Ziying Yan

发表

Unique characteristics of AAV1, 2, and 5 viral entry, intracellular trafficking, and nuclear import define transduction efficiency in HeLa cells.

J. Engelhardt, N. Keiser, Ziying Yan, 2011, Human gene therapy.

Enhancement of Muscle Gene Delivery with Pseudotyped Adeno-Associated Virus Type 5 Correlates with Myoblast Differentiation

D. Duan, J. Engelhardt, Ziying Yan, 2001, Journal of Virology.

Ubiquitination of both Adeno-Associated Virus Type 2 and 5 Capsid Proteins Affects the Transduction Efficiency of Recombinant Vectors

J. Engelhardt, Ziying Yan, G. W. G. Luxton, 2002, Journal of Virology.

Adeno-associated Virus (AAV) Serotypes Have Distinctive Interactions with Domains of the Cellular AAV Receptor

M. S. Chapman, J. Carette, O. Davulcu, 2017, Journal of Virology.

Review for chiral-at-metal complexes and metal-organic framework enantiomorphs.

Ziying Yan, Xue-Bo Yin, Donghao Li, 2017, Science bulletin.

Dual therapeutic utility of proteasome modulating agents for pharmaco-gene therapy of the cystic fibrosis airway.

Huidong Shi, C. Caldwell, J. Engelhardt, 2004, Molecular therapy : the journal of the American Society of Gene Therapy.

Replication of an Autonomous Human Parvovirus in Non-dividing Human Airway Epithelium Is Facilitated through the DNA Damage and Repair Pathways

J. Qiu, J. Engelhardt, Ziying Yan, 2016, PLoS pathogens.

A new dual-vector approach to enhance recombinant adeno-associated virus-mediated gene expression through intermolecular cis activation

D. Duan, J. Engelhardt, Ziying Yan, 2000, Nature Medicine.

Targeted Correction of Single-Base-Pair Mutations with Adeno-Associated Virus Vectors under Nonselective Conditions

J. Engelhardt, Ziying Yan, R. Zák, 2004, Journal of Virology.

Inverted Terminal Repeat Sequences Are Important for Intermolecular Recombination and Circularization of Adeno-Associated Virus Genomes

J. Engelhardt, Ziying Yan, Yulong Zhang, 2005, Journal of Virology.

Aspm knockout ferret reveals an evolutionary mechanism governing cerebral cortical size

C. Walsh, J. Mandeville, X. Papademetris, 2018, Nature.

Lung phenotype of juvenile and adult cystic fibrosis transmembrane conductance regulator-knockout ferrets.

J. T. Fisher, D. Meyerholz, Z. A. Stewart, 2014, American journal of respiratory cell and molecular biology.

AAV-mediated gene editing lights up the lung.

J. Engelhardt, Ziying Yan, T. Lynch, 2021, Molecular therapy : the journal of the American Society of Gene Therapy.

Repeat Dosing of AAV2.5T to Ferret Lungs Elicits an Antibody Response That Diminishes Transduction in an Age-Dependent Manner

Xingshen Sun, J. Engelhardt, Ziying Yan, 2020, Molecular therapy. Methods & clinical development.

In utero and postnatal VX-770 administration rescues multiorgan disease in a ferret model of cystic fibrosis

P. Negulescu, F. van Goor, K. Gibson-Corley, 2019, Science Translational Medicine.

Abnormal endocrine pancreas function at birth in cystic fibrosis ferrets.

D. Meyerholz, Z. A. Stewart, Xingshen Sun, 2012, The Journal of clinical investigation.

Establishment of a Reverse Genetics System for Studying Human Bocavirus in Human Airway Epithelia

J. Qiu, M. Söderlund-Venermo, J. Engelhardt, 2012, PLoS pathogens.

Hepatocytes produce TNF-α following hypoxia-reoxygenation and liver ischemia-reperfusion in a NADPH oxidase- and c-Src-dependent manner.

J. Engelhardt, Ziying Yan, Yulong Zhang, 2013, American journal of physiology. Gastrointestinal and liver physiology.

Directing integrin-linked endocytosis of recombinant AAV enhances productive FAK-dependent transduction.

J. Engelhardt, N. Keiser, Ziying Yan, 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

Distinct Classes of Proteasome-Modulating Agents Cooperatively Augment Recombinant Adeno-Associated Virus Type 2 and Type 5-Mediated Transduction from the Apical Surfaces of Human Airway Epithelia

J. Engelhardt, Ziying Yan, Yulong Zhang, 2004, Journal of Virology.

Molecular characterization of suppression of hepatitis B virus transcription by hepatitis C virus core protein

Ziying Yan, Yunde Hou, Hailin Wang, 1997, Science in China Series C: Life Sciences.

