M. Threadgill

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Synthesis and characterisation of polyamine-poly(ethylene glycol) constructs for DNA binding and gene delivery.

C. Pouton, D. Milroy, S. Garrett, 2000, Bioorganic & medicinal chemistry.

Heterocyclic analogues of L-citrulline as inhibitors of the isoforms of nitric oxide synthase (NOS) and identification of N(delta)-(4,5-dihydrothiazol-2-yl)ornithine as a potent inhibitor.

E. Chinje, I. Stratford, M. Jaffar, 1999, Bioorganic & medicinal chemistry.

Design and Discovery of 2-Arylquinazolin-4-ones as Potent and Selective Inhibitors of Tankyrases.

M. D. Lloyd, P. Wood, M. Threadgill, 2013, ACS medicinal chemistry letters.

Structure-based design, synthesis and evaluation in vitro of arylnaphthyridinones, arylpyridopyrimidinones and their tetrahydro derivatives as inhibitors of the tankyrases.

M. D. Lloyd, P. Wood, M. Threadgill, 2015, Bioorganic & medicinal chemistry.

Labelled compounds of interest as antitumour agents. Part 41. Deuteration and tritiation of a nitroimidazole‐carborane designed for BNCT

M. Threadgill, M. Scobie, S. Bew, 1994 .

Structure-based design, synthesis and preliminary evaluation of selective inhibitors of dihydrofolate reductase from Mycobacterium tuberculosis.

M. Threadgill, M. H. El-Hamamsy, A. Thompson, 2007, Bioorganic & medicinal chemistry.

Analysis of cocaine, benzoylecgonine, ecgonine methyl ester, ethylcocaine and norcocaine in human urine using HPLC with post-column ion-pair extraction and fluorescence detection.

G. H. Dewar, M. Threadgill, T. Jefferies, 1992, Journal of pharmaceutical and biomedical analysis.

Uptake and retention of nitroimidazole-carboranes designed for boron neutron capture therapy in experimental murine tumours: detection by 11B magnetic resonance spectroscopy.

P. Wood, M. Threadgill, M. Scobie, 1996, International journal of radiation biology.

Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro.

M. D. Lloyd, P. Wood, M. Threadgill, 2015, Bioorganic & medicinal chemistry.

Synthesis of 3-substituted benzamides and 5-substituted isoquinolin-1(2H)-ones and preliminary evaluation as inhibitors of poly(ADP-ribose)polymerase (PARP).

M. Threadgill, W. Whish, C. Y. Watson, 1998, Bioorganic & medicinal chemistry.

Racemases and epimerases operating through a 1,1-proton transfer mechanism: reactivity, mechanism and inhibition

M. D. Lloyd, Timothy J. Woodman, M. Threadgill, 2021, Chemical Society reviews.

Studies on the reductively triggered release of heterocyclic and steroid drugs from 5-nitrothien-2-ylmethyl prodrugs

D. Naughton, M. Threadgill, Sandra Ferrer, 2003 .

2-nitroimidazol-5-ylmethyl as a potential bioreductively activated prodrug system: reductively triggered release of the PARP inhibitor 5-bromoisoquinolinone.

D. Naughton, M. Threadgill, W. Whish, 1999, Bioorganic & medicinal chemistry letters.

5-Nitrofuran-2-ylmethyl group as a potential bioreductively activatedpro-drug system

M. Threadgill, W. Whish, C. Y. Watson, 1997 .

The chemistry of azolotetrazinones

M. Threadgill, 1990 .

Applications of tandem mass spectrometry to the characterization of derivatized glutathione conjugates. Studies with S-(N-methylcarbamoyl)glutathione, a metabolite of the antineoplastic agent N-methylformamide.

T. Baillie, W. Howald, M. Threadgill, 1988, Biomedical & environmental mass spectrometry.

Poly(ADP-ribose)polymerase inhibition - where now?

