S. Leikin

发表

Reversible electrical breakdown of lipid bilayers: formation and evolution of pores.

L. Chernomordik, V. Pastushenko, R. Glaser, 1988, Biochimica et biophysica acta.

Structure and interactions of biological helices

A. Kornyshev, S. Leikin, Dominic J. Lee, 2007 .

Type I collagen is thermally unstable at body temperature

E. Leikina, S. Leikin, M. Mertts, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Raman spectral evidence for hydration forces between collagen triple helices.

V A Parsegian, V. Parsegian, S. Leikin, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Hydration forces.

V. Parsegian, S. Leikin, D. Rau, 1993, Annual review of physical chemistry.

Solvent hydrogen-bond network in protein self-assembly: solvation of collagen triple helices in nonaqueous solvents.

V. Parsegian, S. Leikin, D. Rau, 1997, Biophysical journal.

Does the Triple Helical Domain of Type I Collagen Encode Molecular Recognition and Fiber Assembly while Telopeptides Serve as Catalytic Domains?

S. Leikin, N. Kuznetsova, 1999, The Journal of Biological Chemistry.

Electrostatic interaction between helical macromolecules in dense aggregates: an impetus for DNA poly- and meso-morphism.

A. Kornyshev, S. Leikin, Sergey Leikin, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Electrostatic Zipper Motif for DNA Aggregation

A. Kornyshev, S. Leikin, 1999 .

Mutations in WNT1 cause different forms of bone fragility.

S. Mundlos, K. Garcia, P. Krawitz, 2013, American journal of human genetics.

In utero transplantation of adult bone marrow decreases perinatal lethality and rescues the bone phenotype in the knockin murine model for classical, dominant osteogenesis imperfecta.

S. Goldstein, J. Vera, E. Perilli, 2009, Blood.

Genetic Defects in TAPT1 Disrupt Ciliogenesis and Cause a Complex Lethal Osteochondrodysplasia.

A. De Paepe, S. Leikin, G. Gillessen‐kaesbach, 2015, American journal of human genetics.

Osteoblast Malfunction Caused by Cell Stress Response to Procollagen Misfolding in α2(I)‐G610C Mouse Model of Osteogenesis Imperfecta

S. Leikin, S. Omari, E. L. Mertz, 2016, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

COL1 C‐propeptide cleavage site mutations cause high bone mass osteogenesis imperfecta

T. Hefferan, M. Yaszemski, A. Boskey, 2011, Human mutation.

Selective retention and degradation of molecules with a single mutant alpha1(I) chain in the Brtl IV mouse model of OI.

S. Leikin, A. Forlino, J. Marini, 2007, Matrix biology : journal of the International Society for Matrix Biology.

Prolyl 3-hydroxylase 1 deficiency causes a recessive metabolic bone disorder resembling lethal/severe osteogenesis imperfecta

C. Tifft, Peter A. Smith, D. Eyre, 2007, Nature Genetics.

Makings of a brittle bone: Unexpected lessons from a low protein diet study of a mouse OI model.

K. Kozloff, S. Leikin, E. L. Mertz, 2016, Matrix biology : journal of the International Society for Matrix Biology.

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

Mark R. Marten, Erinna F. Lee, Dana L. Miller, 2021, Autophagy.

Lack of cyclophilin B in osteogenesis imperfecta with normal collagen folding.

C. Rotimi, D. Eyre, Wei-zhong Chang, 2010, The New England journal of medicine.

Deficiency of cartilage-associated protein in recessive lethal osteogenesis imperfecta.

J. Mulvihill, Brendan H. Lee, D. Eyre, 2006, The New England journal of medicine.

Substitution of murine type I collagen A1 3-hydroxylation site alters matrix structure but does not recapitulate osteogenesis imperfecta bone dysplasia.

P. Backlund, D. Eyre, K. Kozloff, 2020, Matrix biology : journal of the International Society for Matrix Biology.

Celecoxib treatment of fibrous dysplasia (FD) in a human FD cell line and FD-like lesions in mice with protein kinase A (PKA) defects

C. Stratakis, N. Bhattacharyya, S. Leikin, 2017, Molecular and Cellular Endocrinology.

Y‐position cysteine substitution in type I collagen (α1(I) R888C/p.R1066C) is associated with osteogenesis imperfecta/Ehlers‐Danlos syndrome phenotype

A. Fertala, D. Keene, S. Leikin, 2007, Human mutation.

Mutations Near Amino End of α1(I) Collagen Cause Combined Osteogenesis Imperfecta/Ehlers-Danlos Syndrome by Interference with N-propeptide Processing*

G. Pals, A. Colige, S. Leikin, 2005, Journal of Biological Chemistry.

Type I Collagen Triplet Duplication Mutation in Lethal Osteogenesis Imperfecta Shifts Register of α Chains throughout the Helix and Disrupts Incorporation of Mutant Helices into Fibrils and Extracellular Matrix*

