A. Dahan

A. Dahan, Avital Beig, R. Agbaria, 2015, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Predicting the solubility-permeability interplay when using cyclodextrins in solubility-enabling formulations: model validation.

A. Dahan, Jonathan M. Miller, 2012, International journal of pharmaceutics.

The biopharmaceutics of successful controlled release drug product: Segmental-dependent permeability of glipizide vs. metoprolol throughout the intestinal tract.

A. Dahan, R. Agbaria, Moran Zur, 2015, International journal of pharmaceutics.

Modern Prodrug Design for Targeted Oral Drug Delivery

S. Ben-Shabat, A. Dahan, E. Zimmermann, 2014, Molecules.

Cytomegalovirus Protease Targeted Prodrug Development

G. Amidon, Kyung-Dall Lee, A. Dahan, 2013, Molecular pharmaceutics.

Adequate Formulation Approach for Oral Chemotherapy: Etoposide Solubility, Permeability, and Overall Bioavailability from Cosolvent- vs. Vitamin E TPGS-Based Delivery Systems.

A. Dahan, Avital Beig, Noa Fine‐Shamir, 2021, International journal of pharmaceutics.

Antiviral effect of phytochemicals from medicinal plants: Applications and drug delivery strategies

S. Ben-Shabat, A. Dahan, Daniel Porat, 2019, Drug Delivery and Translational Research.

Concomitant solubility‐permeability increase: Vitamin E TPGS vs. amorphous solid dispersion as oral delivery systems for etoposide

A. Dahan, Avital Beig, Jonathan M. Miller, 2017, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Advantageous Solubility-Permeability Interplay When Using Amorphous Solid Dispersion (ASD) Formulation for the BCS Class IV P-gp Substrate Rifaximin: Simultaneous Increase of Both the Solubility and the Permeability

A. Dahan, Avital Beig, Jonathan M. Miller, 2017, The AAPS Journal.

Hydrotropic Solubilization of Lipophilic Drugs for Oral Delivery: The Effects of Urea and Nicotinamide on Carbamazepine Solubility–Permeability Interplay

A. Dahan, Avital Beig, R. Agbaria, 2016, Front. Pharmacol..

The solubility-permeability interplay and oral drug formulation design: Two heads are better than one.

A. Dahan, Avital Beig, Jonathan M. Miller, 2016, Advanced drug delivery reviews.

Head-To-Head Comparison of Different Solubility-Enabling Formulations of Etoposide and Their Consequent Solubility-Permeability Interplay.

A. Dahan, Avital Beig, R. Agbaria, 2015, Journal of pharmaceutical sciences.

The complexity of intestinal permeability: Assigning the correct BCS classification through careful data interpretation.

A. Dahan, Moran Zur, Allison S Hanson, 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

The low/high BCS permeability class boundary: physicochemical comparison of metoprolol and labetalol.

G. Amidon, Omri Wolk, A. Dahan, 2014, Molecular pharmaceutics.

The interaction of nifedipine with selected cyclodextrins and the subsequent solubility-permeability trade-off.

A. Dahan, Avital Beig, Jonathan M. Miller, 2013, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Oral Delivery of Lipophilic Drugs: The Tradeoff between Solubility Increase and Permeability Decrease When Using Cyclodextrin-Based Formulations

A. Dahan, Avital Beig, R. Agbaria, 2013, PloS one.

Regional-Dependent Intestinal Permeability and BCS Classification: Elucidation of pH-Related Complexity in Rats Using Pseudoephedrine

A. Dahan, Moran Fairstein, Rotem Swissa, 2013, The AAPS Journal.

A win-win solution in oral delivery of lipophilic drugs: supersaturation via amorphous solid dispersions increases apparent solubility without sacrifice of intestinal membrane permeability.

Arik Dahan, A. Dahan, Avital Beig, 2012, Molecular pharmaceutics.

Accounting for the solubility-permeability interplay in oral formulation development for poor water solubility drugs: the effect of PEG-400 on carbamazepine absorption.

A. Dahan, Avital Beig, Jonathan M. Miller, 2012, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

The solubility-permeability interplay when using cosolvents for solubilization: revising the way we use solubility-enabling formulations.

