V. Sepe

发表

Hijacking SARS-CoV-2/ACE2 Receptor Interaction by Natural and Semi-synthetic Steroidal Agents Acting on Functional Pockets on the Receptor Binding Domain

D. Francisci, A. Carino, Federica Moraca, 2020, Frontiers in Chemistry.

Total synthesis and pharmacological characterization of solomonsterol A, a potent marine pregnane-X-receptor agonist endowed with anti-inflammatory activity.

V. Sepe, A. Zampella, S. Fiorucci, 2011, Journal of medicinal chemistry.

Modification in the side chain of solomonsterol A: discovery of cholestan disulfate as a potent pregnane-X-receptor agonist.

G. Bifulco, V. Sepe, A. Zampella, 2012, Organic & biomolecular chemistry.

The First Total Synthesis of Solomonsterol B, a Marine Pregnane X Receptor Agonist

V. Sepe, A. Zampella, S. Fiorucci, 2012 .

Incisterols, highly degraded marine sterols, are a new chemotype of PXR agonists

V. Sepe, A. Zampella, S. Fiorucci, 2014, Steroids.

Insights on pregnane-X-receptor modulation. Natural and semisynthetic steroids from Theonella marine sponges.

E. Novellino, V. Sepe, A. Zampella, 2014, European journal of medicinal chemistry.

Towards new ligands of nuclear receptors. Discovery of malaitasterol A, an unique bis-secosterol from marine sponge Theonella swinhoei.

G. Bifulco, V. Sepe, A. Zampella, 2011, Organic & biomolecular chemistry.

Solomonsterol A, a Marine Pregnane-X-Receptor Agonist, Attenuates Inflammation and Immune Dysfunction in a Mouse Model of Arthritis

E. Perissutti, A. Carino, V. Sepe, 2013, Marine drugs.

Discovery of Bile Acid Derivatives as Potent ACE2 Activators by Virtual Screening and Essential Dynamics

A. Carino, Federica Moraca, S. Marchianò, 2021, J. Chem. Inf. Model..

Exploitation of cholane scaffold for the discovery of potent and selective farnesoid X receptor (FXR) and G-protein coupled bile acid receptor 1 (GP-BAR1) ligands.

A. Carino, V. Sepe, C. Finamore, 2014, Journal of medicinal chemistry.

Discovery of sulfated sterols from marine invertebrates as a new class of marine natural antagonists of farnesoid-X-receptor.

Giuseppe Bifulco, G. Bifulco, V. Sepe, 2011, Journal of medicinal chemistry.

Steroidal scaffolds as FXR and GPBAR1 ligands: from chemistry to therapeutical application.

V. Sepe, E. Distrutti, A. Zampella, 2015, Future medicinal chemistry.

Conicasterol E, a small heterodimer partner sparing farnesoid X receptor modulator endowed with a pregnane X receptor agonistic activity, from the marine sponge Theonella swinhoei.

G. Bifulco, V. Sepe, A. Zampella, 2012, Journal of medicinal chemistry.

Preliminary Structure-Activity Relationship on Theonellasterol, a New Chemotype of FXR Antagonist, from the Marine Sponge Theonella swinhoei

G. Bifulco, V. Sepe, A. Zampella, 2012, Marine drugs.

FXR mediates a chromatin looping in the GR promoter thus promoting the resolution of colitis in rodents.

A. Carino, V. Sepe, E. Distrutti, 2013, Pharmacological research.

Impaired Itching Perception in Murine Models of Cholestasis Is Supported by Dysregulation of GPBAR1 Signaling

A. Carino, V. Sepe, A. Zampella, 2015, PloS one.

Perthamides C-F, potent human antipsoriatic cyclopeptides

G. Bifulco, V. Sepe, A. Zampella, 2011 .

Concise synthesis of AHMHA unit in perthamide C. Structural and stereochemical revision of perthamide C

G. Bifulco, V. Sepe, A. Zampella, 2010 .

Homophymines B-E and A1-E1, a family of bioactive cyclodepsipeptides from the sponge Homophymia sp.