M. Threadgill, E. Woon, 2005, Current medicinal chemistry.

An investigation of the relationship between the hepatotoxicity and the metabolism of N-alkylformamides.

A. Gescher, M. Threadgill, P. Farmer, 1987, The Journal of pharmacology and experimental therapeutics.

Metabolism of N-methylformamide in mice: primary kinetic deuterium isotope effect and identification of S-(N-methylcarbamoyl)glutathione as a metabolite.

T. Baillie, A. Gescher, M. Threadgill, 1987, The Journal of pharmacology and experimental therapeutics.

Inhibition of nitric oxide (NO.) production in murine macrophages by flavones.

W. Krol, M. Threadgill, Z. Czuba, 1995, Biochemical pharmacology.

Synthesis and biological evaluation of a series of flavones designed as inhibitors of protein tyrosine kinases.

P. Groundwater, J. Hickman, I. Dale, 1992, Anti-cancer drug design.

5-Aminoisoquinolin-1-one (5-AIQ), a Water-Soluble Inhibitor of the Poly(ADP-Ribose)Polymerases (PARPs).

M. Threadgill, 2015, Current medicinal chemistry.

5-Benzamidoisoquinolin-1-ones and 5-(ω-carboxyalkyl)isoquinolin-1-ones as isoform-selective inhibitors of poly(ADP-ribose) polymerase 2 (PARP-2).

M. D. Lloyd, P. Wood, M. Threadgill, 2011, Journal of medicinal chemistry.

Relationship between the melanin content of a human melanoma cell line and its radiosensitivity and uptake of pimonidazole

I. Stratford, M. Threadgill, M. Prade, 2004, Cancer Chemotherapy and Pharmacology.

Labelled compounds of interest as antitumour agents. Part II (1). Synthesis of 2H and 3H isotopomers of RSU 1069 and Ro 03-8799 (pimonidazole)

P. Webb, M. Threadgill, 1990 .

Synthesis of N-benzyl- and N-phenyl-2-amino-4,5-dihydrothiazoles and thioureas and evaluation as modulators of the isoforms of nitric oxide synthase.

E. Chinje, I. Stratford, M. Jaffar, 2003, Bioorganic & medicinal chemistry.

Poly(ADP-ribosylation) as target for cancer chemotherapy

I. Judson, M. Threadgill, 1993, The Lancet.

Inhibition of Poly(ADP-Ribose)Polymerase (PARP)

M. Threadgill, 1997 .

Synthesis of porphyrin α,ω-bis(methylamino)peptide constructs

C. Pouton, S. E. Matthews, M. Threadgill, 1999 .

Time-dependence and preliminary SAR studies in inhibition of nitric oxide synthase isoforms by homologues of thiocitrulline.

E. Chinje, I. Stratford, M. Jaffar, 2003, Bioorganic & medicinal chemistry letters.

Monofunctional Electrophilic and Nucleophilic Derivatives of Meso-Tetraphenylporphyrin for Attachment to Peptides: Journal of the Chemical Society-Chemical Communications

C. Pouton, S. E. Matthews, M. Threadgill, 1996 .

Cyclisation of a Substituted N-Acetylserine to A 2-Methyldihydrooxazole With Dimethylaminosulphur Trifluoride

M. Threadgill, N. Devi, Saul J. B. Tendier, 1988 .

Hepatotoxicity of N-methylformamide in mice--II. Covalent binding of metabolites of [14C]-labelled N-methylformamide to hepatic proteins.

A. Gescher, M. Threadgill, P. Pearson, 1987, Biochemical pharmacology.

Differences between rodents and humans in the metabolic toxification of N,N-dimethylformamide.

A. Gescher, M. Threadgill, J. Mráz, 1989, Toxicology and applied pharmacology.

Structure-activity relationships of rationally designed AMACR 1A inhibitors.

