M. Ilies

发表

Tuning the self-assembling of pyridinium cationic lipids for efficient gene delivery into neuronal cells.

S. Savarala, E. Brǎiloiu, S. Wunder, 2013, Biomacromolecules.

Interfacial engineering of pyridinium gemini surfactants for the generation of synthetic transfection systems.

M. Ilies, V. D. Sharma, E. O. Aifuwa, 2013, Biomaterials.

Molecular and crystal structure of a self-assembling pyridinium cationic lipid

A. Balaban, T. Balaban, M. Ilies, 2010 .

Pyridinium cationic lipids in gene delivery: an in vitro and in vivo comparison of transfection efficiency versus a tetraalkylammonium congener.

A. Balaban, W. Seitz, M. Ilies, 2005, Archives of biochemistry and biophysics.

Solid-State Interactions at the Core-Coat Interface: Physicochemical Characterization of Enteric-Coated Omeprazole Pellets Without a Protective Sub-Coat

R. Fassihi, M. Ilies, V. D. Sharma, 2015, AAPS PharmSciTech.

Carbonic anhydrase inhibitors - Part 49: Synthesis of substituted ureido and thioureido derivatives of aromatic/heterocyclic sulfonamides with increased affinities for isozyme I

C. Supuran, A. Scozzafava, M. Ilies, 1998 .

Stabilization of soft lipid colloids: competing effects of nanoparticle decoration and supported lipid bilayer formation.

S. Savarala, S. Wunder, M. Ilies, 2011, ACS nano.

Interface-Engineered Amphiphilic Block Copolymers with Tuned Enzymatic Resistance for Controlled Delivery of Chemotherapeutic Drugs

M. Ilies, V. D. Sharma, Uttam Satyal, 2017 .

Carbonic Anhydrase Inhibitors. Part 49. Synthesis of Substituted Ureido and Thioureido Derivatives of Aromatic/Heterocyclic Sulfonamides with Increased Affinities for Isozyme I.

C. Supuran, A. Scozzafava, M. Ilies, 1998 .

Carbonic Anhydrase Inhibitors: Synthesis and Inhibition Against Isozymes I, II and IV of Topically Acting Antiglaucoma Sulfonamides Incorporating cis-5-Norbornene-endo-3-Carboxy-2-Carboxamido Moieties

C. Supuran, A. Casini, A. Scozzafava, 2001, Journal of enzyme inhibition.

Carbonic anhydrase inhibitors — Part 52. Metal complexes of heterocyclic sulfonamides: A new class of strong topical intraocular pressure-lowering agents in rabbits

C. Supuran, A. Scozzafava, M. Ilies, 1998 .

Modulation of pyridinium cationic lipid-DNA complex properties by pyridinium gemini surfactants and its impact on lipoplex transfection properties.

M. Madesh, E. Brǎiloiu, S. Wunder, 2014, Molecular pharmaceutics.

Palladium metal nanoparticle size control through ion paired structures of [PdCl4]2- with protonated PDMAEMA.

M. Ilies, B. Wayland, M. Fryd, 2012, Chemical communications.

Next-generation primary sulfonamide carbonic anhydrase inhibitors

M. Ilies, Suleyman Akocak, 2014 .

Pyridinium derivatives of histamine are potent activators of cytosolic carbonic anhydrase isoforms I, II and VII.

C. Supuran, A. Scozzafava, D. Vullo, 2011, Organic & biomolecular chemistry.

“FDA-approved carbonic anhydrase inhibitors reduce Amyloid β pathology and improve cognition, by ameliorating cerebrovascular health and glial fitness”

L. Østergaard, M. Ilies, E. Canepa, 2022, bioRxiv.

Synthesis and retrostructural analysis of libraries of AB3 and constitutional isomeric AB2 phenylpropyl ether-based supramolecular dendrimers.

V. Percec, E. Aqad, M. Sienkowska, 2006, Journal of the American Chemical Society.

Modifying the Hydrophilic–Hydrophobic Interface of PEG-b-PCL To Increase Micelle Stability: Preparation of PEG-b-PBO-b-PCL Triblock Copolymers, Micelle Formation, and Hydrolysis Kinetics

Xiao-bo Zhu, M. Ilies, B. Wayland, 2012 .

