M. Kan

发表

Human Fibroblast Growth Factor-Binding Protein HBp17 Enhances the Tumorigenic Potential of Immortalized Squamous Epithelial Cells

Dianqing Wu, Xiaozhen Liu, S. Shi, 2002 .

A rare premalignant prostate tumor epithelial cell syndecan-1 forms a fibroblast growth factor-binding complex with progression-promoting ectopic fibroblast growth factor receptor 1.

X. Wu, Xiaochong Wu, M. Kan, 2001, Cancer research.

Heparin-binding growth factor type 1 (acidic fibroblast growth factor): a potential biphasic autocrine and paracrine regulator of hepatocyte regeneration.

P. Månsson, Jiansheng Huang, B. Carr, 1989, Proceedings of the National Academy of Sciences of the United States of America.

The heparan sulfate-fibroblast growth factor family: diversity of structure and function.

M. Kan, W. Mckeehan, Fen Wang, 1998, Progress in nucleic acid research and molecular biology.

Identification of tyrosines 154 and 307 in the extracellular domain and 653 and 766 in the intracellular domain as phosphorylation sites in the heparin‐binding fibroblast growth factor receptor tyrosine kinase (flg)

S. Carr, M. Huddleston, M. Kan, 1993, Protein science : a publication of the Protein Society.

Substitution of putative half-cystine residues in heparin-binding fibroblast growth factor receptors. Loss of binding activity in both two and three loop isoforms.

J. Xu, M. Kan, W. Mckeehan, 1992, The Journal of biological chemistry.

Primary culture of human gallbladder epithelial cells

M. Kan, T. Toyota, Koju Kobayashi, 1991, Gastroenterologia Japonica.

Requirement for Anticoagulant Heparan Sulfate in the Fibroblast Growth Factor Receptor Complex*

X. Wu, Xiaochong Wu, M. Kan, 1999, The Journal of Biological Chemistry.

Media for Culture of Mammalian Cells

M. Kan, J. Sato, 1998, Current protocols in cell biology.

Up-regulation of the chondrogenic Sox9 gene by fibroblast growth factors is mediated by the mitogen-activated protein kinase pathway.

S. Murakami, B. de Crombrugghe, M. Kan, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Fibroblast Growth Factor Receptor 2 Limits and Receptor 1 Accelerates Tumorigenicity of Prostate Epithelial Cells 1

A. Matsubara, M. Kan, W. Mckeehan, 2006 .

The fibroblast growth factor family

M. Kan, W. Mckeehan, 1998 .

Inositolhexakisphosphate (InsP6): An antagonist of fibroblast growth factor receptor binding and activity

K. Palczewski, M. Kan, W. Mckeehan, 1994, In Vitro Cellular & Developmental Biology - Animal.

Heparan sulfate is required for interaction and activation of the epithelial cell fibroblast growth factor receptor-2IIIb with stromal-derived fibroblast growth factor-7

M. Kan, Jun-Hyeog Jang, Fen Wang, 1997, In Vitro Cellular & Developmental Biology - Animal.

Heparin-binding growth factor gene expression and receptor characteristics in normal rat prostate and two transplantable rat prostate tumors.

P. Månsson, M. Kan, W. Mckeehan, 1989, Cancer research.

Reconstitution of a pentameric complex of dimeric transforming growth factor beta ligand and a type I, II, III receptor in baculoviral-infected insect cells

K. Matsuzaki, M. Kan, W. Mckeehan, 1996, In Vitro Cellular & Developmental Biology - Animal.

Ligand-dependent and -independent interactions with the transforming growth factor type II and I receptor subunits reside in the aminoterminal portion of the ectodomain of the type III subunit

A. Taniguchi, K. Matsuzaki, M. Kan, 1998, In Vitro Cellular & Developmental Biology - Animal.

Fibroblast Growth Factor-10

Y. Luo, M. Kan, W. Mckeehan, 1999, The Journal of Biological Chemistry.

Reply to the letter to the editor

M. Kan, T. Okamoto, J. Sato, 2020, The Journal of pediatrics.

MOLECULAR DIAGNOSIS OF HUMAN SALIVARY GLAND TUMORS BY DIFFERENTIAL EXPRESSION OF FIBROBLAST GROWTH FACTOR RECEPTOR GENES

Yoshiharu Tanaka, M. Kan, T. Okamoto, 1997 .

