J. Décout

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Synthesis and transfection properties of a series of lipidic neamine derivatives.

T. Montier, T. Le Gall, P. Lehn, 2009, Bioconjugate chemistry.

Targeting Bacterial Cardiolipin Enriched Microdomains: An Antimicrobial Strategy Used by Amphiphilic Aminoglycoside Antibiotics

P. van der Smissen, J. Décout, Micheline El Khoury, 2017, Scientific Reports.

Flavin-oligonucleotide conjugates: sequence specific photocleavage of DNA

M. Fontecave, J. Mouscadet, J. Décout, 1998 .

DNA detection through signal amplification by using NADH: flavin oxidoreductase and oligonucleotide-flavin conjugates as cofactors.

M. Fontecave, J. Décout, P. Simon, 2005, Angewandte Chemie.

Origins of life: Molecular foundations and new approaches

M. Maurel, J. Décout, Marie-Christine Maurel, 1999 .

Combining theoretical and experimental data to decipher CFTR 3D structures and functions

J. Mornon, I. Callebaut, P. Lehn, 2018, Cellular and Molecular Life Sciences.

Effect of cardiolipin on the antimicrobial activity of a new amphiphilic aminoglycoside derivative on Pseudomonas aeruginosa

P. van der Smissen, J. Décout, Micheline El Khoury, 2018, PloS one.

Sequence-specific nucleic acid damage induced by peptide nucleic acid conjugates that can be enzyme-activated.

M. Fontecave, J. Décout, P. Simon, 2006, Angewandte Chemie.

New Broad-Spectrum Antibacterial Amphiphilic Aminoglycosides Active against Resistant Bacteria: From Neamine Derivatives to Smaller Neosamine Analogues.

J. Décout, Micheline El Khoury, Guillaume Sautrey, 2016, Journal of medicinal chemistry.

Tuning the antibacterial activity of amphiphilic neamine derivatives and comparison to paromamine homologues.

I. Baussanne, J. Décout, Myriam M. Ouberai, 2013, Journal of medicinal chemistry.

Thymidine‐Psoralen Photoaddition: Stereoselective Formation of A trans‐syn Pyrone Adduct

J. Décout, J. Lhomme, A. Guendouz, 1996 .

REVERSIBLE PHOTOCYCLOADDITION OF A 4′,5′‐DIHYDROPSORALEN DERIVATIVE WITH THYMINE

J. Décout, J. Lhomme, Jean Lhomme, 1992, Photochemistry and photobiology.

THE THYMIDINE‐PSORALEN PHOTOADDITION. A MODEL APPROACH

J. Décout, J. Lhomme, Y. Lekchiri, 1992 .

The Pseudomonas aeruginosa membranes: a target for a new amphiphilic aminoglycoside derivative?

R. Brasseur, L. Lins, D. Alsteens, 2011, Biochimica et biophysica acta.

Antimicrobial activity of amphiphilic neamine derivatives: Understanding the mechanism of action on Gram-positive bacteria.

P. van der Smissen, J. Décout, Micheline El Khoury, 2019, Biochimica et biophysica acta. Biomembranes.

Negatively Charged Lipids as a Potential Target for New Amphiphilic Aminoglycoside Antibiotics

L. Lins, J. Décout, Micheline El Khoury, 2016, The Journal of Biological Chemistry.

Bicyclic 5-6 Systems—Purines

J. Décout, 2020 .

Aptamer-based enantioselective competitive binding assay for the trace enantiomer detection.

E. Peyrin, C. Ravelet, I. Baussanne, 2007, Analytical chemistry.

Fluorescent deazaflavin-oligonucleotide probes for selective detection of DNA.

P. Peltié, M. Fontecave, J. Décout, 2002, Angewandte Chemie.

Discovery of alpha-aminoazaheterocycle-methylglyoxal adducts as a new class of high affinity inhibitors of CFTR chloride channels.

J. Décout, F. Bossard, C. Gauthier, 2007 .

Sequence-specific photo-induced cross-linking of the two strands of double-helical DNA by a psoralen covalently linked to a triple helix-forming oligonucleotide.

J. Décout, M. Takasugi, J. Lhomme, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Major increases of the reactivity and selectivity in aminoglycoside O-alkylation due to the presence of fluoride ions

E. Peyrin, I. Baussanne, J. Décout, 2012 .

Origins of life: Molecular foundations and new approaches

M. Maurel, J. Décout, 1999 .

Anti-retroviral and cytostatic activity of 2',3'-dideoxyribonucleoside 3'-disulfides.