Bioelectric properties of chloride channels in human, pig, ferret, and mouse airway epithelia.

J. Engelhardt, Ziying Yan, W. Ding, 2007, American journal of respiratory cell and molecular biology.

Expanding the capacity of AAV vectors

D. Duan, J. Engelhardt, Ziying Yan, 2005 .

Analysis of adeno-associated virus progenitor cell transduction in mouse lung.

J. Engelhardt, Ziying Yan, Diana C. M. Lei-Butters, 2009, Molecular therapy : the journal of the American Society of Gene Therapy.

rAAV-MEDIATED EDITING OF THE G551D CFTR MUTATION IN FERRET AIRWAY BASAL CELLS.

Xingshen Sun, Ziying Yan, Yulong Zhang, 2022, Human gene therapy.

A novel liver-directed gene delivery system using an autonomously replicating vector specifically expressed in AFP positive hepatoma cells

Ziying Yan, Huiyu Gong, J. Qiao, 1998, Science in China Series C: Life Sciences.

Human Bocavirus 1 Infection of Well‐Differentiated Human Airway Epithelium

J. Qiu, Ziying Yan, Xuefeng Deng, 2020, Current protocols in microbiology.

In Vitro Modeling of Human Bocavirus 1 Infection of Polarized Primary Human Airway Epithelia

J. Qiu, J. Engelhardt, Ziying Yan, 2013, Journal of Virology.

Spliceosome-mediated RNA trans-splicing with recombinant adeno-associated virus partially restores cystic fibrosis transmembrane conductance regulator function to polarized human cystic fibrosis airway epithelial cells.

L. Mitchell, J. Engelhardt, Ziying Yan, 2005, Human gene therapy.

A novel recombinant adeno-associated virus vector packaging system with HSV-1 amplicon providing helper functions

Y. Shu, Ziying Yan, Huiyu Gong, 1999, Science in China Series C: Life Sciences.

Recombinant AAV-mediated gene delivery using dual vector heterodimerization.

D. Duan, J. Engelhardt, Ziying Yan, 2002, Methods in enzymology.

A novel package system based on an EBV replicon vector for producing high titer recombinant adeno-associated virus vector

Y. Shu, Ziying Yan, Tong Zhang, 1997 .

The small nonstructural protein NP1 of human bocavirus 1 directly interacts with Ku70 and RPA70 and facilitates viral DNA replication

J. Qiu, Ziying Yan, Zekun Wang, 2022, PLoS pathogens.

Ferret and pig models of cystic fibrosis: prospects and promise for gene therapy.

J. Olsen, Z. A. Stewart, P. Sinn, 2014, Human gene therapy. Clinical development.

Highly Efficient Transgenesis in Ferrets Using CRISPR/Cas9-Mediated Homology-Independent Insertion at the ROSA26 Locus

S. Tyler, Xingshen Sun, J. Engelhardt, 2019, Scientific Reports.

Dual reporter comparative indexing of rAAV pseudotyped vectors in chimpanzee airway.

T. Flotte, L. Cebotaru, James M. Wilson, 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

Viral Vectors, Animal Models, and Cellular Targets for Gene Therapy of Cystic Fibrosis Lung Disease.

J. Engelhardt, Ziying Yan, Yinghua Tang, 2020, Human gene therapy.

Adeno-associated virus-targeted disruption of the CFTR gene in cloned ferrets.

Xingshen Sun, J. Engelhardt, Ziying Yan, 2008, The Journal of clinical investigation.

The SARS-CoV-2 Transcriptome and the Dynamics of the S Gene Furin Cleavage Site in Primary Human Airway Epithelia

J. Qiu, Ziying Yan, M. Salathe, 2021, bioRxiv.

Genetic Engineering in the Ferret

Xingshen Sun, J. Engelhardt, Ziying Yan, 2014 .

Detargeting Lentiviral-Mediated CFTR Expression in Airway Basal Cells Using miR-106b

E. Devor, J. Engelhardt, D. Stoltz, 2020, Genes.

Parvovirus Expresses a Small Noncoding RNA That Plays an Essential Role in Virus Replication

J. Qiu, J. Engelhardt, Ziying Yan, 2017, Journal of Virology.

Novel Chimeric Gene Therapy Vectors Based on Adeno-Associated Virus and Four Different Mammalian Bocaviruses

H. Clevers, D. Grimm, M. Meister, 2019, Molecular therapy. Methods & clinical development.

Production of CFTR-null and CFTR-DeltaF508 heterozygous pigs by adeno-associated virus-mediated gene targeting and somatic cell nuclear transfer.

