S. Wharton

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Conformational changes in the hemagglutinin of influenza virus which accompany heat-induced fusion of virus with liposomes.

J. Skehel, D. Wiley, S. Martin, 1986, Virology.

The receptor‐binding and membrane‐fusion properties of influenza virus variants selected using anti‐haemagglutinin monoclonal antibodies.

J. Skehel, D. Wiley, J. Paulson, 1987, The EMBO journal.

Studies on the structure of the influenza virus haemagglutinin at the pH of membrane fusion.

J. Skehel, D. Wiley, W. Weis, 1988, The Journal of general virology.

A soluble domain of the membrane-anchoring chain of influenza virus hemagglutinin (HA2) folds in Escherichia coli into the low-pH-induced conformation.

W. Weissenhorn, J. Skehel, D. Wiley, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Functional reconstitution in lipid vesicles of influenza virus M2 protein expressed by baculovirus: evidence for proton transfer activity.

C. Ford, S. Wharton, C. Schroeder, 1994, The Journal of general virology.

Amantadine selection of a mutant influenza virus containing an acid-stable hemagglutinin glycoprotein: evidence for virus-specific regulation of the pH of glycoprotein transport vesicles.

J. Skehel, D. Wiley, D. Steinhauer, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Electron microscopy of antibody complexes of influenza virus haemagglutinin in the fusion pH conformation.

J. Skehel, D. Wiley, R. Ruigrok, 1995, The EMBO journal.

Characterization of neutralizing epitopes in antigenic site B of recently circulating influenza A(H3N2) viruses

S. Howell, S. Wharton, R. Daniels, 2018, The Journal of general virology.

Glyconanoparticles for the plasmonic detection and discrimination between human and avian influenza virus.

D. A. Russell, D. Russell, M. Rejžek, 2013, Organic & biomolecular chemistry.

Evolution of the receptor binding properties of the influenza A(H3N2) hemagglutinin

Alan J. Hay, Xiaoli Xiong, Steven J. Gamblin, 2012, Proceedings of the National Academy of Sciences.

Neuraminidase Receptor Binding Variants of Human Influenza A(H3N2) Viruses Resulting from Substitution of Aspartic Acid 151 in the Catalytic Site: a Role in Virus Attachment?

P. Collins, S. Wharton, A. Hay, 2010, Journal of Virology.

Viruses due to Substitution of Aspartic acid 151 in the Catalytic Site – Role in Virus Attachment ?

P. Collins, S. Wharton, A. Hay, 2010 .

Plasticity of influenza haemagglutinin fusion peptides and their interaction with lipid bilayers.

Franca Fraternali, Jens Kleinjung, J. Skehel, 2005, Biophysical journal.

Thermostability of the human respiratory syncytial virus fusion protein before and after activation: implications for the membrane-fusion mechanism.

J. Skehel, D. Martin, B. García-Barreno, 2004, The Journal of general virology.

A monoclonal antibody specific to the HA2 glycoprotein of influenza A virus hemagglutinin that inhibits its fusion activity reduces replication of the virus.

S. Wharton, F. Kostolanský, E. Varečková, 2003, Acta virologica.

Inhibition of fusion activity of influenza A haemagglutinin mediated by HA2-specific monoclonal antibodies

S. Wharton, F. Kostolanský, E. Varečková, 2003, Archives of Virology.

An antibody that prevents the hemagglutinin low pH fusogenic transition.

J. Skehel, S. Wharton, L. Calder, 2002, Virology.

Structure of influenza virus haemagglutinin complexed with a neutralizing antibody

Pascal Rigolet, Olivier Diat, J. Skehel, 1995, Nature.

Antigen distortion allows influenza virus to escape neutralization

Damien Fleury, J. Skehel, S. Wharton, 1998, Nature Structural Biology.

Studies of the binding properties of influenza hemagglutinin receptor-site mutants.

J. Skehel, D. Wiley, D. Steinhauer, 1998, Virology.

Interaction of influenza virus hemagglutinin with a lipid monolayer. A comparison of the surface activities of intact virions, isolated hemagglutinins, and a synthetic fusion peptide.

A. Verkleij, S. Wharton, K. Burger, 1991, Biochemistry.

Role of Neuraminidase in Influenza A(H7N9) Virus Receptor Binding

Stephen R. Martin, D. Benton, S. Wharton, 2017, Journal of Virology.

Structure, Function, and Antigenicity of the Hemagglutinin of Influenza Virus

Don C. Wiley, J. Skehel, D. Wiley, 1989 .

Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma

L. Staudt, W. Chan, G. Lenz, 2009, Proceedings of the National Academy of Sciences.

Membrane fusion by influenza hemagglutinin.

J. Skehel, D. Wiley, P. Bullough, 1995, Cold Spring Harbor symposia on quantitative biology.

Electron microscopy of the human respiratory syncytial virus fusion protein and complexes that it forms with monoclonal antibodies.

J. Skehel, D. Wiley, L. González-Reyes, 2000, Virology.

Membrane fusion by peptide analogues of influenza virus haemagglutinin.

J. Skehel, D. Wiley, S. Martin, 1988, The Journal of general virology.

Effect of sterol structure on the transfer of sterols and phospholipids from liposomes to erythrocytes in vitro.

S. Wharton, C. Green, Stephen A. Wharton, 1982, Biochimica et biophysica acta.

Electron microscopy of the influenza virus submembranal structure.

R. Ruigrok, S. Wharton, L. Calder, 1989, Virology.

Role of virion M2 protein in influenza virus uncoating: specific reduction in the rate of membrane fusion between virus and liposomes by amantadine.

J. Skehel, R. Belshe, S. Wharton, 1994, The Journal of general virology.

The strong positive correlation between effective affinity and infectivity neutralization of highly cross-reactive monoclonal antibody IIB4, which recognizes antigenic site B on influenza A virus haemagglutinin.

S. Wharton, F. Kostolanský, E. Varečková, 2000, The Journal of general virology.

Optimisation of a micro-neutralisation assay and its application in antigenic characterisation of influenza viruses

S. Wharton, A. Hay, R. Daniels, 2015, Influenza and other respiratory viruses.

Changes in the hemagglutinin of H5N1 viruses during human infection – Influence on receptor binding☆

J. Farrar, J. Skehel, S. Gamblin, 2013, Virology.

Degradation of peptides and proteins of different sizes by homogenates of human MRC5 lung fibroblasts

A. Hipkiss, S. Wharton, A.R. Hipkiss, 1985, FEBS letters.

Abnormal proteins of shortened length are preferentially degraded in the cytosol of cultured MRC5 fibroblasts

S. Wharton, A. R. Hipkiss, 1984, FEBS letters.

Influenza H2 haemagglutinin activates B cells via a MyD88‐dependent pathway

P. Borrow, S. Wharton, David Wiseman, 2006, European journal of immunology.

Receptor-binding specificity of pandemic influenza A (H1N1) 2009 virus determined by carbohydrate microarray

Ten Feizi, Yan Liu, Markus Eickmann, 2009, Nature Biotechnology.

Corrigendum: Receptor-binding specificity of pandemic influenza A (H1N1) 2009 virus determined by carbohydrate microarray

M. Kiso, M. Eickmann, S. Wharton, 2010, Nature Biotechnology.

Intravaginal immunization in sheep using a bioadhesive microsphere antigen delivery system.

S. Wharton, L. Illum, D. Rafferty, 1993, Vaccine.

Deacylation of the hemagglutinin of influenza A/Aichi/2/68 has no effect on membrane fusion properties.

J. Skehel, D. Wiley, D. Steinhauer, 1991, Virology.

The interaction of synthetic analogs of the N-terminal fusion sequence of influenza virus with a lipid monolayer. Comparison of fusion-active and fusion-defective analogs.

A. Verkleij, S. Wharton, K. Burger, 1991, Biochimica et biophysica acta.

1 – Membrane Fusion by Influenza Viruses and the Mechanism of Action of Amantadine

J. Skehel, S. Wharton, A. Hay, 1990 .

The characteristics and antigenic properties of recently emerged subclade 3C.3a and 3C.2a human influenza A(H3N2) viruses passaged in MDCK cells

S. Wharton, R. Daniels, B. Ermetal, 2017, Influenza and other respiratory viruses.

Interaction of mutant influenza virus hemagglutinin fusion peptides with lipid bilayers: probing the role of hydrophobic residue size in the central region of the fusion peptide.

D. Steinhauer, S. Wharton, L. Tamm, 1999, Biochemistry.

Amantadine Variants Activity Against Multiple Influenza A Viruses

Chunlong Ma, Jun Wang, S. Wharton, 2021 .

The suppression of endogenous protein degradation by fractions of foetal calf serum: Dialysed serum is less able to suppress degradation in aged cells

S. Wharton, P. Riley, 1986, Cell biochemistry and function.

Design of inhibitors of influenza virus membrane fusion: synthesis, structure-activity relationship and in vitro antiviral activity of a novel indole series.