M. Tekin, A. Pandya, A. Colige, 2003, The Journal of Biological Chemistry.

Absence of the ER Cation Channel TMEM38B/TRIC-B Disrupts Intracellular Calcium Homeostasis and Dysregulates Collagen Synthesis in Recessive Osteogenesis Imperfecta

L. Ala‐Kokko, P. Blank, J. Zimmerberg, 2016, PLoS genetics.

Absence of FKBP10 in recessive type XI osteogenesis imperfecta leads to diminished collagen cross‐linking and reduced collagen deposition in extracellular matrix

D. Eyre, S. Leikin, E. L. Mertz, 2012, Human mutation.

Deficiency of CRTAP in non‐lethal recessive osteogenesis imperfecta reduces collagen deposition into matrix

D. Eyre, S. Leikin, S. Viglio, 2012, Clinical genetics.

Deficient degradation of homotrimeric type I collagen, α1(I)3 glomerulopathy in oim mice.

Andrew L. Walker, S. Leikin, C. Besch-Williford, 2011, Molecular genetics and metabolism.

Zebrafish Collagen Type I: Molecular and Biochemical Characterization of the Major Structural Protein in Bone and Skin

B. Menten, K. Gevaert, A. De Paepe, 2016, Scientific Reports.

Measured effects of diacylglycerol on structural and elastic properties of phospholipid membranes.

M. Kozlov, S. Leikin, R. Rand, 1996, Biophysical journal.

Bending, hydration and interstitial energies quantitatively account for the hexagonal-lamellar-hexagonal reentrant phase transition in dioleoylphosphatidylethanolamine.

M. Kozlov, S. Leikin, R. Rand, 1994, Biophysical journal.

Haploinsufficiency for either one of the type-II regulatory subunits of protein kinase A improves the bone phenotype of Prkar1a+/- mice.

F. Faucz, C. Stratakis, S. Leikin, 2015, Human molecular genetics.

[Membrane fusion: local interactions and structural rearrangements].

M. Kozlov, V. Markin, L. Chernomordik, 1986, Doklady Akademii nauk SSSR.

Noncanonical ER–Golgi trafficking and autophagy of endogenous procollagen in osteoblasts

S. Leikin, S. Omari, E. Makareeva, 2021, Cellular and Molecular Life Sciences.

MBTPS2 mutations cause defective regulated intramembrane proteolysis in X-linked osteogenesis imperfecta

D. Eyre, I. Kennerknecht, A. Janecke, 2016, Nature Communications.

ER, Mitochondria, and ISR Regulation by mt‐HSP70 and ATF5 upon Procollagen Misfolding in Osteoblasts

Satoru Otsuru, S. Leikin, S. Omari, 2022, Advanced science.

Elastic properties of interfaces. Elasticity moduli and spontaneous geometric characteristics

M. Kozlov, V. Markin, S. Leikin, 1989 .

Kuskokwim Syndrome, a Recessive Congenital Contracture Disorder, Extends the Phenotype of FKBP10 Mutations

S. Bale, M. Gambello, D. Eyre, 2013, Human mutation.

Interactions of inorganic phosphate and sulfate anions with collagen.

S. Leikin, E. L. Mertz, 2004, Biochemistry.

Sugars and polyols inhibit fibrillogenesis of type I collagen by disrupting hydrogen-bonded water bridges between the helices.

S. Leikin, N. Kuznetsova, N Kuznetsova, 1998, Biochemistry.

Temperature-favoured assembly of collagen is driven by hydrophilic not hydrophobic interactions

V. Parsegian, S. Leikin, D. Rau, 1995, Nature Structural Biology.

Temperature-Dependent DNA Condensation Triggered by Rearrangement of Adsorbed Cations

Andrey G. Cherstvy, A. Kornyshev, S. Leikin, 2002 .

Bone Formation in 2D Culture of Primary Cells

S. Leikin, E. L. Mertz, E. Makareeva, 2022, JBMR plus.

Collagen degradation by tumor-associated trypsins.

T. Salo, O. Itkonen, H. Koistinen, 2013, Archives of biochemistry and biophysics.

Evidence of biomechanical and collagen heterogeneity in uterine fibroids

Betty S. Liu, S. Leikin, P. Leppert, 2019, PloS one.

Pulse-chase analysis of procollagen biosynthesis by azidohomoalanine labeling

S. Leikin, E. Makareeva, L. Mirigian, 2014, Connective tissue research.

Abnormal Type I Collagen Post-translational Modification and Crosslinking in a Cyclophilin B KO Mouse Model of Recessive Osteogenesis Imperfecta

K. Tomer, M. Yamauchi, D. Eyre, 2014, PLoS genetics.

Electrostatic interaction between long, rigid helical macromolecules at all interaxial angles.