Expression of fibroblast growth factor receptor genes in human hepatoma-derived cell lines

Yoshiharu Tanaka, K. Chayama, M. Kan, 2003, In Vitro Cellular & Developmental Biology - Animal.

Structural specificity in a FGF7‐affinity purified heparin octasaccharide required for formation of a complex with FGF7 and FGFR2IIIb

S. Ye, M. Kan, W. Mckeehan, 2006, Journal of cellular biochemistry.

Fibroblast products adsorb to the culture substrate and stimulate growth of human umbilical vein endothelial cells

M. Kan, I. Yamane, Miwa Kato, 1985, Journal of cellular physiology.

EFFECT OF FGF‐1 AND FGF‐2 ON VEGF BINDING TO HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS

M. Kan, J. Sato, J. H. Chen, 2001, Cell biology international.

Effects of ceruloplasmin and the haptoglobin-hemoglobin complex on the oxygen-dependent reduction in growth of human diploid fibroblasts in serum-free, albumin containing medium.

R. Sasaki, M. Kan, I. Yamane, 1983, Cell structure and function.

Fibronectin, not laminin, mediates heparin-dependent heparin-binding growth factor type I binding to substrata and stimulation of endothelial cell growth

M. Kan, E. Shi, 1990, In Vitro Cellular & Developmental Biology.

Protective Effect Cellular Damage Culture of by the Serum against Active Oxygen in

M. Kan, T. Ogasawara, 2006 .

Protective effect of the serum against cellular damage by active oxygen in culture.

M. Kan, T. Ogasawara, 1984, The Tohoku journal of experimental medicine.

Release of fibroblast growth factor-1 by human squamous cell carcinoma correlates with autocrine cell growth

M. Kan, Y. Myoken, T. Okamoto, 1994, In Vitro Cellular & Developmental Biology - Animal.

Growth and differentiation of periodontal ligament-derived cells in serum-free defined culture

Yoshiharu Tanaka, M. Kan, T. Okamoto, 1997, In Vitro Cellular & Developmental Biology - Animal.

Identification and assay of fibroblast growth factor receptors.

M. Kan, W. Mckeehan, E. Shi, 1991, Methods in enzymology.

Bifunctional effects of transforming growth factor-β (TGF-β) on endothelial cell growth correlate with phenotypes of TGF-β binding sites

M. Kan, J. Sato, W. Mckeehan, 1990 .

Fibroblast growth factor receptors from liver vary in three structural domains.

M. Kan, W. Mckeehan, P. Adams, 1991, Science.

High and low affinity binding of heparin-binding growth factor to a 130-kDa receptor correlates with stimulation and inhibition of growth of a differentiated human hepatoma cell.

P. Månsson, M. Kan, W. Mckeehan, 1988, The Journal of biological chemistry.

Elevated Cholesterol Metabolism and Bile Acid Synthesis in Mice Lacking Membrane Tyrosine Kinase Receptor FGFR4*

C. Deng, M. Weinstein, R. Jones, 2000, The Journal of Biological Chemistry.

In vitro proliferation and lifespan of human diploid fibroblasts in serum‐free BSA‐containing medium

M. Kan, I. Yamane, M. Kan, 1982, Journal of cellular physiology.

Opposite effects of monokines (interleukin-1 and tumor necrosis factor) on proliferation and heparin-binding (fibroblast) growth factor binding to human aortic endothelial and smooth muscle cells

M. Kan, H. Sawada, Wallace L. Mc Keehan, 1990, In Vitro Cellular & Developmental Biology.

Heparin-dependent fibroblast growth factor activities: effects of defined heparin oligosaccharides.

J. Thompson, R. Linhardt, M. Kan, 1997, European Journal of Cell Biology.

Comparative endocrinology-paracrinology-autocrinology of human adult large vessel endothelial and smooth muscle cells

M. Kan, W. Mckeehan, Jan-Kan Chen, 1988, In Vitro Cellular & Developmental Biology.

A widely expressed transmembrane serine/threonine kinase that does not bind activin, inhibin, transforming growth factor beta, or bone morphogenic factor.