A. Dahan, G. Webster, Avital Beig, 2012, Molecular pharmaceutics.

The solubility-permeability interplay: mechanistic modeling and predictive application of the impact of micellar solubilization on intestinal permeation.

G. Amidon, G. Amidon, A. Dahan, 2011, Molecular pharmaceutics.

The solubility-permeability interplay in using cyclodextrins as pharmaceutical solubilizers: mechanistic modeling and application to progesterone.

Gordon L Amidon, Arik Dahan, G. Amidon, 2010, Journal of pharmaceutical sciences.

Prediction of Solubility and Permeability Class Membership: Provisional BCS Classification of the World’s Top Oral Drugs

Gordon L. Amidon, Arik Dahan, G. Amidon, 2009, The AAPS Journal.

Segmental-dependent membrane permeability along the intestine following oral drug administration: Evaluation of a triple single-pass intestinal perfusion (TSPIP) approach in the rat.

Brady T. West, G. Amidon, B. West, 2009, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Solubility, Permeability, and Their Interplay

A. Dahan, Avital Beig, Milica Markovic, 2018, Early Drug Development.

Candesartan Cilexetil In Vitro–In Vivo Correlation: Predictive Dissolution as a Development Tool

M. Bermejo, A. Dahan, A. García‐Arieta, 2020, Pharmaceutics.

Enhanced Gastrointestinal Absorption of Lipophilic Drugs

A. Hoffman, A. Dahan, 2006 .

Anticancer activity of Nigella sativa (black seed) and its relationship with the thermal processing and quinone composition of the seed

S. Ben-Shabat, A. Dahan, R. Agbaria, 2015, Drug design, development and therapy.

Quasi-equilibrium analysis of the ion-pair mediated membrane transport of low-permeability drugs.

G. Amidon, A. Dahan, Jonathan M. Miller, 2009, Journal of controlled release : official journal of the Controlled Release Society.

Antiviral effect of phytochemicals from medicinal plants: Applications and drug delivery strategies

S. Ben-Shabat, A. Dahan, Daniel Porat, 2019, Drug Delivery and Translational Research.

The Role of Paracellular Transport in the Intestinal Absorption and Biopharmaceutical Characterization of Minoxidil

G. Amidon, A. Dahan, S. Cvijić, 2022, Pharmaceutics.

The effect of different lipid based formulations on the oral absorption of lipophilic drugs: the ability of in vitro lipolysis and consecutive ex vivo intestinal permeability data to predict in vivo bioavailability in rats.

Arik Dahan, A. Hoffman, A. Dahan, 2007, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

The Solubility–Permeability Interplay and Its Implications in Formulation Design and Development for Poorly Soluble Drugs

A. Dahan, Jonathan M. Miller, 2012, The AAPS Journal.

Prodrugs for Improved Drug Delivery: Lessons Learned from Recently Developed and Marketed Products

S. Ben-Shabat, A. Dahan, Milica Markovic, 2020, Pharmaceutics.

High-permeability criterion for BCS classification: segmental/pH dependent permeability considerations.

Lawrence X. Yu, G. Amidon, H. Lennernäs, 2010, Molecular pharmaceutics.

Multiple Efflux Pumps Are Involved in the Transepithelial Transport of Colchicine: Combined Effect of P-Glycoprotein and Multidrug Resistance-Associated Protein 2 Leads to Decreased Intestinal Absorption Throughout the Entire Small Intestine

G. Amidon, A. Dahan, Hairat Sabit, 2009, Drug Metabolism and Disposition.

Grapefruit Juice and its Constituents Augment Colchicine Intestinal Absorption: Potential Hazardous Interaction and the Role of P-Glycoprotein

G. Amidon, A. Dahan, 2009, Pharmaceutical Research.

Dipeptidyl Peptidase IV as a Potential Target for Selective Prodrug Activation and Chemotherapeutic Action in Cancers

G. Amidon, Zhiqian Wu, Omri Wolk, 2014, Molecular pharmaceutics.

The oral absorption of phospholipid prodrugs: in vivo and in vitro mechanistic investigation of trafficking of a lecithin-valproic acid conjugate following oral administration.

Arik Dahan, A. Hoffman, A. Dahan, 2008, Journal of controlled release : official journal of the Controlled Release Society.

