J. Linden

B. Lanpher, C. Tribble, J. Linden, 1999, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Characterization of [125I]ZM 241385 binding to adenosine A2A receptors in the pineal of sheep brain

T. F. Murray, J. Linden, L. Kruger, 2006, Brain Research.

Characterization of two affinity states of adenosine A2a receptors with a new radioligand, 2-[2-(4-amino-3-[125I]iodophenyl)ethylamino]adenosine.

J. Linden, D. Luthin, D. Sawmiller, 1995, Molecular pharmacology.

Comparison of A4 and A2a binding sites in striatum and COS cells transfected with adenosine A2a receptors.

J. Linden, D. Luthin, 1995, The Journal of pharmacology and experimental therapeutics.

Early adenosine receptor activation ameliorates spinal cord reperfusion injury

D. Okonkwo, C. Tribble, J. Linden, 2008, Journal of cardiovascular medicine.

Attenuation of Spinal Cord Injury After Thoracic Aortic Cross-Clamping Agonist for 2A Comparison of Systemic and Retrograde Delivery of Adenosine A

D. Okonkwo, J. Linden, I. Kron, 2013 .

Comparison of Systemic and Retrograde Delivery of Adenosine A 2A Agonist for Attenuation of Spinal Cord Injury After Thoracic Aortic

D. Okonkwo, C. Tribble, J. Linden, 2006 .

Functional and cytoarchitectural spinal cord protection by ATL-146e after ischemia/reperfusion is mediated by adenosine receptor agonism.

D. Okonkwo, C. Tribble, J. Linden, 2006, Journal of vascular surgery.

Comparison of systemic and retrograde delivery of adenosine A2A agonist for attenuation of spinal cord injury after thoracic aortic cross-clamping.

D. Okonkwo, C. Tribble, J. Linden, 2006, The Annals of thoracic surgery.

Systemic adenosine A2A agonist ameliorates ischemic reperfusion injury in the rabbit spinal cord.

C. Tribble, J. Linden, J. Rieger, 2001, Annals of Thoracic Surgery.

Myeloid expression of adenosine A2A receptor suppresses T and NK cell responses in the solid tumor microenvironment.

J. Linden, Y. Day, Caglar Cekic, 2014, Cancer research.

Adenosine A2A analogue reduces long-term neurologic injury after blunt spinal trauma.

D. Okonkwo, C. Tribble, J. Linden, 2004, The Journal of surgical research.

Induction of antiinflammatory purinergic signaling in activated human iNKT cells.

J. Linden, Gene Lin, Jennifer C. Yu, 2018, JCI insight.

Phorbol esters enhance the cyclic GMP response of T84 cells to the heat-stable enterotoxin of Escherichia coli (STa)

E. Hewlett, J. Linden, J. Crane, 1990, Infection and immunity.

A Novel Neutrophil-Specific PET Imaging Agent: cFLFLFK-PEG-64Cu

B. Kundu, Li Xiao, Yi Zhang, 2009, Journal of Nuclear Medicine.

Microenvironment and Immunology MyeloidExpressionofAdenosineA 2 AReceptor SuppressesT andNKCell Responses in the Solid TumorMicroenvironment

J. Linden, Y. Day, Caglar Cekic, 2014 .

Adenosine Promotes Tumor Metastasis

J. Linden, 2013, Science Signaling.

NKT cells mediate pulmonary inflammation and dysfunction in murine sickle cell disease through production of IFN-gamma and CXCR3 chemokines.

R. Strieter, J. Linden, J. Lannigan, 2009, Blood.

Feeding desensitizes A1 adenosine receptors in adipose through FOXO1-mediated transcriptional regulation

T. Harris, M. E. Granade, J. Linden, 2022, bioRxiv.

Hemodynamic and metabolic correlates of dipyridamole-induced myocardial thallium-201 perfusion abnormalities in multivessel coronary artery disease.

G. Beller, D. Watson, M. Feldman, 1994, The American journal of cardiology.

Purification of A1 adenosine receptor-G-protein complexes: effects of receptor down-regulation and phosphorylation on coupling.

J. Linden, A. Robeva, Z. Gao, 1999, The Biochemical journal.

Evidence for regulated coupling of A1 adenosine receptors by phosphorylation in Zucker rats.

S. Vannucci, J. Linden, R. Woodard, 1995, The American journal of physiology.

Enhanced Sensitivity of Heart Cells to Adenosine and Up-Regulation of Receptor Number After Treatment of Guinea Pigs With Theophylline

Sheng-Nan Wu, J. Linden, L. Belardinelli, 1989, Circulation research.

Dual acting antioxidant A1 adenosine receptor agonists.

Shane M. Devine, P. White, S. Bottle, 2007, Bioorganic & medicinal chemistry letters.

The precise radioimmunoassay of adenosine: minimization of sample collection artifacts and immunocrossreactivity.

M. Feldman, C. Ayers, J. Linden, 1992, Analytical biochemistry.

Myocardial Infarct–Sparing Effect of Adenosine A2A Receptor Activation Is due to Its Action on CD4+ T Lymphocytes

Yaqin Xu, B. A. French, J. Linden, 2006, Circulation.

Activation of Adenosine 2A Receptors Attenuates Allograft Rejection and Alloantigen Recognition1

Liping Huang, J. Linden, M. Okusa, 2007, The Journal of Immunology.

Adenosine A2A receptor activation reduces inflammation and preserves pulmonary function in an in vivo model of lung transplantation.

C. Tribble, J. Linden, R. Legallo, 2005, The Journal of thoracic and cardiovascular surgery.

secretion by rat atria superfused in vitro The influence of resting tension on immunoreactive atrial natriuretic peptide

J. Linden, R. Schiebinger, 2011 .

Genoprotective pathways. II. Attenuation of oxidative DNA damage by isopentenyl diphosphate.

J. Linden, J. Holoshitz, Song Ling, 2004, Mutation research.

Allosteric enhancers of A1 adenosine receptors increase receptor-G protein coupling and counteract Guanine nucleotide effects on agonist binding.

J. Linden, R. Olsson, H. Figler, 2003, Molecular pharmacology.

The allosteric enhancer, PD 81,723, stabilizes human A1 adenosine receptor coupling to G proteins.

J. Linden, S. Bhattacharya, 1995, Biochimica et biophysica acta.

Adenosine Stimulates Human Sperm Motility via A2 Receptors

J. Linden, S. -. Wu, P. Chiang, 1993, The Journal of pharmacy and pharmacology.

IDENTIFICATION OF ADENOSINE RECEPTORS IN HUMAN SPERMATOZOA

J. Linden, S. -. Wu, M. Shen, 1993, Clinical and experimental pharmacology & physiology.

Xenopus oocyte K+ current. I. FSH and adenosine stimulate follicle cell-dependent currents.

J. T. Hackett, L. Greenfield, J. Linden, 1990, The American journal of physiology.

Xenopus oocyte K+ current. II. Adenylyl cyclase-linked receptors on follicle cells.

J. T. Hackett, L. Greenfield, J. Linden, 1990, The American journal of physiology.

Developmentally distinct CD4+ Treg lineages shape the CD8+ T cell response to acute Listeria infection

J. Greenbaum, J. Linden, Ashu Chawla, 2022, Proceedings of the National Academy of Sciences of the United States of America.

The Cholesterol Transporter ABCG1 Links Cholesterol Homeostasis and Tumor Immunity

C. Hedrick, J. Linden, Duygu Sag, 2015, Nature Communications.

Blood Flow Regulation in Inflammation

J. Linden, 2001 .

Lidocaine Enhances G&agr;i Protein Function

J. Linden, M. Hollmann, M. Durieux, 2003 .

Lidocaine Enhances G (cid:1) i Protein Function

J. Linden, M. Hollmann, M. Durieux, 2003 .

Adenosine A2A receptor activation decreases reperfusion injury associated with high-flow reperfusion.

C. Tribble, J. Linden, J. Rieger, 2002, The Journal of thoracic and cardiovascular surgery.

Cyclic AMP-dependent inhibition of human neutrophil oxidative activity by substituted 2-propynylcyclohexyl adenosine A(2A) receptor agonists.