M. Welsh, L. Spate, C. Murphy, 2008, The Journal of clinical investigation.

Gastrointestinal pathology in juvenile and adult CFTR-knockout ferrets.

Samuel I. Miller, L. Hoffman, H. Hayden, 2014, The American journal of pathology.

Disease phenotype of a ferret CFTR-knockout model of cystic fibrosis.

David K Meyerholz, Yaling Yi, Hyung-Ju Cho, 2010, The Journal of clinical investigation.

Establishment of a Recombinant AAV2/HBoV1 Vector Production System in Insect Cells

J. Qiu, Ziying Yan, W. Zou, 2020, Genes.

Development of a Novel Recombinant Adeno-Associated Virus Production System Using Human Bocavirus 1 Helper Genes

J. Qiu, J. Engelhardt, Ziying Yan, 2018, Molecular therapy. Methods & clinical development.

A novel chimeric adenoassociated virus 2/human bocavirus 1 parvovirus vector efficiently transduces human airway epithelia.

J. Qiu, J. Engelhardt, N. Keiser, 2013, Molecular therapy : the journal of the American Society of Gene Therapy.

Human Parvovirus Infection of Human Airway Epithelia Induces Pyroptotic Cell Death by Inhibiting Apoptosis

S. Ye, J. Qiu, J. Engelhardt, 2017, Journal of Virology.

Control of Hepatic Nuclear Superoxide Production by Glucose 6-Phosphate Dehydrogenase and NADPH Oxidase-4*

A. Shah, J. Engelhardt, Ziying Yan, 2011, The Journal of Biological Chemistry.

Adeno-Associated Virus Monoinfection Induces a DNA Damage Response and DNA Repair That Contributes to Viral DNA Replication

J. Qiu, Ziying Yan, Fang Cheng, 2023, mBio.

DNA Damage Signaling Is Required for Replication of Human Bocavirus 1 DNA in Dividing HEK293 Cells

J. Qiu, J. Engelhardt, P. Xu, 2016, Journal of Virology.

Second-Strand Genome Conversion of Adeno-Associated Virus Type 2 (AAV-2) and AAV-5 Is Not Rate Limiting following Apical Infection of Polarized Human Airway Epithelia

J. Engelhardt, Ziying Yan, W. Ding, 2003, Journal of Virology.

A Comprehensive RNA-seq Analysis of Human Bocavirus 1 Transcripts in Infected Human Airway Epithelium

J. Qiu, J. Engelhardt, Ziying Yan, 2019, Viruses.

Species-specific differences in mouse and human airway epithelial biology of recombinant adeno-associated virus transduction.

J. Engelhardt, Ziying Yan, Xiaoming Liu, 2006, American journal of respiratory cell and molecular biology.

Advances In Gene Therapy For Cystic Fibrosis Lung Disease.

J. Engelhardt, Ziying Yan, Paul B. McCray Jr., 2019, Human molecular genetics.

Long-Term Modeling of SARS-CoV-2 Infection of In Vitro Cultured Polarized Human Airway Epithelium

J. Qiu, Ziying Yan, K. Ning, 2020, mBio.

Human Bocavirus Type-1 Capsid Facilitates the Transduction of Ferret Airways by Adeno-Associated Virus Genomes.

J. Qiu, Xingshen Sun, J. Engelhardt, 2017, Human gene therapy.

Indexing TNF-α gene expression using a gene-targeted reporter cell line

J. Engelhardt, Ziying Yan, Diana C. M. Lei-Butters, 2009, BMC Biology.

Long Period Modeling SARS-CoV-2 Infection of in Vitro Cultured Polarized Human Airway Epithelium

J. Qiu, Ziying Yan, K. Ning, 2020, bioRxiv.

Mechanism of recombinant adeno-associated virus transduction

D. Duan, J. Engelhardt, Ziying Yan, 2005 .

Hairpin Transfer-Independent Parvovirus DNA Replication Produces Infectious Virus

J. Qiu, J. Engelhardt, Ziying Yan, 2021, Journal of virology.

Human Bocavirus 1 Is a Novel Helper for Adeno-associated Virus Replication

J. Qiu, J. Engelhardt, Ziying Yan, 2017, Journal of Virology.

Analysis of cis and trans Requirements for DNA Replication at the Right-End Hairpin of the Human Bocavirus 1 Genome

