A. Delpal

发表

Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity

N. Seidah, B. Coutard, Ursula Andréo, 2022, Journal of virology.

The spîke (S)-protein of SARS-CoV-2 binds ACE2 and requires proteolytic “priming” at PRRAR685↓

N. Seidah, B. Coutard, Ursula Andréo, 2021 .

Implications of Spike-glycoprotein processing at S1/S2 by Furin, at S2’ by Furin and/or TMPRSS2 and shedding of ACE2: cell-to-cell fusion, cell entry and infectivity of SARS-CoV-2

N. Seidah, B. Coutard, Ursula Andréo, 2020, bioRxiv.

Implications of Spike-glycoprotein processing at S1/S2 by Furin, at S2’ by Furin and/or TMPRSS2 and shedding of ACE2: cell-to-cell fusion, cell entry and infectivity of SARS-CoV-2

N. Seidah, B. Coutard, Ursula Andréo, 2020, bioRxiv.

Synthesis, Structure–Activity Relationships, and Antiviral Profiling of 1-Heteroaryl-2-Alkoxyphenyl Analogs as Inhibitors of SARS-CoV-2 Replication

A. Marchand, R. Hilgenfeld, E. Decroly, 2022, Molecules.

Potent Inhibition of SARS-CoV-2 nsp14 N7-Methyltransferase by Sulfonamide-Based Bisubstrate Analogues

B. Coutard, Priscila Sutto-Ortiz, E. Decroly, 2022, Journal of medicinal chemistry.

A Versatile Class of 1,4,4-Trisubstituted Piperidines Block Coronavirus Replication In Vitro

L. Naesens, F. Gago, E. Decroly, 2022, Pharmaceuticals.

A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase

E. Decroly, A. Delpal, B. Canard, 2021, Nature Communications.

Erratum for Essalmani et al., “Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity”

N. Seidah, B. Coutard, Ursula Andréo, 2022, Journal of Virology.

Furin cleaves SARS-CoV-2 spike-glycoprotein at S1/S2 and S2'for viral fusion/entry: indirect role for TMPRSS2

N. Seidah, B. Coutard, Ursula Andréo, 2020 .

Structure-guided optimization of adenosine mimetics as selective and potent inhibitors of coronavirus nsp14 N7-methyltransferases

B. Coutard, E. Decroly, A. Delpal, 2023, European Journal of Medicinal Chemistry.

Facile access to 4'-(N-acylsulfonamide) modified nucleosides and evaluation of their inhibitory activity against SARS-CoV-2 RNA cap N7-guanine-methyltransferase nsp14.

E. Decroly, A. Delpal, B. Canard, 2022, Organic & biomolecular chemistry.

A highly sensitive cell-based luciferase assay for high-throughput automated screening of SARS-CoV-2 nsp5/3CLpro inhibitors

C. Isel, E. Decroly, F. Agou, 2022, Antiviral Research.