J. Balzarini, J. Décout, J. Désiré, 2008, Bioorganic & medicinal chemistry.

Targeting different binding sites in the CFTR structures allows to synergistically potentiate channel activity.

J. Mornon, I. Callebaut, P. Lehn, 2020, European journal of medicinal chemistry.

Amphiphilic Aminoglycosides as Medicinal Agents

J. Décout, M. Mingeot-Leclercq, J. Kempf, 2020, International journal of molecular sciences.

A peptide nucleic acid-aminosugar conjugate targeting transactivation response element of HIV-1 RNA genome shows a high bioavailability in human cells and strongly inhibits tat-mediated transactivation of HIV-1 transcription.

I. Baussanne, J. Décout, J. Désiré, 2012, Journal of medicinal chemistry.

A peptide nucleic acid-neamine conjugate that targets and cleaves HIV-1 TAR RNA inhibits viral replication.

J. Décout, J. Désiré, B. Chaubey, 2004, Journal of medicinal chemistry.

Detection and production of nitric oxide

M. Fontecave, J. Décout, C. Garrel, 1995 .

Interest of Homodialkyl Neamine Derivatives against Resistant P. aeruginosa, E. coli, and β-Lactamases-Producing Bacteria—Effect of Alkyl Chain Length on the Interaction with LPS

J. Décout, Jitendriya Swain, M. Mingeot-Leclercq, 2021, International journal of molecular sciences.

An evolutionary conserved detoxification system for membrane lipid–derived peroxyl radicals in Gram-negative bacteria

G. Cosa, J. Décout, M. Valvano, 2022, PLoS biology.

Sequence-targeted photosensitized reactions in nucleic acids by oligo-alpha-deoxynucleotides and oligo-beta-deoxynucleotides covalently linked to proflavin.

D. Praseuth, J. Décout, J. Lhomme, 1988, Biochemistry.

Synthesis and antimicrobial evaluation of amphiphilic neamine derivatives.

I. Baussanne, S. Halder, J. Décout, 2010, Journal of medicinal chemistry.

Combining theoretical and experimental data to decipher CFTR 3D structures and functions

J. Mornon, I. Callebaut, P. Lehn, 2018, Cellular and Molecular Life Sciences.

New 7-methylguanine derivatives targeting the influenza polymerase PB2 cap-binding domain.

Joe D. Lewis, S. Cusack, D. Guilligay, 2013, Journal of medicinal chemistry.

Key steps from the “RNA World” to the “DNA World”

J. Décout, S. Chambert, Brice-Loïc Renard, 2014 .

Pharmacological chaperones improve intra-domain stability and inter-domain assembly via distinct binding sites to rescue misfolded CFTR

J. Mornon, I. Sermet-Gaudelus, I. Callebaut, 2021, Cellular and Molecular Life Sciences.

Neamine dimers targeting the HIV-1 TAR RNA.

V. Ludwig, Oliver Boden, M. Göbel, 2005, Bioorganic & medicinal chemistry letters.

RECENT DEVELOPMENTS IN THE SYNTHESIS, CHEMICAL MODIFICATIONS AND BIOLOGICAL APPLICATIONS OF SULFUR MODIFIED NUCLEOSIDES, NUCLEOTIDES AND OLIGONUCLEOTIDES

J. Décout, S. Chambert, 2002 .

Synthesis of 2′-thio-uridine and -cytidine derivatives as potential inhibitors of ribonucleoside diphosphate reductase: thionitrites, disulfides and 2′-thiouridine 5′-diphosphate

M. Fontecave, J. Décout, L. L. H. D. Fallois, 1997 .

Bacterial lipid membranes as promising targets to fight antimicrobial resistance, molecular foundations and illustration through the renewal of aminoglycoside antibiotics and emergence of amphiphilic aminoglycosides

J. Décout, M. Mingeot-Leclercq, 2016 .

A One-Pot Synthesis of Highly Functionalized Purines.

I. Callebaut, J. Décout, B. Boucherle, 2017, Organic letters.

Synthesis of 2′-Thiouridine and -cytidine Derivatives as Potential Inhibitors of Ribonucleoside Diphosphate Reductase: Thionitrites, Disulfides and 2′-Thiouridine 5′-Diphosphate.