J. Xu, M. Kan, W. Mckeehan, 1993, The Journal of biological chemistry.

Differential growth requirements of serum factors (bovine serum albumin and low density lipoprotein) for normal and transformed human cells in a serum-free culture.

M. Namba, M. Kan, H. Hoshi, 1983, Cell structure and function.

Growth factor assays for normal human hepatocytes and hepatoma cells

M. Kan, H. Hoshi, 1986 .

Growth inhibition by keratinocyte growth factor receptor of human salivary adenocarcinoma cells through induction of differentiation and apoptosis

M. Kan, T. Okamoto, J. Sato, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Hepatocyte growth factor/hepatopoietin A stimulates the growth of rat kidney proximal tubule epithelial cells (RPTE), rat nonparenchymal liver cells, human melanoma cells, mouse keratinocytes and stimulates anchorage-independent growth of SV-40 transformed RPTE.

G. Michalopoulos, R. Zarnegar, M. Kan, 1991, Biochemical and biophysical research communications.

Expression of fibroblast growth factor binding protein HBp17 in normal and tumor cells

Yoshiharu Tanaka, M. Kan, T. Okamoto, 1996, In Vitro Cellular & Developmental Biology - Animal.

Regulation of rat proximal tubule epithelial cell growth by fibroblast growth factors, insulin‐like growth factor‐1 and transforming growth factor‐β, and analysis of fibroblast growth factors in rat kidney

J. Stevens, M. Kan, T. Ichimura, 1991, Journal of cellular physiology.

Heparin-binding fibroblast growth factors and prostate cancer.

M. Kan, W. Mckeehan, P. Adams, 1993, Advances in experimental medicine and biology.

The Nonsense-mediated Decay Pathway and Mutually Exclusive Expression of Alternatively Spliced FGFR2IIIb and -IIIc mRNAs*

Tohru Suzuki, M. Kan, W. Mckeehan, 2001, The Journal of Biological Chemistry.

Androgen-stimulated human prostate epithelial growth mediated by stromal-derived fibroblast growth factor-10.

H. Yamanaka, N. Itoh, M. Kan, 1999, Endocrine journal.

Growth Factor Receptor 1 Complex with Progression-promoting Ectopic Fibroblast Syndecan-1 Forms a Fibroblast Growth Factor-binding A Rare Premalignant Prostate Tumor Epithelial Cell

M. Kan, W. Mckeehan, Chundong Yu, 2001 .

Heparan sulfate fibroblast growth factor receptor complex: Structure‐function relationships

M. Kan, W. Mckeehan, 1994, Molecular reproduction and development.

Fibroblast growth factor receptor-1 is expressed by endothelial progenitor cells.

T. Suda, R. Hebbel, M. Kan, 2002, Blood.

Immunohistochemical localization of fibroblast growth factor-1 (FGF-1), FGF-2 and fibroblast growth factor receptor-1 (FGFR-1) in pleomorphic adenoma of the salivary glands.

M. Kan, Y. Myoken, T. Okamoto, 1997, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

16-kilodalton heparin binding (fibroblast) growth factor type one appears in a stable 40-kilodalton complex after receptor-dependent internalization.

J. Xu, M. Kan, W. Mckeehan, 1991, The Journal of biological chemistry.

High salt inhibits both heparin-dependent and heparin-independent complexes of fibroblast growth factor and the receptor kinase

Xiaochong Wu, M. Kan, W. Mckeehan, 1997, In Vitro Cellular & Developmental Biology - Animal.

Control of fibroblast growth factor receptor kinase signal transduction by heterodimerization of combinatorial splice variants

J. Xu, M. Kan, W. Mckeehan, 1993, Molecular and cellular biology.

Differential expression of transforming growth factor-β and its receptors in hepatocytes and nonparenchymal cells of rat liver after CCl4 administration

K. Matsuzaki, T. Seki, M. Matsushita, 1998 .

Genomic structure and cloned cDNAs predict that four variants in the kinase domain of serine/threonine kinase receptors arise by alternative splicing and poly(A) addition.