J. Qiu, J. Engelhardt, Ziying Yan, 2016, Journal of Virology.

Identification and Functional Analysis of Novel Nonstructural Proteins of Human Bocavirus 1

J. Qiu, J. Engelhardt, Ziying Yan, 2015, Journal of Virology.

Virus-Mediated Transduction of Murine Retina with Adeno-Associated Virus: Effects of Viral Capsid and Genome Size

R. Kotin, B. Davidson, J. Engelhardt, 2002, Journal of Virology.

Ferret models of alpha-1 antitrypsin deficiency develop lung and liver disease

E. Hoffman, Junfeng Guo, C. Mueller, 2022, JCI insight.

Nonstructural Protein NP1 of Human Bocavirus 1 Plays a Critical Role in the Expression of Viral Capsid Proteins

J. Qiu, J. Engelhardt, Ziying Yan, 2016, Journal of Virology.

Immunosuppression reduces rAAV2.5T neutralizing antibodies that limit efficacy following repeat dosing to ferret lungs

J. Engelhardt, Ziying Yan, R. Kolbeck, 2023, Molecular therapy. Methods & clinical development.

Optimization of Recombinant Adeno-Associated Virus-Mediated Expression for Large Transgenes, Using a Synthetic Promoter and Tandem Array Enhancers.

Z. A. Stewart, Xingshen Sun, J. Engelhardt, 2015, Human gene therapy.

Efficiency of chimeraplast gene targeting by direct nuclear injection using a GFP recovery assay.

Curt D Sigmund, Eric B Kmiec, E. Kmiec, 2003, Molecular therapy : the journal of the American Society of Gene Therapy.

CFTR gene transfer with AAV improves early cystic fibrosis pig phenotypes.

D. Schaffer, M. Welsh, L. Powers, 2016, JCI insight.

Postentry processing of recombinant adeno-associated virus type 1 and transduction of the ferret lung are altered by a factor in airway secretions.

S. Tyler, Xingshen Sun, J. Engelhardt, 2013, Human gene therapy.

Comparative Processing and Function of Human and Ferret Cystic Fibrosis Transmembrane Conductance Regulator*

G. Lukács, Yulong Zhang, J. Engelhardt, 2012, The Journal of Biological Chemistry.

Biological Differences in rAAV Transduction of Airway Epithelia in Humans and in Old World Non-human Primates.

W. Guggino, J. Engelhardt, Ziying Yan, 2007, Molecular therapy : the journal of the American Society of Gene Therapy.

Unique Biologic Properties of Recombinant AAV1 Transduction in Polarized Human Airway Epithelia*

J. Engelhardt, Ziying Yan, Yulong Zhang, 2006, Journal of Biological Chemistry.

Formation of Adeno-Associated Virus Circular Genomes Is Differentially Regulated by Adenovirus E4 ORF6 and E2a Gene Expression

Rachael A. Lester, Y. Ye, Prerna Sharma, 1999, Journal of Virology.

SCREEN FOR DOMINANT BEHAVIORAL MUTATIONS CAUSED BY GENOMIC INSERTION OF P-ELEMENT TRANSPOSONS IN DROSOPHILA: AN EXAMINATION OF THE INTEGRATION OF VIRAL VECTOR SEQUENCES

L. Fox, J. Engelhardt, Ziying Yan, 2007, Journal of neurogenetics.

Definitive localization of intracellular proteins: Novel approach using CRISPR-Cas9 genome editing, with glucose 6-phosphate dehydrogenase as a model.

Le Cong, J. Engelhardt, Ziying Yan, 2016, Analytical biochemistry.

A Preclinical Study in Rhesus Macaques for Cystic Fibrosis to Assess Gene Transfer and Transduction by AAV1 and AAV5 with a Dual-Luciferase Reporter System.

T. Conlon, J. Seagrave, L. Cebotaru, 2017, Human gene therapy. Clinical development.

Glandular Proteome Identifies Antiprotease Cystatin C as a Critical Modulator of Airway Hydration and Clearance.

N. Joo, J. Wine, S. Tyler, 2016, American journal of respiratory cell and molecular biology.

Effect of waste ceramic adsorbent on wastewater treatment

Jingying Liang, Ziying Yan, Jiachen Liu, 2018 .

Cellular Cleavage and Polyadenylation Specificity Factor 6 (CPSF6) Mediates Nuclear Import of Human Bocavirus 1 NP1 Protein and Modulates Viral Capsid Protein Expression

J. Qiu, J. Engelhardt, Xiaomei Wang, 2019, Journal of Virology.

Hybrid adeno-associated virus bearing nonhomologous inverted terminal repeats enhances dual-vector reconstruction of minigenes in vivo.

