A. Lipkowski

发表

A substance P-opioid chimeric peptide as a unique nontolerance-forming analgesic.

J. Marchand, A. Kopin, S. Foran, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Peptides as receptor selectivity modulators of opiate pharmacophores.

A. Lipkowski, S. Tam, P. Portoghese, 1986, Journal of medicinal chemistry.

Kappa-opioid receptors and relapse-like drinking in long-term ethanol-experienced rats

R. Spanagel, S. Hölter, A. Lipkowski, 2000, Psychopharmacology.

Inhibitory effect of biphalin and AZT on murine Friend leukemia virus infection in vitro.

A. Lipkowski, S. Specter, J. Tang, 1998, International journal of immunopharmacology.

Benzomorphan alkaloids: Natural peptidomimetics of opioid peptide pharmacophores

V. Hruby, A. Lipkowski, A. Misicka, 1995, Letters in Peptide Science.

7 – Neuropeptides: Peptide and Nonpeptide Analogs

D. Carr, A. Lipkowski, 1995 .

Stereostructure-activity relationship of opioid agonist and antagonist bivalent ligands. Evidence for bridging between vicinal opioid receptors.

D. L. Larson, K. Rice, A. Lipkowski, 1985, Journal of medicinal chemistry.

Low molecular mass peptide dendrimers that express antimicrobial properties.

A. Lipkowski, Z. Urbańczyk-Lipkowska, J. Janiszewska, 2003, Bioorganic & medicinal chemistry letters.

Blood-to-central nervous system entry and stability of biphalin, a unique double-enkephalin analog, and its halogenated derivatives.

S. Williams, V. Hruby, A. Lipkowski, 1996, The Journal of pharmacology and experimental therapeutics.

Analgesic activity of a novel bivalent opioid peptide compared to morphine via different routes of administration

M. S. Cepeda, B. Silbert, D. Carr, 1991, Agents and Actions.

Rapakinin, Arg–Ile–Tyr, derived from rapeseed napin, shows anti-opioid activity via the prostaglandin IP receptor followed by the cholecystokinin CCK2 receptor in mice

A. Lipkowski, M. Yoshikawa, K. Ohinata, 2011, Peptides.

Rubiscolin, a delta selective opioid peptide derived from plant Rubisco.

A. Lipkowski, Y. Kawamura, M. Yoshikawa, 2001, FEBS letters.

Rubiscolin, a δ selective opioid peptide derived from plant Rubisco

A. Lipkowski, Y. Kawamura, M. Yoshikawa, 2001 .

International Association for the Study of Pain ® Ketamine: Does Life Begin at 40? Pain Clinical Updates Editor-in-chief Fear and Pain Pain and Philosophy Pain from Torture

A. Jadad, D. Carr, A. Lipkowski, 2022 .

Direct antimicrobial properties of substance P.

D. Carr, A. Lipkowski, K. Kowalska, 2002, Life sciences.

Spinal antinociceptive effects of AA501, a novel chimeric peptide with opioid receptor agonist and tachykinin receptor antagonist moieties.

J. Marchand, S. Foran, D. Carr, 2004, European journal of pharmacology.

Modifications of the 4,4'-residues and SAR studies of Biphalin, a highly potent opioid receptor active peptide.

V. Hruby, R. Hughes, B. Lou, 1998, Bioorganic & Medicinal Chemistry Letters.

Use of hydrophilic diamines for bridging of two opioid peptide pharmacophores. Synthesis and receptor binding of two new analogues.

J. Stȩpiński, A. Lipkowski, A. Temeriusz, 2009, International journal of peptide and protein research.

Peptide analog of fibronectin that inhibits cell migration and ERK 1/2 activity

J. Ostrowski, A. Lipkowski, A. Misicka, 2001, Peptides.

Assessment of an in vitro blood-brain barrier model using several [Met5]enkephalin opioid analogs.

V. Hruby, A. Lipkowski, A. Misicka, 1993, The Journal of pharmacology and experimental therapeutics.

Cardiorespiratory action of opioid/tachykinin agonist peptide hybrid in anaesthetized rats: Transduction pathways

A. Lipkowski, M. Szereda‐Przestaszewska, Piotr Wojciechowski, 2017, European journal of pharmacology.

Molecular Antioxidant Properties and In Vitro Cell Toxicity of the p-Aminobenzoic Acid (PABA) Functionalized Peptide Dendrimers

A. Lipkowski, Maja Morawiak, Z. Urbańczyk-Lipkowska, 2019, Biomolecules.

Opioid agonist and antagonist activities of peripherally selective derivatives of naltrexamine and oxymorphamine.

