B. Leuchs

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Uncoating Occurs in the Nucleus through the Cytoplasm and Are Maintained Domains Are Generated prior to Passage with Externalized VP 1 / VP 2 Trafficking Adeno-Associated Virus Type 2 Capsids

J. Kleinschmidt, F. Sonntag, S. Bleker, 2006 .

Adeno-Associated Virus Type 2 Capsids with Externalized VP1/VP2 Trafficking Domains Are Generated prior to Passage through the Cytoplasm and Are Maintained until Uncoating Occurs in the Nucleus

J. Kleinschmidt, F. Sonntag, S. Bleker, 2006, Journal of Virology.

Moving oncolytic viruses into the clinic: clinical-grade production, purification, and characterization of diverse oncolytic viruses

M. Coffey, D. Nettelbeck, J. Bell, 2016, Molecular therapy. Methods & clinical development.

Oncolytic effects of parvovirus H-1 in medulloblastoma are associated with repression of master regulators of early neurogenesis

S. Pfister, T. Hielscher, H. Witt, 2013, International journal of cancer.

Rapid and highly efficient inducible cardiac gene knockout in adult mice using AAV-mediated expression of Cre recombinase.

A. Nordheim, H. Katus, J. Backs, 2014, Cardiovascular research.

Parvovirus H1 selectively induces cytotoxic effects on human neuroblastoma cells

O. Witt, A. Kulozik, B. Leuchs, 2010, International journal of cancer.

TLR-9 Contributes to the Antiviral Innate Immune Sensing of Rodent Parvoviruses MVMp and H-1PV by Normal Human Immune Cells

T. Giese, N. Giese, R. Zawatzky, 2013, PloS one.

Heart-targeted adeno-associated viral vectors selected by in vivo biopanning of a random viral display peptide library

H. Katus, J. Kleinschmidt, O. Müller, 2010, Gene Therapy.

Angiotensin-converting enzyme inhibitors and beta-blockers in long-term treatment of dilated cardiomyopathy.

E. Fleck, V. Regitz-Zagrosek, B. Leuchs, 1995, American heart journal.

Upstream process optimization and micro- and macrocarrier screening for large-scale production of the oncolytic H-1 protoparvovirus

B. Leuchs, D. Wohlfarth, M. Vogel, 2021, Applied Microbiology and Biotechnology.

Intranasal vaccination with AAV5 and 9 vectors against human papillomavirus type 16 in rhesus macaques.

J. Kleinschmidt, B. Leuchs, L. Gissmann, 2012, Human gene therapy.

Molecular characterization of a genetically unstable region containing the SMS critical area and a breakpoint cluster for human PNETs.

A. Poustka, P. Lichter, B. Leuchs, 1997, Genomics.

Oncolytic H-1 Parvovirus Shows Safety and Signs of Immunogenic Activity in a First Phase I/IIa Glioblastoma Trial

A. Unterberg, A. Bartsch, A. von Deimling, 2017, Molecular therapy : the journal of the American Society of Gene Therapy.

Preclinical Testing of an Oncolytic Parvovirus in Ewing Sarcoma: Protoparvovirus H-1 Induces Apoptosis and Lytic Infection In Vitro but Fails to Improve Survival In Vivo

Z. Kis, B. Leuchs, J. Rommelaere, 2018, Viruses.

Intranasal Vaccination with Recombinant Adeno-Associated Virus Type 5 against Human Papillomavirus Type 16 L1

J. Kleinschmidt, B. Leuchs, D. Kuck, 2006, Journal of Virology.

Various effects of AAV9-mediated βARKct gene therapy on the heart in dystrophin-deficient (mdx) mice and δ-sarcoglycan-deficient (Sgcd-/-) mice

W. Koch, P. Most, H. Katus, 2019, Neuromuscular Disorders.

TSC22D4 is a molecular output of hepatic wasting metabolism

N. Gretz, Allan Jones, Philipp Kulozik, 2013, EMBO molecular medicine.

Focal delivery of AAV2/1-transgenes into the rat brain by localized ultrasound-induced BBB Opening.

M. Hennerici, S. Meairs, M. Fatar, 2014, Annals of neurosciences.

Focal Delivery of AAV2/1-transgenes Into the Rat Brain by Localized Ultrasound-induced BBB Opening

M. Hennerici, S. Meairs, M. Fatar, 2013, Molecular therapy. Nucleic acids.

Improved cardiac gene transfer by transcriptional and transductional targeting of adeno-associated viral vectors.

D. Grimm, H. Katus, J. Kleinschmidt, 2006, Cardiovascular research.

Protocol for efficient generation and characterization of adeno-associated viral (AAV) vectors.

H. Katus, O. Müller, B. Leuchs, 2017, Human gene therapy methods.

Protocol for Efficient Generation and Characterization of Adeno-Associated Viral Vectors.

