J. Littlefield

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Partial trisomies in two spontaneously arising long-lived human keratinocyte lines

J. Weaver, G. Stetten, J. Littlefield, 1991, In Vitro Cellular & Developmental Biology - Animal.

Computer-Assisted Analysis of Chromosomal Abnormalities: Detection of a Deletion in Aniridia/ Wilms' Tumor Syndrome

P. Neurath, J. Littlefield, R. Ladda, 1974, Science.

Repetitive synchronization of human lymphoblast cultures with excess thymidine.

H. R. Zielke, J. Littlefield, 1974, Methods in cell biology.

Urinary tract epithelial cells cultured from human urine.

J. Littlefield, J. Felix, 1979, International review of cytology. Supplement.

Control mechanisms in animal cell cultures.

J. Littlefield, 1968, Archives of biochemistry and biophysics.

DIABETES MELLITUS AND AGING: DIMINISHED PLATING EFFICIENCY OF CULTURED HUMAN FIBROBLASTS

S. Goldstein, J. Littlefield, J. Soeldner, 1969 .

Three Degrees of Guanylic Acid — Inosinic Acid Pyrophosphorylase Deficiency in Mouse Fibroblasts

J. Littlefield, 1964, Nature.

Infection of Thymidine Kinase-Deficient BHK Cells with Polyoma Virus

J. Littlefield, C. Basilico, JOHN W. LITTLEFIELD, 1966, Nature.

Prenatal genetic diagnosis. I.

J. Littlefield, J. Kanfer, V. Shih, 1970, The New England journal of medicine.

The use of drug-resistant markers to study the hybridization of mouse fibroblasts.

J. Littlefield, 1966, Experimental cell research.

THE SELECTION OF HYBRID MOUSE FIBROBLASTS.

J. Littlefield, 1964, Cold Spring Harbor symposia on quantitative biology.

Nitrosoguanidine mutagenesis in synchronized hamster cells

S. Orkin, J. Littlefield, 1971 .

Selection of Morphologically Normal Cell Lines from Polyoma-transformed BHK21/13 Hamster Fibroblasts

J. Littlefield, G. Marin, 1968, Journal of Virology.

Chemical mutagenesis at the phosphoribosyltransferase locus in cultured human lymphoblasts.

J. Littlefield, K. Sato, R. Slesinski, 1972, Proceedings of the National Academy of Sciences of the United States of America.

Studies on alpha-ketoglutaric oxidase. I. Formation of "active" succinate.

J. Littlefield, D. Sanadi, 1951, The Journal of biological chemistry.

Analysis of HGPRT− CRM+ human lymphoblast mutants

J. Littlefield, A. Leyva, G. Ghangas, 1979, Somatic cell genetics.

IgA deficiency associated with partial deletion of chromosome 18.

J. Littlefield, R. Schwartz, C. Bartsocas, 1969, American journal of diseases of children.

Techniques for Using HAT Selection in Somatic Cell Genetics

W. Choy, J. Littlefield, T. V. Gopalakrishnan, 1982 .

Mechanism of incorporation of labeled amino acids into protein.

M. Hoagland, P. Zamecnik, J. Littlefield, 1956, Journal of cellular physiology. Supplement.

Studies on cytoplasmic ribonucleoprotein particles from the liver of the rat.

P. Zamecnik, J. Littlefield, J. Gross, 1955, The Journal of biological chemistry.

Metabolic cooperation in aggregates of embryonal carcinoma cells.

J. Littlefield, 1987, Developmental biology.

Isolation and characterization of the multiple forms of dihydrofolate reductase from methotrexate-resistant hamster cells.

J. Littlefield, U. Hänggi, 1974, The Journal of biological chemistry.

Purification, properties, and synthesis of dihydrofolate reductase from wild type and methotrexate-resistant hamster cells.

J. Littlefield, H. Nakamura, 1972, The Journal of biological chemistry.

Hybridization of hamster cells with high and low folate reductase activity.

J. Littlefield, 1969, Proceedings of the National Academy of Sciences of the United States of America.

Research on Cellular Senescence: Present and Future Directions

W. Choy, J. Epstein, J. Littlefield, 1977 .

Studies on the overproduction of dihydrofolate reductase by variant hamster cells in culture.

S. Orkin, J. Littlefield, H. Nakamura, 1976, Advances in enzyme regulation.

Mutagenesis to aminopterin resistance in cultured hamster cells.

S. Orkin, J. Littlefield, 1971, Experimental cell research.

Studies on the Mechanism of Protein Synthesis

M. Stephenson, P. Zamecnik, J. Littlefield, 1958 .

The toxic effect of 5-bromodeoxyuridine on cultured epithelial cells.