D. L. Larson, Peter A. Stark, A. Lipkowski, 1989, Journal of medicinal chemistry.

Synthesis and formulation for biological study of the β-amyloid(1–42) polypeptide

M. Barcikowska, A. Lipkowski, A. Misicka, 1995 .

Binaltorphimine and nor-binaltorphimine, potent and selective kappa-opioid receptor antagonists.

A. Lipkowski, P. Portoghese, A. Takemori, 1987, Life sciences.

In vitro pharmacological evaluation of the radiolabeled C-terminal substance P analogue Lys-Phe-Phe-Gly-Leu-Met-NH2: Does a specific binding site exist?

A. Lipkowski, A. Misicka, A. Keresztes, 2014, Folia neuropathologica.

Enhanced potency of intravenous, but not intrathecal, morphine and morphine-6-glucuronide after burn trauma.

B. Silbert, D. Carr, A. Lipkowski, 1994, Life sciences.

TAPP analogs containing β3‐homo‐amino acids: synthesis and receptor binding

A. Lipkowski, P. Kosson, A. Olma, 2012, Journal of peptide science : an official publication of the European Peptide Society.

New antihypertensive peptides isolated from rapeseed

A. Lipkowski, H. Fujita, M. Yoshikawa, 2003, Peptides.

Arg-Ile-Tyr (RIY) derived from rapeseed protein decreases food intake and gastric emptying after oral administration in mice

A. Lipkowski, M. Yoshikawa, K. Ohinata, 2006, Peptides.

Anti-inflammatory and antinociceptive action of the dimeric enkephalin peptide biphalin in the mouse model of colitis: New potential treatment of abdominal pain associated with inflammatory bowel diseases

J. Fichna, A. Lipkowski, M. Sobczak, 2014, Peptides.

Binaltorphimine-related bivalent ligands and their kappa opioid receptor antagonist selectivity.

D. L. Larson, A. Lipkowski, P. Portoghese, 1988, Journal of medicinal chemistry.

The biological consequences of replacing hydrophobic amino acids in deltorphin I with amphiphilic alpha-hydroxymethylamino acids.

A. Lipkowski, A. Olma, M. Łachwa, 2003, The journal of peptide research : official journal of the American Peptide Society.

Biphalin analogs containing β3-homo-amino acids at the 4,4′ positions: Synthesis and opioid activity profiles

A. Lipkowski, P. Kosson, A. Olma, 2015, Peptides.

Interaction of a highly potent dimeric enkephalin analog, biphalin, with model membranes.

V. Hruby, A. Lipkowski, A. Misicka, 1997, Biochimica et biophysica acta.

Structure-activity relationship of biphalin. The synthesis and biological activities of new analogues with modifications in positions 3 and 4.

R. Horváth, V. Hruby, A. Lipkowski, 1997, Life sciences.

6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid mimics active conformation of tyrosine in opioid peptides.

D. Carr, A. Lipkowski, P. Kosson, 2005, Bioorganic & medicinal chemistry letters.

Opioid and neurokinin activities of substance P fragments and their analogs.

A. Lipkowski, G. Wilcox, S. Lei, 1991, European journal of pharmacology.

Agonist and antagonist profiles of [D-Ala2,Glu4]deltorphin and its [Cys4]- and [Ser4]-substituted derivatives: further evidence of opioid delta receptor multiplicity.

V. Hruby, A. Lipkowski, A. Misicka, 1993, The Journal of pharmacology and experimental therapeutics.

Synthesis and biological properties of gamma-glutamyl-dermorphin, a prodrug.

V. Hruby, A. Lipkowski, I. Maszczyńska, 1996, Life sciences.

Alternative forms of interaction of substance P and opioids in nociceptive transmission

D. Carr, A. Lipkowski, I. Maszczyńska, 1998, Letters in Peptide Science.

Advances in analgesic drug design and delivery: a current survey.

V. Hasırcı, D. Carr, A. Lipkowski, 2004, Advances in experimental medicine and biology.

Inhibition of morphine tolerance development by a substance P-opioid peptide chimera.

J. Marchand, A. Kopin, S. Foran, 2000, The Journal of pharmacology and experimental therapeutics.

Spinal co-administration of peptide substance P antagonist increases antinociceptive effect of the opioid peptide biphalin.

