Michele Biagioli

发表

Hijacking SARS-CoV-2/ACE2 Receptor Interaction by Natural and Semi-synthetic Steroidal Agents Acting on Functional Pockets on the Receptor Binding Domain

D. Francisci, A. Carino, Federica Moraca, 2020, Frontiers in Chemistry.

Wnt/β-Catenin Signaling Induces Integrin α4β1 in T Cells and Promotes a Progressive Neuroinflammatory Disease in Mice

O. Britanova, E. Mazzon, P. Bramanti, 2017, The Journal of Immunology.

Discovery of Bile Acid Derivatives as Potent ACE2 Activators by Virtual Screening and Essential Dynamics

A. Carino, Federica Moraca, S. Marchianò, 2021, J. Chem. Inf. Model..

Divergent Effectiveness of Multispecies Probiotic Preparations on Intestinal Microbiota Structure Depends on Metabolic Properties

A. Carino, S. Marchianò, Michele Biagioli, 2019, Nutrients.

Atorvastatin protects against liver and vascular damage in a model of diet induced steatohepatitis by resetting FXR and GPBAR1 signaling

S. Marchianò, Michele Biagioli, E. Distrutti, 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Immunomodulatory functions of FXR

Michele Biagioli, E. Distrutti, A. Zampella, 2022, Molecular and Cellular Endocrinology.

Future trends in the treatment of non‐alcoholic steatohepatitis

Michele Biagioli, E. Distrutti, S. Fiorucci, 2018, Pharmacological research.

Gpbar1 agonism promotes a Pgc-1α-dependent browning of white adipose tissue and energy expenditure and reverses diet-induced steatohepatitis in mice

A. Carino, S. Marchianò, Michele Biagioli, 2017, Scientific Reports.

Glucocorticoid-induced leucine zipper regulates liver fibrosis by suppressing CCL2-mediated leukocyte recruitment

C. Riccardi, Michele Biagioli, G. Migliorati, 2021, Cell Death & Disease.

BAR502, a dual FXR and GPBAR1 agonist, promotes browning of white adipose tissue and reverses liver steatosis and fibrosis

A. Carino, S. Marchianò, Michele Biagioli, 2017, Scientific Reports.

Agonism for the bile acid receptor GPBAR1 reverses liver and vascular damage in a mouse model of steatohepatitis

A. Carino, S. Marchianò, Michele Biagioli, 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Discovery of a Novel Multi-Strains Probiotic Formulation with Improved Efficacy toward Intestinal Inflammation

A. Carino, S. Marchianò, Michele Biagioli, 2020, Nutrients.

Next-Generation Sequencing Analysis of Gastric Cancer Identifies the Leukemia Inhibitory Factor Receptor as a Driving Factor in Gastric Cancer Progression and as a Predictor of Poor Prognosis

S. Marchianò, Michele Biagioli, E. Distrutti, 2022, bioRxiv.

Lack of glucocorticoid-induced leucine zipper (GILZ) deregulates B-cell survival and results in B-cell lymphocytosis in mice.

E. Mazzon, C. Riccardi, Michele Biagioli, 2015, Blood.

The bile acid activated receptors GPBAR1 and FXR exert antagonistic effects on autophagy

A. Carino, S. Marchianò, Michele Biagioli, 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

GPBAR1 Functions as Gatekeeper for Liver NKT Cells and provides Counterregulatory Signals in Mouse Models of Immune-Mediated Hepatitis

A. Carino, S. Marchianò, Michele Biagioli, 2019, Cellular and molecular gastroenterology and hepatology.

Navigation in bile acid chemical space: discovery of novel FXR and GPBAR1 ligands

A. Carino, S. Marchianò, V. Sepe, 2016, Scientific Reports.

Signaling from Intestine to the Host: How Bile Acids Regulate Intestinal and Liver Immunity.

A. Carino, Michele Biagioli, Adriana Carino, 2019, Handbook of experimental pharmacology.

Beneficial effects of UDCA and norUDCA in a rodent model of steatosis are linked to modulation of GPBAR1/FXR signaling.

S. Marchianò, Michele Biagioli, E. Distrutti, 2022, Biochimica et biophysica acta. Molecular and cell biology of lipids.

Ursodeoxycholic acid is a GPBAR1 agonist and resets liver/intestinal FXR signaling in a model of diet-induced dysbiosis and NASH.

A. Carino, S. Marchianò, Michele Biagioli, 2019, Biochimica et biophysica acta. Molecular and cell biology of lipids.

Genetic and Pharmacological Dissection of the Role of Spleen Tyrosine Kinase (Syk) in Intestinal Inflammation and Immune Dysfunction in Inflammatory Bowel Diseases.

F. Baldelli, A. Carino, S. Marchianò, 2017, Inflammatory bowel diseases.

GPBAR1 Activation by C6-Substituted Hyodeoxycholane Analogues Protect against Colitis.

