C. Leng

发表

Molecular Mechanisms of TLR2-Mediated Antigen Cross-Presentation in Dendritic Cells

P. Chong, K. Shen, Ying C. Song, 2014, The Journal of Immunology.

Cells Antigen Cross-Presentation in Dendritic Molecular Mechanisms of TLR2-Mediated

P. Chong, K. Shen, Ying C. Song, 2014 .

HLA-A∗0201 T-cell epitopes in severe acute respiratory syndrome (SARS) coronavirus nucleocapsid and spike proteins

J. Jan, Yuh‐Cheng Yang, Y. Tsao, 2006, Biochemical and Biophysical Research Communications.

Truncated Pneumolysin from Streptococcus pneumoniae as a TLR4-Antagonizing New Drug for Chronic Inflammatory Conditions

Shun-Fu Chang, P. Chong, C. Leng, 2020, Cells.

Self-polymerization of archaeal RadA protein into long and fine helical filaments.

C. Chou, A. H. Wang, C. Leng, 2004, Biochemical and biophysical research communications.

Disintegration and cancer immunotherapy efficacy of a squalane-in-water delivery system emulsified by bioresorbable poly(ethylene glycol)-block-polylactide.

P. Chong, C. Leng, Hsin-Wei Chen, 2014, Biomaterials.

A recombinant lipoprotein containing an unsaturated fatty acid activates NF-kappaB through the TLR2 signaling pathway and induces a differential gene profile from a synthetic lipopeptide.

Y. Sher, Shu-Pei Lien, P. Chong, 2010, Molecular immunology.

Recombinant Lipoproteins as Novel Vaccines with Intrinsic Adjuvant.

Jui-Hsin Huang, P. Chong, C. Leng, 2015, Advances in protein chemistry and structural biology.

Induction of robust immunity by the emulsification of recombinant lipidated dengue-1 envelope protein domain III.

P. Chong, C. Leng, Hsin-Wei Chen, 2013, Microbes and infection.

A novel technology for the production of a heterologous lipoprotein immunogen in high yield has implications for the field of vaccine design.

P. Chong, C. Leng, Hsin-Wei Chen, 2009, Vaccine.

Presentation of lipopeptide by dendritic cells induces anti‐tumor responses via an endocytosis‐independent pathway in vivo

P. Chong, M. Tao, K. Shen, 2011, Journal of leukocyte biology.

Self-adjuvanting lipoimmunogens for therapeutic HPV vaccine development: potential clinical impact

K. Shen, C. Leng, Shih-Jen Liu, 2015, Expert review of vaccines.

Generating stable chinese hamster ovary cell clones to produce a truncated SARS‐CoV spike protein for vaccine development

Suh-Chin Wu, Shih-Chang Lin, C. Leng, 2010, Biotechnology progress.

Identification of Immunoreactive Peptides of Toxins to Simultaneously Assess the Neutralization Potency of Antivenoms against Neurotoxicity and Cytotoxicity of Naja atra Venom

Suh-Chin Wu, W. Sung, C. Leng, 2017, Toxins.

Polysorbasome: A Colloidal Vesicle Contoured by Polymeric Bioresorbable Amphiphiles as an Immunogenic Depot for Vaccine Delivery.

P. Chong, C. Leng, Hsin-Wei Chen, 2018, ACS applied materials & interfaces.

Delivery of Antigen to CD8+ Dendritic Cells by Fusing Antigen With Formyl Peptide Receptor-Like 1 Inhibitor Protein Induces Antitumor Immunity

C. Leng, Hsin-Wei Chen, Shih-Jen Liu, 2019, Front. Immunol..

A Toll-like receptor 2 agonist-fused antigen enhanced antitumor immunity by increasing antigen presentation and the CD8 memory T cells population

K. Shen, C. Leng, Hsin-Wei Chen, 2016, Oncotarget.

Influence of medium components on the expression of recombinant lipoproteins in Escherichia coli

C. Leng, Chi-Ling Tseng, 2012, Applied Microbiology and Biotechnology.

Domain 4 of pneumolysin from Streptococcus pneumoniae is a multifunctional domain contributing TLR4 activating and hemolytic activity.