J. Linden, J. Rieger, T. Macdonald, 2001, British journal of pharmacology.

Adenosine A2A receptor activation reduces infarct size in the isolated, perfused mouse heart by inhibiting resident cardiac mast cell degranulation.

J. Linden, Kori L Wallace, Melissa A. Marshall, 2008, American journal of physiology. Heart and circulatory physiology.

Adenosine A2A receptor activation reduces infarct size in the isolated, perfused mouse heart by inhibiting resident cardiac mast cell degranulation.

J. Linden, Kori L Wallace, Melissa A. Marshall, 2008, American journal of physiology. Heart and circulatory physiology.

Effect of atrial contraction frequency on atrial natriuretic peptide secretion.

J. Linden, R. Schiebinger, 1986, The American journal of physiology.

Pharmacology of 2‐cyclohexylmethylidenehydrazinoadenosine (WRC‐0470), a novel, short‐acting adenosine A2A receptor agonist that produces selective coronary vasodilation

J. Linden, Robert Barrett, W. Abraham, 1997 .

The evolution of ischemic spinal cord injury in function, cytoarchitecture, and inflammation and the effects of adenosine A2A receptor activation.

D. Okonkwo, C. Tribble, J. Linden, 2004, The Journal of thoracic and cardiovascular surgery.

Adenosine signaling via the adenosine 2B receptor is involved in bronchiolitis obliterans development.

G. Ailawadi, J. Linden, I. Kron, 2010, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Interrelationship of atrial natriuretic peptide, atrial volume, and renal function in premature infants.

J. Kattwinkel, W. Teague, R. Carey, 1990, The Journal of pediatrics.

Influence of propranolol, enalaprilat, verapamil, and caffeine on adenosine A(2A)-receptor-mediated coronary vasodilation.

G. Beller, M. Ruiz, D. Watson, 2002, Journal of the American College of Cardiology.

Inhibiting CXCL12 blocks fibrocyte migration and differentiation and attenuates bronchiolitis obliterans in a murine heterotopic tracheal transplant model.

M. Stoler, J. Linden, I. Kron, 2013, The Journal of thoracic and cardiovascular surgery.

Endothelium-Dependent Relaxation and Cyclic GMP Accumulation in Rabbit Pulmonary Artery Are Selectively Impaired by Moderate Hypoxia

R. Johns, M. Peach, J. Linden, 1989, Circulation research.

A2A Adenosine Receptor Agonist and PDE4 Inhibition Delays Inflammation but Fails to Reduce Injury in Experimental Obstructive Nephropathy

B. Thornhill, R. Chevalier, J. Linden, 2005, Nephron Experimental Nephrology.

Adenosine A2A receptor activation attenuates inflammation and injury in diabetic nephropathy.

Liping Huang, H. Ye, J. Linden, 2006, American journal of physiology. Renal physiology.

An A2A adenosine receptor agonist, ATL313, reduces inflammation and improves survival in murine sepsis models

J. Linden, T. Obrig, W. Scheld, 2008, BMC infectious diseases.

Assessment of Myocardial Inflammation Produced by Experimental Coronary Occlusion and Reperfusion With 99mTc-RP517, a New Leukotriene B4 Receptor Antagonist That Preferentially Labels Neutrophils In Vivo

G. Beller, M. Ruiz, D. Glover, 2002, Circulation.

2-Amino-3-aroyl-4,5-alkylthiophenes: agonist allosteric enhancers at human A(1) adenosine receptors.

J. Linden, P. Scammells, B. Giunta, 2002, Journal of medicinal chemistry.

The Role of Fibrocytes in Sickle Cell Lung Disease

M. DeBaun, M. Burdick, R. Strieter, 2012, PloS one.

Adenosine A2A activation attenuates nontransplantation lung reperfusion injury.

Ramesh Singh, C. Tribble, J. Linden, 2008, The Journal of surgical research.

Activation of Adenosine 2A Receptors Attenuates Allograft Rejection and Alloantigen Recognition1

Liping Huang, J. Linden, M. Okusa, 2007, The Journal of Immunology.

Activation of A2A adenosine receptors inhibits expression of alpha 4/beta 1 integrin (very late antigen-4) on stimulated human neutrophils.

M. Lawrence, J. Linden, C. Lappas, 2004, Journal of leukocyte biology.

VIP elevates platelet cyclic AMP (cAMP) levels and inhibits in vitro platelet activation induced by platelet-activating factor (PAF)

S. Said, J. Linden, C. P. Cox, 1984, Peptides.

Activation of A1, A2A, or A3 adenosine receptors attenuates lung ischemia-reperfusion injury.

J. Linden, I. Kron, V. Laubach, 2010, The Journal of thoracic and cardiovascular surgery.

Role of A2A adenosine receptors in inflammation

J. Linden, G. Sullivan, 1998 .

Extracellular adenosine regulates colitis through effects on lymphoid and nonlymphoid cells.

C. Ware, S. Feldman, J. Linden, 2014, American journal of physiology. Gastrointestinal and liver physiology.

Adenosine A2A receptor agonist (regadenoson) in human lung transplantation.

M. Conaway, A. S. Krupnick, G. Petroni, 2020, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Adenosine influences myeloid cells to inhibit aeroallergen sensitization.

J. Linden, H. Pei, 2016, American journal of physiology. Lung cellular and molecular physiology.

The role of adenosine A2A receptor signaling in bronchiolitis obliterans.

M. Stoler, G. Ailawadi, J. Linden, 2009, The Annals of thoracic surgery.

Selective adenosine-A2A activation reduces lung reperfusion injury following transplantation.

B. Lanpher, C. Tribble, J. Linden, 1999, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Adenosine-Mediated Cardioprotection in Ischemic-Reperfused Mouse Heart

J. Linden, J. Peart, J. Headrick, 2002, Journal of cardiovascular pharmacology.

Leukocyte compartments in the mouse lung: distinguishing between marginated, interstitial, and alveolar cells in response to injury.

J. Linden, B. Mehrad, Kori L Wallace, 2012, Journal of immunological methods.

Cloned adenosine A3 receptors: pharmacological properties, species differences and receptor functions.

J. Linden, 1994, Trends in pharmacological sciences.

N6-ethyl-2-alkynyl NECAs, selective human A3 adenosine receptor agonists.

J. Linden, T. Macdonald, Ran Zhu, 2006, Bioorganic & medicinal chemistry letters.

Targeted deletion of A(3) adenosine receptors improves tolerance to ischemia-reperfusion injury in mouse myocardium.

Z. Yang, J. Linden, M. Jacobson, 2001, American journal of physiology. Heart and circulatory physiology.

Selective A 2A adenosine receptor activation reduces ischemia-reperfusion injury in rat kidney reduces

Liping Huang, J. Linden, M. Okusa, 1999 .

Molecular Biology and Pharmacology of Recombinant Adenosine Receptors

K. Jacobson, J. Linden, 1998 .

Molecular cloning of adenosine A1 and A2 receptors.

A. Tucker, J. Linden, K. Lynch, 1991, Trends in pharmacological sciences.

125I-labeled 8-phenylxanthine derivatives: antagonist radioligands for adenosine A1 receptors.

J. Linden, Charles Earl, A. Patel, 1988, Journal of medicinal chemistry.

The infarct-sparing effect of IB-MECA against myocardial ischemia/reperfusion injury in mice is mediated by sequential activation of adenosine A3 and A2A receptors

B. A. French, J. Linden, Zequan Yang, 2015, Basic Research in Cardiology.

The influence of resting tension on immunoreactive atrial natriuretic peptide secretion by rat atria superfused in vitro.

J. Linden, R. Schiebinger, J. Rick, 1986, Circulation research.

Atorvastatin at Reperfusion Reduces Myocardial Infarct Size in Mice by Activating eNOS in Bone Marrow-Derived Cells

B. A. French, J. Linden, Zequan Yang, 2014, PloS one.

Renal Effects of Atrial Natriuretic Peptide Infusion in Young and Adult Rats

R. Carey, M. Peach, B. Thornhill, 1988, Pediatric Research.

Adenosine A₂A agonist improves lung function during ex vivo lung perfusion.

