S. Ullrich

发表

Glucose homeostasis is regulated by pancreatic β-cell cilia via endosomal EphA-processing

A. Fritsche, H. Häring, Francesco Volta, 2019, Nature Communications.

Adequate Connexin-mediated Is Required for Proper Insulin Production

L. Orci, P. Meda, S. Ullrich, 1995 .

Protein Kinase C Delta (PKCδ) Affects Proliferation of Insulin-Secreting Cells by Promoting Nuclear Extrusion of the Cell Cycle Inhibitor p21Cip1/WAF1

D. Hildebrand, K. Schulze-Osthoff, F. Bosch, 2011, PloS one.

Quinine inhibits Ca2+‐independent K+ channels whereas tetraethylammonium inhibits Ca2+‐activated K+ channels in insulin‐secreting cells

O. Petersen, C. Wollheim, O. Petersen, 1985, FEBS letters.

Conjugated Linoleic Acids Mediate Insulin Release through Islet G Protein-coupled Receptor FFA1/GPR40*

Evi Kostenis, Trond Ulven, Manuel Grundmann, 2011, The Journal of Biological Chemistry.

Mice Lacking Free Fatty Acid Receptor 1 (GPR40/FFAR1) are Protected Against Conjugated Linoleic Acid-Induced Fatty Liver but Develop Inflammation and Insulin Resistance in the Brain

E. Kostenis, H. Häring, C. Weigert, 2015, Cellular Physiology and Biochemistry.

Detection of free fatty acid receptor 1 expression: the critical role of negative and positive controls

E. Kostenis, H. Häring, S. Ullrich, 2014, Diabetologia.

Serum- and glucocorticoid-inducible kinase 1 (SGK1) mediates glucocorticoid-induced inhibition of insulin secretion.

D. Alexander, F. Lang, Dietmar Kuhl, 2005, Diabetes.

Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA(1)/GPR40), a potential target for the treatment of type II diabetes.

E. Kostenis, A. Bond, S. Ullrich, 2008, Journal of medicinal chemistry.

Epinephrine-induced hyperpolarization of islet cells without KATP channels.

J. Bryan, L. Aguilar-Bryan, S. Ullrich, 2004, American journal of physiology. Endocrinology and metabolism.

Pseudomonas aeruginosa activates Cl− channels in host epithelial cells

F. Lang, G. Pier, S. Ullrich, 2003, Pflügers Archiv.

Inhibition of insulin secretion via distinct signaling pathways in alpha2-adrenoceptor knockout mice.

M. Brede, S. Ullrich, L. Hein, 2003, European journal of endocrinology.

Effects of glucose, forskolin and tolbutamide on membrane potential and insulin secretion in the insulin-secreting cell line INS-1

S. Ullrich, R. Greger, Kirsten-Berit Abel, 1996, Pflügers Archiv - European Journal of Physiology.

Topography of mammalian connexins in human skin.

J. Saurat, D. Salomon, P. Meda, 1994, The Journal of investigative dermatology.

The impact of genetic variation in the G6PC2 gene on insulin secretion depends on glycemia.

D. Boomsma, E. D. de Geus, G. Nijpels, 2010, The Journal of clinical endocrinology and metabolism.

The Akt inhibitor triciribine sensitizes prostate carcinoma cells to TRAIL‐induced apoptosis

S. Wesselborg, R. Lammers, S. Ullrich, 2009, International journal of cancer.

Regulation of exocytosis in electrically permeabilized insulin-secreting cells. Evidence for Ca2+ dependent and independent secretion

P. Meda, C. Wollheim, S. Ullrich, 1987, Bioscience reports.

Reevaluation of Fatty Acid Receptor 1 as a Drug Target for the Stimulation of Insulin Secretion in Humans

E. Kostenis, A. Fritsche, H. Häring, 2013, Diabetes.

Impact of the Adipokine Adiponectin and the Hepatokine Fetuin-A on the Development of Type 2 Diabetes: Prospective Cohort- and Cross-Sectional Phenotyping Studies

F. Hu, M. Schulze, F. Schick, 2014, PloS one.

Serum- and Glucocorticoid-Inducible Kinase 1 Mediates Salt Sensitivity of Glucose Tolerance

F. Artunc, F. Lang, Dietmar Kuhl, 2006, Diabetes.

Peroxisome proliferator-activated receptor gamma (PPARG) modulates free fatty acid receptor 1 (FFAR1) dependent insulin secretion in humans

N. Stefan, M. Heni, A. Fritsche, 2014, Molecular metabolism.

Metabolomic Characteristics of Fatty Pancreas

N. Stefan, J. Machann, M. Heni, 2018, Experimental and Clinical Endocrinology & Diabetes.

Ceramide formation as a target in beta-cell survival and function

F. Lang, E. Gulbins, S. Ullrich, 2011, Expert opinion on therapeutic targets.

Pancreatic fat cells of humans with type 2 diabetes display reduced adipogenic and lipolytic activity.

