome in patients from India

B. George, A. Viswabandya, M. Chandy, 2012, European journal of haematology.

Enhanced Transgene Expression from Recombinant Single-Stranded D-Sequence-Substituted Adeno-Associated Virus Vectors in Human Cell Lines In Vitro and in Murine Hepatocytes In Vivo

R. Samulski, N. Muzyczka, Xiao Xiao, 2014, Journal of Virology.

recombinant AAV vectors in human cell lines in vitro and in murine hepatocytes in

R. Samulski, N. Muzyczka, Xiao Xiao, 2014 .

Adeno-associated virus serotype 6 capsid tyrosine-to-phenylalanine mutations improve gene transfer to skeletal muscle.

D. Duan, Xiao Xiao, G. Jayandharan, 2010, Human gene therapy.

Genetic diagnosis of haemophilia and other inherited bleeding disorders

P. Mannucci, M. Chandy, S. Duga, 2006, Haemophilia : the official journal of the World Federation of Hemophilia.

Polymorphism in factor VII gene modifies phenotype of severe haemophilia

B. George, K. Lakshmi, A. Viswabandya, 2009, Haemophilia : the official journal of the World Federation of Hemophilia.

MicroRNA-15b Modulates Molecular Mediators of Blood Induced Arthropathy in Hemophilia Mice

D. Sen, G. Jayandharan, 2016, International journal of molecular sciences.

Informativeness of linkage analysis for genetic diagnosis of haemophilia A in India

B. George, M. Chandy, G. Jayandharan, 2004, Haemophilia : the official journal of the World Federation of Hemophilia.

Identification of factor VIII gene mutations in 101 patients with haemophilia A: mutation analysis by inversion screening and multiplex PCR and CSGE and molecular modelling of 10 novel missense substitutions

M. Chandy, G. Jayandharan, A. Srivastava, 2005, Haemophilia : the official journal of the World Federation of Hemophilia.

Six novel mutations including triple heterozygosity for Phe31Ser, 514delT and 516T→G factor X gene mutations are responsible for congenital factor X deficiency in patients of Nepali and Indian origin

B. George, A. Viswabandya, M. Chandy, 2005, Journal of thrombosis and haemostasis : JTH.

Fluorescent PCR‐based gene dose analysis for detection of deletion mutations in carriers of haemophilia

S. Rajkumar, G. Jayandharan, S. Rajkumar, 2013, Haemophilia : the official journal of the World Federation of Hemophilia.

Argatroban inhibits staphylothrombin

F. Rosendaal, M. Chandy, G. Jayandharan, 2003, Journal of thrombosis and haemostasis : JTH.

Cellular unfolded protein response against viruses used in gene therapy

D. Sen, Balaji Balakrishnan, G. Jayandharan, 2014, Front. Microbiol..

High-efficiency transduction and correction of murine hemophilia B using AAV2 vectors devoid of multiple surface-exposed tyrosines.

S. Zolotukhin, G. Jayandharan, L. Zhong, 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

Improved adeno-associated virus (AAV) serotype 1 and 5 vectors for gene therapy

D. Sen, Balaji Balakrishnan, G. Jayandharan, 2013, Scientific Reports.

246. Intra-Articular Gene Transfer of miR-15b Attenuates Molecular Mediators of Hemophilic Arthropathy in a Murine Model of Hemophilia

D. Sen, G. Jayandharan, P. Vemula, 2015 .

Mutations in the MCFD2 gene are predominant among patients with hereditary combined FV and FVIII deficiency (F5F8D) in India

A. Viswabandya, M. Chandy, G. Jayandharan, 2007, Haemophilia : the official journal of the World Federation of Hemophilia.

Gene and Cell Therapy: Biology and Applications

G. Jayandharan, 2018, Springer Singapore.

Combination Suicide Gene Delivery with an Adeno-Associated Virus Vector Encoding Inducible Caspase-9 and a Chemical Inducer of Dimerization Is Effective in a Xenotransplantation Model of Hepatocellular Carcinoma.

G. Jayandharan, S. Chattopadhyay, N. Khan, 2019, Bioconjugate chemistry.

Analysis of hepatic and retinal cell microRNAome during AAV infection reveals their diverse impact on viral transduction and cellular physiology.