A. Kornyshev, S. Leikin, 1999, Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics.

Carcinomas contain a matrix metalloproteinase-resistant isoform of type I collagen exerting selective support to invasion.

Sejin Han, Dan L Sackett, J. Vera, 2010, Cancer research.

Helical coherence of DNA in crystals and solution

A. Kornyshev, S. Leikin, A. Wynveen, 2008, Nucleic acids research.

Alternate protein kinase A activity identifies a unique population of stromal cells in adult bone

C. Cheadle, C. Stratakis, M. Collins, 2010, Proceedings of the National Academy of Sciences.

Theory of interaction between helical molecules

A. Kornyshev, S. Leikin, 1997 .

Fluctuations and interactions of semi-flexible polyelectrolytes in columnar assemblies

D. Lee, S. Leikin, A. Wynveen, 2010, Journal of physics. Condensed matter : an Institute of Physics journal.

Chiral electrostatic interaction and cholesteric liquid crystals of DNA

A. Kornyshev, S. Leikin, S. Malinin, 2002 .

Helical structure determines different susceptibilities of dsDNA, dsRNA, and tsDNA to counterion-induced condensation.

A. Kornyshev, S. Leikin, 2013, Biophysical journal.

Undulations enhance the effect of helical structure on DNA interactions.

A. Kornyshev, D. Lee, S. Leikin, 2010, The journal of physical chemistry. B.

Direct observation of azimuthal correlations between DNA in hydrated aggregates.

A. Kornyshev, S. Leikin, A. Wynveen, 2005, Physical review letters.

Torsional deformation of double helix in interaction and aggregation of DNA.

Andrey G. Cherstvy, A. Kornyshev, S. Leikin, 2004, The journal of physical chemistry. B.

Sequence recognition in the pairing of DNA duplexes.

A. Kornyshev, S. Leikin, A A Kornyshev, 2001, Physical review letters.

On the theory of electrostatic interaction of neutral lipid bilayers separated by thin water film

S. Leikin, 1991 .

Theory of hydration forces. Nonlocal electrostatic interaction of neutral surfaces

S. Leikin, A. Kornyshev, 1990 .

Segregation of type I collagen homo- and heterotrimers in fibrils.

Wolfgang Losert, Sejin Han, W. Losert, 2008, Journal of molecular biology.

Procollagen Trafficking and its Implications in Osteogenesis Imperfecta

S. Leikin, S. Omari, E. Makareeva, 2021 .

Mechanisms of procollagen and HSP47 sorting during ER-to-Golgi trafficking.

J. Lippincott-Schwartz, M. Jarnik, S. Leikin, 2020, Matrix biology : journal of the International Society for Matrix Biology.

Noncanonical autophagy at ER exit sites regulates procollagen turnover

J. Lippincott-Schwartz, M. Jarnik, S. Leikin, 2018, Proceedings of the National Academy of Sciences.

The chaperone activity of 4PBA ameliorates the skeletal phenotype of Chihuahua, a zebrafish model for dominant osteogenesis imperfecta

S. Fisher, J. Schwartz, K. Tian, 2017, Human molecular genetics.

Stalk mechanism of vesicle fusion

M. Kozlov, V. Markin, L. Chernomordik, 1989, European Biophysics Journal.

Membrane fusion: overcoming of the hydration barrier and local restructuring.

M. Kozlov, V. Markin, L. Chernomordik, 1987, Journal of theoretical biology.

Distinct type I collagen alterations cause intrinsic lung and respiratory defects of variable severity in mouse models of osteogenesis imperfecta

Satoru Otsuru, S. Leikin, J. Carroll, 2022, The Journal of physiology.

COL1A1 C-propeptide mutations cause ER mislocalization of procollagen and impair C-terminal procollagen processing.

D. Eyre, S. Leikin, A. Ashok, 2019, Biochimica et biophysica acta. Molecular basis of disease.

Collagen Structure, Folding and Function

S. Leikin, E. Makareeva, 2014 .

Chaperoning osteogenesis: new protein-folding disease paradigms.

S. Leikin, E. Makareeva, Nydea A Aviles, 2011, Trends in cell biology.

Electrostatic braiding and homologous pairing of DNA double helices.

Alexei A Kornyshev, Ruggero Cortini, A. Kornyshev, 2011, Biophysical journal.

DNA double helices recognize mutual sequence homology in a protein free environment.

Geoff S Baldwin, Alexei A Kornyshev, Arach Goldar, 2008, The journal of physical chemistry. B.

Symmetry laws for interaction between helical macromolecules.

A. Kornyshev, S. Leikin, Sergey Leikin, 1998, Biophysical journal.

Temperature‐induced complementarity as a mechanism for biomolecular assembly

V. Parsegian, S. Leikin, 1994, Proteins.

Molecular Mechanism of Type I Collagen Homotrimer Resistance to Mammalian Collagenases*

Wolfgang Losert, Sejin Han, W. Losert, 2010, The Journal of Biological Chemistry.