J. Xu, M. Kan, W. Mckeehan, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Evidence that the intracellular domain of FGF receptor 2IIIb affects contact of the ectodomain with two FGF7 ligands.

Y. Luo, M. Kan, W. Mckeehan, 2001, Biochemical and biophysical research communications.

IIIb Affects Contact of the Ectodomain ith Two FGF 7 Ligands

M. Kan, W. Mckeehan, Jun-Hyeog Jang, 2001 .

Expression and immunochemical analysis of rat and human fibroblast growth factor receptor (flg) isoforms.

J. Xu, M. Kan, M. Fraser, 1992, The Journal of biological chemistry.

The Effects on Cell Adhesion of Fibronectin and Gelatin in a Serum-Free, Bovine Serum Albumin Medium

M. Kan, M. Umeda, Y. Minamoto, 1982 .

Expression of fibroblast growth factor‐1 (FGF‐1), FGF‐2 and FGF receptor‐1 in a human salivary‐gland adenocarcinoma cell line: Evidence of autocrine growth

M. Kan, Y. Myoken, T. Okamoto, 1996 .

IMMUNOHISTOCHEMICAL STUDY OF OVEREXPRESSION OF FIBROBLAST GROWTH FACTOR‐1 (FGF‐1), FGF‐2, AND FGF RECEPTOR‐1 IN HUMAN MALIGNANT SALIVARY GLAND TUMOURS

M. Kan, Y. Myoken, T. Okamoto, 1996, The Journal of pathology.

α-Cyclodextrin, a Novel Substitute for Bovine Albumin in Serum-Free Culture of Mammalian Cells

M. Kan, I. Yamane, Y. Minamoto, 1981 .

Structural basis for interaction of FGF-1, FGF-2, and FGF-7 with different heparan sulfate motifs.

Y. Luo, R. Linhardt, S. Ye, 2001, Biochemistry.

Primary culture of human diploid cells and its long-term transfer in a serum-free medium.

M. Kan, H. Hoshi, I. Yamane, 1981, Experimental cell research.

Direct analysis of growth factor requirements for isolated human fetal hepatocytes

M. Kan, W. Mckeehan, H. Hoshi, 1987, In Vitro Cellular & Developmental Biology.

Nuclear localization of a complex of fibroblast growth factor(FGF)-1 and an NH2-terminal fragment of FGF receptor isoforms R4 and R1alpha in human liver cells.

J. Xu, M. Kan, W. Mckeehan, 1996, Biochimica et biophysica acta.

Specificity for Fibroblast Growth Factors Determined by Heparan Sulfate in a Binary Complex with the Receptor Kinase*

Xiaochong Wu, M. Kan, W. Mckeehan, 1999, The Journal of Biological Chemistry.

A Homeo-interaction Sequence in the Ectodomain of the Fibroblast Growth Factor Receptor*

M. Kan, W. Mckeehan, Jun-Hyeog Jang, 1997, The Journal of Biological Chemistry.

Molecular Modeling and Deletion Mutagenesis Implicate the Nuclear Translocation Sequence in Structural Integrity of Fibroblast Growth Factor-1*

J. Gabriel, M. Kan, W. Mckeehan, 1996, The Journal of Biological Chemistry.

Ligand-specific Structural Domains in the Fibroblast Growth Factor Receptor (*)

M. Kan, W. Mckeehan, Fen Wang, 1995, The Journal of Biological Chemistry.

Alternately Spliced NH2-terminal Immunoglobulin-like Loop I in the Ectodomain of the Fibroblast Growth Factor (FGF) Receptor 1 Lowers Affinity for both Heparin and FGF-1(*)

M. Kan, W. Mckeehan, Fen Wang, 1995, The Journal of Biological Chemistry.

An essential heparin-binding domain in the fibroblast growth factor receptor kinase.