M. Fontecave, J. Décout, L. L. H. D. Fallois, 2010 .

Thionucleotides as Inhibitors of Ribonucleotide Reductase

J. Décout, B. Roy, S. Chambert, 2003, Nucleosides, nucleotides & nucleic acids.

Inactivation of Escherichia coli ribonucleotide reductase by 2'-deoxy-2'-mercaptouridine 5'-diphosphate. Electron paramagnetic resonance evidence for a transient protein perthiyl radical.

J. Covès, M. Fontecave, J. Décout, 1996, Biochemistry.

Deoxyribonucleoside 2'- or 3'-mixed disulfides: prodrugs to target ribonucleotide reductase and/or to inhibit HIV reverse transcription.

J. Balzarini, J. Décout, A. Aubertin, 2003, Journal of medicinal chemistry.

Mechanism of RNA cleavage catalyzed by sequence specific polyamide nucleic acid-neamine conjugate.

I. Baussanne, J. Décout, J. Désiré, 2007, Oligonucleotides.

Decomposition of FK 409, a new vasodilator: Identification of nitric oxide as a metabolite

Paul H. Williams, M. Fontecave, J. Décout, 1995 .

Unusual addition of amines to C-2 of vinyl sulfone-modified-beta-D-pent-2-enofuranosyl carbohydrates: synthesis of a new class of beta-anomeric 2-amino-2,3-dideoxy-D-threo-pentofuranosides.

C. G. Suresh, J. Décout, T. Pathak, 2008, Carbohydrate research.

INTERACTIONS AND PHOTOREACTIVITY OF 5‐ALKOXYPSORALENS WITH THYMINE. A MODEL APPROACH

J. Décout, J. Lhomme, G. Huart, 1988, Photochemistry and photobiology.

Medicinal chemistry of antischistosomal drugs: Praziquantel and oxamniquine.

J. Décout, V. R. D. da Silva, J. F. de Oliveira, 2017, Bioorganic & medicinal chemistry.

Copper(II) complexes of lipophilic aminoglycoside derivatives for the amino acid enantiomeric separation by ligand-exchange liquid chromatography.

E. Peyrin, C. Ravelet, I. Baussanne, 2008, Journal of chromatography. A.

Hydrolysis of 2′-deoxypurine nucleosides. The effect of substitution at the C-8 position

J. Décout, A. Laayoun, J. Lhomme, 1994 .

Enantioseparation by MEKC using a ligand exchange‐based chiral pseudostationary phase

E. Peyrin, C. Ravelet, I. Baussanne, 2009, Electrophoresis.

Chiral ligand-exchange chromatography of amino acids using porous graphitic carbon coated with a dinaphthyl derivative of neamine

E. Peyrin, A. Ravel, C. Ravelet, 2009, Analytical and bioanalytical chemistry.

Covalently bonded DNA aptamer chiral stationary phase for the chromatographic resolution of adenosine

E. Peyrin, C. Ravelet, J. Décout, 2008, Analytical and Bioanalytical Chemistry.

Sequence-specific recognition, photocrosslinking and cleavage of the DNA double helix by an oligo-[alpha]-thymidylate covalently linked to an azidoproflavine derivative.

D. Praseuth, T. Doan, J. Décout, 1987, Nucleic acids research.

The NAD(P)H:Flavin Oxidoreductase from Escherichia coli

M. Fontecave, F. Fieschi, J. Décout, 1999, The Journal of Biological Chemistry.

Design of molecules that specifically recognize and cleave apurinic sites in DNA

J. Constant, N. Berthet, J. Décout, 1994, Journal of molecular recognition : JMR.

The Mechanism and Substrate Specificity of the NADPH:Flavin Oxidoreductase from Escherichia coli(*)

M. Fontecave, F. Fieschi, J. Décout, 1995, The Journal of Biological Chemistry.

Oligoribonucleotide Synthesis by the Phosphite Procedure from 2′-Dimethoxytritylated Nucleosides

J. Décout, K. K. Ogilvie, 1985 .

Selective 5′-desilylation of 3′,5′-disilyi AraU derivatives under basic conditions

M. Fontecave, J. Décout, L. L. H. D. Fallois, 1995 .

Hydrolysis of oligonucleotides containing 8-substituted purine nucleosides. A new route for preparing abasic oligodeoxynucleotides

J. Décout, A. Laayoun, J. Lhomme, 1994 .

Discovery of α-Aminoazaheterocycle-Methylglyoxal Adducts as a New Class of High-Affinity Inhibitors of Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channels

J. Décout, F. Bossard, C. Gauthier, 2007, Journal of Pharmacology and Experimental Therapeutics.

8-Azidoadenosine and ribonucleotide reductase.