Changes in thermal stability and microunfolding pattern of collagen helix resulting from the loss of alpha2(I) chain in osteogenesis imperfecta murine.

S. Leikin, N. Kuznetsova, Sergey Leikin, 2003, Journal of molecular biology.

Molecular mechanism of alpha 1(I)-osteogenesis imperfecta/Ehlers-Danlos syndrome: unfolding of an N-anchor domain at the N-terminal end of the type I collagen triple helix.

S. Leikin, J. Marini, Sergey Leikin, 2006, The Journal of biological chemistry.

Substitutions for arginine at position 780 in triple helical domain of the α1(I) chain alter folding of the type I procollagen molecule and cause osteogenesis imperfecta

P. Byers, J. Vera, S. Leikin, 2018, PloS one.

Signatures of DNA flexibility, interactions and sequence-related structural variations in classical X-ray diffraction patterns

A. A. Kornyshev, A. Kornyshev, D. Lee, 2011, Nucleic acids research.

Measurement of Forces between Hydroxypropylcellulose Polymers: Temperature Favored Assembly and Salt Exclusion

V. Parsegian, S. Leikin, A. Rau, 2001 .

Osteogenesis imperfecta murine: interaction between type I collagen homotrimers.

S. Leikin, N. Kuznetsova, D J McBride, 2001, Journal of molecular biology.

Defective C-propeptides of the Proα2(I) Chain of Type I Procollagen Impede Molecular Assembly and Result in Osteogenesis Imperfecta*

P. Byers, S. Leikin, U. Schwarze, 2008, Journal of Biological Chemistry.

P4HA1 mutations cause a unique congenital disorder of connective tissue involving tendon, bone, muscle and the eye

M. Lek, C. Bönnemann, M. Deardorff, 2017, Human molecular genetics.

Surface phase transitions and hydration forces

A. Kornyshev, S. Leikin, D. Kossakowski, 1992 .

Structural Heterogeneity of Type I Collagen Triple Helix and Its Role in Osteogenesis Imperfecta*

Joan C. Marini, S. Leikin, M. Sutter, 2008, Journal of Biological Chemistry.

Overscreening in a polar liquid as a result of coupling between polarization and density fluctuations

A. Kornyshev, S. Leikin, G. Sutmann, 1997 .

Theory of Hydration Forces

S. Leikin, A. Kornyshev, 1992 .

Direct measurement of forces between self-assembled proteins: temperature-dependent exponential forces between collagen triple helices.

V. Parsegian, S. Leikin, D. Rau, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Twist in chiral interaction between biological helices.

A. Kornyshev, S. Leikin, 1999, Physical review letters.

Localization of nonlinear waves in randomly inhomogeneous media

S. Leikin, A. Gurevich, R. Mints, 1984 .

4PBA reduces growth deficiency in osteogenesis imperfecta by enhancing transition of hypertrophic chondrocytes to osteoblasts

A. Suzuki, T. Kaito, Satoru Otsuru, 2022, JCI insight.

Bending rigidity of type I collagen homotrimer fibrils

W. Losert, S. Leikin, R. Visse, 2009 .

Variable Bone Fragility Associated With an Amish COL1A2 Variant and a Knock-in Mouse Model

Steven A Goldstein, John D Sorkin, S. Goldstein, 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Procollagen Triple Helix Assembly: An Unconventional Chaperone-Assisted Folding Paradigm

S. Leikin, E. Makareeva, 2007, PloS one.

Structure, stability and interactions of type I collagen with GLY349-CYS substitution in alpha 1(I) chain in a murine Osteogenesis Imperfecta model.

S. Leikin, A. Forlino, J. Marini, 2004, Matrix biology : journal of the International Society for Matrix Biology.

Endoplasmic reticulum stress is induced in growth plate hypertrophic chondrocytes in G610C mouse model of osteogenesis imperfecta.

T. Kaito, Satoru Otsuru, J. Abzug, 2019, Biochemical and biophysical research communications.

Kuskokwim Syndrome, a Recessive Congenital Contracture Disorder, Extends the Phenotype of FKBP10 Mutations

S. Bale, M. Gambello, D. Eyre, 2013, Human mutation.

Molecular Mechanism of α1(I)-Osteogenesis Imperfecta/Ehlers-Danlos Syndrome

S. Leikin, J. Marini, E. Makareeva, 2006, Journal of Biological Chemistry.

Corrigendum: Prolyl 3-hydroxylase 1 deficiency causes a recessive metabolic bone disorder resembling lethal/severe osteogenesis imperfecta

C. Tifft, Peter A. Smith, D. Eyre, 2008, Nature Genetics.