J. Machann, F. Fend, M. Heni, 2021, American journal of physiology. Cell physiology.

Effects of IKs channel inhibitors in insulin-secreting INS-1 cells

F. Ris, F. Lang, U. Gerlach, 2005, Pflügers Archiv.

Expression of both alpha 1- and alpha 2-adrenoceptors in an insulin-secreting cell line. Parallel studies of cytosolic free Ca2+ and insulin release.

C. Wollheim, S. Ullrich, 1985, Molecular pharmacology.

GTP-dependent inhibition of insulin secretion by epinephrine in permeabilized RINm5F cells. Lack of correlation between insulin secretion and cyclic AMP levels.

C. Wollheim, S. Ullrich, C. Wollheim, 1988, The Journal of biological chemistry.

Adrenaline inhibits depolarization‐induced increases in capacitance in the presence of elevated [Ca2+]i in insulin secreting cells

M. Herbst, S. Ullrich, R. Greger, 1997, FEBS letters.

Enhanced insulin sensitivity of gene-targeted mice lacking functional KCNQ1.

E. Schleicher, D. Häussinger, F. Lang, 2009, American journal of physiology. Regulatory, integrative and comparative physiology.

Palmitate and insulin counteract glucose-induced thioredoxin interacting protein (TXNIP) expression in insulin secreting cells via distinct mechanisms

A. Schürmann, H. Häring, F. Gerst, 2018, PloS one.

Dexamethasone increases Na+/K+ ATPase activity in insulin secreting cells through SGK1.

F. Lang, Dietmar Kuhl, Ying Zhang, 2007, Biochemical and biophysical research communications.

Fenamates as TRP channel blockers: mefenamic acid selectively blocks TRPM3

C. Harteneck, W. Meyerhof, D. Krautwurst, 2011, British journal of pharmacology.

Regulation of calcineurin activity in insulin-secreting cells: stimulation by Hsp90 during glucocorticoid-induced apoptosis.

F. Lang, S. Wesselborg, H. Häring, 2008, Cellular signalling.

Characterization of small-molecular-mass guanine-nucleotide-binding regulatory proteins in insulin-secreting cells and PC12 cells.

C. Wollheim, Y. Takai, S. Ullrich, 1992, European journal of biochemistry.

Structure-Activity Study of Dihydrocinnamic Acids and Discovery of the Potent FFA1 (GPR40) Agonist TUG-469.

K. Kristiansen, E. Kostenis, S. Ullrich, 2010, ACS medicinal chemistry letters.

cAMP-activated protein kinase-independent potentiation of insulin secretion by cAMP is impaired in SUR1 null islets.

J. Bryan, L. Aguilar-Bryan, S. Ullrich, 2002, Diabetes.

IGF-1 Protects Against Dexamethasone-Induced Cell Death in Insulin Secreting INS-1 Cells Independent of AKT/PKB Phosphorylation

F. Lang, H. Häring, A. Hennige, 2008, Cellular Physiology and Biochemistry.

Glyceraldehyde, but not cyclic AMP‐stimulated insulin release is preceded by a rise in cytosolic free Ca2+

T. Pozzan, C. Wollheim, S. Ullrich, 1984, FEBS letters.

Overexpression of Kinase-Negative Protein Kinase Cδ in Pancreatic β-Cells Protects Mice From Diet-Induced Glucose Intolerance and β-Cell Dysfunction

F. Bosch, D. Michael, H. Häring, 2009, Diabetes.

Effects of adrenergic-stimulated lipolysis and cytokine production on in vitro mouse adipose tissue–islet interactions

A. Birkenfeld, R. Wagner, F. Gerst, 2022, Scientific Reports.

Sphingomyelinase dependent apoptosis following treatment of pancreatic beta-cells with amyloid peptides Aß1-42 or IAPP

F. Lang, M. Föller, Ying Zhang, 2009, Apoptosis.

Potentiation of stimulus-induced insulin secretion in protein kinase C-deficient RINm5F cells.

C. Wollheim, S. Ullrich, G. Li, 1990, The Biochemical journal.

Epinephrine‐induced hyperpolarization of pancreatic islet cells is sensitive to PI3K–PDK1 signaling

F. Lang, Ying Zhang, H. Häring, 2009, FEBS letters.

Fostering improved human islet research: a European perspective

M. McCarthy, L. Groop, R. Scharfmann, 2019, Diabetologia.

Membrane potential dependent modulations of calcium oscillations in insulin-secreting INS-1 cells.

M. Herbst, J. Hescheler, S. Ullrich, 2002, Cell calcium.

Glucose Responsiveness of β-Cells Depends on Fatty Acids

E. Schleicher, H. Häring, F. Gerst, 2019, Experimental and Clinical Endocrinology & Diabetes.

Islet cyclic AMP levels are not lowered during alpha 2-adrenergic inhibition of insulin release.