H. Katus, O. Müller, B. Leuchs, 2017, Human gene therapy methods.

Myocardial catecholamine concentrations in dilated cardiomyopathy and heart failure of different origins.

E. Fleck, B. Leuchs, J. Sehested, 1991, European heart journal.

Phase I/IIa study of intratumoral/intracerebral or intravenous/intracerebral administration of Parvovirus H-1 (ParvOryx) in patients with progressive primary or recurrent glioblastoma multiforme: ParvOryx01 protocol

M. von Knebel Doeberitz, B. Leuchs, J. Rommelaere, 2012, BMC Cancer.

Arming parvoviruses with CpG motifs to improve their oncosuppressive capacity

M. Aprahamian, B. Leuchs, J. Rommelaere, 2008, International journal of cancer.

Manufacturing and characterization of a recombinant adeno-associated virus type 8 reference standard material.

L. Zentilin, M. Giacca, L. Tenenbaum, 2014, Human gene therapy.

Combined prophylactic and therapeutic intranasal vaccination against human papillomavirus type-16 using different adeno-associated virus serotype vectors

J. Kleinschmidt, B. Leuchs, L. Gissmann, 2009, Antiviral therapy.

Comparison of IL-10 and MCP-1-7ND gene transfer with AAV9 vectors for protection from murine autoimmune myocarditis.

H. Katus, O. Müller, B. Leuchs, 2011, Cardiovascular research.

Characterization of a recombinant adeno-associated virus type 2 Reference Standard Material.

Terence R Flotte, Hiroaki Mizukami, Mauro Giacca, 2010, Human gene therapy.

A novel scalable, robust downstream process for oncolytic rat parvovirus: isoelectric point-based elimination of empty particles

B. Leuchs, J. Rommelaere, Veronika Frehtman, 2017, Applied Microbiology and Biotechnology.

Killing of p53-deficient hepatoma cells by parvovirus H-1 and chemotherapeutics requires promyelocytic leukemia protein.

P. Galle, M. Schuler, B. Leuchs, 2008, World journal of gastroenterology.

Screening of Human Tumor Antigens for CD4+ T Cell Epitopes by Combination of HLA-Transgenic Mice, Recombinant Adenovirus and Antigen Peptide Libraries

D. Schadendorf, S. Eichmüller, T. Tüting, 2010, PloS one.

Temporal multi-omics identifies LRG1 as a vascular niche instructor of metastasis

Shubhada R. Kulkarni, Junhao Hu, E. Besemfelder, 2021, Science Translational Medicine.

Preclinical Testing of an Oncolytic Parvovirus: Standard Protoparvovirus H-1PV Efficiently Induces Osteosarcoma Cell Lysis In Vitro

Z. Kis, B. Leuchs, J. Rommelaere, 2017, Viruses.

Standardized large-scale H-1PV production process with efficient quality and quantity monitoring.

B. Leuchs, J. Rommelaere, K. Kürschner, 2016, Journal of virological methods.

Phase 2 Trial of Oncolytic H-1 Parvovirus Therapy Shows Safety and Signs of Immune System Activation in Patients With Metastatic Pancreatic Ductal Adenocarcinoma

N. Halama, D. Jäger, M. Kieser, 2021, Clinical Cancer Research.

A non-controlled, single arm, open label, phase II study of intravenous and intratumoral administration of ParvOryx in patients with metastatic, inoperable pancreatic cancer: ParvOryx02 protocol

N. Halama, D. Jäger, A. Stenzinger, 2017, BMC Cancer.

Cardiac AAV9-S100A1 Gene Therapy Rescues Post-Ischemic Heart Failure in a Preclinical Large Animal Model

P. Boekstegers, W. Koch, P. Most, 2011, Science Translational Medicine.

A Hepatic GAbp-AMPK Axis Links Inflammatory Signaling to Systemic Vascular Damage.

H. Hammes, N. Gretz, M. Conkright, 2017, Cell reports.

Fluorescence In Situ Hybridization (FISH) Detection of Viral Nucleic Acids in Oncolytic H-1 Parvovirus-Treated Human Brain Tumors.

B. Leuchs, J. Rommelaere, A. Angelova, 2020, Methods in molecular biology.

Identification of NY‐BR‐1‐specific CD4+ T cell epitopes using HLA‐transgenic mice

C. von Kalle, A. Schneeweiss, N. Halama, 2015, International journal of cancer.

Pediatric and Adult High-Grade Glioma Stem Cell Culture Models Are Permissive to Lytic Infection with Parvovirus H-1

T. Hielscher, O. Witt, S. Bender, 2016, Viruses.

Bioavailability, biodistribution, and CNS toxicity of clinical-grade parvovirus H1 after intravenous and intracerebral injection in rats.

B. Leuchs, J. Rommelaere, K. Geletneky, 2015, Comparative medicine.

Pathology, organ distribution, and immune response after single and repeated intravenous injection of rats with clinical-grade parvovirus H1.