J. Linden, I. Kron, V. Laubach, 2011, The Annals of thoracic surgery.

Biochemical mechanisms for the inotropic effect of the cardiotonic drug milrinone.

J. Linden, W. Weglicki, Charles Earl, 1986, Journal of cardiovascular pharmacology.

Clearance of Apoptotic cells by Lung Alveolar Macrophages Prevents Development of House Dust Mite-induced Asthmatic Lung Inflammation.

M. Croft, J. Linden, H. Pei, 2020, The Journal of allergy and clinical immunology.

Effects of long-term treatment with the allosteric enhancer, PD81,723, on Chinese hamster ovary cells expressing recombinant human A1 adenosine receptors.

J. Linden, S. Bhattacharya, 1996, Molecular pharmacology.

Allosteric enhancer PD 81,723 acts by novel mechanism to potentiate cardiac actions of adenosine.

D. Dennis, J. Linden, L. Belardinelli, 1994, Circulation research.

Human A(2A) adenosine receptors: high-affinity agonist binding to receptor-G protein complexes containing Gbeta(4).

J. Linden, J. Rieger, T. Macdonald, 2002, Molecular pharmacology.

Indirect effect of guanine nucleotides on antagonist binding to A1 adenosine receptors: occupation of cryptic binding sites by endogenous vesicular adenosine.

J. Linden, H. Taylor, M. R. Prater, 1992, Molecular pharmacology.

Enhanced cAMP accumulation after termination of cholinergic action in the heart

J. Linden, 1987, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Cell IL-6 Differentiation via Stimulation of Dendritic Adenosine Receptor Promotes Th17 2B The A

Jeffrey M. Wilson, J. Linden, W. Ross, 2011 .

Research : Focus on Platelets P-Selectin – Mediated Platelet-Neutrophil Aggregate Formation Activates Neutrophils in Mouse and Human Sickle Cell Disease *

R. Polanowska-Grabowska, J. Linden, Kori L Wallace, 2010 .

Adenosine A2A receptor activation reduces recurrence and mortality from Clostridium difficile infection in mice following vancomycin treatment

R. Guerrant, J. Linden, J. Rieger, 2012, BMC Infectious Diseases.

New potent and selective A1 adenosine receptor agonists.

S. A. Hutchinson, J. Linden, P. Scammells, 2004, Bioorganic & medicinal chemistry.

myocardium. Correlation with cyclic adenosine monophosphate and receptor densities. The mechanism by which adenosine and cholinergic agents reduce contractility in rat

J. Linden, A. Patel, C. Hollen, 2013 .

adenosine receptors in heart (125I)Aminobenzyladenosine, a new radioligand with improved specific binding to

J. Linden, S. Sadek, A. Patel, 2011 .

The Mechanism by Which Adenosine and Cholinergic Agents Reduce Contractility in Rat Myocardium: Correlation with Cyclic Adenosine Monophosphate and Receptor Densities

J. Linden, A. Patel, C. Hollen, 1985, Circulation research.

[125I]Aminobenzyladenosine, a new radioligand with improved specific binding to adenosine receptors in heart.

J. Linden, S. Sadek, A. Patel, 1985, Circulation research.

The role of adenosine signaling in sickle cell therapeutics.

J. Linden, D. Nathan, Joshua J Field, 2014, Hematology/oncology clinics of North America.

Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions.

K. Jacobson, C. Müller, J. Linden, 2002, Journal of medicinal chemistry.

Comparison of spectrophotometric and biological assays for nitric oxide (NO) and endothelium-derived relaxing factor (EDRF): nonspecificity of the diazotization reaction for NO and failure to detect EDRF.

R. Johns, M. Peach, J. Linden, 1990, The Journal of pharmacology and experimental therapeutics.

Statins Counter the Effects of Hyperlipidemia on iNKT Cells

J. Linden, 2012, Cardiovascular Drugs and Therapy.

Pharmacological Stress Myocardial Perfusion Imaging With the Potent and Selective A2A Adenosine Receptor Agonists ATL193 and ATL146e Administered by Either Intravenous Infusion or Bolus Injection

G. Beller, M. Ruiz, D. Watson, 2001, Circulation.

Extracellular Action of Adenosine and the Antagonism by Aminophylline on the Atrioventricular Conduction of Isolated Perfused Guinea Pig and Rat Hearts

R. Berne, J. Linden, L. Belardinelli, 1982, Circulation research.

receptor-mediated tissue protection: role of macrophages Renal ischemia-reperfusion injury and adenosine 2A

Liping Huang, J. Linden, M. Okusa, 2016 .

NGmMonomethyl L-Arginine Inhibits Endothelium-Derived Relaxing Factor-Stimulated Cyclic GMP Accumulation in Cocultures of Endothelial and Vascular Smooth Muscle Cells

R. Johns, M. Peach, J. Linden, 2005 .

Targeting iNKT cells for the treatment of sickle cell disease.

J. Linden, D. Nathan, Joshua J Field, 2011, Clinical immunology.

A selective adenosine A2A receptor agonist, ATL-146e, prevents concanavalin A-induced acute liver injury in mice.

Sumio Watanabe, M. Otaka, M. Odashima, 2006, Biochemical and biophysical research communications.

Activation of Adenosine 2 A Receptors Attenuates Allograft Rejection and Alloantigen Recognition 1

Liping Huang, J. Linden, M. Okusa, 2007 .

A1-receptor blockade: a novel approach for assessing myocardial viability in chronic ischemic cardiomyopathy.

S. Kaul, J. Linden, H. Leong-Poi, 2003, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

Compartmentalization of neutrophils in the kidney and lung following acute ischemic kidney injury.

J. Reutershan, Liping Huang, H. Cathro, 2009, Kidney international.

Modulation of guanylate cyclase by lipoxygenase inhibitors.

J. Linden, D. Clark, 1986, Hypertension.

Adenosine A2A receptor agonist improves cardiac dysfunction from pulmonary ischemia-reperfusion injury.

C. Tribble, J. Linden, A. Schulman, 2005, The Annals of thoracic surgery.

Microenvironment and Immunology Adenosine A 2 A Receptors Intrinsically Regulate CD 8 þ T Cells in the Tumor Microenvironment

J. Linden, C. Cekic, 2014 .

Reconstitution of bovine A1 adenosine receptors and G proteins in phospholipid vesicles: betagamma-subunit composition influences guanine nucleotide exchange and agonist binding.

J. Linden, M. Lindorfer, R. Figler, 1997, Biochemistry.

ATTENUATION OF REPERFUSION LUNG INJURY AND APOPTOSIS BY A2A ADENOSINE RECEPTOR ACTIVATION IS ASSOCIATED WITH MODULATION OF Bcl-2 AND Bax EXPRESSION AND ACTIVATION OF EXTRACELLULAR SIGNAL-REGULATED KINASES

S. Einav, I. Matot, E. Galun, 2007, Shock.

Receptors that inhibit phosphoinositide breakdown.

J. Linden, T. M. Delahunty, 1989, Trends in pharmacological sciences.

Correlation of adenosine thallium 201 perfusion patterns with markers for inducible ischemia.

G. Beller, M. Feldman, J. Linden, 1997, American heart journal.

NF-κB Is Activated in CD4+ iNKT Cells by Sickle Cell Disease and Mediates Rapid Induction of Adenosine A2A Receptors

D. Neuberg, J. Linden, D. Nathan, 2013, PloS one.

Effect of adrenergic and muscarinic cholinergic agonists on atrial natriuretic peptide secretion by isolated rat atria. Potential role of the autonomic nervous system in modulating atrial natriuretic peptide secretion.

J. Linden, M. Z. Baker, R. Schiebinger, 1987, The Journal of clinical investigation.

Reduction in myocardial infarct size at 48 hours after brief intravenous infusion of ATL-146e, a highly selective adenosine A2A receptor agonist.

C. Kramer, G. Beller, D. J. Meerdink, 2009, American journal of physiology. Heart and circulatory physiology.

Selective A2A adenosine agonist ATL-146e attenuates acute lethal liver injury in mice

Sumio Watanabe, M. Otaka, M. Odashima, 2005, Journal of Gastroenterology.