V. Sepe, A. Zampella, T. Cresteil, 2009, Organic & biomolecular chemistry.

Thiazolidin-4-one-based compounds interfere with the eicosanoid biosynthesis pathways by mPGES-1/sEH/5-LO multi-target inhibition

G. Bifulco, O. Werz, V. Sepe, 2022, European Journal of Medicinal Chemistry Reports.

Solomonamides A and B, new anti-inflammatory peptides from Theonella swinhoei.

G. Bifulco, V. Sepe, A. Zampella, 2011, Organic letters.

Perthamides C and D, two new potent anti-inflammatory cyclopeptides from a Solomon Lithistid sponge Theonella swinhoei

V. Sepe, A. Zampella, M. Monti, 2009 .

Stereochemical assignment of the C23–C35 portion of sphinxolide/reidispongiolide class of natural products by asymmetric synthesis

G. Bifulco, V. Sepe, A. Zampella, 2003 .

Isolation and structural elucidation of callipeltins J–M: antifungal peptides from the marine sponge Latrunculia sp.

V. Sepe, A. Zampella, M. V. D’Auria, 2007 .

Concise synthesis of all stereoisomers of beta-methoxytyrosine and determination of the absolute configuration of the residue in callipeltin A.

V. Sepe, A. Zampella, M. Monti, 2005, Organic letters.

Phallusiasterols A and B: Two New Sulfated Sterols from the Mediterranean Tunicate Phallusia fumigata and Their Effects as Modulators of the PXR Receptor

V. Sepe, S. Fiorucci, C. D’Amore, 2014, Marine drugs.

Homophymine A, an anti-HIV cyclodepsipeptide from the sponge Homophymia sp.

V. Sepe, A. Zampella, M. Monti, 2008, The Journal of organic chemistry.

Natural ligands for nuclear receptors: biology and potential therapeutic applications.

V. Sepe, A. Zampella, M. V. D’Auria, 2012, Current topics in medicinal chemistry.

Jaspamides M–P: new tryptophan modified jaspamide derivatives from the sponge Jaspis splendans

Charles D Smith, V. Sepe, A. Zampella, 2009 .

Callipeltins F–I: new antifungal peptides from the marine sponge Latrunculia sp.

G. Bifulco, A. Catania, V. Sepe, 2006 .

Solomonamides A and B, New Antiinflammatory Peptides from Theonella swinhoei.

G. Bifulco, V. Sepe, A. Zampella, 2011 .

Investigation on bile acid receptor regulators. Discovery of cholanoic acid derivatives with dual G-protein coupled bile acid receptor 1 (GPBAR1) antagonistic and farnesoid X receptor (FXR) modulatory activity

A. Carino, V. Sepe, C. Finamore, 2016, Steroids.

Navigation in bile acid chemical space: discovery of novel FXR and GPBAR1 ligands

A. Carino, S. Marchianò, V. Sepe, 2016, Scientific Reports.

Insights on FXR selective modulation. Speculation on bile acid chemical space in the discovery of potent and selective agonists

A. Carino, V. Sepe, C. Finamore, 2016, Scientific Reports.

Epoxide functionalization on cholane side chains in the identification of G-protein coupled bile acid receptor (GPBAR1) selective agonists

A. Carino, S. Marchianò, V. Sepe, 2017 .

Homogenization techniques for the analysis of porous SMA

E. Sacco, F. Auricchio, V. Sepe, 2016 .

Triterpenoid profile and bioactivity study of Oenothera maritima

J. Ilaš, V. Sepe, Carmen Festa, 2015 .

Identification of Cysteinyl-leukotriene-receptor 1 antagonists as ligands for the bile acid receptor GPBAR1.