D. Carr, A. Lipkowski, I. Maszczyńska, 1994, Life sciences.

Cardiorespiratory activity of C-terminal pentapeptide of substance P in anaesthetized rats

A. Lipkowski, M. Szereda‐Przestaszewska, Piotr Wojciechowski, 2016, Respiratory Physiology & Neurobiology.

An approach to the self regulatory mechanism of substance P actions: II. Biological activity of new synthetic peptide analogs related both to enkephalin and substance P.

A. Lipkowski, W. Gumułka, B. Osipiak, 1983, Life sciences.

The non-opioid receptor, antioxidant properties of morphine and the opioid peptide analog biphalin

A. Lipkowski, B. Zabłocka, A. Gulea, 2015, Peptides.

The opioid peptide analogue biphalin induces less physical dependence than morphine.

A. Lipkowski, A. Lipkowski, M. Narita, 2001, Life sciences.

[125I-Tyr1]biphalin binding to opioid receptors of rat brain and NG108-15 cell membranes.

S. Appleyard, V. Hruby, R. Knapp, 1998, Life sciences.

Non-deterministic individual responses to receptor-selective opioid agonists.

B. Silbert, D. Carr, A. Lipkowski, 1994, Polish journal of pharmacology.

Bivalent opioid peptide analogues with reduced distances between pharmacophores.

A. Lipkowski, S. Tam, A. Konecka, 1987, Life sciences.

Enkephalin analog prodrugs: assessment of in vitro conversion, enzyme cleavage characterization and blood-brain barrier permeability.

V. Hruby, A. Lipkowski, A. Misicka, 1996, The Journal of pharmacology and experimental therapeutics.

Kappa-opioid receptor-mediated antinociception in the rat. II. Supraspinal in addition to spinal sites of action.

A. Lipkowski, A. Herz, M. Millan, 1989, The Journal of pharmacology and experimental therapeutics.

Pseudoirreversible binding characteristics of [D-Ala2,Glu4]deltorphin and its Cys4 substituted derivative to delta-opioid receptors.

V. Hruby, A. Lipkowski, A. Misicka, 1993, European journal of pharmacology.

Topographical requirements for delta opioid ligands: presence of a carboxyl group in position 4 is not critical for deltorphin high delta receptor affinity and analgesic activity.

V. Hruby, T. Burks, R. Knapp, 1991, Biochemical and biophysical research communications.

Design of cyclic deltorphins and dermenkephalins with a disulfide bridge leads to analogues with high selectivity for delta-opioid receptors.

V J Hruby, R. Horváth, V. Hruby, 1994, Journal of medicinal chemistry.

OPIOID PEPTIDE ANALOGUES : RECONSIDERATION AS A POTENTIALLY NEW GENERATIONOF ANALGESICS

V. Hruby, D. Carr, A. Lipkowski, 1994 .

Local increases of subcutaneous beta-endorphin immunoactivity at the site of thermal injury.

D. Carr, A. Lipkowski, K. Hargreaves, 1993, Immunopharmacology.

Mixed MOP/DOP agonist biphalin elicits anti-transit effect in mouse models mimicking diarrhea-predominant irritable bowel syndrome symptoms

J. Fichna, A. Lipkowski, M. Sałaga, 2016, Pharmacological reports : PR.

Bimorphinans as highly selective, potent kappa opioid receptor antagonists.

A. Lipkowski, A. Takemori, A. Portoghese, 1987, Journal of medicinal chemistry.

Biphalin: A Multireceptor Opioid Ligand

D. Carr, A. Lipkowski, A. Misicka, 2003 .

Molecular assessment of the potential combination therapy of cytokines with biphalin and AZT for Friend leukemia virus infection in vitro.

A. Lipkowski, S. Specter, Jie Tang, 2008, Pharmacological reports : PR.

Effect of guanidino modification and proline substitution on the in vitro stability and blood-brain barrier permeability of endomorphin II.

A. Lipkowski, A. Misicka, J. Huber, 2002, Journal of pharmaceutical sciences.

Biological activity of fragments and analogues of the potent dimeric opioid peptide, biphalin.

V. Hruby, A. Lipkowski, A. Misicka, 1999, Bioorganic & medicinal chemistry letters.

Morphine-3-glucuronide: silent regulator of morphine actions.

D. Carr, A. Lipkowski, S. Szyfelbein, 1994, Life sciences.

Antinociceptive effects of hydromorphone, bupivacaine and biphalin released from PLGA polymer after intrathecal implantation in rats.

D. Wise, V. Hasırcı, D. Carr, 2003, Biomaterials.

Neuropeptide mimetics for pain management

D. Kosson, A. Lipkowski, A. Misicka, 2004 .

Selective kappa antagonist properties of nor-binaltorphimine in the rat MES seizure model.