Lipidic prodrug approach for improved oral drug delivery and therapy

S. Ben-Shabat, A. Dahan, S. Keinan, 2018, Medicinal research reviews.

Purely in silico BCS classification: science based quality standards for the world's drugs.

G. Crippen, G. Amidon, C. Ramachandran, 2013, Molecular pharmaceutics.

Computational Simulations to Guide Enzyme-Mediated Prodrug Activation

S. Ben-Shabat, A. Dahan, Milica Markovic, 2020, International journal of molecular sciences.

Lipids and Lipid-Processing Pathways in Drug Delivery and Therapeutics

S. Ben-Shabat, A. Dahan, E. Zimmermann, 2020, International journal of molecular sciences.

Molecular Modeling-Guided Design of Phospholipid-Based Prodrugs

S. Ben-Shabat, A. Dahan, S. Keinan, 2019, International journal of molecular sciences.

Targeted prodrugs in oral drug delivery: the modern molecular biopharmaceutical approach

A. Dahan, R. Agbaria, R. Karaman, 2012, Expert opinion on drug delivery.

Biopharmaceutical characterization of rebamipide: the role of mucus binding in regional-dependent intestinal permeability.

A. Dahan, S. Cvijić, Milica Markovic, 2020, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Quantification of carbamazepine and its 10,11-epoxide metabolite in rat plasma by UPLC-UV and application to pharmacokinetic study.

A. Dahan, Avital Beig, 2014, Biomedical chromatography : BMC.

Prodrug-Based Targeting Approach for Inflammatory Bowel Diseases Therapy: Mechanistic Study of Phospholipid-Linker-Cyclosporine PLA2-Mediated Activation

Y. Miller, S. Ben-Shabat, A. Dahan, 2022, International journal of molecular sciences.

Increasing oral absorption of polar neuraminidase inhibitors: a prodrug transporter approach applied to oseltamivir analogue.

G. Amidon, Kyung-Dall Lee, A. Dahan, 2013, Molecular pharmaceutics.

Small intestinal efflux mediated by MRP2 and BCRP shifts sulfasalazine intestinal permeability from high to low, enabling its colonic targeting.

G. Amidon, A. Dahan, 2009, American journal of physiology. Gastrointestinal and liver physiology.

BCS Class IV Oral Drugs and Absorption Windows: Regional-Dependent Intestinal Permeability of Furosemide

A. Dahan, S. Cvijić, Milica Markovic, 2020, Pharmaceutics.

The Twofold Advantage of the Amorphous Form as an Oral Drug Delivery Practice for Lipophilic Compounds: Increased Apparent Solubility and Drug Flux Through the Intestinal Membrane

Viktoriya Ioffe-Dahan, A. Dahan, Avital Beig, 2013, The AAPS Journal.

Stomach pH before vs. after different bariatric surgery procedures: Clinical implications on drug delivery.

G. Shaked, D. Czeiger, O. Dukhno, 2021, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

The fraction dose absorbed, in humans, and high jejunal human permeability relationship.

G. Amidon, H. Lennernäs, A. Dahan, 2012, Molecular pharmaceutics.

Segmental-Dependent Drug Absorption and Delivery: The Intestinal Tract

Omri Wolk, A. Dahan, 2014 .

Transformation of dolutegravir into an ultra-long-acting parenteral prodrug formulation

H. Gendelman, J. McMillan, A. Dahan, 2022, Nature Communications.

Phospholipid‐drug conjugates as a novel oral drug targeting approach for the treatment of inflammatory bowel disease

Svetlana Epstein, S. Ben-Shabat, A. Dahan, 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Oral levothyroxine therapy postbariatric surgery: Biopharmaceutical aspects and clinical effects.

A. Dahan, Carmil Azran, Daniel Porat, 2019, Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery.

Investigating drug absorption from the colon: Single-pass vs. Doluisio approaches to in-situ rat large-intestinal perfusion.

M. Bermejo, A. Dahan, I. González-Álvarez, 2017, International journal of pharmaceutics.

DP-155, a lecithin derivative of indomethacin, is a novel nonsteroidal antiinflammatory drug for analgesia and Alzheimer's disease therapy.

