P. Conley

发表

Distinct Clathrin‐Coated Pits Sort Different G Protein‐Coupled Receptor Cargo

S. Mundell, J. Benovic, Jiansong Luo, 2006, Traffic.

REGULATED SYNTHESIS OF PHYCOBILISOME COMPONENTS

A. Grossman, P. Lemaux, P. Conley, 1986, Photochemistry and photobiology.

Pharmacokinetic and Pharmacodynamic Effects of Elinogrel: Results of the Platelet Function Substudy From the Intravenous and Oral Administration of Elinogrel to Evaluate Tolerability and Efficacy in Nonurgent Percutaneous Coronary Intervention Patients (INNOVATE-PCI) Trial

Sunil V. Rao, J. Wójcik, F. Neumann, 2012, Circulation. Cardiovascular Interventions.

Regulated expression of alpha 2,6-sialyltransferase by the liver-enriched transcription factors HNF-1, DBP, and LAP.

J. Paulson, E. Svensson, P. Conley, 1992, The Journal of biological chemistry.

Leukotriene E4–induced pulmonary inflammation is mediated by the P2Y12 receptor

S. Paruchuri, W. Xing, Yongfeng Jiang, 2009, The Journal of experimental medicine.

Distinct Roles for Protein Kinase C Isoforms in Regulating Platelet Purinergic Receptor Function

S. Mundell, P. Conley, A. Poole, 2006, Molecular Pharmacology.

P2Y1 and P2Y12 receptors for ADP desensitize by distinct kinase-dependent mechanisms.

S. Mundell, J. Benovic, Jiansong Luo, 2005, Blood.

P2Y1 and P2Y12 receptors for ADP desensitize by distinct kinase-dependent mechanisms.

S. Mundell, J. Benovic, Jiansong Luo, 2005, Blood.

Development of a perfusion chamber assay to study in real time the kinetics of thrombosis and the antithrombotic characteristics of antiplatelet drugs

C. Muir, P. Conley, D. Phillips, 2012, Thrombosis Journal.

Antiplatelet Therapies Targeting Thrombin Signaling Thrombin Signaling in Platelets

S. Steinhubl, R. Becker, M. Roe, 2009 .

Therapeutic approaches in arterial thrombosis

P. Conley, D. Phillips, U. Sinha, 2005, Journal of thrombosis and haemostasis : JTH.

Isolation and characterization of light-regulated phycobilisome linker polypeptide genes and their transcription as a polycistronic mRNA

A. Grossman, P. Conley, J. Schilling, 1987, Journal of bacteriology.

The ADP receptor P2RY12 regulates osteoclast function and pathologic bone remodeling.

J. Schneider, A. Hughes, T. Steinberg, 2012, The Journal of clinical investigation.

The Dual Syk/JAK Inhibitor Cerdulatinib Antagonizes B-cell Receptor and Microenvironmental Signaling in Chronic Lymphocytic Leukemia

Peter Johnson, M. Larrayoz, G. Packham, 2016, Clinical Cancer Research.

Cutting Edge: Leukotriene C4 Activates Mouse Platelets in Plasma Exclusively through the Type 2 Cysteinyl Leukotriene Receptor

Y. Kanaoka, Chunli Feng, J. Boyce, 2013, The Journal of Immunology.

Platelet aggregation induces platelet aggregate stability via SLAM family receptor signaling.

K. Clauser, P. Conley, D. Phillips, 2005, Blood.

Roles and interactions among protease-activated receptors and P2ry12 in hemostasis and thrombosis

S. Coughlin, T. David, L. Wilsbacher, 2010, Proceedings of the National Academy of Sciences.

A phase 2 PK/PD study of andexanet alfa for reversal of rivaroxaban and edoxaban anticoagulation in healthy volunteers.

J. Leeds, P. Conley, M. Karbarz, 2020, Blood advances.

Transient or extended reversal of apixaban anticoagulation by andexanet alfa is equally effective in a porcine polytrauma model.

R. Rossaint, J. Leeds, P. Conley, 2019, British journal of anaesthesia.

Safety, pharmacokinetics, and reversal of apixaban anticoagulation with andexanet alfa.