J. Holaday, F. Tortella, A. Lipkowski, 1989, Life sciences.

Specialist dysmenorrhea Pain and Quality of life What does Pain Hurt ? Chronic Pain in Survivors of Torture

E. Eisenberg, J. Ballantyne, A. Lipkowski, 2022 .

A novel fibronectin‐related structural motif that modulates cell migration

A. Lipkowski, P. Janik, H. Trembacz, 2008 .

In vitro anti-cancer properties of natural vs synthetic conjugated linoleic acid

J. Kwiatkowski, A. Lipkowski, J. Wietrzyk, 2003 .

Binary drugs: conjugates of purines and a peptide that bind to both adenosine and substance P receptors.

K. Jacobson, T. Moody, J. Daly, 1987, Journal of medicinal chemistry.

Bioinspired Amphiphilic Peptide Dendrimers as Specific and Effective Compounds against Drug Resistant Clinical Isolates of E. coli.

A. Lipkowski, J. Solecka, Z. Urbańczyk-Lipkowska, 2018, Bioconjugate chemistry.

A topographical model of μ‐opioid and brain somatostatin receptor selective ligands NMR and molecular dynamics studies

V. Hruby, A. Lipkowski, R. Ferguson, 2009 .

Bimorphinans as Highly Selective, Potent K Opioid Receptor Antagonists.

A. Lipkowski, P. Portoghese, A. Takemori, 1987 .

Angiotensin AT2 receptor agonists act as anti-opioids via EP3 receptor in mice

A. Lipkowski, M. Yoshikawa, Yuko Yamada, 2009, Peptides.

Endomorphins interact with tachykinin receptors

D. Carr, A. Lipkowski, P. Kosson, 2005, Peptides.

Analogues of deltorphin I containing conformationally restricted amino acids in position 2: structure and opioid activity

A. Lipkowski, A. Olma, A. Ejchart, 2015, Journal of peptide science : an official publication of the European Peptide Society.

In vivo antinociception of potent mu opioid agonist tetrapeptide analogues and comparison with a compact opioid agonist - neurokinin 1 receptor antagonist chimera

A. Lipkowski, P. Kosson, P. Schiller, 2012, Molecular Brain.

Alternative Forms of Interaction of Substance P and Opioids in Nociceptive Transmission

D. Carr, A. Lipkowski, I. Maszczyńska, 2004, Letters in Peptide Science.

Enterostatin (VPDPR) Has Anti-analgesic and Anti-amnesic Activites

A. Lipkowski, Y. Takenaka, M. Yoshikawa, 2001, Bioscience, biotechnology, and biochemistry.

Anti-analgesic activity of enterostatin (VPDPR) is mediated by corticosterone

A. Lipkowski, Y. Takenaka, M. Yoshikawa, 2003, Peptides.

Rapakinin, an anti-hypertensive peptide derived from rapeseed protein, dilates mesenteric artery of spontaneously hypertensive rats via the prostaglandin IP receptor followed by CCK1 receptor

Masashi Iwasaki, A. Lipkowski, M. Yoshikawa, 2010, Peptides.

The effect of enkephalin dimers on body temperature in mice

A. Lipkowski, A. Konecka, I. Sroczyńska, 1987, Peptides.

Is RNA-laden p24 capsid protein a vector for HIV?

V. Hruby, D. Carr, A. Lipkowski, 2004, Medical hypotheses.

Crystal structure of biphalin sulfate: a multireceptor opioid peptide.

J. Deschamps, C. George, J. Flippen-Anderson, 2002, The journal of peptide research : official journal of the American Peptide Society.

Effect of peptide conformation on membrane permeability.

V. Hruby, A. Lipkowski, A. Misicka, 2003, The journal of peptide research : official journal of the American Peptide Society.

Kyotorphin and d-kyotorphin stimulate Met-enkephalin release from rat striatum in vitro

A. Lipkowski, P. Janicki, 1983, Neuroscience Letters.

Cross interaction of β-amyloid peptide and prion protein fragments

A. Lipkowski, A. Misicka, Lukasz P. Frankiewicz, 2002, Letters in Peptide Science.

Topographical requirements for delta opioid ligands: common structural features of dermenkephalin and deltorphin.

R. Horváth, V. Hruby, A. Lipkowski, 1992, Life sciences.

Document Specialist Fear and Pain Pain in Women Pain from torture

E. Eisenberg, D. Carr, A. Lipkowski, 2022 .

Delta opioid receptor selective ligands; DPLPE-deltorphin chimeric peptide analogues.