J. Littlefield, E. Gould, 1960, The Journal of biological chemistry.

Natural Occurrence of Thymine and Three Methylated Adenine Bases in Several Ribonucleic Acids

J. Littlefield, D. B. Dunn, 1958, Nature.

Loss of expression of the uvomorulin gene in compaction-defective embryonal carcinoma cells

J. Littlefield, D. Weng, 1991, Somatic cell and molecular genetics.

Absence of uvomorulin in a slowly compacting variant of H6 embryonal carcinoma cells

J. Littlefield, L. L. Whitehouse, 1990, Somatic cell and molecular genetics.

Changes in the distribution of polymerase activity during DNA synthesis in mouse fibroblasts.

J. Littlefield, A. McGovern, K. B. Margeson, 1963, Proceedings of the National Academy of Sciences of the United States of America.

Studies on alpha-ketoglutaric oxidase. II. Purification and properties.

J. Littlefield, R. Bock, D. Sanadi, 1952, The Journal of biological chemistry.

Prenatal genetic diagnosis (second of three parts).

J. Littlefield, J. Kanfer, V. Shih, 1970, The New England journal of medicine.

RNA from rat hepatoma cells can activate phenylalanine hydroxylase gene of mouse erythroleukemia cells

J. Littlefield, T. V. Gopalakrishnan, 1983, Somatic cell genetics.

Prenatal Genetic Diagnosis: Status and Problems

J. Littlefield, L. B. Jacoby, A. Milunsky, 1973 .

"Derivation of Pluripotent Stem Cells from Cultured Human Primordial Germ Cells" (1998), by John Gearhart et al.

J. Axelman, J. Gearhart, P. Donovan, 2012 .

Derivation of pluripotent stem cells from cultured human primordial germ cells

Peter J. Donovan, J. Axelman, J. Gearhart, 1998 .

THE REPLICATION OF THE MINOR DNA COMPONENT OF MOUSE FIBROBLASTS.

J. Littlefield, E. H. Chun, 1963, Journal of molecular biology.

Immunoglobulins in De Lange syndrome.

J. Littlefield, J. Crawford, C. Bartsocas, 1968, Lancet.

Some aspects of somatic cell hybridization

S. Goldstein, J. Littlefield, 1970, In Vitro.

The Early History of Mammalian Somatic Cell Fusion

J. Littlefield, 1987 .

Prenatal genetic diagnosis. 3.

J. Littlefield, V. Shih, E. Kolodny, 1970, The New England journal of medicine.

Isolation and characterization of norleucine-resistant baby hamster kidney cells.

J. Littlefield, D. Kamely, 1974, Experimental cell research.

The prenatal diagnosis of inborn errors of metabolism.

J. Littlefield, A. Milunsky, 1972, Annual review of medicine.

Variation, Senescence, and Neoplasia in Cultured Somatic Cells

J. Littlefield, 1975 .

Some properties of DNA from shope papilloma virus

J. Watson, J. Littlefield, 1960 .

Hypoxanthine-guanine phosphoribosyltransferase in human erythroid cells: posttranslational modification.

H. Kazazian, A. Ramage, J. Littlefield, 1982, Biochemistry.

Alpha-Ketoglutaric dehydrogenase. IV. Coupled phosphorylation.

J. Littlefield, D. Sanadi, H. Hift, 1953, The Journal of biological chemistry.

Selection of Hybrids from Matings of Fibroblasts in vitro and Their Presumed Recombinants

J. Littlefield, 1964, Science.

Human epithelial cells cultured from urine: Growth properties and keratin staining

T. Sun, J. Littlefield, J. Felix, 1980, In Vitro.

Rescue of terminally differentiating teratocarcinoma cells by fusion to undifferentiated parental cells

J. Littlefield, J. Felix, 1982, Somatic cell genetics.

Serum alkaline phosphatase in hypophosphatasia.

W. Fishman, J. Littlefield, J. Warshaw, 1971, The Journal of clinical investigation.

Aggregation-deficient embryonal carcinoma cells: defects in peanut agglutinin (PNA) receptors.

J. Littlefield, S. Kartha, J. Felix, 1985, Differentiation; research in biological diversity.

Derivation and Differentiation of Human Embryonic Germ Cells

J. Axelman, C. Kerr, J. Gearhart, 2004 .

The periodic synthesis of thymidine kinase in mouse fibroblasts.