C. Wollheim, S. Ullrich, 1984, The Journal of biological chemistry.

Effects of I(Ks) channel inhibitors in insulin-secreting INS-1 cells.

F. Ris, F. Lang, U. Gerlach, 2005, Pflugers Archiv : European journal of physiology.

The KATP Channel is Critical for Calcium Sequestration into Non-ER Compartments in Mouse Pancreatic Beta Cells

J. Bryan, L. Aguilar-Bryan, S. Ullrich, 2006, Cellular Physiology and Biochemistry.

The expression and regulation of depolarization-activated K+ channels in the insulin-secreting cell line INS-1

Huang Yu, J. Hescheler, N. Lenka, 2001, Pflügers Archiv.

Somatostatin inhibition of hormone release: effects on cytosolic Ca++ and interference with distal secretory events.

C. Wollheim, W. Schlegel, S. Ullrich, 1990, Metabolism: clinical and experimental.

Postreceptor signalling of growth hormone and prolactin and their effects in the differentiated insulin-secreting cell line, INS-1.

C. Wollheim, N. Sekine, S. Ullrich, 1996, Endocrinology.

Different requirements for protein kinase C activation and Ca2+-independent insulin secretion in response to guanine nucleotides. Endogenously generated diacylglycerol requires elevated Ca2+ for kinase C insertion into membranes.

C. Wollheim, S. Ullrich, G. Li, 1989, The Journal of biological chemistry.

Activation of Extracellular Signal-Regulated Protein Kinases 1 and 2 (ERK1/2) by Free Fatty Acid Receptor 1 (FFAR1/GPR40) Protects from Palmitate-Induced Beta Cell Death, but Plays no Role in Insulin Secretion

H. Häring, R. Wagner, F. Gerst, 2015, Cellular Physiology and Biochemistry.

Galanin inhibits insulin secretion by direct interference with exocytosis

C. Wollheim, S. Ullrich, 1989, FEBS letters.

Characterization of alpha 2-adrenoceptors in a plasma membrane enriched fraction from the insulin-secreting cell line RINm5F.

C. Wollheim, S. Ullrich, 1989, Acta endocrinologica.

Effects of Adrenaline and Tolbutamide on Insulin Secretion in INS-1 Cells Under Voltage Control

M. Herbst, S. Ullrich, J. Kampermann, 2000, Cellular Physiology and Biochemistry.

Sunitinib specifically augments glucose-induced insulin secretion.

H. Häring, F. Gerst, S. Ullrich, 2017, Cellular signalling.

Redistribution of ADP-ribosylation factor during stimulation of permeabilized cells with GTP analogues.

R. Kahn, C. Wollheim, S. Ullrich, 1991, The Biochemical journal.

EPC syntheses and structure-activity relationships of hypoglycaemic semicyclic amidines.

S. Ullrich, C. Hupfer, A. Frahm, 2000, European journal of medicinal chemistry.

T-helper-1-cell cytokines drive cancer into senescence

L. Zender, M. Schaller, K. Schulze-Osthoff, 2013, Nature.

Glucose, adrenaline and palmitate antagonistically regulate insulin and glucagon secretion in human pseudoislets

H. Häring, U. Deschl, F. Gerst, 2019, Scientific Reports.

Adrenaline-, not somatostatin-induced hyperpolarization is accompanied by a sustained inhibition of insulin secretion in INS-1 cells. Activation of sulphonylurea KATP+ channels is not involved

S. Ullrich, Kirsten-Berit Abel, Sabine Lehr, 1996, Pflügers Archiv.

Adequate connexin-mediated coupling is required for proper insulin production

L. Orci, A. Charollais, P. Meda, 1995, The Journal of cell biology.

Untangling the interplay of genetic and metabolic influences on beta-cell function: Examples of potential therapeutic implications involving TCF7L2 and FFAR1☆

N. Stefan, A. Fritsche, H. Häring, 2014, Molecular metabolism.

Metabolic implications of pancreatic fat accumulation

J. Machann, M. Solimena, A. Schürmann, 2021, Nature Reviews Endocrinology.

The hepatokine fetuin-A disrupts functional maturation of pancreatic beta cells

E. Wolf, N. Stefan, F. Fend, 2021, Diabetologia.

Glucose‐induced insulin secretion: is the small G‐protein Rab27A the mediator of the KATP channel‐independent effect?