M. D. Lloyd, Timothy J. Woodman, M. Threadgill, 2018, Bioorganic chemistry.

Synthesis of thiophenecarboxamides, thieno[3,4-c]pyridin-4(5H)-ones and thieno[3,4-d]pyrimidin-4(3H)-ones and preliminary evaluation as inhibitors of poly(ADP-ribose)polymerase (PARP).

M. Threadgill, W. Whish, A. Shinkwin, 1999, Bioorganic & medicinal chemistry.

Identification of novel small-molecule inhibitors of α-methylacyl-CoA racemase (AMACR; P504S) and structure-activity relationships.

M. D. Lloyd, M. Threadgill, T. James, 2019, Bioorganic chemistry.

One-pot tandem Hurtley-retro-Claisen-cyclisation reactions in the synthesis of 3-substituted analogues of 5-aminoisoquinolin-1-one (5-AIQ), a water-soluble inhibitor of PARPs.

M. D. Lloyd, M. Threadgill, A. Thompson, 2013, Bioorganic & medicinal chemistry.

Reaction of hydrazinoquinolines with trifluoromethyl-β-diketones: structural and mechanistic studies

M. Threadgill, Shiv P. Singh, Devinder Kumar, 1997 .

Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhibitor.

M. D. Lloyd, M. Threadgill, M. Mahon, 2009, Journal of medicinal chemistry.

Structural studies on bio-active compounds. Part 12. Tautomerism and conformation of aryl-substituted 1-(2-hydroxyphenyl)-3-phenylpropane-1,3-diones in the solid phase and in solution

M. Threadgill, P. Lowe, B. D. Cunningham, 1989 .

A biodegradable multiblock co-polymer derived from an α,ω-bis(methylamino)peptide and an α,ω-bis(oxiranylmethyl)poly(ethylene glycol)

C. Pouton, S. E. Matthews, M. Threadgill, 2000 .

5-Nitroisocoumarins from tandem Castro–Stephens coupling—6-endo-dig cyclisation of 2-iodo-3-nitrobenzoic acid and arylethynes and ring-closure of methyl 2-alkynyl-3-nitrobenzoates with electrophiles

M. Threadgill, M. Mahon, E. Woon, 2006 .

Labelled compounds of interest as antitumour agents - VIII. Synthesis of 2H-isotopomers of pentamethylmelamine and of a potential prodrug thereof

D. Naughton, M. Threadgill, Sandra Ferrer, 2002 .

4-Substituted 5-nitroisoquinolin-1-ones from intramolecular Pd-catalysed reaction of N-(2-alkenyl)-2-halo-3-nitrobenzamides

M. D. Lloyd, M. Threadgill, M. Mahon, 2009 .

N3-alkylation during formation of quinazolin-4-ones from condensation of anthranilamides and orthoamides.

M. D. Lloyd, M. Threadgill, A. Thompson, 2011, Organic & biomolecular chemistry.

S-2-amino-5-azolylpentanoic acids related to L-ornithine as inhibitors of the isoforms of nitric oxide synthase (NOS).

E. Chinje, I. Stratford, M. Jaffar, 1998, Bioorganic & medicinal chemistry.

Formation and dehydration of a series of 5-hydroxy-5-trifluoromethyl-4,5-dihydropyrazoles

M. Threadgill, Shiv P. Singh, Dalip Kumar, 1999 .

Structural studies on bioactive compounds. 4. A structure-antitumor activity study on analogues of N-methylformamide.