E. Novellino, A. Carino, S. Marchianò, 2020, ACS medicinal chemistry letters.

The Bile Acid Receptor GPBAR1 Modulates CCL2/CCR2 Signaling at the Liver Sinusoidal/Macrophage Interface and Reverses Acetaminophen-Induced Liver Toxicity

A. Carino, S. Marchianò, Michele Biagioli, 2020, The Journal of Immunology.

Opposite effects of the FXR agonist obeticholic acid on Mafg and Nrf2 mediate the development of acute liver injury in rodent models of cholestasis.

A. Carino, S. Marchianò, Michele Biagioli, 2020, Biochimica et biophysica acta. Molecular and cell biology of lipids.

Identification of Cysteinyl-leukotriene-receptor 1 antagonists as ligands for the bile acid receptor GPBAR1.

A. Carino, S. Marchianò, V. Sepe, 2020, Biochemical pharmacology.

Repositioning Mifepristone as a Leukaemia Inhibitory Factor Receptor Antagonist for the Treatment of Pancreatic Adenocarcinoma

Federica Moraca, S. Marchianò, V. Sepe, 2022, Cells.

Special FX: Harnessing the Farnesoid-X-Receptor to Control Bile Acid Synthesis

Michele Biagioli, E. Distrutti, S. Fiorucci, 2021, Digestive Diseases and Sciences.

Novel Isoxazole Derivatives with Potent FXR Agonistic Activity Prevent Acetaminophen-Induced Liver Injury.

E. Novellino, A. Carino, S. Marchianò, 2018, ACS medicinal chemistry letters.

Discovery of a Potent and Orally Active Dual GPBAR1/CysLT1R Modulator for the Treatment of Metabolic Fatty Liver Disease

S. Marchianò, V. Sepe, Michele Biagioli, 2022, Frontiers in Pharmacology.

Metabolic Variability of a Multispecies Probiotic Preparation Impacts on the Anti-inflammatory Activity

L. Laghi, S. Marchianò, Michele Biagioli, 2017, Front. Pharmacol..

Discovery of a Novel Class of Dual GPBAR1 Agonists–RORγt Inverse Agonists for the Treatment of IL-17-Mediated Disorders

S. Marchianò, V. Sepe, Michele Biagioli, 2023, ACS omega.

Bile Acid Signaling in Inflammatory Bowel Diseases

Michele Biagioli, E. Distrutti, S. Fiorucci, 2020, Digestive Diseases and Sciences.

Bile Acids Activated Receptors Regulate Innate Immunity

Michele Biagioli, E. Distrutti, A. Zampella, 2018, Front. Immunol..

GILZ promotes production of peripherally induced Treg cells and mediates the crosstalk between glucocorticoids and TGF-β signaling.

C. Riccardi, Michele Biagioli, S. Bruscoli, 2014, Cell reports.

Bile acid activated receptors: Integrating immune and metabolic regulation in non-alcoholic fatty liver disease

Michele Biagioli, S. Fiorucci, 2021, Liver Research.

Disruption of TFG&bgr;‐SMAD3 pathway by the nuclear receptor SHP mediates the antifibrotic activities of BAR704, a novel highly selective FXR ligand

S. Marchianò, Michele Biagioli, A. Zampella, 2018, Pharmacological research.

The Aryl Hydrocarbon Receptor (AhR) Mediates the Counter-Regulatory Effects of Pelargonidins in Models of Inflammation and Metabolic Dysfunctions

S. Marchianò, Michele Biagioli, E. Distrutti, 2019, Nutrients.

Bile Acids Activated Receptors in Inflammatory Bowel Disease

S. Marchianò, Michele Biagioli, E. Distrutti, 2021, Cells.

The Bile Acid Receptor GPBAR1 Regulates the M1/M2 Phenotype of Intestinal Macrophages and Activation of GPBAR1 Rescues Mice from Murine Colitis

D. Francisci, S. Marchianò, Michele Biagioli, 2017, The Journal of Immunology.

Bile acids and their receptors in metabolic disorders.

Michele Biagioli, E. Distrutti, A. Zampella, 2021, Progress in lipid research.

GLP-1 Mediates Regulation of Colonic ACE2 Expression by the Bile Acid Receptor GPBAR1 in Inflammation

S. Marchianò, Michele Biagioli, E. Distrutti, 2022, Cells.

Bile acid-activated receptors and the regulation of macrophages function in metabolic disorders.

Michele Biagioli, E. Distrutti, A. Zampella, 2020, Current opinion in pharmacology.