J. Leeds, P. Conley, M. Karbarz, 2017, Blood advances.

A Phase 2 Randomized, Double-Blind, Placebo-Controlled Trial Demonstrating Reversal Of Rivaroxaban-Induced Anticoagulation In Healthy Subjects By Andexanet Alfa (PRT064445), An Antidote For Fxa Inhibitors

S. Connolly, P. Conley, M. Karbarz, 2013 .

A Phase 2 Randomized, Double-Blind, Placebo-Controlled Trial Demonstrating Reversal of Edoxaban-Induced Anticoagulation in Healthy Subjects By Andexanet Alfa (PRT064445), a Universal Antidote for Factor Xa (fXa) Inhibitors

S. Connolly, J. Leeds, P. Conley, 2014 .

455: REVERSAL OF FACTOR XA INHIBITORS-INDUCED ANTICOAGULATION IN HEALTHY SUBJECTS BY ANDEXANET ALFA

S. Connolly, J. Leeds, P. Conley, 2014 .

Andexanet versus prothrombin complex concentrates: Differences in reversal of factor Xa inhibitors in in vitro thrombin generation

P. Conley, K. Bui, J. Curnutte, 2020, Research and practice in thrombosis and haemostasis.

Andexanet alfa effectively reverses edoxaban anticoagulation effects and associated bleeding in a rabbit acute hemorrhage model

J. Leeds, P. Conley, P. Pratikhya, 2018, PloS one.

Anticoagulants (Thrombin Inhibitors) and Aspirin Synergize With P2Y12 Receptor Antagonism in Thrombosis

P. Conley, D. Phillips, U. Sinha, 2003, Circulation.

Scientific and therapeutic insights into the role of the platelet P2Y12 receptor in thrombosis

P. Conley, S. Delaney, 2003, Current opinion in hematology.

Leukotriene E 4 – induced pulmonary inflammation is mediated by the P 2 Y 12 receptor

S. Paruchuri, W. Xing, Yongfeng Jiang, 2009 .

Impaired activation of murine platelets lacking

P. Conley, R. Mortensen, H. Jantzen, 2018 .

Impaired activation of murine platelets lacking Gαi2

P. Conley, R. Mortensen, H. Jantzen, 2001 .

Abstract 12420: Reversal of Low Molecular Weight Heparin and Fondaparinux by a Recombinant Antidote (r-Antidote, PRT064445)

P. Conley, P. Luan, D. Phillips, 2010 .

P2Y12 regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries.

P. Conley, D. Phillips, P. Andre, 2003, The Journal of clinical investigation.

Expression of a IIb b 3 Integrin ( GPIIb-IIIa ) in Myeloid Cell Lines and Normal CD 34 1 / CD 33 1 Bone Marrow Cells

J. Wagner, R. Raghow, L. Jennings, 1997 .

Expression of αIIbβ3 Integrin (GPIIb-IIIa) in Myeloid Cell Lines and Normal CD34+/CD33+ Bone Marrow Cells

J. Wagner, R. Raghow, L. Jennings, 1997 .

Changes in Accumulation and Synthesis of Transcripts Encoding Phycobilisome Components during Acclimation of Fremyella diplosiphon to Different Light Qualities.

N. Federspiel, A. Grossman, R. Oelmüller, 1988, Plant physiology.

Cyanobacterial light-harvesting complex subunits encoded in two red light-induced transcripts.

A. Grossman, P. Lemaux, P. Conley, 1985, Science.

Identification of P2Y12-dependent and -independent mechanisms of glycoprotein VI-mediated Rap1 activation in platelets.

L. Parise, Anne M Taylor, P. Conley, 2003, Blood.

HNF- 1 and HNF- 1 (vHNF- 1) share dimerization and homeo domains, but not activation domains, and form heterodimers in vitro

G. Crabtree, P. Conley, D. Mendel, 2007 .

Structure and expression of the human slow twitch skeletal muscle troponin I gene.

L. Kedes, O. Juhasz, P. Conley, 1994, The Journal of biological chemistry.

Comparison of reversal activity and mechanism of action of UHRA, andexanet, and PER977 on heparin and oral FXa inhibitors.