R. Horváth, V. Hruby, A. Lipkowski, 2009, International journal of peptide and protein research.

The synthesis and opioid receptor binding affinities of analogues of dermorphin and its N-terminal tetrapeptide fragment with dibasic acids in position 2.

V. Hruby, A. Lipkowski, A. Misicka, 1995, Life sciences.

The synthesis and opioid receptor binding affinities of dermorphin and deltorphin analogs with dibasic amino acids in position 2

R. Horváth, V. Hruby, A. Lipkowski, 1993 .

Topographical requirements for delta opioid ligands: The synthesis and biological properties of a cyclic analogue of deltorphin I

R. Horváth, V. Hruby, G. Nikiforovich, 1992 .

Topographical requirements for δ opioid ligands: The synthesis and biological properties of cyclic analogues of deltorphins and dermenkephalin

R. Horváth, V. Hruby, A. Lipkowski, 1993 .

Supranodose vagotomy eliminates respiratory depression evoked by dermorphin in anaesthetized rats.

A. Lipkowski, M. Szereda‐Przestaszewska, Piotr Wojciechowski, 2007, European journal of pharmacology.

Topographic model of delta opioid selective ligands; DPLPE-deltorphin hybrid analogues

R. Horváth, V. Hruby, A. Lipkowski, 1994, Regulatory Peptides.

Amino acids with amphiphilic side chains: Deltorphin analogues with Phe3 replaced by all β-hydroxyphenylalanine diastereoisomers

V. Hruby, A. Lipkowski, A. Misicka, 1995, Letters in Peptide Science.

Effects of endomorphin-2 on arterial blood pressure and pain threshold in spontaneously hypertensive rats and modification of these effects by beta-funaltrexamine and nor-binaltorphimine.

A. Lipkowski, H. Makulska-Nowak, S. Gumułka, 2001, Life sciences.

Anticancer Properties of Peptide Fragments of Hair Proteins

A. Lipkowski, Joanna Matalińska, K. Kurzepa, 2014, PloS one.

Studies on conjugated linoleic acid (CLA) in sheep milk fat

J. Kwiatkowski, A. Lipkowski, B. Patkowska-Sokoła, 2001 .

The process of isomerisation of plant oils rich in linoleic acid aimed at obtaining linoleic acid isomers (CLA)

A. Lipkowski, M. Janczak, B. Patkowska-Sokoła, 2008 .

Cardiorespiratory effects of opioid and tachykinin pharmacophores chemically linked or separate in anesthetized rats

A. Lipkowski, M. Szereda‐Przestaszewska, Piotr Wojciechowski, 2011 .

Delta opioid receptors contribute to the cardiorespiratory effects of biphalin in anesthetized rats

A. Lipkowski, M. Szereda‐Przestaszewska, Piotr Wojciechowski, 2011, Pharmacological reports : PR.

Transfer of fatty acyl groups from membrane phosphatides to opiate ligands

D. L. Larson, A. Lipkowski, P. Portoghese, 1989, Neurochemistry International.

Neuropeptides and pain.

D. Carr, A. Lipkowski, 1990, Agressologie: revue internationale de physio-biologie et de pharmacologie appliquees aux effets de l'agression.

Biological properties of a new fluorescent biphalin fragment analogue.

V. Hruby, D. Kosson, A. Lipkowski, 2002, Life Science.

Binding of SPXK- and APXK-peptide motifs to AT-rich DNA. Experimental and theoretical studies.

A. Jerzmanowski, A. Lipkowski, B. Lesyng, 1998, Acta biochimica Polonica.

Enhanced Potency of Receptor‐Selective Opioids After Acute Burn Injury

B. Silbert, A. Lipkowski, Daniel B. Carr, 1991, Anesthesia and analgesia.

Peptide, N-methyl-D-aspartate and adenosine receptors as analgesic targets

A. Lipkowski, I. Maszczyńska, 1996 .

The structure of N,N′-di-l-phenylalanine hydrazide determined by X-ray diffraction methods

A. Lipkowski, G. Argay, P. Gluziński, 1986 .

Delta opioid receptors contribute to the cardiorespiratory effects of biphalin in anesthetized rats

A. Lipkowski, M. Szereda‐Przestaszewska, Piotr Wojciechowski, 2011, Pharmacological reports : PR.

Respiratory and cardiovascular effects of biphalin in anaesthetized rats.

A. Lipkowski, M. Szereda‐Przestaszewska, Piotr Wojciechowski, 2009, European journal of pharmacology.