A. Hoffman, A. Dahan, D. Simmons, 2007, CNS drug reviews.

Enabling the intestinal absorption of highly polar antiviral agents: ion-pair facilitated membrane permeation of zanamivir heptyl ester and guanidino oseltamivir.

G. Amidon, A. Dahan, Jonathan M. Miller, 2010, Molecular pharmaceutics.

Lamotrigine therapy in patients after bariatric surgery: Potentially hampered solubility and dissolution.

O. Dukhno, A. Dahan, E. Vainer, 2021, International journal of pharmaceutics.

Carbamazepine Therapy After Bariatric Surgery: Eight Sleeve Gastrectomy Cases and Review of the Literature

A. Dahan, Daniel Porat, O. Lavon, 2022, Obesity Surgery.

Oral drug therapy following bariatric surgery: an overview of fundamentals, literature and clinical recommendations

G. Shaked, D. Czeiger, Omri Wolk, 2016, Obesity reviews : an official journal of the International Association for the Study of Obesity.

Computational modeling and in-vitro/in-silico correlation of phospholipid-based prodrugs for targeted drug delivery in inflammatory bowel disease

Igor Kurnikov, Shahar Keinan, Milica Markovic, 2017, Journal of Computer-Aided Molecular Design.

Lithium Toxicity with Severe Bradycardia Post Sleeve Gastrectomy: a Case Report and Review of the Literature

A. Dahan, N. Sakran, Carmil Azran, 2018, Obesity Surgery.

Gastrointestinal Dissolution and Absorption of Class II Drugs

G. Amidon, A. Dahan, 2008 .

Segmental-Dependent Solubility and Permeability as Key Factors Guiding Controlled Release Drug Product Development

A. Dahan, I. González-Álvarez, Milica Markovic, 2020, Pharmaceutics.

A novel mechanism for oral controlled release of drugs by continuous degradation of a phospholipid prodrug along the intestine: in-vivo and in-vitro evaluation of an indomethacin-lecithin conjugate.

A. Hoffman, A. Dahan, R. Duvdevani, 2007, Journal of controlled release : official journal of the Controlled Release Society.

Oral Bioavailability of Peptide and Peptidomimetic Drugs

G. Amidon, A. Dahan, Y. Tsume, 2011 .

The effect of general anesthesia on the intestinal lymphatic transport of lipophilic drugs: comparison between anesthetized and freely moving conscious rat models.

A. Hoffman, A. Dahan, N. Ezov, 2007, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Therapeutic Potential of Phytocannabinoid Cannabigerol for Multiple Sclerosis: Modulation of Microglial Activation In Vitro and In Vivo

S. Ben-Shabat, A. Dahan, Leenor Alfahel, 2023, Biomolecules.

Provisional BCS Classification of the Leading Oral Drugs on the Global Market

G. Amidon, A. Dahan, 2010, Burger's Medicinal Chemistry and Drug Discovery.

Transcriptomic analyses reveal the molecular mechanisms of schisandrin B alleviates CCl4-induced liver fibrosis in rats by RNA-sequencing.

A. Dahan, Guoqing Zhang, Hai Zhang, 2019, Chemico-biological interactions.

Regional-Dependent Intestinal Permeability and BCS Classification: Elucidation of pH-Related Complexity in Rats Using Pseudoephedrine

A. Dahan, Moran Fairstein, Rotem Swissa, 2013, The AAPS Journal.

Biowaiver monographs for immediate-release solid oral dosage forms: codeine phosphate.

J. Polli, G. Amidon, V. Shah, 2014, Journal of pharmaceutical sciences.

The H2 Receptor Antagonist Nizatidine is a P-Glycoprotein Substrate: Characterization of its Intestinal Epithelial Cell Efflux Transport

G. Amidon, A. Dahan, Hairat Sabit, 2009, The AAPS Journal.

Provisional in-silico biopharmaceutics classification (BCS) to guide oral drug product development

Arik Dahan, Omri Wolk, A. Dahan, 2014, Drug design, development and therapy.

Provisional in-silico biopharmaceutics classification (BCS) to guide oral drug product development

Omri Wolk, A. Dahan, R. Agbaria, 2014 .

Provisional in-silico biopharmaceutics classification (BCS) to guide oral drug product development

Omri Wolk, A. Dahan, R. Agbaria, 2014 .