J. Xu, M. Kan, W. Mckeehan, 1993, Science.

Divalent Cations and Heparin/Heparan Sulfate Cooperate to Control Assembly and Activity of the Fibroblast Growth Factor Receptor Complex*

J. Gabriel, M. Kan, W. Mckeehan, 1996, The Journal of Biological Chemistry.

Patents and literature

W. Thilly, R. Purcell, D. Mears, 1986 .

HYDROCORTISONE POTENTIATES CELL PROLIFERATION AND PROMOTES CELL SPREADING ON TISSUE CULTURE SUBSTRATA OF HUMAN DIPLOID FIBROBLASTS IN A SERUM-FREE HORMONE-SUPPLEMENTED MEDIUM

M. Kan, H. Hoshi, I. Yamane, 1982 .

Directional specificity of prostate stromal to epithelial cell communication via FGF7/FGFR2 is set by cell- and FGFR2 isoform-specific heparan sulfate

Xiaochong Wu, M. Kan, Fen Wang, 2001, In Vitro Cellular & Developmental Biology - Animal.

Vascular endothelial cell growth factor (VEGF) produced by A-431 human epidermoid carcinoma cells and identification of VEGF membrane binding sites.

M. Kan, T. Okamoto, J. Sato, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Effects of extracellular matrices on human keratinocyte adhesion and growth and on its secretion and deposition of fibronectin in culture.

H. Tagami, M. Kan, M. Isemura, 1987, The Journal of investigative dermatology.

The glycine box: a determinant of specificity for fibroblast growth factor.

J. Gabriel, M. Kan, W. Mckeehan, 1998, Biochemistry.

Induction of FGF-7 after kidney damage: a possible paracrine mechanism for tubule repair.

P. Finch, J. Stevens, M. Kan, 1996, The American journal of physiology.

Long-term serial cultivation and growth requirements for human umbilical vein endothelial cells

M. Kan, I. Yamane, Miwakato, 1985, In Vitro Cellular & Developmental Biology.

Inhibition of growth of malignant rat prostate tumor cells by restoration of fibroblast growth factor receptor 2.

A. Matsubara, M. Kan, W. Mckeehan, 1998, Cancer research.

Fibroblast growth factor receptor 2 limits and receptor 1 accelerates tumorigenicity of prostate epithelial cells.

A. Matsubara, M. Kan, W. Mckeehan, 1997, Cancer research.

Ligand binding properties of binary complexes of heparin and immunoglobulin-like modules of FGF receptor 2.

Y. Luo, M. Kan, W. Mckeehan, 2000, Biochemical and biophysical research communications.

Multiple mutant cDNAs from one reaction mixture using asymmetric primers in PCR.

M. Kan, W. Mckeehan, F. Wang, 1995, BioTechniques.

Oxygen-dependent growth declining and effect of vitamin E for human diploid fibroblasts in serum-free, BSA-containing culture.

M. Kan, I. Yamane, 1983, The Tohoku journal of experimental medicine.

Purification and characterization of an endothelial cell growth factor from serum-free culture medium of human diploid fibroblast cells.

M. Kan, T. Satoh, I. Yamane, 1986, Biochimica et biophysica acta.

Characterization of a new endothelial cell growth factor (f-ECGF) partially purified from the supernatant of human fibroblast cells.

M. Obinata, M. Kan, T. Satoh, 1989, Cell structure and function.

Receptor phenotype underlies differential response of hepatocytes and nonparenchymal cells to heparin-binding fibroblast growth factor type 1 (aFGF) and type 2 (bFGF)

Jianming Xu, M. Kan, J. Hou, 1992, In Vitro Cellular & Developmental Biology - Animal.

Analysis of Serine, Threonine and Tyrosine Phosphorylation Sites with Mass Spectrometry

S. Carr, K. Palczewski, M. Huddleston, 1993 .

Constitutive activating mutation of the FGFR3b in oral squamous cell carcinomas

Mikio Kan, M. Kan, T. Okamoto, 2005, International journal of cancer.

Improved recovery of active radiolabeled tgfß1 by tgfß receptor type III affinity chromatography

A. Taniguchi, M. Kan, K. Nakano, 1999, In Vitro Cellular & Developmental Biology - Animal.

Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors.

M. Kan, T. Okamoto, J. Sato, 1991, The Journal of biological chemistry.

Bifunctional effects of transforming growth factor-beta (TGF-beta) on endothelial cell growth correlate with phenotypes of TGF-beta binding sites.