Shu-Pei Lien, C. Leng, Hsin-Wei Chen, 2019, Biochemical and biophysical research communications.

Toll-like receptor 9 agonist enhances anti-tumor immunity and inhibits tumor-associated immunosuppressive cells numbers in a mouse cervical cancer model following recombinant lipoprotein therapy

C. Leng, Hsin-Wei Chen, Shih-Jen Liu, 2014, Molecular Cancer.

Biochemical and Immunological Characterization of Truncated Fragments of the Receptor-Binding Domains of C. difficile Toxin A

Shu-Pei Lien, Jui-Hsin Huang, P. Chong, 2015, PloS one.

Biochemical and Immunological Characterizations of the Receptor Binding Domain of C. difficile Toxin B

Shu-Pei Lien, Jui-Hsin Huang, P. Chong, 2015 .

Recombinant bacterial lipoproteins as vaccine candidates

P. Chong, C. Leng, Hsin-Wei Chen, 2015, Expert review of vaccines.

Rapid isolation and characterization of bacterial lipopeptides using liquid chromatography and mass spectrometry analysis

W. Sung, P. Chong, C. Leng, 2011, Proteomics.

Biochemical characterizations of Escherichia coli-expressed protective antigen Ag473 of Neisseria meningitides group B.

P. Chong, C. Leng, Shih-Jen Liu, 2010, Vaccine.

Emulsified Nanoparticles Containing Inactivated Influenza Virus and CpG Oligodeoxynucleotides Critically Influences the Host Immune Responses in Mice

P. Chong, C. Leng, Hsin-Wei Chen, 2010, PloS one.

Degradable emulsion as vaccine adjuvant reshapes antigen-specific immunity and thereby ameliorates vaccine efficacy

P. Chong, C. Leng, Hsin-Wei Chen, 2016, Scientific Reports.

Immunological study of HA1 domain of hemagglutinin of influenza H5N1 virus.

Chin-Cheng Huang, P. Chong, C. Leng, 2009, Biochemical and biophysical research communications.

Immunological study of HA 1 domain of hemagglutinin of influenza H 5 N 1 virus

Chin-Cheng Huang, P. Chong, C. Leng, 2009 .

Development of Multi-Phase Emulsions Based on Bioresorbable Polymers and Oily Adjuvant

Shu-Pei Lien, P. Chong, C. Leng, 2009, Pharmaceutical Research.

Enhancement of potent antibody and T-cell responses by a single-dose, novel nanoemulsion-formulated pandemic influenza vaccine.

P. Chong, C. Leng, Hsin-Wei Chen, 2009, Microbes and infection.

Immunogenic properties of RSV-B1 fusion (F) protein gene-encoding recombinant adenoviruses.

P. Chong, I. Chen, C. Leng, 2009, Vaccine.

Influence of medium components on the expression of recombinant lipoproteins in Escherichia coli

C. Leng, Chi-Ling Tseng, 2012, Applied Microbiology and Biotechnology.

An improved SUMO fusion protein system for effective production of native proteins

S. Liang, C. Leng, Ting-Fang Wang, 2008, Protein science : a publication of the Protein Society.

Immunological characterizations of the nucleocapsid protein based SARS vaccine candidates

Chi-Ju Chen, S. Hsieh, P. Chong, 2006, Vaccine.

Heterodimeric complexes of Hop2 and Mnd1 function with Dmc1 to promote meiotic homolog juxtaposition and strand assimilation.