J. Littlefield, John W. Littlefield, 1966, Biochimica et biophysica acta.

STUDIES ON THYMIDINE KINASE IN CULTURED MOUSE FIBROBLASTS.

J. Littlefield, 1965, Biochimica et biophysica acta.

Human newborn urine as a source of epithelial cells.

J. Littlefield, J. Felix, 1980, Birth defects original article series.

Problems in the use of cultured amniotic fluid cells for biochemical diagnoses.

J. Littlefield, 1971, Birth defects original article series.

NUCLEAR RNA SYNTHESIS IN PARTIALLY SYNCHRONIZED MOUSE FIBROBLASTS.

J. Littlefield, J. M. Reiter, 1964, Biochimica et biophysica acta.

DNA synthesis in partially synchronized L cells.

J. Littlefield, 1962, Experimental cell research.

Mutagen-induced diploid human lymphoblast variants containing altered hypoxanthine guanine phosphoribosyl transferase

J. Littlefield, W. N. Kelley, A. Leyva, 1977, Somatic cell genetics.

Mutagenic effect of BUdR in diploid human fibroblasts.

R. Stark, J. Littlefield, 1974, Mutation research.

Biochemistry of Viral Infection

J. Littlefield, M. Swartz, 1960 .

The extraembryonic endodermal differentiation and polyploidization of embryonal carcinoma cells in vitro.

J. Littlefield, E. Ilgren, 1981, Differentiation; research in biological diversity.

Adaptation in Lesch-Nyhan cells exposed to aminopterin.

V. Riccardi, J. Littlefield, 1972, Experimental cell research.

Endoderm-secreted factor stimulates growth of embryonal carcinoma stem cells

J. Littlefield, Emily L. Germain, 1986, In Vitro Cellular & Developmental Biology.

Stepwise aggregation, compaction, and differentiation of uncompacted F9 cells.

J. Littlefield, 1989, Developmental genetics.

Compaction-defective embryonal carcinoma cell variants.

J. Littlefield, 1989, Developmental genetics.

Calcium-induced compaction and its inhibition in embryonal carcinoma cell aggregates.

J. Littlefield, S. Kartha, J. Felix, 1983, Developmental biology.

Research on cystic fibrosis.

J. Littlefield, 1981, The New England journal of medicine.

The occurrence and distribution of thymine and three methylated-adenine bases in ribonucleic acids from several sources.

J. Littlefield, D. B. Dunn, 1958, The Biochemical journal.

Studies on 5-methylcytosine in L-cell deoxyribonucleic acid.

J. Littlefield, K. B. Margeson, A. P. cGOVERN, 1962, Biochimica et biophysica acta.

Altered regulation of the rate of synthesis of dihydrofolate reductase in methotrexate-resistant hamster cells.

J. Littlefield, U. Hänggi, 1976, The Journal of biological chemistry.

Hypoxanthine transport in normal and hypoxanthine guanine phosphoribosyltransferase (HGPRT) deficient diploid human lymphoblasts.

J. Littlefield, J. Epstein, 1977, Experimental cell research.

The Prenatal Diagnosis of Hereditary Disorders

J. Littlefield, A. Milunsky, 1974 .

Origin of chromosome rearrangements in two long-lived human keratinocyte lines

P. Pearson, G. Stetten, J. Littlefield, 1991, In Vitro Cellular & Developmental Biology - Animal.

Effect of Insulin on the Conversion of Glucose-C-14 to C-14-02 by Normal and Diabetic Fibroblasts in Culture

S. Goldstein, J. Littlefield, 1969, Diabetes.

On the difficulty of combining basic research and patient care.

J. Littlefield, 1984, American journal of human genetics.

Polyploidy in prenatal genetic diagnosis.

J. Littlefield, L. Atkins, A. Milunsky, 1971, The Journal of pediatrics.

Attempted hybridizations with senescent human fibroblasts

J. Littlefield, 1973, Journal of cellular physiology.

THE INOSINIC ACID PYROPHOSPHORYLASE ACTIVITY OF MOUSE FIBROBLASTS PARTIALLY RESISTANT TO 8-AZAGUANINE.

J. Littlefield, 1963, Proceedings of the National Academy of Sciences of the United States of America.

Genes, chromosomes, and cancer.

J. Littlefield, 1984, The Journal of pediatrics.

Genetic basis for a mouse model of down syndrome

J. Gearhart, R. Reeves, J. Littlefield, 1986, Brain Research Bulletin.

Assay of hypoxanthine-guanine phosphoribosyltransferase in human fibroblast lysates: inactivation of nucleotidase.

J. Littlefield, G. Johnson, 1979, Analytical biochemistry.

Possible supplemental mechanisms in the pathogenesis of AIDS.

