C. Chaudhry

发表

Influenza hemagglutinin is spring-loaded by a metastable native conformation.

P S Kim, P. S. Kim, C. Carr, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Energetics of glutamate receptor ligand binding domain dimer assembly are modulated by allosteric ions

M. Mayer, C. Chaudhry, P. Schuck, 2009, Proceedings of the National Academy of Sciences.

Stability of ligand‐binding domain dimer assembly controls kainate receptor desensitization

Peter Schuck, Charu Chaudhry, Christian Rosenmund, 2009, The EMBO journal.

Building homogeneous time-resolved fluorescence resonance energy transfer assays for characterization of bivalent inhibitors of an inhibitor of apoptosis protein target.

Shana L. Posy, W. Metzler, R. Talbott, 2016, Analytical biochemistry.

Enhanced antitumor immunity by a novel small molecule HPK1 inhibitor

E. Lees, R. Bhadra, J. Hunt, 2021, Journal for ImmunoTherapy of Cancer.

Autoimmune pathways in mice and humans are blocked by pharmacological stabilization of the TYK2 pseudokinase domain

K. McIntyre, C. Chaudhry, L. Salter-Cid, 2019, Science Translational Medicine.

Accounting for solvent signal offsets in the analysis of interferometric sedimentation velocity data.

M. Mayer, R. Ghirlando, P. Brown, 2010, Macromolecular bioscience.

Mathematical Model for Covalent Proteolysis Targeting Chimeras: Thermodynamics and Kinetics Underlying Catalytic Efficiency.

C. Chaudhry, 2023, Journal of medicinal chemistry.

Direct-to-Biology Accelerates PROTAC Synthesis and the Evaluation of Linker Effects on Permeability and Degradation

Iulia I. Strambeanu, Jennifer D. Venable, C. Chaudhry, 2022, ACS medicinal chemistry letters.

Discovery of highly potent, selective, covalent inhibitors of JAK3.

S. Spergel, G. Schieven, J. Barrish, 2017, Bioorganic & medicinal chemistry letters.

Discovery of tetrahydroisoquinoline-based bivalent heterodimeric IAP antagonists.

Shana L. Posy, R. Talbott, S. Emanuel, 2014, Bioorganic & medicinal chemistry letters.

Identification of N-Methyl Nicotinamide and N-Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2).

S. Spergel, K. McIntyre, J. Tokarski, 2019, Journal of medicinal chemistry.

349 - BMS-986165 is a Highly Potent and Selective Allosteric Inhibitor of TYK2, Blocks Il-12, IL-23 and type I Interferon Signaling and Provides for Robust Efficacy in Preclinical Models of Inflammatory Bowel Disease

J. Chen, C. Chaudhry, K. Gillooly, 2018 .

Pharmacology of smac mimetics; chemotype differentiation based on physical association with caspase regulators and cellular transport.

J. Fargnoli, R. Talbott, J. Hunt, 2015, Experimental cell research.

Dimeric Macrocyclic Antagonists of Inhibitor of Apoptosis Proteins for the Treatment of Cancer.

Shana L. Posy, J. Fargnoli, R. Talbott, 2015, ACS medicinal chemistry letters.

Discovery of potent heterodimeric antagonists of inhibitor of apoptosis proteins (IAPs) with sustained antitumor activity.

J. Fargnoli, R. Talbott, S. Emanuel, 2015, Journal of medicinal chemistry.

Ultrasensitive quantitative LC-MS/MS of an inhibitor of apoptosis protein's antagonist in plasma using protein target affinity extraction.

R. Talbott, R. Borzilleri, T. Olah, 2016, Bioanalysis.

A High-Throughput BRET Cellular Target Engagement Assay Links Biochemical to Cellular Activity for Bruton’s Tyrosine Kinase

B. Arey, C. Chaudhry, A. Tebben, 2019, SLAS discovery : advancing life sciences R & D.

Identification of imidazo[1,2-b]pyridazine TYK2 pseudokinase ligands as potent and selective allosteric inhibitors of TYK2 signalling.

J. Tokarski, D. Xie, N. Araníbar, 2017, MedChemComm.

Discovery of Non-Nucleotide Small-Molecule STING Agonists via Chemotype Hybridization.

Alan S. Futran, Vijay T. Ahuja, Shana L. Posy, 2022, Journal of medicinal chemistry.

Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165.

S. Spergel, K. McIntyre, D. Shuster, 2019, Journal of medicinal chemistry.

Identification of Imidazo[1,2-b]pyridazine Derivatives as Potent, Selective, and Orally Active Tyk2 JH2 Inhibitors.

James Lin, K. McIntyre, J. Tokarski, 2019, ACS medicinal chemistry letters.

An innovative kinome platform to accelerate small-molecule inhibitor discovery and optimization from hits to leads.

J. Tokarski, R. Borzilleri, W. Pitts, 2021, Drug discovery today.

Quantifying Target Occupancy of Small Molecules Within Living Cells.

M B Robers, R Friedman-Ohana, K Huber, 2020, Annual review of biochemistry.

Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton's Tyrosine Kinase (BTK).

Michael A. Galella, K. McIntyre, J. Macor, 2019, Journal of medicinal chemistry.

Role of the γ‐phosphate of ATP in triggering protein folding by GroEL–GroES: function, structure and energetics

Charu Chaudhry, P. Adams, G. Farr, 2003, The EMBO journal.

Role of the g-phosphate of ATP in triggering protein folding by GroEL-GroES: function, structure and

A. Horwich, C. Chaudhry, 2003 .

Substrate polypeptide presents a load on the apical domains of the chaperonin GroEL.

G. Farr, A. Horwich, W. Fenton, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Exploring the structural dynamics of the E.coli chaperonin GroEL using translation-libration-screw crystallographic refinement of intermediate states.

Axel T Brunger, Paul D Adams, Charu Chaudhry, 2004, Journal of molecular biology.

Evaluation of Grouting as a Strengthening Technique for Earthen Structures in Seismic Areas: Case Study Chiripa

Charu Chaudhry, C. Chaudhry, 2007 .

Conversion of carbazole carboxamide based reversible inhibitors of Bruton's tyrosine kinase (BTK) into potent, selective irreversible inhibitors in the carbazole, tetrahydrocarbazole, and a new 2,3-dimethylindole series.

C. Chaudhry, P. Carter, Neha Surti, 2018, Bioorganic & medicinal chemistry letters.

Discovery of BMS-986202: A Clinical Tyk2 Inhibitor that Binds to Tyk2 JH2.

James Lin, K. McIntyre, D. Shuster, 2020, Journal of medicinal chemistry.

Identification of RIPK3 Type II Inhibitors Using High-Throughput Mechanistic Studies in Hit Triage.

J. Macor, C. Weigelt, K. Kish, 2019, ACS medicinal chemistry letters.

Building and Breaking Interfaces: How a Receptor Takes Shape

A. Scimemi, C. Chaudhry, J. Kumar, 2011, Journal of Neuroscience.

Identification of RIPK3 Type II Inhibitors Using High-Throughput Mechanistic Studies in Hit Triage.

J. Macor, C. Weigelt, K. Kish, 2019, ACS medicinal chemistry letters.