3- and 6-Substituted 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridines as A1 adenosine receptor allosteric modulators and antagonists.

P. Sexton, A. Christopoulos, J. Linden, 2009, Bioorganic & medicinal chemistry.

5-Substituted 2-aminothiophenes as A1 adenosine receptor allosteric enhancers.

J. Linden, P. Scammells, L. Aurelio, 2008, Bioorganic & medicinal chemistry.

2-Aminothiophene-3-carboxylates and carboxamides as adenosine A1 receptor allosteric enhancers.

G. Nikolakopoulos, J. Linden, P. Scammells, 2006, Bioorganic & medicinal chemistry.

6-aryl-8H-indeno[1,2-d]thiazol-2-ylamines: A1 adenosine receptor agonist allosteric enhancers having improved potency.

M. Chordia, J. Linden, T. Macdonald, 2005, Journal of medicinal chemistry.

2-Amino-3-benzoylthiophene allosteric enhancers of A1 adenosine agonist binding: new 3, 4-, and 5-modifications.

J. Linden, P. Scammells, R. Olsson, 2003, Journal of medicinal chemistry.

2-Aminothiazoles: a new class of agonist allosteric enhancers of A(1) adenosine receptors.

M. Chordia, J. Linden, T. Macdonald, 2002, Bioorganic & medicinal chemistry letters.

Hypertension Rapid Communication Modulation of Guanylate Cyclase by Lipoxygenase Inhibitors

J. Linden, 2005 .

A Novel Neutrophil-Speciﬁc PET Imaging Agent: cFLFLFK-PEG- 64 Cu

B. Kundu, Li Xiao, Yi Zhang, 2009 .

Recombinant Techniques as Applied to the Study of A1 Adenosine Receptors

J. Linden, 1995 .

Activation of adenosine 2A receptors preserves structure and function of podocytes.

J. Sedor, J. Linden, M. Okusa, 2008, Journal of the American Society of Nephrology : JASN.

Multivalent site-specific phage modification enhances the binding affinity of receptor ligands.

Jaymes R Beech, L. Saleh, J. Linden, 2015, Bioconjugate chemistry.

Pharmacology of purine and pyrimidine receptors. Preface.

K. Jacobson, J. Linden, 2011, Advances in Pharmacology.

Potent and orally bioavailable 8-bicyclo[2.2.2]octylxanthines as adenosine A1 receptor antagonists.

Xiaowei Jin, J. Linden, R. Petter, 2006, Journal of medicinal chemistry.

A2A adenosine receptor induction inhibits IFN-gamma production in murine CD4+ T cells.

J. Linden, J. Rieger, C. Lappas, 2005, Journal of immunology.

Synthesis and biological evaluation of the enantiomers of the potent and selective A1-adenosine antagonist 1,3-dipropyl-8-[2-(5,6-epoxynorbonyl)]-xanthine.

R. Lum, J. Linden, L. Belardinelli, 1997, Journal of medicinal chemistry.

Adenosine receptors: therapeutic aspects for inflammatory and immune diseases

Pál Pacher, B. Cronstein, J. Linden, 2006, Nature Reviews Drug Discovery.

Inhibition of ANP clearance receptors and endopeptidase 24.11 in maturing rats.

R. Carey, M. Peach, R. Chevalier, 1991, The American journal of physiology.

Inhibiting the inflammatory response in joint sepsis.

D. Diduch, J. Linden, W. Scheld, 2001, Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association.

Blockade of adenosine A2B receptors ameliorates murine colitis

S. Srinivasan, S. Mwangi, D. Merlin, 2008, British journal of pharmacology.

Quinazolines as adenosine receptor antagonists: SAR and selectivity for A2B receptors.

K. Jacobson, J. Linden, X. Ji, 2003, Bioorganic & medicinal chemistry.

Structure and function of A 1 adenosine receptors1

J. Linden, 1991, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Norbornyllactone-substituted xanthines as adenosine A(1) receptor antagonists.

Xiaowei Jin, J. Linden, R. Petter, 2006, Bioorganic & medicinal chemistry.

Regulation of GH3-cell function via adenosine A1 receptors. Inhibition of prolactin release, cyclic AMP production and inositol phosphate generation.

J. Linden, M. Cronin, T. M. Delahunty, 1988, The Biochemical journal.

Cardiovascular Biology of Purines

G. Burnstock, J. Linden, B. Liang, 1998, Developments in Cardiovascular Medicine.

Protection from ischemic liver injury by activation of A2A adenosine receptors during reperfusion: inhibition of chemokine induction.

Liping Huang, J. Linden, M. Okusa, 2004, American journal of physiology. Gastrointestinal and liver physiology.

Adenosine deaminase for removing adenosine: how much is enough?

J. Linden, 1989, Trends in pharmacological sciences.

Lipopolysaccharide rapidly modifies adenosine receptor transcripts in murine and human macrophages: role of NF-kappaB in A(2A) adenosine receptor induction.

J. Linden, Melissa A. Marshall, G. Sullivan, 2005, The Biochemical journal.

Gene dose effect reveals no Gs-coupled A2A adenosine receptor reserve in murine T-lymphocytes: studies of cells from A2A-receptor-gene-deficient mice.

J. F. Chen, M. Sitkovsky, C. Caldwell, 2001, The Biochemical journal.

The cardiac effects of adenosine.

R. Berne, J. Linden, L. Belardinelli, 1989, Progress in cardiovascular diseases.

Sodium intake markedly alters renal interstitial fluid adenosine.

J. Linden, H. Siragy, Joel Linden, 1996, Hypertension.

The Expression of Adenosine A2B Receptor on Antigen-Presenting Cells Suppresses CD8+ T-cell Responses and Promotes Tumor Growth

Bin Zhang, J. Linden, Jie Fan, 2020, Cancer Immunology Research.

Quantitative Relationship between β -adrenergic Receptor Number and Physiologic Responses as Studied with a Long-Lasting β -adrenergic Antagonist

G. Brooker, J. Linden, W. L. Terasaki, 1979 .

Neutrophil- and myeloperoxidase-mediated metabolism of reduced nimesulide: evidence for bioactivation.

M. Chordia, J. Linden, T. Macdonald, 2010, Chemical research in toxicology.

Role of adenosine in response to vascular inflammation.

J. Linden, 2012, Arteriosclerosis, thrombosis, and vascular biology.

Properties of recombinant adenosine receptors

A. Tucker, J. Linden, A. Robeva, 1993 .

Antagonism of the effects of adenosine and hypoxia on atrioventricular conduction time by two novel alkylxanthines: correlation with binding to adenosine A1 receptors.

J. Linden, L. Belardinelli, H. Clemo, 1987, The Journal of pharmacology and experimental therapeutics.

Cloned receptors and cardiovascular responses to adenosine.

A. Tucker, J. Linden, 1993, Cardiovascular research.

Synthesis and evaluation of new N6-substituted adenosine-5'-N-methylcarboxamides as A3 adenosine receptor agonists.

Shane M. Devine, P. White, S. Bottle, 2010, Bioorganic & medicinal chemistry.

Inosine binds to A3 adenosine receptors and stimulates mast cell degranulation.

R. K. Shepherd, B. Duling, J. Linden, 1997, The Journal of clinical investigation.

Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

V. Kuchroo, Wenda Gao, T. Strom, 2007, The Journal of experimental medicine.

Sickle cell disease (SCD), iNKT cells, and regadenoson infusion.

D. Neuberg, O. Onyekwere, J. Keefer, 2012, Transactions of the American Clinical and Climatological Association.

Regulation of leukocyte function by adenosine receptors.

J. Linden, 2011, Advances in pharmacology.

Adenosine A2A receptor antagonists exert motor and neuroprotective effects by distinct cellular mechanisms

C. Müller, R. Cunha, Liqun Yu, 2008, Annals of neurology.

Molecular cloning and characterization of the human A3 adenosine receptor.

J. Linden, H. Taylor, M. Jacobson, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Sepsis expands a CD39+ plasmablast population that promotes immunosuppression via adenosine-mediated inhibition of macrophage antimicrobial activity.