C. Haynes, A. Creagh, P. Conley, 2018, Blood advances.

Measuring residual anti‐Xa activity of direct factor Xa inhibitors after reversal with andexanet alfa

P. Conley, F. Depasse, G. Lu, 2021, International journal of laboratory hematology.

ANDEXANET ALFA FOR ACUTE BLEEDING DURING TREATMENT WITH ENOXAPARIN

S. Connolly, J. Eikelboom, T. Milling, 2021 .

Effects of Andexanet Alfa on Thrombin Generation in Bleeding Associated with Factor Xa Inhibitors

S. Connolly, J. Eikelboom, P. Verhamme, 2019, Blood.

Reversal of Heparin-Induced Anticoagulation By Andexanet Alfa, a Universal Antidote for Factor Xa Inhibitors

P. Conley, J. Curnutte, G. Lu, 2015 .

Abstract 14657: Andexanet-alfa and PER977 (Arapazine) Correct Blood Loss in a Rabbit Liver Laceration Model - Only Andexanet Reverses Markers of fXa-mediated Anticoagulation

P. Conley, P. Pratikhya, A. Pandey, 2014 .

ANNEXATM-R: A PHASE 3 RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL, DEMONSTRATING REVERSAL OF RIVAROXABAN-INDUCED ANTICOAGULATION IN OLDER SUBJECTS BY ANDEXANET ALFA (PRT064445), A UNIVERSAL ANTIDOTE FOR FACTOR XA (FXA) INHIBITORS

S. Connolly, J. Leeds, P. Conley, 2015 .

Abstract 18218: In Vitro Characterization of Andexanet Alfa (PRT064445), a Specific fXa Inhibitor Antidote versus Aripazine (PER977), a Non-specific Reversal Agent

L. Jennings, P. Conley, A. Pandey, 2014 .

Isolation and Characterization of Light-Regulated Phycobilisome Linker Polypeptide Genes and Their Transcription as a Polycistronic mRNAt

P. Conley, J. Schilling, T. Lomax, 2022 .

Genes encoding major light-harvesting polypeptides are clustered on the genome of the cyanobacterium Fremyella diplosiphon.

A. Grossman, P. Lemaux, P. Conley, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Impaired activation of murine platelets lacking Gαi2

P. Conley, R. Mortensen, H. Jantzen, 2001 .

Function by ADP Modulation of Murine Dendritic Cell Receptor in the 12 Role of the P2Y

P. Conley, J. Boeynaems, B. Robaye, 2010 .

Cerdulatinib Pharmacodynamics and Relationships to Tumor Response Following Oral Dosing in Patients with Relapsed/Refractory B-cell Malignancies

Sabah Kadri, Y. L. Wang, J. Leeds, 2017, Clinical Cancer Research.

Dual SYK/JAK inhibition overcomes ibrutinib resistance in chronic lymphocytic leukemia: Cerdulatinib, but not ibrutinib, induces apoptosis of tumor cells protected by the microenvironment

Y. L. Wang, P. Conley, A. Pandey, 2017, Oncotarget.

reversal of enoxaparin-induced anticoagulation in healthy subjects by andexanet alfa (prt064445), an antidote for direct and indirect fxa inhibitors—a phase 2 randomized, double-blind, placebo-controlled trial : Coa01

S. Connolly, J. Leeds, P. Conley, 2014 .

314 Reversal of Betrixaban-Induced Anticoagulation in Healthy Volunteers by Andexanet Alfa

S. Connolly, J. Leeds, P. Conley, 2017 .

Reversal of Betrixaban-Induced Anticoagulation in Healthy Volunteers By Andexanet Alfa

S. Connolly, J. Leeds, P. Conley, 2016 .

Andexanet Alfa, a Universal Antidote Under Development for Factor Xa Inhibitors, Reverses Rivaroxaban-Induced Inhibition of Thrombin Generation Initiated By the Intrinsic Coagulation Pathway Independent of TFPI

P. Conley, J. Curnutte, G. Lu, 2016 .

CalDAG-GEFI Deficiency Reduces Atherosclerotic Lesion Development in Mice

David S. Paul, C. Casari, N. Mackman, 2016, Arteriosclerosis, thrombosis, and vascular biology.

Novel Tricyclic Benzothiazolo[2,3-c]thiadiazine Antagonists of the Platelet ADP Receptor (P2Y12).

P. Conley, L. Fretto, R. Scarborough, 2001 .

Novel tricyclic benzothiazolo[2,3-c]thiadiazine antagonists of the platelet ADP receptor (P2Y(12)).

P. Conley, L. Fretto, R. Scarborough, 2001, Bioorganic & medicinal chemistry letters.

Characterization of a cofactor that regulates dimerization of a mammalian homeodomain protein.

G. Crabtree, P. Khavari, A. Admon, 1991, Science.

Molecular cloning, functional expression, and chromosomal localization of mouse hepatocyte nuclear factor 1.