A. Carino, S. Marchianò, V. Sepe, 2020, Biochemical pharmacology.

Repositioning Mifepristone as a Leukaemia Inhibitory Factor Receptor Antagonist for the Treatment of Pancreatic Adenocarcinoma

Federica Moraca, S. Marchianò, V. Sepe, 2022, Cells.

Novel Isoxazole Derivatives with Potent FXR Agonistic Activity Prevent Acetaminophen-Induced Liver Injury.

E. Novellino, A. Carino, S. Marchianò, 2018, ACS medicinal chemistry letters.

Discovery of a Potent and Orally Active Dual GPBAR1/CysLT1R Modulator for the Treatment of Metabolic Fatty Liver Disease

S. Marchianò, V. Sepe, Michele Biagioli, 2022, Frontiers in Pharmacology.

Targeting Bile Acid Receptors: Discovery of a Potent and Selective Farnesoid X Receptor Agonist as a New Lead in the Pharmacological Approach to Liver Diseases

S. Marchianò, V. Sepe, E. Distrutti, 2017, Front. Pharmacol..

Synthetic studies on homophymine A: stereoselective synthesis of (2R,3R,4R,6R)-3-hydroxy-2,4,6-trimethyloctanoic acid

V. Sepe, A. Zampella, M. V. D’Auria, 2009 .

Design, synthesis, and biological evaluation of potent dual agonists of nuclear and membrane bile acid receptors.

V. Sepe, A. Zampella, S. Fiorucci, 2014, Journal of medicinal chemistry.

Introduction of Nonacidic Side Chains on 6-Ethylcholane Scaffolds in the Identification of Potent Bile Acid Receptor Agonists with Improved Pharmacokinetic Properties

S. Marchianò, V. Sepe, C. Finamore, 2019, Molecules.

Discovery of a Novel Class of Dual GPBAR1 Agonists–RORγt Inverse Agonists for the Treatment of IL-17-Mediated Disorders

S. Marchianò, V. Sepe, Michele Biagioli, 2023, ACS omega.

Synthesis, pharmacological evaluation, and molecular modeling studies of novel peptidic CAAX analogues as farnesyl-protein-transferase inhibitors.

E. Novellino, A. Lavecchia, G. Caliendo, 2006, Journal of medicinal chemistry.

Chemistry and Pharmacology of GPBAR1 and FXR Selective Agonists, Dual Agonists, and Antagonists.

V. Sepe, A. Zampella, Carmen Festa, 2019, Handbook of experimental pharmacology.

Marine and Semi-Synthetic Hydroxysteroids as New Scaffolds for Pregnane X Receptor Modulation

E. Novellino, V. Sepe, A. Zampella, 2014, Marine drugs.

Modification on ursodeoxycholic acid (UDCA) scaffold. discovery of bile acid derivatives as selective agonists of cell-surface G-protein coupled bile acid receptor 1 (GP-BAR1).

E. Novellino, V. Sepe, A. Zampella, 2014, Journal of medicinal chemistry.

Jaspamides H–L, new actin-targeting depsipeptides from the sponge Jaspis splendans

Charles D Smith, V. Sepe, A. Zampella, 2008 .

Analysis of Gastric Cancer Transcriptome Allows the Identification of Histotype Specific Molecular Signatures With Prognostic Potential

S. Marchianò, V. Sepe, Michele Biagioli, 2021, bioRxiv.

Reduced order modeling in nonlinear homogenization

Sonia Marfia, Felix Fritzen, V. Sepe, 2015 .

A nonuniform TFA homogenization technique based on piecewise interpolation functions of the inelastic field

Sonia Marfia, Elio Sacco, E. Sacco, 2013 .

Discovery of BAR502, as potent steroidal antagonist of leukemia inhibitory factor receptor for the treatment of pancreatic adenocarcinoma

Federica Moraca, S. Marchianò, V. Sepe, 2023, Frontiers in Oncology.