B. Ryffel, H. Nakaya, F. Cunha, 2021, Immunity.

The immunosuppressive role of adenosine A2A receptors in ischemia reperfusion injury and islet transplantation.

K. Brayman, J. Linden, M. Okusa, 2012, Current diabetes reviews.

Regulation of intestinal guanylate cyclase by the heat-stable enterotoxin of Escherichia coli (STa) and protein kinase C

R. Guerrant, C. Sears, J. Linden, 1992, Infection and immunity.

Pediatric tolerogenic DCs expressing CD4 and immunoglobulin‐like transcript receptor (ILT)‐4 secrete IL‐10 in response to Fc and adenosine

J. Burns, A. Tremoulet, J. Linden, 2018, European journal of immunology.

Canine mast cell adenosine receptors: cloning and expression of the A3 receptor and evidence that degranulation is mediated by the A2B receptor.

J. Linden, J. Auchampach, T. Wan, 1997, Molecular pharmacology.

Reduction of infarct size and postischemic inflammation from ATL-146e, a highly selective adenosine A2A receptor agonist, in reperfused canine myocardium.

G. Beller, M. Ruiz, D. Watson, 2005, American journal of physiology. Heart and circulatory physiology.

Cellular sensing of extracellular purine nucleosides triggers an innate IFN-β response

R. Nilsson, C. Benedict, Mohit M. Jain, 2020, Science Advances.

Adenosine A2A receptor activation limits graft‐versus‐host disease after allogenic hematopoietic stem cell transplantation

Courtney M. Lappas, J. Linden, H. Malech, 2010, Journal of leukocyte biology.

A2A Adenosine Receptors on Bone Marrow-Derived Cells Protect Liver from Ischemia-Reperfusion Injury1

J. Linden, J. Rieger, M. Okusa, 2005, The Journal of Immunology.

Renal protection from ischemia mediated by A2A adenosine receptors on bone marrow-derived cells.

Liping Huang, H. Ye, J. Linden, 2003, The Journal of clinical investigation.

Renal ischemia-reperfusion injury and adenosine 2A receptor-mediated tissue protection: role of macrophages.

Liping Huang, H. Ye, J. Linden, 2005, American journal of physiology. Renal physiology.

A(2A) adenosine receptor-mediated inhibition of renal injury and neutrophil adhesion.

J. Linden, J. Rieger, T. Macdonald, 2000, American journal of physiology. Renal physiology.

Effects of xanthine amine congener on hypoxic coronary resistance and venous and epicardial adenosine concentrations.

R. Berne, J. Linden, D. Sawmiller, 1994, Cardiovascular research.

Enhanced fibrinolysis protects against lung ischemia-reperfusion injury.

D. Pinsky, G. Ailawadi, J. Linden, 2009, The Journal of thoracic and cardiovascular surgery.

Adenosine and related compounds counteract tumor necrosis factor-alpha inhibition of neutrophil migration: implication of a novel cyclic AMP-independent action on the cell surface.

E. Hewlett, J. Linden, G. Mandell, 1990, Journal of immunology.

Properties of cardiac contractions in zero sodium solutions: intracellular free calcium controls slow channel conductance.

G. Brooker, J. Linden, 1980, Journal of molecular and cellular cardiology.

The influence of resting membrane potential on the effect of verapamil on atria.

G. Brooker, J. Linden, Joel Linden, 1980, Journal of molecular and cellular cardiology.

Sodium requirement for the positive inotropic action of isoproterenol on guinea pig atria.

G. Brooker, J. Linden, 1978, Science.

A2B Adenosine and P2Y2 Receptors Stimulate Mitogen-activated Protein Kinase in Human Embryonic Kidney-293 Cells

Taosheng Chen, M. Weber, J. Linden, 1999, The Journal of Biological Chemistry.

A REFLEX INCREASEINHEART RATE FROM DISTENSIONOF THE PULMONARY-VEIN-ATRIALJUNCTIONS

J. Linden, J. Andr, 1964 .

Adenosin eA2 AActivatio nAttenuate sNontransplantatio nLung Reperfusio nInjury

Ramesh Singh, C. Tribble, J. Linden, 2008 .

The A2B Adenosine Receptor Impairs the Maturation and Immunogenicity of Dendritic Cells 1

Jeffrey M. Wilson, J. Linden, J. Rieger, 2009, The Journal of Immunology.

Adenosine A2A receptor activation reduces hepatic ischemia reperfusion injury by inhibiting CD1d-dependent NKT cell activation

Courtney M. Lappas, V. Engelhard, J. Linden, 2006, The Journal of experimental medicine.

Immunohistochemical localization of adenosine A2A receptors in the rat central nervous system

J. Linden, A. Robeva, R. Woodard, 1998, The Journal of comparative neurology.

Antibody Mediated Depletion of iNKT Cells Protects Against Hypoxia-Induced Pulmonary Injury in a Murine Model of Sickle Cell Disease

R. Mashal, R. Schaub, J. Linden, 2014 .

Mouse spinal cord compression injury is reduced by either activation of the adenosine A2A receptor on bone marrow–derived cells or deletion of the A2A receptor on non-bone marrow–derived cells

J. Linden, J. Rieger, Y. Li, 2006, Neuroscience.

A2A adenosine receptor activation improves survival in mouse models of endotoxemia and sepsis.

J. Linden, W. Scheld, G. Sullivan, 2004, The Journal of infectious diseases.

Adenosine A2A analogue improves neurologic outcome after spinal cord trauma in the rabbit.

Jeffrey S. Young, C. Tribble, J. Linden, 2002, The Journal of trauma.

Enhanced protection from renal ischemia: Reperfusion injury with A2A-adenosine receptor activation and PDE 4 inhibition

David F. Smith, Liping Huang, J. Linden, 2001 .

Enhanced protection from renal ischemia-reperfusion [correction of ischemia:reperfusion] injury with A(2A)-adenosine receptor activation and PDE 4 inhibition.

J. Linden, M. Okusa, L. Huang, 2001, Kidney international.

Selective A2A adenosine receptor activation reduces ischemia-reperfusion injury in rat kidney.

Liping Huang, J. Linden, T. Macdonald, 1999, American journal of physiology. Renal physiology.

Purine Release, Metabolism, and Signaling in the Inflammatory Response.

F. Koch-Nolte, J. Linden, G. Dahl, 2019, Annual review of immunology.

Correction: NF-κB Is Activated in CD4+ iNKT Cells by Sickle Cell Disease and Mediates Rapid Induction of Adenosine A2A Receptors

J. Linden, D. Nathan, Joshua J Field, 2015, PloS one.

Ultrastructural localization of adenosine A2A receptors suggests multiple cellular sites for modulation of GABAergic neurons in rat striatum

J. Linden, D. Rosin, Amy Lee, 2001, The Journal of comparative neurology.

Cyclic AMP‐dependent inhibition of human neutrophil oxidative activity by substituted 2‐propynylcyclohexyl adenosine A2A receptor agonists

J. Linden, J. Rieger, T. Macdonald, 2001 .

Patterns of A2A extracellular adenosine receptor expression in different functional subsets of human peripheral T cells. Flow cytometry studies with anti-A2A receptor monoclonal antibodies.

M. Sitkovsky, J. Linden, M. Koshiba, 1999, Molecular pharmacology.

Design, synthesis, and evaluation of novel A2A adenosine receptor agonists.

J. Linden, J. Rieger, T. Macdonald, 2001, Journal of medicinal chemistry.

Activation of A2A adenosine receptor attenuates intestinal inflammation in animal models of inflammatory bowel disease.

C. Moskaluk, C. Nast, Sumio Watanabe, 2005, Gastroenterology.

A2A Adenosine Receptor Induction Inhibits IFN-γ Production in Murine CD4+ T Cells1

Courtney M. Lappas, J. Linden, J. Rieger, 2005, The Journal of Immunology.

Attenuation of gastric mucosal inflammation induced by aspirin through activation of A2A adenosine receptor in rats.

Sumio Watanabe, M. Otaka, M. Odashima, 2006, World journal of gastroenterology.