A. H. Wang, H. Olivares, C. Leng, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Efficient Uptake of Recombinant Lipidated Survivin by Antigen-Presenting Cells Initiates Antigen Cross-Presentation and Antitumor Immunity

C. Leng, Hsin-Wei Chen, Shih-Jen Liu, 2018, Front. Immunol..

A Purified Recombinant Lipopeptide as Adjuvant for Cancer Immunotherapy

P. Chong, Ying C. Song, I. Chen, 2014, BioMed research international.

Immunogenicity of a novel tetravalent vaccine formulation with four recombinant lipidated dengue envelope protein domain IIIs in mice

P. Chong, C. Leng, Hsin-Wei Chen, 2016, Scientific Reports.

A novel dengue vaccine candidate that induces cross-neutralizing antibodies and memory immunity.

A. Yueh, P. Chong, C. Leng, 2009, Microbes and infection.

CpG-oligodeoxynucleotides developed for grouper toll-like receptor (TLR) 21s effectively activate mouse and human TLR9s mediated immune responses

C. Yuh, Ping-Hui Tseng, C. Leng, 2017, Scientific Reports.

S. cerevisiae Mre11 recruits conjugated SUMO moieties to facilitate the assembly and function of the Mre11-Rad50-Xrs2 complex

C. Leng, Ting-Fang Wang, Chuang-Rung Chang, 2016, Nucleic acids research.

Carboxyl-terminal fusion of E7 into Flagellin shifts TLR5 activation to NLRC4/NAIP5 activation and induces TLR5-independent anti-tumor immunity

C. Leng, Shih-Jen Liu, Kuo-Hsing Lin, 2016, Scientific Reports.

Whole brain radiation therapy followed by intensity-modulated boosting treatment combined with concomitant temozolomide for brain metastases from non-small-cell lung cancer

C. Leng, S. Lu, Shiyong Lu, 2014, Clinical and Translational Oncology.

Gemcitabine enhances antitumor efficacy of recombinant lipoimmunogen-based immunotherapy

C. Leng, Hsin-Wei Chen, Shih-Jen Liu, 2016, Oncoimmunology.

A novel emulsion-type adjuvant containing CpG oligodeoxynucleotides enhances CD8+ T-cell-mediated anti-tumor immunity.

P. Chong, Ying C. Song, C. Leng, 2014, Journal of controlled release : official journal of the Controlled Release Society.

Formulation and immunological evaluation of novel vaccine delivery systems based on bioresorbable poly(ethylene glycol)-block-poly(lactide-co-epsilon-caprolactone).

Pele Chong, P. Chong, C. Leng, 2009, Journal of biomedical materials research. Part B, Applied biomaterials.

Recombinant lipoprotein-based vaccine candidates against C. difficile infections

Jui-Hsin Huang, P. Chong, C. Leng, 2015, Journal of Biomedical Science.

Recombinant Lipidated HPV E7 Induces a Th-1-Biased Immune Response and Protective Immunity against Cervical Cancer in a Mouse Model

J. Chen, P. Chong, K. Shen, 2012, PloS one.

The Immunodominance Change and Protection of CD4+ T-Cell Responses Elicited by an Envelope Protein Domain III-Based Tetravalent Dengue Vaccine in Mice

P. Chong, C. Leng, Hsin-Wei Chen, 2015, PloS one.

Identification of HLA-A11-restricted CTL epitopes derived from HPV type 18 using DNA immunization

P. Chong, M. Tao, Ping-Yi Wu, 2009, Cancer biology & therapy.

The successful induction of T-cell and antibody responses by a recombinant measles virus-vectored tetravalent dengue vaccine provides partial protection against dengue-2 infection

P. Chong, C. Leng, Hsin-Wei Chen, 2016, Human vaccines & immunotherapeutics.

A novel liposomal recombinant lipoimmunogen enhances anti-tumor immunity.