J. Engelhardt, Ziying Yan, Yulong Zhang, 2006, Human gene therapy.

Endosomal processing limits gene transfer to polarized airway epithelia by adeno-associated virus.

D. Duan, J. Engelhardt, Ziying Yan, 2000, The Journal of clinical investigation.

Establishment of a High-Yield Recombinant Adeno-Associated Virus/Human Bocavirus Vector Production System Independent of Bocavirus Nonstructural Proteins.

J. Qiu, J. Engelhardt, Ziying Yan, 2019, Human gene therapy.

Disease phenotype of a ferret CFTR-knockout model of cystic fibrosis.

N. Joo, J. Wine, D. Meyerholz, 2010, The Journal of clinical investigation.

Transgenic ferret models define pulmonary ionocyte diversity and function

Adam L. Haber, N. Joo, J. Wine, 2023, Nature.

Ferret and pig models of cystic fibrosis: prospects and promise for gene therapy.

J. Olsen, Z. A. Stewart, P. Sinn, 2014, Human gene therapy. Clinical development.

Adeno-associated virus-targeted disruption of the CFTR gene in cloned ferrets.

Xingshen Sun, J. Engelhardt, Ziying Yan, 2008, The Journal of clinical investigation.

Distinct Transduction Difference Between Adeno-Associated Virus Type 1 and Type 6 Vectors in Human Polarized Airway Epithelia

J. Engelhardt, N. Keiser, Ziying Yan, 2012, Gene Therapy.

Intracellular trafficking of adeno-associated viral vectors

J. Engelhardt, L. Zhang, Ziying Yan, 2005, Gene Therapy.

Polarity influences the efficiency of recombinant adenoassociated virus infection in differentiated airway epithelia.

J. Engelhardt, Ziying Yan, Z. Yan, 1998, Human gene therapy.

Indexing TNF-α gene expression using a gene-targeted reporter cell line

J. Engelhardt, Ziying Yan, Diana C. M. Lei-Butters, 2009, BMC Biology.

Human Bocavirus 1 Is a Novel Helper for Adeno-associated Virus Replication

J. Qiu, J. Engelhardt, Ziying Yan, 2017, Journal of Virology.

Analysis of cis and trans Requirements for DNA Replication at the Right-End Hairpin of the Human Bocavirus 1 Genome

J. Qiu, J. Engelhardt, Ziying Yan, 2016, Journal of Virology.

Nonstructural Protein NP1 of Human Bocavirus 1 Plays a Critical Role in the Expression of Viral Capsid Proteins

J. Qiu, J. Engelhardt, Ziying Yan, 2016, Journal of Virology.

DNA Damage Signaling Is Required for Replication of Human Bocavirus 1 DNA in Dividing HEK293 Cells

J. Qiu, J. Engelhardt, P. Xu, 2016, Journal of Virology.

SPECIAL FOCUS: PRECLINICAL STUDIES IN LARGE ANIMALS RESEARCH ARTICLES A Preclinical Study in Rhesus Macaques for Cystic Fibrosis to Assess Gene Transfer and Transduction by AAV1 and AAV5 with a Dual-Luciferase Reporter System

T. Conlon, J. Seagrave, L. Cebotaru, 2017 .

Trans-splicing vectors expand the utility of adeno-associated virus for gene therapy.

D. Duan, J. Engelhardt, Ziying Yan, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Structural analysis of adeno-associated virus transduction circular intermediates.

D. Duan, J. Engelhardt, Ziying Yan, 1999, Virology.

Durable transgene expression and efficient re-administration after rAAV2.5T-mediated fCFTRΔR gene delivery to adult ferret lungs

Ziying Yan, M. Limberis, J. Engelhardt, 2024, Molecular therapy. Methods & clinical development.

In utero and postnatal ivacaftor/lumacaftor therapy rescues multiorgan disease in CFTR-F508del ferrets

Xingshen Sun, Ziying Yan, D. Limoli, 2024, JCI insight.

In Vitro Modeling of Human Bocavirus 1 Infection of Polarized Primary Human Airway Epithelia

J. Qiu, J. Engelhardt, Ziying Yan, 2013, Journal of Virology.

Hepatocytes produce TNF-α following hypoxia-reoxygenation and liver ischemia-reperfusion in a NADPH oxidase- and c-Src-dependent manner.

J. Engelhardt, Ziying Yan, Yulong Zhang, 2013, American journal of physiology. Gastrointestinal and liver physiology.