S. Ullrich, 2008, The Journal of physiology.

FFA2-, but not FFA3-agonists inhibit GSIS of human pseudoislets: a comparative study with mouse islets and rat INS-1E cells

E. Kostenis, H. Häring, A. Birkenfeld, 2020, Scientific Reports.

Metabolic crosstalk between fatty pancreas and fatty liver: effects on local inflammation and insulin secretion

N. Stefan, J. Machann, B. Sipos, 2017, Diabetologia.

Somatostatin inhibition of Ca2(+)-induced insulin secretion in permeabilized HIT-T15 cells.

M. Prentki, C. Wollheim, S. Ullrich, 1990, The Biochemical journal.

What role do fat cells play in pancreatic tissue?

M. Heni, A. Fritsche, H. Häring, 2019, Molecular metabolism.

35th Annual meeting of the European Association for the Study of Diabetes. Brussels, Belgium, 28 September-2 October, 1999. Abstracts.

Thomas J. Smith, B. M. Rasmussen, V. C. Phan, 1999, Diabetologia.

IGF-1 and Insulin-Receptor Signalling in Insulin-Secreting Cells: From Function to Survival 23

S. Ullrich, 2015 .

Loss of Annexin A7 Leads to Alterations in Frequency-Induced Shortening of Isolated Murine Cardiomyocytes

B. Fleischmann, A. Noegel, R. Schwinger, 2001, Molecular and Cellular Biology.

Protein kinase Cδ regulates nuclear export of FOXO1 through phosphorylation of the chaperone 14-3-3ζ

F. Bosch, H. Häring, A. Pujol, 2015, Diabetologia.

Resistance of mice lacking the serum- and glucocorticoid-inducible kinase SGK1 against salt-sensitive hypertension induced by a high-fat diet.

F. Artunc, F. Lang, Dietmar Kuhl, 2006, American journal of physiology. Renal physiology.

Dexamethasone Induces Cell Death in Insulin-Secreting Cells, an Effect Reversed by Exendin-4

F. Lang, S. Ullrich, M. Düfer, 2006, Diabetes.

Pancreatic Steatosis Associates With Impaired Insulin Secretion in Genetically Predisposed Individuals

F. Schick, J. Machann, F. Fend, 2020, The Journal of clinical endocrinology and metabolism.

Discovery of TUG-770: A Highly Potent Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist for Treatment of Type 2 Diabetes

B. Hudson, G. Milligan, E. Kostenis, 2013, ACS medicinal chemistry letters.

Analysis of cellular interactions in density-dependent inhibition of 3T3 Cell proliferation

S. Ullrich, G. Adam, U. Steiner, 2004, Biophysics of structure and mechanism.

Fetuin-A influences vascular cell growth and production of proinflammatory and angiogenic proteins by human perivascular fat cells

N. Stefan, U. Stock, H. Häring, 2014, Diabetologia.

Identification of a potent and selective free fatty acid receptor 1 (FFA1/GPR40) agonist with favorable physicochemical and in vitro ADME properties.

L. Pardo, E. Kostenis, S. Ullrich, 2011, Journal of medicinal chemistry.

Common polymorphisms within the NR4A3 locus, encoding the orphan nuclear receptor Nor-1, are associated with enhanced β-cell function in non-diabetic subjects

M. Laakso, N. Stefan, A. Stančáková, 2009, BMC Medical Genetics.

Glucose-stimulated insulin secretion depends on FFA1 and Gq in neonatal mouse islets

E. Kostenis, H. Häring, A. Birkenfeld, 2023, Diabetologia.

Point mutation of Ffar1 abrogates fatty acid-dependent insulin secretion, but protects against HFD-induced glucose intolerance

Gerhard K. H. Przemeck, H. Häring, M. Hoene, 2017, Molecular metabolism.

SGK1-Dependent Upregulation of Connective Tissue Growth Factor by Angiotensin II

T. Risler, F. Lang, Dietmar Kuhl, 2008, Kidney and Blood Pressure Research.

The Expression of Aldolase B in Islets Is Negatively Associated With Insulin Secretion in Humans

M. Solimena, A. Schürmann, D. Richter, 2018, The Journal of clinical endocrinology and metabolism.

Intracellular multiplication of Legionella pneumophila depends on host cell amino acid transporter SLC1A5

B. Neumeister, F. Lang, S. Ullrich, 2005, Molecular microbiology.

Nor-1, a novel incretin-responsive regulator of insulin genes and insulin secretion.

N. Stefan, O. Rothfuss, M. Heni, 2013, Molecular metabolism.

Variance of the SGK1 Gene Is Associated with Insulin Secretion in Different European Populations: Results from the TUEF, EUGENE2, and METSIM Studies

T. Hansen, O. Pedersen, M. Laakso, 2008, PloS one.

Gland cell connexins

A. Charollais, P. Meda, D. Bosco, 1995 .

Regulation of forkhead box O1 (FOXO1) by protein kinase B and glucocorticoids: different mechanisms of induction of beta cell death in vitro

F. Lang, D. Michael, B. Friedrich, 2013, Diabetologia.