Provisional in-silico biopharmaceutics classification (BCS) to guide oral drug product development

Omri Wolk, A. Dahan, R. Agbaria, 2014 .

Influence of Bariatric Surgery on Levetiracetam Clinical Effectiveness: Case Series

A. Dahan, Daniel Porat, O. Lavon, 2022, Obesity Surgery.

Severe hypertriglyceridemia and colchicine intoxication following suicide attempt

A. Dahan, S. Lev, D. Snyder, 2017, Drug design, development and therapy.

A Novel Phospholipid Derivative of Indomethacin, DP-155 [Mixture of 1-Steroyl and 1-Palmitoyl-2-{6-[1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolyl acetamido]hexanoyl}-sn-glycero-3-phosophatidyl Choline], Shows Superior Safety and Similar Efficacy in Reducing Brain Amyloid β in an Alzheimer's Disea

J. Koh, A. Hoffman, A. Dahan, 2006, Journal of Pharmacology and Experimental Therapeutics.

Pathways for Dolutegravir Transformation from a Daily Oral to a Once-a-Year Parenteral Medicine

H. Gendelman, J. McMillan, A. Dahan, 2022 .

MRP2 mediated drug-drug interaction: indomethacin increases sulfasalazine absorption in the small intestine, potentially decreasing its colonic targeting.

G. Amidon, A. Dahan, 2010, International journal of pharmaceutics.

A win-win solution in oral delivery of lipophilic drugs: supersaturation via amorphous solid dispersions increases apparent solubility without sacrifice of intestinal membrane permeability.

A. Dahan, Avital Beig, Jonathan M. Miller, 2012, Molecular pharmaceutics.

New targeting strategies in drug therapy of inflammatory bowel disease: mechanistic approaches and opportunities

Omri Wolk, Svetlana Epstein, Viktoriya Ioffe-Dahan, 2013, Expert opinion on drug delivery.

Revealing Synergistic Mechanism of Multiple Components in Gandi Capsule for Diabetic Nephropathy Therapeutics by Network Pharmacology

A. Dahan, Y. Chai, Xiaofei Chen, 2018, Evidence-based complementary and alternative medicine : eCAM.

An Emerging Strategy for Neuroinflammation Treatment: Combined Cannabidiol and Angiotensin Receptor Blockers Treatments Effectively Inhibit Glial Nitric Oxide Release

S. Ben-Shabat, A. Dahan, F. Baratta, 2023, International journal of molecular sciences.

Solubility-enabling formulations for oral delivery of lipophilic drugs: considering the solubility-permeability interplay for accelerated formulation development.

A. Dahan, Noa Fine‐Shamir, 2023, Expert opinion on drug delivery.

Segmental dependent transport of low permeability compounds along the small intestine due to P-glycoprotein: the role of efflux transport in the oral absorption of BCS class III drugs.

G. Amidon, A. Dahan, 2009, Molecular Pharmaceutics.

The complexity of intestinal permeability: Assigning the correct BCS classification through careful data interpretation.

A. Dahan, Moran Zur, Allison S Hanson, 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Correction: Oral Delivery of Lipophilic Drugs: The Tradeoff between Solubility Increase and Permeability Decrease When Using Cyclodextrin-Based Formulations

A. Dahan, Avital Beig, R. Agbaria, 2013, PLoS ONE.

A novel phospholipid derivative of indomethacin, DP-155 [mixture of 1-steroyl and 1-palmitoyl-2-{6-[1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolyl acetamido]hexanoyl}-sn-glycero-3-phosophatidyl [corrected] choline], shows superior safety and similar efficacy in reducing brain amyloid beta in an Al

J. Koh, A. Hoffman, A. Dahan, 2006, The Journal of pharmacology and experimental therapeutics.

The Complexity of Bariatric Patient’s Pharmacotherapy: Sildenafil Biopharmaceutics and Pharmacokinetics before vs. after Gastric Sleeve/Bypass

O. Dukhno, A. Dahan, S. Cvijić, 2023, Pharmaceutics.

Towards Effective Antiviral Oral Therapy: Development of a Novel Self-Double Emulsifying Drug Delivery System for Improved Zanamivir Intestinal Permeability

A. Dahan, Nir Debotton, Sapir Ifrah, 2023, Pharmaceutics.