J. Hickman, M. Stevens, S. Langdon, 1986, Journal of medicinal chemistry.

The reaction of 1,1,1,5,5,5-hexafluoropentane-2,4-dione with hydrazines: a re-investigation

M. Threadgill, Brian G. Jones, A. K. Heer, 1993 .

Synthesis and conformational and configurational studies of diastereoisomeric O-protected 4-(arylsulfonimidoyl)butane-1,2,3-triols

M. D. Lloyd, M. Threadgill, M. Mahon, 2007 .

An expedient synthesis of 7-O-functionalised pyrrolo[2,1-c][1,4]benzodiazepine-5,11-diones

M. Threadgill, A. Thompson, H. Madani, 2002 .

Direct Cu(I)-catalysed coupling of a carborane to a meso-tetraphenylporphyrin

M. Threadgill, M. Mahon, A. Thompson, 2002 .

Tumour-targetted boranes. Part 2. Coupling of closo-carboranes to substituted 2-nitroimidazoles via 1,3-dipolar cycloaddition

M. Threadgill, M. Scobie, M. Mahon, 1994 .

Initial development of a cytotoxic amino-seco-CBI warhead for delivery by prodrug systems.

M. D. Lloyd, P. Wood, M. Threadgill, 2015, Bioorganic & medicinal chemistry.

Identification of 3'-methoxy-4'-nitroflavone as a pure aryl hydrocarbon (Ah) receptor antagonist and evidence for more than one form of the nuclear Ah receptor in MCF-7 human breast cancer cells.

S. Safe, M. Threadgill, M. Santostefano, 1995, Archives of biochemistry and biophysics.

Synthesis of a series of trifluoromethylazoles and determination of pKa of acidic and basic trifluoromethyl heterocycles by 19F NMR spectroscopy

M. Threadgill, A. Thompson, S. Branch, 1996 .

S-2-Amino-4-cyanobutanoic acid (β-cyanomethyl-l-Ala) as an atom-efficient solubilising synthon for l-glutamine

M. D. Lloyd, M. Threadgill, Anne Beauchard, 2011 .

The formation and metabolism of N-hydroxymethyl compounds. Part 8. The oxidative decarboxylation of N-aroylglycines to N-(acetoxymethyl)benzamides and N-formylbenzamides with lead(IV) acetate

M. Threadgill, A. Gledhill, C. McCall, 1986 .

1H and 13C NMR spectra of the rotational isomers of N‐hydroxymethylamides and derivatives

M. Stevens, M. Threadgill, E. Gate, 1985 .

Labelled compounds of interest as antitumour agents‐VII1. [2H]‐ and [14C]‐curcumin

M. Threadgill, I. Parveen, 2000 .

The formation and metabolism of N-hydroxymethyl compounds. Part 6. The synthesis of S-amidomethyl-, S-ureidomethyl-, and S-(1,3,5-triazin-2-ylaminomethyl)-glutathione derivatives

M. Threadgill, P. Shah, E. Gate, 1985 .

Synthesis and evaluation of alpha-[[(2-haloethyl)amino]methyl]-2- nitro-1H-imidazole-1-ethanols as prodrugs of alpha-[(1-aziridinyl)methyl]-2- nitro-1H-imidazole-1-ethanol (RSU-1069) and its analogues which are radiosensitizers and bioreductively activated cytotoxins.

G. Adams, I. Stratford, M. Threadgill, 1990, Journal of medicinal chemistry.

Derivatives of a PARP Inhibitor TIQ-A through the Synthesis of 8-Alkoxythieno[2,3-c]isoquinolin-5(4H)-ones

M. Threadgill, Juha Heiskanen, L. Lehtiö, 2020, ACS omega.

Labelled compounds of interest as antitumour agents ‐ V. Syntheses of [18O]‐5‐methylisoquinolinone and 1‐(furan‐2‐yl‐[18O]‐methoxy)‐5‐methylisoquinoline: Correction (J. Labelled Cpd Radiopharm.38: 935)

M. Threadgill, J. Berry, 1997 .

STRUCTURAL STUDIES ON BIO-ACTIVE COMPOUNDS. PART 2. THE SOLID-STATE AND SOLUTION CONFORMATIONS OF N-METHYL-2-NITROETHENAMINE AND RELATED COMPOUNDS

M. Stevens, M. Threadgill, C. Schwalbe, 1985 .

Tumor-Targeted Boranes. 4. Synthesis of Nitroimidazole-Carboranes with Polyether-Isoxazole Links

M. Threadgill, M. Scobie, 1994 .

Closo --> nido cage degradation of 1-(substituted-phenyl)-1,2-dicarbadodecaborane(12)s in wet DMSO under neutral conditions

C. Powell, M. Threadgill, A. Thompson, 2007 .

Synthesis of meso-substituted porphyrins carrying carboranes and oligo(ethylene glycol) units for potential applications in boron neutron capture therapy.