M. Fontecave, J. Décout, J. Lhomme, 1992, Biochemical and biophysical research communications.

Studies of nucleic acid-like polymers as catalysts

M. Maurel, J. Décout, 1992, Journal of Molecular Evolution.

A New Straightforward Synthesis of 2', 3'-Didehydro-2', 3'-dideoxy-2'-(2"- (trimethylsilyl)ethylthio)thymidine, Key Intermediate for the Synthesis of 2'-Substituted Thionucleosides

M. Lima, S. Galdino, J. Décout, 2015 .

A route for preparing new neamine derivatives targeting HIV-1 TAR RNA

C. Bailly, J. Décout, J. Désiré, 2004 .

RNA‐acting antibiotics: in‐vitro selection of RNA aptamers for the design of new bioactive molecules less susceptible to bacterial resistance

M. Maurel, J. Décout, M. Reboud-Ravaux, 2002, The Journal of pharmacy and pharmacology.

Antibiotic drugs aminoglycosides cleave DNA at abasic sites: shedding new light on their toxicity?

J. Constant, J. Décout, Marine Peuchmaur, 2013, Chemical research in toxicology.

Broad-spectrum antibacterial amphiphilic aminoglycosides: A new focus on the structure of the lipophilic groups extends the series of active dialkyl neamines.

J. Décout, Jitendriya Swain, Louis Zimmermann, 2018, European journal of medicinal chemistry.

2-(trimethylsilyl)ethanethiol in nucleoside chemistry. A short route for preparing thionucleosides and their methyl disulfides.

M. Fontecave, J. Décout, I. Gautier-Luneau, 2000, The Journal of organic chemistry.

Direct preparation of nucleoside vinyl disulfides from 2-(trimethylsilyl)ethyl sulfides, an access to vinylthiols.

J. Décout, J. Désiré, Béatrice Gerland, 2007, Organic letters.

Reversed-phase high-performance liquid chromatography, a tool for the study of bichromophoric systems including polymethylenic linking bridges

J. Décout, J. Lhomme, B. Mouchel, 1989 .

INTERACTIONS AND PHOTOREACTIVITY OF 8‐ALKOXYPSORALENS WITH THYMINE. A MODEL APPROACH

J. Décout, J. Lhomme, 1988, Photochemistry and photobiology.

Bichromophoric Systems to Study the Base-Psoralen Photoreactions

J. Décout, J. Lhomme, 1988 .

SYNTHETIC MODELS RELATED TO DNA‐INTERCALATING MOLECULES. INTERACTIONS BETWEEN 8‐ALKOXYPSORALEN AND ADENINE *

J. Décout, J. Lhomme, Jean Lhomme, 1983, Photochemistry and photobiology.

Synthetic models related to dna-intercalating molecules a study of the ring-ring stacking interactions between 8-alkoxypsoralen and thymine.

J. Décout, J. Lhomme, 1981 .

Solid state photodimerization of psoralen derivatives

J. Décout, J. Lhomme, C. Courseille, 1990 .

A Short Chemically Modified dsRNA-Binding PNA (dbPNA) Inhibits Influenza Viral Replication by Targeting Viral RNA Panhandle Structure.

Lixia Yang, J. Décout, Mookkan Prabakaran, 2019, Bioconjugate chemistry.

Possible prebiotic catalysts formed from adenine and aldehyde

M. Maurel, J. Décout, J. Vergne, 2000 .

Synthesis and Evaluation of 2‐Aminothiophene Derivatives as Staphylococcus aureus Efflux Pump Inhibitors

J. Décout, M. Mingeot-Leclercq, F. Mendonça-Junior, 2020, ChemMedChem.

A Reagentless Biosensor for the Amperometric Determination of NADH

S. Cosnier, M. Fontecave, C. Innocent, 1998 .

Pharmacological chaperones improve intra-domain stability and inter-domain assembly via distinct binding sites to rescue misfolded CFTR

J. Mornon, I. Sermet-Gaudelus, I. Callebaut, 2021, Cellular and Molecular Life Sciences.

In Vitro Rescue of the Bile Acid Transport Function of ABCB11 Variants by CFTR Potentiators

I. Callebaut, J. Décout, Y. Riahi, 2022, International journal of molecular sciences.

New stereoselective reaction of methylglyoxal with 2-aminopyridine and adenine derivatives: formation of imino acid-nucleic base derivatives in water under mild conditions.

