J. Harrison

发表

Role of electrostatic repulsion in controlling pH-dependent conformational changes of viral fusion proteins.

Matthew J. O’Meara, B. Kuhlman, J. Lai, 2013, Structure.

p62-Dependent Phase Separation of Patient-Derived KEAP1 Mutations and NRF2

N. Dokholyan, D. Goldfarb, M. B. Major, 2018, Molecular and Cellular Biology.

Contribution of light chain residues to high affinity binding in an HIV-1 antibody explored by combinatorial scanning mutagenesis.

J. Lai, J. Harrison, G. D. Da Silva, 2010, Biochemistry.

Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler

M. Mann, Gerbrand J. van der Heden van Noort, H. Ovaa, 2020, Nature Chemical Biology.

Mechanism of Lysine 48 Selectivity during Polyubiquitin Chain Formation by the Ube2R1/2 Ubiquitin-Conjugating Enzyme

Steven M. Lewis, B. Kuhlman, G. Kleiger, 2016, Molecular and Cellular Biology.

KRAS Ubiquitination at Lysine 104 Retains Exchange Factor Regulation by Dynamically Modulating the Conformation of the Interface

A. Gorfe, J. Harrison, S. Campbell, 2020, iScience.

Hemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1

B. Kuhlman, B. Strahl, C. Arrowsmith, 2016, eLife.

Caught in the act The crystal structure of a HECT E3 enzyme has been captured as it transfers ubiquitin to a target protein, revealing the dramatic changes in shape that enable it to modify particular residues in its targets.

Steven M. Lewis, M. Rapé, A. Deng, 2013 .

A Bifunctional Role for the UHRF1 UBL Domain in the Control of Hemi-methylated DNA-Dependent Histone Ubiquitylation.

B. Kuhlman, T. Davis, P. Brzovic, 2018, Molecular cell.

Side chain requirements for affinity and specificity in D5, an HIV-1 antibody derived from the VH1-69 germline segment

J. Lai, J. Harrison, A. Stewart, 2013, BMC Biochemistry.

8-20-2018 p 62-dependent phase separation of patient-derived KEAP 1 mutations and NRF 2

N. Dokholyan, D. Goldfarb, J. Harrison, 2018 .

Crystal structure of the Marburg virus GP2 core domain in its postfusion conformation.

V. Malashkevich, S. Almo, K. Chandran, 2012, Biochemistry.

Marburg virus glycoprotein GP2: pH-dependent stability of the ectodomain α-helical bundle.

K. Chandran, J. Lai, J. Harrison, 2012, Biochemistry.

Coevolutionary Analysis Implicates Toll-Like Receptor 9 in Papillomavirus Restriction

M. Worobey, J. Harrison, A. Varsani, 2022, mBio.

Co-evolutionary analysis suggests a role for TLR9 in papillomavirus restriction

M. Worobey, J. Harrison, A. Varsani, 2021, bioRxiv.

Comparative biochemical analysis of UHRF proteins reveals molecular mechanisms that uncouple UHRF2 from DNA methylation maintenance

B. Kuhlman, B. Dickson, J. Harrison, 2018, Nucleic acids research.

Identification and Characterization of MCM3 as a Kelch-like ECH-associated Protein 1 (KEAP1) Substrate*

J. Cook, D. Goldfarb, C. Vaziri, 2016, The Journal of Biological Chemistry.

Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via the Thalidomide Receptor Cereblon.

Justin M. Reitsma, Michael J. Sweredoski, B. Kuhlman, 2016, Molecular cell.

Enhancement of cell proliferation and motility of mammalian cells grown in co-culture with Pichia pastoris expressing recombinant human FGF-2.

Der Thor, Nan Xiao, J. Harrison, 2020, Protein expression and purification.

Inhibition of Ebola Virus Entry by a C-peptide Targeted to Endosomes

K. Chandran, J. Kuhn, S. Radoshitzky, 2011, The Journal of Biological Chemistry.

In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators

Michael J. Emanuele, Jeffrey S. Damrauer, Rochelle L. Tiedemann, 2020, PLoS biology.

In silico APC/C substrate discovery reveals cell cycle degradation of chromatin regulators including UHRF1

Michael J. Emanuele, Jeffrey S. Damrauer, Rochelle L. Tiedemann, 2020, bioRxiv.

An Allosteric Interaction Links USP7 to Deubiquitination and Chromatin Targeting of UHRF1.

B. Strahl, G. Wang, Jikui Song, 2015, Cell reports.

Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C

B. Kuhlman, M. Kirschner, J. Peters, 2016, Cell.

Dual RING E 3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC / C Graphical

B. Kuhlman, M. Kirschner, J. Peters, 2022 .

Mechanically transduced immunosorbent assay to measure protein-protein interactions

B. Strahl, J. Steimel, J. Harrison, 2021, bioRxiv.

Functional conservation and divergence of the helix‐turn‐helix motif of E2 ubiquitin‐conjugating enzymes

Michael J. Emanuele, A. Ordureau, J. Boyer, 2021, The EMBO journal.

Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3

Steven M. Lewis, B. Kuhlman, B. Schulman, 2013, eLife.

Identification of disease-linked hyperactivating mutations in UBE3A through large-scale functional variant analysis

M. Shinawi, Kwang-Soo Kim, S. Parikh, 2021, Nature Communications.

From Protein Design to the Energy Landscape of a Cold Unfolding Protein

Jack B. Maguire, Jermel R. Griffin, Surya V. S. R. K. Pulavarti, 2022, The journal of physical chemistry. B.

Insight into Viral Hijacking of CRL4 Ubiquitin Ligase through Structural Analysis of the pUL145-DDB1 Complex

Y. Xiong, N. Nicely, A. Baldwin, 2022, Journal of virology.

Designed protein mimics of the Ebola virus glycoprotein GP2 α-helical bundle: Stability and pH effects

K. Chandran, J. Lai, J. Harrison, 2011, Protein science : a publication of the Protein Society.

Inside-Out Design of Zinc-Binding Proteins with Non-Native Backbones.

Surya V. S. R. K. Pulavarti, B. Kuhlman, T. Szyperski, 2023, Biochemistry.

Mechanism of Lysine 48 Selectivity during Polyubiquitin Chain Formation by the Ube2R1/2 Ubiquitin-Conjugating Enzyme

Steven M. Lewis, B. Kuhlman, J. Harrison, 2016, Molecular and Cellular Biology.

Data in support of UbSRD: The Ubiquitin Structural Relational Database

Brian Kuhlman, Kevin Houlihan, Koenraad Van Doorslaer, 2015, Data in brief.

A Bifunctional Role for the UHRF1 UBL Domain in the Control of Hemi-methylated DNA-Dependent Histone Ubiquitylation.

B. Kuhlman, T. Davis, P. Brzovic, 2018, Molecular cell.

Protein semisynthesis underscores role of a conserved lysine in activation and desensitization of acid-sensing ion channels

Gerbrand J. van der Heden van Noort, S. Heusser, J. Harrison, 2023, bioRxiv.

UbSRD: The Ubiquitin Structural Relational Database.

Brian Kuhlman, Joseph S Harrison, Tim M Jacobs, 2016, Journal of molecular biology.

The effect of the bgs13 mutation on the structure of the reporter protein beta-lactoglobulin: Influence on folding and aggregation in Pichia pastoris.

J. Harrison, A. Franz, Geoff P. Lin-Cereghino, 2023, Protein expression and purification.