M. Threadgill, M. Mahon, A. Thompson, 2003, Organic & biomolecular chemistry.

Labelled compounds of interest as antitumour agents ‐ VI 1. Isotopically efficient syntheses of [15N]‐nitrothiophenecarboxamides

M. Threadgill, A. Shinkwin, 1996 .

Formation of a remarkably robust 2:1 complex between beta-cyclodextrin and a phenyl-substituted icosahedral carborane.

M. Threadgill, M. Scobie, A. Thompson, 2002, Chemical communications.

Synthesis of a series of nitrothiophenes with basic or electrophilic substituents and evaluation as radiosensitizers and as bioreductively activated cytotoxins.

P. Webb, G. Adams, I. Stratford, 1991, Journal of medicinal chemistry.

Synthesis and evaluation of novel electrophilic nitrofuran carboxamides and carboxylates as radiosensitizers and bioreductively activated cytotoxins.

G. Adams, I. Stratford, M. Threadgill, 1990, Journal of medicinal chemistry.

Tumour-targetted boranes. Part 3. Synthesis of carbamate-linked nitroimidazolyl carboranes designed for boron neutron capture therapy of cancer

M. Threadgill, M. Scobie, 1994 .

Synthesis of carborane-containing nitroimidazole compounds via mild 1,3-dipolar cycloadition

M. Threadgill, M. Scobie, 1992 .

Synthetic approaches to peptides containing the L-Gln-L-Val-D(S)-Dmt motif.

M. Threadgill, T. Arafat, G. Suaifan, 2007, Bioorganic & medicinal chemistry.

A novel colorimetric assay for α-methylacyl-CoA racemase 1A (AMACR; P504S) utilizing the elimination of 2,4-dinitrophenolate.

M. D. Lloyd, Timothy J. Woodman, M. Threadgill, 2017, Chemical communications.

Labelled compounds of interest as antitumour agents I: N-methylformamide and N, N-dimethylformamide

M. Threadgill, E. Gate, 1983 .

Characterisation of recombinant human fatty aldehyde dehydrogenase: Implications for Sjögren-Larsson syndrome

M. D. Lloyd, R. Wanders, D. M. van den Brink, 2007, Journal of enzyme inhibition and medicinal chemistry.

S-(N-Methylcarbamoyl)-N-acetylcysteine: a urinary metabolite of the hepatotoxic experimental antitumour agent N-methylformamide (NSC 3051) in mouse, rat and man.

A. Gescher, M. Threadgill, P. Kestell, 1986, Biochemical pharmacology.

The formation and metabolism of N-hydroxymethyl compounds--III. The metabolic conversion of N-methyl and N,N,-dimethylbenzamides to N-hydroxymethyl compounds.

J. Hickman, D. Ross, A. Gescher, 1983, Biochemical pharmacology.

Modulation of luminol-dependent chemiluminescence of murine macrophages by flavone and its synthetic derivatives.

W. Krol, M. Threadgill, Z. Czuba, 1995, Arzneimittel-Forschung.

α-Methylacyl-CoA racemase (AMACR): metabolic enzyme, drug metabolizer and cancer marker P504S.

M. D. Lloyd, Timothy J. Woodman, P. Wood, 2013, Progress in lipid research.

A biodegradable multiblock co-polymer derived from an alpha, omega-bis(methylamino)peptide and an alpha, omega-bis(oxiranylmethyl)poly(ethylene glycol).