G. Crabtree, U. Francke, C. Kuo, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Andexanet Alfa for Acute Major Bleeding Associated with Factor Xa Inhibitors.

S. Connolly, B. Wiens, J. Eikelboom, 2016, The New England journal of medicine.

Using engineered 6-O-sulfotransferase to improve the synthesis of anticoagulant heparin.

Zhenqing Zhang, L. Pedersen, Yongmei Xu, 2020, Organic & biomolecular chemistry.

Reversal of Apixaban and Rivaroxaban Anticoagulation by Andexanet Alfa in ANNEXA-A and ANNEXA-R as Assessed by Non-Tissue Factor-Initiated Thrombin Generation Independent of Tissue Factor Pathway Inhibitor

P. Conley, J. Curnutte, G. Lu, 2018, EMJ Cardiology.

Evidence for Two Distinct G-protein-coupled ADP Receptors Mediating Platelet Activation

P. Conley, A. Tai, D. Vincent, 1999, Thrombosis and Haemostasis.

Identification of the platelet ADP receptor targeted by antithrombotic drugs

David Julius, Paquita Nurden, P. Nurden, 2001, Nature.

HNF-1 shares three sequence motifs with the POU domain proteins and is identical to LF-B1 and APF.

G. Crabtree, G. Courtois, C. Kuo, 1990, Genes & development.

A transcriptional hierarchy involved in mammalian cell-type specification

G. Crabtree, J. Darnell, F. Sladek, 1992, Nature.

Molecular bases of defective signal transduction in the platelet P2Y12 receptor of a patient with congenital bleeding

J. Ware, P. Conley, Z. Ruggeri, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Autocrine Purinergic Receptor Signaling Is Essential for Macrophage Chemotaxis

A. Schwab, T. Schwerdtle, P. Conley, 2010, Science Signaling.

Characterization of phycobiliprotein and linker polypeptide genes in Fremyella diplosiphon and their regulated expression during complementary chromatic adaptation

A. Grossman, P. Lemaux, P. Conley, 1988, Photosynthesis Research.

Full Study Report of Andexanet Alfa for Bleeding Associated with Factor Xa Inhibitors

A. Demchuk, S. Connolly, J. López-Sendón, 2019, The New England journal of medicine.

G-Protein–Coupled Receptors as Signaling Targets for Antiplatelet Therapy

S. Steinhubl, R. Becker, S. Goodman, 2009, Arteriosclerosis, thrombosis, and vascular biology.

Andexanet Alfa for the Reversal of Factor Xa Inhibitor Activity.

S. Connolly, B. Wiens, J. Leeds, 2015, The New England journal of medicine.

A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa

P. Conley, P. Luan, M. Karbarz, 2013, Nature Medicine.

Effect of Andexanet-TFPI Interaction on in Vitro Thrombin Formation and Coagulation Markers in the TF-Pathway

P. Conley, J. Curnutte, G. Lu, 2017 .

Platelet Endothelial Aggregation Receptor 1 (PEAR1), a Novel Epidermal Growth Factor Repeat-containing Transmembrane Receptor, Participates in Platelet Contact-induced Activation*

T. Quertermous, K. Clauser, L. Komuves, 2005, Journal of Biological Chemistry.

The Novel SYK/JAK Inhibitor Cerdulatinib Demonstrates Good Tolerability and Clinical Response in a Phase 2a Study in Relapsed/Refractory Peripheral T-Cell Lymphoma and Cutaneous T-Cell Lymphoma

Sonali M. Smith, S. Horwitz, T. Phillips, 2018, Blood.

Cerdulatinib, a novel dual SYK/JAK kinase inhibitor, has broad anti-tumor activity in both ABC and GCB types of diffuse large B cell lymphoma

G. Raca, P. Conley, A. Pandey, 2015, Oncotarget.

Effects of ibrutinib treatment on murine platelet function during inflammation and in primary hemostasis

P. Conley, W. Bergmeier, R. Lee, 2017, Haematologica.

Role of the P2Y12 Receptor in the Modulation of Murine Dendritic Cell Function by ADP

P. Conley, J. Boeynaems, B. Robaye, 2010, The Journal of Immunology.

A Phase 2 Study of the Dual SYK/JAK Inhibitor Cerdulatinib Demonstrates Good Tolerability and Clinical Response in Relapsed/Refractory Peripheral T-Cell Lymphoma and Cutaneous T-Cell Lymphoma

Sonali M. Smith, S. Horwitz, T. Phillips, 2019, Blood.