M. Kumar, G. Jayandharan, B. Mary, 2020, Gene.

Ezh2 mediated H3K27me3 activity facilitates somatic transition during human pluripotent reprogramming

G. Jayandharan, Dasaradhi Palakodeti, S. Cheemadan, 2015, Scientific Reports.

Vector engineering, strategies and targets in cancer gene therapy

G. Jayandharan, Vijayata Singh, N. Khan, 2021, Cancer Gene Therapy.

High-efficiency transduction of fibroblasts and mesenchymal stem cells by tyrosine-mutant AAV2 vectors for their potential use in cellular therapy.

G. Jayandharan, L. Zhong, Mengxin Li, 2010, Human gene therapy.

Improved ocular gene transfer with a Neddylation-site modified AAV-RPE65 vector in rd12 mice

G. Jayandharan, Shubham Maurya, B. Mary, 2020, Eye.

Molecular basis of hereditary factor V deficiency in India: Identification of four novel mutations and their genotype-phenotype correlation

B. George, A. Viswabandya, V. Mathews, 2011, Thrombosis and Haemostasis.

Strategies for improving the transduction efficiency of single-stranded adeno-associated virus vectors in vitro and in vivo

G. Jayandharan, L. Zhong, Baozheng Li, 2008, Gene Therapy.

AAV6 Vexosomes Mediate Robust Suicide Gene Delivery in a Murine Model of Hepatocellular Carcinoma

G. Jayandharan, N. Khan, Shubham Maurya, 2020, Molecular therapy. Methods & clinical development.

MicroRNA‐based recombinant AAV vector assembly improves efficiency of suicide gene transfer in a murine model of lymphoma

G. Jayandharan, S. Cheemadan, N. Khan, 2020, Cancer medicine.

Molecular characterization of novel Adeno-associated virus variants infecting human tissues.

Apurv Jain, V. Mathews, G. Jayandharan, 2019, Virus research.

Viral- and Non-viral-Based Hybrid Vectors for Gene Therapy

M. Mahato, G. Jayandharan, P. Vemula, 2018 .

Optimized AAV rh.10 Vectors That Partially Evade Neutralizing Antibodies during Hepatic Gene Transfer

G. Jayandharan, Ruchita Selot, S. Cheemadan, 2017, Front. Pharmacol..

Adeno‐associated virus (AAV) vectors in gene therapy: immune challenges and strategies to circumvent them

D. Sen, Balaji Balakrishnan, G. Jayandharan, 2013, Reviews in medical virology.

High-Efficiency Transduction of Primary Human Hematopoietic Stem Cells and Erythroid Lineage-Restricted Expression by Optimized AAV6 Serotype Vectors In Vitro and in a Murine Xenograft Model In Vivo

G. Gao, Liujiang Song, G. Jayandharan, 2013, PloS one.

Targeted modifications in adeno-associated virus serotype 8 capsid improves its hepatic gene transfer efficiency in vivo.

N. Srinivasan, G. Sudha, R. Gadkari, 2012, Human gene therapy methods.

irus (AAV) vectors in gene allenges and strategies to circumvent them

D. Sen, Balaji Balakrishnan, G. Jayandharan, 2013 .

Gene Therapy: Contest between Adeno-Associated Virus and Host Cells and the Impact of UFMylation.

G. Jayandharan, Shubham Maurya, 2020, Molecular pharmaceutics.

Adeno-associated Virus Vectors in Gene Therapy

G. Jayandharan, Mohit Kumar, S. Chattopadhyay, 2018 .

Innate Immune Responses to AAV Vectors

G. Rogers, G. Jayandharan, R. Herzog, 2011, Front. Microbio..

An efficient method to generate xenograft tumor models of acute myeloid leukemia and hepatocellular carcinoma in adult zebrafish.

G. Jayandharan, N. Khan, P. Sinha, 2019, Blood cells, molecules & diseases.

Efficient lysis of epithelial ovarian cancer cells by MAGE-A3-induced cytotoxic T lymphocytes using rAAV-6 capsid mutant vector.

B. Kolli, R. Batchu, Oksana V. Gruzdyn, 2014, Vaccine.

Infectivity of adeno-associated virus serotypes in mouse testis

Jayaprakash Periasamy, D. Sen, R. Sambasivan, 2018, BMC Biotechnology.

A CD33 antigen targeted AAV6 vector expressing an inducible caspase-9 suicide gene is therapeutic in a xenotransplantation model of acute myeloid leukemia.