Adenosine A2A Receptor Signaling and Golf Assembly Show a Specific Requirement for the γ7 Subtype in the Striatum*

D. Hervé, J. Linden, William F Schwindinger, 2010, The Journal of Biological Chemistry.

Extracellular adenosine regulates naive T cell development and peripheral maintenance

J. Linden, Y. Day, Duygu Sag, 2013, The Journal of experimental medicine.

Right ventricular outflow tract tachycardia due to a somatic cell mutation in G protein subunitalphai2.

S. Markowitz, B. Lerman, J. Linden, 1998, The Journal of clinical investigation.

The A2B Adenosine Receptor Promotes Th17 Differentiation via Stimulation of Dendritic Cell IL-6

Jeffrey M. Wilson, J. Linden, W. Ross, 2011, The Journal of Immunology.

Augmentation of Muscle Blood Flow by Ultrasound Cavitation Is Mediated by ATP and Purinergic Signaling

J. Linden, J. Lindner, A. Ammi, 2017, Circulation.

Renal Ischemia-Reperfusion Injury and Adenosine 2A Receptor-Mediated Tissue Protection: The Role of CD4+ T Cells and IFN-γ1

Liping Huang, H. Ye, J. Linden, 2006, The Journal of Immunology.

Adenosine A2A agonists in development for the treatment of inflammation

Courtney M. Lappas, J. Linden, C. Lappas, 2005, Expert opinion on investigational drugs.

Effects of adenosine A2A receptor activation and alanyl-glutamine in Clostridium difficile toxin-induced ileitis in rabbits and cecitis in mice

R. Guerrant, J. Linden, J. Rieger, 2012, BMC Infectious Diseases.

Protection from pulmonary ischemia-reperfusion injury by adenosine A2A receptor activation

J. Linden, I. Kron, V. Laubach, 2009, Respiratory research.

Using Visualization of t-Distributed Stochastic Neighbor Embedding To Identify Immune Cell Subsets in Mouse Tumors

J. Linden, Joel Linden, Nicole V. Acuff, 2017, The Journal of Immunology.

Immune Cell Subsets in Mouse Tumors Stochastic Neighbor Embedding To Identify -Distributed t Using Visualization of

J. Linden, N. Acuff, 2017 .

Adenosine A2B Receptor Blockade Slows Growth of Bladder and Breast Tumors

R. Strieter, D. Theodorescu, J. Linden, 2012, The Journal of Immunology.

Adenosine Receptor A2A Deficiency in Leukocytes Increases Arterial Neointima Formation in Apolipoprotein E–Deficient Mice

Chunxiang Zhang, Chuhong Zhu, Huan Wang, 2010, Arteriosclerosis, thrombosis, and vascular biology.

Adenosine Receptor A 2 A Deficiency in Leukocytes Increases Arterial Neointima Formation in Apolipoprotein E – Deficient Mice

Chunxiang Zhang, Chuhong Zhu, Huan Wang, 2010 .

Adenosine A2B Receptor Blockade Slows Growth of Bladder and Breast Tumors

R. Strieter, D. Theodorescu, J. Linden, 2012, The Journal of Immunology.

Inactivation of the adenosine A2A receptor protects apolipoprotein E-deficient mice from atherosclerosis.

Chunxiang Zhang, Chuhong Zhu, Huan Wang, 2009, Arteriosclerosis, thrombosis, and vascular biology.

Adenosine A2A Receptor Stimulation Reduces Inflammation and Neointimal Growth in a Murine Carotid Ligation Model

J. Mcpherson, J. Linden, J. Rieger, 2001, Arteriosclerosis, thrombosis, and vascular biology.

The role of inflammation in vascular diseases

J. Linden, I. Sarembock, G W Sullivan, 2000, Journal of leukocyte biology.

Rapid modification of the glycocalyx caused by ischemia-reperfusion is inhibited by adenosine A2A receptor activation.

B. Duling, J. Linden, S. Platts, 2003, American journal of physiology. Heart and circulatory physiology.

An adenosine A2A agonist, ATL-146e, reduces paralysis and apoptosis during rabbit spinal cord reperfusion.

C. Tribble, J. Linden, J. Rieger, 2001, Journal of vascular surgery.

Targeting Adenosine with Adenosine Deaminase 2 to Inhibit Growth of Solid Tumors

H. Shepard, S. Deaglio, J. Linden, 2021, Cancer Research.

Optimization of a mouse locomotor rating system to evaluate compression-induced spinal cord injury: correlation of locomotor and morphological injury indices.

J. Linden, J. Kern, Y. Day, 2006, Journal of neurosurgery. Spine.

Identification and quantification of Gi-type GTP-binding proteins that copurify with a pituitary somatostatin receptor.

J. Linden, D. Luthin, C. Eppler, 1993, The Journal of biological chemistry.

Angiotensin II stimulates T-type Ca2+ channel currents via activation of a G protein, Gi.

P. Barrett, J. Linden, D. Luthin, 1996, The American journal of physiology.

Photoaffinity Labeling with 2‐[2‐(4‐Azido‐3‐[125I]‐Iodophenyl)ethylamino]adenosine and Autoradiography with 2‐[2‐(4‐Amino‐3‐[125I]Iodophenyl)ethylamino]adenosine of A2a Adenosine Receptors in Rat Brain

J. Linden, D. Luthin, David Okonkwo, 1995, Journal of neurochemistry.

Purification and partial amino acid sequence of a mu opioid receptor from rat brain.

G. Uhl, J. Linden, D. Luthin, 1993, The Journal of biological chemistry.

A Critical Role of the Adenosine A2A Receptor in Extrastriatal Neurons in Modulating Psychomotor Activity as Revealed by Opposite Phenotypes of Striatum and Forebrain A2A Receptor Knock-Outs

J. Tsien, R. Cunha, Liqun Yu, 2008, The Journal of Neuroscience.

A Crucial Role for Forebrain Adenosine A2A Receptors in Amphetamine Sensitization

J. Linden, E. Bastia, M. Schwarzschild, 2005, Neuropsychopharmacology.

Anatomy of adenosine A2A receptors in brain

Amy Lee, J. Linden, D. Rosin, 2003, Neurology.

Transgenic A1 adenosine receptor overexpression increases myocardial resistance to ischemia.

J. Linden, J. Headrick, G. Matherne, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Molecular Cloning and Characterization of the Human A_3 Adenosine Receptor

J. Linden, H. Taylor, M. Jacobson, 1993 .

The questionable role of cyclic guanosine 3':5'-monophosphate in heart.

G. Brooker, J. Linden, 1979, Biochemical pharmacology.

A1 adenosine receptors of bovine brain couple to guanine nucleotide-binding proteins Gi1, Gi2, and Go.

P. Sternweis, I. Pang, J. Linden, 1991, The Journal of biological chemistry.

Species comparison of adenosine and beta-adrenoceptors in mammalian atrial and ventricular myocardium.

M. Leid, T. F. Murray, J. Linden, 1993, European journal of pharmacology.

Sensitivity of Ca-dependent slow action potentials to methacholine is induced by phosphodiesterase inhibitors in embryonic chick ventricles.

J. Linden, N. Sperelakis, S. Vogel, 1982, The Journal of pharmacology and experimental therapeutics.

A2B adenosine receptor gene deletion attenuates murine colitis.

Dan Yang, K. Ravid, D. Merlin, 2008, Gastroenterology.

Genoprotective pathways. Part I. Extracellular signaling through G(s) protein-coupled adenosine receptors prevents oxidative DNA damage.

J. Linden, J. Holoshitz, Jie Zheng, 2004, Mutation research.

Adenosine A2B receptors are highly expressed on murine type II alveolar epithelial cells.

J. Linden, S. Ramos, Melissa A. Marshall, 2009, American journal of physiology. Lung cellular and molecular physiology.

New insights into the regulation of inflammation by adenosine.

J. Linden, 2006, The Journal of clinical investigation.

Characterization of human A(2B) adenosine receptors: radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells.

J. Linden, A. Robeva, J Linden, 1999, Molecular pharmacology.

Stimulation of A2A-adenosine receptors after myocardial infarction suppresses inflammatory activation and attenuates contractile dysfunction in the remote left ventricle.