Rap1-Rac1 Circuits Potentiate Platelet Activation

M. Holinstat, P. Conley, W. Bergmeier, 2012, Arteriosclerosis, thrombosis, and vascular biology.

HNF-1 alpha and HNF-1 beta (vHNF-1) share dimerization and homeo domains, but not activation domains, and form heterodimers in vitro.

G. Crabtree, P. Conley, D. Mendel, 1991, Genes & development.

Thienopyridines, but Not Elinogrel, Result in Off-Target Effects at the Vessel Wall That Contribute to Bleeding

P. Conley, D. Phillips, A. Pandey, 2011, Journal of Pharmacology and Experimental Therapeutics.

The effect of elinogrel on high platelet reactivity during dual antiplatelet therapy and the relation to cyp 2c19*2 genotype: first experience in patients

A. Shuldiner, P. Gurbel, U. Tantry, 2010, Journal of thrombosis and haemostasis : JTH.

Immunolocalization of P2Y1 and TPα Receptors in Platelets Showed a Major Pool Associated with the Membranes of α-Granules and the Open Canalicular System

P. Nurden, P. Conley, A. Nurden, 2003 .

Molecular characterization and evolution of sequences encoding light-harvesting components in the chromatically adapting cyanobacterium Fremyella diplosiphon.

A. Grossman, P. Lemaux, P. Conley, 1988, Journal of molecular biology.

Hemostatic Efficacy and Anti-FXa (Factor Xa) Reversal With Andexanet Alfa in Intracranial Hemorrhage

A. Demchuk, S. Connolly, J. López-Sendón, 2021, Stroke.

Abstract 305: Cerdulatinib induces Bim expression and synergistic cell kill in combination with venetoclax in follicular lymphoma cell lines

J. Leeds, P. Conley, A. Pandey, 2018, Molecular and Cellular Biology / Genetics.

Agonist-induced calcium response in single human platelets assayed in a microfluidic device.

Kevin Munnelly, D. Cherbavaz, J. Farinas, 2005, Analytical biochemistry.

Efficacy and safety of the dual SYK/JAK inhibitor cerdulatinib in patients with relapsed or refractory B‐cell malignancies: Results of a phase I study

I. Flinn, J. Burger, J. Leeds, 2019, American journal of hematology.

Impaired activation of murine platelets lacking G alpha(i2).

P. Conley, R. Mortensen, H. Jantzen, 2001, The Journal of clinical investigation.

Andexanet Alfa for Specific Anticoagulation Reversal in Patients with Acute Bleeding during Treatment with Edoxaban

S. Connolly, J. Eikelboom, T. Milling, 2022, Thrombosis and Haemostasis.

A Clopidogrel-Insensitive Inducible Pool of P2Y12 Receptors Contributes to Thrombus Formation: Inhibition by Elinogrel, a Direct-Acting, Reversible P2Y12 Antagonist

P. Conley, D. Phillips, P. Andre, 2011, Journal of Pharmacology and Experimental Therapeutics.

Full Study Report of Andexanet Alfa for Bleeding Associated with Factor Xa Inhibitors

A. Demchuk, S. Connolly, J. López-Sendón, 2019, The New England journal of medicine.

The effect of elinogrel on high platelet reactivity during dual antiplatelet therapy and the relation to cyp 2c19*2 genotype: first experience in patients

A. Shuldiner, P. Gurbel, U. Tantry, 2010, Journal of thrombosis and haemostasis : JTH.

J. Wójcik, F. Neumann, R. Harrington, 2012, Circulation. Cardiovascular interventions.

INITIAL INTRAVENOUS EXPERIENCE WITH PRT060128 (PRT128), AN ORALLY-AVAILABLE, DIRECT-ACTING, AND REVERSIBLE P2Y12 INHIBITOR

P. Conley, D. Phillips, P. Leese, 2007 .

A Novel Pharmacodynamic Perfusion Chamber Assay Reveals Superior and Unique Antithrombotic Activities of a Direct-Acting P2Y12 Antagonist, PRT128, Relative to Clopidogrel.

A. Finn, H. Gold, P. Conley, 2006 .

Preclinical safety and efficacy of andexanet alfa in animal models

P. Conley, J. Curnutte, S. Hollenbach, 2017, Journal of thrombosis and haemostasis : JTH.