M. Maurel, J. Décout, J. Vergne, 2002, Chemical communications.

A new 9-alkyladenine-cyclic methylglyoxal diadduct activates wt- and F508del-cystic fibrosis transmembrane conductance regulator (CFTR) in vitro and in vivo.

J. Décout, C. Norez, F. Becq, 2014, European journal of medicinal chemistry.

An expeditious access to 5-pyrimidinol derivatives from cyclic methylglyoxal diadducts, formation of argpyrimidines under physiological conditions and discovery of new CFTR inhibitors.

J. Décout, C. Norez, F. Becq, 2011, European journal of medicinal chemistry.

Identification of a novel water-soluble activator of wild-type and F508del CFTR: GPact-11a

J. Décout, C. Jayle, C. Norez, 2010, European Respiratory Journal.

6‐Chloropurine Ribonucleosides from Chloropyrimidines: One‐Pot Synthesis

J. Décout, Wael Zeinyeh, R. Zelli, 2018, Current protocols in nucleic acid chemistry.

CFTR corrector efficacy is associated with occupancy of distinct binding sites

J. Mornon, I. Sermet-Gaudelus, I. Callebaut, 2021, bioRxiv.

RNA Secondary Structure-Based Design of Antisense Peptide Nucleic Acids for Modulating Disease-Associated Aberrant Tau Pre-mRNA Alternative Splicing

R. Kierzek, X. Roca, J. Décout, 2019, Molecules.

N6-substituted adenine derivatives and RNA primitive catalysts

M. Maurel, J. Décout, 1993, Origins of life and evolution of the biosphere.

NMR studies of binding of 5-FdUDP and dCDP to ribonucleoside-diphosphate reductase from Escherichia coli.

M. Fontecave, J. Décout, S. Kuprin, 1995, Biochimica et biophysica acta.

A structure-based approach for targeting the HIV-1 genomic RNA dimerization initiation site.

P. Dumas, J. Décout, S. Bernacchi, 2007, Biochimie.

Method for Preparing New Flavin Derivatives: Synthesis of Flavin−Thymine Nucleotides and Flavin−Oligonucleotide Adducts

M. Fontecave, J. Décout, C. Frier, 1997 .

New flavin and deazaflavin oligonucleotide conjugates for the amperometric detection of DNA hybridization.

S. Cosnier, M. Fontecave, C. Gondran, 2004, Chemical communications.

Adenine-Aptamer Complexes

Jacques Vergne, M. Maurel, J. Décout, 2002, The Journal of Biological Chemistry.

Targeting Bacterial Cardiolipin Enriched Microdomains: An Antimicrobial Strategy Used by Amphiphilic Aminoglycoside Antibiotics

P. van der Smissen, J. Décout, Micheline El Khoury, 2017, Scientific Reports.

New Amphiphilic Neamine Derivatives Active against Resistant Pseudomonas aeruginosa and Their Interactions with Lipopolysaccharides

J. Décout, Guillaume Sautrey, Louis Zimmermann, 2014, Antimicrobial Agents and Chemotherapy.

, Alicia Lipopolysaccharides aeruginosa and Their Interactions with Active against Resistant Pseudomonas New Amphiphilic Neamine Derivatives

J. Décout, Guillaume Sautrey, Louis Zimmermann, 2014 .

Broad-spectrum antibacterial amphiphilic aminoglycosides: A new focus on the structure of the lipophilic groups extends the series of active dialkyl neamines.

J. Décout, Jitendriya Swain, Louis Zimmermann, 2018, European journal of medicinal chemistry.

Is the NAD(P)H:Flavin Oxidoreductase from Escherichia coli a Member of the Ferredoxin-NADP+ Reductase Family?

M. Fontecave, F. Fieschi, J. Décout, 1996, The Journal of Biological Chemistry.