B. A. French, C. Mathieu, L. Overbergh, 2006, American journal of physiology. Heart and circulatory physiology.

The structure and function of A1 and A2B adenosine receptors.

J. Linden, J. Auchampach, R. Figler, 1998, Life sciences.

Selective adenosine A2A receptor agonist, ATL‐146e, attenuates stress‐induced gastric lesions in rats

Sumio Watanabe, M. Otaka, M. Odashima, 2005 .

PD 81,723, an allosteric enhancer of the A1 adenosine receptor, lowers the threshold for ischemic preconditioning in dogs.

J. Linden, J. Auchampach, J Linden, 1996, Circulation research.

Contamination of adenosine deaminase by superoxide dismutase. Stabilization of endothelium-derived relaxing factor.

R. Johns, J. Linden, M. R. Prater, 1991, Biochemical pharmacology.

Characterization of Dahl salt-sensitive rats with genetic disruption of the A2B adenosine receptor gene: implications for A2B adenosine receptor signaling during hypertension

M. Dwinell, J. Linden, A. Geurts, 2015, Purinergic Signalling.

Human retinal pigment epithelial cells in culture possess A2-adenosine receptors

P. Campochiaro, J. Linden, S. Hackett, 1989, Brain Research.

Human retinal pigment epithelial cells possess V1 vasopressin receptors.

P. Campochiaro, J. Linden, Z. Friedman, 1991, Current eye research.

Purification of 125I-labeled succinyl cyclic nucleotide tyrosine methyl esters by high-performance liquid chromatography.

J. Linden, A. Patel, 1988, Analytical biochemistry.

treatment of guinea pigs with theophylline. Enhanced sensitivity of heart cells to adenosine and up-regulation of receptor number after

Sheng-Nan Wu, J. Linden, L. Belardinelli, 2013 .

Solid phase enzyme immunoassay of cyclic adenosine 3',5'-monophosphate. Effect of coating strategy upon assay performance in comparison with radioimmunoassay.

J. Linden, D. Taylor, G. Vandenhoff, 1992, Journal of immunological methods.

Agonist and Antagonist Radioligands and Photoaffinity Labels for the Adenosine A1 Receptor

J. Linden, R. Craig, S. Daluge, 1987 .

Differential expression of A2a, A1-adenosine and D2-dopamine receptor genes in rat peripheral arterial chemoreceptors during postnatal development

F. Northington, J. Linden, D. Rosin, 2000, Brain Research.

Adenosine A2A Receptors in Bone Marrow-Derived Cells But Not in Forebrain Neurons Are Important Contributors to 3-Nitropropionic Acid-Induced Striatal Damage as Revealed by Cell-Type-Selective Inactivation

Liqun Yu, J. Linden, J. Coelho, 2006, The Journal of Neuroscience.

Abnormal Regulation of Microvascular Tone in a Murine Model of Sickle Cell Disease Assessed by Contrast Ultrasound.

J. Linden, J. Lindner, Y. Qi, 2015, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

Augmentation of Limb Perfusion and Reversal of Tissue Ischemia Produced by Ultrasound-Mediated Microbubble Cavitation

J. Linden, J. Lindner, A. Ammi, 2015, Circulation. Cardiovascular imaging.

Activation of A2A adenosine receptors inhibits expression of α4/β1 integrin (very late antigen‐4) on stimulated human neutrophils

Courtney M. Lappas, M. Lawrence, J. Linden, 2004 .

Links Between Insulin Resistance, Adenosine A2B Receptors, and Inflammatory Markers in Mice and Humans

J. Pankow, B. Fredholm, S. Rich, 2011, Diabetes.

The Second Extracellular Loop of the Adenosine A1 Receptor Mediates Activity of Allosteric Enhancers

Ruben Abagyan, Fiona M. McRobb, Mark Yeager, 2014, Molecular Pharmacology.

125I-BW-A844U, an antagonist radioligand with high affinity and selectivity for adenosine A1 receptors, and 125I-azido-BW-A844U, a photoaffinity label.

J. Linden, A. Patel, R. Craig, 1988, Molecular pharmacology.

Calculating the dissociation constant of an unlabeled compound from the concentration required to displace radiolabel binding by 50%.

J. Linden, 1982, Journal of cyclic nucleotide research.

Synthesis of novel neutrophil-specific imaging agents for Positron Emission Tomography (PET) imaging.

B. Kundu, Yi Zhang, D. Pan, 2007, Bioorganic & medicinal chemistry letters.

Evidence for persistent activation of cardiac slow channels in low-calcium solutions.

G. Brooker, J. Linden, 1982, The American journal of physiology.

Neutrophil A2A adenosine receptor inhibits inflammation in a rat model of meningitis: synergy with the type IV phosphodiesterase inhibitor, rolipram.

J. Linden, W. Scheld, G. Sullivan, 1999, The Journal of infectious diseases.

Right Ventricular Outflow Tract Tachycardia Due To a Somatic Cell Mutation in G Protein Subunit

S. Markowitz, B. Lerman, J. Linden, 1998 .

Adenosine receptors in GtoPdb v.2021.2

B. Fredholm, K. Klotz, K. Jacobson, 2021, IUPHAR/BPS Guide to Pharmacology CITE.

Adenosine A(2B) receptor deficiency promotes host defenses against gram-negative bacterial pneumonia.

M. Burdick, J. Linden, B. Mehrad, 2012, American journal of respiratory and critical care medicine.

Ups and downs of adenosine

J. Linden, 2006 .

Activation of Adenosine A2a Receptors Inhibits Mast Cell Degranulation and Mast Cell‐Dependent Vasoconstriction

R. K. Shepherd, B. Duling, J. Linden, 2000, Microcirculation.

Adenosine-induced vasoconstriction in vivo. Role of the mast cell and A3 adenosine receptor.

R. K. Shepherd, B. Duling, J. Linden, 1996, Circulation research.

Nucleoside-induced arteriolar constriction: a mast cell-dependent response.

B. Duling, J. Linden, M. P. Doyle, 1994, The American journal of physiology.

Molecular cloning and functional expression of a sheep A3 adenosine receptor with widespread tissue distribution.

A. Tucker, S. Rivkees, S. Reppert, 1993, Molecular pharmacology.

Attenuation of gastric mucosal inflammation induced by indomethacin through activation of the A2A adenosine receptor in rats

Sumio Watanabe, M. Otaka, M. Odashima, 2009, Journal of Gastroenterology.

Adenosine in Tissue Protection and Tissue Regeneration

J. Linden, 2005, Molecular Pharmacology.

Subcellular distributions of adenosine A1 and A2A receptors in the rat dorsomedial nucleus of the solitary tract at the level of the area postrema

V. Pickel, J. Linden, J. Chan, 2006, Synapse.

Characterization of 8-(N-methylisopropyl)amino-N6-(5'-endohydroxy- endonorbornyl)-9-methyladenine (WRC-0571), a highly potent and selective, non-xanthine antagonist of A1 adenosine receptors.

R. Wysocki, J. Linden, J. May, 1996, The Journal of pharmacology and experimental therapeutics.

THE ADENOSINE RECEPTOR MOLECULE

J. Linden, 1991 .

Characterization of Dahl salt-sensitive rats with genetic disruption of the A2B adenosine receptor gene: implications for A2B adenosine receptor signaling during hypertension

M. Dwinell, J. Linden, A. Geurts, 2015, Purinergic Signalling.

Ontogeny of rat myocardial A1 adenosine receptors.

J. Linden, H. Taylor, G. Matherne, 1995, Biology of the Neonate.

Lidocaine enhances Galphai protein function.

J. Linden, M. Hollmann, M. Durieux, 2003, Anesthesiology.

Human A2A Adenosine Receptors: High-Affinity Agonist Binding to Receptor-G Protein Complexes Containing Gβ4

J. Linden, J. Rieger, T. Macdonald, 2002 .

Influence of differential stability of G protein βγ dimers containing the γ11 subunit on functional activity at the M1 muscarinic receptor, A1 adenosine receptor, and phospholipase C-β.