M. de Rosa, G. Donnarumma, V. Brancato, 2013, Antiviral research.

Studies of the membrane fusion activities of fusion peptide mutants of influenza virus hemagglutinin

J. Skehel, D. Wiley, D. Steinhauer, 1995, Journal of virology.

Temperature dependence of fusion by sendai virus.

J. Skehel, D. Wiley, S. Wharton, 2000, Virology.

Receptor binding by an H7N9 influenza virus from humans

P. Collins, J. Skehel, X. Xiong, 2013, Nature.

The role of influenza virus haemagglutinin in membrane fusion.

S. Wharton, 1987, Microbiological sciences.

The ectodomain of HIV‐1 env subunit gp41 forms a soluble, alpha‐helical, rod‐like oligomer in the absence of gp120 and the N‐terminal fusion peptide.

P. Earl, B. Moss, W. Weissenhorn, 1996, The EMBO journal.

Studies using double mutants of the conformational transitions in influenza hemagglutinin required for its membrane fusion activity.

J. Skehel, D. Wiley, D. Steinhauer, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Fusion characteristics of influenza C viruses.

S. Wharton, L. Calder, H. Meier-Ewert, 1990, The Journal of general virology.

The central structural feature of the membrane fusion protein subunit from the Ebola virus glycoprotein is a long triple-stranded coiled coil.

W. Weissenhorn, J. Skehel, D. Wiley, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Introduction of intersubunit disulfide bonds in the membrane-distal region of the influenza hemagglutinin abolishes membrane fusion activity

J. Skehel, D. Wiley, B. Ely, 1992, Cell.

Altered Receptor Specificity and Cell Tropism of D222G Hemagglutinin Mutants Isolated from Fatal Cases of Pandemic A(H1N1) 2009 Influenza Virus

Yan Liu, Ten Feizi, H. Klenk, 2010, Journal of Virology.

Effects of egg-adaptation on receptor-binding and antigenic properties of recent influenza A (H3N2) vaccine viruses

S. Wharton, R. Daniels, J. McCauley, 2016, The Journal of general virology.

Reduced sialidase activity of influenza A(H3N2) neuraminidase associated with positively charged amino acid substitutions.

Steven A. Howell, S. Wharton, R. Daniels, 2021, The Journal of general virology.

An antibody which binds to the membrane-proximal end of influenza virus haemagglutinin (H3 subtype) inhibits the low-pH-induced conformational change and cell-cell fusion but does not neutralize virus.

W. Fiers, S. Wharton, L. Calder, 1998, The Journal of general virology.

Biophysical Measurement of the Balance of Influenza A Hemagglutinin and Neuraminidase Activities*

D. Benton, S. Wharton, J. McCauley, 2015, The Journal of Biological Chemistry.

Studies of influenza haemagglutinin-mediated membrane fusion.

J. Skehel, D. Wiley, S. Wharton, 1986, Virology.

Adaptation of egg-grown and transfectant influenza viruses for growth in mammalian cells: selection of hemagglutinin mutants with elevated pH of membrane fusion.

J. Skehel, D. Wiley, D. Steinhauer, 1997, Virology.

Electron microscopy of the low pH structure of influenza virus haemagglutinin.

J. Skehel, S. Cusack, R. Ruigrok, 1986, The EMBO journal.

Correction for Basner et al., Mars 520-d mission simulation reveals protracted crew hypokinesis and alterations of sleep duration and timing

J. Skehel, X. Xiong, S. Gamblin, 2013, Proceedings of the National Academy of Sciences.

Studies on influenza haemagglutinin fusion peptide mutants generated by reverse genetics

J. Skehel, D. Wiley, D. Steinhauer, 2001, The EMBO journal.

Effect of the N-terminal glycine on the secondary structure, orientation, and interaction of the influenza hemagglutinin fusion peptide with lipid bilayers.

C. Gray, S. Tatulian, S. Wharton, 1996, Biophysical journal.

Conformational aspects of the acid-induced fusion mechanism of influenza virus hemagglutinin. Circular dichroism and fluorescence studies.

J. Skehel, D. Wiley, W. Weis, 1988, The Journal of biological chemistry.

Structural changes in influenza virus haemagglutinin at the pH of membrane fusion.

J. Skehel, R. Ruigrok, S. Wharton, 1986, Biochemical Society Transactions.

Use of fluorescent probes in the study of phospholipid--sterol bilayers.

S. Wharton, C. Green, S. G. De Martínez, 1980, Biochemical Journal.

The effect of agents influencing cytoskeletal elements upon the dielectrophoretic behavior of cultured epidermal cells

S. Wharton, P. Riley, 1981 .