M. Kan, J. Sato, W. Mckeehan, 1990, Experimental cell research.

Heparin-binding (fibroblast) growth factors are potential autocrine regulators of esophageal epithelial cell proliferation

M. Kan, M. Katayama, 1991, In Vitro Cellular & Developmental Biology - Animal.

Heparin-binding (fibroblast) growth factors type one and two genes are co-expressed in proliferating normal human vascular endothelial and smooth muscle cells in culture

P. Månsson, M. Kan, W. Mckeehan, 1990, In Vitro Cellular & Developmental Biology.

Control of Fibroblast Growth Factor (FGF) 7- and FGF1-induced Mitogenesis and Downstream Signaling by Distinct Heparin Octasaccharide Motifs*

S. Ye, M. Kan, W. Mckeehan, 2006, Journal of Biological Chemistry.

Expression of fibroblast growth factor-1 (FGF-1), FGF-2 and FGF receptor-1 in a human salivary-gland adenocarcinoma cell line: evidence of growth.

M. Kan, T. Okamoto, J. Sato, 1996, International journal of cancer.

Erratum: Fibroblast growth factor-10. A second candidate stromal to epithelial cell andromedin in prostate (Journal of Biological Chemistry (1999) 274 (12827-12834))

Weiqin Lu, M. Kan, W. Mckeehan, 1999 .

Androgen-dependent expression of fibroblast growth factor-1 in submaxillary gland of mouse.

Y. Kato, M. Kan, T. Okamoto, 1996, Biochemical and biophysical research communications.

Specific cell types and their requirements

K. Matsuzaki, K. Mills, M. Kan, 1994 .

Phorbol ester reduces number of heparin‐binding growth‐factor receptors in human adult endothelial cells

M. Kan, W. Mckeehan, Jan-Kan Chen, 1988, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Common and specific determinants for fibroblast growth factors in the ectodomain of the receptor kinase complex.

J. Gabriel, M. Kan, W. Mckeehan, 1999, Biochemistry.

Cell Cycle Regulation of Glucocorticoid Binding and Proliferation of Human Diploid Fibroblasts in a Serum-Free Defined Medium

M. Kan, H. Hoshi, I. Yamane, 1982 .

Studies on the biological characterization and mitogenic interactions between hepatic stimulator substance and acidic fibroblast growth factor.

M. Kan, W. Mckeehan, S. Gupta, 1994, Cancer letters.

Heparin-binding (fibroblast) growth factors are potential autocrine regulators of esophageal epithelial cell proliferation.

M. Kan, M. Katayama, 1992, The Tohoku journal of experimental medicine.

Primary culture of human esophageal epithelial cells.

M. Kan, T. Nishihira, I. Yamane, 1984, The Tohoku journal of experimental medicine.

Establishment of six human pancreatic cancer cell lines and their sensitivities to anti-tumor drugs.

M. Kan, S. Matsuno, Toshio Sato, 1986, The Tohoku journal of experimental medicine.

EXPRESSION OF FIBROBLAST GROWTH FACTOR RECEPTOR GENES IN HUMAN HEPATOMA-DERIVED CELL LINES

Yoshiharu Tanaka, K. Chayama, M. Kan, 2007 .

Heparin-Binding (Fibroblast) Growth Factor/Receptor Gene Expression in the Prostate

P. Månsson, M. Kan, W. Mckeehan, 1991 .

IMMUNOHISTOCHEMICAL STUDY OF OVEREXPRESSION OF FIBROBLAST GROWTH FACTOR‐1 (FGF‐1), FGF‐2, AND FGF RECEPTOR‐1 IN HUMAN MALIGNANT SALIVARY GLAND TUMOURS

M. Kan, Y. Myoken, T. Okamoto, 1996, The Journal of pathology.

cis-4-Hydroxy-L-proline and ethyl-3,4-dihydroxybenzoate prevent myogenesis of C2C12 muscle cells and block MyoD1 and myogenin expression.

O. Saitoh, M. Kan, M. Periasamy, 1992, Experimental cell research.

Effects of ferrous iron and transferrin on cell proliferation of human diploid fibroblasts in serum-free culture

M. Kan, I. Yamane, 1984, In Vitro.