J. Linden, W. McIntire, J. Garrison, 2006, Biochemistry.

Adenosine A2A agonist reduces paralysis after spinal cord ischemia: correlation with A2A receptor expression on motor neurons.

C. Tribble, J. Linden, J. Rieger, 2002, The Annals of thoracic surgery.

Infarct-Sparing Effect of A2A-Adenosine Receptor Activation Is Due Primarily to Its Action on Lymphocytes

B. A. French, J. Linden, Y. Day, 2005, Circulation.

A comparison of adenosine A2A agonism and methylprednisolone in attenuating neuronal damage and improving functional outcome after experimental traumatic spinal cord injury in rabbits.

D. Okonkwo, C. Tribble, J. Linden, 2006, Journal of neurosurgery. Spine.

Adenosine A2B receptors are highly expressed on murine type II alveolar epithelial cells.

J. Linden, S. Ramos, Melissa A. Marshall, 2009, American journal of physiology. Lung cellular and molecular physiology.

Adenosine metabolism and cancer. Focus on "Adenosine downregulates DPPIV on HT-29 colon cancer cells by stimulating protein tyrosine phosphatases and reducing ERK1/2 activity via a novel pathway".

J. Linden, 2006, American journal of physiology. Cell physiology.

A1 adenosine receptors. Two amino acids are responsible for species differences in ligand recognition.

A. Tucker, J. Linden, A. Robeva, 1994, The Journal of biological chemistry.

Antiadrenergic action of adenosine on ventricular myocardium in embryonic chick hearts.

R. Berne, J. Linden, L. Belardinelli, 1982, Journal of molecular and cellular cardiology.

Co-purification of A1 adenosine receptors and guanine nucleotide-binding proteins from bovine brain.

J. Linden, R. Munshi, 1989, Journal of Biological Chemistry.

Antagonists of the Receptor-G Protein Interface Block Gi-coupled Signal Transduction*

T. Dunwiddie, H. Hamm, C. Lupica, 1998, The Journal of Biological Chemistry.

Characteristics of A1 Adenosine Receptors and Guanine Nucleotide Binding Proteins Co-Purified from Bovine Brain

J. Linden, A. Patel, M. Arroyo, 1990 .

Downregulation and desensitization of A1-adenosine receptors in embryonic chicken heart.

J. Linden, J. Shryock, L. Belardinelli, 1989, The American journal of physiology.

Purinergic Chemotaxis

J. Linden, 2006, Science.

Pharmacology of purine and pyrimidine receptors

Kenneth A. Jacobsen, J. Linden, 2011 .

Purification and characterization of (-)[125I]hydroxyphenylisopropyladenosine, an adenosine R-site agonist radioligand and theoretical analysis of mixed stereoisomer radioligand binding.

J. Linden, 1984, Molecular Pharmacology.

Regioselective oxidation of 2-amino-3-aroyl-4,5-dialkylthiophenes by DMSO.

M. Chordia, J. Linden, T. Macdonald, 2004, Bioorganic & medicinal chemistry letters.

Adenosine A2A receptor agonists inhibit lipopolysaccharide-induced production of tumor necrosis factor-alpha by equine monocytes.

T. F. Murray, M. Vandenplas, Wan‐chun Sun, 2008, Veterinary immunology and immunopathology.

Xenopus oocyte K+ current. III. Phorbol esters and pH regulate current at gap junctions.

J. T. Hackett, L. Greenfield, J. Linden, 1990, The American journal of physiology.

Improved detection of ischemia-induced increases in coronary sinus adenosine in patients with coronary artery disease.

T. Skalak, M. Feldman, C. Ayers, 1992, Clinical chemistry.

Selective adenosine A(2a) receptor agonists reduce the apoptosis in an experimental model of spinal cord trauma.

F. Pedata, E. Mazzon, S. Cuzzocrea, 2010, Journal of biological regulators and homeostatic agents.

Adenosine A2A receptor activation reduces recurrence and mortality from Clostridium difficile infection in mice following vancomycin treatment.

R. Guerrant, J. Linden, J. Rieger, 2012, BMC infectious diseases.

Adenosine A2A Receptor (A2AR) agonists improve survival in K28-hACE2 mice following SARS CoV-2 infection

K. Brayman, J. Linden, B. Mann, 2022, bioRxiv.

Adenosine A2A analogue ATL-146e reduces systemic tumor necrosing factor-alpha and spinal cord capillary platelet-endothelial cell adhesion molecule-1 expression after spinal cord ischemia.

C. Tribble, J. Linden, J. Rieger, 2002, Journal of vascular surgery.

Autoregulation of cyclic AMP in vascular smooth muscle: a role for adenosine receptors.

J. Linden, 2002, Molecular pharmacology.

Kinetic profiling and functional characterization of 8-phenylxanthine derivatives as A2B adenosine receptor antagonists

K. Jacobson, A. IJzerman, H. de Vries, 2022, Biochemical pharmacology.

From Atherosclerosis Deficient Mice - Receptor Protects Apolipoprotein E 2A Inactivation of the Adenosine A

Chuhong Zhu, Chaodong Wu, J. Linden, 2012 .

Sodium Requirement for Effects of Ouabain on Contraction of Isolated Guinea Pig Atria

G. Brooker, J. Linden, 1980, Circulation research.

Palmitoylation of the recombinant human A1 adenosine receptor: enhanced proteolysis of palmitoylation-deficient mutant receptors.

J. Linden, G. Szabó, Z. Gao, 1999, The Biochemical journal.

A2B adenosine receptor gene deletion attenuates murine colitis.

Dan Yang, K. Ravid, D. Merlin, 2008, Gastroenterology.

CD73 is expressed by human regulatory T helper cells and suppresses proinflammatory cytokine production and Helicobacter felis-induced gastritis in mice.

J. Linden, Soumita Das, S. Crowe, 2009, The Journal of infectious diseases.

Pediatric tolerogenic DCs expressing CD4 and immunoglobulin‐like transcript receptor (ILT)‐4 secrete IL‐10 in response to Fc and adenosine

J. Burns, A. Tremoulet, J. Linden, 2018, European journal of immunology.

A2AR Adenosine Signaling Suppresses Natural Killer Cell Maturation in the Tumor Microenvironment.

Deborah S. Barkauskas, N. Waddell, L. Zitvogel, 2018, Cancer research.

Compartmentalization of neutrophils in the kidney and lung following acute ischemic kidney injury.

J. Reutershan, Liping Huang, H. Cathro, 2009, Kidney international.

Regulation of lymphocyte function by adenosine.

J. Linden, C. Cekic, 2012, Arteriosclerosis, thrombosis, and vascular biology.

International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors.

B. Fredholm, K. Klotz, K. Jacobson, 2001, Pharmacological reviews.

Adenosine A2A Receptor Signaling and Golf Assembly Show a Specific Requirement for the γ7 Subtype in the Striatum*

D. Hervé, J. Linden, J. Robishaw, 2010, The Journal of Biological Chemistry.

A1 Adenosine Receptor Activation Promotes Angiogenesis and Release of VEGF From Monocytes

A. Tucker, Xiaoping Liu, J. Linden, 2007, Circulation research.

G. Beller, M. Ruiz, D. Glover, 2002, Circulation.

Adenosine A2A receptor agonist (regadenoson) in human lung transplantation.

M. Conaway, G. Petroni, J. Beller, 2020, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Improved survival of SARS COV-2-infected K18-hACE2 mice treated with adenosine A2AR agonist

K. Brayman, J. Linden, P. Chhabra, 2023, Heliyon.

Cloning and pharmacological characterization of the equine adenosine A2A receptor: a potential therapeutic target for the treatment of equine endotoxemia.

T. F. Murray, M. Vandenplas, J. Linden, 2006, Journal of veterinary pharmacology and therapeutics.

The Positive Inotropic Action of Sulfonylureas: A Mechanism Independent of Cyclic Adenosine 3',5'-Monophosphate

G. Brooker, J. Linden, 1978, Diabetes.

Surfactants alter the oxygen tension of buffers: an artifactual component of the inotropic response to sulfonylureas in rat atria.

G. Brooker, J. Linden, 1977, Federation proceedings.