Carbonic Anhydrase Inhibitors: Synthesis of Sulfonamides Incorporating 2, 4, 6–Trisubstituted-Pyridinium-Ethylcarboxamido Moieties Possessing Membrane-Impermeability and in Vivo Selectivity for the Membrane-Bound (CA IV) Versus the Cytosolic (CA I and CA II) Isozymes

C. Supuran, A. Scozzafava, M. Ilies, 2000, Journal of enzyme inhibition.

Efficient and synergetic DNA delivery with pyridinium amphiphiles-gold nanoparticle composite systems having different packing parameters.

M. Ilies, Adrian Kizewski, 2016, Chemical communications.

Crystal Structure of Carbonic Anhydrase II in Complex with an Activating Ligand: Implications in Neuronal Function

C. Supuran, M. Ilies, R. McKenna, 2018, Molecular Neurobiology.

Lipid-based nucleic acid therapeutics with in vivo efficacy.

Md Abu Sufian, M. Ilies, Md. Abu Sufian, 2022, Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology.

Carbonic anhydrase inhibitors - Part 53. Synthesis of substituted-pyridinium derivatives of aromatic sulfonamides: The first non-polymeric membrane-impermeable inhibitors with selectivity for isozyme IV

C. Supuran, A. Scozzafava, M. Ilies, 1998 .

Carbonic anhydrase activators. Part 17. Synthesis and activation study of a series of 1-(1,2,4-triazole-(1H)-3-yl)-2,4,6-trisubstituted-pyridinium salts against isozymes I, II and IV

C. Supuran, A. Scozzafava, M. Ilies, 1997 .

Supersaturated controlled release matrix using amorphous dispersions of glipizide.

R. Fassihi, M. Ilies, Yonglai Yang, 2016, International journal of pharmaceutics.

Heterocyclic Cationic Gemini Surfactants: A Comparative Overview of Their Synthesis, Self‐assembling, Physicochemical, and Biological Properties

M. Ilies, V. D. Sharma, 2014, Medicinal research reviews.

Therapeutic applications of serine protease inhibitors

C. Supuran, A. Scozzafava, M. Ilies, 2002 .

Recent advances in the Nenitzescu indole synthesis (1990–2019)

M. Ilies, F. Dumitrascu, 2020 .

SYNTHESIS AND CARBONIC ANHYDRASE INHIBITORY ACTIVITY OF 5-BENZOYLAMIDO- AND 5-(3-NITROBENZOYLAMIDO)- 1,3,4-THIADIAZOLE-2-SULFONAMIDE AND THEIR METAL COMPLEXES

C. Supuran, A. Scozzafava, M. Ilies, 1997 .

Carbonic anhydrase inhibitors: aromatic and heterocyclic sulfonamides incorporating adamantyl moieties with strong anticonvulsant activity.

C. Supuran, A. Scozzafava, B. Masereel, 2004, Bioorganic & medicinal chemistry.

Carbonic anhydrase inhibitors — Part 29 1: Interaction of isozymes I, II and IV with benzolamide-like derivatives

C. Supuran, A. Scozzafava, M. Ilies, 1998 .

Lipophilic pyrylium salts in the synthesis of efficient pyridinium-based cationic lipids, gemini surfactants, and lipophilic oligomers for gene delivery.

A. Balaban, W. Seitz, M. Ilies, 2006, Journal of medicinal chemistry.

Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes.

C. Supuran, A. Scozzafava, M. Ilies, 2000, Journal of medicinal chemistry.

Carbonic Anhydrases as Potential Targets Against Neurovascular Unit Dysfunction in Alzheimer’s Disease and Stroke

M. Ilies, E. Canepa, S. Fossati, 2021, Frontiers in Aging Neuroscience.

Synthetic nucleic acid delivery systems: present and perspectives.

M. Ilies, B. Draghici, 2015, Journal of medicinal chemistry.

Choline Is an Intracellular Messenger Linking Extracellular Stimuli to IP3-Evoked Ca2+ Signals through Sigma-1 Receptors

Colin W. Taylor, E. Brǎiloiu, M. Ilies, 2019, Cell reports.

Choline Is an Intracellular Messenger Linking Extracellular Stimuli to IP3-Evoked Ca2+ Signals through Sigma-1 Receptors

Colin W. Taylor, E. Brǎiloiu, M. Ilies, 2019, Cell reports.

