Howard Y. Chen

发表

In ovo transfection of chicken embryos using cationic liposomes

C. Rosenblum, Howard Y. Chen, 1995, Transgenic Research.

Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass

Yue Feng, Donald J. Marsh, J. Metzger, 2000, Nature Genetics.

by a Farnesyl : Protein Transferase Inhibitor Develop Mammary Carcinomas That Can Be Growth-inhibited B Transgenic Mice ras Mouse Mammary Tumor Virus-Ki-Updated

R. Diehl, A. Kral, J. Davide, 2000 .

Effects of melanocortin receptor activation and blockade on ethanol intake: a possible role for the melanocortin-4 receptor.

G. Breese, Howard Y. Chen, D. Marsh, 2005, Alcoholism, clinical and experimental research.

Diet induction of monocyte chemoattractant protein-1 and its impact on obesity.

Chunsheng Zhang, J. Lamb, H. Dai, 2005, Obesity research.

Generation of mice expressing the human glucagon receptor with a direct replacement vector

Howard Y. Chen, M. Cascieri, L. Shiao, 1999, Transgenic Research.

Differential regulation of neuropeptide Y receptors in the brains of NPY knock-out mice

Howard Y. Chen, X. Guan, Hong Yu, 2001, Peptides.

Spiroindane based amides as potent and selective MC4R agonists for the treatment of obesity.

Howard Y. Chen, R. Nargund, M. Wyvratt, 2010, Bioorganic & medicinal chemistry letters.

Discovery of highly potent and efficacious MC4R agonists with spiroindane N-Me-1,2,4-triazole privileged structures for the treatment of obesity.

M. Reibarkh, Howard Y. Chen, R. Nargund, 2010, Bioorganic & medicinal chemistry letters.

Discovery of potent, selective, and orally bioavailable 3H-spiro[isobenzofuran-1,4'-piperidine] based melanocortin subtype-4 receptor agonists.

D. Macintyre, Howard Y. Chen, R. Nargund, 2010, Bioorganic & medicinal chemistry letters.

Somatostatin receptor subtype 5 regulates insulin secretion and glucose homeostasis.

H. Wilkinson, D. Szalkowski, Howard Y. Chen, 2003, Molecular endocrinology.

APP Knockout and APP Over-Expression in Transgenic Mice

G. Dawson, S. Boyce, Gurparkash Singh, 1997 .

Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist.

D. Macintyre, Howard Y. Chen, R. Nargund, 2010, Bioorganic & medicinal chemistry letters.

Targeted Disruption of a B2 Bradykinin Receptor Gene in Mice Eliminates Bradykinin Action in Smooth Muscle and Neurons (*)

C. Strader, J. Hess, Howard Y. Chen, 1995, The Journal of Biological Chemistry.

Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase

C. Nathan, Howard Y. Chen, G. Hom, 1995, Cell.

Discovery and activity of (1R,4S,6R)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide (3, RY764), a potent and selective melanocortin subtype-4 receptor agonist.

J. Metzger, D. Macintyre, L. V. D. van der Ploeg, 2005, Bioorganic & Medicinal Chemistry Letters.

Mutant Human Presenilin 1 Protects presenilin 1 Null Mouse against Embryonic Lethality and Elevates Aβ1–42/43 Expression

Gurparkash Singh, Hui Zheng, S. Qian, 1998, Neuron.

β-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

G. Dawson, S. Boyce, Hui Zheng, 1995, Cell.

Neither Agouti-Related Protein nor Neuropeptide Y Is Critically Required for the Regulation of Energy Homeostasis in Mice

D. Macneil, S. Qian, L. V. D. van der Ploeg, 2002, Molecular and Cellular Biology.

Congenital Deafness and Sinoatrial Node Dysfunction in Mice Lacking Class D L-Type Ca2+ Channels

J. Engel, Howard Y. Chen, S. Bova, 2000, Cell.

Therapeutic potential of histamine H3 receptor agonist for the treatment of obesity and diabetes mellitus

D. Macneil, R. Yoshimoto, H. Kotani, 2006, Proceedings of the National Academy of Sciences.

Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist.

D. Macintyre, Howard Y. Chen, R. Nargund, 2011, Bioorganic & medicinal chemistry letters.

Optimization of privileged structures for selective and potent melanocortin subtype-4 receptor ligands.

J. Metzger, L. V. D. van der Ploeg, C. Rosenblum, 2010, Bioorganic & medicinal chemistry letters.

The role of melanocortins in body weight regulation: opportunities for the treatment of obesity.

M. Tota, M. Bednarek, D. Macneil, 2002, European journal of pharmacology.

Mice Lacking Adiponectin Show Decreased Hepatic Insulin Sensitivity and Reduced Responsiveness to Peroxisome Proliferator-activated Receptor γ Agonists*

N. Ruderman, L. Rossetti, E. Tomás, 2006, Journal of Biological Chemistry.

Regulation of energy homeostasis by bombesin receptor subtype-3: selective receptor agonists for the treatment of obesity.

M. Reitman, J. Metzger, Yan Dong, 2010, Cell metabolism.

11β-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice

R. Thieringer, J. Metzger, B. Pikounis, 2005, The Journal of experimental medicine.

Role of the melanocortin-4 receptor in metabolic rate and food intake in mice

J. Metzger, D. Macintyre, M. Forrest, 2000, Transgenic Research.

Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism

Yue Feng, D. Macneil, J. Metzger, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists.

M. Reitman, J. Metzger, Mark Hadden, 2010, Bioorganic & medicinal chemistry letters.

Induction of neuropeptide Y expression in dorsomedial hypothalamus of diet‐induced obese mice

L. V. D. van der Ploeg, Howard Y. Chen, X. Guan, 1998, Neuroreport.

Resistance to fever induction and impaired acute-phase response in interleukin-1 beta-deficient mice.

A. Shaw, Howard Y. Chen, M. Kluger, 1995, Immunity.

G. Dawson, G. Dawson, S. Boyce, 1999, Neuroscience.

Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein.

D. Macneil, Roy G. Smith, S. Qian, 2004, Endocrinology.

Generation of APLP2 KO Mice and Early Postnatal Lethality in APLP2/APP Double KO Mice

D. Price, Howard Y. Chen, S. Sisodia, 1997, Neurobiology of Aging.

Somatostatin receptor subtype 2 knockout mice are refractory to growth hormone-negative feedback on arcuate neurons.

Roy G. Smith, L. V. D. van der Ploeg, Howard Y. Chen, 1997, Molecular endocrinology.

Susceptibility of stromelysin 1-deficient mice to collagen-induced arthritis and cartilage destruction.

J. Mudgett, Howard Y. Chen, H. Chen, 1998, Arthritis and rheumatism.

11beta-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice.

R. Thieringer, J. Metzger, B. Pikounis, 2005, The Journal of experimental medicine.

Therapeutic potential of histamine H3 receptor agonist for the treatment of obesity and diabetes mellitus

D. Macneil, R. Yoshimoto, H. Kotani, 2006, Proceedings of the National Academy of Sciences.

Increases in circulating insulin-like growth factor I levels by the oral growth hormone secretagogue MK-0677 in the beagle are dependent upon pituitary mediation.

Roy G. Smith, Howard Y. Chen, G. Hickey, 1999, Endocrinology.

Spiroindane based amides as potent and selective MC4R agonists for the treatment of obesity.

Howard Y. Chen, R. Nargund, M. Wyvratt, 2010, Bioorganic & Medicinal Chemistry Letters.