The identification of farnesoid X receptor modulators as treatment options for nonalcoholic fatty liver disease

V. Sepe, Michele Biagioli, E. Distrutti, 2021, Expert opinion on drug discovery.

Farnesoid X receptor modulators 2014-present: a patent review

V. Sepe, E. Distrutti, A. Zampella, 2018, Expert opinion on therapeutic patents.

Farnesoid X receptor modulators (2011 – 2014): a patent review

V. Sepe, E. Distrutti, A. Zampella, 2015, Expert opinion on therapeutic patents.

Isolation and Structural Elucidation of Callipeltins J—M: Antifungal Peptides from the Marine Sponge Latrunculia sp.

V. Sepe, A. Zampella, M. V. D’Auria, 2007 .

Structural Basis for Developing Multitarget Compounds Acting on Cysteinyl Leukotriene Receptor 1 and G-Protein-Coupled Bile Acid Receptor 1.

S. Marchianò, V. Sepe, Michele Biagioli, 2021, Journal of medicinal chemistry.

Bile acid modulators for the treatment of nonalcoholic steatohepatitis (NASH)

V. Sepe, Michele Biagioli, E. Distrutti, 2020, Expert opinion on investigational drugs.

Structure-based drug design targeting the cell membrane receptor GPBAR1: exploiting the bile acid scaffold towards selective agonism

Ettore Novellino, Vittorio Limongelli, Francesco Saverio Di Leva, 2015, Scientific Reports.

Hijacking SARS-Cov-2/ACE2 receptor interaction by natural and semi-synthetic steroidal agents acting on functional pockets on receptor binding region

D. Francisci, Federica Moraca, S. Marchianò, 2020, bioRxiv.

Theonellasterone, a steroidal metabolite isolated from a Theonella sponge, protects peroxiredoxin-1 from oxidative stress reactions.

M. Mozzicafreddo, V. Sepe, A. Zampella, 2015, Chemical communications.

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

S. Marchianò, V. Sepe, Michele Biagioli, 2022 .

Synthetic and pharmacological studies on new simplified analogues of the potent actin-targeting Jaspamide.

G. Bifulco, Charles D Smith, V. Sepe, 2008, Bioorganic & medicinal chemistry.

Isolation of Plakinamine I: A New Steroidal Alkaloid from the Marine Sponge Corticium sp. and Synthesis of an Analogue Model Compound

V. Sepe, A. Zampella, M. V. D’Auria, 2005 .

Isolation of Plakinamine I: A New Steroidal Alkaloid from the Marine Sponge Corticium sp. and Synthesis of an Analogue Model Compound.

V. Sepe, A. Zampella, M. V. D’Auria, 2006 .

Discovery That Theonellasterol a Marine Sponge Sterol Is a Highly Selective FXR Antagonist That Protects against Liver Injury in Cholestasis

G. Bifulco, V. Sepe, A. Zampella, 2012, PloS one.

Development of bile acid activated receptors hybrid molecules for the treatment of inflammatory and metabolic disorders.

V. Sepe, Michele Biagioli, E. Distrutti, 2023, Biochemical pharmacology.

Bile Acids Serve As Endogenous Antagonists Of The Leukemia Inhibitory Factor (LIF) Receptor in Oncogenesis

S. Marchianò, V. Sepe, Michele Biagioli, 2023, bioRxiv.

Theonellasterone, a steroidal metabolite isolated from a Theonella sponge, protects peroxiredoxin-1 from oxidative stress reactions.

V. Sepe, A. Zampella, A. Tosco, 2015, Chemical communications.

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

S. Marchianò, V. Sepe, Michele Biagioli, 2022, Hepatology.

Development of dual GPBAR1 agonist and RORγt inverse agonist for the treatment of inflammatory bowel diseases

S. Marchianò, V. Sepe, Michele Biagioli, 2024, Pharmacological Research.