Pyridinium cationic lipids in gene delivery: a structure-activity correlation study.

A. Balaban, W. Seitz, I. Ghiviriga, 2004, Journal of medicinal chemistry.

Carbonic anhydrases as disease markers

A. Shabana, M. Ilies, U. Mondal, 2019, Expert opinion on therapeutic patents.

Pyridinium derivatives of 3-aminobenzenesulfonamide are nanomolar-potent inhibitors of tumor-expressed carbonic anhydrase isozymes CA IX and CA XII.

C. Supuran, M. Ilies, B. Iorga, 2020, Bioorganic chemistry.

Carbonic anhydrase activators: design of high affinity isozymes I, II, and IV activators, incorporating tri-/tetrasubstituted-pyridinium-azole moieties.

C. Supuran, A. Scozzafava, M. Ilies, 2002, Journal of medicinal chemistry.

Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects.

A Casini, C. Supuran, A. Casini, 2000, Journal of medicinal chemistry.

Carbonic anhydrase inhibitors for the treatment of tumors

J. Winum, M. Ilies, 2019, Carbonic Anhydrases.

Ethylene bis-imidazoles are highly potent and selective activators for isozymes VA and VII of carbonic anhydrase, with a potential nootropic effect.

C. Supuran, D. Vullo, M. Ilies, 2014, Chemical communications.

Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives.

Andrea Scozzafava, Daniela Vullo, Claudiu T Supuran, 2003, Journal of medicinal chemistry.

PEG Linker Length Strongly Affects Tumor Cell Killing by PEGylated Carbonic Anhydrase Inhibitors in Hypoxic Carcinomas Expressing Carbonic Anhydrase IX

C. Supuran, A. Shabana, M. Ilies, 2021, International journal of molecular sciences.

Structural Basis of Nanomolar Inhibition of Tumor-Associated Carbonic Anhydrase IX: X-Ray Crystallographic and Inhibition Study of Lipophilic Inhibitors with Acetazolamide Backbone.

C. Supuran, M. Ilies, A. Angeli, 2020, Journal of medicinal chemistry.

PEGylated Bis-Sulfonamide Carbonic Anhydrase Inhibitors Can Efficiently Control the Growth of Several Carbonic Anhydrase IX-Expressing Carcinomas.

C. Supuran, D. Vullo, E. Swenson, 2016, Journal of medicinal chemistry.

pH-Sensitive Multiligand Gold Nanoplatform Targeting Carbonic Anhydrase IX Enhances the Delivery of Doxorubicin to Hypoxic Tumor Spheroids and Overcomes the Hypoxia-Induced Chemoresistance.

C. Supuran, M. Madesh, A. Shabana, 2018, ACS applied materials & interfaces.

Efflux pumps, NHE1, monocarboxylate transporters, and ABC transporter subfamily inhibitors

M. Ilies, U. Mondal, 2021 .

Nonsulfonamide Carbonic Anhydrase Inhibitors

M. Ilies, M. Banciu, 2004 .

An inhibitor-like binding mode of a carbonic anhydrase activator within the active site of isoform II.

C. Supuran, A. Scozzafava, D. Vullo, 2011, Bioorganic & medicinal chemistry letters.

Protease Inhibitors: Part 4. Synthesis of Weakly Basic Thrombin Inhibitors Incorporating Pyridinium-Sulfanilylaminoguanidine Moieties

C. Supuran, M. Ilies, F. Briganti, 2000, Journal of enzyme inhibition.

Protease inhibitors: Part 12. Synthesis of potent matrix metalloproteinase and bacterial collagenase inhibitors incorporating sulfonylated N-4-nitrobenzyl-β-alanine hydroxamate moieties

C. Supuran, A. Scozzafava, M. Ilies, 2000 .

Synthetic Delivery Systems for DNA, siRNA, and mRNA Based on Pyridinium Amphiphiles

M. Ilies, V. D. Sharma, Uttam Satyal, 2017 .

Pyridinium Amphiphiles in Gene Delivery – Present and Perspectives

M. Ilies, V. D. Sharma, Li He, 2011 .

Recent developments in cationic lipid-mediated gene delivery and gene therapy

A. Balaban, M. Ilies, 2001 .

Expression Dynamics of CA IX Epitope in Cancer Cells under Intermittent Hypoxia Correlates with Extracellular pH Drop and Cell Killing by Ureido-Sulfonamide CA IX Inhibitors