C. Pouton, M. Threadgill, S. E. Matthews1, 2000, Journal of Controlled Release.

Hydrolysis of ibuprofenoyl-CoA and other 2-APA-CoA esters by human acyl-CoA thioesterases-1 and -2 and their possible role in the chiral inversion of profens.

M. D. Lloyd, Timothy J. Woodman, M. Threadgill, 2013, Biochemical pharmacology.

Chiral inversion of NSAID-CoA esters by human ∝-methylacyl-CoA racemase

M. D. Lloyd, P. Wood, M. Threadgill, 2011 .

Chiral inversion of 2-arylpropionyl-CoA esters by human α-methylacyl-CoA racemase 1A (P504S)--a potential mechanism for the anti-cancer effects of ibuprofen.

M. D. Lloyd, Timothy J. Woodman, P. Wood, 2011, Chemical communications.

Studies of the pharmacology of N-methylformamide in mice.

D. Ross, A. Gescher, M. Threadgill, 1982, Cancer treatment reports.

Activities of serine hydroxymethyltransferase in murine tissues and tumours.

M. Tisdale, M. Threadgill, S. Tendler, 1987, Cancer letters.

Unexpected formation of a 5-trifluoromethyloxazole from a 1,2-dibenzamidoalkene

M. Threadgill, S. Branch, D. E. Wilman, 1995 .

The metabolism of a stable N-hydroxymethyl derivative of a N-methylamide.

J. Hickman, D. Ross, A. Gescher, 1983, Life sciences.

The formation and metabolism of N-hydroxymethyl compounds--I. The oxidative N-demethylation of N-dimethyl derivatives of arylamines, aryltriazenes, arylformamidines and arylureas including the herbicide monuron.

J. Hickman, D. Ross, A. Gescher, 1983, Biochemical pharmacology.

The role of oxidative processes in the cytotoxicity of substituted 1,4-naphthoquinones in isolated hepatocytes.

S. Orrenius, D. Ross, M. Sandy, 1986, Archives of biochemistry and biophysics.

Novel 2-arylthiopropanoyl-CoA inhibitors of α-methylacyl-CoA racemase 1A (AMACR; P504S) as potential anti-prostate cancer agents.

M. D. Lloyd, Timothy J. Woodman, M. Threadgill, 2019, Bioorganic chemistry.

syn-Selectivity in the epoxidation of 1-(cyclohex-2-enyl)-2-nitroimidazole mediated by hydrogen bonding

P. Webb, M. Threadgill, 1991 .

syn-Selectivity in the Epoxidation of 1-(Cyclohex-2-enyl)-2- nitroimidazole Mediated by Hydrogen Bonding.

P. Webb, M. Threadgill, 1991 .

Synthesis and use of isotope-labelled substrates for a mechanistic study on human alpha-methylacyl-CoA racemase 1A (AMACR; P504S).

M. D. Lloyd, Timothy J. Woodman, M. Threadgill, 2009, Organic & biomolecular chemistry.

The metabolism of triazene antitumor drugs.

A. Gescher, M. Threadgill, 1987, Pharmacology & therapeutics.

Structure-activity relationships of 2-arylquinazolin-4-ones as highly selective and potent inhibitors of the tankyrases.

M. D. Lloyd, M. Threadgill, P. Hayward, 2016, European journal of medicinal chemistry.

The perils of rational design--unexpected irreversible elimination of fluoride from 3-fluoro-2-methylacyl-CoA esters catalysed by α-methylacyl-CoA racemase (AMACR; P504S).

M. D. Lloyd, M. Threadgill, T. Woodman, 2014, Chemical communications.

Unexpected stereoselective exchange of straight-chain fatty acyl-CoA alpha-protons by human alpha-methylacyl-CoA racemase 1A (P504S).