J. Littlefield, 1992, Clinical immunology and immunopathology.

Reservations concerning gene therapy.

J. Littlefield, M. Fox, 1971, Science.

Macrocytic anemia.

J. Littlefield, 1948, American practitioner and digest of treatment.

The expression of genetic information.

J. Littlefield, 1963, The New England journal of medicine.

Retinoblastoma: chromosome banding in patients with heritable tumour.

R. Pruett, J. Littlefield, R. Ladda, 1973, Lancet.

Regulation of 5-methyltetrahydrofolate: homocysteine methyltransferase activity by methionine, vitamin B12, and folate in cultured baby hamster kidney cells.

J. Littlefield, R. Erbe, D. Kamely, 1973, Proceedings of the National Academy of Sciences of the United States of America.

The need to promote careers that combine research and clinical care.

J. Littlefield, 1986, Journal of Medical Education.

The relation between DNA and protein synthesis in mouse fibroblasts.

J. Littlefield, P. S. Jacobs, John W. Littlefield, 1965, Biochimica et biophysica acta.

Human embryonic germ cell derivatives express a broad range of developmentally distinct markers and proliferate extensively in vitro.

J. Axelman, J. Gearhart, Yan Cui, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Escape from senescence in human keratinocyte cultures

J. Littlefield, 1996, Experimental Gerontology.

Diagnostic limitations of metachromasia.

J. Littlefield, A. Milunsky, 1969, The New England journal of medicine.

The separation of the light and heavy strands of bromouracil-substituted mammalian DNA†

J. Littlefield, E. H. Chun, 1961 .

Argininosuccinase deficiency in fibroblasts cultured from patients with argininosuccinic aciduria

H. Moser, J. Littlefield, V. Shih, 1969, Biochemical Genetics.

Elevated dihydrofolate reductase messenger RNA levels in methotrexate-resistant BHK cells

J. Littlefield, Sidney E. Chang, 1976, Cell.

Free amino acids in extracts of cultured skin fibroblasts from patients with various amino acid metabolic disorders

J. Littlefield, H. Levy, V. Shih, 1975, Clinical genetics.

A microassay for argininosuccinase in cultured cells.

J. Littlefield, V. Shih, A. Milunsky, 1972, American journal of human genetics.

Incorporation of C14-amino acids into ribonucleoprotein particles from the Ehrlich mouse ascites tumor.

J. Littlefield, E. Keller, 1957, The Journal of biological chemistry.

Chapter 30 – Derivation and Differentiation of Human Embryonic Germ Cells

J. Axelman, C. Kerr, J. Gearhart, 2014 .

Chapter 28 – Derivation and Differentiation of Human Embryonic Germ Cells

J. Axelman, C. Kerr, J. Gearhart, 2013 .

1306 NEURAL CREST INVOLVEMENT IN MOUSE TRISOMY 16 EMBRYOPATHY

M. Oster-Granite, J. Gearhart, M. Msall, 1985, Pediatric Research.

1285 PLACENTAL DEVELOPMENT IN THE TRISOMY 16 MOUSE

J. Gearhart, J. Littlefield, G. Hatzidimitriou, 1985, Pediatric Research.

Different timing of increases in activities of four X-chromosome linked enzymes during the cell cycle of synchronized human lymphoblasts.

H. R. Zielke, J. Littlefield, S. Hong, 1976, Experimental cell research.

Altered chloride metabolism in cultured cystic fibrosis skin fibroblasts.

P. Maloney, J. Littlefield, P. Mattes, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Derivation of pluripotent stem cells from cultured human primordial germ cells.

J. Axelman, J. Gearhart, P. Donovan, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Folic acid deficiency secondary to a diet for maple syrup urine disease.

J. Littlefield, H. Levy, J. Truman, 1970, The Journal of pediatrics.

The pregnancy at risk for a genetic disorder.

J. Littlefield, 1970, New England Journal of Medicine.

Prenatal diagnosis and therapeutic abortion.

J. Littlefield, 1969, The New England journal of medicine.

Isolation and characterization of the multiple forms of dihydrofolate reductase from methotrexate-resistant hamster cells.

J. Littlefield, U. Hänggi, 1974, The Journal of biological chemistry.

HGPRT in the Gilles de la Tourette syndrome.

H. Singer, J. Littlefield, G. Johnson, 1977, The New England journal of medicine.

Amniocentesis for Prenatal Genetic Studies

J. Littlefield, L. Atkins, A. Milunsky, 1972, Obstetrics and gynecology.