C. Supuran, A. Shabana, M. Ilies, 2023, International journal of molecular sciences.

178. Structure-Activity Relationships in a Library of Pyridinium Non-Viral Vectors for Gene Delivery

A. Balaban, W. Seitz, M. Ilies, 2006 .

The Phospholipase A2 Superfamily: Structure, Isozymes, Catalysis, Physiologic and Pathologic Roles

M. Ilies, Shibbir Ahmed Khan, Shibbir Ahmed Khan, 2023, International journal of molecular sciences.

Evaluation of the Impact of Esterases and Lipases from the Circulatory System against Substrates of Different Lipophilicity

M. Ilies, L. Lam, 2022, International journal of molecular sciences.

Endothelial targeting of antibody-decorated polymeric filomicelles.

Silvia Muro, Dennis E Discher, Eric Simone, 2011, ACS nano.

Potential learning and memory disruptors and enhancers in a simple, 1-day operant task in mice

M. Ilies, E. Walker, R. K. Sanku, 2018, Behavioural pharmacology.

Formation and colloidal stability of DMPC supported lipid bilayers on SiO2 nanobeads.

S. Savarala, S. Wunder, M. Ilies, 2010, Langmuir : the ACS journal of surfaces and colloids.

Supported lipid bilayer nanosystems: stabilization by undulatory-protrusion forces and destabilization by lipid bridging.

S. Savarala, S. Wunder, M. Ilies, 2011, Langmuir : the ACS journal of surfaces and colloids.

Interfacially Engineered Pyridinium Pseudogemini Surfactants as Versatile and Efficient Supramolecular Delivery Systems for DNA, siRNA, and mRNA.

M. Madesh, E. Brǎiloiu, M. Ilies, 2017, ACS applied materials & interfaces.

Pyridinium‐Based Cationic Lipids as Gene‐Transfer Agents

A. Balaban, W. Seitz, M. Ilies, 2003 .

Cationic lipids in gene delivery: principles, vector design and therapeutical applications.

A. Balaban, W. Seitz, M. Ilies, 2002, Current pharmaceutical design.

Carbonic Anhydrase Inhibitors; Phosphoryl-Sulfonamides-A New Class of High Affinity Inhibitors of Isozymes I and II

C. Supuran, A. Scozzafava, M. Ilies, 2000, Journal of enzyme inhibition.

Protease inhibitors: synthesis of bacterial collagenase and matrix metalloproteinase inhibitors incorporating arylsulfonylureido and 5-dibenzo-suberenyl/suberyl moieties.

C. Supuran, A. Scozzafava, M. Ilies, 2003, Bioorganic & medicinal chemistry.

1,3,4-THIADIAZOLE DERIVATIVES. PART 8 : BINUCLEAR COMPLEXES OF CU(II), MN(II), CO(II), NI(II) AND ZN(II) WITH A SCHIFF BASE DERIVED FROM 5-AMINO-1,3,4 -THIADIAZOLE-2-SULFONAMIDE

C. Supuran, M. Ilies, M. Badea, 1997 .

Crystal Structure of Carbonic Anhydrase II in Complex with an Activating Ligand: Implications in Neuronal Function

C. Supuran, M. Ilies, R. McKenna, 2018, Molecular Neurobiology.

Efficient and Synergetic DNA Delivery with Pyridinium Amphiphiles—Gold Nanoparticle Composite Systems Having Different Packing Parameters

M. Ilies, Adrian Kizewski, 2016 .

Interfacial engineering of pyridinium gemini surfactants for the generation of synthetic transfection systems.

M. Ilies, V. D. Sharma, E. O. Aifuwa, 2013, Biomaterials.

Endothelial targeting of antibody-decorated polymeric filomicelles.

D. Discher, V. Muzykantov, S. Muro, 2011, ACS nano.

Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects.

Claudiu T. Supuran, Luca Menabuoni, Andrea Scozzafava, 2000, Journal of medicinal chemistry.

Control of Amphiphile Self-Assembling at the Molecular Level: Supra-Molecular Assemblies with Tuned Physicochemical Properties for Delivery Applications

M. Ilies, 2017 .