M. D. Lloyd, M. Threadgill, T. Woodman, 2010, Chemical communications.

α‐Methylacyl‐CoA racemase – an ‘obscure’ metabolic enzyme takes centre stage

M. D. Lloyd, A. Wierzbicki, M. Threadgill, 2008, The FEBS journal.

Investigation of the mechanistic basis of N,N-dimethylformamide toxicity. Metabolism of N,N-dimethylformamide and its deuterated isotopomers by cytochrome P450 2E1.

A. Gescher, M. Threadgill, K. Thummel, 1993, Chemical research in toxicology.

Identification by proton NMR of N-(hydroxymethyl)-N-methylformamide as the major urinary metabolite of N,N-dimethylformamide in mice.

A. Gescher, M. Threadgill, P. Kestell, 1986, Life sciences.

Metabolism of the anticancer agent 1-(4-acetylphenyl)-3,3-dimethyltriazene.

E. Benfenati, M. D’Incalci, A. Gescher, 1983, Biomedical mass spectrometry.

Selective reactions in the triazene series. Part 2. Protodediazoniation of arenediazonium salts with formamide

M. Threadgill, A. Gledhill, 1986 .

Macromolecular Systems for Chemotherapy and Magnetic Resonance Imaging.

C. Pouton, S. E. Matthews, M. Threadgill, 1996 .

Reaction of Hetarylhydrazines with 1,1,1‐Trifluoropentane‐2,4‐dione and Ethyl 2,4‐Dioxovalerate.

M. Threadgill, Shiv P. Singh, Devinder Kumar, 1992 .

Synthesis of peptides containing S-(N-alkylcarbamoyl)cysteine residues, metabolites of N-alkylformamides in rodents and in humans

M. Threadgill, A. Gledhill, 1989 .

A study on the chiral inversion of mandelic acid in humans.

M. D. Lloyd, Timothy J. Woodman, M. Threadgill, 2014, Organic & biomolecular chemistry.

The generation of potentially toxic, reactive iminium ions from the oxidative metabolism of xenobiotic N-alkyl compounds.

J. Hickman, A. Gescher, M. Threadgill, 1985, Biochemical pharmacology.

Substituted flavones as aryl hydrocarbon (Ah) receptor agonists and antagonists.

S. Safe, M. Threadgill, M. Santostefano, 1996, Biochemical pharmacology.

Unusual deuterium isotope effect on the retention of formamides in gas—liquid chromatography

Jaroslav Mráz, Parmjit Jheeta, Andreas Gescher, 1993 .

Effects of steric bulk and stereochemistry on the rates of diketopiperazine formation from N -aminoacyl-2,2-dimethylthiazolidine-4-carboxamides (Dmt dipeptide amides) - a model for a new prodrug linker system

M. Threadgill, T. Arafat, G. Suaifan, 2006 .

A new synthesis of "push-pull" naphthalenes by condensation of nitro-2-methylbenzoate esters with dimethylacetamide dimethyl acetal

James A. Wright, M. Threadgill, A. Thompson, 2002 .

Labelled compounds of interest as antitumour agents-v1. Syntheses of [18O]-5-methylisoquinolinone and 1-(furan-2-yl-[18O]-methoxy)-5-methylisoquinoline

M. Threadgill, J. Berry, 1996 .

Synthesis of 4-alkyl-, 4-aryl- and 4-arylamino-5-aminoisoquinolin-1-ones and identification of a new PARP-2 selective inhibitor.

M. D. Lloyd, M. Threadgill, M. Mahon, 2011, Organic & biomolecular chemistry.

Formation of 3-aryl-5-nitroisocoumarins from 5-nitroisocoumarins and aromatic acyl chlorides under Friedel-Crafts conditions.

M. Threadgill, A. Thompson, Peter T. Sunderland, 2007, The Journal of organic chemistry.

Synthesis and Solid-state Conformations of 6S,8aR/S-6-Alkyl-3,3- dimethyltetrahydrooxazolo[3,4-a]pyrazine-5,8-diones (Pseudo proline Diketopiperazines)

P. Wood, M. Threadgill, M. Mahon, 2018 .

Formation of 3‐Aryl‐5‐nitroisocoumarins from 5‐Nitroisocoumarins and Aromatic Acyl Chlorides under Friedel—Crafts Conditions.