Discovery of a AHR pelargonidin agonist that counter-regulates Ace2 expression and attenuates ACE2-SARS-CoV-2 interaction

D. Francisci, S. Marchianò, Michele Biagioli, 2021, Biochemical Pharmacology.

Discovery of a AhR flavonoid agonist that counter-regulates ACE2 expression in rodent models of inflammation and attenuates ACE2-SARS-CoV2 interaction in vitro

D. Francisci, S. Marchianò, Michele Biagioli, 2021, bioRxiv.

Analysis of Gastric Cancer Transcriptome Allows the Identification of Histotype Specific Molecular Signatures With Prognostic Potential

S. Marchianò, V. Sepe, Michele Biagioli, 2021, bioRxiv.

Discovery of BAR502, as potent steroidal antagonist of leukemia inhibitory factor receptor for the treatment of pancreatic adenocarcinoma

Federica Moraca, S. Marchianò, V. Sepe, 2023, Frontiers in Oncology.

The identification of farnesoid X receptor modulators as treatment options for nonalcoholic fatty liver disease

V. Sepe, Michele Biagioli, E. Distrutti, 2021, Expert opinion on drug discovery.

Combinatorial therapy with BAR502 and UDCA resets FXR and GPBAR1 signaling and reverses liver histopathology in a model of NASH

S. Marchianò, Michele Biagioli, E. Distrutti, 2023, Scientific Reports.

Gpbar1 agonism promotes a Pgc-1α-dependent browning of white adipose tissue and energy expenditure and reverses diet-induced steatohepatitis in mice

S. Marchianò, Michele Biagioli, A. Zampella, 2017, Scientific Reports.

Transcriptome Analysis of Dual FXR and GPBAR1 Agonism in Rodent Model of NASH Reveals Modulation of Lipid Droplets Formation

S. Marchianò, Michele Biagioli, E. Distrutti, 2019, Nutrients.

Structural Basis for Developing Multitarget Compounds Acting on Cysteinyl Leukotriene Receptor 1 and G-Protein-Coupled Bile Acid Receptor 1.

S. Marchianò, V. Sepe, Michele Biagioli, 2021, Journal of medicinal chemistry.

Bile acid modulators for the treatment of nonalcoholic steatohepatitis (NASH)

V. Sepe, Michele Biagioli, E. Distrutti, 2020, Expert opinion on investigational drugs.

Glucocorticoid‐Induced Leucine Zipper (GILZ) Controls Inflammation and Tissue Damage after Spinal Cord Injury

E. Mazzon, P. Bramanti, C. Riccardi, 2014, CNS neuroscience & therapeutics.

Hijacking SARS-Cov-2/ACE2 receptor interaction by natural and semi-synthetic steroidal agents acting on functional pockets on receptor binding region

D. Francisci, Federica Moraca, S. Marchianò, 2020, bioRxiv.

Immunephenotype Predicts Response to Vedolizumab: Integrating Clinical and Biochemical Biomarkers in the Treatment of Inflammatory Bowel Diseases

Michele Biagioli, E. Distrutti, S. Fiorucci, 2018, Digestive Diseases and Sciences.

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

S. Marchianò, V. Sepe, Michele Biagioli, 2022 .

Recombinant long-glucocorticoid-induced leucine zipper (L-GILZ) protein restores the control of proliferation in gilz KO spermatogonia.

C. Riccardi, Michele Biagioli, F. Franconi, 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Expanding the Library of 1,2,4-Oxadiazole Derivatives: Discovery of New Farnesoid X Receptor (FXR) Antagonists/Pregnane X Receptor (PXR) Agonists

S. Marchianò, Michele Biagioli, C. Finamore, 2023, Molecules.

Development of bile acid activated receptors hybrid molecules for the treatment of inflammatory and metabolic disorders.

V. Sepe, Michele Biagioli, E. Distrutti, 2023, Biochemical pharmacology.

Lack of glucocorticoid-induced leucine zipper (GILZ) deregulates B-cell survival and results in B-cell lymphocytosis in mice.

E. Mazzon, C. Riccardi, Michele Biagioli, 2015, Blood.

Recombinant long-glucocorticoid-induced leucine zipper (L-GILZ) protein restores the control of proliferation in gilz KO spermatogonia.

C. Riccardi, Michele Biagioli, F. Franconi, 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Bile Acids Serve As Endogenous Antagonists Of The Leukemia Inhibitory Factor (LIF) Receptor in Oncogenesis

S. Marchianò, V. Sepe, Michele Biagioli, 2023, bioRxiv.

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

S. Marchianò, V. Sepe, Michele Biagioli, 2022, Hepatology.

Immunology of bile acids regulated receptors.

S. Marchianò, Michele Biagioli, E. Distrutti, 2024, Progress in lipid research.

Activation of GPBAR1 attenuates vascular inflammation and atherosclerosis in a mouse model of NAFLD-related cardiovascular disease.

S. Marchianò, Michele Biagioli, E. Distrutti, 2023, Biochemical pharmacology.

Development of dual GPBAR1 agonist and RORγt inverse agonist for the treatment of inflammatory bowel diseases

S. Marchianò, V. Sepe, Michele Biagioli, 2024, Pharmacological Research.

Microbial-derived bile acid reverses inflammation in IBD via GPBAR1 agonism and RORγt inverse agonism.

S. Marchianò, V. Sepe, Michele Biagioli, 2024, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.