K. Shen, C. Leng, Hui-Ju Li, 2016, Journal of controlled release : official journal of the Controlled Release Society.

Isolation and characterization of a DnaJ‐like protein in rats: The C‐terminal 10‐kDa domain of hsc70 is not essential for stimulating the ATP‐hydrolytic activity of hsc70 by a DnaJ‐like protein

J. Brodsky, C. Leng, Chung-Chun Wang, 1998, Protein science : a publication of the Protein Society.

A Novel Single-Dose Dengue Subunit Vaccine Induces Memory Immune Responses

P. Chong, C. Leng, Hsin-Wei Chen, 2011, PloS one.

Lipidated Dengue-2 Envelope Protein Domain III Independently Stimulates Long-Lasting Neutralizing Antibodies and Reduces the Risk of Antibody-Dependent Enhancement

P. Chong, C. Leng, Hsin-Wei Chen, 2013, PLoS neglected tropical diseases.

Solubilization, Characterization, and Partial Purification of α‐Amino‐3‐Hydroxy‐5‐Methyl‐4‐Isoxazolepropionic Acid‐, Quisqualate‐, Kainate‐Sensitive l‐Glutamate Binding Sites from Porcine Brain Synaptic Junctions

Yen-Chung Chang, C. Leng, Yih‐Hong Lin, 1991, Journal of neurochemistry.

Molecular visualization of the yeast Dmc1 protein ring and Dmc1-ssDNA nucleoprotein complex.

C. Leng, Yuan-Chih Chang, Ting-Fang Wang, 2005, Biochemistry.

Toll-like receptor 9 agonist enhances anti-tumor immunity and inhibits tumor-associated immunosuppressive cells numbers in a mouse cervical cancer model following recombinant lipoprotein therapy

C. Leng, Hsin-Wei Chen, Shih-Jen Liu, 2014, Molecular Cancer.

Identification of synthetic vaccine candidates against SARS CoV infection

P. Chong, C. Leng, Hsin-Wei Chen, 2007, Biochemical and Biophysical Research Communications.

A therapeutic vaccine targeting HPV E6/E7 with intrinsic Toll-like receptor 2 agonist activity induces antitumor immunity.

Y. Sher, I. Chen, C. Leng, 2018, American journal of cancer research.

Recombinant lipidated dengue-3 envelope protein domain III stimulates broad immune responses in mice.

P. Chong, I. Chen, C. Leng, 2016, Vaccine.

A consensus envelope protein domain III can induce neutralizing antibody responses against serotype 2 of dengue virus in non-human primates

Chin-Cheng Huang, P. Chong, C. Leng, 2013, Archives of Virology.

Dengue-1 Envelope Protein Domain III along with PELC and CpG Oligodeoxynucleotides Synergistically Enhances Immune Responses

P. Chong, C. Leng, Hsin-Wei Chen, 2012, PLoS neglected tropical diseases.

Recombinant lipoprotein-based vaccine candidates against C. difficile infections

Jui-Hsin Huang, P. Chong, C. Leng, 2015, Journal of Biomedical Science.

A novel technology for the production of a heterologous lipoprotein immunogen in high yield has implications for the field of vaccine design.

P. Chong, C. Leng, Hsin-Wei Chen, 2009, Vaccine.

A recombinant lipoprotein containing an unsaturated fatty acid activates NF-kappaB through the TLR2 signaling pathway and induces a differential gene profile from a synthetic lipopeptide.

Y. Sher, P. Chong, C. Leng, 2010, Molecular Immunology.

A broad-spectrum pneumococcal vaccine induces mucosal immunity and protects against lethal Streptococcus pneumoniae challenge

C. Leng, Ling-Ling Tu, Fang‐Feng Chiu, 2023, Emerging microbes & infections.

Molecular Mechanisms of TLR2-Mediated Antigen Cross-Presentation in Dendritic Cells

P. Chong, K. Shen, Ying C. Song, 2014, The Journal of Immunology.

Recombinant lipidated dengue-4 envelope protein domain III elicits protective immunity.

P. Chong, C. Leng, Hsin-Wei Chen, 2014, Vaccine.

Recombinant Lipoproteins as Novel Vaccines with Intrinsic Adjuvant.

Jui-Hsin Huang, P. Chong, C. Leng, 2015, Advances in protein chemistry and structural biology.