M. Threadgill, A. Thompson, Peter T. Sunderland, 2008 .

Synthesis of N-(Methoxycarbonylthienylmethyl)thioureas and Evaluation of Their Interaction with Inducible and Neuronal Nitric Oxide Synthase

M. Threadgill, G. Suaifan, C. Goodyer, 2010, Molecules.

Cloning, purification, crystallization and preliminary crystallographic analysis of the human histone deacetylase sirtuin 1.

M. D. Lloyd, K. Acharya, M. Threadgill, 2011, Acta crystallographica. Section F, Structural biology and crystallization communications.

S-2-amino-5-(2-nitroimidazol-1-yl)pentanoic acid: a model for potential bioreductively activated prodrugs for inhibitors of nitric oxide synthase (NOS) activity.

E. Chinje, I. Stratford, M. Threadgill, 1997, Anti-Cancer Drug Design.

Synthesis of 2-(4-carboxybutenyl)- and 2-(4-carboxybutynyl)-cyclopentene-1-carboxamides

M. D. Lloyd, M. Threadgill, Anne Beauchard, 2009 .

2.1 – N,N-Dimethylacetamide

A. Gescher, M. Threadgill, 1990 .

Observation by NMR of cationic Wheland-like intermediates in the deiodination of protected 1-iodonaphthalene-2,4-diamines in acidic media.

M. Threadgill, T. Woodman, E. A. Twum, 2013, Organic & biomolecular chemistry.

Highly Potent and Isoform Selective Dual Site Binding Tankyrase/Wnt Signaling Inhibitors That Increase Cellular Glucose Uptake and Have Antiproliferative Activity.

M. D. Lloyd, T. Pihlajaniemi, D. Tosh, 2017, Journal of medicinal chemistry.

Challenges associated with the synthesis of unusual o-carboxamido stilbenes by the Heck protocol: Intriguing substituent effects, their toxicological and chemopreventive implications.

S. Ng,, K. M. Chan, P. Wood, 2010, Organic & biomolecular chemistry.

2-Nitroimidazole dual-function bioreductive drugs: studies on the effects of regioisomerism and side-chain structural modifications on differential cytotoxicity and radiosensitization by aziridinyl and oxiranyl derivatives.

P. Webb, G. Adams, I. Stratford, 1992, Journal of medicinal chemistry.

Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro.

M. D. Lloyd, P. Wood, M. Threadgill, 2015, Bioorganic & medicinal chemistry.

Effect of Poly (ADP-ribose) Polymerase-1 Inhibition on the Proliferation of Murine Colon Carcinoma CT26 Cells

M. Threadgill, L. Cai, Yalan Wang, 2009, Pathology & Oncology Research.

Reductive cyclisation of 2-cyanomethyl-3-nitrobenzoates

M. Threadgill, E. Woon, Peter T. Sunderland, 2006 .

Selective Reductions of 1-(Carbonyl)Substituted 2-Nitro-Imidazoles with Alkali Metal Borohydrides and with Borane. Tetrahydrofuran

P. Webb, M. Threadgill, 1990 .

Unexpected stereoselective exchange of straight-chain fatty acyl-CoA alpha-protons by human alpha-methylacyl-CoA racemase 1A (P504S).

M. D. Lloyd, Timothy J. Woodman, M. Threadgill, 2010, Chemical Communications.

The perils of rational design--unexpected irreversible elimination of fluoride from 3-fluoro-2-methylacyl-CoA esters catalysed by α-methylacyl-CoA racemase (AMACR; P504S).

M. D. Lloyd, Timothy J. Woodman, M. Threadgill, 2014, Chemical communications.