G. Jayandharan, N. Khan, S. Bammidi, 2019, Bioconjugate chemistry.

Novel missense mutations in two patients with factor XI deficiency (Val271Leu and Tyr351Ser) and one patient with combined factor XI and factor IX deficiency (Phe349Val)

M. Chandy, G. Jayandharan, A. Srivastava, 2005, Journal of thrombosis and haemostasis : JTH.

Exosome-associated SUMOylation mutant AAV demonstrates improved ocular gene transfer efficiency in vivo

G. Jayandharan, Shubham Maurya, 2020, Virus research.

A new multiplex PCR and conformation‐sensitive gel electrophoresis strategy for mutation detection in the platelet glycoprotein αIIb and β3 genes

M. Chandy, G. Jayandharan, A. Srivastava, 2007, Journal of thrombosis and haemostasis : JTH.

Molecular genetics of hereditary prothrombin deficiency in Indian patients: identification of a novel Ala362→Thr (Prothrombin Vellore 1) mutation

A. Viswabandya, M. Chandy, G. Jayandharan, 2005, Journal of thrombosis and haemostasis : JTH.

Molecular basis of hereditary factor VII deficiency in India: five novel mutations including a double missense mutation (Ala191Glu; Trp364Cys) in 11 unrelated patients.

A. Viswabandya, M. Chandy, G. Jayandharan, 2007, Haematologica.

A novel mutation c.1048A>T at codon 350(Lys>Stop) in PROC gene causing neonatal purpura fulminans

G. Jayandharan, Jolly Chandran, P. Moses, 2013, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina.

W. Hauswirth, A. Dinculescu, L. Govindasamy, 2011, Molecular therapy : the journal of the American Society of Gene Therapy.

Gene therapy for female infertility: A farfetched dream or reality?

G. Jayandharan, Subhajit Pathak, Pratiksha Sarangi, 2022, Cell reports. Medicine.

Tyrosine-phosphorylation of AAV2 vectors and its consequences on viral intracellular trafficking and transgene expression.

N. Muzyczka, L. Govindasamy, M. Agbandje-McKenna, 2008, Virology.

The Adeno-Associated Virus Genome Packaging Puzzle.

Y. Wang, R. Samulski, N. Muzyczka, 2015, Journal of molecular and genetic medicine : an international journal of biomedical research.

Visualization of retinal morphology in rd12mice by scanning electron microscopy.

G. Jayandharan, B. Mary, 2019, Human gene therapy.

Human hepatocyte growth factor receptor is a cellular coreceptor for adeno-associated virus serotype 3.

Li Zhong, Binbin Cheng, Baozheng Li, 2010, Human gene therapy.

Molecular characterization of factor IX gene mutations in 53 patients with haemophilia B in India

M. Chandy, G. Jayandharan, S. Nair, 2005, Thrombosis and Haemostasis.

Polymorphisms in Coagulant and Inflammatory Genes Modify the Phenotype of Severe Hemophilia A and B.

A. Viswabandya, M. Chandy, V. Mathews, 2006 .

Safety of Adeno-associated virus-based vector-mediated gene therapy—impact of vector dose

G. Jayandharan, Shubham Maurya, Pratiksha Sarangi, 2022, Cancer Gene Therapy.

Mutations in coagulation factor XIII A gene in eight unrelated Indians

B. George, A. Viswabandya, M. Chandy, 2006, Thrombosis and Haemostasis.

Targeted delivery of miR125a-5p and human Factor VIII attenuates molecular mediators of hemophilic arthropathy.

G. Jayandharan, Pratiksha Sarangi, Senthilnathan Senguttuvan, 2023, Thrombosis research.

AAV mediated repression of Neat1 lncRNA combined with F8 gene augmentation mitigates pathological mediators of joint disease in haemophilia

G. Jayandharan, Narendra Kumar, Pratiksha Sarangi, 2024, Journal of cellular and molecular medicine.

AAV mediated genome engineering with a bypass coagulation factor alleviates the bleeding phenotype in a murine model of hemophilia B.

G. Jayandharan, Pratiksha Sarangi, Sonal Amit, 2024, Thrombosis Research.

Generation of two induced pluripotent stem cell lines (LVPEIi004-A and LVPEIi005-A) from probands with Leber Congenital Amaurosis 2 (LCA2) and harboring mutations in RPE65.

G. Jayandharan, S. Maddileti, C. Kannabiran, 2024, Stem cell research.