B. Leuchs, J. Rommelaere, K. Geletneky, 2015, Comparative medicine.

Retargeting of Rat Parvovirus H-1PV to Cancer Cells through Genetic Engineering of the Viral Capsid

D. Nettelbeck, J. Kleinschmidt, B. Leuchs, 2012, Journal of Virology.

Oncolytic murine autonomous parvovirus, a candidate vector for glioma gene therapy, is innocuous to normal and immunocompetent mouse glial cells

B. Leuchs, J. Rommelaere, A. Régnier-Vigouroux, 2006, Cell and Tissue Research.

Human Retrotransposons and the Global Shutdown of Homeostatic Innate Immunity by Oncolytic Parvovirus H-1PV in Pancreatic Cancer

T. Giese, Andrea S Bauer, A. Heller, 2021, Viruses.

Improvement of Gemcitabine-Based Therapy of Pancreatic Carcinoma by Means of Oncolytic Parvovirus H-1PV

N. Giese, A. Hajri, M. Aprahamian, 2009, Clinical Cancer Research.

Activation of the human immune system by chemotherapeutic or targeted agents combined with the oncolytic parvovirus H-1

P. Galle, B. Leuchs, J. Rommelaere, 2011, BMC Cancer.

Cardiac AAV 9S 100 A 1 gene therapy rescues postischemic heart failure in a preclinical large animal model

P. Boekstegers, W. Koch, P. Most, 2014 .

Regression of Glioma in Rat Models by Intranasal Application of Parvovirus H-1

B. Leuchs, J. Rommelaere, J. Schlehofer, 2011, Clinical Cancer Research.

SUMOylation Targets Adeno-associated Virus Capsids but Mainly Restricts Transduction by Cellular Mechanisms

J. Kleinschmidt, S. Chiocca, B. Leuchs, 2020, Journal of Virology.

Interferon γ improves the vaccination potential of oncolytic parvovirus H-1PV for the treatment of peritoneal carcinomatosis in pancreatic cancer

T. Giese, A. Heller, N. Giese, 2011, Cancer biology & therapy.

Stability and safety key factors of the oncolytic protoparvovirus H-1 from manufacturing to human application

B. Leuchs, D. Wohlfarth, O. Krebs, 2023, Applied Microbiology and Biotechnology.

A novel scalable, robust downstream process for oncolytic rat parvovirus: isoelectric point-based elimination of empty particles

B. Leuchs, J. Rommelaere, Veronika Frehtman, 2017, Applied Microbiology and Biotechnology.

Temporal multi-omics identifies LRG1 as a vascular 1 niche instructor of metastatic colonization

Junhao Hu, E. Besemfelder, H. Augustin, 2019 .

Genomic CpG enrichment of oncolytic parvoviruses as a potent anticancer vaccination strategy for the treatment of pancreatic adenocarcinoma

T. Giese, A. Heller, N. Giese, 2014 .

Novel adenovirus-based helper system to support production of recombinant parvovirus

B. Leuchs, J. Kleinschmidt, A. Marchini, 2011, Cancer Gene Therapy.

Rapid and highly efficient inducible cardiac gene knockout in adult mice using AAV-mediated expression of Cre recombinase.

A. Nordheim, H. Katus, J. Backs, 2014, Cardiovascular research.

Cardiac AAV9-S100A1 Gene Therapy Rescues Post-Ischemic Heart Failure in a Preclinical Large Animal Model

P. Boekstegers, W. Koch, P. Most, 2011, Science Translational Medicine.

Focal Delivery of AAV2/1-transgenes Into the Rat Brain by Localized Ultrasound-induced BBB Opening

M. Hennerici, S. Meairs, M. Fatar, 2013, Molecular therapy. Nucleic acids.

Comparison of IL-10 and MCP-1-7ND gene transfer with AAV9 vectors for protection from murine autoimmune myocarditis.

H. Katus, O. Müller, B. Leuchs, 2011, Cardiovascular research.

Retargeting of Rat Parvovirus H-1PV to Cancer Cells through Genetic Engineering of the Viral Capsid

D. Nettelbeck, J. Kleinschmidt, B. Leuchs, 2012, Journal of Virology.

Characterization of a recombinant adeno-associated virus type 2 Reference Standard Material.

L. Zentilin, M. Giacca, T. Conlon, 2010, Human gene therapy.

H-1 Parvovirus-Induced Oncolysis and Tumor Microenvironment Immune Modulation in a Novel Heterotypic Spheroid Model of Cutaneous T-Cell Lymphoma

B. Leuchs, A. Angelova, Milena Barf, 2024, Cancers.

Efficient recombinant parvovirus production with the help of adenovirus-derived systems.

B. Leuchs, A. Marchini, J. Rommelaere, 2012, Journal of visualized experiments : JoVE.