Chao Wang

发表

Inhibition of SARS-CoV-2 infection (previously 2019-nCoV) by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion

Zhènglì Shí, W. Xu, Lu Lu, 2020, bioRxiv.

Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion

Zhènglì Shí, W. Xu, Lu Lu, 2020, Cell Research.

Triterpene sapogenin-polyarginine conjugates exhibit promising antibacterial activity against Gram-positive strains.

Keliang Liu, Chao Wang, Xiangpeng Li, 2016, Bioorganic & medicinal chemistry.

DNA Triplex-Based Complexes Display Anti-HIV-1-Cell Fusion Activity.

Tao Zhang, Liang Xu, Keliang Liu, 2015, Nucleic acid therapeutics.

Suitable fusion of N-terminal heptad repeats to achieve covalently stabilized potent N-peptide inhibitors of HIV-1 infection.

Zhuge Xi, Bencheng Lin, Chao Wang, 2019, Bioorganic & medicinal chemistry.

Design and Biological Evaluation of m-Xylene Thioether-stapled Short Helical Peptides Targeting the HIV-1 gp41 Hexameric Coiled-Coil Fusion Complex.

Wei Xu, Lu Lu, Shibo Jiang, 2019, Journal of medicinal chemistry.

Improved Pharmacological and Structural Properties of HIV Fusion Inhibitor AP3 over Enfuvirtide: Highlighting Advantages of Artificial Peptide Strategy

Q. Wang, Rongguang Zhang, Lu Lu, 2015, Scientific Reports.

25-Hydroxycholesterol-Conjugated EK1 Peptide with Potent and Broad-Spectrum Inhibitory Activity against SARS-CoV-2, Its Variants of Concern, and Other Human Coronaviruses

Jie Zhou, Lu Lu, Shibo Jiang, 2021, International journal of molecular sciences.

Site-specific Isopeptide Bridge Tethering of Chimeric gp41 N-terminal Heptad Repeat Helical Trimers for the Treatment of HIV-1 Infection

Lu Lu, Shibo Jiang, L. Ye, 2016, Scientific reports.

An effective conjugation strategy for designing short peptide-based HIV-1 fusion inhibitors.

Keliang Liu, Chao Wang, Yuxian He, 2016, Organic & biomolecular chemistry.

De novo design of isopeptide bond-tethered triple-stranded coiled coils with exceptional resistance to unfolding and proteolysis: implication for developing antiviral therapeutics† †Electronic supplementary information (ESI) available: General materials, methods and the details. See DOI: 10.1039/c5s

Lu Lu, Shibo Jiang, Keliang Liu, 2015, Chemical science.

Artificial peptides conjugated with cholesterol and pocket-specific small molecules potently inhibit infection by laboratory-adapted and primary HIV-1 isolates and enfuvirtide-resistant HIV-1 strains.

Liang Xu, Lu Lu, Shibo Jiang, 2014, The Journal of antimicrobial chemotherapy.

A "Two-Birds-One-Stone" Approach toward the Design of Bifunctional Human Immunodeficiency Virus Type 1 Entry Inhibitors Targeting the CCR5 Coreceptor and gp41 N-Terminal Heptad Repeat Region.

Lu Lu, Shibo Jiang, Chao Wang, 2021, Journal of medicinal chemistry.

Design of highly potent HIV fusion inhibitors based on artificial peptide sequences.

Liang Xu, Lu Lu, Shibo Jiang, 2012, Chemical communications.

Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion

Lu Lu, Shibo Jiang, Siliang Feng, 2020, Cell Research.

A highly potent and stable pan-coronavirus fusion inhibitor as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases

Jie Zhou, Lu Lu, Shibo Jiang, 2021, Acta Pharmaceutica Sinica B.

Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion

W. Xu, Lu Lu, Shibo Jiang, 2020, Cell Research.

Peptide-based pan-CoV fusion inhibitors maintain high potency against SARS-CoV-2 Omicron variant

J. Chan, K. Yuen, Lu Lu, 2022, Cell Research.

Precisely Designed Isopeptide Bridge-Crosslinking Endows Artificial Hydrolases with High Stability and Catalytic Activity under Extreme Denaturing Conditions.

Keliang Liu, Chao Wang, M. Cheng, 2017, Chemistry, an Asian journal.

Structural and functional basis for pan-CoV fusion inhibitors against SARS-CoV-2 and its variants with preclinical evaluation

F. Kirchhoff, Jie Zhou, J. Münch, 2021, Signal Transduction and Targeted Therapy.

Conjugation of a nonspecific antiviral sapogenin with a specific HIV fusion inhibitor: a promising strategy for discovering new antiviral therapeutics.

Lu Lu, Shibo Jiang, Qian Wang, 2014, Journal of medicinal chemistry.

Multitargeted drug design strategy for discovery of short-peptide-based HIV-1 entry inhibitors with high potency.

Lu Lu, Chao Wang, F. Yu, 2023, European journal of medicinal chemistry.

Discovery of Hydrocarbon-Stapled Short α-Helical Peptides as Promising Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Fusion Inhibitors

Shibo Jiang, Keliang Liu, S. Xia, 2018, Journal of medicinal chemistry.

Design, synthesis, and biological evaluation of highly potent small molecule-peptide conjugates as new HIV-1 fusion inhibitors.

Liang Xu, Jinglai Li, Lu Lu, 2013, Journal of medicinal chemistry.

De Novo Design of α-Helical Lipopeptides Targeting Viral Fusion Proteins: A Promising Strategy for Relatively Broad-Spectrum Antiviral Drug Discovery

Shibo Jiang, Keliang Liu, S. Xia, 2018, Journal of medicinal chemistry.

Supercoiling Structure-Based Design of a Trimeric Coiled-Coil Peptide with High Potency against HIV-1 and Human β-Coronavirus Infection

S. Huo, Lu Lu, Shibo Jiang, 2021, Journal of medicinal chemistry.

An Artificial Peptide-Based Bifunctional HIV-1 Entry Inhibitor That Interferes with Viral Glycoprotein-41 Six-Helix Bundle Formation and Antagonizes CCR5 on the Host Cell Membrane

Y. Liu, Lu Lu, Chao Wang, 2023, Viruses.

An effective strategy for recapitulating N-terminal heptad repeat trimers in enveloped virus surface glycoproteins for therapeutic applications† †Electronic supplementary information (ESI) available: General materials, methods, and the details. See DOI: 10.1039/c5sc04046a

Lu Lu, Shibo Jiang, Keliang Liu, 2015, Chemical science.

A dePEGylated Lipopeptide-Based Pan-Coronavirus Fusion Inhibitor Exhibits Potent and Broad-Spectrum Anti-HIV-1 Activity without Eliciting Anti-PEG Antibodies

Jie Zhou, Lu Lu, Chao Wang, 2023, International journal of molecular sciences.